DRY FASTING: THE ULTIMATE PATH TO LONGEVITY
A TRUE LIFE OR DEATH SCENARIO
On extended dry fasts the first few days are the roughest as the body is still optimistically holding out for food or water but once it figures out that water and food are not coming and that death is imminent if it doesn’t adapt and fast to given circumstance it switches gears into survival mode— this highly adapted state IS the magical key of dry fasting. Survival of the fittest. All weakness is eradicated. The option of supporting the diseased and parasitic is no longer viable. All non essentials are eliminated and recycled to sustain the essentials. This IS cellular renewal at the deepest level— unattainable by any other means.
A 5 DAY DRY FAST SCIENTIFIC STUDY:
While indeed longer duration dry fasts, 3 to 7 days and beyond, are best utilized to bring an ill or obese person back into balance—once homeostasis is restored daily dry fasting is the most effective disease preventive measure one can employ in maintaining optimal health and delaying aging.
This is the how and why behind dry fasting.
DAILY DRY FASTING in conjunction with anti-aging herbs and diet— the SCIENCE behind it.
For daily dry fasting which is your wisest protocol for maintaining a precision tuned body built for the long haul a 1-6 hour eating window is recommended with your highest level of activity including workout around this time as well.
In other words:
23:1, 22:2, 21:3, 20:4, 19:5 or 18:6
1st number dry, 2nd number feeding window.
RESTRICTION OF FEEDING TIME —WHY?
**It’s not what you eat so much as WHEN you eat. **
“Feeding schedule has been shown to have a signifiant impact on health and survival. In studies, time-restricted feeding had profound effects on neural, peripheral, and cardiovascular physiology and improved sleep, body weight maintenance, and delayed signs of cardiac aging, under UNCHANGED caloric intake and activity.”
There are 3 factors we are focusing on that promotes longevity and absence of disease:
All 3 are activated by KETOSIS* which is a rapid result of DRY FASTING. (No water or food.)
*KETONE BODIES STIMULATE CHAPERONE-MEDIATED AUTOPHAGY
“Interestingly, the increase in the concentration of circulating ketone bodies parallels the induction of CHAPERONE-MEDIATED AUTOPHAGY (CMA), which is also activated by prolonged starvation.
In these studies we have demonstrated that ketone bodies, more specifically BOH, stimulate CMA by causing the oxidation of substrates. In addition, during prolonged starvation CMA is activated because of increased lamp2a in the lysosomal membrane and increased lyhsc70 in the lysosomal lumen (9, 31). Our data indicate that ketone bodies can also stimulate CMA by affecting substrate proteins during prolonged starvation in vivo. This finding gives us further insight into the physiological importance of CMA stimulation during times of nutrient deprivation.”
Chaperone-mediated autophagy: roles in disease and aging http://www.nature.com/cr/journal/v24/n1/pdf/cr2013153a.pdf
To understand autophagy you need to understand lysosomes. Watch this brief video explaining what they are.
EXCELLENT VIDEO visually explaining the 3 types of AUTOPHAGY:
3. Chaperone-Mediated Autophagy
WHY NO WATER?
The ketogenic diet (KD) is traditionally introduced with an initial period of fasting and fluid restriction. *Since the 1930s it has been known that fluid restricted fasting accelerates ketosis which in turn has positive effects on preventing epilepsy.
IMPORTANT: Over-hydrate 1-2 gallons of water a day for 3-7 days to downregulate aldosterone before beginning. Once you pull back on the water on your dry fast the fat will fall right off you. Read: https://scholar.google.com/scholar…
Question: If dehydration RAISES blood sugar and fasting LOWERS blood sugar —what happens when you combine them together as in dry fasting?
ULTRA RAPID ONSET OF KETOSIS!
“Fasting resulted in reduced plasma glucose concentrations compared with the control study, while dehydration resulted in increased plasma glucose concentrations compared with the control study (P < .001). Glucose production and disposal were decreased during the fasting study and increased during the dehydration study compared with the control study.
***Glucagon concentrations and rates of development of ketosis and metabolic acidosis were increased during both fasting and dehydration compared with control.***
These data suggest that fasting and dehydration have differential effects on glycemia during insulin deficiency, with dehydration favoring the development of hyperglycemia and fasting resulting in reduced glucose concentrations.”
Here’s the numbers:
Dry fasting = Ketosis in 12-24 hours
Water fasting = Ketosis in 48-72 hours.
Test it and see for yourself.
Get ketostix: http://www.theketogenicdiet.org/ketostix/
What is Glucagon?
Glucagon is a peptide hormone, produced by alpha cells of the pancreas. It works to raise the concentration of glucose in the bloodstream. Its effect is opposite that of insulin, which lowers the glucose.
Why is KETOSIS important and what is it’s link to autophagy, mTOR inhibition, AMPK activation?
Calorie restriction and its effects on aging:
All about mTOR: http://selfhacked.com/…/11/03/mtor-natural-mtor-inhibitors/…
DRY FASTING (DEHYDRATION) INHIBITS MTOR
Direct inactivation of mTOR, stimulation of the AMP-activated protein kinase, and the destabilization of individual proteins may impair mTOR signaling under dehydrating conditions.
What Is AMPK?
“AMPK stands for adenosine monophosphate-activated protein kinase. It is found in every living cell of every living mammal (and most other animals) on Earth. If you want to avoid the life span-shortening symptoms of aging, you need to maintain optimal AMPK activity.
AMPK has been referred to as a “metabolic master switch.” AMPK controls a gamut of metabolic pathways that enable us to extract energy from food, store and distribute that energy safely through the body, and ultimately use that energy for everything from moving and mating to talking and thinking, and even to understanding these very words as you read them.
The core role of AMPK is to sense each cell’s energy status at every moment, and to trigger responses that maintain the cell’s energy at precisely the optimum level. Too little available energy starves the cell, while too much energy can exhaust and disrupt cellular components.In either case (too little or too much energy), the cell (and the tissues, organs, and systems in which it is a part) functions inefficiently. That energy inefficiency ultimately leads to the dysfunctions we identify as the diseases (or symptoms) of aging.
Here’s how AMPK works: Every cell in your body depends absolutely on a steady supply of energy in the form of chemical bonds. When you eat and absorb nutrients, energy from chemical bonds in food is released and passed down a complex series of enzymes until it is stored again in a molecule called adenosine triphosphate, or ATP. The more ATP that is present in the cell, the higher the cell’s available energy supply. When ATP is broken down to release energy for cellular work, a major end product is adenosine monophosphate, or AMP.
