(NRF2) (ACTIVATOR | ACTIVATORS | ACTIVATION)
December 8, 2023(SIRT1 | SIRT 1) (ACTIVATOR | ACTIVATORS | ACTIVATION)
December 8, 2023
- AMPK activation: a therapeutic target for type 2 diabetes?
- AMPK activators–potential therapeutics for metabolic and other diseases
- AMPK activation, a preventive therapeutic target in the transition from cardiac injury to heart failure
- Choreography of AMPK activation
- Use of cells expressing γ subunit variants to identify diverse mechanisms of AMPK activation
- Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome
- Effect of AMPK activation on muscle glucose metabolism in conscious rats
- AMP as a low-energy charge signal autonomously initiates assembly of AXIN-AMPK-LKB1 complex for AMPK activation
- A redox-dependent mechanism for regulation of AMPK activation by Thioredoxin1 during energy starvation
- Prognostic significance of AMPK activation and therapeutic effects of metformin in hepatocellular carcinoma
- Antileukemic effects of AMPK activators on BCR-ABL–expressing cells
- Anti-diabetic and anti-lipidemic effects of chlorogenic acid are mediated by ampk activation
- A small molecule AMPK activator protects the heart against ischemia–reperfusion injury
- SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function
- Hypoxia triggers AMPK activation through reactive oxygen species-mediated activation of calcium release-activated calcium channels
- Metformin amplifies chemotherapy-induced AMPK activation and antitumoral growth
- Berberine suppresses proinflammatory responses through AMPK activation in macrophages
- Activation of autophagy in human skeletal muscle is dependent on exercise intensity and AMPK activation
- Starvation-induced autophagy is regulated by mitochondrial reactive oxygen species leading to AMPK activation
- Predominant α2/β2/γ3 AMPK activation during exercise in human skeletal muscle
- Sestrin2 promotes LKB1-mediated AMPK activation in the ischemic heart
- Therapeutic metformin/AMPK activation blocked lymphoma cell growth via inhibition of mTOR pathway and induction of autophagy
- Berberine-induced apoptotic and autophagic death of HepG2 cells requires AMPK activation
- Suppression of AMPK activation via S485 phosphorylation by IGF-I during hyperglycemia is mediated by AKT activation in vascular smooth muscle cells
- Structural basis for AMPK activation: natural and synthetic ligands regulate kinase activity from opposite poles by different molecular mechanisms
- AMPK activator AICAR ameliorates ischaemia reperfusion injury in the rat kidney
- Gain-of-function mutant p53 promotes cell growth and cancer cell metabolism via inhibition of AMPK activation
- Structural basis of AMPK regulation by small molecule activators
- Chlorogenic acid stimulates glucose transport in skeletal muscle via AMPK activation: a contributor to the beneficial effects of coffee on diabetes
- Resveratrol promotes autophagic cell death in chronic myelogenous leukemia cells via JNK-mediated p62/SQSTM1 expression and AMPK activation
- AICAR, an AMPK activator, has protective effects on alcohol‐induced fatty liver in rats
- AMPK activation—protean potential for boosting healthspan
- Potential AMPK activators of cucurbitane triterpenoids from Siraitia grosvenorii Swingle
- Nilotinib induces autophagy in hepatocellular carcinoma through AMPK activation
- Resveratrol modulates tumor cell proliferation and protein translation via SIRT1-dependent AMPK activation
- AMP-activated protein kinase (AMPK) activators from Myristica fragrans (nutmeg) and their anti-obesity effect
- AMPK activation regulates neuronal structure in developing hippocampal neurons
- AMPK activation of muscle autophagy prevents fasting-induced hypoglycemia and myopathy during aging
- AMPK activation regulates apoptosis, adipogenesis, and lipolysis by eIF2α in adipocytes
- AMPK activators suppress cervical cancer cell growth through inhibition of DVL3 mediated Wnt/β-catenin signaling activity
- Berberine-induced AMPK activation inhibits the metastatic potential of melanoma cells via reduction of ERK activity and COX-2 protein expression
- Development of protein kinase activators: AMPK as a target in metabolic disorders and cancer
- AMPK activation stimulates autophagy and ameliorates muscular dystrophy in the mdx mouse diaphragm
- Hypoxia Leads to Na,K-ATPase Downregulation via Ca2+ Release-Activated Ca2+ Channels and AMPK Activation
- Exercise-induced AMPK activation does not interfere with muscle hypertrophy in response to resistance training in men
- AMPK activation is fiber type specific in human skeletal muscle: effects of exercise and short-term exercise training
- Crosstalk between AMPK activation and angiotensin II‐induced hypertrophy in cardiomyocytes: the role of mitochondria
