GENOMIC INSTABILITY
December 8, 2023(NRF2) (ACTIVATOR | ACTIVATORS | ACTIVATION)
December 8, 2023- Nasal Colivelin treatment ameliorates memory impairment related to Alzheimer’s disease
- Arctigenin effectively ameliorates memory impairment in Alzheimer’s disease model mice targeting both β-amyloid production and clearance
- Lactobacillus pentosus var. plantarum C29 ameliorates memory impairment and inflammaging in a D-galactose-induced accelerated aging mouse model
- Tanshinone I enhances learning and memory, and ameliorates memory impairment in mice via the extracellular signal‐regulated kinase signalling pathway
- Gami-Chunghyuldan ameliorates memory impairment and neurodegeneration induced by intrahippocampal Aβ1–42 oligomer injection
- Angelica polysaccharide ameliorates memory impairment in Alzheimer’s disease rat through activating BDNF/TrkB/CREB pathway
- Dihydromyricetin ameliorates memory impairment induced by acute sleep deprivation
- Ferulic acid ameliorates memory impairment in d-galactose-induced aging mouse model
- Chronic ghrelin administration restores hippocampal long‐term potentiation and ameliorates memory impairment in rat model of Alzheimer’s disease
- Dexmedetomidine ameliorates memory impairment in sleep-deprived mice
- Guarana (Paullinia cupana) ameliorates memory impairment and modulates acetylcholinesterase activity in Poloxamer-407-induced hyperlipidemia in rat …
- Berberine exerts an anticonvulsant effect and ameliorates memory impairment and oxidative stress in a pilocarpine-induced epilepsy model in the rat
- Treadmill exercise ameliorates memory impairment through ERK-Akt-CREB-BDNF signaling pathway in cerebral ischemia gerbils
- Simvastatin ameliorates memory impairment and neurotoxicity in streptozotocin-induced diabetic mice
- Anticonvulsant effect of piperine ameliorates memory impairment, inflammation and oxidative stress in a rat model of pilocarpine-induced epilepsy
- Xanthohumol ameliorates memory impairment and reduces the deposition of β-amyloid in APP/PS1 mice via regulating the mTOR/LC3II and Bax/Bcl-2 signalling …
- Qingxin kaiqiao fang ameliorates memory impairment and inhibits apoptosis in APP/PS1 double transgenic mice through the MAPK pathway
- (−)-Epigallocatechin-3-gallate ameliorates memory impairment and rescues the abnormal synaptic protein levels in the frontal cortex and hippocampus in a mouse …
- GJ-4 ameliorates memory impairment in focal cerebral ischemia/reperfusion of rats via inhibiting JAK2/STAT1-mediated neuroinflammation
- Deferiprone ameliorates memory impairment in Scopolamine-treated rats: The impact of its iron-chelating effect on β-amyloid disposition
- The phosphodiesterase type-5 inhibitor, tadalafil, improves depressive symptoms, ameliorates memory impairment, as well as suppresses apoptosis and enhances …
- 2,2′,4′‐Trihydroxychalcone from Glycyrrhiza glabra as a new specific BACE1 inhibitor efficiently ameliorates memory impairment in mice
- Phytoestrogen α-zearalanol ameliorates memory impairment and neuronal DNA oxidation in ovariectomized mice
- Oxymatrine ameliorates memory impairment in diabetic rats by regulating oxidative stress and apoptosis: involvement of NOX2/NOX4
- 2-Pentadecyl-2-oxazoline ameliorates memory impairment and depression-like behaviour in neuropathic mice: possible role of adrenergic alpha2-and H3 …
- Danggui-Jakyak-San ameliorates memory impairment and increase neurogenesis induced by transient forebrain ischemia in mice
- 17-AAG post-treatment ameliorates memory impairment and hippocampal CA1 neuronal autophagic death induced by transient global cerebral ischemia
- Cotinine ameliorates memory and learning impairment in senescent mice
- The novel nootropic compound DM232 (UNIFIRAM) ameliorates memory impairment in mice and rats
- Kisspeptin-13 ameliorates memory impairment induced by streptozotocin in male rats via cholinergic system
- Sodium valproate ameliorates memory impairment and reduces the elevated levels of apoptotic caspases in the hippocampus of diabetic mice
- Preischemic treadmill exercise ameliorates memory impairment and microvasculature damage in rat model of chronic cerebral hypoperfusion
- A humanin derivative reduces amyloid beta accumulation and ameliorates memory deficit in triple transgenic mice
- Combination of proanthocyanidins extracted from lotus seedpod and l-cysteine ameliorates memory impairment induced by alcohol and scopolamine in mice
- Dangguijakyak-san ameliorates memory deficits in ovariectomized mice by upregulating hippocampal estrogen synthesis
- DMTHB ameliorates memory impairment in Alzheimer’s disease mice through inhibition of IL-16 signaling
- 7-Deoxy-trans-dihydronarciclasine Reduces β-Amyloid and Ameliorates Memory Impairment in a Transgenic Model of Alzheimer’s Disease
- Physical exercise ameliorates memory impairment in rat pups with maternal lipopolysaccharide-induced cerebral palsy
- Biflorin ameliorates memory impairments induced by cholinergic blockade in mice
- Fructus corni officinalis water extract ameliorates memory impairment and beta amyloid (Aβ) clearance by LRP-1 expression in the hippocampus of a rat model of …
- Correction to: 2-Pentadecyl-2-oxazoline ameliorates memory impairment and depression-like behaviour in neuropathic mice: possible role of adrenergic …
- Intravenous adipose-derived stem cells transplantation ameliorates memory impairment in moderate traumatic brain injury rats via the phosphorylation of …
- A novel heptapeptide, GPPGPAG transfers to the brain, and ameliorates memory dysfunction and dendritic atrophy in Alzheimer’s disease model mice
- Human placenta extract ameliorates memory dysfunction and dendritic atrophy in a 5XFAD mouse model of A lzheimer’s disease
- AMPK ameliorates tau acetylation and memory impairment through Sirt1
- Secreted calmodulin-like skin protein ameliorates scopolamine-induced memory impairment
- Inhibition of central angiotensin converting enzyme ameliorates scopolamine induced memory impairment in mice: role of cholinergic neurotransmission, cerebral …
- Lactobacillus pentosus var. plantarum C29 ameliorates age‐dependent memory impairment in Fischer 344 rats
- The AMPA receptor allosteric potentiator PEPA ameliorates post-ischemic memory impairment
- Antioxidative activity and ameliorative effects of memory impairment of sulfur‐containing compounds in Allium species
- A multifunctional compound ebselen reverses memory impairment, apoptosis and oxidative stress in a mouse model of sporadic Alzheimer’s disease
- Effects of idebenone on memory impairment induced in ischemic and embolization models of cerebrovascular disturbance in rats
- Chronic inhibition of central Angiotensin-converting enzyme ameliorates colchicine-induced memory impairment in mice
- Catalog Number: T0229 CAS Number: 123441-03-2 Molecular Formula: C14H22N2O2 Molecular Weight: 250.34 Appearance: Solid
- Rehmannia glutinosa ameliorates scopolamine-induced learning and memory impairment in rats
- A mini-review of the mechanisms of glucose memory enhancement
- Activation of ERα and/or ERβ ameliorates cognitive impairment and apoptosis in streptozotocin-induced diabetic mice
- Baicalein ameliorates aβ-induced memory deficits and neuronal atrophy via inhibition of PDE2 and PDE4
