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August 3, 2022POLYPHENOLS AS COVID-19 TREATMENT & PREVENTION
August 3, 2022- Oxidative stress, toxicology, and pharmacology of CYP2E1
- Genetic polymorphism in CYP2E1: Population distribution of CYP2E1 activity
- CYP2E1 and oxidative liver injury by alcohol
- Human CYP2E1 is regulated by miR-378
- Role of CYP2E1 in the Hepatotoxicity of Acetaminophen (∗)
- CYP2E1
- CYP2E1: from ash to nash
- Human hepatic CYP2E1 expression during development
- Ethanol Induces CYP2E1 by Protein Stabilization: ROLE OF UBIQUITIN CONJUGATION IN THE RAPID DEGRADATION OF CYP2E1 (∗)
- Role of CYP2E1 in Diethylnitrosamine-Induced Hepatocarcinogenesis In vivo
- CYP2E1-dependent toxicity and oxidative stress in HepG2 cells
- Different regulation and expression of the human CYP2E1 gene due to the Rsal polymorphism in the 5′-flanking region
- Insulin signaling in the transcriptional and posttranscriptional regulation of CYP2E1 expression
- The CYP2E1-humanized transgenic mouse: role of CYP2E1 in acetaminophen hepatotoxicity
- Role of cytochromes P450 in chemical toxicity and oxidative stress: studies with CYP2E1
- Genetic polymorphism of human CYP2E1: characterization of two variant alleles
- Increased hepatocyte CYP2E1 expression in a rat nutritional model of hepatic steatosis with inflammation
- Reduction of benzene metabolism and toxicity in mice that lack CYP2E1 expression
- CYP2E1 genetic polymorphisms and risk of nasopharyngeal carcinoma in Taiwan
- CYP2E1 and risk of chemically mediated cancers
- Nrf2 is increased by CYP2E1 in rodent liver and HepG2 cells and protects against oxidative stress caused by CYP2E1
- Resistance to carbon tetrachloride-induced hepatotoxicity in mice which lack CYP2E1 expression
- CYP2E1 mediated isoniazid-induced hepatotoxicity in rats
- Chlorzoxazone is metabolized by human CYP1A2 as well as by human CYP2E1.
- CYP2E1 is not involved in early alcohol-induced liver injury
- Ethnic variation in the CYP2E1 gene: polymorphism analysis of 695 African-Americans, European-Americans and Taiwanese.
- Detection and characterization of novel polymorphisms in the CYP2E1 gene.
- Contribution of CYP2E1 and CYP3A to acetaminophen reactive metabolite formation
- CYP2E1: biochemistry, toxicology, regulation and function in ethanol-induced liver injury
- Chlorzoxazone, a selective probe for phenotyping CYP2E1 in humans.
- CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis
- Genetic and dietary predictors of CYP2E1 activity: a phenotyping study in Hawaii Japanese using chlorzoxazone
- CYP2E1—biochemical and toxicological aspects and role in alcohol-induced liver injury
- CYP2E1 activity before and after weight loss in morbidly obese subjects with nonalcoholic fatty liver disease
- Developmental Expression of CYP2E1 in the Human Liver: Hypermethylation Control of Gene Expression During the Neonatal Period
- Role of CYP2E1 in thioacetamide-induced mouse hepatotoxicity
- The alcohol-inducible form of cytochrome P450 (CYP2E1): role in toxicology and regulation of expression
- Protection against acetaminophen toxicity in CYP1A2 and CYP2E1 double-null mice
- The impact of CYP2E1 on the development of alcoholic liver disease as studied in a transgenic mouse model
- Oxidative stress mediated toxicity exerted by ethanol-inducible CYP2E1
- Hepatocyte CYP2E1 overexpression and steatohepatitis lead to impaired hepatic insulin signaling
- Induction of CYP2E1 in liver, kidney, brain and intestine during chronic ethanol administration and withdrawal: evidence that CYP2E1 possesses a rapid phase half …
- Development and properties of HepG2 cells that constitutively express CYP2E1
- Differential effects of CYP2E1 status on the metabolic activation of the colon carcinogens azoxymethane and methylazoxymethanol
- CYP2E1 genotype and isoniazid-induced hepatotoxicity in patients treated for latent tuberculosis
- Human CYP2E1 mediates the formation of glycidamide from acrylamide
- Role of CYP2E1 in the epoxidation of acrylamide to glycidamide and formation of DNA and hemoglobin adducts
- CYP2E1-mediated mechanism of anti-genotoxicity of the broccoli constituent sulforaphane
- Brain CYP2E1 is induced by nicotine and ethanol in rat and is higher in smokers and alcoholics
- Iron and CYP2E1-dependent oxidative stress and toxicity
- Genetic polymorphisms of NAT2 and CYP2E1 associated with antituberculosis drug-induced hepatotoxicity in Korean patients with pulmonary tuberculosis
- Role of CYP2E1 in ethanol-induced oxidant stress, fatty liver and hepatotoxicity
- Biotransformation of caffeine, paraxanthine, theobromine and theophylline by cDNA-expressed human CYP1A2 and CYP2E1.
- Diallylsulfide and allylmethylsulfide are uniquely effective among organosulfur compounds in inhibiting CYP2E1 protein in animal models
- CYP2E1‐mediated oxidative stress induces collagen type I expression in rat hepatic stellate cells
- In vivo and in vitro characterization of CYP2E1 activity in Japanese and Caucasians.
- CYP2E1-dependent toxicity and up-regulation of antioxidant genes
- Metabolic activation of dacarbazine by human cytochromes P450: the role of CYP1A1, CYP1A2, and CYP2E1
- Polymorphisms in GSTT1, GSTZ1, and CYP2E1, Disinfection By-products, and Risk of Bladder Cancer in Spain
- Potentiation of thioacetamide liver injury in diabetic rats is due to induced CYP2E1
- Mechanisms of down-regulation of CYP2E1 expression by inflammatory cytokines in rat hepatoma cells
- Absence of acrylamide-induced genotoxicity in CYP2E1-null mice: evidence consistent with a glycidamide-mediated effect
- Advances in the interpretation and prediction of CYP2E1 metabolism from a biochemical perspective
- Role of NQO1, MPO and CYP2E1 genetic polymorphisms in the susceptibility to childhood acute lymphoblastic leukemia
- Cytochrome P450IIE1 (CYP2E1) is induced by skatole and this induction is blocked by androstenone in isolated pig hepatocytes
- Association of CYP2E1 gene polymorphism with predisposition to cancer development
- CYP2E1 substrate inhibition: Mechanistic interpretation through an effector site for monocyclic compounds
- Transcriptional control of the rat hepatic CYP2E1 gene
- Transcriptional control of CYP2E1 in the perivenous liver region and during starvation
- Mechanism-based inactivation of human CYP2E1 by diethyldithocarbamate
- Nrf2 and antioxidant defense against CYP2E1 toxicity
- Acetaldehyde as well as ethanol is metabolized by human CYP2E1
- NAT2 and CYP2E1 polymorphisms and susceptibility to first-line anti-tuberculosis drug-induced hepatitis
- Associations of CYP1A1, GSTM1, and CYP2E1 Polymorphisms with Lung Cancer Suggest Cell Type Specificities to Tobacco Carcinogens
- Pharmacokinetic consequences of induction of CYP2E1 by ligand stabilization
- Activity of CYP2E1 and CYP3A enzymes in adults with moderate alcohol consumption: a comparison with nonalcoholics
- Loss of CYP2E1 and CYP1A2 activity as a function of acetaminophen dose: relation to toxicity
- Acetone catabolism by cytochrome P450 2E1: studies with CYP2E1-null mice
- Genetic polymorphisms of CYP2E1, GSTM1, and GSTT1; environmental factors and risk of oral cancer.
- Regulation of CYP2E1 by ethanol and palmitic acid and CYP4A11 by clofibrate in primary cultures of human hepatocytes
- Gadolinium chloride blocks alcohol-dependent liver toxicity in rats treated chronically with intragastric alcohol despite the induction of CYP2E1
- Serum deprivation-induced HepG2 cell death is potentiated by CYP2E1
- CYP2E1 enhances ethanol-induced lipid accumulation but impairs autophaghy in HepG2 E47 cells
- Effects of rifampin on CYP2E1-dependent hepatotoxicity of isoniazid in rats
- CYP2E1 activity in patients with alcoholic liver disease
- Mitochondrial CYP2E1 is sufficient to mediate oxidative stress and cytotoxicity induced by ethanol and acetaminophen
- CYP2E1-dependent oxidative stress and toxicity: role in ethanol-induced liver injury
- Lipid peroxidation, CYP2E1 and arachidonic acid metabolism in alcoholic liver disease in rats
- CYP2E1-mediated modulation of valproic acid-induced hepatocytotoxicity
- Genetic Polymorphisms of CYP2E1 and Risk of Colorectal Cancer: The Fukuoka Colorectal Cancer Study
- Genetic polymorphism of GSTM1, CYP2E1 and CYP2D6 in Egyptian bladder cancer patients
- Cytochrome P450 2E1 (CYP2E1) is essential for acrylonitrile metabolism to cyanide: comparative studies using CYP2E1-null and wild-type mice
- Inhibition of CYP3A, CYP1A and CYP2E1 activities by resveratrol and other non volatile red wine components
- Expression of CYP2E1 during human fetal development: methylation of the CYP2E1 gene in human fetal and adult liver samples
- CYP2E1 overexpression in HepG2 cells induces glutathione synthesis by transcriptional activation of γ-glutamylcysteine synthetase
- Genetic polymorphisms of NAT2, CYP2E1 and GST enzymes and the occurrence of antituberculosis drug-induced hepatitis in Brazilian TB patients
- Genotype and allele frequencies of polymorphic CYP2E1 in the Turkish population
- The FANCG Fanconi anemia protein interacts with CYP2E1: possible role in protection against oxidative DNA damage
- Ethanol induction of CYP2A5: permissive role for CYP2E1
- Allylnitrile metabolism by CYP2E1 and other CYPs leads to distinct lethal and vestibulotoxic effects in the mouse
- CYP2E1 and catalase influence ethanol sensitivity in the central nervous system
- Acetaldehyde as a substrate for ethanol-inducible cytochrome P450 (CYP2E1)
- Cytochrome P450 2E1 (CYP2E1) is the principal enzyme responsible for urethane metabolism: comparative studies using CYP2E1-null and wild-type mice
- CYP1A1, CYP2E1 and GSTM1 genetic polymorphisms. The effect of single and combined genotypes on lung cancer susceptibility in Chilean people
- Red Meat Intake, CYP2E1 Genetic Polymorphisms, and Colorectal Cancer Risk
- Molecular mechanism of trichloroethylene-induced hepatotoxicity mediated by CYP2E1
- Comparison of germ cell mutagenicity in male CYP2E1-null and wild-type mice treated with acrylamide: evidence supporting a glycidamide-mediated effect
- Low doses of nicotine and ethanol induce CYP2E1 and chlorzoxazone metabolism in rat liver
- Role of CYP3A and CYP2E1 in alcohol-mediated increases in acetaminophen hepatotoxicity: comparison of wild-type and CYP2E1 (–/–) mice
- Insulin effects on CYP2E1, 2B, 3A, and 4A expression in primary cultured rat hepatocytes
- Overexpression of CYP2E1 in mitochondria sensitizes HepG2 cells to the toxicity caused by depletion of glutathione
- Induction of catalase, alpha, and microsomal glutathione S‐transferase in CYP2E1 overexpressing HepG2 cells and protection against short‐term oxidative stress
- Tissue-specific expression and methylation of the human CYP2E1 gene
- Evaluation of caffeine as a test drug for CYP1A2, NAT2 and CYP2E1 phenotyping in man by in vivo versus in vitro correlations.