- AMPK activation by glucagon-like peptide-1 prevents NADPH oxidase activation induced by hyperglycemia in adult cardiomyocytes
- Metformin inhibits P‐glycoprotein expression via the NF‐κB pathway and CRE transcriptional activity through AMPK activation
- AMPK activators as a drug for diabetes, cancer and cardiovascular disease
- Telmisartan prevention of LPS-induced microglia activation involves M2 microglia polarization via CaMKKβ-dependent AMPK activation
- A novel dual AMPK activator/mTOR inhibitor inhibits thyroid cancer cell growth
- Discovery and SAR development of thienopyridones: a class of small molecule AMPK activators
- Methotrexate promotes glucose uptake and lipid oxidation in skeletal muscle via AMPK activation
- AMPK activation promotes lipid droplet dispersion on detyrosinated microtubules to increase mitochondrial fatty acid oxidation
- AMPK activation ameliorates Alzheimer’s disease-like pathology and spatial memory impairment in a streptozotocin-induced Alzheimer’s disease model in rats
- A novel AMPK activator, WS070117, improves lipid metabolism discords in hamsters and HepG2 cells
- Exercise-induced irisin secretion is independent of age or fitness level and increased irisin may directly modulate muscle metabolism through AMPK activation
- Amelioration of LPS-induced inflammation response in microglia by AMPK activation
- SIRT3 reduces lipid accumulation via AMPK activation in human hepatic cells
- Novel small-molecule AMPK activator orally exerts beneficial effects on diabetic db/db mice
- AMPK activators inhibit the proliferation of human melanomas bearing the activated MAPK pathway
- AMPK activation through mitochondrial regulation results in increased substrate oxidation and improved metabolic parameters in models of diabetes
- Time course changes in signaling pathways and protein synthesis in C2C12 myotubes following AMPK activation by AICAR
- Resveratrol prevents AngII-induced hypertension via AMPK activation and RhoA/ROCK suppression in mice
- AMPK activation via modulation of de novo purine biosynthesis with an inhibitor of ATIC homodimerization
- Chronic AMPK activation evokes the slow, oxidative myogenic program and triggers beneficial adaptations in mdx mouse skeletal muscle
- AMPK activation stimulates myofibrillar protein degradation and expression of atrophy-related ubiquitin ligases by increasing FOXO transcription factors in C2C12 …
- AMPK activator, AICAR, inhibits palmitate-induced apoptosis in osteoblast
- … metabolic and oncogenic signaling pathways in triple-negative breast cancer by a novel adenosine monophosphate-activated protein kinase (AMPK) activator
- AMPK activation with glabridin ameliorates adiposity and lipid dysregulation in obesity
- Abnormalities of AMPK activation and glucose uptake in cultured skeletal muscle cells from individuals with chronic fatigue syndrome
- AMP ed up to treat prostate cancer: novel AMPK activators emerge for cancer therapy
- AMPK activation by isorhamnetin protects hepatocytes against oxidative stress and mitochondrial dysfunction
- Regulation of visceral and subcutaneous adipocyte lipolysis by acute AICAR‐induced AMPK activation
- Metformin attenuates pressure overload-induced cardiac hypertrophy via AMPK activation
- AMPK activation inhibits expression of proinflammatory mediators through downregulation of PI3K/p38 MAPK and NF-κB signaling in murine macrophages
- Palmitate causes endoplasmic reticulum stress and apoptosis in human mesenchymal stem cells: prevention by AMPK activator
- AMPK activation enhances PPARα activity to inhibit cardiac hypertrophy via ERK1/2 MAPK signaling pathway
- Survival advantage of AMPK activation to androgen-independent prostate cancer cells during energy stress
- AMPK activation prevents excess nutrient-induced hepatic lipid accumulation by inhibiting mTORC1 signaling and endoplasmic reticulum stress response
- AMPK activation inhibits the expression of HIF-1α induced by insulin and IGF-1
- Prognostic significance of AMPK activation in advanced stage colorectal cancer treated with chemotherapy plus bevacizumab
- Ursolic acid-induced AMP-activated protein kinase (AMPK) activation contributes to growth inhibition and apoptosis in human bladder cancer T24 cells
- Metformin induced AMPK activation, G0/G1 phase cell cycle arrest and the inhibition of growth of esophageal squamous cell carcinomas in vitro and in vivo
- Demethoxycurcumin inhibits energy metabolic and oncogenic signaling pathways through AMPK activation in triple-negative breast cancer cells
- Therapeutics by cytotoxic metabolite accumulation: pemetrexed causes ZMP accumulation, AMPK activation, and mammalian target of rapamycin inhibition
- Promotion of adiponectin multimerization by emodin: a novel AMPK activator with PPARγ‐agonist activity
