BOSWELLIC ACID (BOSWELLIA CARTERI)
January 24, 2020BMI-1
January 24, 2020- … -apoptotic activity of whole extract and isolated indicaxanthin from Opuntia ficus-indica associated with re-activation of the onco-suppressor p16INK4a gene in human
- … -associated heterochromatin foci are dispensable for cellular senescence, occur in a cell type-and insult-dependent manner and follow expression of p16INK4a
- … -mediated overexpression of p15INK4B inhibits human glioma cell growth, induces replicative senescence, and inhibits telomerase activity similarly to p16INK4a.
- … and immunoexpression of p16INK4a tumor suppressor gene in primary breast cancer tissue and their quantitative p16INK4a hypermethylation in plasma by …
- … cancer metastases to sentinel nodes: evaluation of its role as a marker for the presence of metastases in non-sentinel axillary nodes, and comparison to p16INK4a
- … E2F-1 blocks terminal differentiation and loss of leukemogenicity of M1 myeloblastic leukemia cells without abrogating induction of p15INK4B and p16INK4a
- … Effects of human insulin-like growth factor I gene modified myoblast transplantation on cardiomyocyte insulin-like growth factor I, p16INK4a and proliferating cell …
- … Increases the Cell Cycle Progression of Human Gingival Fibroblasts by Increasing Cyclin E and CDK 2 Expression and Decreasing p21WAF1/CIP1 and p16INK4a …
- … kinase inhibitor p19INK4d: comparison to known ankyrin-repeat-containing structures and implications for the dysfunction of tumor suppressor p16INK4a
- … natural history of human papillomavirus infection in the head and neck squamous epithelium with particular respect to the significance of p16INK4a expression as a …
- … neurons of the embryonic and postnatal rat brain: Comparison with expression of the cell cycle regulators p21Waf1/Cip1, p27Kip1, p57Kip2, p16INK4a, cyclin G1, and …
- … of a novel human B‐cell line (OZ) with t (14; 18)(q32; q21) and aberrant p53 expression was associated with the homozygous deletions of p15INK4B and p16INK4a …
- … of human papillomavirus in a Spanish cohort of penile squamous cell carcinomas: Correlation with pathologic subtypes, p16INK4a expression, and prognosis
- … of limited adequacy and insufficient for grading as low or high grade: outcome, clinico-pathological correlates, and predictive role of p16INK4a and Ki67 biomarker …
- … of oncogenic KRAS mutations in squamous cell carcinomas of the anogenital tract and head and neck region independent of human papillomavirus and p16INK4a …
- … of penile carcinogenesis: HPV-induced penile cancers overexpress p16INK4a, HPV-negative cancers associated with dermatoses express p53, but lack p16INK4a …
- … of Penile Carcinogenesis: HPV-Induced Penile Cancers Overexpress p16INK4a, HPV-Negative Cancers Associated with Dermatoses Express p53, but Lack p16INK4a …
- … of the telomerase catalytic subunit, hTERT, induces resistance to transforming growth factor beta growth inhibition in p16INK4a (-) human mammary epithelial cells …
- … of the telomerase catalytic subunit, hTERT, induces resistance to transforming growth factor β growth inhibition in p16INK4a (−) human mammary epithelial cells
- … plus thioacetamide in Fischer 344 rats: Induction of gankyrin expression in liver fibrosis, pRB degradation in cirrhosis, and methylation of p16INK4a exon 1 in …
- … regulated by hepatocyte growth factor via ERK-dependent and ERK-independent signaling pathways, leading to increased expression of p16INK4a in hepatoma cells
- … S-transferase P1 and NADPH quinone oxidoreductase polymorphisms are associated with aberrant promoter methylation of p16INK4a and O6-methylguanine-DNA …
- … Senescence of Endothelial Progenitor Cells and Promotes Endothelial Repair by Suppressing the p38 MAP Kinase/p16INK4a Signaling Pathway. Diabetes 2010; 59 …
- … Senescence of Endothelial Progenitor Cells and Promotes Endothelial Repair by Suppressing the p38 MAP Kinase/p16INK4a Signaling Pathway. Diabetes 2010; 59 …
- … shows highly variable prevalence in esophageal squamous cell carcinoma and no significant correlation to p16INK4a overexpression: a systematic review
- … the mitogen-activated protein kinase pathway promotes DNA synthesis in primary hepatocytes from p21Cip-1/WAF1-null mice, but not in hepatocytes from p16INK4a …
- … Therapy in Ovarian Cancer: See The Biology Behind: ME Murphy, The Battle between Tumor Suppressors: Is Gene Therapy Using p16INK4a More Efficacious Than …
- … to several cancers but absence of linkage between dysplastic nevus syndrome and CDKN2A in a melanoma family with a mutation in the CDKN2A (p16INK4a) …
- … virus in oral squamous cell carcinoma and premalignat lesions, and the genetic and epigenetic aberrations of p14ARF and p16INK4a tumour suppressor genes …
- 1003 ORAL Crosstalk Between Homeobox Proteins and Polycomb Complexes in p16INK4a Regulation
- 1367 p16INK4a: No Correlation with Transcriptionally Active HPV16/18 or Outcomes in Oral Cavity Carcinoma
- 188 Point-of-care surrogate biomarkers for cervical cancer screening: feasibility of E7 oncoprotein and p16INK4a detection in cervical samples
- 5-Aza-2′-deoxycitydine induces demethylation and up-regulates transcription of p16INK4a gene in human gastric cancer cell lines.
- 5-Aza-2′-deoxycytidine leads to down-regulation of aberrant p16INK4a RNA transcripts and restores the functional retinoblastoma protein pathway in hepatocellular …
- 5-Aza-2′-deoxycytidine protects against emphysema in mice via suppressing p16INK4a expression in lung tissue
- 5‐Fluorouracil or gemcitabine combined with adenoviral‐mediated reintroduction of p16INK4a greatly enhanced cytotoxicity in Panc‐1 pancreatic adenocarcinoma …
- 9 Role of the p14ARF and p16INK4a Genes in Prostate Cancer
- A CDKN2A mutation in familial melanoma that abrogates binding of p16INK4a to CDK4 but not CDK6
- A cis-element within the ARF locus mediates repression of p16INK4a expression via long-range chromatin interactions
- A cocktail of p16INK4a and Ki-67, p16INK4a and minichromosome maintenance protein 2 as triage tests for human papillomavirus primary cervical cancer …
- A common variant of the p16INK4a genetic region is associated with physical function in older people
- A comparison analysis of anti-tumor efficacy of adenoviral gene replacement therapy (p14ARF and p16INK4a) in human mesothelioma cells.
- A comparison of the clinical utility of p16INK4a immunolocalization with the presence of human papillomavirus by hybrid capture 2 for the detection of cervical …
- A comprehensive evaluation of human papillomavirus positive status and p16INK4a overexpression as a prognostic biomarker in head and neck squamous …
- A Cyclin-Dependent Kinase Inhibitor, p16INK4a, in The Human Cancer Cells
- A High Prevalence of Functional Inactivation by Methylation Modification of p16INK4a/CDKN2/MTS1 Gene in Primary Urothelial Cancers
- A keratinocyte hypermotility/growth-arrest response involving laminin 5 and p16INK4a activated in wound healing and senescence
- A limited role for p16INK4a and p19Arf in the loss of hematopoietic stem cells during proliferative stress
- A microarray to analyze methylation patterns of p16INK4a gene 5′-CpG islands
- A new system for regulated functional gene expression for gene therapy applications: Nuclear delivery of a p16INK4a-estrogen receptor carboxy terminal fusion …
- A new system for regulated functional gene expression for gene therapy applications: nuclear delivery of a p16INK4a-estrogen receptor carboxy terminal fusion …
- A novel and sensitive electrogenerated chemiluminescence biosensor for detection of p16INK4a gene based on the functional paste-like nanofibers composites …
- A Novel Function for the Tumor Suppressor p16INK4a Induction of Anoikis via Upregulation of the α5β1 Fibronectin Receptor
- A novel p16INK4a mutation associated with esophageal squamous cell carcinoma in a high risk population
- A novel p16INK4a transcript
- A novel suicide gene therapy for the treatment of p16INK4a-overexpressing tumors
- A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma
- A panel of p16INK4a, MIB1 and p53 proteins can distinguish between the 2 pathways leading to vulvar squamous cell carcinoma
- A Pathway-focused GSEA Platform In AML That Interrogates Interaction of Flt3ITD and tMLL with Their Epigenetic Targets (p16INK4a, DAPK1, and RUNX3), While …
- A phase 1/2a study to test the safety and immunogenicity of a p16INK4a peptide vaccine in patients with advanced human papillomavirus‐associated cancers
- A piezoelectric immunosensor for the rapid detection of p16INK4a expression in liquid-based cervical cytology specimens
- A Prospective Study of Human Papillomavirus Changes Detected by Ki-67 and p16INK4a Immunohistochemistry in Women treated With Radiation for Cervical Cancer …
- A quantitative model for age-dependent expression of the p16INK4a tumor suppressor
- A search for CDKN2A/p16INK4a mutations in melanocytic nevi from patients with melanoma and spouse controls by use of laser-captured microdissection
- A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy
- A simple stochastic model for the feedback circuit between p16INK4a and p53 mediated by p38MAPK: implications for senescence and apoptosis
- A Study on Significance of p16INK4a and Ki67 Proteins in Cervical Biopsies
- A subset of head and neck squamous cell carcinomas exhibits integration of HPV 16/18 DNA and overexpression of p16INK4a and p53 in the absence of mutations …
- A two-stage, p16INK4a-and p53-dependent keratinocyte senescence mechanism that limits replicative potential independent of telomere status
- ABCB5 and the regulation of p16INK4a by non-coding RNA
- Aberrant CpG island methylation of the p16INK4a and estrogen receptor genes in rat lung tumors induced by particulate carcinogens
- Aberrant expression of nNOS in pyramidal neurons in Alzheimer’s disease is highly co-localized with p21ras and p16INK4a
- Aberrant expression of p16INK4a in human cancers–a new biomarker?
- Aberrant expression of p53, p16INK4a and Ki‐67 as basic biomarker for malignant progression of oral leukoplakias
- Aberrant expression of pRb and p16INK4a, alone or in combination, indicates poor outcome after resection in patients with colorectal carcinoma
- Aberrant methylation of hMLH1 and p16INK4a in Tunisian patients with sporadic colorectal adenocarcinoma
- Aberrant methylation of p14ARF, p15INK4b and p16INK4a genes and location of the primary site in pulmonary squamous cell carcinoma
- Aberrant methylation of p16INK4a and deletion of p15INK4b are frequent events in human esophageal cancer in Linxian, China
- Aberrant methylation of p16INK4a in anatomic and gender-specific subtypes of sporadic colorectal cancer
- Aberrant methylation of p16INK4a is an early event in lung cancer and a potential biomarker for early diagnosis
- Aberrant methylation of the CDKN2a/p16INK4a gene promoter region in preinvasive bronchial lesions: A prospective study in high‐risk patients without invasive …
- Aberrant p16INK4a and DPC4/Smad4 expression in intraductal papillary mucinous tumours of the pancreas is associated with invasive ductal adenocarcinoma
- Aberrant p16INK4a methylation: Relation to viral related chronic liver disease and hepatocellular carcinoma
- Aberrant p16INK4a RNA transcripts expressed in hepatocellular carcinoma cell lines regulate pRb phosphorylation by binding with CDK4, resulting in delayed cell …
- Aberrant promoter methylation of p16INK4a and O6-methylguanine-DNA methyltransferase genes in workers at a Chinese uranium mine
- Aberrant promoter methylation of p16INK4a, RARB2 and SEMA3B in bronchial aspirates from patients with suspected lung cancer
- Aberrante Methylierung des p16INK4a-Promotors als Tumormarker für die molekularzytologische Diagnostik des Lungenkarzinoms an Bronchialaspiraten
- Aberrations of p16INK4a, p14ARF and p15INK4B genes in pediatric solid tumors
- Aberrations of the p14ARF and p16INK4a Genes in Renal Cell Carcinomas
- ABL oncogene amplification with p16INK4a gene deletion in precursor T‐cell acute lymphoblastic leukemia/lymphoma: Report of the first case
- Abnormal Expression of p16INK4a, Cyclin D1, Cyclin‐Dependent Kinase 4 and Retinoblastoma Protein in Gastric Carcinomas
- Abolition of cyclin-dependent kinase inhibitor p16INK4a and p21Cip1/Waf1 functions permits Ras-induced anchorage-independent growth in telomerase-immortalized …
- Absence of p16INK4a and truncation of ARF tumor suppressors in chickens
- Abstract A12: Vicoryx: A phase I/IIa clinical trial using a p16INK4a derived peptide as vaccine in patients with advanced human papillomavirus-associated cancer
- Abstract A136: p16INK4a status of primary tumor modulates local immune response in vulvar squamous cell carcinoma
- Abstract B018: Restoration of p16INK4a expression in circulating tumor cells in patients with advanced solid tumors treated with deoxycytidine analogs and …
- Abstract LB-273: The tumor suppressor p16INK4a regulates extensive plasticity in rare somatic cells found in adult human tissue.
- Abstract P4-04-26: Down-regulation of p16INK4a inhibits miR-146b-5p and modulates IL-6 in breast stromal fibroblasts
- Abstract P6-08-34: p16INK4a expression and chemotherapy toxicity in women with early stage breast cancer
- Abstract# 4918: Loss of p16INK4a/ARF leads to up-regulation of IGFBP2 in human glioma and promotes formation of high-grade glioma in a mouse model
- Abstract# 5151: High frequency of ASC/TMS1, Rassf1A, and p16INK4a promoter methylation in succinate dehydrogenase complex B pheochromocytomas
- Abstract# 5340: The tumor suppressor p16INK4a protein positively regulates cyclin D1, E2F1 and p21WAF1 through negative control of AUF1
- Accelerated expression of senescence associated cell cycle inhibitor p16INK4a in kidneys with glomerular disease
- Accelerated somatic cell senescence and changes in p16INK4a expression after exogenous DNA transfection
- Acquired hypermethylation of the p16INK4a promoter in abdominal paraganglioma: relation to adverse tumor phenotype and predisposing mutation
- Acquisition of p16INK4a and p15INK4b gene abnormalities between initial diagnosis and relapse in children with acute lymphoblastic leukemia.
- Acquisition of p16INK4aandp15INK4BGene Abnormalities Between Initial Diagnosis and Relapse in Children With Acute Lymphoblastic Leukemia
- Activation of RB tumor suppressor protein and growth suppression of small cell lung carcinoma cells by reintroduction of p16INK4a gene.
- Active transcriptional repression by the Rb–E2F complex mediates G1 arrest triggered by p16INK4a, TGFβ, and contact inhibition
- Acute myeloid leukemia induces protumoral p16INK4a-driven senescence in the bone marrow microenvironment
- Acute telomere deprotection prevents ongoing BFB cycles and rampant instability in p16INK4a-deficient epithelial cells
- Adiponectin prevents diabetic premature senescence of endothelial progenitor cells and promotes endothelial repair by suppressing the p38 MAP kinase/p16INK4a …
- Adjunct p16INK4a Immunohistochemistry Aids the Detection of High-Grade Squamous Intraepithelial Lesions in Endocervical Curettage Specimens
- Age-related accumulation of oxidative DNA damage and alterations in levels of p16INK4a/CDKN2a, p21WAF1/CIP1/SDI1 and p27KIP1 in human CD4+ T cell clones …
- Ageing as developmental decay: insights from p16INK4a
- Aging and cancer resistance in lymphoid progenitors are linked processes conferred by p16INK4a and Arf
- Aging increases p16INK4a expression in vascular smooth-muscle cells
- All‑trans retinoic acid enhances the effect of 5‑aza‑2’‑deoxycytidine on p16INK4a demethylation, and the two drugs synergistically activate retinoic acid …
- Allele-specific locus binding and genome editing by CRISPR at the p16INK4a locus
- Alterations in the p16INK4a/CDKN2A Tumor Suppressor Gene in Gastrinomas
- Alterations in the p53 pathway and p16INK4a expression predict overall survival in metastatic melanoma patients treated with dacarbazine
- Alterations of CDKN2 (MTS1/p16INK4a) gene in paraffin-embedded tumor tissues of human stomach, lung, cervix and liver cancers
- Alterations of cyclin-dependent kinase 4 inhibitor (p16INK4a/MTS1) gene structure and expression in acute lymphoblastic leukemias.
- Alterations of expression of Rb, p16INK4a and cyclin D1 in non‐small cell lung carcinoma and their clinical significance
- Alterations of p14ARF and p16INK4a genes in salivary gland carcinomas
- Alterations of p16INK4a and p14ARF in patients with severe oral epithelial dysplasia
- Alterations of p16INK4a and p15INK4B genes in gastric carcinomas
- Alterations of p16INK4a and p18INK4C, Human Papillomavirus infections and Expression of the Cell Cycle Associated Proteins in Cervical Carcinomas.
- Alterations of p16INK4a Gene in Korean Squamous Cell Carcinoma and Basal Cell carcinoma of the Skin
- Alterations of p16INK4a tumour suppressor gene in mucoepidermoid carcinoma of the salivary glands
- Alterations of pRb1-cyclin D1-cdk4/6-p16INK4a pathway in endometrial carcinogenesis
- Alterations of Rb, p16INK4a and cyclin D1 in the tumorigenesis of oral squamous cell carcinomas
- Alterations of the cell-cycle inhibitors p27KIP1 and p16INK4a are frequent in blastic plasmacytoid dendritic cell neoplasms
- Alterations of the p16INK4a gene in human ovarian cancers
- Alterations of the p16INK4a gene in resected nonsmall cell lung tumors and exfoliated cells within sputum
- Alterations of the p16INK4a/p14ARF pathway in clear cell sarcoma
- Alterations of the p16INK4a/Rb/cyclin-D1 pathway in vulvar carcinoma, vulvar intraepithelial neoplasia, and lichen sclerosus
- Alterations of the tumor suppressor genes CDKN2A (p16INK4a), p14ARF, CDKN2B (p15INK4b), and CDKN2C (p18INK4c) in atypical and anaplastic meningiomas
- Altered p16INK4a and Fhit expression in carcinogenesis and progression of human oral cancer
- AML at older age: age-related gene expression profiles reveal a paradoxical down-regulation of p16INK4a mRNA with prognostic significance
- An analysis on the combination expression of HPV L1 capsid protein and p16INK4a in cervical lesions
- An antibody to p16INK4a recognizes a modified form of galectin-3
- An association between nuclear morphology and immunohistochemical expression of p53 and p16INK4a in lung cancer cells
- An association of DNMT3b protein expression with p16INK4a promoter hypermethylation in non-smoking female lung cancer with human papillomavirus infection
- An evaluation of p16INK4a expression in cervical intraepithelial neoplasia specimens, including women with HIV-1
- An evaluation of the diagnostic and prognostic significance of p16INK4a/p21WAF1/Cip1 immunostaining in squamous intraepithelial lesions of the uterine cervix …
- An immunohistochemical study of p16INK4a expression in multistep thyroid tumourigenesis
- An internal ribosomal entry site in the 5′-untranslated region of p16INK4a mRNA provides a novel mechanism for the regulation of its translation
- An upward trend in DNA p16INK4a methylation pattern and high risk HPV infection according to the severity of the cervical lesion
- Anal intraepithelial neoplasia: correlation of grade with p16INK4a immunohistochemistry and HPV in situ hybridization
- Analysis of antibodies to p16INK4a tumor suppressor gene products in lung cancer patients.
- Analysis of cell cycle regulators: p16INK4a, pRb, and CDK4 in low-and high-grade meningiomas
- Analysis of cyclin dependent kinase inhibitors, p16INK4a and p15INK4b gene, in acute lymphoblastic leukemias
- Analysis of Immunohistochemical Expression of p16INK4a in Preneoplastic and Neoplastic Squamous cell lesions of Cervix
- Analysis of p16INK4a expression of oral squamous cell carcinomas in Taiwan: Prognostic correlation without relevance to betel quid consumption
- Analysis of p16INK4a gene promoter in male germ-cell tumors: identification of a new point mutation
- Analysis of P53, p16INK4a, PRB and cyclin D1 expression and human papillomavirus in primary ovarian serous carcinoma
- Analysis of p53/BAX/p16INK4a/CDKN2 in Esophageal Squamous Cell Carcinoma: High BAX and p16INK4a/CDKN2 Identifies Patients With Good Prognosis
- Analysis of pRb, p16INK4a proteins and proliferating antigens, PCNA, Ki-67 and MCM5 expression in aggressive fibromatosis (desmoid tumor)
- Analysis of the p16INK4a, p15INK4B and p18INK4C genes in multiple myeloma
- Antibody anti-p16INK4a in cervical cytology
- Antioxidants cinnamaldehyde and Galactomyces fermentation filtrate downregulate senescence marker CDKN2A/p16INK4a via NRF2 activation in keratinocytes
- Application of a time-resolved fluoroimmunoassay for detection of p16INK4a in cervix
- Are adjunctive markers useful in routine cervical cancer screening? Application of p16INK4a and HPV‐PCR on ThinPrep samples with histological follow‐up
- Assessing the use of p16INK4a promoter gene methylation in serum for detection of bladder cancer
- Assessment of Correlation Between p16INK4a Staining, Specific Subtype of Human Papillomavirus, and Progression of LSIL/CIN1 Lesions: First Comparative Study
- Assessment of the association between the frequency of micronucleus and p16INK4a/Ki-67 co-expression in patients with cervical intraepithelial lesions
- Association between folate metabolism-related gene polymorphisms and methylation of p16INK4a and hMLH1 genes in spontaneously aborted embryos with normal …
- Association between p16INK4a promoter methylation and HNSCC: a meta-analysis of 21 published studies
- Association between p16INK4a promoter methylation and non-small cell lung cancer: a meta-analysis
- Association between p16INK4a promoter methylation and ovarian cancer: a meta-analysis of 12 published studies
- Association of CDKN2A (p16INK4a) Polymorphisms and Promoter Methylation with Head and Neck Squamous Cell Carcinoma (HNSCC) in Puerto Rican Patients
- Association of CDKN2A/p16INK4a with human head and neck keratinocyte replicative senescence: relationship of dysfunction to immortality and neoplasia.