- Induction and recovery time course of rat brain CYP2E1 after nicotine treatment
- Histone modification-mediated CYP2E1 gene expression and apoptosis of HepG2 cells
- Genetic variations of NAT2 and CYP2E1 and isoniazid hepatotoxicity in a diverse population
- Association between CYP2E1 genetic polymorphisms and lung cancer risk: a meta-analysis
- Expression, catalytic activity, and inducibility of cytochrome P450 2E1 (CYP2E1) in the rat central nervous system
- Genetic polymorphisms in GSTM1,-P1,-T1, and CYP2E1 and the risk of adult brain tumors
- The human CYP2E1 gene and lung cancer: DraI and RsaI restriction fragment length polymorphisms in a Finish study population
- Taurine protects acetaminophen-induced oxidative damage in mice kidney through APAP urinary excretion and CYP2E1 inactivation
- Synergistic toxicity of iron and arachidonic acid in HepG2 cells overexpressing CYP2E1
- Post-transcriptional regulation of rat CYP2E1 expression: role of CYP2E1 mRNA untranslated regions in control of translational efficiency and message stability
- CYP2E1* 1D regulatory polymorphism: association with alcohol and nicotine dependence
- Ethanol‐mediated carcinogenesis in the human esophagus implicates CYP2E1 induction and the generation of carcinogenic DNA‐lesions
- Role of alcohol and genetic polymorphisms of CYP2E1 and ALDH2 in breast cancer development
- Identification of novel toxicity-associated metabolites by metabolomics and mass isotopomer analysis of acetaminophen metabolism in wild-type and CYP2E1 …
- Bimodal targeting of microsomal CYP2E1 to mitochondria through activation of an N-terminal chimeric signal by cAMP-mediated phosphorylation
- Allele and genotype frequencies of polymorphic cytochromes P450 (CYP2C9, CYP2C19, CYP2E1) and dihydropyrimidine dehydrogenase (DPYD) in the Egyptian …
- Role of CYP2D6, CYP1A1, CYP2E1, GSTT1, and GSTM1 genes in the susceptibility to acute leukemias
- Inhibition of chlorzoxazone metabolism, a clinical probe for CYP2E1, by a single ingestion of watercress
- Lipopolysaccharide-induced liver injury in rats treated with the CYP2E1 inducer pyrazole
- Elucidation of CYP2E1 5′ regulatory RsaI/Pstl allelic variants and their role in risk for oral cancer
- The role of CYP2E1 and 2B1 in metabolic activation of benzene derivatives
- The investigation into CYP2E1 in relation to the level of response to alcohol through a combination of linkage and association analysis
- Analysis of differential substrate selectivities of CYP2B6 and CYP2E1 by site-directed mutagenesis and molecular modeling
- Construction and assessment of models of CYP2E1: predictions of metabolism from docking, molecular dynamics, and density functional theoretical calculations
- Acetoacetate induces CYP2E1 protein and suppresses CYP2E1 mRNA in primary cultured rat hepatocytes
- The RsaI polymorphism of CYP2E1 and susceptibility to alcoholic liver disease in Caucasians: effect on age of presentation and dependence on alcohol …
- Effect of ethanol on cytochrome P450 2E1 (CYP2E1), lipid peroxidation, and serum protein adduct formation in relation to liver pathology pathogenesis
- Metabolism of benzene in human liver microsomes: individual variations in relation to CYP2E1 expression
- Phyllanthus urinaria extract attenuates acetaminophen induced hepatotoxicity: involvement of cytochrome P450 CYP2E1
- Constitutive and inducible expression of hepatic CYP2E1 in leptin-deficient ob/ob mice
- CYP2E1 and NQO1 genotypes, smoking and bladder cancer
- Study of polymorphisms in the CYP2E1 gene in patients with alcoholic pancreatitis
- The GST T1 and CYP2E1 genotypes are possible factors causing vinyl chloride induced abnormal liver function
- Role of the Liver-Enriched Transcription Factor HNF-1α in Expression of the CYP2E1 Gene
- Ontogeny of hepatic CYP1A2 and CYP2E1 expression in rat
- Metabolism of dapsone to its hydroxylamine by CYP2E1 in vitro and in vivo
- Expression of CYP2E1 increases oxidative stress and induces apoptosis of cardiomyocytes in transgenic mice
- Cytochrome P450 CYP2E1, but not nicotinamide adenine dinucleotide phosphate oxidase, is required for ethanol‐induced oxidative DNA damage in rodent liver
- The effect of ethanol-induced CYP2E1 on proteasome activity: the role of 4-hydroxynonenal
- Regional and cellular distribution of CYP2E1 in monkey brain and its induction by chronic nicotine
- Association of genetic polymorphisms in CYP2E1, MPO, NQO1, GSTM1, and GSTT1 genes with benzene poisoning.
- Variation in induction of human placental CYP2E1: possible role in susceptibility to fetal alcohol syndrome?
- Genetic polymorphisms of CYP1A1, CYP2E1, GSTM1, and GSTT1 associated with head and neck cancer
- Rapid changes in cytochrome P4502E1 (CYP2E1) activity and other P450 isozymes following ethanol withdrawal in rats
- Risk assessment: toxicity from chemical exposure resulting from enhanced expression of CYP2E1
- … for the Expression of Recombinant Human Cytochrome P450s inEscherichia coliUsing Bacterial Signal Peptides: Expression of CYP3A4, CYP2A6, and CYP2E1
- Relationship between mRNA levels quantified by reverse transcription-competitive PCR and metabolic activity of CYP3A4 and CYP2E1 in human liver
- Genetic polymorphism analysis of cytochrome P4502E1 (CYP2E1) in Chinese Han populations from four different geographic areas of Mainland China
- Transgenic alfalfa plants co-expressing glutathione S-transferase (GST) and human CYP2E1 show enhanced resistance to mixed contaminates of heavy metals and …
- Characterization of cytochrome P4502E1 turnover in transfected HepG2 cells expressing human CYP2E1
- Polymorphism in cytochrome P450 CYP2D6, CYP1A1, CYP2E1 and glutathione S-transferase, GSTM1, GSTM3, GSTT1 and susceptibility to tobacco-related cancers …
- Construction of a CYP2E1-template system for prediction of the metabolism on both site and preference order
- Trade herbal products and induction of CYP2C19 and CYP2E1 in cultured human hepatocytes
- Removal of glutathione produces apoptosis and necrosis in HepG2 cells overexpressing CYP2E1
- CYP2E1 is preferentially expressed in Clara cells of murine lung: localization by in situ hybridization and immunohistochemical methods.
- NQO1, MPO, CYP2E1, GSTT1 and GSTM1 polymorphisms and biological effects of benzene exposure—a literature review
- Spectrophotometric Analysis of Human CYP2E1-Catalyzed p-Nitrophenol Hydroxylation
- An interaction between the cytochrome P450 probe substrates chlorzoxazone (CYP2E1) and midazolam (CYP3A)
- Heteromeric complex formation between CYP2E1 and CYP1A2: evidence for the involvement of electrostatic interactions
- CYP2E1 induced by ethanol causes oxidative stress, proteasome inhibition and cytokeratin aggresome (Mallory body-like) formation
- Pharmacokinetics of theophylline in diabetes mellitus rats: induction of CYP1A2 and CYP2E1 on 1, 3-dimethyluric acid formation
- Inhibition of CYP2E1 Reverses CD4+ T-Cell Alterations in Trichloroethylene-Treated MRL+/+ Mice
- Genetic polymorphisms of CYP2D6, CYP1A1 and CYP2E1 in the South-Amerindian population of Chile.
- Amelioration of oxidative stress by dandelion extract through CYP2E1 suppression against acute liver injury induced by carbon tetrachloride in sprague‐dawley rats
- CYP2E1-dependent hepatotoxicity and oxidative damage after ethanol administration in human primary hepatocytes
- St. John’s wort extract induces CYP3A and CYP2E1 in the Swiss Webster mouse
- Effect of antifungal drugs on cytochrome P450 (CYP) 1A2, CYP2D6, and CYP2E1 activities in human liver microsomes
- Inhibition of CYP2E1 catalytic activity in vitro by S-adenosyl-L-methionine
- Combined analysis of germline polymorphisms of p53, GSTM1, GSTT1, CYP1A1, and CYP2E1: relation to the incidence rate of cervical carcinoma
- Immunohistochemical demonstration of the expression of CYP2E1 in human breast tumour and non-tumour tissues
- Major tanshinones of Danshen (Salvia miltiorrhiza) exhibit different modes of inhibition on human CYP1A2, CYP2C9, CYP2E1 and CYP3A4 activities in vitro
- Genetic polymorphisms in cytochrome P450 (CYP) 1A1, CYP1A2, CYP2E1, glutathione S-transferase (GST) M1 and GSTT1 and susceptibility to prostate cancer in the …
- Modeling interchild differences in pharmacokinetics on the basis of subject-specific data on physiology and hepatic CYP2E1 levels: a case study with toluene
- A significantly joint effect between arsenic and occupational exposures and risk genotypes/diplotypes of CYP2E1, GSTO1 and GSTO2 on risk of urothelial carcinoma
- CYP2E1 regulation by benzene and other small organic chemicals in rat liver and peripheral lymphocytes
- Metabolic oxidation and toxification of N-methylformamide catalyzed by the cytochrome P450 isoenzyme CYP2E1.
- Differential Modulation of CYP2E1 Activity by CAMP-Dependent Protein Kinase upon Ser129Replacement
- Kinetic characterization of CYP2E1 inhibition in vivo and in vitro by the chloroethylenes
- Translational activation of ethanol-inducible cytochrome P450 (CYP2E1) by isoniazid
- Effects of occupation, lifestyle and genetic polymorphisms of CYP1A1, CYP2E1, GSTM1 and GSTT1 on urinary 1-hydroxypyrene and 2-naphthol concentrations
- Distribution and differential induction of CYP2E1 by ethanol and acetone in the mesocorticolimbic system of rat
- Identification and characterization of a mitochondrial targeting signal in rat cytochrome P450 2E1 (CYP2E1)
- Investigation of xenobiotics metabolism, genotoxicity, and carcinogenicity using CYP2E1-/-mice
- CYP2E1 overexpression alters hepatocyte death from menadione and fatty acids by activation of ERK1/2 signaling
- Analysis of CYP2E1 polymorphism for the determination of genetic susceptibility to gastric cancer in Koreans
- Obesity-induced increase of CYP2E1 activity and its effect on disposition kinetics of chlorzoxazone in Zucker rats
- Lung cancer risk in relation to the CYP2E1 Rsa I genetic polymorphism among African-Americans and Caucasians in Los Angeles County.