In preclinical research, enhanced AMPK activity has been associated with a 20-30% increase in life span, but that’s just the beginning of the health benefits conferred by this critical cellular enzyme.
Increased AMPK activation has been shown to help reduce fat storage (especially dangerous belly fat), increase insulin sensitivity (to lower blood glucose), reducecholesterol/triglyceride production, and suppress chronic inflammation. All of these factors underlie the lethal diseases of aging.”
Autophagy is the best Way to Get Rid of (Cellular) Junk. READ: http://www.anti-agingfirewalls.com/…/autophagy-the-houseke…/
How AUTOPHAGY regulates AGING:
“The accumulation of cellular damage is a feature common to all aging cells and leads to decreased ability of the organism to survive. The overall rate at which damage accumulates is influenced by conserved metabolic factors (longevity pathways and regulatory proteins) that control lifespan through adjusting mechanisms for maintenance and repair. Autophagy, the major catabolic process of eukaryotic cells that degrades and recycles damaged macromolecules and organelles, is implicated in aging and in the incidence of diverse age-related pathologies. Recent evidence has revealed that autophagic activity is required for lifespan extension in various long-lived mutant organisms, and that numerous autophagy-related genes or proteins are directly regulated by longevity pathways. These findings support the emerging view that autophagy is a central regulatory mechanism for aging in diverse eukaryotic species.”
AMPK and autophagy also are activated by intense exercise. More here: https://scholar.google.com/scholar…
Exercise ENHANCES rather than inhibits mTOR and increases protein synthesis (muscle growth) so you want to time it near feeding window. More here: https://scholar.google.com/scholar…
Aging controlled by mTOR
“There is overwhelming evidence that cellular mechanisms and signaling pathways regulating ageing are controlled by mTOR. Here we have highlighted important studies that support a role for both mTOR dependent protein synthesis and autophagy in ageing.”
***WE DRY FAST TO INHIBIT MTOR***
The LESS you keep the MTOR pathway open or active the GREATER your health will be and the LONGER you will live.
Growth or longevity. One or the other.
Here’s your percentages of mTOR activation based on feeding and intense exercise window times:
6 hour window is 25%
5 hour window is 20%,
4 hour window is 16%,
3 hour window is 12%,
2 hour window is 8%,
1 hour window is 4%.
The smaller the window the better.
Don’t dilly dally when it’s open.
When the feeding window and MTOR pathway is OPEN it’s GO TIME. You go into the gym and WRECK SHOP, refuel and rehydrate then close the window and shut down mTOR again.
The type of exercise I recommend is of short duration and peak intensity. No lolly gagging! Hour or less. Legs one day; upper body next. Too much exercise is not good and prematurely wears the body out. Intense in and out. Cardio ideas: Sprints are wonderful. Swimming laps are great as well as stationary bike intervals 10 seconds (peak exertion) LEVEL 10 followed by 50 seconds (rest) LEVEL 1 for 15-20 cycles.
AMPK ACTIVATION AND INTENSE INTERVAL EXERCISE
“Brief intense interval exercise activates AMPK and p38 MAPK signaling and increases the expression of PGC-1 in human skeletal muscle
In summary, the present study showed that four 30-s bouts of all out cycling increased phosphorylation of AMPK 1, AMPK 2, and p38 MAPK immediately following exercise and the mRNA expression of PGC-1 after 3 h of recovery. Specific signaling through AMPK and p38 MAPK to PGC-1 may therefore explain in part the metabolic remodeling in- duced by intense interval exercise training, including mitochondrial biogenesis and an increased capacity for glucose and fatty acid oxidation.”
LEUCINE ACTIVATES mTOR and thus increases protein synthesis so it can be used to accelerate muscle growth AT BEGINNING of exercise window
FASTING AND CARDIO-PROTECTION
What’s that? To understand dry fasting (deliberate dehydration and starvation) is to understand hormesis.
“That which doesn’t kill you makes you stronger.” — Nietzsche
“All things are poison and nothing is without poison; only the dose makes a thing not a poison.” —Paracelsus
Even water and oxygen in excess can be deadly; as can their absence.
What we are doing is deliberately stressing the body— to make it more resilient.
“Hormesis is a biological phenomenon whereby a beneficial effect (improved health, stress tolerance, growth or longevity) results from exposure to low doses of an agent that is otherwise toxic or lethal when given at higher doses.”
Too much dry fasting can kill just as over eating or over drinking can kill.
We are in a sense flexing our cells “muscles”; making them extremely adaptable and tough.
“No water? No food? No problem. Wake me up when we got a real crisis on our hands.”
All about hormesis here: https://scholar.google.com/scholar…
***INSULIN BLOCKS SIRT1*** (not good)
SIRT1 stands for sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae), referring to the fact that its sirtuin homolog (biological equivalent across species) in yeast (S. cerevisiae) is Sir2. SIRT1 is an enzyme that deacetylates proteins that contribute to cellular regulation (reaction to stressors, longevity).
A major cause of aging is thought to result from the cumulative effects of cell loss over time. In yeast, caloric restriction (CR) delays aging by activating the Sir2 deacetylase. Here we show that expression of mammalian Sir2 (SIRT1) is induced in CR rats as well as in human cells that are treated with serum from these animals. Insulin and insulin-like growth factor 1 (IGF-1) attenuated this response. SIRT1 deacetylates the DNA repair factor Ku70, causing it to sequester the proapoptotic factor Bax away from mitochondria, thereby inhibiting stress-induced apoptotic cell death. Thus, CR could extend life-span by inducing SIRT1 expression and promoting the long-term survival of irreplaceable cells.
FASTING AND STEM CELL REGENERATION
• fasting downregulates a IGF-1/PKA pathway in stem cells
• Prolong fasting protects hematopoietic cells from chemotoxicity
• Prolonged fasting cycles promote HSC self-renewal to reverse immunosuppression
• Inhibition of IGF-1 or PKA signaling mimics the effects of prolonged fasting
Immune system defects are at the center of aging and a range of diseases. Here, we show that prolonged fasting reduces circulating IGF-1 levels and PKA activity in various cell populations, leading to signal transduction changes in long-term hematopoietic stem cells (LT-HSCs) and niche cells that promote stress resistance, self-renewal, and lineage-balanced regeneration. Multiple cycles of fasting abated the immunosuppression and mortality caused by chemotherapy and reversed age-dependent myeloid-bias in mice, in agreement with preliminary data on the protection of lymphocytes from chemotoxicity in fasting patients. The proregenerative effects of fasting on stem cells were recapitulated by deficiencies in either IGF-1 or PKA and blunted by exogenous IGF-1. These findings link the reduced levels of IGF-1 caused by fasting to PKA signaling and establish their crucial role in regulating hematopoietic stem cell protection, self-renewal, and regeneration.
