Sansalvamide A (MArine Fungi Fusarium)
January 15, 2020
Solidago virgaurea
January 15, 2020
Silybin (Milk Thistle)
- A comparative study on enzyme kinetics of diastereoisomeric silybin A and silybin B glucuronidation in rat liver microsome
- A comparative study on the stability of silybin and that in silymarin in buffers and biological fluids.
- A Comparison of Spray-Drying and Freeze-Drying for the Production of Stable silybin Nanosuspensions
- A comparison of the diastereoisomers, silybin A and silybin B, on the induction of apoptosis in K562 cells
- A long-term treatment with silybin in patients with non-alcoholic steatohepatitis stimulates catalase activity in human endothelial cells
- A new drug nanocrystal self-stabilized Pickering emulsion for oral delivery of silybin
- A New Pro-Prodrug Aminoacid-Based for Trans-Ferulic Acid and silybin Intestinal Release
- A new silybin-vitamin E-phospholipid complex improves insulin resistance and liver damage in patients with non-alcoholic fatty liver disease: preliminary observations
- A novel approach for the efficient extraction of silybin from milk thistle fruits
- A phase I and pharmacokinetic study of silybin-phytosome in prostate cancer patients
- A phase I dose-finding study of silybin phosphatidylcholine (milk thistle) in patients with advanced hepatocellular carcinoma
- A pilot study on the liver protective effect of silybin-phosphatidylcholine complex (IdB1016) in chronic active hepatitis.
- A presurgical study of oral silybin-phosphatidylcholine in patients with early breast cancer
- A randomized multicentre double-blind vs placebo trial: Evaluation of effect of silybin conjugated with phosphatidilcholine and vitamin E on liver damage in patients …
- A review of the bioavailability and clinical efficacy of milk thistle phytosome: a silybin-phosphatidylcholine complex (Siliphos).
- A silybin-phospholipid complex prevents mitochondrial dysfunction in a rodent model of nonalcoholic steatohepatitis
- A silybin-phospholipids complex counteracts rat fatty liver degeneration and mitochondrial oxidative changes
- A Simple HPLC Method for the Quantitative Determination of silybin in Rat Plasma: Application to a Comparative Pharmacokinetic Study on Commercial Silymarin …
- A study of high‐dose oral silybin‐phytosome followed by prostatectomy in patients with localized prostate cancer
- Ability of silybin and its derivatives to prevent protein oxidation in different model systems
- Absorption characteristics of silybin-phospholipid complex by rat intestine.
- Abstract A58: Green tea and silybin for breast cancer: A pilot presurgical study
- Abstract# 4510: A pilot study of oral silybin-phytosome followed by prostatectomy in patients with localized prostate cancer
- Acetaminophen does not induce oxidative stress in isolated rat hepatocytes: its probable antioxidant effect is potentiated by the flavonoid silybin
- Activation of sirtuin 3 by silybin attenuates mitochondrial dysfunction in cisplatin-induced acute kidney injury
- ADME/Tox Properties and Biochemical Interactions of silybin Congeners: In silico Study
- Advances in Chemical Modification of silybin and Its Analogues.
- Advances in the Researches on Derivatives of silybin [J]
- Alterations in insulin receptor in injured rats and the effects of dexamethasone and silybin
- Ameliorative effect of silybin on bisphenol A induced oxidative stress, cell proliferation and steroid hormones oxidation in HepG2 cell cultures
- Anti-cancer efficacy of silybin derivatives-a structure-activity relationship
- Anti-inflammatory effects of silybin and Thioctic acid in lipopolysaccharide (LPS)-induced BV-2 murine microglia
- Antioxidant activity of silybin and 2, 3-dehydrosilybin from Silybum marianum (L). Gaertn. Fruits
- Antioxidant activity of silybin in vivo during long-term iron overload in rats
- Antioxidant and antiviral activities of silybin fatty acid conjugates
- Antioxidant properties of silybin glycosides
- Antioxidant properties of the flavonoids silybin and (+)-cyanidanol-3: comparison with butylated hydroxyanisole and butylated hydroxytoluene
- Antiproliferative effect of silybin on gynaecological malignancies: synergism with cisplatin and doxorubicin
- Antitumour activity of the silybin-phosphatidylcholine complex, IdB 1016, against human ovarian cancer
- Apoptosis effect of HepG2 cell induced by silybin-phosphatidylcholine compound [J]
- Aquaporin-9 is involved in the lipid-lowering activity of the nutraceutical silybin on hepatocytes through modulation of autophagy and lipid droplets composition
- Baicalein enhances the oral bioavailability and hepatoprotective effects of silybin through inhibiting efflux transporters BCRP and MRP2
- Base-catalyzed oxidation of silybin and isosilybin into 2, 3-dehydro derivatives
- Bax/tubulin/epithelial-
mesenchymal pathways determine the efficacy of silybin analog HM015k in colorectal cancer cell growth and metastasis - Benzodioxans by oxidative phenol coupling. Synthesis of silybin
- Bile-salt effect on the dissociation of silybin
- Bioavailability of a silybin–phosphatidylcholine complex in dogs
- Biocatalytic synthesis and antitumor activities of novel silybin acylated derivatives with dicarboxylic acids
- Bioconversion of silybin to phase I and II microbial metabolites with retained antioxidant activity
- Biomimetic synthesis of natural silybin
- Biotransformation of silibinin (silybin) using fungal organisms
- Biotransformation of silybin and its congeners
- Changes of gut microbiota during silybin mediated treatment of high‐fat diet‐induced nonalcoholic fatty liver diseasein mouse
- Changes of liver microsomal drug-metabolizing system and lipoperoxidation activity in scalded rats and the effects of silybin
- CHANGES OF LIVER MICROSOMAL DRUG-METABOLIZING SYSTEM AND LIPOPEROXIDATION ACTIVITY IN SCALDED RATS AND THE EFFECTS OF silybin [J]
- Characterizing the properties of anticancer silibinin and silybin B complexes with UV–Vis, FT-IR, and Raman spectroscopies: A combined experimental and theoretical …
- Chemistry of silybin
- Chemoenzymatic preparation of silybin β-glucuronides and their biological evaluation
- Chemo-enzymatic synthesis of silybin and 2, 3-dehydrosilybin dimers
- Chromato-spectrophotometric method for the quantitative determination of silybin in Silybum marianum fruits.