- AICAR prevents heat-induced sudden death in RyR1 mutant mice independent of AMPK activation
- AMPK activation attenuates S6K1, 4E-BP1, and eEF2 signaling responses to high-frequency electrically stimulated skeletal muscle contractions
- Rutin increases muscle mitochondrial biogenesis with AMPK activation in high-fat diet-induced obese rats
- Antidiabetic effect of salvianolic acid A on diabetic animal models via AMPK activation and mitochondrial regulation
- Impaired muscle AMPK activation in the metabolic syndrome may attenuate improved insulin action after exercise training
- The AMPK activator R419 improves exercise capacity and skeletal muscle insulin sensitivity in obese mice
- AMPK activation can delay aging
- Monascin and ankaflavin act as natural AMPK activators with PPARα agonist activity to down-regulate nonalcoholic steatohepatitis in high-fat diet-fed C57BL/6 mice
- A crystallized view of AMPK activation
- Berberine improves kidney function in diabetic mice via AMPK activation
- Prolonged AMPK activation increases the expression of fatty acid transporters in cardiac myocytes and perfused hearts
- Increased skeletal muscle glucose uptake by rosemary extract through AMPK activation
- Exogenous cell-permeable C6 ceramide sensitizes multiple cancer cell lines to Doxorubicin-induced apoptosis by promoting AMPK activation and mTORC1 inhibition
- AMPK activation increases uncoupling protein‐3 expression and mitochondrial enzyme activities in rat muscle without fibre type transitions
- The hypotriglyceridemic effect of biotin supplementation involves increased levels of cGMP and AMPK activation
- Punicalagin, an active component in pomegranate, ameliorates cardiac mitochondrial impairment in obese rats via AMPK activation
- Compound K, intestinal metabolite of ginsenoside, attenuates hepatic lipid accumulation via AMPK activation in human hepatoma cells
- Synthesis and structure–activity relationship of berberine analogues in LDLR up-regulation and AMPK activation
- Methyl succinate antagonises biguanide‐induced AMPK‐activation and death of pancreatic β‐cells through restoration of mitochondrial electron transfer
- Docosahexaenoic acid induces cell death in human non-small cell lung cancer cells by repressing mTOR via AMPK activation and PI3K/Akt inhibition
- CTRP1 protein enhances fatty acid oxidation via AMP-activated protein kinase (AMPK) activation and acetyl-CoA carboxylase (ACC) inhibition
- Repression of protein synthesis and mTOR signaling in rat liver mediated by the AMPK activator aminoimidazole carboxamide ribonucleoside
- Ginsenoside Rg3 reduces lipid accumulation with AMP-activated protein kinase (AMPK) activation in HepG2 cells
- Utrophin A is essential in mediating the functional adaptations of mdx mouse muscle following chronic AMPK activation
- Small‑molecule COH-SR4 inhibits adipocyte differentiation via AMPK activation
- AMPK activation prevents prenatal stress-induced cognitive impairment: modulation of mitochondrial content and oxidative stress
- … crosstalk between the AMPK and PI3K/Akt pathways in breast cancer cells of differing genotypes: Leptin inhibits the effectiveness of AMPK activation
- Prostaglandin E2 promotes endothelial differentiation from bone marrow-derived cells through AMPK activation
- Sestrin2–AMPK activation protects mitochondrial function against glucose deprivation-induced cytotoxicity
- Thiacremonone, a sulfur compound isolated from garlic, attenuates lipid accumulation partially mediated via AMPK activation in 3T3-L1 adipocytes
- Exercise performance and peripheral vascular insufficiency improve with AMPK activation in high-fat diet-fed mice
- The effects of chronic AMPK activation on hepatic triglyceride accumulation and glycerol 3-phosphate acyltransferase activity with high fat feeding
- Acrp30 inhibits leptin-induced metastasis by downregulating the JAK/STAT3 pathway via AMPK activation in aggressive SPEC-2 endometrial cancer cells
- Ajoene, a stable garlic by-product, inhibits high fat diet-induced hepatic steatosis and oxidative injury through LKB1-dependent AMPK activation
- Sepsis and AMPK activation by AICAR differentially regulate FoxO-1,-3 and-4 mRNA in striated muscle
- Dieckol, a phlorotannin isolated from a brown seaweed, Ecklonia cava, inhibits adipogenesis through AMP-activated protein kinase (AMPK) activation in 3T3-L1 …
- AMPK activation by long chain fatty acyl analogs
- AMPK promotes skeletal muscle autophagy through activation of forkhead FoxO3a and interaction with Ulk1
- HCMV targets the metabolic stress response through activation of AMPK whose activity is important for viral replication
- Two triterpeniods from Cyclocarya paliurus (Batal) Iljinsk (Juglandaceae) promote glucose uptake in 3T3-L1 adipocytes: The relationship to AMPK activation