METABOLIC TRIGGERS OF AUTOPHAGY
In isolated cells, autophagy is generally induced by limitations in ATP availability or a lack of essential nutrients, including glucose and amino acids (i.e. FASTING or KETOGENIC diet).
COLD THERMOGENESIS & MTOR
To withstand cold you MUST activate mTOR to maintain body temperature.
MTOR (ACTIVATION) IS REQUIRED FOR BROWN ADIPOSE TISSUE RECRUITMENT AND METABOLIC ADAPTATION TO COLD https://www.nature.com/articles/srep37223
MTOR (ACTIVATED) IS A KEY MODULATOR OF AGING AND AGE RELATED DISEASE
RAPAMYCIN BLOCKS INDUCTION OF THE THERMOGENIC PROGRAM IN WHITE ADIPOSE TISSUE
Here, we report that rapamycin blocks the ability of β-adrenergic signaling to induce beige adipocytes and expression of thermogenic genes in white adipose depots. Rapamycin enhanced transcriptional negative feedback on the β3-adrenergic receptor. However, thermogenic gene expression remained impaired even when the receptor was bypassed with a cell-permeable cAMP analog, revealing the existence of a second inhibitory mechanism. Accordingly, rapamycin-treated mice are cold intolerant, failing to maintain body temperature and weight when shifted to 4°C.
RAMADAN IS DAILY INTERMITTENT DRY FASTING —why not apply this wise practice every day and not just Ramadan?
“Fasting in the month of Ramadan is ordained on the Muslim believers. Ramadan fasting has not only been spiritually beneficial but it has physical, psychological, social and health benefits.
Ramadan is a month of self regulation, process of self purification, truthfulness and self trainings with the hope that this training will last beyond the end of Ramadan. One advantage of fasting is that the poor are given attention and benefits from charity and the faithful practice of the concept of neighbourhood and hospitality.
The physiological effect of fasting includes lowering of blood sugar, lowering of cholesterol and lowering of the systolic blood pressure. In fact, Ramadan fasting would be an ideal recommendation for treatment of mild to moderate, stable, non-insulin diabetes, obesity and essential hypertension. Fasting is powerful therapeutic processes that can help people recover from mild to severe health conditions. Our body has a self healing power, in order to activate this power, the stomach must be kept empty, if Ramadan fasting is done properly it can help to recover from most diseases.”
P53: THE ANTI-TUMOR GENE AND FASTING
What is P53?
P53, also known as TP53 or tumor protein (EC :184.108.40.206) is a gene that codes for a protein that regulates the cell cycle and hence functions as a tumor suppression. It is very important for cells in multicellular organisms to suppress cancer.
“Our findings that CR or a 1 day/week fast suppressed carcinogenesis—even when started late in life in mice predestined to develop tumors due to decreased p53 gene dosage—support efforts to identify suitable interventions influencing energy balance in humans as a tool for cancer prevention.”
Ghrelin the anti-aging hunger hormone is released about 12 hours after your last meal. This is why you want lots of Ghrelin:
But what about lack of water and kidneys?
“High fluid intake does not appear to slow renal disease progression in humans.”
PROTECT KIDNEYS by ALKALINIZING periodically before and after dry fasts with a simple teaspoon of BAKING SODA in water.
WHY YOU WANT TO TAKE BAKING SODA TO RAISE PH WHILE IN KETOSIS FOR MAXIMUM FAT LOSS
“An acidosis produced by feeding HCl is antiketogenic and an alkalosis resulting from NaHC03 (baking soda) administration is ketogenic in the fasting albino rat when ketosis is measured by the level of the ketone bodies in the blood as well as the degree of ketonuria. Acid administration causes an increase in the liver glycogen concentration and in the daily excretion of nitrogen and sulfur in the urine, while the alkalosis leads to a decrease from normal in all of these values. It is concluded from this that the antiketogenic effect of acidosis depends upon an increase in protein catabolism and an increase in glucose formation therefrom, while alkalosis is ketogenic because it has an opposite effect upon this process.”
We want MORE ketosis (fat burning) not less!
IMPORTANT: Once your ph drops you are eating muscle.
*First attain deep level ketosis from dry fasting then add baking soda; strive to keep urine around 7.5ph while simultaneously maintaining deep level ketosis (80-160).
“Oral Hydration and Alkalinization is Noninferior to Intravenous Therapy for Prevention of Contrast-Induced Nephropathy in Patients with Chronic Kidney Disease”
More on WHY YOU WANT TO BE ALKALINE while in KETOSIS. Acidic ph inhibits autophagy; alkaline stimulates it.
“In this study, we show that in rat cardiomyocytes, acidic extracellular pH (pHe) inhibits autophagy, whereas alkaline pHe stimulates it. We also find that adenosine monophosphate-activated protein kinase (AMPK), mammalian target of rapamycin (mTOR) and Unc-51-like kinase 1 (ULK1) are very sensitive to pHe changes. Furthermore, by interfering with AMPK, mTOR or ULK1 activity, we demonstrate that the AMPK–ULK1 pathway, but not the mTOR pathway, plays a crucial role on pHe-regulated autophagy and cardiomyocyte viability. These data provide a potential therapeutic strategy against cardiomyocyte injury triggered by pH fluctuations.” http://onlinelibrary.wiley.com/doi/10.1002/1873-3468.12359/full
HEADACHES are common on the first day for new dry fasters and those not experienced with KETOSIS. It usually takes place around the 18 hour mark and goes away after a few hours. This is the brain switching off glucose and now using ketones for fuel. The headache could also be symptomatic of caffeine withdrawal. Totally normal; push through, it passes.
50% INCREASE IN LIFESPAN —
BY COMPLETE ABSENCE OF FOOD
“Remarkably, the greatest increase in lifespan was observed …maintained in the complete absence of food, with a 50% increase in median and maximum lifespan relative to control-fed animals.”
INCREASES LIFESPAN UP TO 60%
“Dietary Restriction (DR) increases the rodent lifespan by up to 60% in part by delaying the occurrence of many chronic diseases, and in part by slowing the rate of biological or physiological aging (1).
Among its many protective effects of DR described in mice, the most notable include those on increasing insulin sensitivity and on the attenuation of B amyloid deposition in a model for Alzheimer’s Disease (54). Severe dietary restriction or STARVATION (dry fasting) may also be applicable to disease treatment. For example, fasting protects mice against high dose chemotherapy in part by reducing serum IGF-I signalling but does not protect cancer cells, since oncogene mutations prevent the activation of the stress resistance pathways in response to the reduction in glucose, IGF-I and other growth factors caused by nutrient deprivation (55).”