- Clinical curative effect and safety of Silybin-nanosuspension in the treatment of liver tumor
- Clinical Efficacy of Combined Ginkgo Leaf and silybin in the Treatment of Nonalcoholic Fatty Liver Diseases
- Clinical efficacy of silybin in 168 patients with fatty liver
- Clinical observation of PHGF joint water silybin in treatment of anti-TB drugs cause liver damage [J]
- Clinical Observation on Treatment of Alcoholic Fatty Liver with Xiaozhi Huoxue Oral Liquid and silybin Meglumine Tablet
- Co-delivery doxorubicin and silybin for anti-hepatoma via enhanced oral hepatic-targeted efficiency
- Combination of taurine with silybin meglumine in treatment of patients with non-alcohlic steatohepatitis
- Combinational applicaton of silybin and tangeretin attenuates the progression of non-alcoholic steatohepatitis (NASH) in mice via modulating lipid metabolism
- Comparative effect of silymarin and silybin treatment on inflammation and oxidative stress in transgenic spontaneously hypertensive rats overexpressing human C …
- Comparative study of the hepatoprotective effect of silymarin and silybin on isolated rat hepatocytes
- Comparative study on optimization of silybin particles preparation by uniform design and orthogonal design
- Comparative treatment of α-amanitin poisoning with N-acetylcysteine, benzylpenicillin, cimetidine, thioctic acid, and silybin in a murine model
- Comparing studies of silybin metabolism in normal rats and liver injury model rats
- Comparing the effect of silybin and silybin advanced™ on viability and HER2 expression on the human breast cancer SKBR3 cell line by no serum starvation
- Comparison and improvement of two methods for refining silybin
- Comparison of the in vitro antifibrogenic effects of silymarin, silybin a and 18α-glycyrrhizin on activated hepatic stellate cells
- Constituents of Silybum marianum. Structure of isosilybin and stereochemistry of silybin
- Content analysis of silybin in Yiganling tablets by RP-HPLC
- Correction to: Superior silybin bioavailability of silybin–phosphatidylcholine complex in oily-medium soft-gel capsules versus conventional silymarin tablets in healthy …
- Curative effect of lamivudine and silybin-lecithin compound on 88 patients with chronic hepatitis B [J]
- Curative effect of silybin combined with pituitrin-phentolamine for pulmonary tuberculosis complicated by acute hemoptysis
- Curcumin, silybin Phytosome® and α‐R‐Lipoic Acid Mitigate Chronic Hepatitis in Rat by Inhibiting Oxidative Stress and Inflammatory Cytokines Production
- Current status of pharmacokinetics and clinical study of silybin-phospholipid complex
- Cytoprotective effect of silybin against lasalocid-induced toxicity in HepG2 cells
- Cytotoxicity of monensin, narasin and salinomycin and their interaction with silybin in HepG2, LMH and L6 cell cultures
- Dehydrosilybin is a better DNA topoisomerase I inhibitor than its parental silybin
- DEPRESSANT EFFECT OF SILYBIN-PHOSPHATIDYLCHOLINE COMPOUND (SPC) ON ADVANCED GLYCATION END PRODUCTS (AGEs) IN ALLOXAN …
- DERIVATIVES OF NATURAL 2, 3-DEHYDRO-silybin AS ANGIOGENESIS MODULATORS
- Design and discovery of silybin analogues as antiproliferative compounds using a ring disjunctive–Based, natural product lead optimization approach
- Design and Pharmacological Development of Novel silybin Analogues as Potent and Selective Antiproliferative Agents
- Design, optimization and in vitro-in vivo evaluation of smart nanocaged carrier delivery of multifunctional PEG-chitosan stabilized silybin nanocrystals
- Design, synthesis, and examination of neuron protective properties of alkenylated and amidated dehydro-silybin derivatives
- Determination of concentration and encapsulation efficiency of silybin liposomes
- Determination of content of silubin in silybin capsule by HPLC
- Determination of entrapment efficiency and drug phase distribution of submicron emulsions loaded silybin
- Determination of Residual Organic Solvent in Silybin-N-Meglumine by Headspace GC [J]
- Determination of silybin B in the Different Parts of Silybum marianum using HPLC-UV
- Determination of silybin in beagle dog plasma by LC/MS
- Determination of silybin in blood plasma using high performance liquid chromatography with solid phase extraction
- Determination of silybin in Fufang Yiganling Tablet by HPLC [J]
- Determination of silybin in health food by high performance liquid chromatography
- Determination of silybin in human plasma by HPLC
- Determination of silybin in human plasma by RP-HPLC
- Determination of silybin in Silymarin and its Preparations by HPLC
- Determination of silybin in the rat plasma by RP-HPLC [J]
- Determination of silybin in Yiganning Dispersible Tablets by HPLC
- Determination of silybin of Nutraceutical Herbal Preparations Using HPLC-PDA
- Determination of the Content and Entrapment Efficiency of silybin Nanostructured Lipid Carrier [J]
- Determination of the entrapment efficiency of silybin liposomes by first derivative spectrometry
- Development of a HPLC-UV assay for silybin-phosphatidylcholine complex (silybinin capsules) and its pharmacokinetic study in healthy male Chinese volunteers
- Differential effect of silybin on the Fe2+-ADP and t-butyl hydroperoxide-induced microsomal lipid peroxidation
- Differential effects of the flavonolignans silybin, silychristin and 2, 3-dehydrosilybin on Mesocestoides vogae larvae (cestoda) under hypoxic and aerobic in …
- Differential transcriptional profiles in HepG2 cells after the exposure to a chemically characterized complex preparation of Silybi mariani fructus and its chemically defined constituent silybin A + B
- Dimerisation Process of Silybin‐Type Flavonolignans: Insights from Theory
- Direct targeting of MEK1/2 and RSK2 by silybin induces cell-cycle arrest and inhibits melanoma cell growth
- Does silybin protect against toxicity induced by polymyxin E in rat kidney?