- Juglanin ameliorates LPS-induced neuroinflammation in animal models of Parkinson’s disease and cell culture via inactivating TLR4/NF-κB pathway
- Adenosine A2A receptor agonist polydeoxyribonucleotide ameliorates short-term memory impairment by suppressing cerebral ischemia-induced …
- Effects of osthole microemulsion by nasal administration on the cholinergic pathway in mice treated with scopolamine
- Taking advantage of the selectivity of histone deacetylases and phosphodiesterase inhibitors to design better therapeutic strategies to treat Alzheimer’s …
- PMC-12, a traditional herbal medicine, enhances learning memory and hippocampal neurogenesis in mice
- Pharmacological studies of a novel prolyl endopeptidase inhibitor, JTP-4819, in rats with middle cerebral artery occlusion
- ERα and/or ERβ activation ameliorates cognitive impairment, neurogenesis and apoptosis in type 2 diabetes mellitus mice
- Mangiferin ameliorates scopolamine-induced learning deficits in mice
- Treadmill exercise ameliorates impairment of spatial learning memory in pups born to old and obese mother rats
- Treadmill exercise ameliorates short-term memory impairment by suppressing hippocampal neuroinflammation in poloxamer-407-induced hyperlipidemia rats
- Berberine chloride improved synaptic plasticity in STZ induced diabetic rats
- Memantine improves memory for taste-avoidance learning in day-old chicks exposed to isolation stress
- Cognitive Ameliorating Effect of Acanthopanax koreanum Against Scopolamine‐Induced Memory Impairment in Mice
- Montelukast ameliorates streptozotocin-induced cognitive impairment and neurotoxicity in mice
- Annona atemoya leaf extract ameliorates cognitive impairment in amyloid-β injected Alzheimer’s disease-like mouse model
- Centella asiatica Prevents Increase of Hippocampal Tumor Necrosis Factor- Independently of Its Effect on Brain-Derived Neurotrophic Factor in Rat Model of …
- Reducing HDAC6 ameliorates cognitive deficits in a mouse model for Alzheimer’s disease
- Protective effects of Colivelin against Alzheimer’s disease in a PDAPP mouse model
- Paroxetine ameliorates prodromal emotional dysfunction and late-onset memory deficit in Alzheimer’s disease mice
- Hilar interneuron vulnerability distinguishes aged rats with memory impairment
- Ethanolic extract of the seed of zizyphus jujuba var. spinosa ameliorates cognitive impairment induced by cholinergic blockade in mice
- Geniposide ameliorates cognitive deficits by attenuating the cholinergic defect and amyloidosis in middle-aged Alzheimer model mice
- DL-3-n-butylphthalide (NBP) ameliorates cognitive deficits and CaMKII-mediated long-term potentiation impairment in the hippocampus of diabetic db/db mice
- Arctigenin ameliorates renal impairment and inhibits endoplasmic reticulum stress in diabetic db/db mice
- Silymarin sex-dependently improves cognitive functions and alters TNF-α, BDNF, and glutamate in the hippocampus of mice with mild traumatic brain injury
- The role of PI3K/AKT/mTOR pathway in the modulation of autophagy and the clearance of protein aggregates in neurodegeneration
- Shunaoxin dropping pill, a Chinese herb compound preparation, attenuates memory impairment in D-galactose-induced aging mice
- Protective effect of tetrahydropalmatine against d-galactose induced memory impairment in rat
- Piperine ameliorated memory impairment and myelin damage in lysolecethin induced hippocampal demyelination
- Treadmill exercise ameliorates chronic REM sleep deprivation-induced anxiety-like behavior and cognitive impairment in C57BL/6J mice
- Berberine ameliorates intrahippocampal kainate-induced status epilepticus and consequent epileptogenic process in the rat: Underlying mechanisms
- Identification of thyrotropin-releasing hormone as hippocampal glutaminyl cyclase substrate in neurons and reactive astrocytes
- Cajaninstilbene Acid Ameliorates Cognitive Impairment Induced by Intrahippocampal Injection of Amyloid-β1–42 Oligomers
- Minocycline ameliorates d-galactose-induced memory deficits and loss of Arc/Arg3.1 expression
- STAT3 ameliorates cognitive deficits by positively regulating the expression of NMDARs in a mouse model of FTDP-17
- Rifampicin ameliorates lithium-pilocarpine-induced seizures, consequent hippocampal damage and memory deficit in rats: Impact on oxidative, inflammatory and …
- Casticin ameliorates scopolamine-induced cognitive dysfunction in mice
- TGF-β1 restores hippocampal synaptic plasticity and memory in Alzheimer model via the PI3K/Akt/Wnt/β-catenin signaling pathway
- Receptor for complement peptide C3a: a therapeutic target for neonatal hypoxic‐ischemic brain injury
- Procognitive effect of AC-3933 in aged mice, and synergistic effect of combination with donepezil in scopolamine-treated mice
- Selenofuranoside improves long-term memory deficits in rats after exposure to monosodium glutamate: Involvement of Na+, K+-ATPase activity
- Effect of Codonopsis lanceolata with steamed and fermented process on scopolamine-induced memory impairment in mice
- Bacopaside I ameliorates cognitive impairment in APP/PS1 mice via immune-mediated clearance of β-amyloid
- Effect of Berberine Chloride on Long Term Potentiation (LTP) at Dentate Gyrus in Streptozotocin-Induced Diabetic Rats
- Berberine protects against memory impairment and anxiogenic-like behavior in rats submitted to sporadic Alzheimer’s-like dementia: involvement of …
- STAT3 ameliorates cognitive deficits via regulation of NMDAR expression in an Alzheimer’s disease animal model
- Inhibition of glutaminyl cyclase ameliorates amyloid pathology in an animal model of Alzheimer’s disease via the modulation of γ-secretase activity
- Berberine improves cognitive impairment by promoting autophagic clearance and inhibiting production of β-amyloid in APP/tau/PS1 mouse model of Alzheimer’s …
- Effect of hachimijiogan on memory impairment induced by beta‐amyloid combined with cerebral ischemia in rats
- A natural BACE1 and GSK3β dual inhibitor Notopterol effectively ameliorates the cognitive deficits in APP/PS1 Alzheimer’s mice by attenuating amyloid‐β and …
- Autophagy impairment by caspase‐1‐dependent inflammation mediates memory loss in response to β‐Amyloid peptide accumulation
- Interferon beta ameliorates cognitive dysfunction in a rat model of Alzheimer’s disease: Modulation of hippocampal neurogenesis and apoptosis as underlying …
- Dietary astaxanthin can accumulate in the brain of rats
- Scutellarin Ameliorates Learning and Memory Deficit via Suppressing -Amyloid Formation and Microglial Activation in Rats with Chronic Cerebral Hypoperfusion
- Treadmill exercise prevents learning and memory impairment in Alzheimer’s disease-like pathology
- Lapatinib ditosylate rescues memory impairment in D-galactose/ovariectomized rats: Potential repositioning of an anti-cancer drug for the treatment of Alzheimer’s …
- Berberine ameliorates brain inflammation in poloxamer 407-induced hyperlipidemic rats
- Oral administration of gintonin attenuates cholinergic impairments by scopolamine, amyloid-β protein, and mouse model of Alzheimer’s disease
- Picrorhiza kurroa Prevents Memory Deficits by Inhibiting NLRP3 Inflammasome Activation and BACE1 Expression in 5xFAD Mice
- Neuroprotective effects of salvianolic acid B on an Aβ25–35 peptide-induced mouse model of Alzheimer’s disease