- Association of low p16INK4a and p15INK4b mRNAs expression with their CpG islands methylation with human hepatocellular carcinogenesis
- Association of p16INK4a hypermethylation with hepatitis B virus X protein expression in the early stage of HBV‐associated hepatocarcinogenesis
- Association of p16INK4a overexpression with improved outcomes in young patients with squamous cell cancers of the oral tongue
- Association of the expression of p53 and p16INK4a with the clinical and morphological characteristicsof patients with head and neck squamous cell cancer
- Associations of p16INK4a promoter hypermethylation with squamous intra-epithelial lesion, cervical cancer and their clinicopathological features: a meta …
- Atypical leiomyomas of the uterus with long-term follow-up after myomectomy with immunohistochemical analysis for p16INK4a, p53, Ki-67, estrogen receptors, and …
- Autophagy regulates the localization and degradation of p16INK4a
- Avaliação da expressão imunoistoquímica da proteína p16INK4a no adenocarcinoma de esôfago
- Azacitidine induces demethylation of p16INK4a and inhibits growth in adult T-cell leukemia/lymphoma
- Based immunosensor with signal amplification by enzyme-labeled anti-p16INK4a multifunctionalized gold nanoparticles for cervical cancer screening
- BAX and p16INK4a are independent positive prognostic markers for advanced tumour stage of nonsmall cell lung cancer
- Biallelic mutations in p16INK4a confer resistance to Ras-and Ets-induced senescence in human diploid fibroblasts
- Biologic and Biochemical Analyses of p16INK4a Mutations From Primary Tumors
- Biomarkers for cervical cancer screening: the role of p16INK4a to highlight transforming HPV infections
- Biomarkers in cervical screening: quantitative reverse transcriptase PCR analysis of p16INK4a expression
- Bmi-1 extends the replicative life span of normal human oral keratinocytes independently of p16INK4a
- Bmi-1 promotes neural stem cell self-renewal and neural development but not mouse growth and survival by repressing the p16INK4a and p19Arf senescence …
- Bmi1 Loss in the Organ of Corti Results in p16INK4a Upregulation and Reduced Cell Proliferation of Otic Progenitors In Vitro
- Bmi1 promotes prostate tumorigenesis via inhibiting p16INK4a and p14ARF expression
- Bone marrow p16INK4a-deficiency does not modulate obesity, glucose homeostasis or atherosclerosis development
- Both p16INK4a and the p19Arf-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse
- Bowen’s disease on the sole: p16INK4a overexpression associated with human papillomavirus type 16
- c-JUN prevents methylation of p16INK4a (and Cdk6): the villain turned bodyguard
- C-terminal binding protein-2 promotes cell proliferation and migration in breast cancer via suppression of p16INK4a
- C‐terminal domain of p16INK4a is adequate in inducing cell cycle arrest, growth inhibition and CDK4/6 interaction similar to the full length protein in HT‐1080 …
- C282Y HFE polymorphism imparts temozolomide and 17-DMAG resistance via p16INK4a
- Cancer-associated mutations at the INK4a locus cancel cell cycle arrest by p16INK4a but not by the alternative reading frame protein p19ARF
- Candidate tumor-suppressor genes MTS1 (p16INK4a) and MTS2 (p15INK4B) display frequent homozygous deletions in primary cells from T-but not from B-cell …
- CD47 activation-induced UHRF1 over-expression is associated with silencing of tumor suppressor gene p16INK4a in glioblastoma cells
- Cdk2-dependent phosphorylation and functional inactivation of the pRB-related p130 protein in pRB (−), p16INK4a (+) tumor cells
- CDK4 and CDK6 delay senescence by kinase-dependent and p16INK4a-independent mechanisms
- CDK4/6 and IGF1 receptor inhibitors synergize to suppress the growth of p16INK4a-deficient pancreatic cancers
- CDK6 and p16INK4a in lymphoid malignancies
- CDKN2 (MTS1/p16INK4a) Gene Alterations in Adult T-Cell Leukemia/Lymphoma
- CDKN2 (MTS1/p16INK4a) Gene Alterations in Hematological Malignancies
- CDKN2A (p14ARF/p16INK4a) and ATM promoter methylation in patients with impalpable breast lesions
- CDKN2A (p16INK4a) and CDK4 mutation analysis in 131 Australian melanoma probands: Effect of family history and multiple primary melanomas
- CDKN2A (p16INK4a) somatic and germline mutations
- Cdkn2a encodes functional variation of p16INK4a but not p14ARF, which confers selection in mouse lung tumorigenesis
- Cdkn2a, the cyclin-dependent kinase inhibitor encoding p16INK4a and p19ARF, is a candidate for the plasmacytoma susceptibility locus, Pctr1
- CDKN2A/p16INK4a 5′ UTR variants in melanoma predisposition: Lost in translation, somewhere
- CDKN2A/p16INK4a expression is associated with vascular progeria in chronic kidney disease
- CDKN2a/p16INK4a mutations and lack of p19ARF involvement in familial melanoma kindreds
- Cdkn2a/p16INK4a regulates fasting-induced hepatic gluconeogenesis through the PKA-CREB-PGC1α pathway
- CDKN2A/p16INK4a variants association with breast cancer and their in-silico analysis
- Cell cycle arrest and cytochrome c-mediated apoptotic induction by MCS-5A is associated with up-regulation of p16INK4a in HL-60 cells
- Cell cycle regulators p16INK4a in metaplasia, dysplasia, and adenocarcinoma of Barrett’s esophagus.
- Cell protein p16INK4a hyperexpression in epithelial malignancies induced by human papillomaviruses
- Cells exhibiting strong p16INK4a promoter activation in vivo display features of senescence
- Cellular senescence in biliary pathology. Special emphasis on expression of a polycomb group protein EZH2 and a senescent marker p16INK4a in bile ductular …
- Cellular senescence markers p16INK4a and p21CIP1/WAF are predictors of Hodgkin lymphoma outcome
- Cellular senescence mediated by p16INK4a-coupled miRNA pathways
- Cellular senescence protein p16INK4a of cancer-associated fibroblasts (CAFs) as a prognostic indicator for cholangiocarcinoma patients
- Centrosome aberrations in human mammary epithelial cells driven by cooperative interactions between p16INK4a deficiency and telomere-dependent …
- Cervical biopsy: Is the histological diagnosis reliable and reproducible? Utility of p16INK4a in its achievement
- Changes in p16INK4a (p16) expression, a biomarker of aging, in peripheral blood T-cells (PBTC) in patients receiving anthracycline (A) vs non-anthracycline (NoA) …
- Characterization of coordinated immediate responses by p16INK4a and p53 pathways in UVB-irradiated human skin cells
- Characterization of regulatory elements on the promoter region of p16INK4a that contribute to overexpression of p16 in senescent fibroblasts
- Characterization of squamous cell cancers of the vulvar anterior fourchette by human papillomavirus, p16INK4a, and p53
- Chemiluminescent Quantitative Immunohistochemical p16INK4a Localization as a Marker for Cervical Intraepithelial Neoplasias
- Chemotherapy and stem cell transplantation increase p16INK4a expression, a biomarker of T-cell aging
- Chemotherapy and Stem Cell Transplantation Increase p16INK4a Expression, a Biomarker of T-cell Aging
- Chlamydia trachomatis and human papillomavirus coinfection: association with p16INK4a and Ki67 expression in biopsies of patients with pre-neoplastic and …
- Chronic hepatitis B virus infection and the methylation status of p16INK4a promoter
- Chronic Oral Exposure to Inorganic Arsenate Interferes with Methylation Status of p16INK4a and RASSF1A and Induces Lung Cancer in A/J Mice
- Chronic stress exposure and daily stress appraisals relate to biological aging marker p16INK4a
- CHRONIC STRESS EXPOSURE AND DAILY STRESS APPRAISALS RELATE TO BIOLOGICAL AGING MARKER p16INK4a IN MID-LIFE PARENTS
- Ciliated muconodular papillary tumor of the lung harboring BRAF V600E mutation and p16INK4a overexpression without proliferative activity may represent …
- Classical and non-classical HLA molecules and p16INK4a expression in precursors lesions and invasive cervical cancer
- Cleaved high molecular weight kininogen induces endothelial progenitor cell senescence in a ROS–p38MAPK-p16INK4a signaling pathway and inhibits their …
- Clinical role of hWAPL in histologic diagnosis of cervical cancer and cervical intraepithelial neoplasia: Correlation with p16INK4a expression and HPV testing
- Clinical Role of p16INK4a Expression in Liquid-Based Cervical Cytology: Correlation With HPV Testing and Histologic Diagnosis
- Clinical significance of p16INK4a and p14ARF promoter methylation in renal cell carcinoma: a meta-analysis
- Clinical Significance of p16INK4a and p53 Overexpression in Endocrine Tumors of the Gastrointestinal Tract
- Clinical significance of p16INK4a and retinoblastoma proteins in non-small-cell lung carcinoma
- Clinical significance of p53 and p16INK4a status in a contemporary North American Penile Carcinoma Cohort
- Clinicopathologic significance of p16INK4a, Ki-67 and HPV DNA16/18 expression in squamous cell lesions of postmenopausal women cervix.
- Clinicopathological comparison of adenocarcinoma of cervix and endometrium using cell cycle markers: p16INK4a, P21waf1, and p27Kip1 on 132 cancers
- Clinicopathological parameters of cervical cancer based on the expression of p16INK4a proteins
- Cloning and characterization of murine p16INK4a and p15INK4b genes.
- Co-expression of p16INK4a and laminin 5 by keratinocytes: a wound-healing response coupling hypermotility with growth arrest that goes awry during …
- Co-expression of p16INK4a and laminin 5 γ2 by microinvasive and superficial squamous cell carcinomas in vivo and by migrating wound and senescent keratinocytes …
- Co-regulation of p16INK4a and migratory genes in culture conditions that lead to premature senescence in human keratinocytes
- Coexpression of p16INK4a and laminin55 gamma 2 in keratinocytes: a normal wound-healing response that goes awry during neoplastic progression
- Coincidental alterations of p16INK4a/CDKN2 and other genes in human lung cancer cell lines.
- Collateral damage: Molecular aging and p16INK4a senescence protein in testicular cancer survivors treated with chemotherapy.
- Collective inhibition of pRB family proteins by phosphorylation in cells with p16INK4a loss or cyclin E overexpression
- Combination of p16INK4a‐Ki67 immunocytology and HPV polymerase chain reaction for the noninvasive analysis of HPV involvement in head and neck cancer
- Combination of p16INK4a/Ki67 immunocytology and hpv polymerase chain reaction for the noninvasive analysis of HPV involvement in head and neck cancer
- Combination radiation and adenovirus-mediated p16INK4a gene therapy in a murine model for head and neck cancer
- Combined analysis of HPV DNA and p16INK4a expression to predict prognosis in ASCUS and LSIL pap smears
- Combined detection of p16INK4a and IMP3 increase the concordance rate between cervical cytologic and histologic diagnosis
- Combined Expression of p16INK4a and p27Kip1, But Not p21WAF1, Differentiates Endocervical from Endometrial Adenocarcinoma
- Combined p16INK4a and human papillomavirus testing improves the prediction of cervical intraepithelial neoplasia (CIN II-III) in Thai patients with low-grade …
- Combined serial section‐based 3D reconstruction of cervical carcinoma invasion using H&E/p16INK4a/CD3 alternate staining
- Combining routine morphology, p16INK4a immunohistochemistry, and in situ hybridization for the detection of human papillomavirus infection in penile carcinomas: A …
- Comments on Bu et al.“p16INK4a overexpression and survival in osteosarcoma patients: a meta analysis”
- Comments on the article of Bu, et al entitled “p16INK4a overexpression and survival in osteosarcoma patients: a meta analysis”
- Comparative detection and quantitation of human CDK inhibitor mRNA expression of p15INK4B, p16INK4a, p16β, p18INK4C, p19INK4D, p21WAF1, p27KIP1 and …
- Comparison Between p16INK4a Immunohistochemistry and Human Papillomavirus Polymerase Chain Reaction Assay in Oral Papillary Squamous Cell Carcinoma
- Comparison of p16INK4a and Hybrid Capture® 2 human papillomavirus testing as adjunctive tests in liquid‐based gynecologic SurePath™ preparations
- Comparison of p16INK4a and ProEx™ C immunostaining on cervical ThinPrep® cytology and biopsy specimens
- Comparison of p16INK4a expression with p53 alterations in head and neck cancer by tissue microarray analysis
- Comparison of p16INK4a immunocytochemistry with the HPV polymerase chain reaction in predicting high grade cervical squamous intraepithelial lesions
- Comparison of p16INK4a immunostaining in benign and malignant HPV-related lesion
- Comparison of ProEx C with p16INK4a and Ki‐67 immunohistochemical staining of cell blocks prepared from residual liquid‐based cervicovaginal material: A pilot …
- Complex patterns of chromosome 9 alterations including the p16INK4a locus in Wilms tumours
- Comprehensive analysis of CDKN2A (p16INK4a/p14ARF) and CDKN2B genes in 53 melanoma index cases considered to be at heightened risk of melanoma
- Compromising the constitutive p16INK4a expression sensitizes human neuroblastoma cells to Hsp90 inhibition and promotes premature senescence
- Computational assessment of somatic and germline mutations of p16INK4a: Structural insights and implications in disease
- Concentrations of pro-inflammatory cytokines are not associated with senescence marker p16INK4a or predictive of intracellular emtricitabine/tenofovir …
- Concerted promoter hypermethylation of hMLH1, p16INK4a, and E‐cadherin in gastric carcinomas with microsatellite instability
- Concomitant expression of p16INK4a and p14ARF in primary breast cancer and analysis of inactivation mechanisms
- Concurrence of replicative senescence and elevated expression of p16INK4a with subculture-induced but not calcium-induced differentiation in normal human oral …
- Conjunctive p16INK4a Testing Significantly Increases Accuracy in Diagnosing High-Grade Cervical Intraepithelial Neoplasia
- Conspirators in a capital crime: co-deletion of p18INK4c and p16INK4a/p14ARF/p15INK4b in glioblastoma multiforme
- Contrasting behavior of the p18INK4c and p16INK4a tumor suppressors in both replicative and oncogene-induced senescence
- Contribution of p16INK4a to replicative senescence of human fibroblasts
- Controlled induction and targeted elimination of p16INK4a-expressing chondrocytes in cartilage explant culture
- Conventional cytology, visual tests and evaluation of p16INK4a as a biomarker in cervical intraepithelial neoplasia
- COOH-terminal binding protein regulates expression of the p16INK4a tumor suppressor and senescence in primary human cells
- Correction: Induction of p16INK4a Is the Major Barrier to Proliferation when Epstein-Barr Virus (EBV) Transforms Primary B Cells into Lymphoblastoid Cell Lines
- Correction: p16INK4a Expression and Immunologic Aging in Chronic HIV Infection
- Correlation among 16 biological factors [p53, p21waf1, MIB‑1 (Ki‑67), p16INK4a, cyclin D1, E‑cadherin, Bcl‑2, TNF‑α, NF‑κB, TGF‑β, MMP‑7, COX‑2, EGFR …
- Correlation between expression of DNMT3B6s and promoter methylation of tumor suppressor genes p16INK4a and RASSF1A in non-small cell lung cancer
- Correlation between p14ARF/p16INK4a expression and HPV infection in uterine cervical cancer
- Correlation between p21waf1 and p16INK4a expression in hepatocellular carcinoma
- Correlation of abnormal RB, p16INK4a, and p53 expression with 3p loss of heterozygosity, other genetic abnormalities, and clinical features in 103 primary non-small …
- Correlation of p16INK4a immunoexpression and human papillomavirus (HPV) detected by in-situ hybridization in cervical squamous neoplasia
- Correlation of p16INK4a overexpression with human papillomavirus infection in cervical adenocarcinomas
- Correlation of PD-L1 expression with p16INK4a expression in nonoropharyngeal head and neck squamous cell carcinoma.
- Correlations between p16INK4a expression and HPV infection to cervical intraepithelial neoplasia and cervical squamous cell carcinoma
- Correlative immunohistochemistry and molecular genetic study of the inactivation of the p16INK4a genes in astrocytomas.
- Creg1 And Its Enhancement Of p16INK4a-Induced Senescence
- CREG1 enhances p16INK4a-induced cellular senescence
- CSN6 promotes tumorigenesis of gastric cancer by ubiquitin-independent proteasomal degradation of p16INK4a
- CtBP1 is expressed in melanoma and represses the transcription of p16INK4a and Brca1
- CtBP2 contributes to malignant development of human esophageal squamous cell carcinoma by regulation of p16INK4a
- Culturing on Wharton’s jelly extract delays mesenchymal stem cell senescence through p53 and p16INK4a/pRb pathways
- Cumulation of TP53 mutations and p16INK4a/p15INK4B homozygous deletions in human papilloma virus type 16 positive scrotal cancer
- Cyclin D1 and p16INK4a are preferentially expressed in immature and mature myeloma cells, respectively
- Cyclin D1 and p16INK4a expression predict reduced survival in carcinoma of the anterior tongue
- Cyclin E and c‐Myc promote cell proliferation in the presence of p16INK4a and of hypophosphorylated retinoblastoma family proteins
- Cyclin-dependent kinase inhibitor p16INK4a and telomerase may co-modulate endothelial progenitor cells senescence
- Cyclin-dependent kinase inhibitor p16INK4a inhibits phosphorylation of RNA polymerase II by general transcription factor TFIIH
- Cysteine oxidation triggers amyloid fibril formation of the tumor suppressor p16INK4a
- Cytotoxicity of 5-Aza-2′-deoxycytidine against gastric cancer involves DNA damage in an ATM-P53 dependent signaling pathway and demethylation of p16INK4a
- DDB1-CUL4 and MLL1 mediate oncogene-induced p16INK4a activation
- De novo methylation of the p16INK4a gene in early preneoplastic liver and tumors induced by folate/methyl deficiency in rats
- Decreasing expression of the G1-phase inhibitors, p21Cip1 and p16INK4a, promotes division of corneal endothelial cells from older donors
- Decreasing Expression of the G1-Phase Inhibitors, p21Cip1 and p16INK4a, Promotes Division of Corneal Endothelial Cells From Older Donors
- Definition of three minimal deleted regions by comprehensive allelotyping and mutational screening of FHIT,p16INK4a, and p19ARF genes in nasopharyngeal …
- Deletion and altered regulation of p16INK4a and p15INK4b in undifferentiated mouse skin tumors
- Deletion and differential expression of p16INK4a in mouse lung tumors.
- Deletion in p16INK4a and loss of p16 expression in human skin primary and metastatic melanoma cells
- Deletion of one copy of the p16INK4a tumor suppressor gene is implicated as a predisposing factor in pediatric leukemia
- Deletion of p16INK4a/CDKN2 and p15INK4B in human somatic cell hybrids and hybrid-derived tumors
- Deletion of the Ink4-locus (the p16INK4a, p14ARF and p15ink4b genes) predicts relapse in children with ALL treated according to the Nordic protocols …
- Deletion of the p16INK4a Gene in ex Vivo Acute Adult T Cell Lymphoma/Leukemia Cells and Methylation of the p16INK4a Promoter in HTLV Type I-Infected T Cell …
- Deletion of the p16INK4a tumor suppressor and expression of the androgen receptor induce sarcomatoid carcinomas with signet ring cells in the mouse …
- Deletions and Loss of Expression of p16INK4a and P21Waf1 Genes Are Associated With Aggressive Variants of Mantle Cell Lymphomas
- Deletions of the cyclin-dependent kinase inhibitor genes p16INK4a and p15INK4B in non-Hodgkin’s lymphomas
- Depletion of the cdk inhibitor p16INK4a differentially affects proliferation of established cervical carcinoma cells
- Deregulated expression of E2F family members induces S-phase entry and overcomes p16INK4a-mediated growth suppression.
- Deregulated expression of p16INK4a and p53 pathway members in benign and malignant myoepithelial tumours of the salivary glands
- Deregulation of the tumour suppressor genes p14ARF, p15INK4b, p16INK4a and p53 in basal cell carcinoma
- Descriptive study of Expression of p16INK4a in Different Types of Lesions in Uterine Cervix
- Design and characterization of a hyperstable p16INK4a that restores Cdk4 binding activity when combined with oncogenic mutations
- Detecting a Tumor Suppressor Protein (p16INK4a) in Zebrafish (Danio rerio)
- Detecting homozygous deletions in the CDKN2A (p16INK4a)/ARF (p14ARF) gene in urinary bladder cancer using real-time quantitative PCR
- Detection and pathological value of papillomavirus DNA and p16INK4a and p53 protein expression in cervical intraepithelial neoplasia
- Detection of Aberrant p16INK4a Methylation in Sera of Patients With HCV Related Liver Diseases: An Egyptian Study
- Detection of aberrant p16INK4a methylation in sera of patients with HCV-related liver diseases: An Egyptian study
- Detection of aberrant p16INK4a methylation in sera of patients with liver cirrhosis and hepatocellular carcinoma
- Detection of circulating methylated p16INK4a in the serum of Puerto Rican HNSCC patients.
- Detection of HPV16 infection and p16INK4a expression in concurrent cancers from esophagus and gastric cardia in same high-incidence area patient.
- Detection of human papilloma virus (HPV) in liquid-based cervical samples. Correlation with protein p16INK4a expression
- Detection of human papilloma virus subtypes 16 and p16INK4a in invasive squamous cell carcinoma of the fallopian tube and concomitant squamous cell carcinoma …
- Detection of Human papillomavirus and cellular regulators p16INK4a, p53, and NF-kappaB in penile cancer cases in Kenya.
- Detection of methylation in the CpG islands of the p16INK4a, RASSF 1A and methylguanine methyltransferase gene promoters in pancreatic adenocarcinoma
- Detection of p16INK4a in Oropharyngeal and Upper Respiratory tract Squamous cell Carcinoma
- Detection p16INK4a protein in cervical tissues with time-resolved fluoroimmunoassay
- Developing nanobodies to stabilise the tumour suppressor protein p16INK4a
- Development of Novel p16INK4a Mimetics as Anticancer Therapy
- Diagnostic accuracy of p16INK4a immunohistochemistry in oropharyngeal squamous cell carcinomas: A systematic review and meta‐analysis
- Diagnostic Role of RASSF1A and p16INK4a Promoter Gene Hypermethylation in Serum DNA of Lung Cancer Patients: Clinicopathological Significance.
