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      BECLIN-1 & AUTOPHAGY
      January 22, 2020
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      PRISTIMERIN
      January 22, 2020
      1. A cell-permeable STAT3 SH2 domain mimetic inhibitor of STAT3 activation inhibits growth of human breast tumor xenografts
      2. A cell-permeable STAT3 SH2 domain mimetic inhibits STAT3 activation and induces antitumor cell effects in vitro
      3. A low-molecular-weight compound discovered through virtual database screening inhibits STAT3 function in breast cancer cells
      4. A membrane penetrating peptide aptamer inhibits STAT3 function and suppresses the growth of STAT3 addicted tumor cells
      5. A millet bran-derived peroxidase inhibits cell migration by antagonizing STAT3-mediated epithelial-mesenchymal transition in human colon cancer
      6. A natural compound derivative P-13 inhibits STAT3 signaling by covalently inhibiting Janus kinase 2
      7. A novel curcumin analog inhibits canonical and non-canonical functions of telomerase through STAT3 and NF-κB inactivation in colorectal cancer cells
      8. A novel imidazole derivate inhibits STAT3 activation via induction of SHP-1 hepatocellular carcinoma
      9. A novel non-phosphorylated potential antitumoral peptide inhibits STAT3 biological activity
      10. A novel platinum compound inhibits constitutive STAT3 signaling and induces cell cycle arrest and apoptosis of malignant cells
      11. A novel small molecular STAT3 inhibitor, LY5, inhibits cell viability, cell migration, and angiogenesis in medulloblastoma cells
      12. A novel small molecule inhibits STAT3 phosphorylation and DNA binding activity and exhibits potent growth suppressive activity in human cancer cells
      13. A novel small molecule STAT3 inhibitor, LY5, inhibits cell viability, colony formation, and migration of colon and liver cancer cells
      14. A novel small molecule, LLL12, inhibits IL-6 induced STAT3 phosphorylation and nuclear translocation
      15. A novel small molecule, LLL12, inhibits STAT3 phosphorylation and activities and exhibits potent growth-suppressive activity in human cancer cells
      16. A novel small molecule, LY5, selectively inhibits STAT3 phosphorylation and activities and exhibits potent growth suppressive activity in cancer cells.
      17. A novel synthetic Asiatic acid derivative induces apoptosis and inhibits proliferation and mobility of gastric cancer cells by suppressing STAT3 signaling …
      18. A phosphopeptide mimetic prodrug targeting the SH2 domain of STAT3 inhibits tumor growth and angiogenesis
      19. A serine protease extracted from Trichosanthes kirilowii inhibits epithelial-mesenchymal transition via antagonizing PKM2-mediated STAT3/Snail1 pathway in human …
      20. A small molecule compound targeting STAT3 DNA-binding domain inhibits cancer cell proliferation, migration, and invasion
      21. A small molecule, LLL12 inhibits constitutive STAT3 and IL‐6‐induced STAT3 signaling and exhibits potent growth suppressive activity in human multiple myeloma …
      22. Abstract B95: A novel small molecule, LLL12 inhibits STAT3 phosphorylation and activities and exhibits potent growth suppressive activity in human hepatocellular …
      23. Abstract P6-14-13: A Flavone from Traditional East Asian Natural Extract Inhibits STAT3 and Tumor Growth in a Syngeneic Mouse Breast Cancer Model
      24. Abstract# 3693: Sorafenib inhibits STAT3-regulated expression of prosurvival Mcl-1 and Bcl-xL proteins to enhance TRAIL-mediated apoptosis in human pancreatic …
      25. Abstract# 5627: Sorafenib inhibits STAT3 signaling, cell proliferation and survival of human glioblastomas
      26. Allicin Inhibits Proliferation and Invasion in Vitro and in Vivo via SHP-1-Mediated STAT3 Signaling in Cholangiocarcinoma
      27. An ethanolic extract of ampelopsis radix exerts anti-colorectal cancer effects and potently inhibits STAT3 signaling in vitro