- CAPE-pNO2 ameliorates diabetic brain injury through modulating Alzheimer’s disease key proteins, oxidation, inflammation and autophagy via a Nrf2-dependent …
- Effects of propentofylline, a NGF synthesis stimulator, on alterations in muscarinic cholinergic receptors induced by basal forebrain lesion in rats
- Leonurine ameliorates D-galactose-induced aging in mice through activation of the Nrf2 signalling pathway
- The effect of ghrelin on MK-801 induced memory impairment in rats
- Swimming exercise improves cognitive and behavioral disorders in male NMRI mice with sporadic Alzheimer-like disease
- Anti-inflammaging effects of Lactobacillus brevis OW38 in aged mice
- The Impact of Bdnf Gene Deficiency to the Memory Impairment and Brain Pathology of APPswe/PS1dE9 Mouse Model of Alzheimer’s Disease
- Sirtuin-2 inhibition affects hippocampal functions and sodium butyrate ameliorates the reduction in novel object memory, cell proliferation, and neuroblast …
- Colivelin ameliorates impairments in cognitive behaviors and synaptic plasticity in APP/PS1 transgenic mice
- Neferine alleviates memory and cognitive dysfunction in diabetic mice through modulation of the NLRP3 inflammasome pathway and alleviation of endoplasmic …
- Inhibition of PDE2 reverses beta amyloid induced memory impairment through regulation of PKA/PKG-dependent neuro-inflammatory and apoptotic pathways
- Companion retards the development of memory deficit in APP/PS1 mice
- Glycyrrhiza and Uncaria Hook contribute to protective effect of traditional Japanese medicine yokukansan against amyloid β oligomer-induced neuronal death
- 1950 MHz electromagnetic fields ameliorate Aβ pathology in Alzheimer’s disease mice
- ADAM10 in Alzheimer’s disease: Pharmacological modulation by natural compounds and its role as a peripheral marker
- The KATP channel opener, nicorandil, ameliorates brain damage by modulating synaptogenesis after ischemic stroke
- The PDE4 inhibitor HT-0712 improves hippocampus-dependent memory in aged mice
- Effects of idebenone, a cerebral metabolism activator, on muricidal behavior in rats with raphe lesions
- Synaptic and memory dysfunction induced by tau oligomers is rescued by up-regulation of the nitric oxide cascade
- Butterbur leaves attenuate memory impairment and neuronal cell damage in amyloid beta-induced alzheimer’s disease models
- Medicinal plants and dementia therapy: herbal hopes for brain aging?
- Neuroprotective effects of INT-777 against Aβ1–42-induced cognitive impairment, neuroinflammation, apoptosis, and synaptic dysfunction in mice
- Silibinin alleviates the learning and memory defects in overtrained rats accompanying reduced neuronal apoptosis and senescence
- Ethanol Extract and Saponin of Platycodon grandiflorum Ameliorate Scopolamine-Induced Amnesia in Mice
- Berberine and neurodegeneration: A review of literature
- Role of gut-brain axis, gut microbial composition, and probiotic intervention in Alzheimer’s disease
- The effect of long-term environmental enrichment in chronic cerebral hypoperfusion-induced memory impairment in rats
- In vitro importance of probiotic Lactobacillus plantarum related to medical field
- Nitazoxanide, an anti-parasitic drug, efficiently ameliorates learning and memory impairments in AD model mice
- The multiple T-maze in vivo testing of the neuroprotective effect of humanin analogues
- Postsynaptic GluR2 involved in amelioration of Aβ-induced memory dysfunction by KAIXIN-San through rescuing hippocampal LTP in mice
- PDE5 exists in human neurons and is a viable therapeutic target for neurologic disease
- Possible Therapeutic Effect of Exercise for Incurable Diseases
- A soluble truncated tau species related to cognitive dysfunction is elevated in the brain of cognitively impaired human individuals
- Genistein prevents hypoxia-induced cognitive dysfunctions by ameliorating oxidative stress and inflammation in the hippocampus
- Green tea extract containing enhanced levels of epimerized catechins attenuates scopolamine-induced memory impairment in mice
- Metformin treatment prevents amyloid plaque deposition and memory impairment in APP/PS1 mice
- Ferulic acid inhibits neuro-inflammation in mice exposed to chronic unpredictable mild stress
- A synbiotic consisting of Lactobacillus plantarum S58 and hull-less barley β-glucan ameliorates lipid accumulation in mice fed with a high-fat diet by activating AMPK …
- A novel small Odorranalectin-bearing cubosomes: preparation, brain delivery and pharmacodynamic study on amyloid-β25–35-treated rats following intranasal …
- Suan-Zao-Ren Decoction ameliorates synaptic plasticity through inhibition of the Aβ deposition and JAK2/STAT3 signaling pathway in AD model of APP/PS1 …
- Caffeine reduces time-of-day effects on memory performance in older adults
- Chronic administration of Tat-GluR23Y ameliorates cognitive dysfunction targeting CREB signaling in rats with amyloid beta neurotoxicity
- The effects of betulinic acid on neurobehavioral activity, electrophysiology and histological changes in an animal model of the Alzheimer’s disease
- Arctigenin attenuates ischemic stroke via SIRT1-dependent inhibition of NLRP3 inflammasome
- Arctigenin attenuates learning and memory deficits through PI3k/Akt/GSK-3β pathway reducing tau hyperphosphorylation in Aβ-induced AD mice
- Lactobacilli-fermented cow’s milk attenuated lipopolysaccharide-induced neuroinflammation and memory impairment in vitro and in vivo
- Kaempferol attenuates cognitive deficit via regulating oxidative stress and neuroinflammation in an ovariectomized rat model of sporadic dementia
- Small molecule LX2343 ameliorates cognitive deficits in AD model mice by targeting both amyloid β production and clearance
- Epigallocatechin-3-gallate attenuates impairment of learning and memory in chronic unpredictable mild stress-treated rats by restoring hippocampal …
- Astaxanthin improved the cognitive deficits in APP/PS1 transgenic mice via selective activation of mTOR
- A novel prolyl endopeptidase inhibitor, JTP-4819, with potential for treating Alzheimer’s disease
- N-acetyl cysteine supplementation prevents impairment of spatial working memory functions in rats following exposure to hypobaric hypoxia
- Targeted inhibition of RAGE reduces amyloid-β influx across the blood-brain barrier and improves cognitive deficits in db/db mice
- Isoorientin improves scopolamine-induced cognitive impairments by restoring the cholinergic system, antioxidant defense, and p-CREB/BDNF signaling in the …
- HSF1/HSP pathway in the hippocampus is involved in SIRT1-mediated caloric restriction-induced neuroprotection after surgery in aged mice
- Amyloid-β causes memory impairment by disturbing the JAK2/STAT3 axis in hippocampal neurons
- Neuroprotective effects of salidroside administration in a mouse model of Alzheimer’s disease
- Intraperitoneal administration of a novel TAT-BDNF peptide ameliorates cognitive impairments via modulating multiple pathways in two Alzheimer’s rodent …
- Neuroprotective effects of berberine in animal models of Alzheimer’s disease: a systematic review of pre-clinical studies
- Ghrelin-mediated hippocampal neurogenesis: implications for health and disease
- Lactobacillus fermentum ZS40 Ameliorates Inflammation in Mice With Ulcerative Colitis Induced by Dextran Sulfate Sodium