“The higher the metabolism speed, the shorter the lifespan, and vice versa.”
YOU DO NOT WANT A FAST METABOLISM.
Over 24 weeks, a low-carbohydrate diet program led to greater weight loss, reduction in serum triglyceride level, and increase in HDL cholesterol level compared with a low-fat diet.
THE STARVATION TREATMENT OF DIABETES
Adiponectin is associated with longevity and heightened insulin sensitivity and has anti cancer properties; it is a hormone excreted primarily from adipose tissue(fat). Fasting is exceptional for releasing Adiponectin and preventing adhd not to mention inhibiting disease and prolonging life.
Centenarians and high Adiponectin levels
FGF21 (the starvation hormone) FASTING & LONGEVITY
Fibroblast growth factor-21 (FGF21) is a hormone secreted by the liver during fasting that elicits diverse aspects of the adaptive starvation response. Among its effects, FGF21 induces hepatic fatty acid oxidation and ketogenesis, increases insulin sensitivity, blocks somatic growth and causes bone loss. Here we show that transgenic overexpression of FGF21 markedly extends lifespan in mice without reducing food intake or affecting markers of NAD+ metabolism or AMP kinase and mTOR signaling. Transcriptomic analysis suggests that FGF21 acts primarily by blunting the growth hormone/insulin-like growth factor-1 signaling pathway in liver. These findings raise the possibility that FGF21 can be used to extend lifespan in other species.
FGF21 is specifically induced by HMGCS2 activity. The oxidized form of ketone bodies (acetoacetate) in a cultured medium also induced FGF21, possibly via a SIRT1-dependent mechanism. HMGCS2 activity has also been shown to be increased by deacetylation of lysines 310, 447, and 473 via SIRT3 in the mitochondria.
While FGF21 is expressed in numerous tissues, including liver, brown adipose tissue, white adipose tissue and pancreas, circulating levels of FGF21 are derived specifically from the liver in mice. In liver FGF21 expression is regulated by PPARα and levels rise substantially with both FASTING and consumption of ketogenic diets.
FULVIC ACID and the importance of minerals
Watch the light bulb demonstration: Www.purefulvicminerals.com
Your body is just like a battery; no minerals—no electricity. “All life is Electric”.
A CONCEPTUAL REVOLUTION OF BIBLICAL PROPORTIONS
“The previously unknown capacity of human body to uses water as source of electrons is an astonishing finding that is a conceptual revolution of biblical proportions. The sacred role of glucose as source of energy now is broken into small pieces. Therefore human body build up its biomass arising from glucose, thereby carbohydrates (or meals) are just a source of carbon chains of different lengths, branching; combinations with other elements and so forth. We could say that glucose (C6 H12O6 ) is the perfect building block. Our body is able to synthesize even nucleic acids with it. But our body fulfills its energy needs by means of the unexpected and astonishing capacity of melanin to split and re-form the water molecule. “
For constipation or bowel issues:
1TBS of Milk of Magnesia should do the trick
AMPK ACTIVATORS & MTOR INHIBITORS
At the start or end of your dry fast, or as a brief interval for instance in mornings, to increase mTOR inhibition, AMPK activation and maintain autophagy effects do a 4-6 oz cup of decaf coffee, INTERSTELLAR BLEND (longevity herbs www.interstellarblend.com), and mct or coconut oil (see below). This addition will provide energy and clarity all day long without engaging mTOR pathway, halting autophagy or deactivating AMPK — plus you won’t be hungry or craving anything. As far as why no caffeine? Stimulants overly tax adrenals and prematurely age you; save caffeine for special occasions. If you research the anti aging herbs in the blend you will see why this is a wise decision to add to your daily regiment and if you choose to drink it upon rising or as an intermission you are maintaining calorie (carb/protein) restriction (mTOR inhibition/AMPK activation/autophagy) until feeding window. You can also skip this altogether and drink this at feeding window and dry fast straight through the 18-20 hours. Explore both options to find best fit.
Herbs in blend that inhibit mTOR:
Reishi, Astragalus, He Shou Wu, Rhodiola
Polygonum (he shou wu)
Purchase INTERSTELLAR BLEND here: www.interstellarblend.com
Chart of longevity herbs here:
List of tonic herbs here:
REMEMBER: The less you drink the faster the fast works so if you do the morning drink keep it to 4-6 oz. Don’t ingest anything else until feeding/exercise window.
FOR LONGER DRY FASTS 3+ DAYS (preparation)
As the dry fast progresses urine ph will drop and continue to drop until you break fast. (Ketone bodies are acidic in nature.)
ALWAYS, ALWAYS, ALWAYS alkalinize urine before and again after TO PROTECT KIDNEYS AND AVOID KIDNEY STONES. This is easily accomplished by drinking 1 teaspoon of baking soda in 8oz water.
*IF you foolishly skip this step don’t cry about getting a kidney stone or having kidney pain in the group as you were STRONGLY WARNED TO ALKALINIZE and dissolve all acid formed crystals in urinary tract before hand.
WHY USE BAKING SODA FOR PREVENTING KIDNEY STONES OR KIDNEY PROBLEMS?
Because it works and fast!
I recommend raising urine ph to an 8 NOT 7 as in study before long dry fasts and once again after.
PH STRIPS TO TEST URINE: http://www.amazon.com/…/…/B00LY1KIWY/ref=zg_bs_3013605011_10
Conclusions: Bicarbonate therapy remains an attractive option for the treatment of radiolucent kidney stones. The presence of hyperuricaemia or hyperuricosuria appears to influence the success rate. Further prospective randomised studies are needed to identify the most tolerable and effective treatment regime as well as the optimal duration of treatment. Dual-energy CT may hold the key to identifying patients most likely to benefit from treatment.
2. CELLULAR ELECTRICITY
I recommend “charging” cells with trace minerals via Fulvic acid. Use either Shilajit or Fulvic mineral source. Without electricity you have no energy. WATCH light bulb demo: http://www.purefulvicminerals.com/product-comparison
3. AMPK ACTIVATORS/ MTOR INHIBITORS
I always utilize before hand to jump start the process SUPERTONIC HERBS that activate AMPK and inhibit mTOR and promote autophagy like what’s in Interstellar Blend. www.interstellarblend.com
4. THIRST AND HEAT
The body heats up the longer you go because the cells are incinerating junk via autophagy. Thirst may become intense. I recommend ICE BATHS & ICE SHOWERS to cool down and keep going. You will find this blissfully rejuvenating.