- Down-regulation of LPCAT expression increases platelet-activating factor level in cirrhotic rat liver: potential antiinflammatory effect of silybin
- Effect of 3‐O‐Galloyl Substitution on the Electrochemical Oxidation of Quercetin and silybin Galloyl Esters at Glassy Carbon Electrode
- Effect of Absorption Enhancers on Intestinal Absorption of silybin and its Phospholipid Complex [J]
- Effect of flavonolignans derived from silybin on mitochondrial production of reactive oxygen species
- EFFECT OF GIBBERELLIC ACID (GA) AND METHANOL SPRAYING ON silybin YIELD IN SILYBUM MARIANUM (L.) GAERTN
- Effect of silybin and its congeners on human liver microsomal cytochrome P450 activities
- Effect of silybin and its glycosides on the expression of cytochromes P450 1A2 and 3A4 in primary cultures of human hepatocytes
- Effect of silybin Capsule on Vascular Endothelial Function in Patients with Non-alcoholic Fatty Liver Disease
- Effect of silybin dihemisuccinate on the ethanol metabolizing systems of the rat liver
- Effect of silybin meglumine Tablets on Treatment of Nonalcoholic Steatohepatitis in Rats [J]
- Effect of silybin on biliary lipid composition in rats
- Effect of silybin on Coxsackie B_5 Virus Infected New Born Rat Heart Cells in Culture
- Effect of silybin on Coxsackie B_5 Virus Infected New Born Rat Heart Cells in Culture [J]
- Effect of silybin on hepatic cell membranes after damage by polycyclic aromatic hydrocarbons (PAH).
- Effect of silybin on high-fat-induced fatty liver in rats
- Effect of silybin on lipid profile in hypercholesterolaemic rats
- Effect of silybin on phalloidin-actin interactions in vitro
- Effect of silybin on phorbol myristate actetate-induced protein kinase C translocation, NADPH oxidase activity and apoptosis in human neutrophils
- Effect of silybin on proliferation and remodeling of vessels after balloon injury
- Effect of silybin on the fibrillation of hen egg‐white lysozyme
- Effect of silybin on the fibrogenic cytokines production by mouse peritoneal macrophages [J]
- Effect of the silybin-phosphatidylcholine complex (IdB 1016) on the development of mammary tumors in HER-2/neu transgenic mice
- Effects of lamivudine combining with silybin on secondary cirrhosis induced by hepatitis B
- Effects of Mediterranean diet supplemented with silybin–vitamin E–phospholipid complex in overweight patients with non-alcoholic fatty liver disease
- Effects of silybin on acute myocardial infarction and reperfusion injury in anesthetized rats
- Effects of silybin on histamine release from human basophil leucocytes.
- EFFECTS OF silybin ON ISOLATED RABBIT PORTAL VEIN AND THORACIC AORTA
- Effects of silybin on mitochondria membrane fluidity in rats with non-alcoholic fatty liver disease
- Effects of silybin on Neointimal Proliferation of Rabbit Iliac Artery after Balloon Injury [J]
- Effects of silybin on production of oxygen free radical, lipoperoxide and leukotrienes in brain following ischemia and reperfusion
- Effects of silybin on red blood cell sorbitol and nerve conduction velocity in diabetic patients
- EFFECTS OF silybin ON REPERFUSION-INDUCED ARRHYTHMIAS AND SUPEROXIDE ANION RADICAL [J]
- Effects of Silybin-phospholipid Complex on Inflammatory Factors of Autoimmune Prostatitis in Rats
- Effects of silymarin and silybin on lipoprotein cholesterol levels and oxidizability of low density lipoproteins in rats
- Effects of silymarin flavonolignans and synthetic silybin derivatives on estrogen and aryl hydrocarbon receptor activation
- Electrospun silybin Enriched Scaffolds of Polyethylene Oxide as Wound Dressings: Enhanced Wound Closure, Reepithelization in Rat Excisional Wound …
- Engineered silybin nanoparticles educe efficient control in experimental diabetes
- Engineering enzymatic cascades for the efficient biotransformation of eugenol and taxifolin to silybin and isosilybin
- Enhanced bioactivity of silybin B methylation products
- Enhanced oral bioavailability of silybin by a supersaturatable self-emulsifying drug delivery system (S-SEDDS)
- Enhancement of oral bioavailability of the poorly water-soluble drug silybin by sodium cholate/phospholipid-mixed micelles
- Enterohepatic Recirculation of Free and Conjugated silybin Following Administration of a Chewing Gum with Milk Thistle Extract I. Grabnar (1), M. Pišlar (1), L. Maggi …
- Enzymatic and Metabolic Transformation of silybin and its Congeners
- Enzymatic kinetic resolution of silybin diastereoisomers
- Enzymatic preparation of acylated derivatives of silybin in organic and ionic liquid media and evaluation of their antitumor proliferative activity
- Enzymatic preparation of silybin phase II metabolites: sulfation using aryl sulfotransferase from rat liver
- Establishment and application of an experimental model of human fetal hepatocytes for investigation of the protective effects of silybin and polyporus umbellalus polysaccharides
- Establishment of culture system of Silybum marianum hairy roots and determination of silybin
- Establishment of Silybum marianum cell suspension culture system and effects of different factors on silybin content
- Eudragit nanoparticles loaded with silybin: a detailed study of preparation, freeze-drying condition and in vitro/in vivo evaluation
- Evaluation of the Effect Derived from silybin with Vitamin D and Vitamin E Administration on Clinical, Metabolic, Endothelial Dysfunction, Oxidative Stress Parameters …
- Evaluation of the genotoxic and anti-genotoxic activities of silybin in human hepatoma cells (HepG2)
- Evidence for differences in regioselective and stereoselective glucuronidation of silybin diastereomers from milk thistle (Silybum marianum) by human UDP …