      28. APE1/Ref-1 regulates STAT3 transcriptional activity and APE1/Ref-1–STAT3 dual-targeting effectively inhibits pancreatic cancer cell survival
      29. Aphanin, a triterpenoid from Amoora rohituka inhibits K-Ras mutant activity and STAT3 in pancreatic carcinoma cells
      30. Apigenin inhibits STAT3/CD36 signaling axis and reduces visceral obesity
      31. Arctigenin inhibits STAT3 and exhibits anticancer potential in human triple-negative breast cancer therapy
      32. Ascochlorin, an isoprenoid antibiotic inhibits growth and invasion of hepatocellular carcinoma by targeting STAT3 signaling cascade through the induction of PIAS3
      33. Baohuoside I Inhibits Benzo (a) Pyrene-Induced Metastasis in A549 Lung Cancer Cells by Modulating STAT3 and EMT
      34. Bear Bile Powder Inhibits Growth of Hepatocellular Carcinoma via Suppressing STAT3 Signaling Pathway in Mice
      35. Berberine downregulates CDC6 and inhibits proliferation via targeting JAK-STAT3 signaling in keratinocytes
      36. Bigelovin inhibits STAT3 signaling by inactivating JAK2 and induces apoptosis in human cancer cells
      37. Brassinin inhibits STAT3 signaling pathway through modulation of PIAS-3 and SOCS-3 expression and sensitizes human lung cancer xenograft in nude mice …
      38. Brevilin A, a novel natural product, inhibits janus kinase activity and blocks STAT3 signaling in cancer cells
      39. Butoxy Mansonone G Inhibits STAT3 and Akt Signaling Pathways in Non-Small Cell Lung Cancers: Combined Experimental and Theoretical Investigations
      40. Capillarisin inhibits constitutive and inducible STAT3 activation through induction of SHP-1 and SHP-2 tyrosine phosphatases
      41. Capsazepine inhibits JAK/STAT3 signaling, tumor growth, and cell survival in prostate cancer
      42. Carnosic acid inhibits STAT3 signaling and induces apoptosis through generation of ROS in human colon cancer HCT116 cells
      43. Carnosol, a natural polyphenol, inhibits migration, metastasis and tumor growth of breast cancer via a ROS-dependent proteasome degradation of STAT3
      44. CD45 phosphatase inhibits STAT3 transcription factor activity in myeloid cells and promotes tumor-associated macrophage differentiation
      45. CDDO-Me, a synthetic triterpenoid, inhibits expression of IL-6 and STAT3 phosphorylation in multi-drug resistant ovarian cancer cells
      46. Celastrol inhibits proliferation and induces chemosensitization through down‐regulation of NF‐κB and STAT3 regulated gene products in multiple myeloma cells
      47. Celecoxib inhibits interleukin-6/Interleukin-6 receptor–induced JAK2/STAT3 phosphorylation in human hepatocellular carcinoma cells
      48. Celecoxib inhibits STAT3 phosphorylation and suppresses cell migration and colony forming ability in rhabdomyosarcoma cells
      49. Chalcone inhibits the activation of NF-κB and STAT3 in endothelial cells via endogenous electrophile
      50. Chikusetsusaponin IVa butyl ester (CS-IVa-Be), a novel IL6R antagonist, inhibits IL6/STAT3 signaling pathway and induces cancer cell apoptosis
      51. Chrysin induces cell growth arrest, apoptosis, and ER stress and inhibits the activation of STAT3 through the generation of ROS in bladder cancer cells
      52. Chrysin inhibits sphere formation in SMMC-7721 cells via modulation of SHP-1/STAT3 signaling pathway
      53. Constitutive activation of a slowly migrating isoform of STAT3 in mycosis fungoides: tyrphostin AG490 inhibits STAT3 activation and growth of mycosis fungoides tumor …
      54. Constitutive STAT3-activation in Sezary syndrome: tyrphostin AG490 inhibits STAT3-activation, interleukin-2 receptor expression and growth of leukemic …
      55. Cosmomycin C inhibits signal transducer and activator of transcription 3 (STAT3) pathways in MDA-MB-468 breast cancer cell
      56. Costunolide inhibits osteosarcoma growth and metastasis via suppressing STAT3 signal pathway
      57. Crispene E, a cis-clerodane diterpene inhibits STAT3 dimerization in breast cancer cells