- Cognitive dysfunctions induced by a cholinergic blockade and Aβ25–35 peptide are attenuated by salvianolic acid B
- Ameliorating effect of luteolin on memory impairment in an Alzheimer’s disease model
- Lactobacillus sakei OK67 ameliorates collagen-induced arthritis in mice by inhibiting NF-κB activation and restoring Th17/Treg cell balance
- Quercetin reverses hypobaric hypoxia-induced hippocampal neurodegeneration and improves memory function in the rat
- The molecular implications of a caspase-2-mediated site-specific tau cleavage in tauopathies
- rTMS Ameliorates Prenatal Stress–Induced Cognitive Deficits in Male-Offspring Rats Associated With BDNF/TrkB Signaling Pathway
- Tadalafil crosses the blood–brain barrier and reverses cognitive dysfunction in a mouse model of AD
- Prophylactic melatonin treatment ameliorated Propofol-Induced cognitive dysfunction in aged rats
- Recent insights into the biological activities and drug delivery systems of tanshinones
- CRISPR/Cas9-mediated CysLT1R deletion reverses synaptic failure, amyloidosis and cognitive impairment in APP/PS1 mice
- Amentoflavone Ameliorates Aβ1–42-Induced Memory Deficits and Oxidative Stress in Cellular and Rat Model
- The effect of fish oil on social interaction memory in total sleep-deprived rats with respect to the hippocampal level of stathmin, TFEB, synaptophysin and LAMP-1 …
- Donepezil inhibits the amyloid-beta oligomer-induced microglial activation in vitro and in vivo
- Plant natural products for cognitive impairment: A review of the preclinical evidence
- Calmodulin‐like skin protein protects against spatial learning impairment in a mouse model of Alzheimer disease
- Natural products targeting amyloid beta in Alzheimer’s disease
- Protective effect of atorvastatin on d-galactose-induced aging model in mice
- Effects of extracts from Cordyceps sinensis on M1 muscarinic acetylcholine receptor in vitro and in vivo
- Saponins from Panax japonicus attenuate D-galactose-induced cognitive impairment through its anti-oxidative and anti-apoptotic effects in rats
- Effect of the oral administration of nanoencapsulated quercetin on a mouse model of Alzheimer’s disease
- Theaflavins improve memory impairment and depression-like behavior by regulating microglial activation
- Simvastatin ameliorate memory deficits and inflammation in clinical and mouse model of Alzheimer’s disease via modulating the expression of miR-106b
- Phosphodiesterase inhibition in cognitive decline
- Cornel iridoid glycoside induces autophagy to protect against tau oligomer neurotoxicity induced by the activation of glycogen synthase kinase-3β
- Therapeutic effect of organoselenium dietary supplementation in a sporadic dementia of Alzheimer’s type model in rats
- Suppression of adiponectin receptor 1 promotes memory dysfunction and Alzheimer’s disease-like pathologies
- Lycopene-a pleiotropic neuroprotective nutraceutical: deciphering its therapeutic potentials in broad spectrum neurological disorders
- Neuroinflammatory response to experimental stroke is inhibited by eriodictyol
- Prebiotic Effect of Fructooligosaccharides from Morinda officinalis on Alzheimer’s Disease in Rodent Models by Targeting the Microbiota-Gut-Brain Axis
- Lactobacillus paracasei PS23 dietary supplementation alleviates muscle aging via ghrelin stimulation in d-galactose-induced aging mice
- The transcription factor Sp3 cooperates with HDAC2 to regulate synaptic function and plasticity in neurons
- Inhibition of phosphodiesterase-4 reverses memory deficits produced by Aβ25–35 or Aβ1–40 peptide in rats
- Effect of a novel prolyl endopeptidase inhibitor, JTP-4819, on spatial memory and on cholinergic and peptidergic neurons in rats with ibotenate-induced lesions of the …
- Physical exercise prevents motor disorders and striatal oxidative imbalance after cerebral ischemia-reperfusion
- A dual inhibitor of the proteasome catalytic subunits LMP2 and Y attenuates disease progression in mouse models of Alzheimer’s disease
- Berberine neuroprotection and antioxidant activity
- The ameliorating effect of the extract of the flower of Prunella vulgaris var. lilacina on drug-induced memory impairments in mice
- NEURAL EFFECTS OF THE PROLACTIN/VASOINHIBIN AXIS
- The mechanistic target of rapamycin (mTOR) and the silent mating-type information regulation 2 homolog 1 (SIRT1): Oversight for neurodegenerative disorders
- Influence of Asafoetida on Prevention and Treatment of Memory Impairment Induced by d-Galactose and NaNO2 in Mice
- Phosphodiesterase: an interface connecting cognitive deficits to neuropsychiatric and neurodegenerative diseases
- The effect of nimodipine on memory impairment during spontaneous morphine withdrawal in mice: Corticosterone interaction
- Ameliorative effects of apple cider vinegar on neurological complications via regulation of oxidative stress markers
- Semaglutide-mediated protection against Aβ correlated with enhancement of autophagy and inhibition of apotosis
- Alpha-tocopherol in the brain tissue preservation of stroke-prone spontaneously hypertensive rats
- Impact of interval training with probiotic (L. plantarum/Bifidobacterium bifidum) on passive avoidance test, ChAT and BDNF in the hippocampus of rats with Alzheimer’s …
- A Becn1 mutation mediates hyperactive autophagic sequestration of amyloid oligomers and improved cognition in Alzheimer’s disease
- Amyrin attenuates scopolamine-induced cognitive impairment in mice
- Neuroprotective effect of ligustilide through induction of α-secretase processing of both APP and Klotho in a mouse model of Alzheimer’s disease
- Probiotic mixture KF attenuates age-dependent memory deficit and lipidemia in Fischer 344 rats
- Sulfated polysaccharide isolated from the nacre of pearl oyster improves scopolamine-induced memory impairment
- Nobiletin protects dopaminergic neurons in the 1-methyl-4-phenylpyridinium-treated rat model of Parkinson’s disease
- H2S Attenuates Sleep Deprivation-Induced Cognitive Impairment by Reducing Excessive Autophagy via Hippocampal Sirt-1 in WISTAR RATS
- Protective effect of Centella asiatica against D-galactose and aluminium chloride induced rats: Behavioral and ultrastructural approaches
- Amyloid-β peptide impact on synaptic function and neuroepigenetic gene control reveal new therapeutic strategies for Alzheimer’s disease
- A recent overview on the biological and pharmacological activities of ferulic acid
- Oroxylin A improves attention deficit hyperactivity disorder-like behaviors in the spontaneously hypertensive rat and inhibits reuptake of dopamine in vitro
- Fisetin enhances behavioral performances and attenuates reactive gliosis and inflammation during aluminum chloride-induced neurotoxicity
- Optimized-SopungSunkiwon, a Herbal Formula, Attenuates Aβ Oligomer-Induced Neurotoxicity in Alzheimer’s Disease Models
- Sesamin alleviates diabetes-associated behavioral deficits in rats: The role of inflammatory and neurotrophic factors
- Synaptic and Memory Dysfunction Induced by Tau Oligomers is Rescued by Up-regulation of the Nitric Oxide Cascade
- Memory Impairment in A?'(25-35) and D-Galactose Induced Alzheimer’s Disease Model Rat
- Pharmacological targeting of MCL-1 promotes mitophagy and improves disease pathologies in an Alzheimer’s disease mouse model