- Protective effect of nectandrin B, a potent AMPK activator on neointima formation: inhibition of Pin1 expression through AMPK activation
- Anti-obesity effects of ginsenoside Rh2 are associated with the activation of AMPK signaling pathway in 3T3-L1 adipocyte
- The antidiabetic drug metformin: a pharmaceutical AMPK activator to overcome breast cancer resistance to HER2 inhibitors while decreasing risk of cardiomyopathy
- Crude Extracts from Lycium barbarum Suppress SREBP-1c Expression and Prevent Diet-Induced Fatty Liver through AMPK Activation
- The serine/threonine kinase LKB1 controls thymocyte survival through regulation of AMPK activation and Bcl-XL expression
- A novel direct activator of AMPK inhibits prostate cancer growth by blocking lipogenesis
- Endothelium-dependent vasorelaxation to the AMPK activator AICAR is enhanced in aorta from hypertensive rats and is NO and EDCF dependent
- AICAR-dependent AMPK activation improves scar formation in the aged heart in a murine model of reperfused myocardial infarction
- High glucose-induced oxidative stress alters estrogen effects on ERα and ERβ in human endothelial cells: reversal by AMPK activator
- Genome-wide inhibitory impact of the AMPK activator metformin on [kinesins, tubulins, histones, auroras and polo-like kinases] M-phase cell cycle genes in human …
- AMPK activation by AICAR inhibits myogenic differentiation and myostatin expression in cattle
- Effects of pharmacological AMP deaminase inhibition and Ampd1 deletion on nucleotide levels and AMPK activation in contracting skeletal muscle
- Phosphorylation by Akt within the ST loop of AMPK-α1 down-regulates its activation in tumour cells
- AMPK-independent down-regulation of cFLIP and sensitization to TRAIL-induced apoptosis by AMPK activators
- Effects of α‐AMPK knockout on exercise‐induced gene activation in mouse skeletal muscle
- AMP-activated protein kinase (AMPK) activation inhibits nuclear translocation of Smad4 in mesangial cells and diabetic kidneys
- Activation of AMPK enhances neutrophil chemotaxis and bacterial killing
- AMPK activation by dihydrotestosterone reduces FSH-stimulated cell proliferation in rat granulosa cells by inhibiting ERK signaling pathway
- Anti-angiogenic effects of metformin, an AMPK activator, on human umbilical vein endothelial cells and on granulation tissue in rat
- Mitochondrial dysfunction represses HIF-1α protein synthesis through AMPK activation in human hepatoma HepG2 cells
- Early post-mortem AMP-activated protein kinase (AMPK) activation leads to phosphofructokinase-2 and-1 (PFK-2 and PFK-1) phosphorylation and the development of …
- Effects of AMPK Activation on Insulin Sensitivity and Metabolism in Leptin-Deficient ob/ob Mice
- Lovastatin induces multiple stress pathways including LKB1/AMPK activation that regulate its cytotoxic effects in squamous cell carcinoma cells
- AMPK activation is not critical in the regulation of muscle FA uptake and oxidation during low-intensity muscle contraction
- Prevention of high-fat diet-induced muscular lipid accumulation in rats by α lipoic acid is not mediated by AMPK activation [S]
- The antidiabetic effect of ginsenoside Rb2 via activation of AMPK
- Antiangiogenic effects of N6‐isopentenyladenosine, an endogenous isoprenoid end product, mediated by AMPK activation
- Metformin suppresses glucose-6-phosphatase expression by a complex I inhibition and AMPK activation-independent mechanism
- Activation of AMPK inhibits inflammation in MRL/lpr mouse mesangial cells
- … black carrots fermented with Aspergillus oryzae prevent the impairment of energy, lipid and glucose metabolism in estrogen-deficient rats by AMPK activation
- Fenofibric acid prevents retinal pigment epithelium disruption induced by interleukin-1β by suppressing AMP-activated protein kinase (AMPK) activation
- Identification of an annonaceous acetogenin mimetic, AA005, as an AMPK activator and autophagy inducer in colon cancer cells
- AMP‐activated protein kinase response to contractions and treatment with the AMPK activator AICAR in young adult and old skeletal muscle
- Beta-arrestin inhibits CAMKKbeta-dependent AMPK activation downstream of protease-activated-receptor-2
- Astragalus polysaccharide stimulates glucose uptake in L6 myotubes through AMPK activation and AS160/TBC1D4 phosphorylation
- Co-activation of AMPK and mTORC1 induces cytotoxicity in acute myeloid leukemia
- Anti-tumoral action of cannabinoids on hepatocellular carcinoma: role of AMPK-dependent activation of autophagy
- The AMPK-PPARGC1A pathway is required for antimicrobial host defense through activation of autophagy
- Activation of AMPK protects against hydrogen peroxide-induced osteoblast apoptosis through autophagy induction and NADPH maintenance: new implications for …