5. STUDY THIS POST AND THE LINKS. The more informed you are the less fear you will have and the greater resolve to not quit.
6. DEHYDRATION WORRIES
Skin tenting purportedly begins at 15% body water loss. At 7 days I had zero skin tenting still. NOBODY in group is in danger of dehydration in 72 hours. Nobody. Unless maybe you are in Death Valley, CA in 120+ degree heat sitting there sweating.
****IF YOU GOT FAT YOU GOT WATER.****
So have ZERO FEAR of going 3 days your first time. Alkalinize and launch!
What is skin tenting or skin turgor test???
BLOOD PRESSURE CONCERNS
Be not overly concerned by blood pressure irregularities; the body as it acclimates itself to survival conditions corrects itself the longer you go. It may fluctuate up and down the first 3 days but by day 4 and onward it stabilizes.
Blood pressure and resting pulse without fail on all extended dry fasts (beyond 3 days) goes down and this is very positive.
Have no fear or worries; perfectly natural process.
BUT WHAT ABOUT GLUCOSE REQUIREMENTS ON A DRY FAST AND THE LOSS OF MUSCLE ???
Won’t my muscles be broken down to create critical glucose required by certain organs and red blood cells (that don’t have mitochondria and can’t run on ketones) through the process of gluconeogenesis? Good question. Let me ask you this: “If I designed the body and made it to where under starvation conditions critical muscle was broken down BEFORE fat would you think I was a very intelligent designer???” No I didn’t think so; that would be utterly ridiculous and foolish. Glucose CAN and IS created from fat and here’s how it works:
So the real source of energy of the eukaryotic cell is water, so the sacred role of glucose as an energy source now breaks into a thousand pieces. We ended up saying that if the energy source was glucose, diabetic patients would fly.
The human body with four billion years of evolution is far beyond our ability to abstraction, but in origin the body is relatively simple: everything comes, everything is soaked, and everything is governed by photosynthesis, both in plants and in us. http://www.ncbi.nlm.nih.gov/…/P…/pdf/1878-5085-5-S1-A146.pdf
MELANIN THE HUMAN CHLOROPHYLL
“The main source of energy of the eukaryotic cell is water, not ATP. The profound misconception that food, glucose or ATP are the main source of energy has its basis in the lack of knowledge of the hitherto unknown capacity of melanin to split the water molecule . Until today, the fact that human tissues have the capability to take hydrogen from water—the energy carrier by excellence in the whole Universe—arising from the splitting of water, as plants do, was totally unknown before our work.It was unthinkable that an expensive chemical reaction, from the energetic point of view, such as water dissociation, that requires 2000˚C in the laboratory to take place, might occur at room temperature in our body. The sole possibility seemed berserk. However, our studies researching the three main causes of blindness allowed us to detect the hitherto unknown fact that melanin is the “human chlorophyll”. This amazing compound absorbs photonic energy and transforms it into chemical energy.”
GLUCONEOGENESIS FROM FAT
“That sugar can be converted into fatty acids in humans is a well-known fact. The question whether the reverse direction, i.e., gluconeogenesis from fatty acids, is also feasible has been a topic of intense debate since the end of the 19th century. With the discovery of the glyoxylate shunt that allows this conversion in some bacteria, plants, fungi and nematodes it has been considered infeasible in humans since the corresponding enzymes could not be detected. However, by this finding only a single route for gluconeogenesis from fatty acids has been ruled out. To address the question whether there might exist alternative routes in humans we searched for gluconeogenic routes from fatty acids in a metabolic network comprising all reactions known to take place in humans.
****Thus, we were able to identify several pathways showing that this conversion is indeed feasible.****
Analyzing evidence concerning the detected pathways lends support to their importance during times of starvation, fasting, carbohydrate reduced and ketogenic diets and other situations in which the nutrition is low on carbohydrates. Moreover, the energetic investment required for this pathway can help to explain the particular efficiency of carbohydrate reduced and ketogenic diets such as the Atkins diet.”
HEAT ON DRY FASTS
Sauna, hot tub, sun exposure, steam room, intense exercise causing profuse sweating NOT ADVISED on long dry fasts— over 24 hours. Under 24 hours it can be used to speed up ketosis induction.
Worry is misuse of your imagination; a form of self sabotage. Willfully replace all worry with joyous optimism and courage. Say to worry, “And if that perchance happens I will face it too gracefully and skillfully as I have many obstacles and challenges in my life thus far; I have no fear or worry. I am a fighter until the end. Now skedaddle worry! BE GONE FROM MY MIND. “
KETONES IDEAL FUEL FOR BODY
“Ketones are the ideal fuel for our bodies unlike glucose – which is damaging, less stable, more excitatory and in fact shortens your life span. Ketones are non-glycating, which is to say, they don’t have a caramelizing ageing effect on your body. A healthy ketosis also helps starve cancer cells as they are unable to use ketones for fuel, relying on glucose alone for their growth.
The energy producing factories of our cells – the mitochondria – work much better on a ketogenic diet as they are able to increase energy levels in a stable, long-burning, efficient, and steady way. Not only that, a ketogenic diet induces epigenetic changes which increases the energetic output of our mitochondria, reduces the production of damaging free radicals, and favours the production of GABA – a major inhibitory brain chemical. GABA has an essential relaxing influence and its favored production by ketosis also reduces the toxic effects of excitatory pathways in our brains. Furthermore, recent data suggests that ketosis alleviates pain in addition to having an overall anti-inflammatory effect. 
The ketogenic diet acts on multiple levels at once, something that no drug has been able to mimic. This is because mitochondria are specifically designed to use fat for energy. When our mitochondria use fat as an energetic source, its toxic load is decreased, the expression of energy producing genes are increased, its energetic output is increased, and the load of inflammatory energetic-end-products is decreased.
The key of these miraculous healing effects relies on the fact that fat metabolism and its generation of ketone bodies (beta-hydroxybutyrate and acetoacetate) by the liver can only occur within the mitochondrion, leaving chemicals within the cell but outside the mitochondria readily available to stimulate powerful anti-inflammatory antioxidants. The status of our mitochondria is the ultimate key for optimal health and while it is true that some of us might need extra support in the form of nutritional supplementation to heal these much needed energy factories, the diet still remains the ultimate key for a proper balance.” More here: http://www.drmyhill.co.uk/…/Ketogenic_diet_-_a_connection_b…
FASTING RELEASES HUMAN GROWTH HORMONE
“HGH secretion was assessed in 7 men during a control period and during starvation. Plasma samples were collected hourly for 24 hr in each period. Starvation for 72 hr increased growth hormone secretion in each individual. Overall, fasting resulted in a 2½ to 3-fold increase of growth hormone secretion. Secretion of hGH was greater in premenopausal women than in men during a control period, but no significant increase of hGH secretion occurred in women after 72 hr of fasting.” – See more at:
TRUE KETOSIS VS FAKE KETOSIS
True ketosis comes from starvation (fasting) or severe carbohydrate restriction. There are no high glucose levels under these conditions. The ketones come from the actual break down of body fat.