- Sildenafil protects neuronal cells from mitochondrial toxicity induced by β-amyloid peptide via ATP-sensitive K+ channels
- In vitro antioxidant activities of proanthocyanidins extracted from the lotus seedpod and ameliorative effects on learning and memory impairment in scopolamine …
- Tanshinone IIA attenuates Aβ25–35-induced spatial memory impairment via upregulating receptors for activated C kinase1 and inhibiting autophagy in hippocampus
- Neuroprotective effect of forsythiaside against transient cerebral global ischemia in gerbil
- Voluntary wheel running improves spatial learning memory by suppressing inflammation and apoptosis via inactivation of nuclear factor kappa B in brain …
- Natural products as modulators of the proteostasis machinery: implications in neurodegenerative diseases
- LX2343 alleviates cognitive impairments in AD model rats by inhibiting oxidative stress-induced neuronal apoptosis and tauopathy
- An adenoviral vector encoded with the GPx-1 gene attenuates memory impairments induced by β-amyloid (1-42) in GPx-1 KO mice via activation of M1 mAChR …
- Probiotic Lactobacillus fermentum strain JDFM216 improves cognitive behavior and modulates immune response with gut microbiota
- Phosphodiesterase type 5 (PDE5) inhibition improves object recognition memory: indications for central and peripheral mechanisms
- Amentoflavone suppresses amyloid β1–42 neurotoxicity in Alzheimer’s disease through the inhibition of pyroptosis
- Ellagic acid protects against diabetes-associated behavioral deficits in rats: Possible involved mechanisms
- Effects and mechanisms of natural products on Alzheimer’s disease
- Traditional Korean East Asian medicines and herbal formulations for cognitive impairment
- Chronic alpha-linolenic acid treatment alleviates age-associated neuropathology: roles of PERK/eIF2α signaling pathway
- Lactobacillus sakei OK67 ameliorates high-fat diet–induced blood glucose intolerance and obesity in mice by inhibiting gut microbiota lipopolysaccharide production …
- PNU282987 alleviates Aβ-induced anxiety and depressive-like behaviors through upregulation of α7nAChR by ERK-serotonin receptors pathway
- Pulmonary B cells ameliorate Alzheimer’s disease-like neuropathology
- Goat milk attenuates mimetic aging related memory impairment via suppressing brain oxidative stress, neurodegeneration and modulating neurotrophic factors in d …
- Valproic acid alleviates memory deficits and attenuates amyloid-β deposition in transgenic mouse model of Alzheimer’s disease
- Anti-aging effect of the combination of Bifidobacterium longum and B. animalis in a d-galactose-treated mice
- Atorvastatin ameliorates depressive behaviors and neuroinflammatory in streptozotocin-induced diabetic mice
- Effect of delta opioid receptor activation on spatial cognition and neurogenesis in cerebral ischemic rats
- Polysaccharides from Tetrastigma hemsleyanum Diels et Gilg: extraction optimization, structural characterizations, antioxidant and antihyperlipidemic activities in …
- Dinitrobenzene sulphonic acid-induced colitis impairs spatial recognition memory in mice: roles of N-methyl D-aspartate receptors and nitric oxide
- Whole body vibration training improves depression-like behaviors in a rat chronic restraint stress model
- Natural products as a source of Alzheimer’s drug leads
- Roles of multiple lipid mediators in stress and depression
- Traditional Chinese medicine-based neurorestorative therapy for Alzheimer’s and Parkinson’s disease
- Danshen diversity defeating dementia
- Green tea polyphenols improve isoflurane-induced cognitive impairment via modulating oxidative stress
- Flavonoid-rich ethanol extract from the leaves of Diospyros kaki attenuates cognitive deficits, amyloid-beta production, oxidative stress, and neuroinflammation in APP …
- Metabolic profiling of the effects of ginsenoside Re in an Alzheimer’s disease mouse model
- Cognitive-enhancing herbal formulae in Korean medicine: identification of candidates by text mining and literature review
- Treadmill exercise enhances motor coordination and ameliorates Purkinje cell loss through inhibition on astrocyte activation in the cerebellum of methimazole …
- Protein hydrolysate of silkworm pupa prevents memory impairment induced by oxidative stress in scopolamine-induced mice via modulating the cholinergic …
- ERK activation by zeranol has neuroprotective effect in cerebral ischemia reperfusion
- An optimized combination of ginger and peony root effectively inhibits amyloid-β accumulation and amyloid-β-mediated pathology in AβPP/PS1 double-transgenic …
- Spermidine, an autophagy inducer, as a therapeutic strategy in neurological disorders
- Notopterygium incisum extract (NRE) rescues cognitive deficits in APP/PS1 Alzhneimer’s disease mice by attenuating amyloid-beta, tau, and neuroinflammation …
- Fingolimod limits acute Aβ neurotoxicity and promotes synaptic versus extrasynaptic NMDA receptor functionality in hippocampal neurons
- Preadministration of high-dose alpha-tocopherol improved memory impairment and mitochondrial dysfunction induced by proteasome inhibition in rat hippocampus
- Dl-3-n-butylphthalide regulates cholinergic dysfunction in chronic cerebral hypoperfusion rats
- Targeting the JAK2/STAT3 axis in Alzheimer’s disease
- Potential effects of current drug therapies on cognitive impairment in patients with type 2 diabetes
- Neuroprotective effects of berberine in animal models of Alzheimer’s disease: a systematic review of pre-clinical studies
- Gastrodin attenuates bilateral common carotid artery occlusion-induced cognitive deficits via regulating Aβ-related proteins and reducing autophagy and …
- Lactobacillus brevis OK56 ameliorates high-fat diet-induced obesity in mice by inhibiting NF-κB activation and gut microbial LPS production
- Dysfunctional autophagy and endolysosomal system in neurodegenerative diseases: relevance and therapeutic options
- The Protective Effects of Gardenia jasminoides (Fructus Gardenia) on Amyloid-β-Induced Mouse Cognitive Impairment and Neurotoxicity
- The memory-enhancing effects of 7, 8, 4′-trihydroxyisoflavone, a major metabolite of daidzein, are associated with activation of the cholinergic system and BDNF …
- Alzheimers’ disease and epilepsy: a literature review
- Royal jelly alleviates cognitive deficits and β-amyloid accumulation in APP/PS1 mouse model via activation of the cAMP/PKA/CREB/BDNF pathway and …
- Extensive intestinal first-pass metabolism of arctigenin: evidenced by simultaneous monitoring of both parent drug and its major metabolites
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- A novel prolyl endopeptidase inhibitor, JTP-4819-its behavioral and neurochemical properties for the treatment of Alzheimer’s disease
- Journal of Molecular Biomarkers & Diagnosis
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- Tadalafil enhances working memory, and reduces hippocampal oxidative stress in both young and aged mice
- Peripheral nerve injury leads to working memory deficits and dysfunction of the hippocampus by upregulation of TNF-α in rodents
- 5-Aroylindoles act as selective histone deacetylase 6 inhibitors ameliorating Alzheimer’s disease phenotypes
- Gut microbiome and behavior: focus on neuroimmune interactions
- Phosphorylation and antiaging activity of polysaccharide from Trichosanthes peel