- Polymorphism in CYP1A1 and CYP2E1 genes and susceptibility to leukoplakia in Indian tobacco users
- Early Alcoholic Liver Injury: Formation of Protein Adducts with Acetaldehyde and Lipid Peroxidation Products, and Expression of CYP2E1 AND CYP3A
- Frequencies of genotypes and alleles of the functional SNPs in CYP2C19 and CYP2E1 in mainland Chinese Kazakh, Uygur and Han populations
- CYP1A1 CYP2E1 and GSTM1 polymorphisms are not associated with susceptibility to squamous‐cell carcinoma of the esophagus
- Influence of CYP1A1, CYP2E1, GSTM3 and NAT2 genetic polymorphisms in oral cancer susceptibility: results from a case-control study in Rio de Janeiro
- Effects of cytochrome P450 (CYP) 2A6 gene deletion and CYP2E1 genotypes on gastric adenocarcinoma
- Involvement of CYP2E1 as a low-affinity enzyme in phenacetin O-deethylation in human liver microsomes
- Adenovirus-mediated expression of CYP2E1 produces liver toxicity in mice
- Metabolic activation of N-alkylnitrosamines in genetically engineered Salmonella typhimurium expressing CYP2E1 or CYP2A6 together with human NADPH …
- Combined metadoxine and garlic oil treatment efficaciously abrogates alcoholic steatosis and CYP2E1 induction in rat liver with restoration of AMPK activity
- A Novel Polymorphism rs1329149 of CYP2E1 and a Known Polymorphism rs671 of ALDH2 of Alcohol Metabolizing Enzymes Are Associated with Colorectal Cancer …
- Association of CYP2E1 and NAT2 gene polymorphisms with chronic obstructive pulmonary disease
- CYP2A6 and CYP2E1 polymorphisms in a Brazilian population living in Rio de Janeiro
- Microsomal ethanol oxidizing system: transcriptional and posttranscriptional regulation of cytochrome P450, CYP2E1.
- Mitochondrial dysfunction by γ-irradiation accompanies the induction of cytochrome P450 2E1 (CYP2E1) in rat liver
- Role of CYP2E1 genotypes in susceptibility to colorectal cancer in the Kashmiri population
- Acetaldehyde generating enzyme systems: roles of alcohol dehydrogenase, CYP2E1 and catalase, and speculations on the role of other enzymes and processes
- Inactivation of stress protein p8 increases murine carbon tetrachloride hepatotoxicity via preserved CYP2E1 activity
- Lycopene attenuates alcoholic apoptosis in HepG2 cells expressing CYP2E1
- CYP2E1 degradation by in vitro reconstituted systems: role of the molecular chaperone hsp90
- CYP1A1, CYP2D6, CYP2E1, NAT2, GSTM1 and GSTT1 polymorphisms or their combinations are associated with the increased risk of the laryngeal squamous cell …
- Induction of nicotine-metabolizing CYP2B1 by ethanol and ethanol-metabolizing CYP2E1 by nicotine: summary and implications
- Expression of CYP2E1 in human nasopharynx and its metabolic effect in vitro
- Role of p38 MAPK in CYP2E1-dependent arachidonic acid toxicity
- Genetic Polymorphisms of ADH1C and CYP2E1 and Risk of Oral Squamous Cell Carcinoma
- Ethnic susceptibility to lung cancer: differences in CYP2E1, CYP1A1 and GSTM1 genetic polymorphisms between French Caucasian and Chilean populations
- CYP2E1 expression in human lymphocytes from various ethnic populations
- Association between CYP2E1 polymorphisms and susceptibility to prostate cancer
- CYP2E1 potentiation of LPS and TNFα-induced hepatotoxicity by mechanisms involving enhanced oxidative and nitrosative stress, activation of MAP kinases …
- CYP2E1-dependent benzene toxicity: the role of extrahepatic benzene metabolism
- The effects of alcohol and diallyl sulphide on CYP2E1 activity in humans: a phenotyping study using chlorzoxazone
- Distribution of ADH1B, ALDH2, CYP2E1∗ 6, and CYP2E1∗ 7B genotypes in Turkish population
- The effect of CYP2E1-dependent oxidant stress on activity of proteasomes in HepG2 cells
- Genetic polymorphism of CYP2E1, ADH2, and ALDH2 in Mexican-Americans
- Effect of ALDH2 and CYP2E1 Gene Polymorphisms on Drinking Behavior and Alcoholic Liver Disease in Japanese Male Workers
- Tandem Repeat Polymorphism of the CYP2E1 Gene: An Association Study With Esophageal Cancer and Lung Cancer
- The pig CYP2E1 promoter is activated by COUP-TF1 and HNF-1 and is inhibited by androstenone
- CYP1A2* 1C, CYP2E1* 5B, and GSTM1 polymorphisms are predictors of risk and poor outcome in head and neck squamous cell carcinoma patients
- Polymorphisms in glutathione S‐transferases GSTM1, GSTT1 and GSTP1 and cytochromes P450 CYP2E1 and CYP1A1 and susceptibility to cirrhosis or …
- DNA damage and cytotoxicity in pancreatic β-cells expressing human CYP2E1
- Cytochrome P4502E1 (CYP2E1) expression in peripheral blood lymphocytes: evaluation in hepatitis C and diabetes
- Molecular modelling of human CYP2E1 by homology with the CYP102 haemoprotein domain: investigation of the interactions of substrates and inhibitors within the …
- Relationship in healthy subjects between CYP2E1 genetic polymorphisms and the 6-hydroxyIation of chlorzoxazone: a putative measure of CYP2E1 activity
- Pharmacokinetics of chlorzoxazone in rats with diabetes: induction of CYP2E1 on 6-hydroxychlorzoxazone formation
- Significance of genetic polymorphisms at multiple loci of CYP2E1 in the risk of development of childhood acute lymphoblastic leukemia
- The effect of isoniazid on CYP2E1-and CYP4A-mediated hydroxylation of arachidonic acid in the rat liver and kidney
- Immunohistochemical study of CYP2E1 in hepatocellular carcinoma carcinogenesis: examination with newly prepared anti-human CYP2E1 antibody
- Human hepatocytes are protected from ethanol-induced cytotoxicity by DADS via CYP2E1 inhibition
- Genetic polymorphism of the CYP1A1, CYP2E1, GSTM1 and GSTT1 genes and lung cancer susceptibility in a north Indian population
- Cytochrome CYP2E1 phenotyping and genotyping in the evaluation of health risks from exposure to polluted environments
- Growth retardation of fetal rats exposed to nicotine in utero: Possible involvement of CYP1A1, CYP2E1, and P‐glycoprotein
- Association of GSTM1, CYP1A1 and CYP2E1 genetic polymorphisms with susceptibility to lung adenocarcinoma: A case‐control study in Chinese population
- Induction of hepatic CYP2E1 by a subtoxic dose of acetaminophen in rats: increase in dichloromethane metabolism and carboxyhemoglobin elevation
- CYP2E1 Rsa I polymorphism impacts on risk of colorectal cancer association with smoking and alcohol drinking
- The impact of CYP2E1 genetic variability on risk assessment of VOC mixtures
- Protective effects of goldenseal (Hydrastis canadensis L.) on acetaminophen-induced hepatotoxicity through inhibition of CYP2E1 in rats
- Rat hepatic CYP2E1 is induced by very low nicotine doses: an investigation of induction, time course, dose response, and mechanism
- CYP2A6/2A7 and CYP2E1 expression in human oesophageal mucosa: regional and inter-individual variation in expression and relevance to nitrosamine metabolism
- Global Analysis of Protein− Protein Interactions Reveals Multiple CYP2E1− Reductase Complexes
- Differential role of CYP2E1 binders and isoniazid on CYP2E1 protein modification in NADPH-dependent microsomal oxidative reactions: free radical scavenging …
- Antioxidant and pro-oxidant effects of a manganese porphyrin complex against CYP2E1-dependent toxicity
- Polymorphisms of CYP1a1, CYP2E1, GSTM1, GSTT1, and TP53 genes in Amerindians
- CYP1A1, CYP2E1, GSTM1, GSTT1, EPHX1 exons 3 and 4, and NAT2 polymorphisms, smoking, consumption of alcohol and fruit and vegetables and risk of head and …
- CYP2E1 Rsa I/Pst I polymorphism is associated with lung cancer risk among Asians
- The role of CYP2A and CYP2E1 in the metabolism of 3-methylindole in primary cultured porcine hepatocytes
- Homology modelling of human CYP2E1 based on the CYP2C5 crystal structure: investigation of enzyme–substrate and enzyme–inhibitor interactions
- Studies on interindividual variations of CYP2E1 using chlorzoxazone as an in vivo probe
- A Case–control and a family-based association study revealing an association between CYP2E1 polymorphisms and nasopharyngeal carcinoma risk …
- Functional polymorphism in porcine CYP2E1 gene: Its association with skatole levels
- Identification of CYP2E1 in marmoset monkey
- Effects of diabetes on rabbit kidney and lung CYP2E1 and CYP2B4 expression and drug metabolism and potentiation of carcinogenic activity of N …
- Does CYP2E1 play a major role in the aggravation of isoniazid toxicity by rifampicin in human hepatocytes?
- Relationship between genetic polymorphisms of metabolizing enzymes CYP2E1, GSTM1 and Kazakh’s esophageal squamous cell cancer in Xinjiang, China
- ADH2 and CYP2E1 genetic polymorphisms: risk factors for alcohol-related birth defects
- Renal and hepatic accumulation of cadmium and lead in the expression of CYP4F2 and CYP2E1
- Ageing is associated with increased expression but decreased activity of CYP2E1 in male Wistar rats
- Metallothionein 2A induction by zinc protects HEPG2 cells against CYP2E1-dependent toxicity
- Porcine CYP2A19, CYP2E1 and CYP1A2 forms are responsible for skatole biotransformation in the reconstituted system
- Effect of cigarette smoke on hepatic and pulmonary cytochromes P450 in mouse: evidence for CYP2E1 induction in lung
- CYP2E1 and ALDH2 genotypes and alcohol dependence in Japanese
- Effect of fasting and obesity in humans on the 6‐hydroxylation of chlorzoxazone: a putative probe of CYP2E1 activity
- Benzene-induced genotoxicity in mice in vivo detected by the alkaline comet assay: reduction by CYP2E1 inhibition
- Adverse Birth Outcomes Associated with Maternal Smoking and Polymorphisms in the N-Nitrosamine-Metabolizing Enzyme Genes NQO1 and CYP2E1
- NADPH-dependent microsomal electron transfer increases degradation of CYP2E1 by the proteasome complex: role of reactive oxygen species
- Hypomethylation and hypoexpression of human CYP2E1 gene in lung tumors
- GSTT1 and CYP2E1 polymorphisms and trihalomethanes in drinking water: effect on childhood leukemia.
- Inhibition of CYP2E1 with natural agents may be a feasible strategy for minimizing the hepatotoxicity of ethanol
- A High Throughput Screening Assay to Screen for CYP2E1 Metabolism and Inhibition Using a Fluorogenic Vivid® P450 Substrate
- Ethanol and arachidonic acid produce toxicity in hepatocytes from pyrazole-treated rats with high levels of CYP2E1
- GSTT1, GSTM1 and CYP2E1 genetic polymorphisms in gastric cancer and chronic gastritis in a Brazilian population
- A temporal study on the histopathological, biochemical and molecular responses of CCl4-induced hepatotoxicity in CYP2E1-null mice
- Effects of Ganoderma lucidum polysaccharide on CYP2E1, CYP1A2 and CYP3A activities in BCG-immune hepatic injury in rats
- Expression of CYP2E1 in Human Lung and Kidney during Development and in Full‐Term Placenta: A Differential Methylation of the Gene is Involved in the …
- Comparative metabolism and disposition of trichloroethylene in CYP2E1–/–and wild-type mice
- Inhibition of cytochrome P450 enzymes participating in p-nitrophenol hydroxylation by drugs known as CYP2E1 inhibitors
- Chlorzoxazone as a single sample probe of hepatic CYP2E1 activity in humans
- Kupffer cell inactivation alleviates ethanol-induced steatosis and CYP2E1 induction but not inflammatory responses in rat liver
- Protective effects of emodin and chrysophanol isolated from marine fungus Aspergillus sp. on ethanol-induced toxicity in HepG2/CYP2E1 cells
- Association of combined CYP2E1 gene polymorphism with the risk for esophageal squamous cell carcinoma in Huai’an population, China
- Covalent immobilization of recombinant human cytochrome CYP2E1 and glucose-6-phosphate dehydrogenase in alumina membrane for drug screening applications
- Promoter function and the role of cytokines in the transcriptional regulation of rabbit CYP2E1 and CYP2E2
- Differential effects of diabetes on CYP2E1 and CYP2B4 proteins and associated drug metabolizing enzyme activities in rabbit liver
- … exposure to styrene: modulation of cytogenetic damage and levels of urinary metabolites of styrene by polymorphisms in genes CYP2E1, EPHX1, GSTM1, GSTT1 …
- Relationship between alcoholism and CYP2E1 C/D polymorphism
- Polymorphism of metabolizing genes and lung cancer histology: prevalence of CYP2E1 in adenocarcinoma
- Differential effects of dietary fatty acids on the regulation of CYP2E1 and protein kinase C in human hepatoma HepG2 cells
- Cytochrome P4502E1 (CYP2E1) genetic polymorphism in a case-control study of gastric cancer and liver disease.