- Diagnostic utility of p16INK4a: a reappraisal of its use in cervical biopsies
- Diagnostic value of p16INK4a in squamous intraepithelial lesion in gynecologic cytology
- Diagnostic value of p16INK4a, Ki‐67, and human papillomavirus L1 capsid protein immunochemical staining on cell blocks from residual liquid‐based gynecologic …
- Die prognostische Bedeutung von nukleärer und zytoplasmatischer p16INK4a-Expression sowie der Expression von E2F1 in gastrointestinalen Stromatumoren (GIST …
- Dietary folate is associated with p16INK4a methylation in head and neck squamous cell carcinoma
- Different expression of p16INK4a and p14ARF in cervical and lung cancers
- Different incidence and pattern of p15INK4b and p16INK4a promoter region hypermethylation in Hodgkin’s and CD30-Positive non-Hodgkin’s lymphomas
- Different p16INK4a and p14ARF Expression Patterns in Acute Myeloid Leukaemia and Normal Blood Leukocytes
- Different patterns of p16INK4a and p53 protein expressions in intraductal papillary-mucinous neoplasms and pancreatic intraepithelial neoplasia
- Differential effects of p19Arf and p16INK4a loss on senescence of murine bone marrow-derived preB cells and macrophages
- Differential Expression of p16INK4a in Azoxymethane‐Induced Mouse Colon Tumorigenesis
- Differential Frequencies of p16INK4a Promoter Hypermethylation, p53 Mutation, and K-ras Mutation in Exfoliative Material Mark the Development of Lung Cancer in …
- Differential retinoblastoma and p16INK4a protein expression in neuroendocrine tumors of the lung
- Differential roles of p16INK4a and p14ARF genes in prognosis of oral carcinoma
- Dioxin-induced immortalization of normal human keratinocytes and silencing of p53 and p16INK4a
- Direct down-regulation of eEF1A2 by Tumor suppressor p16INK4a inhibits cancer cell growth
- Direct evidence from siRNA-directed “knock down” that p16INK4a is required for human fibroblast senescence and for limiting ras-induced epithelial cell proliferation
- Disfigurement of p16INK4a gene expression in development of cervical cancer and study of the mechanism
- Disfigurement of p16INK4a gene expression in development of ovarian cancer and the mechanism
- Disfigurement of p16INK4a gene expression in the development of endometrial diseases
- Disruption of the Multiple Tumor Suppressor Gene MTS1/p16INK4a/CDKN2 by Illegitimate V(D)J Recombinase Activity in T-Cell Acute Lymphoblastic Leukemias
- Disruptive cell cycle regulation involving epigenetic downregulation of Cdkn2a (p16INK4a) in early-stage liver tumor-promotion facilitating liver cell regeneration in rats
- Dissecting the contribution of p16INK4a and the Rb family to the Ras transformed phenotype
- Dissecting the oncogenic consequences of p19Arf/p53-and p16INK4a/pRB-pathway disruption
- Dissection of CDK4-Binding and Transactivation Activities of p34SEI-1 and Comparison between Functions of p34SEI-1 and p16INK4a
- Distinct patterns of inactivation of p15INK4B and p16INK4a characterize the major types of hematological malignancies
- Distinct promoter hypermethylation of p16INK4a, CDH1, and RAR‐beta in intestinal, diffuse–adherent, and diffuse–scattered type gastric carcinomas
- Distinct susceptibility of induction of methylation of p16INK4a and p19arf CpG islands by X-radiation and chemical carcinogen in mice
- Distinctive association of p16INK4a overexpression with penile intraepithelial neoplasia depicting warty and/or basaloid features: a study of 141 cases evaluating a …
- Distinctive crypt shape in a sessile serrated adenoma/polyp: Distribution of Ki67-, p16INK4a-, WNT5A-positive cells and intraepithelial lymphocytes
- DNA copy number aberrations and disruption of the p16INK4a/Rb pathway in radiation-induced and spontaneous rat mammary carcinomas
- DNA methylation and expression of p16INK4a gene in pulmonary adenocarcinoma and anthracosis in background lung
- DNA methylation status of hMLH1, p16INK4a, and CDH1 is not associated with mRNA expression levels of DNA methyltransferase and DNA demethylase in gastric …
- Does p16INK4a expression increase with the number of cell doublings in normal and malignant lymphocytes?
- Double positivity for HPV-DNA/p16INK4a is the biomarker with strongest diagnostic accuracy and prognostic value for human papillomavirus related oropharyngeal …
- Down-regulation of p16INK4a by hYSK1 promotes cancer cell migration under hypoxic conditions
- Downregulation and aberrant promoter methylation of p16INK4a: A possible novel heritable susceptibility marker to retinoblastoma
- Downregulation of p16INK4a inhibits cell proliferation and induces G1 cell cycle arrest in cervical cancer cells
- Dual stain immunohistochemical localization of p16INK4a and ki-67: a synergistic approach to identify clinically significant cervical mucosal lesions
- Duration but not intensity of alcohol and tobacco exposure predicts p16INK4a homozygous deletion in head and neck squamous cell carcinoma
- Dynamic expression of p16INK4a gene in lung fibroblasts of neonatal rats with chronic lung disease.
- Dysregulation of the Bmi‐1/p16INK4a pathway provokes an aging‐associated decline of submandibular gland function
- E47 Governs the MYC-CDKN1B/p27KIP1-RB Network to Growth Arrest PDA Cells Independent of CDKN2A/p16INK4a and Wild-Type p53
- Early deregulation of the p16INK4a-cyclin D1/cyclin-dependent kinase 4-retinoblastoma pathway in cell proliferation-driven esophageal tumorigenesis in zinc-deficient …
- Early loss of proliferative potential of human peritoneal mesothelial cells in culture: the role of p16INK4a-mediated premature senescence
- Effect of 2LMISEN® on Long-Term Hippocampal Neurons Culture as a Screening Senescent Cells Model: p16INK4a and Caspase 3 Quantification
- Effect of 5-aza-2′-deoxycytidine on p16INK4a, p14ARF, p15INK4b Genes Expression, Cell Viability, and Apoptosis in PLC/PRF5 and MIA Paca-2 Cell Lines
- Effect of exogenous p16INK4a and hRb1 genes on cell cycle regulation of osteosarcoma cell
- Effect of human papillomavirus on cell cycle-related proteins p16INK4a, p21waf1/cip1, p53 and cyclin D1 in sinonasal inverted papilloma and laryngeal carcinoma. An …
- Effect of iodine intake on p14ARF and p16INK4a expression in thyroid papillary carcinoma in rats
- Effect of metabolizable peptide p16INK4a on short-lived human tumor cultures
- Effect of p16INK4a on chemosensitivity in nasopharyngeal carcinoma cells.
- Effect of phosphorylation and methylation on the function of the p16INK4a protein in non-small cell lung cancer A549 cells
- Effect of QS Alex 755 nm Laser on the Expression of p16INK4a on the Melanoma Cell Lines
- Effects of CDKN2A (p16INK4a/p14ARF) over-expression on proliferation and migration of human melanoma A375 Cells
- Effects of exogenous p16INK4a on growth of cells with various status of cell-cycle regulators.
- Effects of simian virus 40 T-antigens on normal human mammary epithelial cells reveal evidence for spontaneous alterations in addition to loss of p16INK4a …
- Efficacy evaluation of a test CINtec® p16INK4a in screening for cervical HPV infection
- Efficient immortalization of primary human cells by p16INK4a‐specific short hairpin RNA or Bmi‐1, combined with introduction of hTERT
- EGFR, p16INK4a and E-cadherin immuno-histochemistry and EGFR point mutations analyses in invasive cervical cancer specimens from Moroccan women.
- EGFR, p16INK4a and E-cadherin immuno-histochemistry and EGFR point mutations analyses in invasive cervical cancer specimens from Moroccan women.
- Electron microscopy evidence that cytoplasmic localization of the p16INK4a “nuclear” cyclin-dependent kinase inhibitor (CKI) in tumor cells is specific and not an …
- Elevated p16INK4a expression in human labial salivary glands as a potential correlate of cognitive aging in late midlife
- Endothelial toll‐like receptor 4 maintains lung integrity via epigenetic suppression of p16INK4a
- Enhanced p16INK4a Expression In Cervical Cancer Among HPV Infected Women
- Enzyme-linked Immunosorbent Assay-based Detection of Biomarker Protein p16INK4a in Lysed Cervical Samples
- Enzyme‐linked immunosorbent assay for p16INK4a– a new triage test for the detection of cervical intraepithelial neoplasia?
- EP294 Comparison of triage management between p16INK4a/Ki67 dual staining and HR-HP test in patients with cervical cytology ASC-US and LSIL
- Epigallocatechin-3-gallate and trichostatin A synergistically inhibit human lymphoma cell proliferation through epigenetic modification of p16INK4a
- Epigenetic alteration of p16INK4a gene in dedifferentiation of liposarcoma
- Epigenetic alterations of p15INK4B and p16INK4a genes in pediatric primary myelodysplastic syndrome
- Epigenetic changes in the CDKN2A locus are associated with differential expression of p16INK4a and P14ARF in HPV‐positive oropharyngeal squamous cell …
- Epigenetic inactivation of 14-3-3 σ in oral carcinoma: association with p16INK4a silencing and human papillomavirus negativity
- Epigenetic regulation of p14ARF and p16INK4a expression in cutaneous and uveal melanoma
- Epigenetic regulation of p16INK4a and Arf by JDP2 in cellular senescence
- Epigenetic regulation of p16INK4a-MMP-1 axis in OA-associated senescence-like phenotype and hypertrophy of chondrocytes
- Epigenetic repression of p16INK4a by Latent Epstein-Barr Virus requires the interaction of EBNA3A and EBNA3C with CtBP
- Epigenetic silencing of the p16INK4a tumor suppressor is associated with loss of CTCF binding and a chromatin boundary
- Epithelial Cells Derived from Human Embryonic Stem Cells Display p16INK4a Senescence, Hypermotility, and Differentiation Properties Shared by Many P63+ …
- Epstein-Barr virus and p16INK4a methylation in squamous cell carcinoma and precancerous lesions of the cervix uteri
- Epstein-Barr virus infection correlates with the expression of COX-2, p16INK4a and p53 in classic Hodgkin lymphoma
- Epstein-Barr virus inhibits p16INK4a expression in human fetal nasopharyngeal epithelial cells escaping from the replicative senenscence
- Epstein-Barr virus LMP1 blocks p16INK4a–RB pathway by promoting nuclear export of E2F4/5
- Epstein-Barr virus nuclear antigens 3C and 3A maintain lymphoblastoid cell growth by repressing p16INK4a and p14ARF expression
- Erratum to: RASSF1A, APC, ESR1, ABCB1 and HOXC9, but not p16INK4a, DAPK1, PTEN and MT1G genes were frequently methylated in the stage I non-small cell …
- Estimating clinical outcome of HPV induced cervical lesions by combination of capsid protein L1 and p16INK4a protein detection
- Estimation of Prognoses for Cervical Intraepithelial Neoplasia 2 by p16INK4a Immunoexpression and High-Risk HPV In Situ Hybridization Signal Types
- ETS-dependent p16INK4a and p21waf1/cip1 gene expression upon endothelin-1 stimulation in malignant versus and non-malignant proximal tubule cells
- Evaluation of a new p16INK4a ELISA test and a high‐risk HPV DNA test for cervical cancer screening: Results from proof‐of‐concept study
- Evaluation of a nuclear score for p16INK4a‐stained cervical squamous cells in liquid‐based cytology samples
- Evaluation of an ELISA for p16INK4a as a screening test for cervical cancer
- Evaluation of an Enzyme-linked Immunosorbent Assay-based p16INK4a Detection Assay for the Identification of High-grade Cervical Intraepithelial Neoplasia in …
- Evaluation of biomarkers p16INK4a/ki-67 in cervical cytology for diagnosis of cervical intraepithelial neoplasia
- Evaluation of cervical cone biopsies for coexpression of p16INK4a and Ki‐67 in epithelial cells
- Evaluation of expression of p16INK4a & Survivin in squamous neoplasm of cervix-A 3 years study
- Evaluation of p16INK4a and Ki-67 proteins expression in cervical intraepithelial neoplasia and their correlation with HPV-HR infection
- Evaluation of p16INK4a and pRb expression in cervical squamous and glandular neoplasia
- Evaluation of p16INK4a as a Biomarker in Cervical Intraepithelial Neoplasia
- Evaluation of p16INK4a as a diagnostic tool in the triage of Pap smears demonstrating atypical squamous cells of undetermined significance
- Evaluation of p16INK4a expression in ThinPrep cervical specimens with the CINtec p16INK4a assay: Correlation with biopsy follow‐up results
- Evaluation of p16INK4a immunostaining for the detection of high-grade changes in cervical cytology
- Evaluation of p16INK4a in cervical lesion of premenopausal and postmenopausal women
- Evaluation of p16INK4a overexpression in a large series of cervical carcinomas: concordance with SPF10-LiPA25 PCR
- Evaluation of p16INK4a, minichromosome maintenance protein 2, DNA topoisomerase IIα, ProEX C, and p16INK4a/ProEX C in cervical squamous intraepithelial …
- Evaluation of p16INK4a, minichromosome maintenance protein 2, DNA topoisomerase IIα, ProEx C, and p16INK4a/ProEx C in cervical squamous intraepithelial …
- Evaluation of p16INK4a/Ki‐67 dual stain in comparison with an mRNA human papillomavirus test on liquid‐based cytology samples with low‐grade squamous …
- Evaluation of the expression of p16INK4a by immunohistochemistry in post-neoadjuvant chemotherapy hormone receptor negative breast cancer specimens
- Evaluation of UHRF1 and p16INK4a expression levels in newly diagnosed AML patients
- Evidence for at least three alternative mechanisms targeting the p16INK4a/cyclin D/Rb pathway in penile carcinoma, one of which is mediated by high‐risk human …
- Evidence that P12, a specific variant of p16INK4a, plays a suppressive role in human pancreatic carcinogenesis
- Evidence that senescent human prostate epithelial cells enhance tumorigenicity: cell fusion as a potential mechanism and inhibition by p16INK4a and hTERT
- EVOLUTION OF TUMOR SUPPRESSOR p16INK4a EXPRESSION IN CERVICAL CARCINOMA AMONG IRAQI WOMEN PATIENTS
- Exogenous expression of p16INK4a is associated with decrease in telomerase activity
- Exogenous wild-type p16INK4a gene induces delayed cell proliferation and promotes chemosensitivity through decreased pRB and increased E2F-1 expressions
- Exon 11 mutations, Ki67, and p16INK4a as predictors of prognosis in patients with GIST
- Exploration of tumor suppressors p16INK4a and p14ARF in oral leukoplakias
- Exploring galectin-3-KRASmut-p16INK4a interplay in colorectal cancer
- Expresión de p16INK4a, MCM2/TOPII y REST y estado físico del VPH 16 en el seguimiento de lesiones tempranas del cérvix uterino en mujeres guerrerenses
- Expression and characterization of Syrian golden hamster p16, a homologue of human tumor suppressor p16INK4a
- Expression and clinical significance of p16INK4a in human primary mesangial proliferative glomerulo-nephritis
- Expression and clinical significance of PML, P53 and p16INK4a in lung cancer
- Expression and clinical values of HPV L1 and p16INK4a protein in uterine cervical lesions
- Expression and Promoter Methylation of p16INK4a During Estrogen-Induced Mammary Carcinogenesis in the ACI Rat
- Expression and significance of MCM5 and p16INK4a in cervical squamous cell carcinoma
- Expression and significance of p16INK4a and PTEN in high-risk human papillomavirus-related cervical cancer
- Expression of a p16INK4a-specific ribozyme downmodulates p16INK4a abundance and accelerates cell proliferation
- Expression of ASPP2 and p16INK4a and its relationship with apoptosis in esophageal carcinoma
- Expression of Bcl-2, p16INK4a, and Cyclin D1 Proteins in Squamous Cell Carcinoma of the Lip
- Expression of cell-cycle mediators in ovarian cancer cells after transfection with p16INK4a, p21WAF1/Cip-1, and p53
- Expression of Chr9p21 genes CDKN2B (p15INK4b), CDKN2A (p16INK4a, p14ARF) and MTAP in human atherosclerotic plaque
- Expression of DNA methyltransferase 1 is activated by hepatitis B virus X protein via a regulatory circuit involving the p16INK4a-cyclin D1-CDK 4/6-pRb-E2F1 pathway
- Expression of E6/E7 mRNA from ‘high risk’human papillomavirus in relation to CIN grade, viral load and p16INK4a
- Expression of Fhit, Mlh1, p16INK4a and E-cadherin in early gastric neoplasia: Correlation with histological grade and gastric phenotype
- Expression of human papilloma virus (HPV) and p16INK4a in cervical intraepithelial neoplasia (CIN) and papilloma
- Expression of human papillomavirus L1 capsid protein and tumor suppressor gene p16INK4a and their relevance in cervical lesions
- Expression of p14ARF, p15INK4b, p16INK4a and skp2 increases during esophageal squamous cell cancer progression
- Expression of p14ARF, p16INK4a and p53 in relation to HPV in (pre‐)malignant squamous skin tumours
- Expression of p16INK4a and alterations of the 9p21‐23 chromosome region in non‐small‐cell lung carcinomas: Relationship with tumor growth parameters and …
- Expression of p16INK4a and cervical infection with high-risk human papillomavirus are not related to p53 activity in cervical intraepithelial neoplasia
- Expression of p16INK4a and human papillomavirus 16 with associated risk factors in cervical premalignant and malignant lesions
- Expression of p16INK4a and MIB-1 in relation to histopathology and HPV types in cervical adenocarcinoma
- Expression of p16INK4a and other cell cycle regulator and senescence associated genes in aging human kidney
- Expression of p16INK4a as a biomarker of T‐cell aging in HIV‐infected patients prior to and during antiretroviral therapy
- Expression of p16INK4a but not hypoxia markers or poly adenosine diphosphate‐ribose polymerase is associated with improved survival in patients with pancreatic …
- Expression of p16INK4a compensates for p18Ink4c loss in cyclin-dependent kinase 4/6–dependent tumors and tissues
- Expression of p16INK4a in ameloblastoma: Immunohistochemical and FISH analysis
- Expression of p16INK4a in cervical precancerous lesions is unlikely to be preventable by human papillomavirus vaccines
- Expression of p16INK4a in Endometrioid Cancer Rat Model
- Expression of p16INK4a in gastrointestinal stromal tumours (GISTs): two different forms exist that independently correlate with poor prognosis
- Expression of p16INK4a in mixed squamous cell and glandular papilloma of the lung
- Expression of p16INK4a in nucleus pulposus and its effect on degenerated intervertebral discs
- Expression of p16INK4a in Pap smears containing atypical glandular cells from the uterine cervix
- Expression of p16INK4a in Papanicolaou smears containing atypical squamous cells of undetermined significance from the uterine cervix
- Expression of p16INK4a in peripheral blood T‐cells is a biomarker of human aging
- Expression of p16INK4a in relation to histopathology and viral load of ‘high-risk’HPV types in cervical neoplastic lesions
- Expression of p16INK4a in testis of rhesus monkey during heat stress and testosterone undecanoate induced azoospermia or oligozoospermia☆
- Expression of p16INK4a in various cancer cells
- Expression of p16INK4a induces dominant suppression of glioblastoma growth in situ through necrosis and cell cycle arrest
- Expression of p16INK4a prevents cancer and promotes aging in lymphocytes
- Expression of p16INK4a Protein in Cervical Intraepithelial Neoplasia and Invasive Carcinoma of Uterine Cervix
- Expression of p16INK4a Protein in Colorectal Cancer Patients
- Expression of p16INK4a Protein in Colorectal Cancer Patients
- Expression of p16INK4a variants in senescent human fibroblasts independent of protein phosphorylation
- Expression of p16INK4a, CyclinD1, Ki-67 and HPV infection in cervical squamous cell carcinoma.
- Expression of p16INK4a, p15INK4b, p21WAF1/Clip1 cell cycle inhibitors on blastic cells in patients with acute myeloblastic leukemia (AML) and acute lymphoblastic …
- Expression of p16INK4a, p53, and Rb proteins are independent from the presence of human papillomavirus genes in oral squamous cell carcinoma
- Expression of p16INK4a/p16α and p19ARF/p16β is frequently altered in non-small cell lung cancer and correlates with p53 overexpression
- Expression of p16INK4aSuppresses the Unbounded and Anchorage-Independent Growth of a Glioblastoma Cell Line That Lacks p16INK4a
- Expression of P27, P21WAF/Cip1, and p16INK4a in normal oral epithelium, oral squamous papilloma, and oral squamous cell carcinoma
- Expression of p53, p16INK4a, pRb, p21WAF1/CIP1, p27KIP1, cyclin D1, Ki-67 and HPV DNA in sinonasal endophytic Schneiderian (inverted) papilloma
- Expression of p53, p21WAF1/CIP1, p16INK4a and Ki-67 proteins in serous ovarian tumors
- Expression of survivin and p16INK4a/Cdk6/pRB proteins and induction of apoptosis in response to radiation and cisplatin in meningioma cells
- Expression of the cell cycle regulators p14ARF and p16INK4a in chronic myeloid leukemia
- Expression of the cell cycle regulators p53, p21WAF1/CIP1 and p16INK4a in human endometrial adenocarcinoma
- Expression of the cell-cycle regulatory proteins (pRb, cyclin D1, p16INK4a and cdk4) in human endometrial cancer: correlation with clinicopathological features
- Expression of the p16INK4a and Ki-67 in relation to the grade of cervical intraepithelial neoplasia and high-risk human papillomavirus infection
- Expression of the p16INK4a gene and methylation pattern of CpG sites in the promoter region in rat tumor cell lines
- Expression of the p16INK4a gene is associated closely with senescence of human mesenchymal stem cells and is potentially silenced by DNA methylation during in …
- Expression of the p16INK4a gene product, methylation of the p16INK4a promoter region and expression of the polycomb-group gene BMI-1 in squamous cell lung …
- Expression of the p16INK4a tumor suppressor correlates with adverse clinical outcome in follicular lymphoma
- Expression of the p16INK4a/Cdkn2a gene is prevalently downregulated in human pheochromocytoma tumor specimens
- Expression of the protein marker p16INK4a in the cervix uteri cancer
- Expression of the tumormarker p16INK4a in cytology specimens of the urinary bladder. A new means for early recognition and surveillance of urothelial cancer
- Expression of thymidylate synthase in human cells is an early G1 event regulated by CDK4 and p16INK4a but not E2F
- Expression profiles of p53-, p16INK4a-, and telomere-regulating genes in replicative senescent primary human, mouse, and chicken fibroblast cells
- Expressions of MCM5 and p16INK4a in cervical squamous cell carcinoma
- Expressions of p16INK4a gene and Bmi1 gene in human corneal endothelial cells of different ages
- Expressions of p16INK4a protein in cervical lesion tissues of Mongolian patients and their significances
- Extremely stringent activation of p16INK4a prevents immortalization of uterine cervical epithelial cells without human papillomavirus oncogene expression
- FBXL16 is a novel E2F1-regulated gene commonly upregulated in p16INK4a-and p14ARF-silenced HeLa cells
- Features of replicative senescence induced by direct addition of antennapedia‐p16INK4a fusion protein to human diploid fibroblasts
- Fine-mapping loss of gene architecture at the CDKN2B (p15INK4b), CDKN2A (p14ARF, p16INK4a), and MTAP genes in head and neck squamous cell carcinoma
- Forced expression of the cyclin-dependent kinase inhibitor p16INK4a in leukemic U-937 cells reveals dissociation between cell cycle and differentiation
- Forkhead-box A1 induces cell senescence in endometrial cancer by regulating p16INK4a
- FOXA1 mediates p16INK4a activation during cellular senescence
- Frequency of genetic and epigenetic alterations of p14ARF and p16INK4a in head and neck cancer in a Hungarian population
- Frequency of p16INK4a alterations and k-ras mutations in intrahepatic cholangiocarcinoma of the liver
- Frequency of p16INK4a and P14ARF genes methylation and its impact on bladder cancer cases in north Indian population
- Frequent aberrant methylation of p16INK4a in primary rat lung tumors.