- Differential regulation of AMPK activation in leptin‐and creatine‐deficient mice
- Lessons from nature: sources and strategies for developing AMPK activators for cancer chemotherapeutics
- Activation of AMPK is essential for AICAR-induced glucose uptake by skeletal muscle but not adipocytes
- The stimulatory effect of essential fatty acids on glucose uptake involves both Akt and AMPK activation in C2C12 skeletal muscle cells
- Glioma-initiating cell elimination by metformin activation of FOXO3 via AMPK
- Pharmacological activation of AMPK prevents Drp1-mediated mitochondrial fission and alleviates endoplasmic reticulum stress-associated endothelial dysfunction
- Fluorinated N, N′-diarylureas as AMPK activators
- Effect of AMPK activation on monocarboxylate transporter (MCT) 1 and MCT4 in denervated muscle
- Sustained activation of AMPK ameliorates age-associated vascular endothelial dysfunction via a nitric oxide-independent mechanism
- Lipoprotein internalisation induced by oncogenic AMPK activation is essential to maintain glioblastoma cell growth
- Activation of the prolyl‐hydroxylase oxygen‐sensing signal cascade leads to AMPK activation in cardiomyocytes
- Erythropoietin contributes to slow oxidative muscle fiber specification via PGC-1α and AMPK activation
- Activation of AMPK stimulates heme oxygenase-1 gene expression and human endothelial cell survival
- Activation of AMP-activated protein kinase (AMPK) provides a metabolic barrier to reprogramming somatic cells into stem cells
- Ethanol extract of Cirsium japonicum attenuates hepatic lipid accumulation via AMPK activation in human HepG2 cells
- Oxidative stress improves coronary endothelial function through activation of the pro-survival kinase AMPK
- Curcumin attenuates hyperglycaemia-mediated AMPK activation and oxidative stress in cerebrum of streptozotocin-induced diabetic rat
- Down-regulation of amyloid-β through AMPK activation by inhibitors of GSK-3β in SH-SY5Y and SH-SY5Y-AβPP695 cells
- Imiquimod-induced AMPK activation causes translation attenuation and apoptosis but not autophagy
- Overexpression of AMP‐metabolizing enzymes controls adenine nucleotide levels and AMPK activation in HEK293T cells
- A novel AMPK activator from Chinese herb medicine and ischemia phosphorylate the cardiac transcription factor FOXO3
- Activation of AMP-activated protein kinase by metformin protects against global cerebral ischemia in male rats: interference of AMPK/PGC-1α pathway
- Chondrocyte autophagy is stimulated by HIF-1 dependent AMPK activation and mTOR suppression
- Effects of activation of AMPK on human breast cancer cell lines with different genetic backgrounds
- Salidroside ameliorates insulin resistance through activation of a mitochondria‐associated AMPK/PI3K/A kt/GSK 3β pathway
- Proteasome inhibitors induce AMPK activation via CaMKKβ in human breast cancer cells
- Rutaecarpine Analogues Reduce Lipid Accumulation in Adipocytes via Inhibiting Adipogenesis/Lipogenesis with AMPK Activation and UPR Suppression
- AMPK-induced activation of Akt by AICAR is mediated by IGF-1R dependent and independent mechanisms in acute lymphoblastic leukemia
- Reduction of lipid accumulation in HepG2 cells by luteolin is associated with activation of AMPK and mitigation of oxidative stress
- Transitory activation of AMPK at reperfusion protects the ischaemic-reperfused rat myocardium against infarction
- AMPK up-activation reduces motility and regulates other functions of boar spermatozoa
- Purinergic control of AMPK activation by ATP released through connexin 43 hemichannels–pivotal roles in hemichannel-mediated cell injury
- Wedelolactone regulates lipid metabolism and improves hepatic steatosis partly by AMPK activation and up-regulation of expression of PPARα/LPL and …
- Metformin reduces cisplatin-mediated apoptotic death of cancer cells through AMPK-independent activation of Akt
- Adiponectin blocks interleukin-18-mediated endothelial cell death via APPL1-dependent AMP-activated protein kinase (AMPK) activation and IKK/NF-κB …
- AMP-activated Protein Kinase (AMPK) Activation and Glycogen Synthase Kinase-3β (GSK-3β) Inhibition Induce Ca2+-independent Deposition of Tight …
- AMPK activation reduces vascular permeability and airway inflammation by regulating HIF/VEGFA pathway in a murine model of toluene diisocyanate-induced asthma
- SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function
- AMPK activator-mediated inhibition of endoplasmic reticulum stress ameliorates carrageenan-induced insulin resistance through the suppression of selenoprotein P …
- AMPK activation as a strategy for reversing the endothelial lipotoxicity underlying the increased vascular risk associated with insulin resistance syndrome