- Lymphocyte cytochrome P450-CYP2E1 expression in human IDDM subjects
- Role of calcium and calcium-activated proteases in CYP2E1-dependent toxicity in HEPG2 cells
- Oxidative stress potentiated by diallylsulfide, a selective CYP2E1 inhibitor, in isoniazid toxic effect on rat primary hepatocytes
- Relationship between genetic polymorphisms of drug-metabolizing enzymes (CYP1A1, CYP2E1, GSTM1, and NAT2), drinking habits, histological subtypes, and p53 …
- The mode of cisplatin-induced cell death in CYP2E1-overexpressing HepG2 cells: modulation by ERK, ROS, glutathione, and thioredoxin
- Role of intracellular calcium and phospholipase A2 in arachidonic acid-induced toxicity in liver cells overexpressing CYP2E1
- Helicobacter pylori infection, but not genetic polymorphism of CYP2E1, is highly prevalent in gastric cancer patients younger than 40 years
- Role of CYP2E1 immunoglobulin G4 subclass antibodies and complement in pathogenesis of idiosyncratic drug-induced hepatitis
- A negative cooperativity mechanism of human CYP2E1 inferred from molecular dynamics simulations and free energy calculations
- Hormone controlled phosphorylation and degradation of CYP2B1 and CYP2E1 in isolated rat hepatocytes
- Effects of the ADH3, CYP2E1, and GSTP1 genetic polymorphisms on their expressions in Caucasian lung tissue
- Genetic polymorphism of the CYP2E1 gene and susceptibility to Parkinson’s disease in Taiwanese
- Transcription factor Nrf2 protects HepG2 cells against CYP2E1 plus arachidonic acid-dependent toxicity
- Differential in vivo effects of α‐naphthoflavone and β‐naphthoflavone on CYP1A1 and CYP2E1 in rat liver, lung, heart, and kidney
- cDNA sequence, deduced amino acid sequence, predicted gene structure and chemical regulation of mouse CYP2E1
- … and CYP2E1 and N‐terminal truncated CYP1A1 proteins in Saccharomyces cerevisiae − role of protein kinase A in the mitochondrial targeting of CYP2E1
- CYP2E1 PstI/RsaI polymorphism and colorectal cancer risk: a meta-analysis
- Lipopolysaccharide induces CYP2E1 in astrocytes through MAP kinase kinase-3 and C/EBPβ and-δ
- Inhibition of urethane-induced genotoxicity and cell proliferation in CYP2E1-null mice
- Depletion of cytosolic or mitochondrial thioredoxin increases CYP2E1-induced oxidative stress via an ASK-1–JNK1 pathway in HepG2 cells
- Theoretical study of the mechanism of acetaldehyde hydroxylation by compound I of CYP2E1
- Molecular modelling of CYP2E1 enzymes from rat, mouse and man: an explanation for species differences in butadiene metabolism and potential carcinogenicity, and …
- The molecular mechanism regulating 24‐hour rhythm of CYP2E1 expression in the mouse liver
- Ethanol‐related cytotoxicity catalyzed by CYP2E1‐dependent generation of reactive oxygen intermediates in transduced HepG2 cells
- Validation of the (ω-l)-hydroxylation of lauric acid as an in vitro substrate probe for human liver CYP2E1
- The ADH3* 2 and CYP2E1 c2 alleles increase the risk of alcoholism in Mexican American men
- Interindividual variability of chlorzoxazone 6‐hydroxylation in men and women and its relationship to CYP2E1 genetic polymorphisms
- Impact of CYP2E1 genotype in renal cell and urothelial cancer patients
- Docosahexaenoic acid induces apoptosis in CYP2E1-containing HepG2 cells by activating the c-Jun N-terminal protein kinase related mitochondrial damage
- Decreased protein and mRNA expression of ER stress proteins GRP78 and GRP94 in HepG2 cells over-expressing CYP2E1
- Role of CYP2E1 activity in endoplasmic reticulum ubiquitination, proteasome association, and the unfolded protein response
- Sodium salicylate increases CYP2E1 levels and enhances arachidonic acid toxicity in HepG2 cells and cultured rat hepatocytes
- Distribution of cytochrome CYP2E1 in murine liver after ethanol and acetone administration
- Contribution of CYP2E1 to N-methyl-2-pyrrolidone metabolism
- Induction and regulation of CYP2E1 in murine liver after acute and chronic acetone administration.
- Phenobarbital induces monkey brain CYP2E1 protein but not hepatic CYP2E1, in vitro or in vivo chlorzoxazone metabolism
- Ethanol-induced oxidative DNA damage and CYP2E1 expression in liver tissue of Aldh2 knockout mice
- Modification of CYP2E1 and CYP3A4 activities in haemoglobin E-beta thalassemia patients
- Changes of CYP2E1 activity in diabetic rat model
- Use of molecular simulation for mapping conformational CYP2E1 epitopes
- Ethanol enhanced the genotoxicity of acrylamide in human, metabolically competent HepG2 cells by CYP2E1 induction and glutathione depletion
- Global patterns of variation in allele and haplotype frequencies and linkage disequilibrium across the CYP2E1 gene
- The cytochrome P-450 isoenzyme CYP2E1 in the biological processing of industrial chemicals: consequences for occupational and environmental medicine
- Differential metabolism of acrylonitrile to cyanide is responsible for the greater sensitivity of male vs female mice: role of CYP2E1 and epoxide hydrolases
- CYP2E1 expression in bone marrow and its intra-and interspecies variability: approaches for a more reliable extrapolation from one species to another in the risk …
- Role of CYP2E1 and saturation kinetics in the bioactivation of thioacetamide: Effects of diet restriction and phenobarbital
- Stable expression of human CYP2E1 in Chinese hamster cells: high sensitivity to N, N-dimethylnitrosamine in cytotoxicity testing
- Immunological detection of CYP2E1 in fresh rat lymphocytes and its pretranslational induction by fasting
- The induction of the human hepatic CYP2E1 gene by interleukin 4 is transcriptional and regulated by protein kinase C
- Comparison of genetic polymorphisms of CYP2E1, ADH2, and ALDH2 genes involved in alcohol metabolism in Koreans and four other ethnic groups
- Identification of inhibitory component in cinnamon—o-methoxycinnamaldehyde inhibits cyp1a2 and CYP2E1—
- Hepatic and pulmonary microsomal benzene metabolism in CYP2E1 knockout mice
- … in urea in conjunction with L-arginine metabolism in the liver leads to induction of cytochrome P450 2E1 (CYP2E1): The role of urea in CYP2E1 induction by acute …
- Effect of chronic disulfiram administration on the activities of CYP1A2, CYP2C19, CYP2D6, CYP2E1, and N‐acetyltransferase in healthy human subjects
- Detection of auto-antibodies against cytochrome P4502E1 (CYP2E1) in chronic hepatitis C
- CYP2E1-catalyzed oxidation contributes to the sperm toxicity of 1-bromopropane in mice
- Protective effects of loquat (Eriobotrya japonica) leaves against ethanol-induced toxicity in HepG2 cells transfected with CYP2E1
- Transfected HepG2 cells for evaluation of catechin effects on alcohol-induced CYP2E1 cytotoxicity
- Safrole-DNA adducts in human peripheral blood—an association with areca quid chewing and CYP2E1 polymorphisms
- Increased bioaccumulation of urethane in CYP2E1-/-versus CYP2E1+/+ mice
- Spin trapping agents (Tempol and POBN) protect HepG2 cells overexpressing CYP2E1 against arachidonic acid toxicity
- Age-related changes in the protein and mRNA levels of CYP2E1 and CYP3A isoforms as well as in their hepatic activities in Wistar rats. What role for oxidative stress?
- Functional CYP2E1 is required for substantial in vivo formation of 2, 5-hexanedione from n-hexane in the mouse
- Metabolism of ethyl carbamate by pulmonary cytochrome P450 and carboxylesterase isozymes: involvement of CYP2E1 and hydrolase A
- Genetic Repeat Polymorphism in the Regulating Region of CYP2E1: Frequency and Relationship With Enzymatic Activity in Alcoholics
- … by allyl sulfides and phenethyl isothiocyanate of methyl-n-pentylnitrosamine depentylation by rat esophageal microsomes, human and rat CYP2E1, and Rat CYP2A3
- Effects of ALDH2, CYP1A1, and CYP2E1 genetic polymorphisms and smoking and drinking habits on toluene metabolism in humans
- Therapeutic hypothermia-induced pharmacokinetic alterations on CYP2E1 chlorzoxazone-mediated metabolism in a cardiac arrest rat model
- Investigation of bioactivation and toxicity of styrene in CYP2E1 transgenic cells
- Increased prooxidant production and enhanced susceptibility to glutathione depletion in HepG2 cells co‐expressing HCV core protein and CYP2E1
- Acute ethanol pretreatment increases FAS-mediated liver injury in mice: role of oxidative stress and CYP2E1-dependent and-independent pathways
- DNA repair XRCC1 Arg399Gln polymorphism alone, and in combination with CYP2E1 polymorphisms significantly contribute to the risk of development of childhood …
- Do Endogenous Volatile Organic Chemicals Measured in Breath Reflect and Maintain CYP2E1 Levelsin Vivo?