- Effects of putative cognitive function-enhancing drugs and dopaminergic agents on somatostatin and neuropeptide Y in rat brain
- Platycodon grandiflorus Root Extract Improves Learning and Memory by Enhancing Synaptogenesis in Mice Hippocampus
- Wheat embryo globulin nutrients ameliorate d-galactose and aluminum chloride-induced cognitive impairment in rats
- Berberine chloride improved synaptic plasticity in STZ induced diabetic rats
- Berberine attenuates convulsing behavior and extracellular glutamate and aspartate changes in 4-aminopyridine treated rats
- Anti-Alzheimer properties of probiotic, Lactobacillus plantarum MTCC 1325 in Alzheimer’s disease induced albino rats
- Role of berberine in Alzheimer’s disease
- Heat shock protein signaling in brain ischemia and injury
- Humanin and the receptors for humanin
- Effect of glycyrrhizic acid on scopolamine-induced cognitive impairment in mice
- Resveratrol in Alzheimer’s disease: a review of pathophysiology and therapeutic potential
- Protective effect of exercise and sildenafil on acute stress and cognitive function
- Modulation of hippocampal TLR4/BDNF signal pathway using probiotics is a step closer towards treating cognitive impairment in NASH model
- The pharmacological activity of epigallocatechin-3-gallate (EGCG) on Alzheimer’s disease animal model: A systematic review
- Chronic ethanol exposure induced depressive-like behavior in male C57BL/6 N mice by downregulating GluA1
- Evaluation of anti-amnesic effect of extracts of selected Ocimum species using in-vitro and in-vivo models
- Protective effects of Humanin and calmodulin-like skin protein in Alzheimer’s disease and broad range of abnormalities
- Pulmonary B Lymphocytes Ameliorate Alzheimer’s Disease-Like Neuropathology
- Ameliorative effects of a cognitive enhancer, T-588, on place learning deficits induced by transient forebrain ischemia in rats
- Female-dependent impaired fear memory of adult rats induced by maternal separation, and screening of possible related genes in the hippocampal CA1
- Effects of Piperine Pretreatment on Antioxidant Capacity and Spatial Memory Impairment Induced by Local Injection of Lysolecethin in Rat Hippocampus
- Modulation of hippocampal dopamine and synapse-related proteins by electroacupuncture improves memory deficit caused by sleep deprivation
- A Status Report on Autonomic Nervous System: The Indian Research Scenario During the Last Five Years
- The inhibitory effect of chitosan oligosaccharides on β-site amyloid precursor protein cleaving enzyme 1 (BACE1) in HEK293 APPswe cells
- Screening inducers of neuronal BDNF gene transcription using primary cortical cell cultures from BDNF-luciferase transgenic mice
- Tadalafil versus linaclotide in gastrointestinal dysfunction and depressive behavior in constipation–predominant irritable bowel syndrome
- Preventive action of Kai Xin San aqueous extract on depressive-like symptoms and cognition deficit induced by chronic mild stress
- Cognitive enhancing effect of diapocynin in D-galactose-ovariectomy-induced Alzheimer’s-like disease in rats: Role of ERK, GSK-3β, and JNK signaling
- Gut flora-targeted photobiomodulation therapy improves senile dementia in an Aß-induced Alzheimer’s disease animal model
- Hydrogen sulfide-mediated regulation of cell death signaling ameliorates adverse cardiac remodeling and diabetic cardiomyopathy
- Effect of Wuling powder on the pharmacokinetics of valproic acid in epileptic rats
- Flavonoids with potential anti-amyloidogenic effects as therapeutic drugs for treating Alzheimer’s disease
- Echinacoside suppresses amyloidogenesis and modulates F-actin remodeling by targeting the ER stress sensor PERK in a mouse model of Alzheimer’s …
- Differential expression levels of the hippocampal ghrelin and its receptor mRNA during memory consolidation
- PERK as a hub of multiple pathogenic pathways leading to memory deficits and neurodegeneration in Alzheimer’s disease
- Enteromorpha prolifera Extract Improves Memory in Scopolamine-Treated Mice via Downregulating Amyloid-β Expression and Upregulating BDNF/TrkB Pathway
- Protective effect of low dose caffeine on psychological stress and cognitive function
- Tanshinone I alleviates motor and cognitive impairments via suppressing oxidative stress in the neonatal rats after hypoxic-ischemic brain damage
- Traditional oriental medicines and Alzheimer’s disease
- Muscarinic agonists for the treatment of cognition in schizophrenia
- The protective effect of zeranol in cerebral ischemia reperfusion via p-CREB overexpression
- Lactobacillus plantarum PS128 prevents cognitive dysfunction in Alzheimer’s disease mice by modulating propionic acid levels, glycogen synthase kinase 3 …
- Hesperetin confers neuroprotection by regulating Nrf2/TLR4/NF-κB signaling in an Aβ mouse model
- Protective role of apigenin against Aβ 25–35 toxicity via inhibition of mitochondrial cytochrome c release
- Efficacy and safety of traditional Chinese medicine on thromboembolic events in patients with atrial fibrillation: a systematic review and meta-analysis
- Fyn deficiency attenuates renal fibrosis by inhibition of phospho-STAT3
- Potential enzymatic targets in Alzheimer’s: a comprehensive review
- Ethanol extract of the seed of Zizyphus jujuba var. spinosa potentiates hippocampal synaptic transmission through mitogen-activated protein kinase, adenylyl cyclase …
- A microRNA signature that correlates with cognition and is a target against cognitive decline
- Selective targeting of non-nuclear estrogen receptors with PaPE-1 as a new treatment strategy for Alzheimer’s disease
- The role of sodium hydrosulfide in attenuating the aging process via PI3K/AKT and CaMKKβ/AMPK pathways
- A novel strain of Lactobacillus mucosae isolated from a Gaotian villager improves in vitro and in vivo antioxidant as well as biological properties in d-galactose …
- The impact of vitamin E and other fat-soluble vitamins on Alzheimer s disease
- Tripchlorolide may improve spatial cognition dysfunction and synaptic plasticity after chronic cerebral hypoperfusion
- Antidiabetic polypill improves central pathology and cognitive impairment in a mixed model of Alzheimer’s disease and type 2 diabetes
- Green tea epigallocatechin-3-gallate (EGCG) targeting protein misfolding in drug discovery for neurodegenerative diseases
- Dried plum and chokeberry ameliorate d-galactose-induced aging in mice by regulation of Pl3k/Akt-mediated Nrf2 and Nf-kB pathways
- Prevention of the brain neurodegeneration in rats with experimental Alzheimer’s disease by adaptation to hypoxia
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- Probiotics for preventing cognitive impairment in Alzheimer’s disease
- Effective suppression of nitric oxide production by HX106N through transcriptional control of heme oxygenase-1
- Inconsistent effects of sleep deprivation on memory function
- In vitro binding and in vivo biodistribution studies of the neuroprotective peptide humanin using [125I] humanin derivatives
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- Suppression of gut dysbiosis by Bifidobacterium longum alleviates cognitive decline in 5XFAD transgenic and aged mice
- Therapeutic Efficacy of Fenugreek Extract or/and Choline with Docosahexaenoic Acid in Attenuating Learning and Memory Deficits in Ovariectomized Rats.