- Activation of AMPK inhibits cardiomyocyte hypertrophy by modulating of the FOXO1/MuRF1 signaling pathway in vitro
- Central acylated ghrelin improves memory function and hippocampal AMPK activation and partly reverses the impairment of energy and glucose metabolism in rats …
- Long-term forskolin stimulation induces AMPK activation and thereby enhances tight junction formation in human placental trophoblast BeWo cells
- Uncoupling protein 1 expression in murine skeletal muscle increases AMPK activation, glucose turnover, and insulin sensitivity in vivo
- Neuronal protein tyrosine phosphatase 1B deficiency results in inhibition of hypothalamic AMPK and isoform-specific activation of AMPK in peripheral tissues
- In vivo correction of COX deficiency by activation of the AMPK/PGC-1α axis
- Salicylate improves macrophage cholesterol homeostasis via activation of Ampk
- Metformin inhibits monocyte-to-macrophage differentiation via AMPK-mediated inhibition of STAT3 activation: potential role in atherosclerosis
- Green tea extract rich in epigallocatechin-3-gallate prevents fatty liver by AMPK activation via LKB1 in mice fed a high-fat diet
- Belinostat-induced apoptosis and growth inhibition in pancreatic cancer cells involve activation of TAK1-AMPK signaling axis
- Nutrient deprivation induces the Warburg effect through ROS/AMPK-dependent activation of pyruvate dehydrogenase kinase
- Metformin inhibition of mTORC1 activation, DNA synthesis and proliferation in pancreatic cancer cells: dependence on glucose concentration and role of AMPK
- Alteration of splice site selection in the LMNA gene and inhibition of progerin production via AMPK activation
- High molecular weight adiponectin activates AMPK and suppresses cytokine-induced NF-κB activation in vascular endothelial cells
- Mutant TDP-43 deregulates AMPK activation by PP2A in ALS models
- Activation of AMPK inhibits pulmonary arterial smooth muscle cells proliferation
- Fenoterol inhibits LPS-induced AMPK activation and inflammatory cytokine production through β-arrestin-2 in THP-1 cell line
- Activation of AMPK and its impact on exercise capacity
- Rho-kinase inhibition ameliorates metabolic disorders through activation of AMPK pathway in mice
- GSK3β-dependent inhibition of AMPK potentiates activation of neutrophils and macrophages and enhances severity of acute lung injury
- The AMPK agonist AICAR inhibits TGF-β1 induced activation of kidney myofibroblasts
- Activation of AMPK attenuates lipopolysaccharide-impaired integrity and function of blood–brain barrier in human brain microvascular endothelial cells
- Sorafenib synergizes with metformin in NSCLC through AMPK pathway activation
- Enhanced activation of cellular AMPK by dual-small molecule treatment: AICAR and A769662
- Ginseng leaf extract prevents high fat diet-induced hyperglycemia and hyperlipidemia through AMPK activation
- Resveratrol inhibits cell differentiation in 3T3-L1 adipocytes via activation of AMPK
- AMPK Dilates Resistance Arteries via Activation of SERCA and BKCa Channels in Smooth Muscle
- Activation of AMPK by bitter melon triterpenoids involves CaMKKβ
- Pharmacological activation of AMPK ameliorates perivascular adipose/endothelial dysfunction in a manner interdependent on AMPK and SIRT1
- Activation of AMP-activated protein kinase (AMPK) mediates plumbagin-induced apoptosis and growth inhibition in cultured human colon cancer cells
- AdipoRon, the first orally active adiponectin receptor activator, attenuates postischemic myocardial apoptosis through both AMPK-mediated and AMPK-independent …
- Palmitoleic acid (n-7) increases white adipocytes GLUT4 content and glucose uptake in association with AMPK activation
- The role of ATM in response to metformin treatment and activation of AMPK
- Cardiotrophin-1 eliminates hepatic steatosis in obese mice by mechanisms involving AMPK activation
- Antiadipogenic effect of dietary apigenin through activation of AMPK in 3T3-L1 cells
- Adiponectin-activated AMPK stimulates dephosphorylation of AKT through protein phosphatase 2A activation
- Activation of AMP-activated protein kinase (AMPK) inhibits fatty acid synthesis in bovine mammary epithelial cells
- Liraglutide reduces lipogenetic signals in visceral adipose of db/db mice with AMPK activation and Akt suppression
- AMPK activation may suppress hepatic production of C-reactive protein by stimulating nitric oxide synthase
- Novel mechanism of reducing tumourigenesis: upregulation of the DNA repair enzyme OGG1 by rapamycin-mediated AMPK activation and mTOR inhibition
- EGCG inhibits protein synthesis, lipogenesis, and cell cycle progression through activation of AMPK in p53 positive and negative human hepatoma cells