- Frequent alteration of p16INK4a/p14ARF and p53 pathways in the round cell component of myxoid/round cell liposarcoma: p53 gene alterations and reduced p14ARF …
- Frequent alterations of p16INK4a and p14ARF in oral proliferative verrucous leukoplakia
- Frequent alterations of the p14ARF and p16INK4a genes in primary central nervous system lymphomas
- Frequent deletion of p16INK4a/MTS1 and p15INK4b/MTS2 in pediatric acute lymphoblastic leukemia
- Frequent loss of 9p21 (p16INK4a) and other genomic imbalances in human malignant fibrous histiocytoma
- Frequent loss of the p16INK4a gene product in human pituitary tumors
- Frequent methylation of p16INK4a and p14ARF genes implicated in the evolution of chronic myeloid leukaemia from its chronic to accelerated phase
- Frequent methylation of p16INK4a/p14ARF promoters in tumorigenesis of Epstein-Barr virus transformed lymphoblastoid cell lines
- Frequent p16INK4a inactivation is an early and frequent event of intraductal papillary neoplasm of the liver arising in hepatolithiasis
- Frequent p16INK4a promoter hypermethylation in human papillomavirus‐infected female lung cancer in Taiwan
- Frequent promoter hypermethylation of RASSF1A and p16INK4a and infrequent allelic loss other than 9p21 in betel‐associated oral carcinoma in a Vietnamese non …
- Frequent Upregulation of Cyclin D1 and p16INK4a Expression with Low Ki-67 Scores in Multinucleated Giant Cells
- Functional analysis of CDKN2A/p16INK4a 5′-UTR variants predisposing to melanoma
- Functional availability of γ-herpesvirus K-cyclin is regulated by cellular CDK6 and p16INK4a
- Functional impairment of melanoma-associated p16INK4a mutants in melanoma cells despite retention of cyclin-dependent kinase 4 binding
- Functional impairment of p16INK4a due to CDKN2A p. Gly23Asp missense mutation
- Gaba-betaine modulates SIRT1 and p16INK4a expression during high-glucose induced endothelial cell senescence
- GAPDH expression as a measurement of transfection efficiency for p16INK4a gene silencing (siRNA) in senescent human diploid fibroblasts
- Gene Expression Status and Methylation Pattern in Promoter of P15INK4b and p16INK4a in Cord Blood CD34 Stem Cells
- Gene expression status and methylation pattern in promoter of P15INK4b and p16INK4a in cord blood CD34+ stem cells
- Generation and evaluation of chimeric particles consisting of HPV16 L1 and p16INK4a for second generation HPV vaccines
- Generation of HBsAg (S) particles carrying combined HPV-16E7 and p16INK4a epitopes and their immunogenicity in vitro
- Genetic Ablation of p16INK4a Does Not Protect against Cellular Senescence in Mouse Models of Chronic Obstructive Pulmonary Disease/Emphysema
- Genetic alterations of p16INK4a and p14ARF genes in human bladder cancer
- Genetic and epigenetic alterations of the cyclin‐dependent kinase inhibitors p15INK4b and p16INK4a in human thyroid carcinoma cell lines and primary thyroid …
- Genistein induces the p21WAF1/CIP1 and p16INK4a tumor suppressor genes in prostate cancer cells by epigenetic mechanisms involving active chromatin …
- Genomic instability, mutations and expression analysis of the tumour suppressor genes p14ARF, p15INK4b, p16INK4a and p53 in actinic keratosis
- Germline CDKN2A/p16INK4a mutations contribute to genetic determinism of sarcoma
- Germline p16INK4a mutation and protein dysfunction in a family with inherited melanoma.
- Global increase of p16INK4a in APC-deficient mouse liver drives clonal growth of p16INK4a-negative tumors
- Grading immunohistochemical markers p16INK4a and HPV E4 identifies productive and transforming lesions caused by low‐ and high‐risk HPV within high‐grade …
- Green tea polyphenols reactivate silenced tumor suppressor genes, p16INK4a and Cip1/p21, by reducing DNA methylation and increasing histone acetylation in UV …
- GRIM-19 and p16INK4a synergistically regulate cell cycle progression and E2F1-responsive gene expression
- Growth arrest and suppression of tumorigenicity of bladder carcinoma cell lines induced by the P16/CDKN2 (p16INK4a, MTS1) gene and other loci on human …
- H3K27 trimethylation is an early epigenetic event of p16INK4a silencing for regaining tumorigenesis in fusion reprogrammed hepatoma cells
- H3K9me-Enhanced DNA Hypermethylation of the p16INK4a Gene: An Epigenetic Signature for Spontaneous Transformation of Rat Mesenchymal Stem Cells
- Hemizygous or homozygous deletion of the chromosomal region containing the p16INK4a gene is associated with amplification of the EGF receptor gene in …
- Hepatitis B virus X protein induces hypermethylation of p16INK4a promoter via DNA methyltransferases in the early stage of HBV‐associated hepatocarcinogenesis
- Hepatitis B virus X protein overcomes stress-induced premature senescence by repressing p16INK4a expression via DNA methylation
- Hepatitis B virus X protein promotes hypermethylation of p16INK4a promoter through upregulation of DNA methyltransferases in hepatocarcinogenesis
- Hepatocyte growth factor induces redistribution of p21CIP1 and p27KIP1 through ERK-dependent p16INK4a up-regulation, leading to cell cycle arrest at G1 in HepG2 …
- Hereditary TP53 codon 292 and somatic p16INK4a codon 94 mutations in a Li-Fraumeni syndrome family
- HFE polymorphisms influence the response to chemotherapeutic agents via induction of p16INK4a
- High ALDH1, S phase fraction, p16INK4a in esophageal squamous cell carcinoma could predict response to neoadjuvant chemotherapy
- High expression of p16INK4a and low expression of Bmi1 are associated with endothelial cellular senescence in the human cornea
- High frequency deletion of the tumour suppressor gene p16INK4a (MTS1) in human thyroid cancer cell lines
- High frequency methylation of p16INK4a gene during 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis
- High frequency of homozygous deletion and methylation of p16INK4a gene in oral squamous cell carcinomas
- High frequency of loss of heterozygosity on chromosome region 9p21–p22 but lack of p16INK4a/p19arf mutations in Greek patients with basal cell carcinoma …
- High frequency of p16INK4a promoter methylation in NRAS-mutated cutaneous melanoma
- High prevalence of the G101W germline mutation in the CDKN2A (p16INK4a) gene in 62 Italian malignant melanoma families
- High-risk HPV E6/E7 mRNA in situ hybridization in endocervical glandular neoplasia: performance compared with p16INK4a and Ki67 immunochemistry
- High-risk HPV genotypes and p16INK4a expression in a cohort of head and neck squamous cell carcinoma patients in Singapore
- High-risk HPV infection and CIN grade correlates to the expression of c-myc, CD4+, FHIT, E-cadherin, Ki-67, and p16INK4a
- High-risk human papillomavirus DNA test and p16INK4a in the triage of LSIL: a prospective diagnostic study
- High-risk human papillomavirus infection and p16INK4a protein expression in laryngeal lesions
- High‐density methylation of p14ARF and p16INK4a in Epstein‐Barr virus–associated gastric carcinoma
- Histologically normal human mammary epithelia with silenced p16INK4a overexpress COX-2, promoting a premalignant program
- Histone deacetylase 3 (HDAC3) participates in the transcriptional repression of the p16INK4a gene in mammary gland of the female rat offspring exposed to an early …
- Histone deacetylase inhibitor suppression of autoantibody‐mediated arthritis in mice via regulation of p16INK4a and p21WAF1/Cip1 expression
- Histone demethylase KDM2B promotes triple negative breast cancer proliferation by suppressing p15INK4B, p16INK4a, and p57KIP2 transcription
- Histopathological Analysis and Role of p16INK4a as a Diagnostic Marker in Uterine Cervical Neoplasms
- Hmga2 promotes neural stem cell self-renewal in young but not old mice by reducing p16INK4a and p19Arf Expression
- Homozygous codeletion and differential decreased expression of p15INK4b, p16INK4a-alpha and p16INK4a-beta in mouse lung tumor cells.
- Homozygous deletion of CDKN2A (p16INK4a/p14ARF) but not within 1p36 or at other tumor suppressor loci in neuroblastoma
- Homozygous deletion of p16INK4a and tobacco carcinogen exposure in nonsmall cell lung cancer
- Homozygous Deletion of the p16INK4a Gene Occurs More Frequently in CD2+ Than in CD2− T-Cell Acute Lymphoblastic Leukemia
- Homozygous deletions of p16INK4a/MTS1 and p15INK4B/MTS2 genes in glioma cells and primary glioma tissues
- How is the mutational status for tumor suppressors p53 and p16INK4a in MFH of the bone?
- How to measure RNA expression in rare senescent cells expressing any specific protein such as p16INK4a
- Hoxa9 silencing of p16INK4a is essential for murine lymphopoiesis
- HPV 16-associated tonsillar carcinomas show p16INK4a over-expression and an improved prognosis
- HPV DNA genotyping and methylation of gene p16INK4a in cervical LSIL
- HPV DNA, E6* I-mRNA expression and p16INK4a immunohistochemistry in head and neck cancer–How valid is p16INK4a as surrogate marker?
- HPV DNA, E6/E7 mRNA, and p16INK4a detection in head and neck cancers: a systematic review and meta-analysis
- HPV DNA, p16INK4a and mRNA E6* I detection in anogenital cancers
- HPV infection and p16INK4a and TP53 expression in rare cancers of the uterine cervix
- HPV-16 E6 silencing of p16INK4a in human cervical cancer cells
- HPV-related oropharyngeal squamous cell carcinoma: p16INK4a immunohistochemistry or HPV genotyping?
- HPV-related Vulvar Diseases and Perspectives of p16INK4a Immunochemistry: A Review of the Literature
- Hsa‐let‐7g inhibits proliferation of hepatocellular carcinoma cells by downregulation of c‐Myc and upregulation of p16INK4a
- HTLV-1 Tax protein interacts with cyclin-dependent kinase inhibitor p16INK4a and counteracts its inhibitory activity to CDK4.
- HTLV‐1 Tax protein interacts with cyclin‐dependent kinase inhibitor p16INK4a and counteracts its inhibitory activity towards CDK4.
- Human astrocytes exhibit an increased expression of the cellular senescence biomarker p16INK4a in aged human brain and Alzheimer’s Disease
- Human glioblastomas with no alterations of the CDKN2A (p16INK4a, MTS1) and CDK4 genes have frequent mutations of the retinoblastoma gene.
- Human keratinocytes that express hTERT and also bypass a p16INK4a-enforced mechanism that limits life span become immortal yet retain normal growth and …
- Human Keratinocytes That Express hTERT and Also Bypass a p16INK4a-Enforced Mechanism That Limits Life Span Become…
- Human papilloma virus (HPV) status, p16INK4a, and p53 overexpression in epithelial malignant and borderline ovarian neoplasms
- Human Papillomavirus and Overexpression of p16INK4a in Nonmelanoma Skin Cancer
- Human papillomavirus detection and p16INK4a expression in cervical lesions: a comparative study
- Human papillomavirus DNA and p16INK4a expression in concurrent esophageal and gastric cardia cancers
- Human papillomavirus DNA and p16INK4a expression in hypopharyngeal cancer and in relation to clinical outcome, in Stockholm, Sweden
- Human papillomavirus DNA detection, p16INK4a, and oral cavity cancer in a US population
- Human papillomavirus DNA load and p16INK4a expression predict for local control in patients with anal squamous cell carcinoma treated with chemoradiotherapy
- Human papillomavirus genotypes and p16INK4a expression in squamous penile carcinoma in Mexican patients
- Human Papillomavirus genotyping and p16INK4a expression in cervical lesions: a combined test to avoid cervical cancer progression
- Human papillomavirus genotyping by oligonucleotide microarray and p16INK4a expression in uterine cervical intraepithelial neoplasm and in invasive carcinoma in …
- Human papillomavirus infection and immunohistochemical p16INK4a expression as predictors of outcome in penile squamous cell carcinomas
- Human papillomavirus infection and p16INK4a protein expression in vulvar intraepithelial neoplasia and invasive squamous cell carcinoma
- Human Papillomavirus Infection, p16INK4a Expression and Genetic Alterations in Vietnamese Cervical Neuroendocrine Cancer
- Human papillomavirus status and p16INK4a expression in patients with mucosal squamous cell carcinoma of the head and neck in Queensland, Australia
- Human papillomavirus‐associated increase in p16INK4a expression in penile lichen sclerosus and squamous cell carcinoma
- Human papillomavirus, Epstein‐Barr virus, and methylation status of p16INK4a in penile cancer
- Human papillomaviruses, expression of p16INK4a, and early endocervical glandular neoplasia
- Human T-cell leukemia virus type 1 Tax releases cell cycle arrest induced by p16INK4a.
- Hydrogen peroxide induces p16INK4a through an AUF1‐dependent manner
- Hyperemethylation of p16INK4a is associated with cervical neoplasia
- Hypermethylation Analysis of p16INK4a and p15INK4b Promoters in Chronic Lymphocytic Leukaemia Patients and Normal Individuals
- Hypermethylation can selectively silence individual p16INK4a alleles in neoplasia
- Hypermethylation of E-cadherin gene is frequent and independent of p16INK4a methylation in non-small cell lung cancer: potential prognostic implication
- Hypermethylation of hMLH1, HPP1, p14ARF, p16INK4a and APC in primary adenocarcinomas of the small bowel
- Hypermethylation of p16INK4a and P15ink4b genes as a marker of disease in the follow‐up of non‐Hodgkin’s lymphomas
- Hypermethylation of p16INK4a and p15INK4b genes in non-small cell lung cancer
- Hypermethylation of p16INK4a in Korean non-small cell lung cancer patients
- Hypermethylation of promoter regions of the APC1A and p16INK4a genes in relation to prognosis and tumor characteristics in cervical cancer patients
- Hypermethylation of the CDKN2/p16INK4a promotor in thyroid carcinogenesis
- Hypermethylation of the P15INK4b and p16INK4a in agnogenic myeloid metaplasia (AMM) and AMM in leukaemic transformation
- Hypermethylation of the p16INK4a promoter in colectomy specimens of patients with long-standing and extensive ulcerative colitis
- Hypermethylation of tumor suppressor genes (p16INK4a, p14ARF and APC) in adenocarcinomas of the upper gastrointestinal tract
- Hypermethylation-associated inactivation of p14ARF is independent of p16INK4a methylation and p53 mutational status
- hYSK1 promotes cancer cell proliferation and migration through negative regulation of p16INK4a under hypoxic conditions
- Identification and characterization of a novel protein ISOC2 that interacts with p16INK4a
- Identification and sequencing of the Syrian Golden hamster (Mesocricetus auratus) p16INK4a and p15INK4b cDNAs and their homozygous gene deletion in cheek …
- Identification of a splice acceptor site mutation in p16INK4a/p14ARF within a breast cancer, melanoma, neurofibroma prone kindred
- Identification of high‐grade cervical dysplasia by the detection of p16INK4a in cell lysates obtained from cervical samples
- Identification of target genes of the p16INK4a-pRB-E2F pathway
- IL-6 Predicts p16INK4a Expression, Intracellular Tenofovir/Emtricitabine Exposure, and Endogenous Nucleotide Pools in Adults with HIV
- Immortalization of bovine capillary endothelial cells by hTERT alone involves inactivation of endogenous p16INK4a/pRb
- Immortalization of Human Fetal Cells: The Life Span of Umbilical Cord Blood-derived Cells Can Be Prolonged without Manipulating p16INK4a/RB Braking Pathway
- Immuno-Histochemical Study of p16INK4a in Cervical Intraepithelial Neoplasia and Cervical Cancer
- Immunocytochemical colocalization of p16INK4a and Ki‐67 predicts CIN2/3 and AIS/adenocarcinoma Pilot studies
- Immunocytochemical detection of p16INK4a protein for the identification of patients at risk of cervical cancer
- Immunocytochemical detection of p16INK4a protein in scraped cervical cells.
- Immunocytochemical expression of p16INK4a and Ki-67 in cytologically negative and equivocal pap smears positive for oncogenic human papillomavirus
- Immunocytochemical expression of P53, PTEN, FAS (CD95), p16INK4a and HPV L1 major capsid proteins in ThinPrep cervical samples with squamous intraepithelial …
- Immunocytochemical staining of p16INK4a protein as an adjunct test in equivocal liquid‐based cytology
- Immunocytochemical staining of p16INK4a protein from conventional Pap test and its association with human papillomavirus infection
- Immunocytochemical Studies of Cyclin D1 and p16INK4a in Acute Lymphoblastic Leukemic Patients
- Immunocytochemistry (p16INK4a) as an additional examination for cytological specimens Class III D (Munich Classification II)
- Immunocytochemistry of p16INK4a in liquid-based cervicovaginal specimens with modified Papanicolaou counterstaining
- Immunoexpression of p16INK4a, Rb and TP53 proteins in bronchiolar columnar cell dysplasia (BCCD) in lungs resected due to primary non-small cell lung cancer.
- Immunofluorescence expression of Ki-67, p53 and cyclin inhibitors (p16INK4a, p21 and p27) in low-grade cervical lesions versus high-grade cervical lesions …
- Immunohistochemical Analysis of Abnormal p16INK4a Protein Expression in Human Breast Cancer.
- Immunohistochemical analysis of p16INK4a, p14ARF, p18INK4c, p21CIP1, p27KIP1 and p73 expression in 271 meningiomas correlation with tumor grade and …
- Immunohistochemical analysis of pRb2/p130, VEGF, EZH2, p53, p16INK4a, p27KIP1, p21WAF1, Ki‐67 expression patterns in gastric cancer
- Immunohistochemical analysis of thymidylate synthase, p16INK4a, cyclin‐dependent kinase 4 and cyclin D1 in colorectal cancers receiving preoperative chemotherapy …
- Immunohistochemical and molecular study of p16INK4a expression in pituitary adenoma
- Immunohistochemical detection of p16INK4a in leukoplakia and oral squamous cell carcinoma
- Immunohistochemical detection of p16INK4a in liquid‐based cytology specimens on cell block sections
- Immunohistochemical detection of the cyclin-dependent kinase inhibitor 2/multiple tumor suppressor gene 1 (CDKN2/MTS1) product p16INK4a in archival human …
- Immunohistochemical Evaluation of p16INK4a, E-Cadherin, and Cyclin D1 Expression in Melanoma and Spitz Tumors
- Immunohistochemical Evaluation of Thymidylate Synthase (TS) and p16INK4a in Advanced Colorectal Cancer: Implication of TS Expression in 5-FU-based Adjuvant …
- Immunohistochemical expression of cyclin D1, p16INK4a, p21WAF1, and Ki-67 correlates with the severity of cervical neoplasia
- Immunohistochemical expression of Ki-67, Cyclin D1, p16INK4a, and Survivin as a predictive tool for recurrence and progression-free survival in papillary urothelial …
- Immunohistochemical Expression of p16INK4a and bcl-2 According to HPV Type and to the Progression of Cervical Squamous Intraepithelial Lesions
- Immunohistochemical expression of p16INK4a in inflammatory, preneoplastic and neoplastic cervical lesions
- Immunohistochemical expression of p16INK4a protein as a helpful marker of a subset of potentially malignant oral epithelial lesions: study on a series with long‐term …
- Immunohistochemical expression of p16INK4a protein in oral lichen planus
- Immunohistochemical Expression of the Tumor Suppressor Protein p16INK4a in Cervical Adenocarcinoma
- Immunohistochemical staining for p16INK4a selectively detects human papillomavirus-related premalignant and malignant vulvar lesions
- Immunohistochemical survey of p16INK4a expression in normal human adult and infant tissues.
- Immunohistochemistry: Poster# 232 THE UTILITY OF p16INK4a EXPRESSION IN UTERINE CERVICAL BIOPSIES REPORTED NEGATIVE AND POSITIVE FOR …
- Immunohistological Expression of p16INK4a is Commonly Present Both in Benign and Malignant Sweat Gland Neoplasias.