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- The effects of Nigella sativa on neural damage after pentylenetetrazole induced seizures in rats
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- Berberis vulgaris and its constituent berberine as antidotes and protective agents against natural or chemical toxicities
- Ginger improves cognitive function via NGF-induced ERK/CREB activation in the hippocampus of the mouse
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- New perspectives of Lactobacillus plantarum as a probiotic: The gut-heart-brain axis
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- Probiotics: An Adjuvant therapy for D-Galactose induced Alzheimer’s disease
- Natural phytochemicals in the treatment and prevention of dementia: An overview
- Vitamin B6 prevents cognitive impairment in experimental pneumococcal meningitis
- Neuroprotective effects of NDEELNK from sea cucumber ovum against scopolamine-induced PC12 cell damage through enhancing energy metabolism and …
- Ghrelin attenuates depressive-like behavior, heart failure, and neuroinflammation in postmyocardial infarction rat model
- Melatonin improves cognitive deficits via restoration of cholinergic dysfunction in a mouse model of scopolamine-induced amnesia
- The antioxidant effects of whey protein peptide on learning and memory improvement in aging mice models
- Investigating the effect of ghrelin on improving memory and learning ability in animals: A systematic review
- Unifi nootropics from the lab to the web: a story of academic (and industrial) shortcomings
- Alterations in the CNS effects of anti-epileptic drugs by Chinese herbal medicines
- The role of G protein-coupled estrogen receptor 1 on neurological disorders
- Hydroalcoholic extract from Abelmoschus manihot (Linn.) Medicus flower reverses sleep deprivation-evoked learning and memory deficit
- Neuraminidase-inhibition Activity of Nodakenetin from Gongjin-dan Fermented by Lactic Acid Bacteria
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- Effects of dietary glucocerebrosides from sea cucumber on the brain sphingolipid profiles of mouse models of Alzheimer’s disease
- Investigating the effect of crocin on memory deficits induced by total sleep deprivation (TSD) with respect to the BDNF, TrkB and ERK levels in the hippocampus of …
- Protopanaxadiol derivative DDPU improves behavior and cognitive deficit in AD mice involving regulation of both ER stress and autophagy
- Soursop fruit extract mitigates scopolamine-induced amnesia and oxidative stress via activating cholinergic and Nrf2/HO-1 pathways
- Tanshinone IIA alleviates CCL2-induced leaning memory and cognition impairment in rats: A potential therapeutic approach for HIV-associated …
- Sphingolipids in foodstuff: Compositions, distribution, digestion, metabolism and health effects–A comprehensive review
- New insights into the pathogenesis of Alzheimer’s disease
- A novel rat model of fatty organ degeneration induced by poloxamer 407
- New Results on the Pharmacology and Clinical Use of the TCM-Drug Salvia miltiorrhiza
- Euxanthone Attenuates Aβ1–42-Induced Oxidative Stress and Apoptosis by Triggering Autophagy
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- miR-124 downregulates BACE 1 and alters autophagy in APP/PS1 transgenic mice
- Quercetin regulates the integrated stress response to improve memory
- The role of amygdala-based caspase-1 activation in regulating the behavioral response to allostatic stress
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- Treadmill exercise improves motor function and short-term memory by enhancing synaptic plasticity and neurogenesis in photothrombotic stroke mice
- Poria cocos polysaccharide attenuates damage of nervus in Alzheimer’s disease rat model induced by D-galactose and aluminum trichloride
- Icariside II effectively reduces spatial learning and memory impairments in Alzheimer’s disease model mice targeting beta-amyloid production
- Receptor-interacting protein kinase 1 (RIPK1) as a potential therapeutic target: an overview of its possible role in the pathogenesis of Alzheimer’s disease
- Role of D-galactose-induced brain aging and its potential used for therapeutic interventions
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- Disrupted hippocampal growth hormone secretagogue receptor 1α interaction with dopamine receptor D1 plays a role in Alzheimer′ s disease
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- Therapy of Dredging the Bowels Enhanced the Neuroprotective Effect of Nourishing Kidney Herbs on Hippocampal Cholinergic System in Alzheimer’s …
- Isolation and characterization of marker compounds from the leaves of allium cepa linn. and study of their biological activities
- DW14006 as a direct AMPKα1 activator improves pathology of AD model mice by regulating microglial phagocytosis and neuroinflammation
- Role of flavonoids in neurodegenerative diseases: Limitations and future perspectives
- Fecal microbiota transplantation alleviated Alzheimer’s disease-like pathogenesis in APP/PS1 transgenic mice
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- Notoginsenoside R1 improves cerebral ischemia/reperfusion injury by promoting neurogenesis via the BDNF/Akt/CREB pathway
- Angelica Sinensis Extract Protects Against Memory Deficits by Promoting P38 MAPK–mediated Hippocampal Neurogenesis and Neuronal Survival in the …
- Icariin, a major constituent of flavonoids from Epimedium brevicornum, protects against cognitive deficits induced by chronic brain hypoperfusion via its anti …
- Reconstituted mother tinctures of Gelsemium sempervirens L. improve memory and cognitive impairment in mice scopolamine-induced dementia model
- Sleep deprivation induces cognitive impairment by increasing blood-brain barrier permeability via CD44
- Peptide therapeutics in neurodegenerative disorders
- Neurotrophic peptides: potential drugs for treatment of amyotrophic lateral sclerosis and Alzheimer’s disease
- Wogonin increases β-amyloid clearance and inhibits tau phosphorylation via inhibition of mammalian target of rapamycin: potential drug to treat Alzheimer’s disease
- Acupuncture accelerates neural regeneration and synaptophysin production after neural stem cells transplantation in mice
- Saffron and neurological disorders
- Humanin; a defender against Alzheimer’s disease?
- Alzheimer’s disease animal models: elucidation of biomarkers and therapeutic approaches for cognitive impairment
- Alterations in brain-derived neurotrophic factor in the mouse hippocampus following acute but not repeated benzodiazepine treatment
- Natural products as modulator of autophagy with potential clinical prospects
- The protective effect of vanadium on cognitive impairment and the neuropathology of Alzheimer’s disease in APPSwe/PS1dE9 mice
- Gastric floating pill enhances the bioavailability and drug efficacy of dihydromyricetin in vivo
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- Ghrelin in Alzheimer’s disease: pathologic roles and therapeutic implications
- The potential of flavonoids for the treatment of neurodegenerative diseases
- Natural compounds with anti-BACE1 activity as promising therapeutic drugs for treating Alzheimerʼs disease
- The Neuroprotective Effects of Moderate Treadmill Exercise in a Rat Model of Alzheimer’s Disease
- Activation of α7 nicotinic acetylcholine receptor alleviates Aβ1-42-induced neurotoxicity via downregulation of p38 and JNK MAPK signaling pathways
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- Neuroprotective effect of Chunghyuldan from amyloid beta oligomer induced neuroinflammation in vitro and in vivo
- Diazepam and SL-327 synergistically attenuate anxiety-like behaviours in mice–Possible hippocampal MAPKs specificity
- Angelica sinensis extract promotes neuronal survival by enhancing p38 MAPK–mediated hippocampal neurogenesis and dendritic growth in the chronic phase of …
- Neuroprotective natural products for Alzheimer’s disease
- Nicotine Modulates Cognitive Function in D-Galactose-Induced Senescence in Mice
- Differential change in cortical and hippocampal monoamines, and behavioral patterns in streptozotocin-induced type 1 diabetic rats
- Chrysophanol improves memory ability of d-galactose and Aβ25–35 treated rat correlating with inhibiting tau hyperphosphorylation and the CaM–CaMKIV signal …
- Antioxidant and antimicrobial profile of chicken sausages prepared after fermentation of minced chicken meat with Lactobacillus plantarum and with additional …
- Aβ peptide secretion is reduced by Radix Polygalae‑induced autophagy via activation of the AMPK/mTOR pathway