      58. Cryptotanshinone inhibits esophageal squamous-cell carcinoma in vitro and in vivo through the suppression of STAT3 activation
      59. Cryptotanshinone inhibits human glioma cell proliferation in vitro and in vivo through SHP-2-dependent inhibition of STAT3 activation
      60. Cryptotanshinone Inhibits STAT3 Signaling to Alleviate Cardiac Fibrosis in Type 1‐like Diabetic Rats
      61. Cucurbitacin B inhibits STAT3 and the Raf/MEK/ERK pathway in leukemia cell line K562
      62. Cucurbitacin E, a tetracyclic triterpenes compound from Chinese medicine, inhibits tumor angiogenesis through VEGFR2-mediated Jak2–STAT3 signaling pathway
      63. Cucurbitacin I inhibits STAT3 and induces apoptosis in Sezary cells
      64. Cucurbitacin I inhibits STAT3, but enhances STAT1 signaling in human cancer cells in vitro through disrupting actin filaments
      65. Curcumin (diferuloylmethane) inhibits constitutive and IL-6-inducible STAT3 phosphorylation in human multiple myeloma cells
      66. Curcumin analogue GO-Y030 inhibits STAT3 activity and cell growth in breast and pancreatic carcinomas
      67. Curcumin inhibits constitutive STAT3 phosphorylation in human pancreatic cancer cell lines and downregulation of survivin/BIRC5 gene expression
      68. Curcumin inhibits cystogenesis in autosomal dominant polycystic kidney disease cells via altering JAK2/STAT3 activity
      69. Curcumin inhibits STAT3 signaling in the colon of dextran sulfate sodium-treated mice
      70. CYTL1 inhibits tumor metastasis with decreasing STAT3 phosphorylation
      71. Debio 0617B inhibits growth of STAT3-driven solid tumors through combined inhibition of JAK, SRC, and class III/V receptor tyrosine kinases
      72. Differentiation-inducing factor-1 (DIF-1) inhibits STAT3 activity involved in gastric cancer cell proliferation via MEK-ERK-dependent pathway
      73. Dihydroartemisinin inhibits endothelial cell tube formation by suppression of the STAT3 signaling pathway
      74. Diosgenin, a steroidal saponin, inhibits STAT3 signaling pathway leading to suppression of proliferation and chemosensitization of human hepatocellular carcinoma …
      75. Disruption of STAT3-DNMT1 interaction by SH-I-14 induces re-expression of tumor suppressor genes and inhibits growth of triple-negative breast tumor
      76. Docosahexaenoic acid (DHA) promotes immunogenic apoptosis in human multiple myeloma cells, induces autophagy and inhibits STAT3 in both tumor and …
      77. Docosahexaenoic Acid Inhibits Helicobacter pylori-induced STAT3 Phosphorylation through Activation of PPARγ.
      78. Docosahexaenoic acid inhibits Helicobacter pylori‐induced STAT3 phosphorylation through activation of PPARγ
      79. Dominant negative STAT3 mutant inhibits interleukin-6-induced Jak-STAT signal transduction
      80. Down-regulation of STAT3 expression by vector-based small interfering RNA inhibits pancreatic cancer growth
      81. EF24 Suppresses Cholangiocellular Carcinoma Progression, Inhibits STAT3 Phosphorylation, and Induces Apoptosis via ROS-Mediated Oxidative Stress
      82. Endoplasmic reticulum stress inhibits STAT3-dependent suppression of hepatic gluconeogenesis via dephosphorylation and deacetylation
      83. Epigenomic characterization of a p53-regulated 3p22. 2 tumor suppressor that inhibits STAT3 phosphorylation via protein docking and is frequently …
      84. Eriocalyxin B inhibits STAT3 signaling by covalently targeting STAT3 and blocking phosphorylation and activation of STAT3
      85. Esculetin Inhibits Proliferation, Invasion, and Migration of Laryngeal Cancer In Vitro and In Vivo by Inhibiting Janus Kinas (JAK)-Signal Transducer and …
      86. Ethanol rapidly inhibits IL‐6‐activated STAT3 and C/EBP mRNA expression in freshly isolated rat hepatocytes
      87. Eupatilin inhibits gastric cancer cell growth by blocking STAT3-mediated VEGF expression
      88. Evodiamine inhibits STAT3 signaling by inducing phosphatase shatterproof 1 in hepatocellular carcinoma cells