- Excess fructose and fatty acids trigger a model of non‑alcoholic fatty liver disease progression in vitro: Protective effect of the flavonoid silybin
- Experimental study of silybin-phospholipid complex intervention on amiodarone-induced fatty liver in mice
- Extraction of oil and silybin compounds from milk thistle seeds using supercritical carbon dioxide
- Fast repair activities towards dGMP hydroxyl radical adducts by silybin and its analogues
- Flavonoid silybin improves the response to radiotherapy in invasive bladder cancer
- Formulation and development of silybin loaded solid lipid nanoparticle enriched gel for irritant contact dermatitis
- Formulation development and characterization of silybin loaded nanoparticles
- Formulation of perspective hepatoprotector polymeric forms based on silybin and ursodeoxycholic acid
- Free radical scavenging reactions and antioxidant activities of silybin: mechanistic aspects and pulse radiolytic studies
- Free‐radical scavenging activities of silybin and its analogues: A pulse radiolysis study
- Glycosylation of silybin
- Gram-positive bacteria specific properties of silybin derived fromSilybum marianum
- he flavano-lignan flavanone derivatives silandrin, silybin and silychristin from Silibum marianum (Asteraceae) are antihepatotoxic. Sanggenon C and sanggenon D bind to the phorbol ester binding site on protein kinase C (PKC). Dihydroflavonols
- Heat capacity for the binary system of silybin and poly (vinylpyrrolidone) K30
- Heat Capacity for the Binary System of silybin and Sodium Cholate
- Hepatoprotective Activity of Xanthones and Xanthonolignoids Against tert-Butylhydroperoxide-
Induced Toxicity in Isolated Rat Hepatocytes—Comparison with Silybin - Hepatoprotective and antifibrotic effect of a new silybin–phosphatidylcholine–
vitamin E complex in rats - Hepatoprotective effects of S‐adenosylmethionine and silybin on canine hepatocytes in vitro
- HiFSA fingerprinting applied to isomers with near-identical NMR spectra: the silybin/isosilybin case
- High-Affinity Binding of silybin Derivatives
- High-affinity binding of silybin derivatives to the nucleotide-binding domain of a Leishmania tropicaP-glycoprotein-like transporter and chemosensitization of a …
- Highly sensitive detection of silybin based on adsorptive stripping analysis at single-sided heated screen-printed carbon electrodes modified with multi-walled carbon …
- HM015k, a novel silybin derivative, multi-targets metastatic ovarian cancer cells and is safe in zebrafish toxicity studies
- How the presence of metal atoms and clusters can modify the properties of Silybin? A computational prediction
- HPLC-MS/MS study on pharmacokinetics of silybin A and silybin B in rat plasma
- Identification and initial SAR of silybin: an Hsp90 inhibitor
- Identification of 23-(s)-2-amino-3-
phenylpropanoyl-silybin as an antiviral agent for influenza A virus infection in vitro and in vivo - Improving bioavailability of silybin by inclusion into SBA-15 mesoporous silica materials
- In vitro and in vivo evaluation of silybin nanoparticles for liver cancer
- In vitro and in vivo evaluation of silybin nanosuspensions for oral and intravenous delivery
- In vitro antitumor activity of silybin nanosuspension in PC-3 cells
- In vitro inhibitory effects of major bioactive constituents of Andrographis paniculata, Curcuma longa and Silybum marianum on human liver microsomal morphine glucuronidation: A prediction of potential herb-drug interactions arising from andrographolide, curcumin and silybin inhibition in humans
- In Vitro Micropropagation of Silybum marianum L from Various Explants and silybin Content
- In Vitro Release and Bioavailability of silybin from Micelle-Templated Porous Calcium Phosphate Microparticles
- In vitro release and in vitro–in vivo correlation for silybin meglumine incorporated into hollow-type mesoporous silica nanoparticles
- In vivo absorption comparison of nanotechnology-based silybin tablets with its water-soluble derivative
- In vivo evaluation of silybin nanosuspensions targeting liver
- In vivo fate of lipid-silybin conjugate nanoparticles: implications on enhanced oral bioavailability
- Increase in rat liver synthesis of fatty acids and glycerol phospholipids following parenteral application of silybin-dihemisuccinate
- Influence of Expression of Intercellular Adhesion Molecule-1 on Cerebral Ischemic Reperfusion Injury and Cerebral Protective of Silybin-lecithin Compound in …
- Influence of silybin on biophysical properties of phospholipid bilayers1
- Influence of silybin on hepatic fibrosis indexes in patients with chronic hepatitis B
- Influence of Silybin-dihemisuccinate on fatty acid synthesis in rat liver (author’s transl)
- Inhibition of glucose uptake by silybin and Dehydrosilybin
- Inhibition of rat liver cytosolic glutathione S-transferase by silybin
- Inhibition of SIRT1 signaling sensitizes the antitumor activity of silybin against human lung adenocarcinoma cells in vitro and in vivo
- Inhibitory effect of silybin on pharmacokinetics of imatinib in vivo and in vitro
- Inhibitory effect of silybin on the activity of 5-lipoxygenase of the porcine cerebral basilar artery
- Inhibitory Effect of Silybin-Phosphatidylcholine Compound on the Activation of Nuclear Factor-? B and Phosphorylation of Inhibitors of Nuclear Factor-? B? in …
- Inhibitory Effect of Silybin-Phosphatidylcholine Compound on the Activation of Nuclear Factor-kappa B and Phosphorylation of Inhibitors of Nuclear Factor-kappa B …
- Inhibitory effects of silybin on the efflux pump of methicillin‑resistant Staphylococcus aureus
- Investigation on the binding interaction between silybin and pepsin by spectral and molecular docking
- Investigations on the actions of silybin on regenerating rat liver. Effects on Kupffer’s cells.