- XRCC1 and CYP2E1 Polymorphisms as Susceptibility Factors of Plasma Mutant p53 Protein and Anti-p53 Antibody Expression in Vinyl Chloride …
- Evidence of association of the CYP2E1 genetic polymorphism with micronuclei frequency in human peripheral blood
- Human variability for metabolic pathways with limited data (CYP2A6, CYP2C9, CYP2E1, ADH, esterases, glycine and sulphate conjugation)
- CYP2E1 mRNA expression, genetic polymorphisms in peripheral blood lymphocytes and liver abnormalities in Chinese VCM-exposed workers
- Role of CYP1A2 and CYP2E1 in the pentoxifylline ciprofloxacin drug interaction
- Comparison of the susceptibility of wild-type and CYP2E1 knockout mice to the hepatotoxic and pneumotoxic effects of styrene and styrene oxide
- High inducibility of mouse renal CYP2E1 gene by tobacco smoke and its possible effect on DNA single strand breaks
- Effect of the CYP2E1 genotype on vinyl chloride monomer-induced liver fibrosis among polyvinyl chloride workers
- Gene–environmental interactions between alcohol-drinking behavior and ALDH2 and CYP2E1 polymorphisms and their impact on micronuclei frequency in human …
- Duration of cytochrome P-450 2E1 (CYP2E1) inhibition and estimation of functional CYP2E1 enzyme half-life after single-dose disulfiram administration in humans
- Induction of CYP2E1 activity in liver transplant patients as measured by chlorzoxazone 6‐hydroxylation
- Diallyl sulfide inhibition of CYP2E1 does not rescue diabetic rats from thioacetamide-induced mortality
- Pulmonary bioactivation of trichloroethylene to chloral hydrate: relative contributions of CYP2E1, CYP2F, and CYP2B1
- The 2006 bernard B. Brodie award lecture: CYP2E1
- Differential induction of ethanol-metabolizing CYP2E1 and nicotine-metabolizing CYP2B1/2 in rat liver by chronic nicotine treatment and voluntary ethanol intake
- Effects of genetic polymorphisms of CYP1A1, CYP2E1, GSTM1, and GSTT1 on the urinary levels of 1-hydroxypyrene and 2-naphthol in aircraft maintenance workers
- Genetic polymorphisms of CYP2E1 and GSTM1 in a Thai population
- DLPC attenuates alcohol-induced cytotoxicity in HepG2 cells expressing CYP2E1
- Role of polymorphic CYP2E1 and CYP2D6 genes in NNK-induced chromosome aberrations in cultured human lymphocytes
- A comparison of substrate dynamics in human CYP2E1 and CYP2A6
- S-adenosyl-L-methionine attenuates hepatotoxicity induced by agonistic Jo2 Fas antibody following CYP2E1 induction in mice
- Expression of CYP2E1 by human monocyte‐derived macrophages
- CYP2E1 polymorphisms and gene–environment interactions in the risk of upper aerodigestive tract cancers among Indians
- NAT2, CYP2C9, CYP2C19, and CYP2E1 genetic polymorphisms in anti-TB drug-induced maculopapular eruption
- Role of CYP2E1 in the pathogenesis of alcoholic liver disease: modifications by cAMP and ubiquitin-proteasome pathway
- Spectrophotometric analysis of human CYP2E1-catalyzed p-nitrophenol hydroxylation
- Cervical cancer and CYP2E1 polymorphisms: implications for molecular epidemiology
- Inactivation of hepatic CYP2E1 by an epoxide of diallyl sulfone
- Insertion polymorphism of CYP2E1 and urinary N-methylformamide after N, N-dimethylformamide exposure in Japanese workers
- Effect of exposure to benzo [a] pyrene on SODs, CYP1A1/1A2-and CYP2E1 immunopositive proteins in the blood clam Scapharca inaequivalvis
- Ethanol-mediated transplacental induction of CYP2E1 in fetal rat liver
- Breaking self-tolerance toward cytochrome P4502E1 (CYP2E1) in chronic hepatitis C: possible role for molecular mimicry
- Cytochrome P450 2E1 (CYP2E1)-dependent production of a 37-kDa acetaldehyde–protein adduct in the rat liver
- Ethanol intake and ethanol-induced locomotion and locomotor sensitization in CYP2E1 knockout mice
- Associations between CYP2E1 promoter polymorphisms and plasma 1, 3-dimethyluric acid/theophylline ratios
- Genotype and allele frequencies of polymorphic cytochromes P450 CYP1A2 and CYP2E1 in Mexicans
- CYP1A1, CYP2E1, GSTM1, GSTT1, GSTP1, and TP53 polymorphisms: do they indicate susceptibility to chronic obstructive pulmonary disease and non-small-cell …
- Effects of dietary fat composition on activities of the microsomal ethanol oxidizing system and ethanol‐inducible cytochrome P450 (CYP2E1) in the liver of rats …
- Use of the CYP2E1 genotype and phenotype for the biological monitoring of occupational exposure to styrene
- In vivo and in vitro characterization of chlorzoxazone metabolism and hepatic CYP2E1 levels in African Green monkeys: induction by chronic nicotine treatment
- Proteasome inhibition potentiates CYP2E1‐mediated toxicity in HepG2 cells
- Effect of CYP2E1 gene deletion in mice on expression of microsomal epoxide hydrolase in response to VCD exposure
- Adenovirus-mediated expression of Cu/Zn-or Mn-superoxide dismutase protects against CYP2E1-dependent toxicity
- CYP2E1 G1532C, NQO1 Pro187Ser, and CYP1B1 Val432Leu polymorphisms are not associated with risk of squamous cell carcinoma of the head and neck
- CYP2E1 active site residues in substrate recognition sequence 5 identified by photoaffinity labeling and homology modeling
- Malotilate, a hepatoprotectant, suppresses CYP2E1 expression in rats
- Role of mouse CYP2E1 in the O-hydroxylation of p-nitrophenol: comparison of activities in hepatic microsomes from CYP2E1 (-/-) and wild-type mice
- Pulsatile blood alcohol and CYP2E1 induction during chronic alcohol infusions in rats
- … dehydrogenase 2, cytochrome p450 2E1 for liver cancer risk in HCV antibody-positive japanese patients and the variations of CYP2E1 mRNA expression levels in the …
- Use of CYP2E1‐transfected human liver cell lines in elucidating the actions of ethanol
- In vivo CYP2E1 phenotyping as a new potential biomarker of occupational and experimental exposure to benzene
- Induction of DNA strand breaks and oxidative stress in HeLa cells by ethanol is dependent on CYP2E1 expression
- Genetic polymorphisms of the CYP2E1 gene do not contribute to oral cancer susceptibility in south Indians
- Phenotype distribution and gender-related differences of CYP2E1 activity in a Chinese population
- Trimethadione metabolism by human liver cytochrome P450: evidence for the involvement of CYP2E1
- Influence of genetic admixture on polymorphisms of drug‐metabolizing enzymes: Analyses of mutations on NAT2 and CYP2E1 genes in a mixed Hispanic …
- Role of the proteasome complex in degradation of human CYP2E1 in transfected HepG2 cells
- Association Studies of Polymorphisms of CYP2E1 Gene in Alcoholics with Cirrhosis, Antisocial Personality, and Normal Controls
- Transcriptional and posttranscriptional regulation of CYP2E1, an N-nitrosodimethylamine demethylase.
- Association of CYP2E1, GST and mEH genetic polymorphisms with urinary acrylamide metabolites in workers exposed to acrylamide
- Green tea polyphenol epigallocatechin-3-gallate protects HepG2 cells against CYP2E1-dependent toxicity
- Chronic ethanol feeding potentiates Fas Jo2-induced hepatotoxicity: Role of CYP2E1 and TNF-α and activation of JNK and P38 MAP kinase
- Role of CYP2E1 in deramciclane metabolism
- S-adenosyl methionine protects ob/ob mice from CYP2E1-mediated liver injury
- The influence of genetic polymorphism of CYP2E1 on the development of alcohol liver cirrhosis
- p53 mutation spectrum in relation to GSTM1, CYP1A1 and CYP2E1 in surgically treated patients with non-small cell lung cancer.
- Evidence for a tissue-specific induction of cutaneous CYP2E1 by dexamethasone
- Involvement of CYP2E1 and carboxylesterase enzymes in vinyl carbamate metabolism in human lung microsomes
- Genetic Polymorphisms of CYP2E1 and Risk of Colorectal Adenomas in the Self Defense Forces Health Study
- CYP2E1 Rsa I/Pst I polymorphism and esophageal cancer risk: a meta-analysis based on 1,088 cases and 2,238 controls
- The effect of lycopene on the total cytochrome P450, CYP1A2 and CYP2E1
- Chlorzoxazone metabolism by winter flounder liver microsomes: evidence for existence of a CYP2E1-like isoform in teleosts
- Role of CYP2E1 in the mouse model of MPTP toxicity
- Genetic polymorphism of CYP2E1 and digestive tract alcohol damage among Polish individuals
- CYP2E1 genotyping in renal cell/urothelial cancer patients in comparison with control populations.
- Genetic polymorphisms of CYP2E1, GSTT1, GSTP1, GSTM1, ALDH2, and ODC and the risk of advanced precancerous gastric lesions in a Chinese population
- Transgenic plants of Petunia hybrida harboring the CYP2E1 gene efficiently remove benzene and toluene pollutants and improve resistance to formaldehyde
- Induction of CYP2B and CYP2E1 in precision-cut rat liver slices cultured in defined medium
- Glutathione depletion in CYP2E1-expressing liver cells induces toxicity due to the activation of p38 mitogen-activated protein kinase and reduction of nuclear factor-κB …
- Mammalian cytochrome CYP2E1 triggered differential gene regulation in response to trichloroethylene (TCE) in a transgenic poplar
- CYP2E1 polymorphism, cigarette smoking, p53 expression, and survival in non-small cell lung cancer: a long term follow-up study
- Short-term treatment with alcohols causes hepatic steatosis and enhances acetaminophen hepatotoxicity in CYP2E1 (-/-) mice
- Phosphorylation of cytochrome P4502E1 (CYP2E1) by calmodulin dependent protein kinase protein kinase C and cAMP dependent protein kinase
- PI3K inhibitors reverse the suppressive actions of insulin on CYP2E1 expression by activating stress-response pathways in primary rat hepatocytes
- In vitro metabolism of styrene to styrene oxide in liver and lung of CYP2E1 knockout mice
- Dietary lipids affect human ethanol-inducible CYP2E1 gene expression in vivo in mononuclear cells
- Independent and combined effects of ethanol self-administration and nicotine treatment on hepatic CYP2E1 in African green monkeys
- … of human prenatal biosynthesis of all-trans-retinoic acid by ethanol, ethanol metabolites, and products of lipid peroxidation reactions: a possible role for CYP2E1
- Gene Structure and Multiple Regulations of the Ethanol-Inducible Cytochrome P45O2E1 (CYP2E1) Subfamily
- Role of phospholipase A2 activation and calcium in CYP2E1-dependent toxicity in HepG2 cells
- Panax vietnamensis protects mice against carbon tetrachloride-induced hepatotoxicity without any modification of CYP2E1 gene expression
- Study on the association between genetic polymorphism of CYP2E1, GSTM1 and susceptibility of lung cancer
- A multiplex-PCR/RFLP procedure for simultaneous CYP2E1, mEH and GSTM1 genotyping
- Lycopene attenuates arachidonic acid toxicity in HepG2 cells overexpressing CYP2E1
- APOE and CYP2E1 polymorphisms, alcohol consumption, and Parkinson’s disease in a Japanese population
- Epoxide formation from diallyl sulfone is associated with CYP2E1 inactivation in murine and human lungs
- D2-receptor-linked signaling pathways regulate the expression of hepatic CYP2E1
- Metabolic activation of o-phenylphenol to a major cytotoxic metabolite, phenylhydroquinone: role of human CYP1A2 and rat CYP2C11/CYP2E1
- Expression and activity of CYP2E1 in circulating lymphocytes are not altered in diabetic individuals
- Modification effects of GSTM1, GSTT1 and CYP2E1 polymorphisms on associations between raw salted food and incomplete intestinal metaplasia in a high‐risk …
- Validation of 4-nitrophenol as an in vitro substrate probe for human liver CYP2E1 using cDNA expression and microsomal kinetic techniques
- Depression of glutathione content, elevation of CYP2E1-dependent activation, and the principal determinant of the fasting-mediated enhancement of 1, 3-dichloro-2 …
- Effects of acute renal failure induced by uranyl nitrate on the pharmacokinetics of intravenous theophylline in rats: the role of CYP2E1 induction in 1, 3‐dimethyluric …
- Effects of N-acetyltransferase 2 (NAT2), CYP2E1 and Glutathione-S-transferase (GST) genotypes on the serum concentrations of isoniazid and metabolites in …
- Opposite action of S-adenosyl methionine and its metabolites on CYP2E1-mediated toxicity in pyrazole-induced rat hepatocytes and HepG2 E47 cells
- No significant expression of CYP2E1 in rat liver stellate cells
- CYP2E1 and clinical features in alcoholics
- Comparison of chlorzoxazone one-sample methods to estimate CYP2E1 activity in humans
- Acetaminophen alters microsomal ryanodine Ca2+ channel in HepG2 cells overexpressing CYP2E1
- No Association between Polymorphisms in CYP2E1, GSTM1, NAT1, NAT2 and the Risk of Gastric Adenocarcinoma in the European Prospective Investigation into …
- The effect of isoniazid containing regimen on CYP2E1 during antituberculosis therapy.