      89. FoxO1 inhibits leptin regulation of pro-opiomelanocortin promoter activity by blocking STAT3 interaction with specificity protein 1
      90. FTY720 inhibits proliferation and epithelial-mesenchymal transition in cholangiocarcinoma by inactivating STAT3 signaling
      91. Functional graphene oxide as a plasmid-based STAT3 siRNA carrier inhibits mouse malignant melanoma growth in vivo
      92. Gambogic acid inhibits STAT3 phosphorylation through activation of protein tyrosine phosphatase SHP-1: potential role in proliferation and apoptosis
      93. Genistein inhibits angiogenesis developed during rheumatoid arthritis through the IL-6/JAK2/STAT3/VEGF signalling pathway
      94. Geranylnaringenin (CG902) inhibits constitutive and inducible STAT3 activation through the activation of SHP-2 tyrosine phosphatase
      95. Ginsenoside 20 (S)‑Rg3 inhibits the Warburg effect through STAT3 pathways in ovarian cancer cells
      96. GRIM-19 inhibits the STAT3 signaling pathway and sensitizes gastric cancer cells to radiation
      97. Hepatocyte IKKβ/NF-κB inhibits tumor promotion and progression by preventing oxidative stress-driven STAT3 activation
      98. Homoharringtonine induces apoptosis and inhibits STAT3 via IL-6/JAK1/STAT3 signal pathway in Gefitinib-resistant lung cancer cells
      99. Honokiol eliminates glioma/glioblastoma stem cell-like cells via JAK-STAT3 signaling and inhibits tumor progression by targeting epidermal growth factor …
      100. Honokiol inhibits constitutive and inducible STAT3 signaling via PU. 1-induced SHP1 expression in acute myeloid leukemia cells
      101. Honokiol inhibits lung cancer brain metastasis through inhibition of STAT3 signaling pathway
      102. I157172, a novel inhibitor of cystathionine γ-lyase, inhibits growth and migration of breast cancer cells via SIRT1-mediated deacetylation of STAT3
      103. Icaritin inhibits JAK/STAT3 signaling and growth of renal cell carcinoma
      104. IFN-λ inhibits miR-122 transcription through a STAT3-HNF4α inflammatory feedback loop in an IFN-α resistant HCV cell culture system
      105. IFNγ-dependent SOCS3 expression inhibits IL-6-induced STAT3 phosphorylation and differentially affects IL-6 mediated transcriptional responses in endothelial cells
      106. IL-32γ inhibits cancer cell growth through inactivation of NF-κB and STAT3 signals
      107. IL-32θ inhibits stemness and epithelial-mesenchymal transition of cancer stem cells via the STAT3 pathway in colon cancer
      108. IL-6, a risk factor for hepatocellular carcinoma: FLLL32 inhibits IL-6-induced STAT3 phosphorylation in human hepatocellular cancer cells
      109. Ilamycin C induces apoptosis and inhibits migration and invasion in triple-negative breast cancer by suppressing IL-6/STAT3 pathway
      110. Inositol Polyphosphate-5-Phosphatase F (INPP5F) inhibits STAT3 activity and suppresses gliomas tumorigenicity
      111. Interleukin 37 expression inhibits STAT3 to suppress the proliferation and invasion of human cervical cancer cells
      112. Isoharringtonine inhibits breast cancer stem-like properties and STAT3 signaling
      113. Isoliquiritigenin inhibits the proliferation of human renal carcinoma Caki cells through the ROS-mediated regulation of the Jak2/STAT3 pathway
      114. Janus kinase 2 inhibitor AG490 inhibits the STAT3 signaling pathway by suppressing protein translation of gp130
      115. Kaempferia parviflora Extract Inhibits STAT3 Activation and Interleukin-6 Production in HeLa Cervical Cancer Cells
      116. Knockdown of STAT3 expression by RNA interference inhibits the induction of breast tumors in immunocompetent mice
      117. Let-7a Inhibits T-Cell Proliferation and IFN-γ Secretion by Down-Regulating STAT3 Expression in Patients with Psoriasis
      118. LLL-3 inhibits STAT3 activity, suppresses glioblastoma cell growth and prolongs survival in a mouse glioblastoma model
      119. LLL12 inhibits endogenous and exogenous interleukin-6-induced STAT3 phosphorylation in human pancreatic cancer cells