- In-Vitro Activity of silybin and Related Flavonolignans against Leishmania infantum and L. donovani
- Iron-induced oxidant stress in nonparenchymal liver cells: mitochondrial derangement and fibrosis in acutely iron-dosed gerbils and its prevention by silybin
- Iron-induced oxidant stress leads to irreversible mitochondrial dysfunctions and fibrosis in the liver of chronic iron-dosed gerbils. The effect of silybin
- Is silybin the best free radical scavenger compound in silymarin?
- Isolation and purification of silychristin, silydianin and taxifolin in the co-products of the silybin refined process from the silymarin by high-speed counter-current …
- Isolation of diastereoisomers from silybin and determination silybin by HPLC [J]
- IV-23 Iztok Grabnar Enterohepatic Recirculation of Free and Conjugated silybin Following Administration of a Chewing Gum with Milk Thistle Extract
- Laccase-mediated dimerization of the flavonolignan silybin
- Large-scale separation of silybin diastereoisomers using lipases
- Laser photolysis and pulse radiolysis studies on silybin in ethanol solutions
- Linear regression analysis of silychristin A, silybin A and silybin B contents in Silybum marianum
- Lipid peroxidation and irreversible damage in the rat hepatocyte model: protection by the silybin-phospholipid complex IdB 1016
- Liquid chromatographic assay of silybin in human plasma and urine
- Liver Disease in Diabetes Mellitus: Potential Therapeutic Value of Vitamin E-silybin Phytosomal Complex
- Liver Targeting Albumin-Coated Silybin-Phospholipid Particles Prepared by Nab™ Technology for Improving Treatment Effect of Acute Liver Damage in Intravenous …
- Liver-targeting self-assembled hyaluronic acid-glycyrrhetinic acid micelles enhance hepato-protective effect of silybin after oral administration
- Matrix metallopeptidase 9 targeted by hsa‐miR‐494 promotes silybin‐inhibited osteosarcoma
- Mechanism of Phospholipid Complex and its SNEDDS Enhancing the Oral Bioavailability of Silybin
- Mechanism of silybin action, III. Resorption of the flavonolignane derivative silybin into rat liver cells (author’s transl)
- Mechanism of silybin action, IV. Structure-action relationship (author’s transl)
- Mechanism of the antioxidant action of silybin and 2, 3-dehydrosilybin flavonolignans: a joint experimental and theoretical study
- Mechanism of the stimulation of RNA synthesis in rat liver nuclei by silybin
- Mechanism-Based Inhibitory and Peroxisome Proliferator-Activated Receptor α–Dependent Modulating Effects of silybin on Principal Hepatic Drug-Metabolizing …
- Mechanism-Based Inhibitory and PPARα-Dependent Modulating Effects of silybin on Principle Hepatic Drug-Metabolizing Enzymes
- Mechanisms of the Prevention and Treatment of Prostate Cancer by Silybin
- Media effects on the mechanism of antioxidant action of silybin and 2, 3-dehydrosilybin: Role of the enol group
- Meta-analysis of the Therapeutic Effect of Silybin-phospholipid Complex in the Treatment of Fatty Liver
- Metabolic and vascular effects of silybin in hypertensive patients with high 1-h post-load plasma glucose
- Metabolic fingerprinting to understand therapeutic effects and mechanisms of silybin on acute liver damage in rat
- Metabonomic Study of Hepato-protective Effect of silybin for the Carbon Tetrachloride Induced Liver Injure in Mice [J]
- Metal coordination protocol for the synthesis of-2, 3-dehydrosilybin and 19-O-demethyl-2, 3-dehydrosilybin from silybin and their antitumor activities
- Micellar liquid chromatographic determination of ribavirin, silybin, interferon α 2A, lamivudine, and ursodeoxycholic acid in dosage forms and biological fluids
- Microbial transformation of silybin by Trichoderma koningii
- Microfluidic fabrication of silybin nanodispersion with high dissolution rate and tunable sizes
- Micronization of silybin by the emulsion solvent diffusion method
- Milk Thistle Extract/Silymarin/Silybin
- Milk thistle’s active components silybin and isosilybin: novel inhibitors of PXR-mediated CYP3A4 induction
- Mixed micelles loaded with silybin-polyene phosphatidylcholine complex improve drug solubility
- Modulation of human polymorphonuclear leukocyte function by the flavonoid silybin.