- RETRACTED: Swimming exercise increases the level of nerve growth factor and stimulates neurogenesis in adult rat hippocampus
- Pyridoxine exerts antioxidant effects in cell model of Alzheimer’s disease via the Nrf-2/HO-1 pathway
- Ellagic acid: insights into its neuroprotective and cognitive enhancement effects in sporadic Alzheimer’s disease
- The effect and mechanism of 19S proteasome PSMD11/Rpn6 subunit in D-Galactose induced mimetic aging models
- mTOR: Driving apoptosis and autophagy for neurocardiac complications of diabetes mellitus
- Resistance exercise improves short-term memory through inactivation of NF-κB pathway in mice with Parkinson disease
- 5, 7-Dihydroxy-6-methoxy-4′-phenoxyflavone, a derivative of oroxylin A improves attention-deficit/hyperactivity disorder (ADHD)-like behaviors in spontaneously …
- S100A8/A9 drives neuroinflammatory priming and protects against anxiety-like behavior after sepsis
- Brain food for Alzheimer-free ageing: focus on herbal medicines
- Physical exercise during pregnancy prevents cognitive impairment induced by amyloid-β in adult offspring rats
- Autophagic activity in neuronal cell death
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- Modulation of the MAPKs pathways affects Aβ-induced cognitive deficits in Alzheimer’s disease via activation of α7nAChR
- Quercetin exhibits α7nAChR/Nrf2/HO-1-mediated neuroprotection against STZ-induced mitochondrial toxicity and cognitive impairments in experimental rodents
- The antidepressant-like effects of Danggui Buxue Decoction in GK rats by activating CREB/BDNF/TrkB signaling pathway
- Inhibition of heat shock protein 90 by 17-AAG reduces inflammation via P2X7 receptor/NLRP3 inflammasome pathway and increases neurogenesis after …
- Autophagy in Alzheimer’s disease
- Phytoconstituents and their Possible Mechanistic Profile for Alzheimer’s Disease–A Literature Review
- Aβ regulation-based multitarget strategy for drug discovery against Alzheimer’s disease
- Hypothyroidism induces interleukin-1-dependent autophagy mechanism as a key mediator of hippocampal neuronal apoptosis and cognitive decline in postnatal rats
- Overview of the anti-inflammatory effects, pharmacokinetic properties and clinical efficacies of arctigenin and arctiin from Arctium lappa L
- Gerobiotics: probiotics targeting fundamental aging processes
- Dexmedetomidine Attenuates Hippocampal Damage and Improves Cognition by Up-Regulating Glyoxalase1 in APP/PS1 Mice
- Macrophage polarization induced by probiotic bacteria: a concise review
- Dexpramipexole enhances hippocampal synaptic plasticity and memory in the rat
- Hops extract alleviates Aβ-injury to osteoblasts through antioxidant pathway
- An open-label, single-arm pilot study to evaluate the efficacy of daily low dose tadalafil on depression in patients with erectile dysfunction
- Beneficial Effects of Epigallocatechin-3-O-Gallate, Chlorogenic Acid, Resveratrol, and Curcumin on Neurodegenerative Diseases
- Novel phosphodiesterase type 5 modulators: a patent survey (2008–2010)
- Small molecule inhibitors of signal transducer and activator of transcription 3 (Stat3) protein
- The Protective Effects of Acer okamotoanum and Isoquercitrin on Obesity and Amyloidosis in a Mouse Model
- The molecular mechanisms of signal pathway activating effect of E2F-1/NF-κB/GSK-3β on cognitive dysfunction of Alzheimer rats
- Amyloid precursor protein regulates 5-fluorouracil resistance in human hepatocellular carcinoma cells by inhibiting the mitochondrial apoptotic pathway
- Effects of denial of reward through maternal contact in the neonatal period on adult hypothalamic–pituitary–adrenal axis function in the rat
- What’s new about crop plants: novel discoveries of the 21st century
- Arctigenin increases hemeoxygenase-1 gene expression by modulating PI3K/AKT signaling pathway in rat primary astrocytes
- Effect of amyloid toxicity or chronic cerebral hypoperfusion on brain insulin resistance in a rat model with intracerebroventricular streptozotocin
- Medicinal plants possessed beneficial therapeutic effects in Alzheimer’s disease and memory deficits
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- Hesperetin rescues emotional memory and synaptic plasticity deficit in aged rats.
- Transient bilateral common carotid artery occlusion (tBCCAO) of rats as a model of global cerebral ischemia
- The effects of Bisphenol-A, Zearalenoneand Arsenic on specific brain areas
- Protective effect of arctigenin on ethanol-induced neurotoxicity in PC12 cells
- [Gly14]-Humanin reduces histopathology and improves functional outcome after traumatic brain injury in mice
- NT-020, a natural therapeutic approach to optimize spatial memory performance and increase neural progenitor cell proliferation and decrease inflammation in the …
- Oxymatrine attenuates diabetes-associated cognitive deficits in rats
- Fluoxetine attenuated anxiety-like behaviors in streptozotocin-induced diabetic mice by mitigating the inflammation
- Chronic cerebral hypoperfusion induces vascular plasticity and hemodynamics but also neuronal degeneration and cognitive impairment
- miR‑134‑5p/Foxp2/Syn1 is involved in cognitive impairment in an early vascular dementia rat model
- Thymoquinone attenuates brain injury via an antioxidative pathway in a status epilepticus rat model
- Protective effects of kinetin against aluminum chloride and D-galactose induced cognitive impairment and oxidative damage in mouse
- Aqua-soluble DDQ reduces the levels of Drp1 and A β and inhibits abnormal interactions between A β and Drp1 and protects Alzheimer’s disease neurons from A β …
- Insulin signaling pathway and related molecules: role in neurodegeneration and Alzheimer’s disease
- Association of tea consumption with risk of Alzheimer’s disease and anti-beta-amyloid effects of tea
- Antioxidant, Anti-inflammatory and Anticholinergic action of berberine attenuates diabetic encephalopathy: Behavioral and Biochemical evidences
- Nanomedicine strategies for sustained, controlled and targeted treatment of Alzheimer’s disease
- Humanin inhibits neuronal cell death by interacting with a cytokine receptor complex or complexes involving CNTF receptor α/WSX-1/gp130
- Saikosaponin-d-mediated downregulation of neurogenesis results in cognitive dysfunction by inhibiting Akt/Foxg-1 pathway in mice
- Dexmedetomidine alleviates lipopolysaccharide-induced hippocampal neuronal apoptosis via inhibiting the p38 MAPK/c-Myc/CLIC4 signaling pathway in rats
- Molecular insight into the therapeutic promise of flavonoids against Alzheimer’s disease
- Atorvastatin modulates the expression of aging-related genes in the brain of aging induced by D-galactose in mice
- Signaling pathway cross talk in Alzheimer’s disease
- AMPA-receptor activation is involved in the antiamnesic effect of DM 232 (unifiram) and DM 235 (sunifiram)
- Recent progress in the role of autophagy in neurological diseases
- Elucidation of arctigenin pharmacokinetics and tissue distribution after intravenous, oral, hypodermic and sublingual administration in rats and beagle dogs …
- The green tea polyphenolic catechin epigallocatechin gallate and neuroprotection
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- Hippocampal extracellular signal-regulated kinase signaling has a role in passive avoidance memory retrieval induced by GABAA receptor modulation in …
- Valproic acid attenuates blood–brain barrier disruption in a rat model of transient focal cerebral ischemia: the roles of HDAC and MMP-9 inhibition
- The effect of agomelatine treatment on diabetes-induced cognitive impairments in rats: concomitant alterations in the hippocampal neuron numbers
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- Fluoxetine abolished psychological stress deleterious effect on memory in protein malnourished mice
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- Inhaled hydrogen sulfide prevents neurodegeneration and movement disorder in a mouse model of Parkinson’s disease
- Autophagy is involved in oral rAAV/Aβ vaccine-induced Aβ clearance in APP/PS1 transgenic mice
- Preventive effect of Coriandrum sativum on neuronal damages in pentylentetrazole-induced seizure in rats
- Effects of lacosamide treatment on epileptogenesis, neuronal damage and behavioral comorbidities in a rat model of temporal lobe epilepsy
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- Role of Lactobacillus plantarum MTCC1325 in membrane-bound transport ATPases system in Alzheimer’s disease-induced rat brain
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- 17-Allylamino-demethoxygeldanamycin ameliorate microthrombosis via HSP90/RIP3/NLRP3 pathway after subarachnoid hemorrhage in rats
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