      120. Long non-coding RNA TPTEP1 inhibits hepatocellular carcinoma progression by suppressing STAT3 phosphorylation
      121. LRIG1 inhibits STAT3-dependent inflammation to maintain corneal homeostasis
      122. LTP-1, a novel antimitotic agent and STAT3 inhibitor, inhibits human pancreatic carcinomas in vitro and in vivo
      123. Lumbar puncture-administered resveratrol inhibits STAT3 activation, enhancing autophagy and apoptosis in orthotopic rat glioblastomas
      124. Lycorine inhibits the growth and metastasis of breast cancer through the blockage of STAT3 signaling pathway
      125. LYR71, a derivative of trimeric resveratrol, inhibits tumorigenesis by blocking STAT3-mediated matrix metalloproteinase 9 expression
      126. Manumycin inhibits STAT3, telomerase activity, and growth of glioma cells by elevating intracellular reactive oxygen species generation
      127. Metastasis suppressor Nm23-H1 inhibits STAT3 signaling via a negative feedback mechanism
      128. Methyllucidone inhibits STAT3 activity by regulating the expression of the protein tyrosine phosphatase MEG2 in DU145 prostate carcinoma cells
      129. Micheliolide inhibits gastric cancer growth in vitro and in vivo via blockade of the IL-6/STAT3 pathway
      130. MicroRNA in vivo precipitation identifies miR-151-3p as a computational unpredictable miRNA to target STAT3 and inhibits innate IL-6 production
      131. miR-1181 inhibits invasion and proliferation via STAT3 in pancreatic cancer
      132. miR-124 inhibits STAT3 signaling to enhance T cell-mediated immune clearance of
      133. MiR-124 inhibits STAT3 signaling to enhance T cell–mediated immune clearance of glioma
      134. Morin inhibits STAT3 tyrosine 705 phosphorylation in tumor cells through activation of protein tyrosine phosphatase SHP1
      135. Natural product pectolinarigenin inhibits osteosarcoma growth and metastasis via SHP-1-mediated STAT3 signaling inhibition
      136. Natural small molecule bigelovin suppresses orthotopic colorectal tumor growth and inhibits colorectal cancer metastasis via IL6/STAT3 pathway
      137. Niclosamide Inhibits Cell Growth and Enhances Drug Sensitivity of Hepatocellular Carcinoma Cells via STAT3 Signaling Pathway
      138. Nimbolide-induced oxidative stress abrogates STAT3 signaling cascade and inhibits tumor growth in transgenic adenocarcinoma of mouse prostate model
      139. Nobiletin inhibits angiogenesis by regulating Src/FAK/STAT3-mediated signaling through PXN in ER+ breast cancer cells
      140. Novel Carbazole Inhibits Phospho-STAT3 through Induction of Protein–Tyrosine Phosphatase PTPN6
      141. Novel small molecule, XZH‐5, inhibits constitutive and interleukin‐6‐induced STAT3 phosphorylation in human rhabdomyosarcoma cells
      142. Nuclear protein IκB-ζ inhibits the activity of STAT3
      143. Obatoclax analog SC-2001 inhibits STAT3 phosphorylation through enhancing SHP-1 expression and induces apoptosis in human breast cancer cells
      144. Obatoclax analogue SC-2001 inhibits STAT3 phosphorylation by enhancing protein tyrosine phosphatase SHP-1 expression and induces apoptosis in human breast …
      145. Oleanolic acid inhibits macrophage differentiation into the M2 phenotype and glioblastoma cell proliferation by suppressing the activation of STAT3
      146. Osthole inhibits triple negative breast cancer cells by suppressing STAT3
      147. Overexpressed HO-1 is associated with reduced STAT3 activation in preeclampsia placenta and inhibits STAT3 phosphorylation in placental JEG-3 cells …
      148. p14 ARF inhibits the growth of lung adenocarcinoma cells harbouring an EGFR L858R mutation by activating a STAT3-dependent pro-apoptotic signalling …
      149. Paeoniflorin inhibits human glioma cells via STAT3 degradation by the ubiquitin–proteasome pathway
      150. Parthenolide inhibits STAT3 signaling and attenuates angiotensin II-induced left ventricular hypertrophy via modulation of fibroblast activity
      151. Parthenolide inhibits STAT3 signaling by covalently targeting Janus kinases