- Modulatory effects of curcumin, silybin-phytosome and alpha-R-lipoic acid against thioacetamide-induced liver cirrhosis in rats
- Molecular and biochemical evidence on the protective role of ellagic acid and silybin against oxidative stress-induced cellular aging
- Molecular interaction of silybin with hyaluronidase: a spectroscopic and molecular docking study
- Molecular mechanisms of silybin and 2, 3-dehydrosilybin antiradical activity—role of individual hydroxyl groups
- Molecular Structure and Stereochemistry of silybin A, silybin B, Isosilybin A, and Isosilybin B, Isolated from Silybum marianum (Milk Thistle)
- Nanoemulsions as delivery systems of hydrophobic silybin from silymarin extract: effect of oil type on silybin solubility, in vitro bioaccessibility and stability
- Nanostructured calcium phosphate carriers for deliver of poor water-soluble drug silybin
- Nanostructured lipid carriers for parenteral delivery of silybin: Biodistribution and pharmacokinetic studies
- Narrow‐bore core–shell particles and monolithic columns in the analysis of silybin diastereoisomers
- New C-23 modified of silybin and 2, 3-dehydrosilybin: Synthesis and preliminary evaluation of antioxidant properties
- New derivatives of silybin and 2, 3-dehydrosilybin and their cytotoxic and P-glycoprotein modulatory activity
- New silybin scaffold for chemical diversification: Synthesis of novel 23-phosphodiester silybin conjugates
- Observation on efficacy of silybin capsule for chronic hepatitis B
- Observation on Efficacy of silybin Capsule in Treatment of Non-Alcoholic Fatty Liver [J]
- Optimisation of enzyme assisted extraction of silybin from the seeds of Silybum marianum by Box–Behnken experimental design
- Oxidation of the flavonolignan silybin. In situ EPR evidence of the spin-trapped silybin radical
- Oxidised derivatives of silybin and their antiradical and antioxidant activity
- Partially PEGylated PAMAM dendrimers as solubility enhancers of Silybin
- Peroxidase isoenzymes in cress seedlings (Lepidium sativum L.) and their inhibition by silybin, silydianin and silychristin
- Peroxyl Radical Scavenging Capacity of the Flavonolignan Silybin, Ginkgo Biloba Extract EGb 761, American Green Tea and a Series of Germacranolides
- Pharmacokinetic studies on IdB 1016, a silybin-phosphatidylcholine complex, in healthy human subjects
- Pharmacokinetics and Tissue Distribution in Rats by Injection Use of silybin Meglumine Salt
- Pharmacokinetics and Tissue Distribution of silybin Gelatin Microspheres In vivo in Rats [J]
- Pharmacokinetics of pure silybin diastereoisomers and identification of their metabolites in rat plasma
- Pharmacokinetics of silybin A and silybin B in Rat by HPLC-MS/MS
- Pharmacokinetics of silybin following oral administration of silipide in patients with extrahepatic biliary obstruction.
- Pharmacokinetics of silybin in bile following administration of silipide and silymarin in cholecystectomy patients.
- Pharmacokinetics of silybin nanoparticles in mice bearing SKOV-3 human ovarian carcinoma xenocraft
- Pharmacotherapy of Amanita phalloides poisoning using silybin
- Physicochemical characteristic and pharmacokinetics of silybin lipid microsphere [J]
- Phyto-liposomes as nanoshuttles for water-insoluble silybin–phospholipid complex
- Piperine enhances the bioavailability of silybin via inhibition of efflux transporters BCRP and MRP2
- Placental aldose reductase inhibition by silybin (preliminary communication).
- Plasma concentrations of free and conjugated silybin after oral intake of a silybin-phosphatidylcholine complex (silipide) in healthy volunteers.
- Polyamidoamine dendrimers as potential drug carriers for enhanced aqueous solubility and oral bioavailability of silybin
- Polyporus Umbellalus Ploysaccharides and silybin in protecting ultrostructure of human fetal hepatocytes injured by CCL_4
- Positive effects of different drug forms of silybin in the treatment of metabolic syndrome
- Possible protective role of silybin against polymyxin E‐induced toxic effect in rat kidneys: A biochemical approach
- Potent direct or TNF-α-promoted anticancer effects of 2, 3-dehydrosilybin: Comparison study with silybin
- Preliminary clinical development of silipide: a new complex of silybin in toxic liver disorders
- Preparation and capability evaluation of oral microemulsion silybin
- Preparation and characterization of silybin-loaded nanostructured lipid carriers
- Preparation and evaluation of silybin nanocrystallines self-stabilizing Pickering emulsion
- Preparation and in vitro dissolution of silybin dispersible tablet
- Preparation and in vitro Release of silybin Gelatin Microsphere [J]
- Preparation and performance evaluation of emulsomes as a drug delivery system for silybin
- Preparation and properties of a silybin-phospholipid complex
- Preparation and Quality Control of silybin Meglumine Ophthalmic Gel
- Preparation and study on the in vitro release of silybin double-layer tablets
- Preparation of C-23 esterified silybin derivatives and evaluation of their lipid peroxidation inhibitory and DNA protective properties
- Preparation of hollow magnetic molecularly imprinted polymer and its application in silybin recognition and controlled release
- Preparation of self microemulsifying tablet for silybin phospholipid complex and its dissolution [J]
- Preparation of silybin 23-esters and evaluation of their inhibitory ability against LPO and DNA protective properties
- Preparation of silybin and isosilybin sulfates by sulfotransferase from Desulfitobacterium hafniense
- Preparation of silybin lipophilic derivatives and evaluation of their biological activities
- Preparation of silybin nanoemulsion and its pharmacokinetics in rabbits
- Preparation of silybin phase II metabolites: Streptomyces catalyzed glucuronidation
- Preparation of silybin submicron emulsion and study of its biodistribution in rats
- Preparation of silybin/poly (vinylpyrrolidone) nanodrugs by using the aerosol solvent extraction system for improving drug solubility
- Preparation of silybin-phosphatidylcholine compound and identification its physicochemical properties [J]
- Preparation of silybin-phospholipid complex and its bioavailability in rats
- Preparation of tritium‐labeled Silybin—a protectant for common liver diseases
- Preparation, characterisation and in vivo evaluation of silybin nanoparticles for the treatment of liver fibrosis
- Preparation, physico-chemical characterization and in vitro test of a Silybin–phospholipid complex encapsulated into liposomes.