- … perturbed in peroxisome-deficient hepatocytes due to mitochondrial dysfunction, AMP-activated protein kinase (AMPK) activation, and peroxisome proliferator …
- PKC-dependent human monocyte adhesion requires AMPK and Syk activation
- Requirement of AMPK activation for neuronal metabolic-enhancing effects of antidepressant paroxetine
- Two-step activation of FOXO3 by AMPK generates a coherent feed-forward loop determining excitotoxic cell fate
- … inhibition sensitizes non–small cell lung cancer with T790M mutation to irreversible EGFR inhibitors via translational suppression of mcl-1 by AMPK activation
- Activation of AMPK is necessary for killing cancer cells and sparing cardiac cells
- Activation of AMPK improves lipopolysaccharide-induced dysfunction of the blood–brain barrier in mice
- PPARβ activation induces rapid changes of both AMPK subunit expression and AMPK activation in mouse skeletal muscle
- Effects of AMPK activation and combined treatment with AMPK activators and somatostatin on hormone secretion and cell growth in cultured GH-secreting pituitary …
- Cell cycle arrest in Metformin treated breast cancer cells involves activation of AMPK, downregulation of cyclin D1, and requires p27 Kip1 or p21 Cip1
- Resveratrol activates AMPK and suppresses LPS-induced NF-κB-dependent COX-2 activation in RAW 264.7 macrophage cells
- Reactive oxygen species are produced at low glucose and contribute to the activation of AMPK in insulin-secreting cells
- Activation of AMPK by the Putative Dietary Restriction Mimetic Metformin Is Insufficient to Extend Lifespan in Drosophila
- Therapeutic metformin/AMPK activation promotes the angiogenic phenotype in the ERα negative MDA-MB-435 breast cancer model
- Activation of AMPK improves inflammation and insulin resistance in adipose tissue and skeletal muscle from pregnant women
- ATM and LKB1 dependent activation of AMPK sensitizes cancer cells to etoposide-induced apoptosis
- AMPK suppresses vascular inflammation in vivo by inhibiting signal transducer and activator of transcription-1
- Stabilization and activation of p53 downregulates mTOR signaling through AMPK in mantle cell lymphoma
- Low concentration of metformin induces a p53-dependent senescence in hepatoma cells via activation of the AMPK pathway
- Identification of adenine modulating AMPK activation in NIH/3T3 cells by proteomic approach
- Activation of AMPK α-and γ-isoform complexes in the intact ischemic rat heart
- Effects of biotin supplementation in the diet on adipose tissue cGMP concentrations, AMPK activation, lipolysis, and serum-free fatty acid levels
- Sulforaphane induced adipolysis via hormone sensitive lipase activation, regulated by AMPK signaling pathway
- Stilbenoids from Rheum undulatum Protect Hepatocytes Against Oxidative Stress Through AMPK Activation
- Antidiabetic activities of triterpenoids isolated from bitter melon associated with activation of the AMPK pathway
- Nitric oxide-induced autophagy in MC3T3-E1 cells is associated with cytoprotection via AMPK activation
- Phosphorylation of adipose triglyceride lipase Ser404 is not related to 5′-AMPK activation during moderate-intensity exercise in humans
- Caudal fourth ventricular administration of the AMPK activator 5‐aminoimidazole‐4‐carboxamide‐riboside regulates glucose and counterregulatory hormone profiles …
- Activation of AMPK by pterostilbene suppresses lipogenesis and cell-cycle progression in p53 positive and negative human prostate cancer cells
- Reduction of lipid accumulation in white adipose tissues by Cassia tora (Leguminosae) seed extract is associated with AMPK activation
- Fenofibrate Improves Renal Lipotoxicity through Activation of AMPK-PGC-1α in db/db Mice
- 6-Gingerol inhibits osteosarcoma cell proliferation through apoptosis and AMPK activation
- Aging elevates basal adenosine monophosphate-activated protein kinase (AMPK) activity and eliminates hypoxic activation of AMPK in mouse liver
- The proteasome inhibitor bortezomib induces testicular toxicity by upregulation of oxidative stress, AMP-activated protein kinase (AMPK) activation and deregulation of …
- Remodeling glucose and lipid metabolism through AMPK activation: relevance for treating obesity and type 2 diabetes
- AMPK inhibits MTDH expression via GSK 3β and SIRT 1 activation: potential role in triple negative breast cancer cell proliferation
- The lysosomal v-ATPase-Ragulator complex is a common activator for AMPK and mTORC1, acting as a switch between catabolism and anabolism
- AMPK-dependent phosphorylation of GAPDH triggers Sirt1 activation and is necessary for autophagy upon glucose starvation
- Activation of GLUT1 by metabolic and osmotic stress: potential involvement of AMP-activated protein kinase (AMPK)
- The dipeptidyl peptidase-4 inhibitor teneligliptin attenuates hepatic lipogenesis via AMPK activation in non-alcoholic fatty liver disease model mice