- Immunostaining for p16INK4a used as a conjunctive tool improves interobserver agreement of the histologic diagnosis of cervical intraepithelial neoplasia
- Immunostaining for polycomb group protein EZH2 and senescent marker p16INK4a may be useful to differentiate cholangiolocellular carcinoma from ductular reaction …
- Immunostaining of p16INK4a/Ki-67 and L1 capsid protein on liquid-based cytology specimens obtained from ASC-H and LSIL-H cases
- Impact of methylation of the p16INK4a gene on the prognosis ofhead and neck squamous cell carcinoma patients
- Impact of novel CDKN2A/p16INK4a 5’UTR variants predisposing to melanoma on p16 translational regulation
- Impact of p16INK4a and p15INK4B on human hepatocellular carcinoma cell proliferation and apoptosis
- Impact of p16INK4a Immunohistochemistry Staining on Interobserver Agreement on the Diagnosis of Cervical Intraepithelial Neoplasia
- Impact of utilizing p16INK4a immunohistochemistry on estimated performance of three cervical cancer screening tests
- Impaired cell cycle check-point control and increased tumorigenesis by loss of p16INK4a
- Impaired inhibition of NF-κB activity by melanoma-associated p16INK4a mutations
- Impaired Processing of DNA Photoproducts and Ultraviolet Hypermutability With Loss of p16INK4a or p19ARF
- Implication of polycomb members Bmi-1, Mel-18, and Hpc-2 in the regulation of p16INK4a, p14ARF, h-TERT, and c-Myc expression in primary breast carcinomas
- Implication of USP22 in the regulation of BMI-1, c-Myc, p16INK4a, p14ARF, and cyclin D2 expression in primary colorectal carcinomas
- Implications of genetic and epigenetic alterations of CDKN2A (p16INK4a) in cancer
- Improving Early Diagnosis of Cervical Cancer Lesions Using p16INK4a Biomarkers on Cellblocks from Cervical Smears
- In silico analysis of structural and functional consequences in p16INK4a by deleterious nsSNPs associated CDKN2A gene in malignant melanoma
- In vitro and in vivo tumor growth inhibition by a p16‐mimicking peptide in p16INK4a‐defective, pRb‐positive human melanoma cells
- In vitro drug resistance and prognostic impact of p16INK4a/P15INK4B deletions in childhood T‐cell acute lymphoblastic leukaemia
- In vitro study examining the effect of sub‐lethal QS 755 nm lasers on the expression of p16INK4a on melanoma cell lines
- Inactivation mechanisms and growth suppressive effects of p16INK4a in Asian esophageal squamous carcinoma cell lines
- Inactivation of multiple tumor-suppressor genes involved in negative regulation of the cell cycle, MTS1/p16INK4a/CDKN2, MTS2/p15INK4B, p53, and Rb genes in …
- Inactivation of p16INK4a (inhibitor of cyclin-dependent kinase 4A) immortalizes primary human keratinocytes by maintaining cells in the stem cell compartment
- Inactivation of p16INK4a by CpG hypermethylation is not a frequent event in colorectal cancer
- Inactivation of p16INK4a expression in malignant mesothelioma by methylation
- Inactivation of p16INK4a, with retention of pRB and p53/p21cip1 function, in human MRC5 fibroblasts that overcome a telomere-independent crisis during …
- Inactivation of the Dlc1 gene cooperates with downregulation of p15INK4b and p16INK4a, leading to neoplastic transformation and poor prognosis in human cancer
- Inactivation of the p14ARF, p15INK4B and p16INK4a genes is a frequent event in human oral squamous cell carcinomas
- Inactivation of the p16INK4a gene by methylation is not a frequent event in sporadic ovarian carcinoma
- Inactivation of tumor suppressor genes p15INK4b and p16INK4a in primary cutaneous B cell lymphoma
- Incidence and Clinical Significance of CDKN2/MTS1/p16INK4a ND MTS2/P15ink4B Gene Deletions in Childhood Acute Lymphoblastic Leukemia
- Increased CDK4 protein expression predicts a poor prognosis in mucosal melanoma associated with the p16INK4a-CDK4-pRb pathway
- Increased expression of senescence markers p14ARF and p16INK4a in breast cancer is associated with an increased risk of disease recurrence and poor survival …
- Increased Expression of Senescence‐Associated Cell Cycle Inhibitor p16INK4a in Deteriorating Renal Transplants and Diseased Native Kidney
- Increased Expression of the Cyclin dependent Kinase Inhibitor p16INK4a in Helicobacter pylori-associated Chronic Gastritis
- Increased p16INK4a-expressing senescent bile ductular cells are associated with inadequate response to ursodeoxycholic acid in primary biliary cholangitis
- Increased γ-tubulin expression and p16INK4a promoter methylation occur together in preinvasive lesions and carcinomas of the breast
- Induction of p16INK4a and p19ARF by TGFβ1 contributes to growth arrest and senescence response in mouse keratinocytes
- Induction of p16INK4a is the major barrier to proliferation when Epstein-Barr virus (EBV) transforms primary B cells into lymphoblastoid cell lines
- Induction of p16INK4a mediated by β‐catenin in a TCF4‐independent manner: Implications for alterations in p16INK4a and pRb expression during trans …
- Induction of pRb degradation by the human papillomavirus type 16 E7 protein is essential to efficiently overcome p16INK4a-imposed G1 cell cycle Arrest
- Induction of the tumor-suppressor p16INK4a within regenerative epithelial crypts in ulcerative colitis
- Influence of human papillomavirus and p16INK4a on treatment outcome of patients with anal cancer
- Infrequent alterations of the p16INK4a gene in liver cancer
- Infrequent alternations of RB pathway (Rb-p16INK4a-cyclinD1) in adenoid cystic carcinoma of salivary glands.
- Infrequent mutations of p16INK4a and p15INK4B genes in human pituitary adenomas
- Inhibition of p16INK4a Protects Against Myocardial Ischemia/Reperfusion Injury
- Inhibition of pRb phosphorylation and cell cycle progression by an antennapedia-p16INK4a fusion peptide in pancreatic cancer cells
- Inhibition of T-cell acute lymphoblastic leukemia proliferation in vivo by re-expression of the p16INK4a tumor suppressor gene
- Inhibition of the H3K4 methyltransferase MLL1/WDR5 complex attenuates renal senescence in ischemia reperfusion mice by reduction of p16INK4a
- INK4a gene expression and methylation in primary breast cancer: overexpression of p16INK4a messenger RNA is a marker of poor prognosis
- Insertional mutagenesis in mice deficient for p15Ink4b, p16INK4a, p21Cip1, and p27Kip1 reveals cancer gene interactions and correlations with tumor phenotypes
- INSIGHTS AND PITFALLS OF A SELECTIVE p16INK4a IMMUNOHISTOCHEMICAL TESTING STRATEGY FOR ORAL SQUAMOUS CELL CARCINOMA AND …
- Interobserver reproducibility of cytologic p16INK4a/Ki‐67 dual immunostaining in human papillomavirus‐positive women
- Interplay between Homeobox proteins and Polycomb repressive complexes in p16INK4a regulation
- Interpretation of p16INK4a/Ki‐67 dual immunostaining for the triage of human papillomavirus‐positive women by experts and nonexperts in cervical cytology
- Intrinsic cooperation between p16INK4a and p21Waf1/Cip1 in the onset of cellular senescence and tumor suppression in vivo
- Introduction of p16INK4a inhibits telomerase activity through transcriptional suppression of human telomerase reverse transcriptase expression in human gliomas
- Invade or proliferate? Two contrasting events in malignant behavior governed by p16INK4a and an intact Rb pathway illustrated by a model system of basal cell …
- Invasion of normal human fibroblasts induced by v-Fos is independent of proliferation, immortalization, and the tumor suppressors p16INK4a and p53
- Inverse correlation between p16INK4a expression and NF-κB activation in melanoma progression
- Investigating Diagnostic Problems of CIN 1 and 2 Associated with High-Risk HPV by Combining the Novel Molecular Biomarker PanHPV E4 with p16INK4a
- Investigation of germline PTEN, p53, p16INK4a/p14ARF, and CDK4 alterations in familial glioma
- Investigation of p16INK4a and P14RF genes expression in different phase of Chronic Myeloid Leukemia (CML)
- Involvement of Bmi-1 gene in the development of gastrointestinal stromal tumor by regulating p16INK4a/p14ARF gene expressions: An in vivo and in vitro study
- Involvement of CDKN2 (p16INK4a/MTS1) and p15INK4B/MTS2 in human leukemias and lymphomas
- Ionizing Radiation Induces Hematopoietic Stem Cell Senescence and Long-Term Bone Marrow Suppression in a p16INK4a/Arf-Independent manner
- Is p16INK4a expression more useful than human papillomavirus test to determine the outcome of atypical squamous cells of undetermined significance-categorized …
- Is p16INK4a overexpression a reliable biomarker for oncogenic human papillomavirus infection in normal tonsils?
- Is p16INK4a protein expression in oral ST lesions a reliable precancerous marker?
- Is the expression of p16INK4a and galectin-3 correlated with disease progression of cervical neoplasia?
- Ischemia dysregulates DNA methyltransferases and p16INK4a methylation in human colorectal cancer cells
- JMJD3 Plays Essential Roles in the Maintenance of Hematopoietic Stem Cells and Leukemic Stem Cells through the Regulation of p16INK4a
- Jun dimerization protein 2 controls hypoxia‐induced replicative senescence via both the p16INK4a‐pRb and Arf‐p53 pathways
- JunB suppresses cell proliferation by transcriptional activation of p16INK4a expression
- K‐ras oncogene subtype mutations are associated with survival but not expression of p53, p16INK4a, p21WAF‐1, cyclin D1, erbB‐2 and erbB‐3 in resected …
- KDM6A regulates cell proliferation, invasion and apoptosis by transcriptional inhibits p16INK4a
- KLRG1 impairs CD4+ T cell responses via p16INK4a and p27kip1 pathways: role in hepatitis B vaccine failure in individuals with hepatitis C virus infection
- Knockout of Canopy 2 activates p16INK4a pathway to impair cardiac repair
- Knockout of p16INK4a promotes aggregative growth of dermal papilla cells
- Lack of mutation at p16INK4a gene but expression of aberrant p16INK4a RNA transcripts in human ovarian carcinoma
- Lack of p16INK4a over expression in penile squamous cell carcinoma is associated with recurrence after lymph node dissection
- Latent membrane protein 1 encoded by Epstein–Barr virus induces telomerase activity via p16INK4a/Rb/E2F1 and JNK signaling pathways
- Local immune response depends on p16INK4a status of primary tumor in vulvar squamous cell carcinoma
- Long-term cultured IL-2-dependent T cell lines demonstrate p16INK4a overexpression, normal pRb/p53, and upregulation of cyclins E or D2
- Long‐term arsenic exposure induces histone H3 Lys9 dimethylation without altering DNA methylation in the promoter region of p16INK4a and down‐regulates its …
- Long‐term growth arrest of PUVA‐treated fibroblasts in G2/M in the absence of p16INK4a, p21CIP1 or p53
- Loss of 9p leads to p16INK4a down‐regulation and enables RB/E2F1‐dependent cell cycle promotion in gastrointestinal stromal tumours (GISTs)
- Loss of heterozygosity of CDKN2A (p16INK4a) and RB1 tumor suppressor genes in testicular germ cell tumors
- Loss of p16 protein expression associated with methylation of the p16INK4a gene is a frequent finding in Hodgkin’s disease.
- Loss of p16INK4a expression and homozygous CDKN2A deletion are associated with worse outcome and younger age in thymic carcinomas
- Loss of p16INK4a expression correlates with decreased survival in pediatric osteosarcomas
- Loss of p16INK4a expression is associated with vascular endothelial growth factor expression in squamous cell carcinoma of the esophagus
- Loss of p16INK4a Function Rescues Cellular Senescence Induced by Telomere Dysfunction
- Loss of p16INK4a gene renders mice more susceptible to DMBA-induced mammary carcinogenesis
- Loss of p16INK4a results in increased glucocorticoid receptor activity during fibrosarcoma development
- Loss of p16INK4a stimulates aberrant mitochondrial biogenesis through a CDK4/Rb-independent pathway
- Loss of the hSNF5 gene concomitantly inactivates p21CIP/WAF1 and p16INK4a activity associated with replicative senescence in A204 rhabdoid tumor cells
- Loss of the p16INK4a and p15INK4b genes, as well as neighboring 9p21 markers, in sporadic melanoma
- Low frequency of p16INK4a alterations in insulinomas
- Low p16INK4a expression associated with high expression of cancer stem cell markers predicts poor prognosis in cervical cancer after radiotherapy
- Low p16INK4a Expression in Early Passage Human Prostate Basal Epithelial Cells Enables Immortalization by Telomerase Expression Alone
- Low prevalence of p53, p16INK4a and Ha‐ras tumour‐specific mutations in low‐graded actinic keratosis
- Lower expression of p14ARF and p16INK4a correlates with higher DNMT3B expression in human oesophageal squamous cell carcinomas
- Lower specific micronutrient intake in colorectal cancer patients with tumors presenting promoter hypermethylation in p16INK4a, p14ARF and hMLH1
- LRIG1‑2 and LMO7 immunoreactivity in vulvar squamous cell carcinoma: Association with prognosis in relation to HPV‑DNA and p16INK4a status
- Management of HPV-Related Cervical Disease: Role of p16INK4a Immunochemistry. Review of the Literature
- Mangiferin induces islet regeneration in aged mice through regulating p16INK4a
- Mechanisms Of Human Epithelial Cell Immortalization And p16INK4a Induced Telomere-independent Senescence
- Mechanisms of inactivation of p14ARF, p15INK4b, and p16INK4a genes in human esophageal squamous cell carcinoma
- Mechanisms of inactivation of the p16INK4a gene in leiomyosarcoma of soft tissue: decreased p16 expression correlates with promoter methylation and poor …
- Mechanisms of MEOX1 and MEOX2 regulation of the cyclin dependent kinase inhibitors p21CIP1/WAF1 and p16INK4a in vascular endothelial cells
- Melanin Accumulation Accelerates Melanocyte Senescence by a Mechanism Involving p16INK4a/CDK4/pRB and E2F1
- Methionyl-tRNA synthetase (MRS) controls CDK4 stabiltiy in p16INK4a negative cancer
- Methylation and expression of gene p16INK4a and RB in breast carcinoma
- Methylation and expression of gene p16INK4a and RB in gastric carcinomas
- Methylation and expression of the p16INK4a tumor suppressor gene in multiple myeloma
- Methylation and messenger RNA expression of p15INK4b but not p16INK4a are independent risk factors for ovarian cancer
- Methylation and mRNA expression of the p15INK4b, p16INK4a, BRCA1 and hMLH1 genes in ovarian cancer
- Methylation of CpG islands of p16INK4a and cyclinD1 overexpression associated with progression of intraductal proliferative lesions of the breast
- Methylation of p16INK4a and mitotic arrest defective protein 2 (MAD2) genes in gastric marginal-zone B-cell lymphomas
- Methylation of p16INK4a in primary gynecologic malignancy
- Methylation of p16INK4a promoters occurs in vivo in histologically normal human mammary epithelia
- Methylation of specific CpG sites in the promoter region could significantly down‐regulate p16INK4a expression in gastric adenocarcinoma
- Methylation of the p16INK4a gene in multiple myeloma
- Methylation of the p16INK4a promoter is associated with malignant behavior in abdominal extra-adrenal paragangliomas but not pheochromocytomas
- Methylation of the p16INK4a tumor suppressor gene 5′-CpG island in breast cancer
- Methylation status analysis of cell cycle regulatory genes (p16INK4a, p15INK4B, p21Waf1/Cip1, p27Kip1 and p73) in natural killer cell disorders
- Methylation status of p14ARF and p16INK4a as detected in pancreatic secretions
- Methylation status of p14ARF, p15INK4b, and p16INK4a genes in human hepatocellular carcinoma
- Methylation status of p16INK4a in human papillomavirus-associated cancer of oral cavity and oropharynx in northeastern Thailand
- Methylation, LOH and mutational analysis of p16INK4a and p15INK4B genes in primary and metastatic melanoma: 322
- Microarray-based method for detecting methylation changes of p16INK4a gene 5′-CpG islands in gastric carcinomas
- MicroRNA miR‐24 promotes cell proliferation by targeting the CDKs inhibitors p27Kip1 and p16INK4a
- MMP-9 short interfering RNA induced senescence resulting in inhibition of medulloblastoma growth via p16INK4a and mitogen-activated protein kinase pathway
- Modeling ASXL1 mutation revealed impaired hematopoiesis caused by derepression of p16INK4a through aberrant PRC1-mediated histone modification
- Modeling ASXL1 mutation revealed myelodysplasia caused by derepression of p16INK4a through aberrant PRC1-mediated histone modification
- Modulation of cdk2, cyclin D1, p16INK4a, p21WAF and p27Kip1 expression in endothelial cells by TNF/IFN gamma.
- Modulation of p16INK4a activity by Hsp90, Cdc37 and CRM1 influences the progression of preneoplastic lesions in rats with different predisposition to liver cancer …
- Modulation of the expression of p16INK4a and p14ARF by hnRNP A1 and A2 RNA binding proteins: Implications for cellular senescence
- Molecular and functional alterations associated with repression of tumor suppressor p16INK4a during immortalization of human endothelial cells
- Molecular detection of TP53, Ki-Ras and p16INK4a promoter methylation in plasma of patients with colorectal cancer and its association with prognosis …
- Molecular features of primary mediastinal B‐cell lymphoma: involvement of p16INK4a, p53 and c‐myc
- Molecular Genetic Analysis in B-cell Lymphomas: A Focus on the p53 Pathway and p16INK4a
- Molecular targeting of neuroblastoma with a novel p16INK4a transporter system
- Monitoring tumorigenesis and senescence in vivo with a p16INK4a-luciferase model
- Morphologic characteristics of p16INK4a-positive cells in cervical cytology samples.
- MOZ‐Mediated Repression of p16INK4a Is Critical for the Self‐Renewal of Neural and Hematopoietic Stem Cells
- MTHFR, MTR, and MTRR polymorphisms in relation to p16INK4a hypermethylation in mucosa of patients with colorectal cancer
- Multiple abnormalities of the p16INK4a-pRb regulatory pathway in cultured melanoma cells.
- Multiple mechanisms of p16INK4a inactivation in non-small cell lung cancer cell lines
- Multiple primary tumors as an indicator for p16INK4a germline mutations in pancreatic cancer patients?
- Mutant p53 collaborating with K-ras gene mutations and p16INK4a promoter methylation result in an age-related demographic shift in spontaneous lung tumor …
- Mutation of p16INK4a and p15INK4b genes of human bronchial epithelial cells malignantly transformed by cyclophosphamide and thiotepa
- Mutation profile of the p53, fhit, p16INK4a/p19ARF and H-ras genes in Indian breast carcinomas.
- Mutational analysis of genes p14ARF, p15INK4b, p16INK4a, and PTEN in human nervous system tumors
- Mutational analysis of N-ras, p53, CDKN2A (p16INK4a), p14ARF, CDK4, and MC1R genes in human dysplastic melanocytic naevi
- Mutational analysis of N-ras, p53, p16INK4a, p14ARF and CDK4 genes in primary human malignant mesotheliomas
- Mutational Analysis of p53, p21WAF1 and p16INK4a in Human Cervical Carcinomas
- Mutational analysis of the CDKN2 (MTS1/p16INK4a) gene in primary B-cell lymphomas
- Mutational analysis of the N-ras, p53, p16INK4a, CDK4, and MC1R genes in human congenital melanocytic naevi
- Mutational and methylation analysis of the cyclin‐dependent kinase 4 inhibitor (p16INK4a) gene in chronic lymphocytic leukemia
- Mutational effects on the p16INK4a tumor suppressor protein
- Mutations in Nf2 and p16INK4a synergize to promote meningioma development in mice
- Mutations in the CDKN2A ( p16INK4a ) gene in microdissected sporadic primary melanomas
- Mutations of the cell cycle regulatory genes p16INK4a and p21WAF1 and the metastasis-inducing gene S100A4 are infrequent and unrelated to p53 tumour …
- N-ethyl-N-nitrosourea (ENU)-Induced Meningiomatosis and Meningioma in p16INK4a/p19ARF Tumor Suppressor Gene-Deficient Mice
- N-ras oncogene–induced gene expression in human hematopoietic progenitor cells: Upregulation of p16INK4a and p21CIP1/WAF1 correlates with myeloid …
- Nano polythionine-based electrochemiluminescence biosensor for detection of the p16INK4a gene using RuAg@ AuNPs core-shell nanocomposites as DNA labels
- Natural History of Meningioma Development in Mice Reveals: A Synergy of Nf2 and p16INK4a Mutations
- No metastatic cervical adenocarcinomas in a series of p16INK4a-positive mucinous or endometrioid advanced ovarian carcinomas: an analysis of the AGO Ovarian …
- No p16INK4a/CDKN2/MTS1 mutations independent of p53 status in soft tissue sarcomas
- Nuclear p16INK4a expression predicts enhanced radiation response in head and neck cancers
- Obesity and p16INK4a downregulation activate breast adipocytes and promote their protumorigenicity
- Obesity-induced destabilization of p16INK4a promotes the procarcinogenic effects of breast stromal adipocytes through miR-141/miR-146b-5p-dependent inhibition of …
- Obligate roles for p16INK4a and p19Arf-p53 in the suppression of murine pancreatic neoplasia
- Oncogene-induced senescence does not require the p16INK4a or p14ARF melanoma tumor suppressors
- Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
- OP235: A comparative study of p16INK4a immunohistochemical expression in oral and oropharyngeal sccs
- Oval cell proliferation in p16INK4a expressing mouse liver is triggered by chronic growth stimuli
- Over-expression of CDKIs p15INK4b, p16INK4a and p21CIP1/WAF1 genes mediate growth arrest in human osteosarcoma cell lines.