- Preparative chromatographic purification of diastereomers of silybin and their quantification in human plasma by liquid chromatography–tandem mass spectrometry
- Prevention by silybin of phalloidin-induced acute hepatoxicity
- Prevention of praseodymium-induced hepatotoxicity by silybin
- Production of silybin-like compounds in cell suspension cultures of Silybum marianum
- Prophylactic administration of silybin ameliorates L-arginine-induced acute pancreatitis
- Prostate: a study of high-dose oral silybin-phytosome followed by prostatectomy in patients with localized prostate cancer
- Protective effect of silybin against verapamil-induced hepatotoxicity in rats
- Protective effect of silybin Capsules on hepatic injury induced by combining isoniazid with rifampin in mice
- Protective effect of silybin in rats liver toxicity
- Protective effect of silybin meglumine on rats with non-alcoholic fatty liver disease
- Protective Effect of Silybin-Phosphatidylcholine Compound on Acute Liver Damage Induced by Alpha-Naph-thylisothiocyanate in Mice
- Protective Effect of Silybin-phosphatidylcholine Compound on Acute Liver Injury Induced by CHCl_3 in Mice
- Protective effect of silybin-phosphatidylcholine compound on kidney in rats with diabetes [J]
- Protective effect of the flavonoid silybin dihemisuccinate on the toxicity of phenylhydrazine on rat liver
- Protective effects of S-adenosylmethionine (SAMe) and silybin on hepatorenal and hemostatic functions in dogs with endotoxemia
- Protective effects of silybin and analogues against X-ray radiation-induced damage
- Protective effects of silybin and tetrandrine on the outcome of spontaneously hypertensive rats subjected to acute coronary artery occlusion
- Protective effects of silybin Capsules on alcohol-induced hepatic fibrosis in rats
- Protective Effects of silybin on Cultured Cardiomyocytes with Deprivation of Oxygen and Glucose [J]
- Protective effects of silybin on human umbilical vein endothelial cell injury induced by H2O2 in vitro
- Protective effects of silybin-lecithin compound on cerebral ischemic-reperfusion Injury in rats [J]
- Protective effects of silybin-phosphatidylcholine compound on acute liver damage in mice induced by CCl~ 4
- Pulse radiolysis of silybin: one-electron oxidation of the flavonoid at neutral pH
- Quality standard and preliminary secure research on silybin powder for injection
- Quantitative estimation of silybin in Silybum marianum mother tincture using high performance liquid chromatography
- Rapid qualitative analysis of 2 flavonoids, rutin and silybin, in medical pills by direct analysis in real‐time mass spectrometry (DART‐MS) combined with in situ …
- Reactions of silybin, a flavonoid drug, with toxic free radicals
- Recent advances in the nanotechnology-based drug delivery of Silybin
- Regioselective alcoholysis of silybin A and B acetates with lipases
- Regioselective Formation of Silybin-23-β-D-Glucoside by Glucosylation of silybin with Cultured Plant Cells of Eucalyptus Perriniana
- Regorafenib in combination with silybin as a novel potential strategy for the treatment of metastatic colorectal cancer
- Relative bioavailability of silybin A and silybin B from 2 multiconstituent dietary supplement formulations containing milk thistle extract: A single-dose study
- Research on a kind of biocompatible molecularly imprinted materials with silybin controlled release based on pH/temperature dual responses
- Research on the Actions of silybin Disodium Hemisuccinate and Mono-(β-3-Ursolic Acid) Phthalate Disodium on the Primary Cultured Rat Hepatocytes
- Reversing effects of silybin on TAA-induced hepatic CYP3A dysfunction through PXR regulation
- Role of tangeretin as a potential bioavailability enhancer for silybin: Pharmacokinetic and pharmacological studies
- RP-HPLC Determination of silybin in Human Plasma
- Safety and bioavailability in Beagles of zinc and vitamin E combined with silybin and phosphatidylcholine
- Scavenging effect of silipide, a new silybin-phospholipid complex, on ethanol-derived free radicals
- Selective recognition and preliminary separation of hepatoprotective component silybin from milk thistle seeds by the prepared core–shell magnetic molecularly …
- Selective Synthesis of 3-O-Palmitoyl-Silybin, a New-to-Nature Flavonolignan with Increased Protective Action against Oxidative Damages in Lipophilic Media
- Self-assembly and characterization of Pluronic P105 micelles for liver-targeted delivery of silybin
- Separation and characterization of silybin, isosilybin, silydianin and silychristin in milk thistle extract by liquid chromatography–electrospray tandem mass spectrometry
- Seventy-two-hour release formulation of the poorly soluble drug silybin based on porous silica nanoparticles: in vitro release kinetics and in vitro/in vivo correlations in …
- Short-term effect of silybin in capsule and~(131) I treatment in Graves patients with liver damage
- Significantly greater antioxidant anticancer activities of 2, 3-dehydrosilybin than silybin
- Silipide: a new bioavailable complex of silybin
- silybin (silibinin) structure and chirality
- silybin Against Liver Ischemia-Reperfusion Injury: Something Old, Something New…
- silybin alleviates hepatic steatosis and fibrosis in NASH mice by inhibiting oxidative stress and involvement with the Nf-κB pathway
- silybin ameliorates hepatic lipid accumulation and modulates global metabolism in an NAFLD mouse model
- silybin and 2, 3-dehydrosilybin flavonolignans as free radical scavengers
- silybin and dehydrosilybin decrease glucose uptake by inhibiting GLUT proteins
- silybin and dehydrosilybin inhibit cytochrome P450 1A1 catalytic activity: a study in human keratinocytes and human hepatoma cells
- silybin and its bioavailable phospholipid complex (IdB 1016) potentiate in vitro and in vivo the activity of cisplatin
- silybin and metabolic disorders
- silybin and silymarin-new and emerging applications in medicine
- silybin and silymarin-new effects and applications
- silybin and the liver: from basic research to clinical practice
- silybin as therapeutic approach in an in vitro model of NAFLD
- silybin attenuates LPS-induced lung injury in mice by inhibiting NF-κB signaling and NLRP3 activation
- silybin combined with phosphatidylcholine and vitamin E in patients with nonalcoholic fatty liver disease: a randomized controlled trial
- silybin CONJUGATED WITH PHOSPHATIDYLCHOLINE AND VITAMIN E IMPROVES LIVER DAMAGE IN PATIENTS WITH NAFLD: THE RESULTS OF A …
- silybin content and overexpression of chalcone synthase genes in Silybum marianum L. plants under abiotic elicitation
- silybin counteracts doxorubicin resistance by inhibiting GLUT1 expression
- silybin counteracts lipid excess and oxidative stress in cultured steatotic hepatic cells
- silybin decreases erythrocytic sorbitol level and improves peripheral nerve conduction velocity in patients with non-insulin dependent diabetes mellitus
- silybin Derivatives Modulate Thyroid Hormone-Mediated UcP2 Expression in Neonatal Rat Cardiomyocytes
- silybin dihemisuccinate protects against glutathione depletion and lipid peroxidation induced by acetaminophen on rat liver
- silybin dihemisuccinate protects rat erythrocytes against phenylhydrazine-induced lipid peroxidation and hemolysis
- silybin enhances mitochondrial function and inhibits NFkB activation in murine nonalcoholic fatty liver disease
- silybin exerts antioxidant effects and induces mitochondrial biogenesis in liver of rat with secondary biliary cirrhosis
- silybin from Silybum marianum seeds inhibits confluent-induced keratinocytes differentiation as effectively as retinoic acid without inducing inflammatory cytokine
- silybin inactivates cytochromes P450 3A4 and 2C9 and inhibits major hepatic glucuronosyltransferases
- silybin Induces Cell-Cycle Arrest and Inhibits Melanoma Cell Growth by Direct Targeting of MEK1/2 and RSK2
- silybin inhibition of amatoxin uptake in the perfused rat liver.