- A Haplotype Analysis of CYP2E1 Polymorphisms in Relation to Alcoholic Phenotypes in Mexican Americans
- A reaction network model for CYP2E1-mediated metabolism of toxicant mixtures
- Ca2+-dependent and independent mitochondrial damage in HepG2 cells that overexpress CYP2E1
- Cytochrome b5 reductase and cytochrome b5 support the CYP2E1-mediated activation of nitrosamines in a recombinant Ames test
- Overexpression of CYP2E1 enhances sensitivity of hepG2 cells to fas-mediated cytotoxicity
- INFLUENCE OF GENETIC ADMIXTURE ON POLYMORPHISMS OF ALCOHOL-METABOLIZING ENZYMES: ANALYSES OF MUTATIONS ON THE CYP2E1, ADH2, ADH3 AND …
- Liver nuclear and microsomal CYP2E1-mediated metabolism of xenobiotics in rats chronically drinking an alcohol-containing liquid diet
- Effect of CYP2E1 induction by ethanol on the immunotoxicity and genotoxicity of extended low-level benzene exposure
- Role of nitric oxide and nuclear factor-κB in the CYP2E1 potentiation of tumor necrosis factor α hepatotoxicity in mice
- Identification of sequences responsible for intracellular targeting and membrane binding of rat CYP2E1 in yeast
- Suppression of cytochrome P450 2E1 promoter activity by interferon-γ and loss of response due to the-71G> T nucleotide polymorphism of the CYP2E1* 7B allele
- Identification and functional analysis of a novel human CYP2E1 far upstream enhancer
- Rifampicin suppresses hepatic CYP2E1 expression and minimizes DNA injury caused by carbon tetrachloride in perivenular hepatocytes of mice
- Inhibition of CYP2E1 activity does not abolish pulsatile urine alcohol concentrations during chronic alcohol infusions
- Molecular cloning and sequence analysis of hamster CYP2E1
- Relationship between genetic polymorphism of CYP2E1 and ALDH2, and possible susceptibility to alcoholism
- … mechanism of Wu-Zi-Yan-Zong-Wan, a traditional Chinese herbal formula, against alcohol-induced oxidative damage in CYP2E1 cDNA-transfected HepG2 (E47) …
- … overexpression of catalase in the cytosolic or mitochondrial compartment protects against toxicity caused by glutathione depletion in HepG2 cells expressing CYP2E1
- Effects of steady-state lasofoxifene on CYP2D6-and CYP2E1-mediated metabolism
- [12] Chlorzoxazone: An in vitro and in vivo substrate probe for liver CYP2E1
- CYP2E1-dependent bioactivation of 1, 1-dichloroethylene in murine lung: formation of reactive intermediates and glutathione conjugates
- Modulation of mouse P450 isoforms CYP1A2, CYP2B10, CYP2E1, and CYP3A by the environmental chemicals mirex, 2, 2-bis (p-chlorophenyl)-1, 1-dichloroethylene …
- Lack of cytochrome P450 2E1 (CYP2E1) induction in the rat liver by starvation without coprophagy
- Influence of GSTs, CYP2E1 and mEH polymorphisms on 1, 3-butadiene-induced micronucleus frequency in Chinese workers
- Influence of GSTT1, mEH, CYP2E1 and RAD51 polymorphisms on diepoxybutane-induced SCE frequency in cultured human lymphocytes
- Tightly regulated and inducible expression of rabbit CYP2E1 using a tetracycline-controlled expression system
- Striking LD50 variation associated with fluctuations of CYP2E1-positive cells in hepatic lobule during chronic CCl4 exposure in mice
- Expression of cytochrome P450 enzymes CYP1A1, CYP1B1, CYP2E1 and CYP4B1 in cultured transitional cells from specimens of the human urinary tract and from …
- Isozyme-selective metabolism of ethyl carbamate by cytochrome P450 (CYP2E1) and carboxylesterase (hydrolase A) enzymes in murine liver microsomes
- … of the accumulation of acetaldehyde from ethanol in human prenatal cephalic tissues: evaluation of the relative contributions of CYP2E1, alcohol dehydrogenase, and …
- CYP2E1 and CYP3A1/2 gene expression is not associated with the ursodeoxycholate effect on ethanol-induced lipoperoxidation
- CYP2E1 inhibition enhances mallory body formation
- XRCC1, CYP2E1 and ALDH2 genetic polymorphisms and sister chromatid exchange frequency alterations amongst vinyl chloride monomer-exposed polyvinyl …
- Cytochrome b5 coexpression increases the CYP2E1-dependent mutagenicity of dialkylnitrosamines in methyltransferase-deficient strains of Salmonella typhimurium
- Effect of disulfiram‐mediated CYP2E1 inhibition on the disposition of vesnarinone
- Nitric oxide donors prevent while the nitric oxide synthase inhibitor L-NAME increases arachidonic acid plus CYP2E1-dependent toxicity
- CYP2E1 overexpression inhibits microsomal Ca2+-ATPase activity in HepG2 cells
- Induction of brain CYP2E1 changes the effects of ethanol on dopamine release in nucleus accumbens shell
- The role of phosphatidylinositol 3-kinase, Src kinase, and protein kinase A signaling pathways in insulin and glucagon regulation of CYP2E1 expression
- Voglibose potentiates the hepatotoxicity of carbon tetrachloride and acetaminophen by inducing CYP2E1 in rats
- Administration of the tris salt of α-tocopheryl hemisuccinate inactivates CYP2E1, enhances microsomal α-tocopherol levels and protects against carbon tetrachloride …
- Influence of selected inhibitors on the metabolism of the styrene metabolite 4-vinylphenol in wild-type and CYP2E1 knockout mice
- Lack of common mutation in the alfa-subunit of the mitochondrial trifunctional protein and the polymorphism of CYP2E1 in three Japanese women with acute fatty liver …
- Induction of CYP1A1 and CYP2E1 in rat liver by histamine: binding and kinetic studies
- Cytochrome P4502E1 (CYP2E1) Genetic Polymorphisms in a Lebanese Population: Frequency Distribution and Association with Morbid Diseases
- CYP1A1 and CYP2E1 polymorphism frequencies in a large Brazilian population
- THE EFFECTS OF THE ALDH2*1/2, CYP2E1 C1/C2 AND C/D GENOTYPES ON BLOOD ETHANOL ELIMINATION
- Noninvolvement of CYP2E1 in the (ω-1)-hydroxylation of fatty acids in rat kidney microsomes
- Effect of total alkaloids of Rubus alceaefolius poiron on gene expressions of CYP2E1 and CYP3A1 in rats with acute liver injury
- Watercress has no importance for the elimination of ethanol by CYP2E1 inhibition
- Inhibition of rat hepatic CYP2E1 by quinacrine: molecular modeling investigation and effects on 4-(methyl nitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced …
- Undernutrition during hyperoxic exposure induces CYP2E1 in rat liver
- Transcriptional activity of the tandem repeat polymorphism in the 5′‐flanking region of the human CYP2E1 gene
- Trifluoroacetylated adducts in spermatozoa, testes, liver and plasma and CYP2E1 induction in rats after subchronic inhalatory exposure to halothane
- A polymorphism in the 5′-flanking region of the CYP2E1 gene and elevated lung adenocarcinoma risk in a Japanese population
- Polymorphisms of the CYP1A1, CYP2E1 and XRCC1 genes and cancer risk in a Southern Italian population: a case–control study
- CYP2E1 level in rat liver injured by the interaction between carbon tetrachloride and chloroform
- Serum autoantibodies against cytochrome P450 2E1 (CYP2E1) predict severity of necroinflammation of recurrent hepatitis C
- Association of CYP2E1 of PON2311 polymorphisms in neonates with preterm
- Role of CYP2E1 in ketone-stimulated insulin release in pancreatic B-cells
- Relative roles of CYP2E1 and CYP1A2 in mouse uroporphyria caused by acetone
- Extrahepatic metabolism by CYP2E1 in PBPK modeling of lipophilic volatile organic chemicals: impacts on metabolic parameter estimation and prediction of dose …
- Use of Duplex PCR-CTPP Methods for CYP2E1 RsaI/IL-2 T-330G and IL-1B C-31T/TNF-A T-1031C Polymorphisms
- Examination of a CYP2E1 repeat polymorphism in a monkey model of alcohol abuse
- CYP2E1 overexpression up-regulates both non-specific δ-aminolevulinate synthase and heme oxygenase-1 in the human hepatoma cell line HLE/2E1
- Metabolism and toxicity of the styrene metabolite 4-vinylphenol in CYP2E1 knockout mice
- Protein kinase C signaling as a survival pathway against CYP2E1-derived oxidative stress and toxicity in HepG2 cells
- Urinary excretion of 6‐hydroxychlorzoxazone as an index of CYP2E1 activity
- Cloning and expression of rat CYP2E1 in Saccharomyces cerevisiae: Detection of genotoxicity of N‐alkylformamides
- Role of the Genetic Polymorphisms in the 5′‐Flanking Region for Transcriptional Regulation of the Human CYP2E1 Gene
- Role of polymorphic variants of cytochrome P450 genes (CYP1A1, CYP2E1) and microsomal epoxide hydrolase (mEPHX) in pathogenesis of cystic fibrosis and …
- Conformational anti‐cytochrome P4502E1 (CYP2E1) auto‐antibodies contribute to necro‐inflammatory injury in chronic hepatitis C
- Relation of GSTP1 and CYP2E1 polymorphisms with susceptibility to acute leukemia
- Decreased CYP2E1 mRNA expression in human leucocytes in patients with fibrotic and inflammatory lung diseases
- ALDH2 and CYP2E1 genotypes, urinary acetaldehyde excretion and the health consequences in moderate alcohol consumers
- The NH2-terminal region of rabbit CYP2E1 is not essential for interaction with NADPH-cytochrome P450 reductase
- Effect of high‐dose aspirin on CYP2E1 activity in healthy subjects measured using chlorzoxazone as a probe
- Genetic variation in the temperature dependence of liver microsomal CYP2E1 activity, within and between species of the viviparous fish Poeciliopsis
- Insertional polymorphism of the CYP2E1 gene in infiltrative pulmonary tuberculosis in populations of Bashkortostan Republic
- Cryopreserved porcine hepatocytes: expression and induction of cytochrome P450, isoform CYP2E1
- Comparison of levels of cytochromes P‐450, CYP1A2, CYP2E1, and their related monooxygenase activities in human surgical liver samples
- Modulation of ethanol-mediated CYP2E1 induction by clofibrate and L-carnitine in rat liver
- The effect of endotoxin on hepatocyte nuclear factor 1 nuclear protein binding: potential implications on CYP2E1 expression in the rat
- Effect of CYP2E1 polymorphism on DNA stability and lung cancer susceptibility
- Area Under the Plasma Concentration–Time Curve of Inorganic Fluoride Following Sevoflurane Anesthesia Correlates with CYP2E1 mRNA Level in Mononuclear …
- Identification of a 16-nucleotide sequence that mediates post-transcriptional regulation of rat CYP2E1 by insulin
- Fetal and maternal CYP2E1 genotypes and the risk of nonsyndromic oral clefts
- Bioactivation of 1, 1-dichloroethylene to its epoxide by CYP2E1 and CYP2F enzymes