      152. PDLIM2 inhibits T helper 17 cell development and granulomatous inflammation through degradation of STAT3
      153. Penta-1, 2, 3, 4, 6-O-galloyl-β-d-glucose induces p53 and inhibits STAT3 in prostate cancer cells in vitro and suppresses prostate xenograft tumor growth in vivo
      154. Pentagalloylglucose inhibits the replication of rabies virus via mediating the miR-455/SOCS3/STAT3/IL-6 pathway
      155. Pentoxifylline inhibits melanoma tumor growth and angiogenesis by targeting STAT3 signaling pathway
      156. Periplocin of cortex periplocae inhibits STAT3 signaling and induces apoptosis in human hepatocellular carcinoma cell line SMMC-7721
      157. Phenethyl isothiocyanate inhibits STAT3 activation in prostate cancer cells
      158. Piperine inhibits IL-1β-induced IL-6 expression by suppressing p38 MAPK and STAT3 activation in gastric cancer cells
      159. Piperlongumine derivative, CG-06, inhibits STAT3 activity by direct binding to STAT3 and regulating the reactive oxygen species in DU145 prostate carcinoma cells
      160. Platelet factor 4 inhibits IL-17/STAT3 pathway via upregulation of SOCS3 expression in melanoma
      161. Plumbagin inhibits prostate cancer development in TRAMP mice via targeting PKCε, STAT3 and neuroendocrine markers
      162. Plumbagin inhibits prostate carcinogenesis in intact and castrated PTEN knockout mice via targeting PKCε, STAT3, and epithelial-to-mesenchymal transition markers
      163. Plumericin inhibits proliferation of vascular smooth muscle cells by blocking STAT3 signaling via S-glutathionylation
      164. Ponatinib inhibits STAT3 activity and reduces colorectal cancer growth
      165. Prolonged insulin treatment inhibits GH signaling via STAT3 and STAT1
      166. Proscillaridin A induces apoptosis, inhibits STAT3 activation and augments doxorubicin toxicity in prostate cancer cells
      167. Proscillaridin A promotes oxidative stress and ER stress, inhibits STAT3 activation, and induces apoptosis in A549 lung adenocarcinoma cells
      168. Protopanaxadiol inhibits epithelial–mesenchymal transition of hepatocellular carcinoma by targeting STAT3 pathway
      169. PTPMeg2 inhibits STAT3 transcriptional activity in NIH3 T3/STAT3 CA cell model
      170. Puupehenol natural product inhibits STAT3 signaling and induces antitumor cell effects in vitro against human glioblastoma cells
      171. Pyrrolidine dithiocarbamate inhibits interleukin-6 signaling through impaired STAT3 activation and association with transcriptional coactivators in hepatocytes
      172. Pyrvinium pamoate inhibits proliferation of myeloma/erythroleukemia cells by suppressing mitochondrial respiratory complex I and STAT3
      173. Quercetin abrogates IL-6/STAT3 signaling and inhibits glioblastoma cell line growth and migration
      174. Quercetin exerts anti-melanoma activities and inhibits STAT3 signaling
      175. Resveratrol inhibits hypoxia-induced glioma cell migration and invasion by the p-STAT3/miR-34a axis
      176. Resveratrol inhibits Src and STAT3 signaling and induces the apoptosis of malignant cells containing activated STAT3 protein
      177. Resveratrol inhibits STAT3 signaling pathway through the induction of SOCS-1: Role in apoptosis induction and radiosensitization in head and neck tumor cells
      178. RFX-1-dependent activation of SHP-1 inhibits STAT3 signaling in hepatocellular carcinoma cells
      179. RIP4 inhibits STAT3 signaling to sustain lung adenocarcinoma differentiation
      180. RNA interference targeting STAT3 inhibits growth and induces apoptosis of human prostate cancer cells
      181. RNAi-mediated silencing of Anxa2 inhibits breast cancer cell proliferation by downregulating cyclin D1 in STAT3-dependent pathway
      182. S3I-201, a novel STAT3 inhibitor, inhibits growth of human soft tissue sarcoma cell lines
      183. Santamarine Inhibits NF-кB and STAT3 Activation and Induces Apoptosis in HepG2 Liver Cancer Cells via Oxidative Stress.