- silybin inhibition of human T-lymphocyte activation.
- silybin inhibits interleukin‐1β‐induced production of pro‐inflammatory mediators in canine hepatocyte cultures
- silybin inhibits migration of human hepatocellular carcinoma cells and its mechanism
- silybin inhibits NLRP3 inflammasome assembly through the NAD+/SIRT2 pathway in mice with nonalcoholic fatty liver disease
- silybin interacting with Cu4, Ag4 and Au4 clusters: do these constitute antioxidant materials?
- silybin is a direct antifibrogenic and antiinflammatory agent: Cellular and molecular mechanisms
- silybin is metabolized by cytochrome P450 2C8 in vitro
- silybin Modulates Collagen Turnover in an In Vitro Model of NASH
- silybin MONO-GALLATES AND THEIR ANTIANGIOGENIC ACTIVITY
- silybin nanoparticles for liver cancer: development, optimization and in vitro–in vivo evaluation
- silybin reduces lipid peroxidation of rat hepatocyte membrane caused by cyclosporin A
- silybin reduces obliterated retinal capillaries in experimental diabetic retinopathy in rats
- silybin supplementation during HCV therapy with pegylated interferon-α plus ribavirin reduces depression and anxiety and increases work ability
- silybin suppresses cell proliferation and induces apoptosis of multiple myeloma cells via the PI3K/Akt/mTOR signaling pathway
- silybin Synergizes with Wnt3a in Activation of the Wnt/β-catenin Signaling Pathway through Stabilization of Intracellular β-Catenin Protein
- silybin treatment is associated with reduction in serum ferritin in patients with chronic hepatitis C
- Silybin, a component of sylimarin, exerts anti-inflammatory and anti-fibrogenic effects on human hepatic stellate cells
- Silybin, a flavonolignan from milk thistle seeds, restrains the early and advanced glycation end product modification of albumin
- Silybin, a major bioactive component of milk thistle (Silybum marianum L. Gaernt.)—Chemistry, bioavailability, and metabolism
- Silybin, a new iron-chelating agent
- Silybin, a pharmacologically active constituent of Silybum marianum: fragmentation studies by atmospheric pressure chemical ionization quadrupole time‐of …
- Silybin/Silymarin treatment in chronic hepatitis C
- Silybin-beta-cyclodextrin in the treatment of patients with diabetes mellitus and alcoholic liver disease. Efficacy study of a new preparation of an anti-oxidant agent.
- Silybin-conjugated gold nanoparticles for antimicrobial chemotherapy against Gram-negative bacteria
- Silybin-derived flavonolignans and their structure-activity relationships: research advances.
- Silybin-Induced Apoptosis Occurs in Parallel to the Increase of Ceramides Synthesis and miRNAs Secretion in Human Hepatocarcinoma Cells
- Silybin-mediated inhibition of Notch signaling exerts antitumor activity in human hepatocellular carcinoma cells
- Silybin–phosphatidylcholine complex protects human gastric and liver cells from oxidative stress
- Silybin-vitamin E-phospholipids complex reduces liver fibrosis in patients with chronic hepatitis C treated with pegylated interferon α and ribavirin
- Silymarin and silybin in suppression of UVA-induced oxidative stress in normal human dermal fibroblasts
- Silymarin liposomes improves oral bioavailability of silybin besides targeting hepatocytes, and immune cells
- SILYMARIN/silybin AGAINST CANCER
- Silymarin/silybin and chronic liver disease: a marriage of many years
- Simultaneous determination of silybin A and silybin B in rat plasma and pharmacokinetic study
- Simultaneous determination of silybin in shenqigankang capsules by RP-HPLC
- Simultaneous determination of silybin in shenqigankang capsules by RP-HPLC.
- Softgel capsule technology as an enhancer device for the absorption of natural principles in humans. A bioavailability cross-over randomised study on silybin.
- Solid Lipid Nanoparticles and Chitosan-coated Solid Lipid Nanoparticles as Promising Tool for silybin Delivery: Formulation, Characterization, and In vitro Evaluation
- Solubility of silybin in aqueous dextran solutions
- Solubility of silybin in aqueous hydrochloric acid solution