- Over‐expression of polycomb group protein EZH2 relates to decreased expression of p16INK4a in cholangiocarcinogenesis in hepatolithiasis
- Overexpression of p16INK4a and p14ARF in haematological malignancies
- Overexpression of p16INK4a as a specific marker for dysplastic and neoplastic epithelial cells of the cervix uteri
- Overexpression of p16INK4a as an indicator for human papillomavirus oncogenic activity in cervical squamous neoplasia
- Overexpression of p16INK4a correlates with high expression of p73 in breast carcinomas
- Overexpression of p16INK4a in liquid‐based specimens (SurePath™) as marker of cervical dysplasia and neoplasia
- Overexpression of p16INK4a in Merkel cell carcinoma
- Overexpression of p16INK4a in urothelial carcinoma in situ is a marker for MAPK-mediated epithelial-mesenchymal transition but is not related to human …
- Overexpression of p16INK4a regulates the Wnt/β‑catenin signaling pathway in pancreatic cancer cells
- Overexpression of p16INK4a serves as prognostic marker in squamous cell vulvar cancer patients treated with radiotherapy irrespective of HPV-status
- Overexpression of the cell cycle inhibitor p16INK4a in high-grade prostatic intraepithelial neoplasia predicts early relapse in prostate cancer patients
- Overexpression of the Cell Cycle Inhibitor p16INK4a Promotes a Prothrombotic Phenotype Following Vascular Injury in Mice
- P‐22 p16INK4a AS A MARKER FOR CERVICAL DYSKARYOSIS IN THINPREP® LIQUID BASED CYTOLOGY SAMPLES
- P1-004: Role of cytology accompanied by the study of the occurrence of p16INK4a and O6-methylguanine-DNA transferase (MGMT) promoter methylation in the cells …
- p14ARF and p16INK4a promoter methylation in ulcerative colitis-related carcinogenesis
- p14ARF and p16INK4a, two products of the same gene, are differently expressed in cervical intraepithelial neoplasia
- p14ARF methylation is independent of p16INK4a methylation and aberrant p53 expression in gastric cancer
- p14ARF, p15INK4b and p16INK4a Methylation Status in Chronic Myelogenous Leukemia
- p14ARF,p15INK4b, and p16INK4amethylation status in chronic myelogenous leukemia
- p14arf/p16INK4a and p15ink4b Gene Expression Profile by Real Time Quantitative PCR at Diagnosis Predicts for Clinical Outcome in Multiple Myeloma Patients.
- p15INK4b, p14ARF, and p16INK4a inactivation in sporadic and neurofibromatosis type 1-related malignant peripheral nerve sheath tumors
- p16INK4a adenovirus-mediated gene therapy for human head and neck squamous cell cancer.
- p16INK4a alterations in chronic pancreatitis—indicator for high-risk lesions for pancreatic cancer
- p16INK4a and CDH13 hypermethylation in tumor and serum of non‐small cell lung cancer patients
- p16INK4a and histology-specific methylation of CpG islands by exposure to tobacco smoke in non-small cell lung cancer
- p16INK4a and HPV L1 immunohistochemistry is helpful for estimating the behavior of low-grade dysplastic lesions of the cervix uteri
- p16INK4a and Ki-67 immunostaining on cell blocks from residual ThinPrep material is helpful in identifying significant preneoplastic cervical lesions
- p16INK4a and Ki-67 measurement predict progression of cervical low-grade squamous intraepithelial lesion
- p16INK4a and Ki67 expression in normal, dysplastic and neoplastic uterine cervical epithelium and human papillomavirus (HPV) infection
- p16INK4a and laminin-5γ2 chain expression during the progression of cervical neoplasia
- p16INK4a and low-grade cervical intraepithelial neoplasia. Diagnostic and therapeutic implications
- p16INK4a and MIB-1: An immunohistochemical expression in preneoplasia and neoplasia of the cervix
- p16INK4a and p14ARF expression pattern by immunohistochemistry in human papillomavirus-related cervical neoplasia
- p16INK4a and p14ARF gene promoter hypermethylation as prognostic biomarker in oral and oropharyngeal squamous cell carcinoma: a review
- p16INK4a and p14ARF methylation as a potential biomarker for human bladder cancer
- p16INK4a and p14ARF tumor suppressor genes are commonly inactivated in cutaneous squamous cell carcinoma
- p16INK4a and p14ARF Tumor Suppressor Pathways Are Deregulated in Malignant Rhabdoid Tumors
- p16INK4a and p15INK4B gene deletions in primary leukemias
- p16INK4a and p15INK4b gene promoter methylation in cervical cancer patients
- p16INK4a and p15INK4B in senescence, immortalization and cancer: Gene transfer by adenovirus vectors
- p16INK4a and p19Arf: terrible twins
- p16INK4a and p19INK4d mRNA expression in neuroglial tumours: correlation with Ki67 proliferation index.
- p16INK4a and p21Waf1/Cip1 expression correlates with clinical outcome in vulvar carcinomas
- p16INK4a and p53 deficiency cooperate in tumorigenesis
- p16INK4a and ProEx C Immunostains Facilitate Differential Diagnosis of Hyperchromatic Crowded Groups in Liquid-Based Papanicolaou Tests with Menstrual …
- p16INK4a and retinoic acid modulate rhoA and GFAP expression during induction of a stellate phenotype in U343 MG‐A astrocytoma cells
- p16INK4a and survivin: Diagnostic and prognostic markers in cervical intraepithelial neoplasia and cervical squamous cell carcinoma
- p16INK4a and the control of cellular proliferative life span
- p16INK4a as a complementary marker of high‐grade intraepithelial lesions of the uterine cervix. I: Experience with squamous lesions in 189 consecutive cervical …
- p16INK4a as a marker for cervical dyskaryosis: CIN and cGIN in cervical biopsies and ThinPrep™ smears
- p16INK4a as a progression/regression tumour marker in LSIL cervix lesions: our clinical experience
- p16INK4a as a proliferation marker unrelated to HPV expression in odontogenic cysts and tumors
- p16INK4a as a second effector of the telomere damage pathway
- p16INK4a as a surrogate biomarker for human papillomavirus‐associated oropharyngeal carcinoma: Consideration of some aspects
- p16INK4a as a tumor suppressor with therapeutic applicability
- p16INK4a as an adjunct marker in liquid‐based cervical cytology
- p16INK4a as an adjunct test in cervical cytology.
- p16INK4a as an adjunct test in liquid-based cytology.
- p16INK4a correlates to human papillomavirus presence, response to radiotherapy and clinical outcome in tonsillar carcinoma
- p16INK4a deficiency promotes IL-4–induced polarization and inhibits proinflammatory signaling in macrophages
- p16INK4a deletion in cells of the intervertebral disc affects their matrix homeostasis and senescence associated secretory phenotype without altering onset of …
- p16INK4a deletion switches emphysema to fibrosis in mouse
- p16INK4a down-regulation activates breast stromal adipocytes.
- p16INK4a downregulation is involved in immortalization of primary human prostate epithelial cells induced by telomerase
- p16INK4a enhances the migration and metastasis phenotype of hepatocellular carcinoma cells
- p16INK4a enhances the transcriptional and the apoptotic functions of p53 through DNA‐dependent interaction
- p16INK4a exerts an anti-inflammatory effect through accelerated IRAK1 degradation in macrophages
- p16INK4a exon 1 alpha knockout in mouse embryonic stem cells
- p16INK4a expression adenovirus vector to suppress pancreas cancer cell proliferation
- p16INK4a Expression Analysis as an Ancillary Tool for Cytologic Diagnosis of Urothelial Carcinoma
- p16INK4a expression and absence of activated B-RAF are independent predictors of chemosensitivity in melanoma tumors
- p16INK4a expression and breast cancer risk in women with atypical hyperplasia
- p16INK4a expression and clinicopathologic parameters in renal cell carcinoma
- p16INK4a Expression and immunologic aging in Chronic HIV infection
- p16INK4a expression as a potential prognostic marker in cervical pre-neoplastic and neoplastic lesions
- p16INK4a expression as a potential prognostic marker in cervical precancerous and cancerous lesions in Morocco
- p16INK4a expression as biomarker for HPV 16-related vulvar neoplasias
- p16INK4a expression begins early in human colon neoplasia and correlates inversely with markers of cell proliferation
- p16INK4a expression decreases during imiquimod treatment of anal intraepithelial neoplasia in human immunodeficiency virus‐infected men and correlates with the …
- p16INK4a Expression does not predict the outcome of cervical intraepithelial neoplasia grade 2
- p16INK4a expression in actinic keratosis and Bowen’s disease
- p16INK4a expression in basal-like breast carcinoma
- p16INK4a expression in benign and malignant melanocytic conjunctival lesions
- p16INK4a Expression in Cervical Lesions Correlates with Histologic Grading-a Tertiary Level Medical Facility Based Retrospective Study
- p16INK4a expression in cervical premalignant and malignant lesions
- p16INK4a expression in cytology of ascites and response to chemotherapy in advanced ovarian cancer
- p16INK4a expression in invasive vulvar squamous cell carcinoma
- p16INK4a expression in malignant melanomas with or without a contiguous naevus remnant: a clue to their divergent pathogenesis?
- p16INK4a expression in patients with penile cancer.
- p16INK4a Expression in Porokeratosis
- p16INK4a expression in squamous cell carcinomas of the vagina and the vulva in Tunisian women
- p16INK4a expression in undifferentiated carcinoma of the uterus does not exclude its endometrial origin
- p16INK4a expression is frequently decreased and associated with 9p21 loss of heterozygosity in sporadic melanoma
- p16INK4a expression is frequently increased in periorbital and ocular squamous lesions
- p16INK4a expression is increased through 12-lipoxygenase in high glucose-stimulated glomerular mesangial cells and type 2 diabetic glomeruli
- p16INK4a expression is related to grade of CIN and high-risk human papillomavirus but does not predict virus clearance after conization or disease outcome
- p16INK4a expression mediated by recombinant adenovirus can induce senescence of A549 cells
- p16INK4a expression, human papillomavirus, and survival in head and neck cancer
- p16INK4a gene alterations are frequent in lesions of mycosis fungoides
- p16INK4a Gene and Hematological Malignancies
- p16INK4a gene homozygous deletions in human acute leukaemias with alterations of chromosome 9
- p16INK4a Gene Inactivation by Deletions, Mutations, and Hypermethylation Is Associated With Transformed and Aggressive Variants of Non-Hodgkin’s Lymphomas
- p16INK4a gene promoter hypermethylation in mucosa as a prognostic factor for patients with colorectal cancer
- p16INK4a genetic and epigenetic profiles differ in relation to age and site in head and neck squamous cell carcinomas
- p16INK4a Hypermethylation detected by fluorescent methylation-specific PCR in plasmas from non-small cell lung cancer
- p16INK4a hypermethylation is associated with hepatitis virus infection, age, and gender in hepatocellular carcinoma
- p16INK4a immunocytochemical analysis is an independent prognostic factor in childhood acute lymphoblastic leukemia
- p16INK4a immunocytochemistry in liquid-based cervical cytology: Is it feasible for clinical use?
- p16INK4a immunocytochemistry on cell blocks as an adjunct to cervical cytology: Potential reflex testing on specially prepared cell blocks from residual liquid …
- p16INK4a immunocytochemistry versus human papillomavirus testing for triage of women with minor cytologic abnormalities A systematic review and meta‐analysis
- p16INK4a immunocytochemistry/immunohistochemistry: need for scoring uniformization to be clinically useful in gynecological pathology
- p16INK4a immunoexpression and HPV in situ hybridization signal patterns: potential markers of high-grade cervical intraepithelial neoplasia
- p16INK4a immunoexpression profile in HPV-oral lesions from HIV-infected patients
- p16INK4a immunoexpression: surrogate marker of high-risk HPV and high-grade cervical intraepithelial neoplasia
- p16INK4a immunohistochemical and histopathologic study of Pap test cases interpreted as HSIL without CIN2-3 identification in subsequent cervical specimens
- p16INK4a Immunohistochemical Overexpression in Premalignant and Malignant Oral Lesions Infected with Human Papillomavirus
- p16INK4a immunohistochemical staining and predictive value for progression of cervical intraepithelial neoplasia grade 1: A prospective study in China
- p16INK4a immunohistochemical staining may be helpful in distinguishing branchial cleft cysts from cystic squamous cell carcinomas originating in the oropharynx
- p16INK4a Immunohistochemistry for Detection of Human Papilloma Virus-Associated Penile Squamous Cell Carcinoma is Superior to in-Situ Hybridization
- p16INK4a immunohistochemistry improves interobserver agreement in the diagnosis of cervical intraepithelial neoplasia
- p16INK4a immunohistochemistry improves the reproducibility of the histological diagnosis of cervical intraepithelial neoplasia in cone biopsies
- p16INK4a Immunohistochemistry in Cervical Biopsy Specimens: A Systematic Review and Meta-Analysis of the Interobserver Agreement
- p16INK4a immunohistochemistry is a promising biomarker to predict the outcome of low grade cervical intraepithelial neoplasia: comparison study with HPV …
- p16INK4a immunohistochemistry is superior to HPV in situ hybridization for the detection of high-risk HPV in atypical squamous metaplasia
- p16INK4a immunostaining as an alternative to histology review for reliable grading of cervical intraepithelial lesions
- p16INK4a immunostaining but lack of human papilloma virus type 16 in cutaneous squamous cell carcinoma and basal cell carcinoma: a report from West Iran
- p16INK4a immunostaining identifies occult CIN lesions in HPV-positive women
- p16INK4a immunostaining in cytological and histological specimens from the uterine cervix: a systematic review and meta-analysis
- p16INK4a immunostaining is a strong indicator for high‐risk‐HPV‐associated oropharyngeal carcinomas and dysplasias, but is unreliable to predict low‐risk‐HPV …
- p16INK4a Impairs Homologous Recombination
- p16INK4a impairs homologous recombination–mediated DNA repair in human papillomavirus–positive head and neck tumors
- p16INK4a in cellular senescence
- p16INK4a in Melanocyte Senescence and Differentiation
- p16INK4a in oral squamous cell carcinomas—a correlation with biological behaviors: immunohistochemical and FISH analysis
- p16INK4a in routine practice as a marker of cervical epithelial neoplasia
- p16INK4a inactivation mechanisms in non-small-cell lung cancer patients occupationally exposed to asbestos
- p16INK4a induces differentiation and apoptosis in erythroid lineage cells
- p16INK4a induces senescence and inhibits EMT through microRNA‐141/microRNA‐146b‐5p‐dependent repression of AUF1
- p16INK4a influences the aging phenotype in the living skin equivalent
- p16INK4a inhibits histologic progression and angiogenic signaling in Min colon tumors
- p16INK4a inhibits the pro‐metastatic potentials of osteosarcoma cells through targeting the ERK pathway and TGF‐β1
- p16INK4a inhibits the proliferation of osteosarcoma cells through regulating the miR-146b-5p/TRAF6 pathway
- p16INK4a interferes with Abelson virus transformation by enhancing apoptosis
- p16INK4a is a marker of good prognosis for primary invasive penile squamous cell carcinoma: a multi-institutional study
- p16INK4a is a prognostic marker in resected ductal pancreatic cancer: an analysis of p16INK4a, p53, MDM2, an Rb
- p16INK4a is a robust in vivo biomarker of cellular aging in human skin
- p16INK4a is a surrogate biomarker for a subset of human papilloma virus‐associated dysplasias of the uterine cervix as determined on the Pap smear
- p16INK4a is a surrogate marker for high-risk and malignant cervical lesions in the presence of human papillomavirus
- p16INK4a is a tumor autoantigen in HR-HPV induced cancers
- p16INK4a is a useful marker for the diagnosis of adenocarcinoma of the cervix uteri and its precursors: an immunohistochemical study with immunocytochemical …
- p16INK4a Is a β-Catenin Target Gene and Indicates Low Survival in Human Colorectal Tumors
- p16INK4a is not a Reliable Screening Marker of HPV Infection in Esophageal Squamous Cell Carcinoma: Evidence from a Meta-Analysis
- p16INK4a is Overexpressed in H. pylori‐Associated Gastritis and is Correlated with Increased Epithelial Apoptosis
- p16INK4a is regularly expressed in Hodgkin’s disease: comparison with retinoblastoma, p53 and MDM2 protein status, and the presence of Epstein-Barr virus.
- p16INK4a is required for cisplatin resistance in cervical carcinoma SiHa cells
- p16INK4a is required for hSNF5 chromatin remodeler-induced cellular senescence in malignant rhabdoid tumor cells
- p16INK4a is superior to high‐risk human papillomavirus testing in cervical cytology for the prediction of underlying high‐grade dysplasia
- p16INK4a lesions are common, early abnormalities that undergo clonal expansion in Barrett’s metaplastic epithelium
- p16INK4a loss and sensitivity in KSHV associated primary effusion lymphoma
- p16INK4a mediates age-related changes in mesenchymal stem cells derived from human dental pulp through the DNA damage and stress response
- p16INK4a mediates cyclin dependent kinase 4 and 6 inhibition in senescent prostatic epithelial cells
- p16INK4a methylation in serum as a follow-up marker for recurrence of colorectal cancer
- p16INK4a modulates p53 in primary human mammary epithelial cells
- p16INK4a negatively regulates Leptin through miR-141 and miR-146b-5p in breast stromal adipocytes
- p16INK4a or p19Arf loss contributes to Tal1-induced leukemogenesis in mice
- p16INK4a over-expression sensitizes HPV (-) HNSCC to radiation through down-regulation of USP7
- p16INK4a overexpression and human papillomavirus infection in small cell carcinoma of the uterine cervix
- p16INK4a overexpression and p16/Ki‐67 dual labeling versus conventional urinary cytology in the evaluation of urothelial carcinoma
- p16INK4a overexpression and survival in osteosarcoma patients: a meta analysis
- p16INK4a overexpression as a predictor of survival in ocular surface squamous neoplasia
- p16INK4a Overexpression in Cervical Biopsies Collected from Women with Normal and Equivocal Pap Smears
- p16INK4a overexpression in precancerous and cancerous lesions of the uterine cervix in Tunisian women
- p16INK4a overexpression independent of Human Papilloma Virus (HPV) infection in rare subtypes of endometrial carcinomas
- p16INK4a Overexpression is Associated with Poor Clinical Outcome in Ovarian Carcinoma
- p16INK4a overexpression is frequently detected in tumour‐free tonsil tissue without association with HPV
- p16INK4a overexpression is not linked to oncogenic human papillomaviruses in patients with high‐grade urothelial cancer cells
- p16INK4a overexpression predicts lymph node metastasis in cervical carcinomas
- p16INK4a overexpression predicts translational active human papillomavirus infection in tonsillar cancer
- p16INK4a Peptide mimetics identified via virtual screening
- p16INK4a played a critical role in exacerbating acute tubular necrosis in acute kidney injury
- p16INK4a point mutations and promoter hypermetylation in bronchial preneoplastic lesions.
- p16INK4a polymorphism and ANRIL expression in human breast cancer
- p16INK4a polymorphism: associations with tumour progression in patients with sporadic colorectal cancer
- p16INK4a positive cells in human skin are indicative of local elastic fiber morphology, facial wrinkling, and perceived age
- p16INK4a positively regulates cyclin D1 and E2F1 through negative control of AUF1
- p16INK4a Positively Regulates p21WAF1 Expression by suppressing AUF1-dependent mRNA decay
- p16INK4a prevents centrosome dysfunction and genomic instability in primary cells
- p16INK4a prevents the activation of aged quiescent dentate gyrus stem cells by physical exercise
- p16INK4a promoter hypermethylation in oral scrapings of oral squamous cell carcinoma risk patients
- p16INK4a promoter hypermethylation is associated with invasiveness and prognosis of oral squamous cell carcinoma in an age-dependent manner
- p16INK4a Promoter hypermethylation of non‐tumorous tissue adjacent to gastric cancer is correlated with glandular atrophy and chronic inflammation
- p16INK4a promoter is hypermethylated at a high frequency in esophageal adenocarcinomas
- p16INK4a promoter methylation and 9p21 allelic loss in colorectal carcinomas: relation with immunohistochemical p16INK4a expression and with tumor budding
- p16INK4a promoter methylation and protein expression in breast fibroadenoma and carcinoma
- p16INK4a promoter methylation facilitates p53 inactivation in oral squamous cell carcinoma in Taiwan.
- p16INK4a promoter mutations are frequent in primary sclerosing cholangitis (PSC) and PSC-associated cholangiocarcinoma
- p16INK4a Promotes Differentiation and Inhibits Apoptosis of JKB Acute Lymphoblastic Leukemia Cells
- p16INK4a protein expression is associated with poor survival of the breast cancer patients after CMF chemotherapy
- p16INK4a protein is a specific molecular biomarker of breast cancer
- p16INK4a represses breast stromal fibroblasts migration/invasion and their VEGF-A-dependent promotion of angiogenesis through Akt inhibition
- p16INK4a sensitizes human leukemia cells to FAS-and glucocorticoid-induced apoptosis via induction of BBC3/Puma and repression of MCL1 and BCL2
- p16INK4a status and response to induction low-dose fractionated radiation in advanced head and neck cancer
- p16INK4a subcellular expression patterns in colorectal adenocarcinoma, adenoma and non-neoplastic tissue samples
- p16INK4a suppresses BRCA1-deficient mammary tumorigenesis
- p16INK4a suppression by glucose restriction contributes to human cellular lifespan extension through SIRT1-mediated epigenetic and genetic mechanisms
- p16INK4a suppression of lung adenocarcinoma by Bmi-1 in the presence of p38 activation
- p16INK4a translation suppressed by miR-24
- p16INK4a tumor suppressor function in lung cancer cells involves cyclin-dependent kinase 2 inhibition by Cip/Kip protein redistribution
- p16INK4a tumor suppressor gene expression and CD3ϵ deficiency but not pre-TCR deficiency inhibit TAL1-linked T-lineage leukemogenesis
- p16INK4a upregulation mediated by SIX6 defines retinal ganglion cell pathogenesis in glaucoma
- p16INK4a upregulation mediated by TBK1 induces retinal ganglion cell senescence in ischemic injury
- p16INK4a-A possible marker in HPV persistence screening
- p16INK4a-Expressing Mesenchymal Stromal Cells Restore the Senescence-Clearance-Regeneration Sequence that is Impaired in Chronic Muscle Inflammation
- p16INK4a-expressing mesenchymal stromal cells restore the senescence–clearance–regeneration sequence that is impaired in chronic muscle inflammation
- p16INK4a-independence of Epstein–Barr virus-induced cell proliferation and virus latency
- p16INK4a-PTEN, E-cadherin, Bcl-2 and Ki-67 expression in prostate cancer: Its relationship with the metastatic potential and known prognostic factors
- p16INK4a‐induced senescence is disabled by melanoma‐associated mutations
- p16INK4a‐mediated suppression of telomerase in normal and malignant human breast cells
- p16INK4a–alterations in primary angiosarcoma of the liver
- p16INK4a—Is the future of cervical cancer screening rosy?