      184. Saw palmetto extract inhibits metastasis and antiangiogenesis through STAT3 signal pathway in glioma cell
      185. Scavenging reactive oxygen species selectively inhibits M2 macrophage polarization and their pro-tumorigenic function in part, via STAT3 suppression
      186. Silibinin inhibits constitutive activation of STAT3, and causes caspase activation and apoptotic death of human prostate carcinoma DU145 cells
      187. SIPAR negatively regulates STAT3 signaling and inhibits progression of melanoma
      188. Sorafenib inhibits growth and metastasis of hepatocellular carcinoma by blocking STAT3
      189. Sorafenib inhibits STAT3 activation to enhance TRAIL-mediated apoptosis in human pancreatic cancer cells
      190. SR16388 inhibits STAT3 activation and angiogenesis in lung cancer model
      191. STAT1 inhibits STAT3 activation in esophageal squamous cell carcinoma
      192. STAT3 oligonucleotide inhibits tumor angiogenesis in preclinical models of squamous cell carcinoma
      193. STAT3 silencing with lentivirus inhibits growth and induces apoptosis and differentiation of U251 cells
      194. STAT3/STAT5 blockade by WP1066 inhibits ovarian cancer cell proliferation and induces cell death
      195. Stattic inhibits RANKL-mediated osteoclastogenesis by suppressing activation of STAT3 and NF-κB pathways
      196. Sugiol inhibits STAT3 activity via regulation of transketolase and ROS-mediated ERK activation in DU145 prostate carcinoma cells
      197. Sulphoraphane inhibits STAT3 and its related genes in Du 145 cancer cells
      198. Systemic administration of a cyclic signal transducer and activator of transcription 3 (STAT3) decoy oligonucleotide inhibits tumor growth without inducing …
      199. Tanshinone I inhibits tumor angiogenesis by reducing STAT3 phosphorylation at Tyr705 and hypoxia-induced HIF-1α accumulation in both endothelial and …
      200. Tanshinone IIA inhibits cell proliferation and tumor growth by downregulating STAT3 in human gastric cancer
      201. Tanshinone IIA inhibits epithelial-mesenchymal transition in bladder cancer cells via modulation of STAT3-CCL2 signaling
      202. Targeted blockade of JAK/STAT3 signaling inhibits ovarian carcinoma growth
      203. Targeted Disruption of STAT3 Signaling Inhibits Tumor Growth and Brain Metastases by Caveolin-1 Upregulation
      204. Targeting mitochondrial STAT3 with the novel phospho-valproic acid (MDC-1112) inhibits pancreatic cancer growth in mice
      205. Targeting STAT3 inhibits growth and enhances radiosensitivity in head and neck squamous cell carcinoma
      206. The Antioxidant Alpha-Lipoic Acid Inhibits Proliferation and Invasion of Human Gastric Cancer Cells via Suppression of STAT3-Mediated MUC4 Gene Expression
      207. The fruits of Gleditsia sinensis Lam. inhibits adipogenesis through modulation of mitotic clonal expansion and STAT3 activation in 3T3-L1 cells
      208. The histone deacetylase inhibitor valproic acid inhibits NKG2D expression in natural killer cells through suppression of STAT3 and HDAC3
      209. The Interaction of Specific Peptide Aptamers With the DNA Binding Domain and the Dimerization Domain of the Transcription Factor STAT3 Inhibits Transactivation and …
      210. The intracellular delivery of a recombinant peptide derived from the acidic domain of PIAS3 inhibits STAT3 transactivation and induces tumor cell death
      211. The iron chelator Dp44mT inhibits hepatocellular carcinoma metastasis via N-Myc downstream-regulated gene 2 (NDRG2)/gp130/STAT3 pathway
      212. The JAK2/STAT3 inhibitor pacritinib effectively inhibits patient-derived GBM brain tumor initiating cells in vitro and when used in combination with …
      213. The knock-down of Caveolin-1 inhibits STAT3 signaling in human metastatic lung cancer in vitro
      214. The novel triterpenoid C-28 methyl ester of 2-cyano-3, 12-dioxoolen-1, 9-dien-28-oic acid inhibits metastatic murine breast tumor growth through inactivation of STAT3 …
      215. THE PHARMACOLOGICAL IGF1R-IRS1/2 INHIBITOR OSI-906 REDUCES ERYTHROID PROGENITORS AND INHIBITS STAT3 IN JAK2V617F KNOCKIN …
      216. The rabies virus interferon antagonist P protein interacts with activated STAT3 and inhibits Gp130 receptor signaling
      217. The rGel/BLyS fusion toxin inhibits STAT3 signaling via down-regulation of interleukin-6 receptor in diffuse large B-cell lymphoma
      218. The S52F FOXF1 mutation inhibits STAT3 signaling and causes alveolar capillary dysplasia
      219. The small molecule, LLL12, inhibits STAT3 phosphorylation and induces apoptosis in medulloblastoma and glioblastoma cells
      220. The synthetic triterpenoid (CDDO-Im) inhibits STAT3, as well as IL-17, and improves DSS-induced colitis in mice