False ketosis is the result of coconut oil or mct oil. These provide ketones while being able to eat massive amounts of carbohydrates. The ketones are NOT coming from body fat but the coconut or mct oil. Yes ketostix will say you are in ketosis but you are really in fake ketosis.
You want TRUE not fake ketosis. Avoid coconut or mct oil until you are in TRUE ketosis and maintain less than 30g carbs a day.
IF you are at optimal weight and not trying to lose fat then yes coconut or mct oil and low glycemic load carbohydrates is not a problem.
*For someone on a KETOGENIC diet for epileptic purposes this gives them the advantage of more carbs. For someone trying to lose fat this is a disadvantage because your body will use the coconut oil ketones over body fat ketones for energy.
ALCOHOL STOPS FAT LOSS
The quickest way to halt weight loss and put on fat is alcohol. Why? Because alcohol is the body’s first choice to burn for fuel. Guess what happens to any food you mix with it? That’s right it goes straight to your waistline until the alcohol is burned off.
AVOID alcohol until you reach ideal weight. The fastest way to get over alcohol addiction is a 72 hour dry fast— your brain is purged clean with ZERO CRAVINGS.
HERES TONS OF ARTICLES ON IT: https://www.google.com/search…
SUGAR: PURE, WHITE AND DEADLY
The type of food recommended should be low glycemic load. Chart here: http://www.lowglycemicload.com/glycemic_table.html
You want minimal insulin spikes. Insulin and insulin resistance rapidly ages you. More here: https://scholar.google.com/scholar…
Vegan or non vegan isn’t as important as balanced and nutrient dense. If you are vegan be vegan if you feel best with plants and meat do that. DO EAT PLANTS regardless.
Meat should only be eaten alone or with vegetables never starch or fruit. Salad, meat fish or chicken is a perfect pairing.
If vegan be sure to choose low glycemic load vegetables, fruits, nuts seeds and grains. http://www.lowglycemicload.com/glycemic_table.html (stay as close to 15 as possible)
VEGAN KETO IDEAS: http://ketomotive.com/vegan-ketogenic-diet/
LOW CARB VEGETARIAN IDEAS:
LOW GLYCEMIC LOAD FRUITS:
What about fruit juice fasting??
Waste of time and money; here’s why:
#1 A detox without autophagy IS NOT A DETOX. Autophagy means “to eat self” — that would be the junk weak sick cellular matter.
#2 Autophagy is induced by ketosis which is induced by fasting or extreme protein/carbohydrate restriction.
#3 A fast is NOT drinking a bunch of sugary bottled fruit juice which does NOT induce either ketosis or autophagy.
***Next person that wants to sell you a “detox kit” ask them point blank, “Does this inhibit mTOR, activate AMPK, promote autophagy or induce ketosis?”
If they look at you like a deer in headlights say, “No thanks.”***
Fructose which converts in liver to Glucose halts not only Ketosis but mTOR inhibition, AMPK activation AND autophagy (the whole point of fasting!!!) especially if you ingest more than 30g a day— thats about one 8oz glass of fruit juice. So instead of “juice feasting” all day long accomplishing nothing but wasting a bunch of money and overdosing on fructose an intelligent strategy would be to eat your fruit whole WITH IT’S FIBER (less blood sugar spikes) at the BEGINNING of your feeding window/pre workout.
Fruit without fiber is straight fructose.
Here’s what’s wrong with too much fructose:
Fructose Utilization and Associated Metabolic Dysfunction
“Consumption of fructose has been shown to be highly correlated with the development of diabetes, obesity and the metabolic syndrome. Consumption of soft drinks (high in HFCS) is associated with an increased risk for obesity in adolescents and for type 2 diabetes in young and middle-aged women. Excess fruit juice (also rich in fructose) is associated with the development of obesity in children.
Consumption of fructose by laboratory animals results in their developing several features of metabolic syndrome, including obesity, visceral fat accumulation, fatty liver, and elevated insulin and leptin levels. It is likely that the increase in leptin following fructose consumption represents leptin resistance, which could account for the increased food intake observed in fructose-fed animals.”
Choose high nitric oxide producing plants like beets and arugula. More on nitric oxide and longevity here:
Cancer and its relationship with metabolism, calorie restriction, mTOR inhibition, AMPK activation, autophagy and glucose:
AVOID ADDING SUGAR TO ANYTHING.
LIST OF GLUCOSE DISPOSAL AGENTS.
You DO NOT want your blood sugar spiking and releasing insulin. You want the highest insulin sensitivity possible. These Glucose Disposal Agents in conjunction with dry fasting can assist in regulating blood sugar.
R-Alpha Lipoic Acid (R-ALA), an active isomer of Lipoic Acid, is easily synthesized and metabolized by the body. R-ALA is 2 times more effective than regular (RS) Alpha Lipoic Acid and is a key component of mitochondrial dehydrogenase, which may help to slow the natural aging process in animals. Alpha lipoic acid is known as the “universal antioxidant” because of its unique solubility in both water and fat. It has the ability to conserve and prolong the life of vitamins C & E in the body, increasing their effectiveness. Alpha lipoic acid is also an excellent metal detoxifier, particularly for mercury and cadmium, which it binds to and neutralizes for excretion.
2. BITTER MELON & ANTIDIABETIC AMPK ACTIVATION
Four cucurbitane glycosides, momordicosides Q, R, S, and T, and stereochemistry-established karaviloside XI, were isolated from the vegetable bitter melon (Momordica charantia). These compounds and their aglycones exhibited a number of biologic effects beneficial to diabetes and obesity. In both L6 myotubes and 3T3-L1 adipocytes, they stimulated GLUT4 translocation to the cell membrane—an essential step for inducible glucose entry into cells. This was associated with increased activity of AMP-activated protein kinase (AMPK), a key pathway mediating glucose uptake and fatty acid oxidation. Furthermore, momordicoside(s) enhanced fatty acid oxidation and glucose disposal during glucose tolerance tests in both insulin-sensitive and insulin-resistant mice. These findings indicate that cucurbitane triterpenoids, the characteristic constituents of M. charantia, may provide leads as a class of therapeutics for diabetes and obesity.