- p16INK4a, a senescence marker, influences tenofovir/emtricitabine metabolite disposition in HIV‐infected subjects
- p16INK4a, a surrogate marker of HPV infection and prognosis for head and neck cancer, delays DNA damage repair and enhances radiation response
- p16INK4a, a tumor suppressor protein with a subtle but efficient role
- p16INK4a, CDC6, and MCM5: predictive biomarkers in cervical preinvasive neoplasia and cervical cancer
- p16INK4a, NAD+, and Sestrins: New Targets for Combating Aging‐Related Chronic Illness?
- p16INK4a, not only a G1 inhibitor?
- p16INK4a, p53, EGFR expression and KRAS mutation status in squamous cell cancers of the anus: correlation with outcomes following chemo-radiotherapy
- p16INK4a: a central player in cellular senescence and a promising aging biomarker in elderly cancer patients
- p16INK4a: a potential diagnostic adjunct for prediction of high-grade cervical lesions in liquid-based cytology: with HPV testing and histological correlation
- p16INK4a: A surrogate marker of high‐risk human papillomavirus infection in squamous cell carcinoma of the nasal vestibule
- p16INK4a/CDKN2 expression and its relationship with oral squamous cell carcinoma is our current knowledge enough?
- p16INK4a/exon 2 mutations in squamous cell carcinoma of the head and neck region
- p16INK4a/KI-67 immunocytochemistry in improving the predictive value for high grade cervical intraepithelial (≥ CIN2) lesions in pap smear
- p16INK4a/Ki‐67 co‐expression specifically identifies transformed cells in the head and neck region
- p16INK4a/Ki‐67 dual labelling as a marker for the presence of high‐grade cancer cells or disease progression in urinary cytopathology
- p16INK4a/p19Arf Involves Function of Age-related Pancreatic β Cells
- p16INK4aexpression after chemotherapy in older women with early-stage breast cancer.
- p21 is associated with cyclin D1, p16INK4a and pRb expression in resectable non-small cell lung cancer.
- P3. 208 The infection with human papillomavirus (HPV) type 16 features greater chance to p16INK4a gene methylation in cervical lesions compared to other viral …
- P32 Prospective study on human papillomavirus significance in oral dysplasias in association with clinical parameters and p16INK4a expression
- p38 MAPK and JNK antagonistically control senescence and cytoplasmic p16INK4a expression in doxorubicin-treated endothelial progenitor cells
- p53 and p16INK4a/p19Arf loss promotes different pancreatic tumor types from PYMT-expressing progenitor cells
- p53 but not p16INK4a induces growth arrest in retinoblastoma-deficient hepatocellular carcinoma cells
- p53 Deficiency leads to compensatory up-regulation of p16INK4a
- P53, p15INK4B, p16INK4a and p57KIP2 mutations during the progression of chronic myeloid leukemia.
- Padrão de metilação do gene p16INK4a e de infecções por HPV de alto risco acompanham a evolução de lesões cervicais
- Paradoxical down-regulation of p16INK4a mRNA with advancing age in acute myeloid leukemia
- PD‑L1 expression is associated with p16INK4a expression in non‑oropharyngeal head and neck squamous cell carcinoma
- Pediatric histiocytic sarcoma clonally related to precursor B‐cell acute lymphoblastic leukemia with homozygous deletion of CDKN2A encoding p16INK4a
- Performance of in silico tools for the evaluation of p16INK4a (CDKN2A) variants in CAGI
- Performance of p16INK4a ELISA as a primary cervical cancer screening test among a large cohort of HIV-infected women in western Kenya: a 2-year cross …
- Performance of p16INK4a immunocytochemistry as a marker of anal squamous intraepithelial lesions
- Performance of p16INK4a-cytology, HPV mRNA, and HPV DNA testing to identify high grade cervical dysplasia in women with abnormal screening results
- Phage display specific p16INK4a binding peptide for ex vivo cancer cells imaging
- Phase I/IIa study of therapeutic p16INK4a vaccination in patients with HPV-associated cancers.
- Phase I/IIa trial targeting p16INK4a by peptide vaccination in patients with human papillomavirus-associated cancer.
- Pioglitazone promotes preadipocyte proliferation by downregulating p16INK4a
- Piwil2 expressed in various stages of cervical neoplasia is a potential complementary marker for p16INK4a
- Point mutations in TP53 but not in p15Ink4b and p16INK4a genes represent poor prognosis factors in acute adult T cell leukemia/lymphoma
- Polymorphism of p16INK4a gene and rare mutation of p15INK4b gene exon2 in primary hepatocarcinoma
- Polymorphisms in promoter sequences of MDM2, p53, and p16INK4a genes in normal Japanese individuals
- Possible associations among expression of p14ARF, p16INK4a, p21WAF1/CIP1, p27KIP1, and p53 accumulation and the balance of apoptosis and cell …
- Possible involvement of hMLH1, p16INK4a and PTEN in the malignant transformation of endometriosis
- Poster 15: Disruption of the p16INK4a-CDK4-pRB Tumor Suppressor Pathway and Telomerase-Mediated Immortalization Is Sufficient to Initiate the Malignant …
- Potential diagnostic use of p16INK4a, a new marker that correlates with dysplasia in oral squamoproliferative lesions
- pRB family proteins are required for H3K27 trimethylation and Polycomb repression complexes binding to and silencing p16INK4a tumor suppressor gene
- pRb, but not p107 or p130, is required for full induction of p16INK4a in human mammary epithelial cells
- Predicting functional significance of cancer‐associated p16INK4a mutations in CDKN2A
- Prediction of clinical outcome using p16INK4a immunocytochemical expression in low-grade squamous intraepithelial lesions and high-risk HPV-positive …
- Predictive significance of the alterations of p16INK4a, p14ARF, p53, and proliferating cell nuclear antigen expression in the progression of cervical cancer
- Predictive value of p16INK4a and Ki-67 immunohistochemical staining in expectant management of cervical intraepithelial neoplasia grade 2
- Predictive value of the combined p16INK4a and Ki-67 Immunocytochemistry in low-grade squamous Intraepithelial lesions
- Premature senescence of balding dermal papilla cells in vitro is associated with p16INK4a expression
- Prevalence of aberrant methylation of p14ARF over p16INK4a in some human primary tumors
- Prevalence of human papillomavirus DNA and p16INK4a in penile cancer and penile intraepithelial neoplasia: a systematic review and meta-analysis
- Prevalence of human papillomavirus16 DNA and p16INK4a protein in oral squamous cell carcinoma: A systematic review and meta-analysis
- Primary cilium-dependent and-independent Hedgehog signaling inhibits p16INK4a
- Primary Squamous Cell Carcinoma of the Upper Genital Tract: Utility of p16INK4a Expression and HPV DNA Status in its Differential Diagnosis from Extended …
- Primary squamous cell carcinoma of the vagina: human papillomavirus detection, p16INK4a overexpression and clinicopathological correlations
- Pro-inflammatory effects of different MWCNTs dispersions in p16INK4a-deficient telomerase-expressing human keratinocytes but not in human SV-40 immortalized …
- Proanthocyanidins reactivate silenced tumor suppressor genes p16INK4a and Cip1/p21 by reducing DNA methylation and increasing histone acetylation in human …
- Procedure for immunocytochemical detection of p16INK4a antigen in thin-layer, liquid-based specimens.
- Prognostic and predictive value of koilocytosis, expression of e6 hpv types 16/18, p16INK4a, p53 in locally advanced squamous cell carcinomas of oral cavity and …
- Prognostic implications of cyclins (D1, E, A), cyclin‐dependent kinases (CDK2, CDK4) and tumor‐suppressor genes (pRb, p16INK4a) in childhood acute …
- Prognostic markers of high-grade squamous intraepithelial lesions: the role of p16INK4a and high-risk human papillomavirus
- Prognostic significance of expression patterns of c-erbB-2, p53, p16INK4a, p27KIP1, cyclin D1 and epidermal growth factor receptor in oesophageal adenocarcinoma …
- Prognostic significance of high-risk human papillomavirus and p16INK4a in patients with esophageal squamous cell carcinoma
- Prognostic significance of overexpressed p16INK4a in esophageal squamous cell carcinoma: a meta-analysis
- Prognostic significance of overexpressed p16INK4a in patients with cervical cancer: a meta-analysis
- Prognostic significance of p14ARF, p15INK4b, and p16INK4a inactivation in malignant peripheral nerve sheath tumors
- Prognostic significance of p16INK4a alteration for Ewing sarcoma: A meta‐analysis
- Prognostic significance of p16INK4a alteration in soft tissue sarcomas: A meta-analysis
- Prognostic significance of p16INK4a alterations and 9p21 loss of heterozigosity in locally advanced laryngeal squamous cell carcinoma
- Prognostic significance of p16INK4a and human papillomavirus in patients with oropharyngeal cancer treated on TROG 02.02 phase III trial
- Prognostic significance of p16INK4a expression and integrated human papillomavirus oncogen transcripts in dysplastic lesions of the uterine cervix
- Prognostic significance of p16INK4a hypermethylation in non-small cell lung cancer is evident by quantitative DNA methylation analysis
- Prognostic significance of p16INK4a/p53 in Tunisian patients with breast carcinoma
- Prognostic significance of p21WAF1/CIP1, p16INK4a and CD44s in tongue cancer
- Prognostic significance of p27KIP1 expression in resected non–small cell lung cancers: Analysis in combination with expressions of p16INK4a, pRB, and p53
- Prognostic value of overexpressed p16INK4a in vulvar cancer: a meta-analysis
- Prognostic value of p16INK4a and p14ARF gene hypermethylation in human colon cancer
- Prognostic value of p16INK4a as a marker of clinical evolution in patients with cervical intraepithelial neoplasia grade 3 (CIN 3) treated by cervical conization
- Prognostic value of p16INK4a expression in lung adenocarcinoma.
- Progression of actinic keratosis to squamous cell carcinoma of the skin correlates with deletion of the 9p21 region encoding the p16INK4a tumor suppressor
- Promoter and histone methylation and p16INK4a gene expression in colon cancer
- Promoter hypermethylation and quantitative expression analysis of CDKN2A (p14ARF and p16INK4a) gene in esophageal squamous cell carcinoma
- Promoter hypermethylation of p16INK4a, E-cadherin, O6-MGMT, DAPK and FHIT in adenocarcinomas of the esophagus, esophagogastric junction and proximal …
- Promoter hypermethylation of p16INK4a, p14ARF, CyclinD2 and Slit2 in serum and tumor DNA from breast cancer patients
- Promoter Hypermethylation of Tumor-Suppressor Genes p16INK4a, RASSF1A, TIMP3, and PCQAP/MED15 in Salivary DNA as a Quadruple Biomarker Panel for Early …
- Promoter hypermethylation: a common cause of reduced p16INK4a expression in uveal melanoma
- Promoter methylation and loss of p16INK4a gene expression in head and neck cancer
- Promoter methylation of p16INK4a, hMLH1, and MGMT in liquid-based cervical cytology samples compared with clinicopathological findings and HPV presence
- Promoter methylation of p16INK4a, RASSF1A, and DAPK is frequent in salivary adenoid cystic carcinoma
- Promoter methylation of p16INK4a, RASSF1A, and RAR2b genes in tumor DNA from patients with breast cancer (BC) in correlation with clinical recurrence.
- Promoter methylations of p16INK4a and p14ARF genes in early and advanced gastric cancer. Correlations of the modes of their occurrence with histologic type
- Prostaglandin E2 receptor 2 overexpression in squamous cell carcinoma of the lung correlates with p16INK4a methylation and an unfavorable prognosis
- Protein expression of the tumor suppressors p16INK4a and p53 and disease progression in recurrent respiratory papillomatosis
- PROTEIN p16INK4a IMMUNOHISTOCHEMICAL EXPRESSION IN ADENOCARCINOMA OF THE ESOPHAGUS
- Proteomic analysis of p16INK4a‐binding proteins
- PTEN controls β‐cell regeneration in aged mice by regulating cell cycle inhibitor p16INK4a
- Pyrosequencing® assays to study promoter CpG site methylation of the O6-MGMT, hMLH1, p14ARF, p16INK4a, RASSF1A, and APC1A genes
- Qualification of a p16INK4a immunohistochemistry (IHC) assay for determination of HPV status in archival squamous cell carcinoma of the head and neck (SCCHN) …
- Qualitative Detection of p16INK4a Protein as a Surrogate Biomarker in Invasive Squamous Cell Carcinoma of the Cervix
- Quantitative analysis of CDKN2A methylation, mRNA, and p16INK4a protein expression in children and adolescents with Burkitt lymphoma: Biological and clinical …
- Quantitative analysis of tumor-derived methylated p16INK4a sequences in plasma, serum, and blood cells of hepatocellular carcinoma patients
- Quantitative assessment of aberrant p16INK4a methylation in ovarian cancer: a meta-analysis based on literature and TCGA datasets
- Quantitative evaluation of p16INK4a promoter methylation using pyrosequencing in de novo diffuse large B-cell lymphoma
- Quercetin is able to demethylate the p16INK4a gene promoter
- Radionuclides in cigarettes may lead to carcinogenesis via p16INK4a inactivation
- RASSF1A, APC, ESR1, ABCB1 and HOXC9, but not p16INK4a, DAPK1, PTEN and MT1G genes were frequently methylated in the stage I non-small cell lung cancer …
- Ratio of Expression of p16INK4a to p14ARF Correlates with the Progression of Non‐small Cell Lung Cancer
- Rb and p16INK4a expression in resected non-small cell lung tumors
- Re-establishment of the expression of p16INK4a in the p16INK4a deficient SCL-II cell line recovers the G1/S cell cycle arrest and influences the apoptotic response …
- Re-expression of hSNF5/INI1/BAF47 in pediatric tumor cells leads to G 1 arrest associated with induction of p16INK4a and activation of RB
- Re: Biologic and Biochemical Analyses of p16INK4a Mutations From Primary Tumors
- Re: Oda et al. Frequent alteration of p16INK4a/p14ARF and p53 pathways in the round cell component of myxoid/round cell liposarcoma: p53 gene alterations and …
- Reactivation of methylation-silenced tumor suppressor gene p16INK4a by nordihydroguaiaretic acid and its implication in G1 cell cycle arrest
- Reactivation of tumor suppressor p16INK4a
- Reactive oxygen species promotes cellular senescence in normal human epidermal keratinocytes through epigenetic regulation of p16INK4a
- Real-time in vivo imaging of p16INK4a reveals cross talk with p53
- Reappraisal Of The p16INK4a/Prb Pathway and Telomerase Activity, Markers Of Cell Activation and Aging, In Adult Acute Lymphoblastic Leukemia: A Graall Study
- Recovery of function in osteoarthritic chondrocytes induced by p16INK4a-specific siRNA in vitro
- Reduced c-Myc signaling triggers telomere-independent senescence by regulating Bmi-1 and p16INK4a
- Reduced levels of p15INK4b, p16INK4a, p21cip1 and p27kip1 in pancreatic carcinoma
- Reducing CDK4/6‐p16INK4a interface. Computational alanine scanning of a peptide bound to CDK6 protein
- Regulation effect of dihydroartemisinin on p16INK4a protein expression in human prostate cancer PC‐3 cells and its possible mechanism
- Regulation of CDK7–Carboxyl-Terminal Domain Kinase Activity by the Tumor Suppressor p16INK4a Contributes to Cell Cycle Regulation
- Regulation of cellular senescence and p16INK4a expression by Id1 and E47 proteins in human diploid fibroblast
- Regulation of cyclin D1 and p16INK4a is critical for growth arrest during mammary involution
- Regulation of p16INK4a and TGF-beta by DNA hydroxymethylation in glioblastoma multiforme
- Regulation of p16INK4a, The Cyclin Dependent Kinase Inhibitor & the Tumor Suppressor
- Regulatory Mechanisms of Tumor Suppressor p16INK4a and Their Relevance to Cancer
- RELATION OF THE PATTERN OF p16INK4a EXPRESSION TO THE GRADE OF CERVICAL INTRAEPITHELIA NEOPLASIA.
- Relationship among human papillomavirus infection, p16INK4a, p53 and NF-κB activation in penile cancer from northern Thailand
- Relationship between alterations of p16INK4a and p14ARF genes of CDKN2A locus and gastric carcinogenesis
- Relationship between epidermal growth factor receptor status, p16INK4a, and outcome in head and neck squamous cell carcinoma
- Relationship between expression and methylation status of p16INK4a and the proliferative activity of different areas’ tumour cells in human colorectal cancer
- Reproducibility of p16INK4a Biomarker Levels, as Measured by ELISA, Among HIV-Positive Women in Western Kenya With Normal Cervical Exams During a 12 …
- Requirements for cell cycle arrest by p16INK4a
- Resistance of primary cultured mouse hepatic tumor cells to cellular senescence despite expression of p16INK4a, p19Arf, p53, and p21Waf1/Cip1
- Response to the methylation inhibitor dihydro-5-azacytidine in mesothelioma is not associated with methylation of p16INK4a: results of cancer and leukemia …
- Response: Re: Biologic and Biochemical Analyses of p16INK4a Mutations From Primary Tumors
- Retinoic acid extends the in vitro life span of normal human oral keratinocytes by decreasing p16INK4a expression and maintaining telomerase activity
- Retroviral transfer of the p16INK4a cDNA inhibits C6 glioma formation in Wistar rats
- Retrovirus-mediated p16INK4a gene therapy for human hepatocellular carcinoma
- Reversal of hypermethylation and reactivation of p16INK4a, RARβ, and MGMT genes by genistein and other isoflavones from soy
- Reversible cell cycle inhibition and premature aging features imposed by conditional expression of p16INK4a
- Role and epigenetic regulation of p16INK4a-MMP-1 axis in OA-associated senescence-like phenotype and hypertrophy of chondrocytes
- Role for p16INK4a in progression of gastrointestinal stromal tumors of the stomach: alteration of p16INK4a network members
- Role of HPV-16 in pathogenesis of oral epithelial dysplasia and oral squamous cell carcinoma and correlation of p16INK4a expression in HPV-16 positive cases …
- Role of HSP90, CDC37, and CRM1 as modulators of p16INK4a activity in rat liver carcinogenesis and human liver cancer
- Role of p16INK4a and BMI-1 in oxidative stress-induced premature senescence in human dental pulp stem cells
- Role of p16INK4a as a biomarker in liquid-based cervical cytology screening
- Role of p16INK4a Cytology Testing as an Adjunct to Enhance the Diagnostic Specificity and Accuracy in Human Papillomavirus-Positive Women within an Organized …
- Role of p16INK4a in the inhibition of DNA synthesis stimulated by HGF or EGF in primary cultured rat hepatocytes
- ROLE OF p16INK4a, hTERT AND K-ras IN EARLY DETECTION OF GYNECOLOGICAL MALIGNANCIES
- Role of quantitative p16INK4a mRNA assay and digital reading of p16INK4a immunostained sections in diagnosis of cervical intraepithelial neoplasia
- Role of senescence marker p16INK4a measured in peripheral blood T-lymphocytes in predicting length of hospital stay after coronary artery bypass surgery in older …
- Role of the alternative INK4A proteins in human keratinocyte senescence: evidence for the specific inactivation of p16INK4a upon immortalization
- Roles of p15Ink4b and p16INK4a in myeloid differentiation and RUNX1-ETO-associated acute myeloid leukemia
- S-phase lengthening induced by p16INK4a overexpression in malignant cells with wild-type pRb and p53
- Screening for Human Papillomavirus in Basaloid Squamous Carcinoma: Utility of p16INK4a, CISH, and PCR
- Selective loss of resistant alleles at p15INK4B and p16INK4a genes in chemically-induced rat tongue cancers
- Senescence delay of human diploid fibroblast induced by anti-sense p16INK4a expression
- Sexual behaviour, HPV status and p16INK4a expression in oropharyngeal and oral cavity squamous cell carcinomas: a case–case comparison study
- Shelterin dysfunction and p16INK4a-mediated growth inhibition in HIV-1-specific CD8 T cells
- Shortening of human cell life span by induction of p16INK4a through the platelet‐derived growth factor receptor β
- Significance of immunohistochemical expression of p16INK4a in the differentiation of inflammatory and preneoplastic cervical lesions
- Significance of p16INK4a hypermethylation gene in primary head/neck and colorectal tumors: it is a specific tissue event? Results of a 3-year GOIM (Gruppo …
- Significance of the expression of EMMPRIN, CD24 and p16INK4a promoter methylation in gastric carcinoma
- Significant role for p16INK4a in p53-independent telomere-directed senescence
- Simulation of Different Truncated p16INK4a Forms and In Silico Study of Interaction with Cdk4
- Single-Center Analysis of Human Papillomavirus Infection and p16INK4a Expression among Korean Patients with Penile Cancer
- Single‐cell analysis of p16INK4a and p21WAF1 expression suggests distinct mechanisms of senescence in normal human and Li‐Fraumeni Syndrome fibroblasts
- SM22α-induced activation of p16INK4a/retinoblastoma pathway promotes cellular senescence caused by a subclinical dose of γ-radiation and doxorubicin in HepG2 …
- Specific allelic loss of p16INK4a tumor suppressor gene after weeks of iron-mediated oxidative damage during rat renal carcinogenesis
- Stabilization of Cyclin-Dependent Kinase 4 by Methionyl-tRNA Synthetase in p16INK4a-Negative Cancer
- Staining characteristics of p16INK4a: Is there a correlation with lesion grade or high‐risk human papilloma virus positivity?