- Exacerbation of benzene pneumotoxicity in connexin 32 knockout mice: enhanced proliferation of CYP2E1-immunoreactive alveolar epithelial cells
- Comparison of cytochrome P4502E1 (CYP2E1) activity and hepatic and lymphocyte mRNA expression in patients with chronic hepatitis C
- IL-4-mediated transcriptional regulation of human CYP2E1 by two independent signaling pathways
- Phorbol ester induces CYP2E1 in astrocytes, through a protein kinase C‐and tyrosine kinase‐dependent mechanism
- Role of phosphatidylinositol 3-kinase/AKT as a survival pathway against CYP2E1-dependent toxicity
- Polymorphism of the 5′‐Flanking Region of the CYP2E1 Gene: An Association Study With Alcoholism
- Activity of immobilised rat hepatic microsomal CYP2E1 using alumina membrane as a support
- Increased toxicity by transforming growth factor-beta 1 in liver cells overexpressing CYP2E1
- Isolation of the mouse cytochrome P450J (CYP2E1) cDNA and its reciprocal testosterone regulation in kidney and liver
- Hepatotoxicity Mediated by Pyrazole (CYP2E1) Plus TNF-α Treatment Occurs in jnk2−/− but not in jnk1−/− Mice
- A comparison of the inhibitory effects of four volatile anaesthetics on the metabolism of chlorzoxazone, a substrate for CYP2E1, in rabbits
- Contribution of the ALDH2 and CYP2E1 genes to flushing response and drinking patterns in Japanese healthy volunteers
- Assessment of frequencies of lifestyle factors and polymorphisms of drug-metabolizing enzymes (NAT2, CYP2E1) in human hepatocellular carcinoma (HCC) patients …
- Upregulation of CYP2E1 and cyp3a activities in histamine-deficient histidine decarboxylase gene targeted mice
- Low-dose diethyldithiocarbamate attenuates the hepatotoxicity of 1, 3-dichloro-2-propanol and selectively inhibits CYP2E1 activity in the rat
- Comparison of the polymorphic regions of the cytochrome P450 CYP2E1 gene of humans and patas and cynomolgus monkeys
- Cytochrome p-450-mediated differential oxidative modification of proteins: albumin, apolipoprotein E, and CYP2E1 as targets
- Activation of alkylhydrazines to free radical intermediates by ethanol-inducible cytochrome P-4502E1 (CYP2E1)
- Insertion Polymorphism of the CYP2E1 gene in patients with infiltrative pulmonary tuberculosis from Bashkortostan
- Dichloroacetic acid treatment increases hepatic CYP2E1 in male and female rats
- Altered ethylbenzene-mediated hepatic CYP2E1 expression in growth hormone-deficient dwarf rats
- Polymorphisms of the cytochrome P450 (CYP1A1, CYP2E1) and microsomal epoxide hydrolase (mEPHX) genes in cystic fibrosis and chronic respiratory disease
- … , Scrophularia ningpoensis, Asparagus cochinchinensis and Ophiopogon japonicas on contents of CYP450 and activities of CYP3A, CYP2E1 and CYP1A2 in rat
- Genetic regulation of liver microsomal CYP2E1 activity among strains of the viviparous fishes Poeciliopsis occidentalis and Poeciliopsis lucida
- Diminished CYP2E1 expression and formation of 2-S-glutathionyl acetate, a glutathione conjugate derived from 1, 1-dichloroethylene epoxide, in murine lung tumors
- Effect of 1-aminobenzotriazole on the in vitro metabolism and single-dose pharmacokinetics of chlorzoxazone, a selective CYP2E1 substrate in Wistar rats
- The genetic regulation of liver microsomal CYP2E1 activity among strains of the viviparous fish Poeciliopsis
- Bioactivation of 1, 1-dichloroethylene by CYP2E1 and CYP2F2 in murine lung
- Effects of chlorinated aliphatic hydrocarbons on the fidelity of cell division in human CYP2E1 expressing cells
- Abnormal liver function associated with polymorphism of GSTT1, GSTM1 and CYP2E1 in workers exposed to N, N-dimethylformamide
- CYP2E1–Biochemical and Toxicological Aspects and Role in Alcohol-Induced Liver Injury
- Case-control study of the polymorphisms of CYP2E1-RsaⅠ and STT1 genes and susceptibility to pancreatic cancer
- Genetic polymorphisms of alcohol inducible CYP2E1 in Turkish population
- Expression of human CYP2E1 in insect cells using bac-to-bac expression system
- A Case-control study on effects of genetic polymorphisms of GSTM1, GSTT1, CYP1A1 and CYP2E1 on risk of lung cancer
- Glucose inhibition of the induction of CYP2E1 mRNA expression by ethanol in FGC-4 cells
- Effect of methacrylonitrile on cytochrome P-450 2E1 (CYP2E1) expression in male F344 rats
- … of liver microsomal 7-ethoxycoumarin O-deethylation and chlorzoxazone 6-hydroxylation activities in Japanese and Caucasian subjects genotyped for CYP2E1 gene
- No linkage of the cytochrome P-450IIE1 (CYP2E1) C1/C2 polymorphism to schizophrenia
- Antibodies against CYP2E1 after exposure to 1, 1, 1-trifluoroethane and 1, 1, 1, 2-tetrafluoroethane
- Overexpression of CYP2E1 induces HepG2 cells death by the AMP kinase activator 5′-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICAR)
- Immunohistochemical Detection of CYP2E1 and 2-S-Glutathionyl Acetate in Murine Lung Tumors: Diminished Formation of Reactive Intermediates of 1,1 …
- CYP2E1 genotypes and serum LAP in Japanese alcoholics
- Genetic polymorphisms of CYP2E1
- Non-positive autoimmune responses against CYP2E1 in refrigeration mechanics exposed to halogenated hydrocarbons
- Development of a non-high pressure liquid chromatography assay to determine [14C] chlorzoxazone 6-hydroxylase (CYP2E1) activity in human liver microsomes
- The colorectal cancer risk of meat intake, smoking, and CYP2E1 polymorphisms: the comparison of colorectal cancer patients with controls
- Genetic Polymorphism of Alcohol Metabolizing Enzymes, CYP2E1
- Relationship between CYP2E1 polymorphism and increase of ALT activity during therapy of patients with pulmonary tuberculosis
- Halothane inhalation inhibits the metabolism of chlorzoxazone, a substrate for CYP2E1, in rabbits
- Analysis of CYP2E1 and GSTM1 polymorphisms for the determination of genetic susceptibility to Korean patients with colon cancer
- Inactivation of cytochrome P-450 (CYP2E1) and carboxylesterase (hydrolase A) enzymes by vinyl carbamate in murine pulmonary microsomes
- Antibiotic furazolidone induces CYP1A but not CYP2E1 subfamily in rat liver
- Effect of starvation and acetone on the enzyme systems of biotransformation and toxicity of xenobiotics–CYP2E1 substrates in rats
- Comparative analysis of binding affinities between styrene and mammalian CYP2E1 by bioinformatics approaches
- Study of the fragmentation mechanism of protonated 6-hydroxychlorzoxazone: application in simultaneous analysis of CYP2E1 activity with major human cytochrome …
- Gene CYP2E1 expression in mouse liver cells exposed to low-dose radiation
- Interaction of polymorphisms of CYP2E1 and environmental risk factors in gastric cancer
- Effect of Genetic Polymorphisms of CYP2E1 and ALDH2 on the Relationship between the Levels of Urinary 8-Hydroxydeoxyguanosine and t, t-Muconic Acid
- Trimethadione N-demethylation by rat liver CYP2E1 in vitro.
- Correlation analyses of ALDH2 and CYP2E1 genetic polymorphism with personality
- Variations in expression of CYP2E1 and COUP-TF1 proteins between Large White and Duroc cross-breeds
- GYKI-47261, a new AMPA [2-amino-3-(3-hydroxymethylisoxazole-4-yl) propionic acid] antagonist, is a CYP2E1 inducer
- Research on the relationship between ALDH2 and CYP2E1 gene polymorphism and alcoholic liver disease in Han people
- Differential expression of cytochrome P4502E1 (CYP2E1) in Morris hepatomas and livers of tumor bearing rats.
- A novel lipopolysaccharide‐modulated Jun binding repressor in intron 2 of CYP2E1
- Association analysis of alcohol metabolizing enzymes ADH1B, ADH7, CYP2E1 gene polymorphism with risk for coronary atherosclerosis
- Identification of polymorphisms in CYP2E1 gene and association analysis among chronic HBV patients
- Increase expression of CYP2E1 mRNA after methamphetamine administration in rats
- The role of CYP2E1 in the protection of garlic oil’s from n-hexane-induced neurotoxicity
- Pulmonary bioactivation of 1, 1-dichloroethylene is associated with CYP2E1 levels in A/J, CD-1, and C57BL/6 mice
- Ethanol-induction of cytochrome P450 2A5: permissive role for CYP2E1
- Characterization of a dietary ethanol protocol for CYP2E1 induction in the CD-1 mouse without evident hepatic toxicity or genotoxicity
- A decrease in S-adenosyl-L-methionine potentiates arachidonic acid cytotoxicity in primary rat hepatocytes enriched in CYP2E1
- Cytochemical Localization of the Acetone-lnducible Cytochrome P-450 Isoform, CYP2E1 in Murine Colonic Epithelium
- A study for regulation of ethanol-inducible P450 (CYP2E1) on CCl4-induced hepatic damage
- Associations of Rsa I polymorphism at the 5’flanking region of CYP2E1 and PON2 148 polymorphism in neonates with preterm delivery
- Effect of sulfur dioxide inhalation on CYP2B1/2 and CYP2E1 in rat liver and lung
- Genetic polymorphism of human CYP2E1: new allels detected in exons and exon-intron junctions
- Relationship between alcoholism and CYP2E1 genotypes
- A case control study on the impact of CYP2E1 and GST-M1 polymorphisms on the risk of lung cancer
- Preliminary effects of alcohol and Curcuma longa upon CYP2E1 and hematotoxicity in benzene-induced mice
- Association of genetic polymorphisms of aldehyde dehydrogenase II and CYP2E1 and clinical characteristics of patients with alcohol dependence
- Downregulation of the CYP2E1 ameliorates oxidative stress and apoptosis
- Interaction between genetic polymorphisms of CYP2E1 & NAT1 and smoking in lung cancer development (Preliminary report)
- Human CYP2E1 developmental expression: a role in fetal and pediatric susceptibility to toxicants?
- Effects of environmental carcinogens and genetic polymorphisms of CYP2E1 and NAT2 on gastric carcinogenesis
- Effects of Purified Glycerol from Biodiesel on Cyp1a1 and CYP2E1 Expressions in CBA/CA Mice
- Fast CYP2E1 genotyping using automated fluorescent detection.
- Association of CYP2E1, NQO1 and GST genetic polymorphisms with risk of acute lymphoblastic leukemia in turkish children
- Ruthenium red protects HepG2 cells overexpressing CYP2E1 against acetaminophen cytotoxicity
- CYP2E1 competes with CYP2B4 for limited NADPH‐Cytochrome P450 Reductase
- Expression and regulation of cytochrome P450 CYP2E1 in the minipig
- Effect of TFHL on expression of CYP2E1 in liver tissue of rats with NASH.