3. Gymnema sylvestre
Gymnema sylvestre is native to India, and its leaves are a traditional folk medicine for diabetes. Several studies in humans and animals have confirmed it can improve glucose control, possibly by inhibiting glucose uptake in the small intestine and enhancing insulin release. It may even have positive effects on lipid metabolism and has potential for use in treating diabetes and obesity.
Phellodendron amurense is otherwise known as “Amur Cork Tree.” A native of Asia, the bark has been used in Chinese traditional medicine to treat gastrointestinal problems, ulcers, diabetes and infections. Berberine is the best characterized of the compounds that have been identified. Berberine has antibacterial, anti-tumor and antioxidant activities. It may also have anti-diabetic activity: in one study, it decreased body fat and fasting glucose levels in rats. This work is not conclusive, however, as the berberine was administered by injection, not consumed orally. Unfortunately, we don’t have many other in-vivo studies on berberine or Phellodendron.
Chromium Picolinate or Chromium Polynicotinate or Chromium FTG or chelated Chromium a nutritional form of the essential mineral chromium, as a safe nutritional supplement that may reduce the risk of insulin resistance and possibly type 2 diabetes. One small study suggests that chromium picolinate may reduce the risk of insulin resistance, and therefore possibly may reduce the risk of type 2 diabetes. FDA concludes, however, that the existence of such a relationship between chromium picolinate and either insulin resistance or type 2 diabetes is highly uncertain. Chromium Polynicotinate is a niacin bound form of chromium picolinate which is considered less potentially toxic with better absorbsion qualities while FTG and the chelated form of chromium are from organic sources and considered the safest of all.
6. Vanadyl Sulfate
Under normal conditions, the body contains 20 to 25 mg. of vanadium, and the average diet supplies about 2 mg. of vanadium per day. Food sources rich in vanadium include pepper, dill, radishes, eggs, vegetable oils, buckwheat and oats. Because of their organic environment, these natural sources are likely to be safer than over the counter preparations.
7. Ceylon Cinnamon
There has been a lot of talk these days about cinnamon. According to some studies, cinnamon may improve blood glucose and cholesterol levels in people with Type 2 diabetes. The results of a study from 2003 in Pakistan showed lower levels of fasting glucose, triglycerides, LDL cholesterol and total cholesterol after 40 days with levels continuing to drop for 20 days after that.
You can lower blood sugar with apple cider vinegar, which has long been valued for its nutritive properties as a folk remedy. The health benefits and effect of apple cider vinegar on blood glucose levels has been clinically researched.
9. Corosolic Acid
Corosolic acid, a triterpenoid found in the leaves, helps regulate blood sugar by stimulating glucose uptake. This blood sugar lowering effect is similar to that of insulin – which induces glucose transport from the blood into body cells. In a study of humans with type-2 diabetes, banaba extract showed a 30% reduction in blood glucose levels. It is considered a natural plant insulin, can be taken orally, and has no side effects, according to Japanese research. Corsolic acid also appears to have strong antioxidant properties.
10. Extracts of Fenugreek
The chemical compounds found in fenugreek have the ability to aid the digestive process. Consequently, when taken with meals it is believed that fenugreek is able to slow down the rate at which sugars are absorbed into the body, whereby regulating blood sugar levels. Additionally, studies indicate that 4-hydroxyisoleucine (an amino acid) found in fenugreek may induce or promote the production of insulin when blood sugar levels are elevated.
Cissus quadrangularis is also known as “Veld Grape.” It’s another medicinal plant native to Africa, India, and other parts of Asia. Cissus has traditionally been used to treat a variety of ailments such as bone fractures, ulcers, wounds, indigestion and asthma. Animal studies have shown Cissus extracts may have gastroprotective effects, contribute to bone health, and have antioxidant/antimicrobial activities. A number of people swear by Cissus as an analgesic and use it to treat weight lifting injuries. Lately, Cissus has also been touted as a fat loss agent, thanks to two studies.The first was discussed by Paul in his review of Cylaris. Of course, this study actually tested the entire Cylaris formula—which makes it difficult to draw conclusions about Cissus itself. A second study, however, did test a proprietary Cissus extract (CQR-300) and concluded it “…brought about significant reductions in weight and blood glucose levels, while decreasing serum lipids thus improving cardiovascular risk factors.”
12. Phellodendron extract
Anti-inflammatory, antipyretic, cholagogue, antibacterial, lowers blood sugar.
13. BMOV (Bis-Malto-Oxovanadium)
BMOV is an organic form of the mineral vanadium. Although elemental vanadium and inorganic salts of vanadium show significant biological potential, it has a poor therapeutic index due to low gastrointestinal absorbance. BMOV is recognized as safer, more absorbable, and able to deliver a therapeutic effect up to 50% greater than the inorganic forms. Vanadium is one of the rare microelements that can promote a profound boost in endurance and strongly support anabolism.
(Na RALA is the sodium salt form of R-Lipoic Acid) Sodium R-Lipoate (Na-r-ALA)
ALA is naturally produced in the body as a mitochondrial enzyme cofactor. It is important to aerobic metabolism. ALA has been shown to increase cellular uptake of glucose to cell membranes by recruiting the glucose transporter GLUT4. ALA improves skeletal muscle glucose transport, resulting in desirable blood glucose disposal and increased muscle glycogen concentrations. Studies also indicate that in muscle, ALA is a potent anti-oxidant which protects cells from oxidative stress-induced insulin resistance. ALA is an invaluable addition that offers a multitude of benefits plus countless extras for any serious athlete.
15. Magnolia officinalis
Magnolia bark is used as a general anti-stress and anti-anxiety agent – so its claims typically center on general benefits in controlling stress and anxiety. Newer claims are emerging, however, to link magnolia’s anti-stress benefits with control of the body’s primary stress hormone, cortisol, and the myriad health benefits associated with normal cortisol levels (versus elevated cortisol, which has been associated with obesity, diabetes, osteoporosis, memory problems and suppressed immune function).
Lagerstroemia speciosa is Banaba—a tree native to Southeast Asia. The leaves have been used in traditional medicine in the Phillipines as a treatment for diabetes. As it turns out, the leaves are high in corosolic acid, which has been shown to improve glucose control in human and animal studies. It appears to do this by stimulating glucose uptake in muscle cells. Glucose transport is mediated by specific transporter proteins. Corosolic acid acts by increasing the amount of a particular transporter (GLUT-4) on the cell membrane surface. Although more work remains to be done, banaba looks like a useful ingredient for treating hyperglycemia and diabetes.