- Stathmin 1 and p16INK4a are sensitive adjunct biomarkers for serous tubal intraepithelial carcinoma
- Status of p16INK4a and E-Cadherin Gene Promoter Methylation in Moroccan Patients With Cervical Carcinoma
- Staying Young with p16INK4a
- Stress-Induced Premature Senescence Promotes Proliferation by Activating the SENEX and p16INK4a/Retinoblastoma (Rb) Pathway in Diffuse Large B-Cell …
- Structural Analysis of the Inhibition of Cdk4 and Cdk6 by p16INK4a through Molecular Dynamics Simulations
- Structural Consequences of Tumor-Derived Mutations in p16INK4a Probed by Limited Proteolysis
- Structure and function of mouse p16INK4a locus
- Studies on the Expression of p16INK4a mRNA in Cervical Dysplasias
- Study of p16INK4a expression in cervical intraepithelial lesions and cervi-cal carcinoma
- STUDY OF REST AS A NEGATIVE REGULATOR OF p16INK4a
- Subcellular re-distribution of F-actin in MCF7 cells upon inducible expression of CDKN2A/p16INK4a
- Supplemental Data Significant Role for p16INK4a in p53-Independent Telomere-Directed Senescence
- Supplemental Data Telomere Shortening Triggers Senescence of Human Cells through a Pathway Involving ATM, p53, and p21CIP1, but Not p16INK4a
- Suppressing p16INK4a and P14ARF pathways overcomes apoptosis in individualized human embryonic stem cells
- SUPPRESSION OF ARTHRITIS BY ADENOVIRAL VECTOR MEDIATED p16INK4a GENE TRANSFER
- Survey of p16INK4a immunohistochemistry in diagnosis of dysplastic changes in cervix
- Sustained p16INK4a expression is required to protect against IR-induced lymphoma in mice
- Systemic clearance of p16INK4a‐positive senescent cells mitigates age‐associated intervertebral disc degeneration
- Systemic transduction of p16INK4a antitumor peptide inhibits lung metastasis of the MBT‑2 bladder tumor cell line in mice
- Systemic transduction of p16INK4a antitumor peptide inhibits the growth of MBT-2 mouse bladder tumor cell line grafts
- T-Cell p16INK4a Expression Increases Post-Transplant in Patients with Multiple Myeloma
- Targeted inactivation of HDAC2 restores p16INK4a activity and exerts antitumor effects on human gastric cancer
- Targeting p16INK4a in uterine serous carcinoma through inhibition of histone demethylation
- Telomerase Induces Immortalization of Human Esophageal Keratinocytes Without p16INK4a Inactivation1 1 NIH grants R01-DK5337 (AKR), P01-DE12467 (AKR) …
- Telomere dysfunction and inactivation of the p16INK4a/Rb pathway in pyothorax‐associated lymphoma
- Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21CIP1, but not p16INK4a
- Telomere-driven karyotypic complexity concurs with p16INK4a inactivation in TP53-competent immortal endothelial cells
- Tenofovir/emtricitabine metabolites and endogenous nucleotide exposures are associated with p16INK4a expression in subjects on combination therapy
- The 5′-flanking region of the E1 α form of the murine p16INK4a (MTS1) gene
- The 5′-untranslated region of p16INK4a melanoma tumor suppressor acts as a cellular IRES, controlling mRNA translation under hypoxia through YBX1 …
- The absence of high-risk HPV combined with specific p53 and p16INK4a expression patterns points to the HPV-independent pathway as the causative agent for …
- The acetylation of transcription factor HBP1 by p300/CBP enhances p16INK4a expression
- The association of increased p14ARF/p16INK4a and p15INK4a gene expression with proliferative activity and the clinical course of multiple myeloma
- The atr protein kinase controls UV-dependent upregulation of p16INK4a through inhibition of Skp2-related polyubiquitination/degradation
- The basic helix–loop–helix transcription factor TAL1/SCL inhibits the expression of the p16INK4a and pTα genes
- The Battle between Tumor Suppressors: Is Gene Therapy Using p16INK4a More Efficacious Than p53 for Treatment of Ovarian Carcinoma?: Commentary re: SC …
- The Bmi-1 oncoprotein is overexpressed in human colorectal cancer and correlates with the reduced p16INK4a/p14ARF proteins
- The cell cycle inhibitor p16INK4a sensitizes lymphoblastic leukemia cells to apoptosis by physiologic glucocorticoid levels
- The Cell Cycle Regulators p16INK4a, P15INK4b and Cyclin D1: Relationship to Clinicopathological Parameters and Disease-free Survival in Laryngeal Carcinoma …
- The clinical impact of using p16INK4a immunochemistry in cervical histopathology and cytology: An update of recent developments
- The co-transfection of p16INK4a and p14ARF genes into human lung cancer cell line A549 and the effects on cell growth and chemosensitivity
- The contrasting role of p16INK4a patterns of expression in neuroendocrine and non-neuroendocrine lung tumors: a comprehensive analysis with …
- The COOH terminus of p18INK4C distinguishes function from p16INK4a
- The cyclin-dependent kinase inhibitor p16INK4a physically interacts with transcription factor Sp1 and cyclin-dependent kinase 4 to transactivate microRNA-141 and …
- The effect of acute dichlorodiphenyltrichloroethane exposure on hypermethylation status and down‐regulation of p53 and p16INK4a genes in rat liver
- The effects of chronic and acute toxicological exposures on the expression of the tumor suppressor p16INK4a
- The effects of fucodian on senescence are controlled by the p16INK4a-pRb and p14Arf-p53 pathways in hepatocellular carcinoma and hepatic cell lines
- The effects of short-term hypoxia on human mesenchymal stem cell proliferation, viability and p16INK4a mRNA expression: Investigation using a simple …
- The effects of transferring tumor suppressor gene p16INK4a to p16INK4a-deleted cancer cells
- The evaluation of p16INK4a immunoexpression/immunostaining and human papillomavirus DNA test in cervical liquid-based cytological samples
- The expression and significance of insulin like growth factor-II mRNA binding protein 3 (IMP3) and p16INK4a in adenocarcinoma of the uterine cervix
- The expression and significance of PCNA, CDK4 and p16INK4a in nonneoplastic epithelial disorders of vulvar
- The Expression of E6 HPV, P53 nd p16INK4a at Well, Moderately, and Poorly Differentiated Cervical Adenocarcinoma
- THE EXPRESSION OF p16INK4a IN ODONTOGENIC CYSTS AND TUMORS
- The expression of p16INK4a tumor suppressor is upregulated by human cytomegalovirus infection and required for optimal viral replication
- The expression of p16INK4a, the product of a tumor suppressor gene for melanoma, is upregulated in human melanocytes by UVB irradiation
- The expression of Topoisomerase Ⅱ and p16INK4a in cervical intraepithelial neoplasia after infection of high-risk type human papillomavirus and their value for …
- The Expressions of Cell Cycle Regulatory Proteins p14arf, p16INK4a and p53 in Human Endometrial Carcinoma [J]
- The homeoprotein SIX1 controls cellular senescence through the regulation of p16INK4a and differentiation-related genes
- The human p19ARF protein encoded by the β transcript of the p16INK4a gene is frequently lost in small cell lung cancer
- The induction of H3K9 methylation by PIWIL4 at the p16INK4a locus
- The influence of anthracosis and p16INK4a gene aberrant methylation on small-sized pulmonary adenocarcinoma
- The Influence of PDL 585 nm Laser on the Expression of p16INK4a of Human Fibroblast in Vitro [J]
- The inherent instability of mutant p53 is alleviated by Mdm2 or p16INK4a loss
- The inhibition of T-cells proliferation by mouse mesenchymal stem cells through the induction of p16INK4a-cyclin D1/cdk4 and p21waf1, p27kip1-cyclin E/cdk2 …
- The inhibitor of cyclin-dependent kinase 4a/alternative reading frame (INK4a/ARF) locus encoded proteins p16INK4a and p19ARF repress cyclin D1 transcription …
- The inhibitory effect of adenovirus-mediated p16INK4a gene transfer on the proliferation of lung cancer cell line.
- The invasion front of human colorectal adenocarcinomas shows co-localization of nuclear β-catenin, cyclin D1, and p16INK4a and is a region of low proliferation
- The loss of p16INK4a function is essential for Werner Syndrome mouse embryo fibroblasts to escape from senescence
- The lymphoma-associated NPM-ALK oncogene elicits a p16INK4a/pRb-dependent tumor-suppressive pathway
- The meaning of p16INK4a expression in tumors: Functional significance, clinical associations and future developments
- The melanoma‐associated 24 base pair duplication in p16INK4a is functionally impaired
- The methylation pattern of p16INK4a gene promoter in psoriatic epidermis and its clinical significance
- The methylation profile of p16INK4a in alt tumor cells derived from werner syndrome mouse model
- The methylation status and protein expression of CDH1, p16INK4a, and fragile histidine triad in nonsmall cell lung carcinoma: Epigenetic silencing, clinical features …
- The methylthioadenosine phosphorylase gene is frequently co‐deleted with the p16INK4a gene in acute type adult T‐cell leukemia
- The molecular balancing act of p16INK4a in cancer and aging
- The negative predictive value of p16INK4a to assess the outcome of cervical intraepithelial neoplasia 1 in the uterine cervix
- The number of p16INK4a positive cells in human skin reflects biological age
- The OGF–OGFr Axis Utilizes the p16INK4a and p21WAF1/CIP1 Pathways to Restrict Normal Cell Proliferation
- The overexpression of histone deacetylase 1 and its relationship with p16INK4a gene hypermethylation in pulmonary squamous cell carcinoma and …
- The p15INK4b/p16INK4a/RB1 Pathway Is Frequently Deregulated in Human Pituitary Adenomas
- The p16INK4a Expression in Stomach Cancer, Colon Cancer and Hepatoma Cell Lines
- The p16INK4a mRNA transcripts estimation in cervical smear with different degrees of cervical dysplasia
- The p16INK4a protein: a cytological marker for detecting high grade intraepithelial neoplasia of the uterine cervix
- The p16INK4a tumor suppressor regulates cellular oxidative stress
- The p16INK4a tumour suppressor protein inhibits αvβ3 integrin‐mediated cell spreading on vitronectin by blocking PKC‐dependent localization of αvβ3 to focal …
- The p16INK4a-RB pathway: molecular link between cellular senescence and tumor suppression
- The p16INK4a/pRb pathway and telomerase activity define a subgroup of Ph+ adult Acute Lymphoblastic Leukemia associated with inferior outcome
- The PAX3-FKHR fusion gene of rhabdomyosarcoma cooperates with loss of p16INK4a to promote bypass of cellular senescence
- The PPARα/p16INK4a Pathway Inhibits Vascular Smooth Muscle Cell Proliferation by Repressing Cell Cycle–Dependent Telomerase Activation
- The Predictive Value of p16INK4a and Hybrid Capture 2 Human Papillomavirus Testing for High-Grade Cervical Intraepithelial Neoplasia
- The predictive value of p16INK4a immunocytochemistry as an adjunctive test for borderline cervical cytology
- The presence of high‐risk HPV combined with specific p53 and p16INK4a expression patterns points to high‐risk HPV as the main causative agent for …
- The presence of methylation of the p16INK4a gene and human papillomavirus in high-grade cervical squamous intraepithelial lesions
- The prevalence and clinicopathologic correlate of p16INK4a, retinoblastoma and p53 immunoreactivity in locally advanced urinary bladder cancer
- The prognostic significance of p16INK4a/p14ARF and p15INK4b deletions in adult acute lymphoblastic leukemia
- The prognostic significance of p16INK4a/p14ARF locus deletion and MDM‐2 protein expression in adult acute myelogenous leukemia
- The reduced expression and aberrant methylation of p16INK4a in chromate workers with lung cancer
- The retinoblastoma protein/p16INK4a pathway but not p53 is disrupted by human papillomavirus in penile squamous cell carcinoma
- The role and regulation of tumor suppressor p16INK4a in intestinal neoplasia
- The role of biomarkers (p16INK4a and Ki-67) in cervical cancer screening: An appraisal
- The role of deeper levels and ancillary studies (p16INK4a and ProExC) in reducing the discordance rate of Papanicolaou findings of high‐grade squamous …
- The Role of p16INK4a Expression in the Age-related Risk of Venous Thromboembolism
- The role of p16INK4a pathway in human epidermal stem cell self-renewal, aging and cancer
- The role of polyhomeotic in polycomb group-mediated regulation of the tumour suppressor p16INK4a
- The rs11515 polymorphism is more frequent and associated with aggressive breast tumors with increased ANRIL and decreased p16INK4a expression
- The Sensitivity and Specificity of p16INK4a Cytology vs HPV Testing for Detecting High-Grade Cervical Disease in the Triage of ASC-US and LSIL Pap Cytology …
- The significance of liquid-based cytology test in combination with p16INK4a and cyclin E in diagnosis of cervical intraepithelial neoplasia.
- The significance of p16INK4a in cell defences against transformation
- The Significance of p16INK4a protein Expression in the Cervical Cancer
- The specific role of pRb in p16INK4a-mediated arrest of normal and malignant human breast cells
- The specificity and patterns of staining in human cells and tissues of p16INK4a antibodies demonstrate variant antigen binding
- The study of CDKN2/p16INK4a mutation in human breast cancer
- The thymine DNA glycosylase MBD4 represses transcription and is associated with methylated p16INK4a and hMLH1 genes
- The triage of low-grade cytological abnormalities by the immunocytological expression of cyclin-dependent kinase inhibitor p16INK4a versus Human Papillomavirus …
- The tumor suppressor p33ING1b upregulates p16INK4a expression and induces cellular senescence
- The tumor suppressor protein p16INK4a
- The Tumor Suppressor Protein p16INK4a and the Human Papillomavirus Oncoprotein-58 E7 Are Naturally Occurring Lysine-less Proteins That Are Degraded by the …
- The tumour suppressor CDKN2A/p16INK4a regulates adipogenesis and bone marrow-dependent development of perivascular adipose tissue
- The use of p16INK4a as an adjunct to the interpretation of cervical biopsies
- The use of p16INK4a immunocytochemistry in “Atypical squamous cells which cannot exclude HSIL” compared with “Atypical squamous cells of undetermined …
- The use of p16INK4a in further defining atypical squamous cells cannot exclude a high grade lesion on cervical cytology (ASC-H): results of a pilot study
- The use of recombinant pseudotype virus-like particles harbouring inserted target antigen to generate antibodies against cellular marker p16INK4a
- The usefulness of p16INK4a in cytological screening of cervical carcinoma
- The utility of p16INK4a and Ki-67 as a conjunctive tool in uterine cervical lesions
- The utility of p16INK4a and Ki‐67 staining on cell blocks prepared from residual thin‐layer cervicovaginal material
- The utility of p16INK4a expression in uterine cervical biopsies reported negative and positive for dysplasia at Kenyatta National Hospital, Nairobi, Kenya
- The Utility of p16INK4a in Discriminating Between Cervical Intraepithelial Neoplasia 1 and Nonneoplastic Equivocal Lesions of the Cervix
- The utility of ThinPrep cytology and immunohistochemical staining of p16INK4a, Ki-67, and p63 in the assessment of cervical intraepithelial neoplasia (dysplasia)
- The value of p16INK4a expression by fluorescence in situ hybridization in triage for high risk HPV positive in cervical cancer screening
- Thin HSIL of the cervix: detecting a variant of high-grade squamous intraepithelial lesions with a p16INK4a antibody
- Three-tiered score for Ki-67 and p16INK4a improves accuracy and reproducibility of grading CIN lesions
- TMEM45A, SERPINB5 and p16INK4a transcript levels are predictive for development of high-grade cervical lesions
- TP53 and p16INK4a mutations in adult-T cell leukemia/lymphoma (ATL) in Bahia (Brazil)
- TP53 and p16INK4a, but not H‐KI‐Ras, are involved in tumorigenesis and progression of pleomorphic adenomas
- TP53, p14ARF, p16INK4a and H‐ras gene molecular analysis in intestinal‐type adenocarcinoma of the nasal cavity and paranasal sinuses
- Transcriptional regulation of the CDK inhibitor p16INK4a gene by a novel pRb‐associated repressor, RBAR1
- Transduced p16INK4a peptides inhibit hypophosphorylation of the retinoblastoma protein and cell cycle progression prior to activation of Cdk2 complexes in late G1
- Transgenic expression of the p16INK4a cyclin-dependent kinase inhibitor leads to enhanced apoptosis and differentiation arrest of CD4− CD8− immature thymocytes
- Transient induction of the p16INK4a/pRb pathway leads to stable changes in telomerase in normal and malignant breast epithelial cells
- Transition of cervical carcinoma in situ to invasive cancer: Role of p16INK4a expression in progression and in recurrence
- Transoral robotic surgery and adjuvant therapy for oropharyngeal carcinomas and the influence of p16INK4a on treatment outcomes
- Triage of women with ASCUS and LSIL cytology Use of qualitative assessment of p16INK4a positive cells to identify patients with high‐grade cervical intraepithelial …
- TSG101 promotes SUMOylation of HDAC1 that represses p16INK4a expression
- TUMOR SUPPRESSING FUNCTIONS OF p16INK4a-A REVIEW
- Tumor Suppression for ARFicionados: The Relative Contributions of p16INK4a and p14ARF in Melanoma
- Tumor suppressor and aging biomarker p16INK4a induces cellular senescence without the associated inflammatory secretory phenotype
- Tumor suppressor INK4: Comparisons of conformational properties between p16INK4a and p18INK4C
- Tumor suppressor INK4: determination of the solution structure of p18INK4C and demonstration of the functional significance of loops in p18INK4C and p16INK4a
- Tumor suppressor p16INK4a − modulator of glycomic profile and galectin‐1 expression to increase susceptibility to carbohydrate‐dependent induction of anoikis in …
- Tumor suppressor p16INK4a controls oncogenic K‐Ras function in human pancreatic cancer cells
- Tumor suppressor p16INK4a determines sensitivity of human cells to transformation by cooperating cellular oncogenes
- Tumor suppressor p16INK4a inhibits cancer cell growth by downregulating eEF1A2 through a direct interaction
- Tumor suppressor p16INK4a is necessary for survival of cervical carcinoma cell lines
- Tumor suppressor p16INK4a regulates polycomb-mediated DNA hypermethylation in human mammary epithelial cells
- Tumor suppressor p16INK4a regulates polycomb-mediated DNA hypermethylation in human mammary epithelial cells.
- Tumor Suppressor p16INK4a: Structural Characterization of Wild-Type and Mutant Proteins by NMR and Circular Dichroism
- Tumor suppressor p16INK4a: determination of solution structure and analyses of its interaction with cyclin-dependent kinase 4
- Tumor suppressor p16INK4a: Downregulation of galectin‐3, an endogenous competitor of the pro‐anoikis effector galectin‐1, in a pancreatic carcinoma model
- Tumor suppressor p16INK4a/Cdkn2a alterations in 7, 12‐dimethylbenz(a)anthracene (DMBA)‐induced hamster cheek pouch tumors
- Tumour suppressor p16INK4a – anoikis‐favouring decrease in N/O‐glycan/cell surface sialylation by down‐regulation of enzymes in sialic acid biosynthesis in …
- Two mechanisms underlying the loss of p16INK4a function are associated with distinct tumorigenic consequences for WS MEFs escaping from senescence
- Ultrasensitive electrochemical immunosensor based on dual signal amplification process for p16INK4a cervical cancer detection in clinical samples
- Understanding the Early Events in Breast Carcinogenesis by Inactivating p16INK4a in Primary Human Mammary Epithelial Cells
- Unfolding transition state and intermediates of the tumor suppressor p16INK4a investigated by molecular dynamics simulations
- Up-regulated expression of E2F2 is necessary for p16INK4a-induced cartilage injury
- Up-regulation of p27Kip1, p21WAF1/Cip1 and p16INK4a is associated with, but not sufficient for, induction of squamous differentiation
- Up-regulation of survivin during immortalization of human myofibroblasts is linked to repression of tumor suppressor p16INK4a protein and confers resistance to …
- Upregulation of Anti-Oxidant Signal Pathway and Cytokine Release by Inhibition of p16INK4a in Aging Human Cardiac Progenitor Cells
- Upregulation of p16INK4a promotes cellular senescence of bone marrow-derived mesenchymal stem cells from systemic lupus erythematosus patients
- Upregulation of survivin during immortalization is linked to repression of p16INK4a and confers resistance to oxidative stress
- Uropathogenic E. coli infection provokes epigenetic downregulation of CDKN2A (p16INK4a) in uroepithelial cells
- Use of Cytology, E6/E7 mRNA, and p16INK4a–Ki-67 to Define the Management of Human Papillomavirus (HPV)–Positive Women in Cervical Cancer Screening
- Usefulness of CINtec® PLUS p16INK4a/Ki-67 double-staining in cytological screening of cervical cancer
- Utility of p16INK4a Immunocytochemistry in Liquid-Based Cytology Specimens from Women Treated for High-Grade Squamous Intraepithelial Lesions
- Utility of p16INK4a, CEA, Ki67, P53 and ER/PR in the differential diagnosis of benign, premalignant, and malignant glandular lesions of the uterine cervix and their …
- V600EBraf induces gastrointestinal crypt senescence and promotes tumour progression through enhanced CpG methylation of p16INK4a
- Validation of p16INK4a as a marker of oncogenic human papillomavirus infection in cervical biopsies from a population-based cohort in Costa Rica
- Valproic acid induces apoptosis, p16INK4a upregulation and sensitization to chemotherapy in human melanoma cells
- Value of p16INK4a and RASSF1A promoter hypermethylation in prognosis of patients with resectable non–small cell lung cancer
- Value of p16INK4a as a marker of progression/regression in cervical intraepithelial neoplasia grade 1
- Value of p16INK4a in the diagnosis of low‐grade urothelial carcinoma of the urinary bladder in urinary cytology
- Value of p16INK4a in the pathology of invasive penile squamous cell carcinomas: a report of 202 cases
- VentX trans-activates p53 and p16INK4a to regulate cellular senescence
- Which test is a better strategy to determine the outcome of atypical glandular cell-categorized Pap smears? Immunocytochemical p16INK4a expression or human …
- Widespread cell cycle inhibition and features of premature aging in mice with conditional expression of p16INK4a
- Wild type and melanoma-associated mutant p16INK4a proteins do not oligomerize in vivo
- Wild-type p16INK4a suppresses cell growth, telomerase activity and DNA repair in human breast cancer MCF-7 cells
- WRAP53β, survivin and p16INK4a expression as potential predictors of radiotherapy/chemoradiotherapy response in T2N0-T3N0 glottic laryngeal cancer
- Značaj imunohistohemijske ekspresije p16INK4a u razlikovanju inflamacijskih i preneoplastičnih lezija grlića materice
- α-Mangostin induces G1 cell cycle arrest in HCT116 cells through p38MAPK-p16INK4a pathway
- β-Catenin induces immortalization of melanocytes by suppressing p16INK4a expression and cooperates with N-Ras in melanoma development