- Effects of ginsenoside Rd and Panax ginseng extract on Cyp1a, Cyp2b, Cyp2c, CYP2E1, and Cyp3a activities in C57BL/6JNarl mice
- The research on the relationship between CD44, CYP2E1 genetic polymorphisms and esophageal cancer
- Action-mechanisms of Genetic Polymorphism in the CYP2E1 on Susceptibility to Polycyclic Aromatic Hydrocarbons
- CYP1A1, CYP2E1 and gastric cancer risk in a high-incidence Colombian population
- Ontogeny of Rat CYP2E1 and CYP1A2: A Characterization and
- Effects of mitomycin (MMC) and {gamma}-ray irradiation on cytochrome p450 content and activities of CYP2B1 and CYP2E1 in rats
- The modeling of interactions of the CYP2E1 isoform of human cytochrome P450 with substrates
- Identification of CYP2E1-dependent genes involved in carbon tetrachloride-induced hepatotoxicity
- Evidence for the Existence of Two Human CYP2E1 cDNAs Using Different Polyadenylation Signals
- Functional polymorphism of CYP2E1 gene and alcohol use disorders in a Tibetan population.
- The ethanol elimination pharmacokinetics–the effects of genotypes of ALDH2 and CYP2E1 on the ethanol metabolism
- Differential expression profile of cytochrome p450 2E1 (CYP2E1) related genes associated with carbon tetrachloride-induced hepatotoxicity
- Effect of total saikosaponins on the intestinal first-pass effect and liver Cyp3a, CYP2E1
- Relationship between gene polymorphism of CYP2E1, CYP1A1, IL-4 and medicamentosa-like dermatitis induced by trichloroethylene
- High dose lycopene supplementation increases hepatic CYP2E1 protein and TNF‐α expression in alcohol fed rats
- The ethanol elimination pharmacokinetics–the effects of genotypes of ALDH2 and CYP2E1 on the ethanol metabolism
- Silibinin inhibits CYP2E1‐dependent ethanol metabolism, oxidative stress and cell proliferation in a rat model of hepatocellular carcinoma (HCC)
- Opposite effects of isoniazid and fasting on the expression of CYP2E1 protein and mRNA in house musk shrew (Suncus murinus)
- Computational docking studies of nitroanisoles and nitrophenols with CYP2E1
- ALDH and CYP2E1 Single Nucleotide Polymorphism Distribution in Korean
- Role of CYP2E1 in Hepatocarcinogenesis and Hepatotoxicity
- An investigation of CYP2E1 phenotype determination utilizing modeling and simulation studies
- Formation of Multiple CYP2E1 Complexes Affects Activity
- Regulation of CYP2E1 and Tissue Protection Effect of CYP2E1 Inhibitor
- Mapping of pig CYP2E1 to SSC14
- ALDH and CYP2E1 Single Nucleotide Polymorphism Distribution in Korean
- CYP2E1 mutation associated with increased chlorzoxazone (CZ) metabolic ability
- Alcohol, Nicotine and Genetic Variation Influence CYP2E1
- Different CYP2E1 genotypes and alcoholic liver disease.
- Establishment and toxicological application of a cell line expressing human CYP2E1
- The Toxicological Mechanism Of Styrene In CYP2E1 Transgenic Cells
- Effect of CYP2E1 Ras I genotypes on CYP2E1 enzyme activity and DNA damage induced by phenol in immortalized human lymphocytes
- Effects of environmental factors on extrahepatic CYP2E1 gene expression in mice
- Molecular Evidence for the Presence of CYP2E1 Retropseudogene in Human Genome
- Role Of Mouse CYP2E1 In The O-Hydroxylation Of P-Nitrophenol: Comparison Of Activities In CYP2E1 (-/-) And Wildtype Mice
- Structure-functional characterization of cytochrome P4502E1 (CYP2E1)
- Establishment of model with exogenous human CYP2E1 expression and inducement of substrates
- Chlorzoxazone as a Single Sample Probe of Hepatic CYP2E1 Activity
- A relationship between genetic polymorphisms of CYP2E1 and susceptibility of acute leukemia in Gansu population
- Application of a map Bayesian method for CYP2E1 phenotyping
- Role of CYP2E1 Immunoglobulin G4
- Individual variability of CYP2E1 xenobiotic oxidation in human liver
- The genotype of CYP2E1 and liver-derived serum enzymes
- A-71G> T Nucleotide Substitution uncouples IFN-[gamma]-dependent Suppression of CYP2E1 mRNA
- Pathogenesis of nonalcoholic steatohohepatitis [sic]: the role of CYP2E1
- Hormonal regulation of CYP2E1 and CYP2C11 in rat liver and kidney
- Inhibition of Ethanol-induced CYP2E1 by Curcuma longa L. Extract
- Immunological detection of CYP2E1 in the fresh lymphocytes
- THE EFFECT OF COPROPHAGY ON THE EXPRESSION OF HEPATIC CYP2E1 DURING STARVATION
- Effects of Danshen and Its Active Components on Rat CYP2E1 Expression and Metabolism of Model CYP2E1 Probe Substrate
- Construction of CYP2E1 recombinant adenovirus vector and its anti-tumor effects
- CYP2E1-DEPENDENT BIOACTIVATION OF 191
- Role Of Cytochrome P450 2E1 (CYP2E1) In Trichloroethylene (TCE) Metabolism And Disposition: Comparative Studies Using CYP2E1-/-And Wild-Type Mice
- The role of CYP2E1 and CYP4A in the development of non-alcoholic steatohepatitis
- CYP2E1 VNTR polymorphisms and hepatocarcinoma: a gender-specific correlation
- Substrate inhibition of CYP2E1 activity is primarily determined by lipophilicity
- Expression of CYP2E1 gene in liver tissue in patients with hepatic cirrhosis and obstuctive jaundice
- Study on the association between CYP2E1 enzymes and susceptibility of alcoholic liver disease
- An investigation of the induction of hepatic CYP2E1 by low doses of nicotine in the rat.
- The Effects of CYP2E1 and CYP2C19 Polymorphisms on the Susceptibility for Gastric Cancer
- Time-coursed Changes of CYP2E1 Protein in Acute Liver Injury by a Single CCI₄ Administration in SD Rats
- Search for possible changes in murine gene CYP2E1 structural region under exposure to ionizing radiation
- MAPPING CONFORMATIONAL CYP2E1 EPITOPES RECOGNISED BY AUTO-ANTIBODIES IN HALOTHANE HEPATITIS AND ALCOHOLIC LIVER DISEASE
- The Genetic Polymorphism of CYP2E1 in a Korean Healthy Subjects and Hepatocellular Carcinoma Patients
- Associations between CYP2E1 promoter polymorphisms and plasma 1, 3-dimethyluric acid/theophylline ratio
- CYP2E1 Genetic Polymorphism relating to Styrene Metabolism of Korean Workers
- Pharmacokinetics of drug interactions due to ligand stabilization of CYP2E1
- Determination of the activity of human hepatic cytochromes P450 CYP2C8/9, CYP2E1
- ALLELIC VARIANTS OF CYP2E1 GENE IN HEPATOCARCINOMA PATIENTS AND IN HEPATIC TUMOR CELL LINES
- e0048 CYP2E1 increases oxidative stress and induces apoptosis of cardio myocytes in transgenic mice
- Catalytic activity and quantitation of CYP2E1 in human embryonic and fetal brain tissues
- Various Fatty Acids Induce Cell Damages Differently in CYP2E1-transduced HepG2 Cells, E47 Cells, Compared to C34 Cells
- Polymorphisms of ADH2, ALDH2 and CYP2E1 in huichol and Mestizo subjects from western México in comparison with other populations of the world
- Cloning and sequence analysis of human embryonic nasopharyngeal epithelial CYP2E1 cDNA
- The influence of Jiuganning decoction on the content of CYP2E1 and cytokine IL-6, TNF in rats models of alcoholic hepatic injury
- Identification of a critical CYP2E1 epitope in patients with drug-induced liver injury from anesthetics (93.16)
- Experimental study on effect of Erchen decoction and Taohongsiwu decoction on CYP2E1 activities in non-alcoholic fatty liver rats
- Use of Cytochrome P450 2E1 (CYP2E1) Knockout Transgenic Mouse Model to Study the Role of CYP2E1 in Carbon Tetrachloride-and Alcohol-mediated …
- The role of CYP2A6 and CYP2E1 in the metabolism of 3-methylindole in porcine hepatocytes.
- Role of CYP2E1 in Impaired Nitric Oxide Synthase (NOS)‐Dependent Cerebral Vasodilation During Chronic Alcohol Consumption
- Increased citrate levels in non-alcoholic steatohepatitis: effect on CYP2E1
- The Role of CYP2E1 IgG4 Subclass Autoantibodies in the Development of Anesthetic Sensitization
- Cutaneous CYP2E1 induction after topical treatment by dexamethasone, ethanol and salicylic acid in mouse.
- Meta-analysis on relationship between polymorphisms of CYP2E1 gene and susceptibility to antituberculosis drug-induced liver injury
- Modulation of Murine CYP2E1 Activity by Disulfiram on Trichloroethylene-Induced Neurotoxicity A Pilot Study
- Chlormethiazole, an inhibitor of CYP2E1, prevented chemical carcinogen-initiated and alcohol-promoted hepatic carcinongenesis in rats.
- Single Nucleotide Polymorphisms in the Non-coding region of CYP2E1 among Koreans
- The Effects of Poly IC and Human Interferon ɑ on Rat Hepatic Cyp4a1 and CYP2E1
- Inhibition of Urethane-Induced Carcinogenicity in CYP2E1-/-Vs. CYP2E1+/+ Mice
- Polymorphism of CYP2E1 gene and the risk of lung cancer among African-Americans and Caucasians in Los Angeles County (California).
- Association of the blood biochemical index with CYP2E1 5’flanking region Rsa I/Pst I gene polymorphism and alcohol consumption habit in Southern Taiwan …
- The Effects of Chungganhaeju-tang(Qingganjiejiu-tang) on Alcohol induced Cytotoxicity in CYP2E1-transfected HepG2 cells.
- Investigation of indazole unbinding pathways in CYP2E1 by molecular dynamics simulations
- CYP2E1: Mechanism of induction by isoniazid and role in acetaminophen oxidation
- The relationship between the GST T1, GST M1, CYP2E1 genotype and abnormal liver function in PVC workers
- Analyses of Mutation Frequency on the CYP2E1, ADH2, and ALDH2 Genes among Five Ethnic Groups
- Molecular Regulation of Ethanol-inducible P450 (CYP2E1) in Acute CCI₄Treatment
- CYP2E1-dependent bioactivation of 1, 1-dichloroethylene to reactive intermediates in murine and human lung and liver microsomes.
- CYP2E1 Mediates Ethanol-Induced DNA Damage And TNF Release In Bronchial Epithelial Cells
- Oral clefts, maternal exposure to solvents and CYP2E1 polymorphism
- Effect of γ-irradiation and mitomycin C (MMC) on CYP2B1 and CYP2E1 activities in rat hepatic microsomes in vitro
- The Effects of CYP2E1 on Hepatic Gene Expression in 129/Sv-CYP2E1^ tm1Gonz/J and 129S1/SvImJ Mice Exposed to Hydrazine
- Variable Number of Tandem Repeats (VNTR) gene polymorphism of CYP2E1 in patients with pancreatic adenocarcinoma
- THE EFFECT OF ETHANOL ON COUMARIN METABOLISM AND CYTOTOXICITY IN TRANSFECTED CULTURES OF HEPG2 CELLS WITH CYP2E1 EXPRESSION.