17. Gynostemma Pentaphyllum (in Interstellar Blend)
“Gynostemma pentaphyllum is a plant distantly related to the cucumber. In traditional Asian medicine, it’s used to promote longevity. Today’s scientists have discovered why Asian doctors prescribed G. pentaphyllum to address age-related health issues: It promotes AMPK activation.
G. pentaphyllum not only activates AMPK, but it also shuttles excess fats into the mitochondria to be utilized for energy and safe disposal. The result is efficient energy production and a sharp reduction in unnecessary fat storage.
Results of G. pentaphyllum-induced AMPK activation include increased fat burning, as well as an increase in cellular glucose uptake. Extracts of G. pentaphyllum have other beneficial properties as well, including the ability to prolong cellular life in the face of stresses induced by oxidation, fat accumulation, and diabetes.
When scientists began exploring the benefits of G. pentaphyllum for AMPK activation, they turned to animal studies. What they found was that leaf extracts of G. pentaphyllum activate AMPK, resulting in reduced body weight gain and fat accumulation. In a preclinical study, obese mice supplemented with G. pentaphyllum showed impressive declines in markers associated with obesity and its related diseases.
In another study, this time using diabetic rats, three weeks of G. pentaphyllum supplementation resulted in improved glucose tolerance by 35% and reduced new glucose production in the liver by 29%, with a reduction in liver glycogen, the storage form of sugar.
These results show the enormous beneficial impact of reducing circulating sugar and fats in response to AMPK activation by G. pentaphyllum.
Human studies have confirmed what many of the researchers had found in the lab: G. pentaphyllum boosts AMPK activity and provides important longevity benefits.
In a compelling human study, type II diabetics who were not using diabetic medications drank a tea made with G. pentaphyllum. The results compared to controls were:
A 5-fold reduction in fasting glucose,
A 10-fold reduction in hemoglobin A1c, a measure of chronic glucose exposure,
A near 3-fold decrease in insulin resistance,
No dangerously low blood sugar episodes, which can often occur with certain oral antidiabetic drugs (especially sulfonylurea class drugs). In another human study, those taking G. pentaphyllum significantly boosted the effects of a sulfonylurea antidiabetic drug, producing an additional fasting glucose reduction of 52.2 mg/dL compared with just 16.2 mg/dL for the drug alone.
None of these findings should be surprising since the prescription drug metformin, which is an AMPK activator, produces many of these same benefits.” http://www.lifeextension.com/magazine/2014/ss/ampk/page-01
What would I do with my current understanding if I had cancer?
Well it can survive with glucose, fructose and amino acids…. So what’s left?
Fat. What else is associated with that? Fasting—which leads to ketosis which leads to mTOR inhibition, AMPK activation, autophagy as well as p53, sirt1, foxo and a whole bunch of other anti cancer stuff.
I would basically dry fast and hold deep level ketosis (160) along with KETOGENIC diet until I killed it.
I would also employ longevity herbs or agents that inhibited mTOR, activated AMPK and promoted autophagy like what’s in Interstellar Blend— Gynostemma, Reishi, Ginseng, Astragalus, Rhodiola, He Shou Wu etc the drugs Metformin and Rapamycin would be of interest as well.
I would definitely NOT be eating fruit or any glucose or fructose containing foods; I would also be VERY careful on protein; in fact I might just nix all 3 until cancer aborted. Fat only diet. Coconut oil a few times a day might do the trick and provide required energy aside from body fat reserves.
I would also use baking soda or milk of magnesia to keep my body ph alkaline while deep level ketosis.
To keep nitric oxide levels high I would employ neo40 or arugula.
Last but not least I would watch lots of comedies, read lots of funny things and laugh as often as possible—I would keep all negativity of any form out of my mind.
You conquer fear by facing it.
A dry fast is the conquering of fear. Fear of what? Fear of going without food, fear of going without water, without pills, without vitamins, supplements, weed, nicotine, caffeine, alcohol, drugs….whatever.
That’s right, fear of the unknown. Fear of death. Fear of losing control. Fear of breaking. Fear of being vulnerable. Fear of failing. Fear of being revealed.
To the timid this seems like insanity.
No training wheels, filters, buffers, numbing agents, masks, props or diversions— just YOU and nothing else—nowhere to run and nothing to hide behind.
The body a sealed vessel….
THIS is how true strength of character and true strength of will is forged.
No mere mortals dry fast.
These ARE no ordinary human beings.
These are EXTRAORDINARY BEINGS.
“No water or food you say?”
DANGERS OF CHRONIC DEHYDRATION
You DO NOT want to stay chronically dehydrated; some people confuse dry fasting as a way of life; like never drink water. This is idiotic. It is HORMESIS which is like a little taste of death to stress test the system and ideally eradicate disease and weakness in the process. The dose makes the poison. IF you stay in a dehydrated state you over express certain hormones and other things to try and counteract this to survive that will cause all sorts of problems like metabolic syndrome and cardiovascular issues as well as blunt and hinder some of the anti aging mechanisms in your body. When you are NOT dry fasting you should be HYDRATING— big time.
One example of this is chronic dehydration over expresses the water storing hormone aldosterone which also in the process shuts down klotho the anti aging gene; this causes a bunch of problems and premature mortality.
“Downregulation of Klotho expression by dehydration
Klotho, a transmembrane protein, protease, and hormone mainly expressed in renal tissue counteracts aging. Overexpression of Klotho substantially prolongs the life span. Klotho deficiency leads to excessive formation of 1,25(OH)2D3, growth deficit, accelerated aging, and early death. Aging is frequently paralleled by dehydration, which is considered to accelerate the development of age-related disorders. The present study explored the possibility that dehydration influences Klotho expression. Klotho transcript levels were determined by RT-PCR, and Klotho protein abundance was detected by Western blotting in renal tissue from hydrated and 36-h-dehydrated mice as well as in human embryonic kidney (HEK293) cells. Dehydration was followed by a significant decline of renal Klotho transcript levels and protein abundance, accompanied by an increase in plasma osmolarity as well as plasma ADH, aldosterone, and 1,25(OH)2D3 levels. Antidiuretic hormone (ADH; 50 nM) and aldosterone (1 μM) significantly decreased Klotho transcription and protein expression in HEK293 cells. In conclusion, the present observations disclose a powerful effect of dehydration on Klotho expression, an effect at least partially mediated by enhanced release of ADH and aldosterone.”
Dehydration: a new modulator of klothoexpression
What’s the lesson?
Use dry fasting as a tool not as a way of life keeping an individual in a state of chronic dehydration.
There is a time to dry fast and a time to be well hydrated. Intelligence is knowing when to apply each.