      221. The tumor suppressor miR-124 inhibits cell proliferation by targeting STAT3 and functions as a prognostic marker for postoperative NSCLC patients
      222. Therapeutic ablation of gain-of-function mutant p53 in colorectal cancer inhibits STAT3-mediated tumor growth and invasion
      223. Therapeutic targeting of STAT3 (signal transducers and activators of transcription 3) pathway inhibits experimental autoimmune uveitis
      224. Thymoquinone inhibits proliferation in gastric cancer via the STAT3 pathway in vivo and in vitro
      225. TIS21/BTG2/PC3 inhibits interleukin-6 expression via downregulation of STAT3 pathway
      226. Tocilizumab inhibits neuronal cell apoptosis and activates STAT3 in cerebral infarction rat model
      227. Triterpenoid CDDO-methyl ester inhibits the Janus-activated kinase-1 (JAK1)→ signal transducer and activator of transcription-3 (STAT3) pathway by direct inhibition …
      228. Ultrasound targeted microbubble destruction-mediated delivery of a transcription factor decoy inhibits STAT3 signaling and tumor growth
      229. Ursolic acid derivative FZU-03,010 inhibits STAT3 and induces cell cycle arrest and apoptosis in renal and breast cancer cells
      230. Ursolic acid inhibits STAT3 activation pathway leading to suppression of proliferation and chemosensitization of human multiple myeloma cells
      231. Ursolic acid inhibits the growth of colon cancer-initiating cells by targeting STAT3
      232. Withacnistin inhibits recruitment of STAT3 and STAT5 to growth factor and cytokine receptors and induces regression of breast tumours
      233. Withaferin A inhibits JAK/STAT3 signaling and induces apoptosis of human renal carcinoma Caki cells
      234. Withaferin A inhibits STAT3 and induces tumor cell death in neuroblastoma and multiple myeloma
      235. Withaferin-A inhibits colon cancer cell growth by blocking STAT3 transcriptional activity
      236. WP1130, a small molecular weight compound, inhibits JAK2-STAT3 signaling through a unique degradation mechansim
      237. Xanthatin inhibits STAT3 and NF‐κB signalling by covalently binding to JAK and IKK kinases
      238. Xanthohumol inhibits STAT3 activation pathway leading to growth suppression and apoptosis induction in human cholangiocarcinoma cells
      239. XZH-5 inhibits STAT3 phosphorylation and causes apoptosis in human hepatocellular carcinoma cells
      240. XZH-5 inhibits STAT3 phosphorylation and enhances the cytotoxicity of chemotherapeutic drugs in human breast and pancreatic cancer cells
      241. YL064 directly inhibits STAT3 activity to induce apoptosis of multiple myeloma cells
      242. YY1 inhibits the migration and invasion of pancreatic ductal adenocarcinoma by downregulating the FER/STAT3/MMP2 signaling pathway
      243. Zerumbone inhibits growth of hormone refractory prostate cancer cells by inhibiting JAK2/STAT3 pathway and increases paclitaxel sensitivity
      244. β‐caryophyllene oxide inhibits constitutive and inducible STAT3 signaling pathway through induction of the SHP‐1 protein tyrosine phosphatase
      245. (-)-Epigallocatechin-3-gallate inhibits VEGF expression induced by IL-6 via STAT3 in gastric cancer
      246. (-)-Oleocanthal exerts anti-melanoma activities and inhibits STAT3 signaling pathway
      247. (−)-Oleocanthal inhibits growth and metastasis by blocking activation of STAT3 in human hepatocellular carcinoma
      248. 15-Keto prostaglandin E2 inhibits STAT3 signaling in H-Ras transformed mammary epithelial cells
      249. 15-Keto prostaglandin E2 suppresses STAT3 signaling and inhibits breast cancer cell growth and progression
      250. 19-nor-1α-25-dihydroxyvitamin D2 induces gastric cancer cell apoptosis and cell cycle arrest and inhibits STAT3 mediated inflammation
      251. 2-Ethoxystypandrone, a novel small-molecule STAT3 signaling inhibitor from Polygonum cuspidatum, inhibits cell growth and induces apoptosis of HCC cells …
      252. 2-Pyridyl Cyclohexanone Inhibits Activated STAT3 and Promotes Apoptosis of Human Esophageal Squamous Cell Carcinoma Cells
      253. 2′-Hydroxyflavanone inhibits prostate tumor growth through inactivation of AKT/STAT3 signaling and induction of cell apoptosis
      254. 3-Deoxy-2β, 16-dihydroxynagilactone E, a natural compound from Podocarpus nagi, preferentially inhibits JAK2/STAT3 signaling by allosterically interacting with the …
      255. 6-Bromoindirubin-3′-oxime inhibits JAK/STAT3 signaling and induces apoptosis of human melanoma cells
      256. 782 SANGUINARINE INHIBITS STAT3 ACTIVATION AND TUMOR GROWTH IN PROSTATE CANCER CELLS
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