- Effects of AMPK activators on the sub-cellular distribution of fatty acid transporters CD36 and FABPpm
- A769662, a novel activator of AMP-activated protein kinase, inhibits non-proteolytic components of the 26S proteasome by an AMPK-independent mechanism
- Activation of AMPK restricts coxsackievirus B3 replication by inhibiting lipid accumulation
- Acute metformin preconditioning confers neuroprotection against focal cerebral ischaemia by pre‐activation of AMPK‐dependent autophagy
- Hypothalamic AMPK activation blocks lipopolysaccharide inhibition of glucose production in mice liver
- Metformin inhibits growth of eutopic stromal cells from adenomyotic endometrium via AMPK activation and subsequent inhibition of AKT phosphorylation: a …
- Activation of AMPK inhibits cervical cancer cell growth through AKT/FOXO3a/FOXM1 signaling cascade
- Astragalus polysaccharides alleviates glucose toxicity and restores glucose homeostasis in diabetic states via activation of AMPK
- A novel AMPK activator reduces glucose uptake and inhibits tumor progression in a mouse xenograft model of colorectal cancer
- AMPK activation with AICAR provokes an acute fall in plasma [K+]
- Stimulation of glucose transport in response to activation of distinct AMPK signaling pathways
- Eicosapentaenoic acid protects against palmitic acid-induced endothelial dysfunction via activation of the AMPK/eNOS pathway
- Omega-3 polyunsaturated fatty acids antagonize macrophage inflammation via activation of AMPK/SIRT1 pathway
- AS160 phosphorylation is associated with activation of α2β2γ1- but not α2β2γ3-AMPK trimeric complex in skeletal muscle during exercise in humans
- Sasa quelpaertensis Nakai extract and its constituent p-coumaric acid inhibit adipogenesis in 3T3-L1 cells through activation of the AMPK pathway
- Age and obesity-associated changes in the expression and activation of components of the AMPK signaling pathway in human right atrial tissue
- AICAR induced AMPK activation potentiates neuronal insulin signaling and glucose uptake
- Small-molecule activators of AMP-activated protein kinase (AMPK), RSVA314 and RSVA405, inhibit adipogenesis
- Activation of the AMPK-FOXO3 pathway reduces fatty acid–induced increase in intracellular reactive oxygen species by upregulating thioredoxin
- LPS inhibits caspase 3-dependent apoptosis in RAW264. 7 macrophages induced by the AMPK activator AICAR
- AMP-activated protein kinase (AMPK) regulates the insulin-induced activation of the nitric oxide synthase in human platelets
- Activation of cannabinoid CB2 receptor–mediated AMPK/CREB pathway reduces cerebral ischemic injury
- Glucose deprivation accelerates VLDL receptor-mediated TG-rich lipoprotein uptake by AMPK activation in skeletal muscle cells
- AZD8055 induces cell death associated with autophagy and activation of AMPK in hepatocellular carcinoma
- AMPK-HDAC5 pathway facilitates nuclear accumulation of HIF-1α and functional activation of HIF-1 by deacetylating Hsp70 in the cytosol
- AICAR, an activator of AMPK, inhibits adipogenesis via the WNT/β-catenin pathway in 3T3-L1 adipocytes
- AICAR induces Nrf2 activation by an AMPK-independent mechanism in hepatocarcinoma cells
- AICAR and metformin, but not exercise, increase muscle glucose transport through AMPK-, ERK-, and PDK1-dependent activation of atypical PKC
- Hypoxia induces expression and activation of AMPK in rat dental pulp cells
- Activation of AMPK by berberine promotes adiponectin multimerization in 3T3-L1 adipocytes
- Activation of AMPK participates hydrogen sulfide-induced cyto-protective effect against dexamethasone in osteoblastic MC3T3-E1 cells
- l-Glutamine enhances enterocyte growth via activation of the mTOR signaling pathway independently of AMPK
- New dammarane-type glucosides as potential activators of AMP-activated protein kinase (AMPK) from Gynostemma pentaphyllum
- AICAR-induced activation of AMPK inhibits TSH/SREBP-2/HMGCR pathway in liver
- NAD blocks high glucose induced mesangial hypertrophy via activation of the sirtuins-AMPK-mTOR pathway
- Central leptin action improves skeletal muscle AKT, AMPK, and PGC1α activation by hypothalamic PI3K-dependent mechanism
- Activation of insulin signaling and energy sensing network by AICAR, an AMPK activator in insulin resistant rat tissues
- IGF-1 receptor signaling pathways and effects of AMPK activation on IGF-1-induced progesterone secretion in hen granulosa cells
- Quercetin inhibits AMPK/TXNIP activation and reduces inflammatory lesions to improve insulin signaling defect in the hypothalamus of high fructose-fed rats
- Flufenamic acid promotes angiogenesis through AMPK activation
- Resveratrol inhibits proliferation and induces apoptosis of nasopharyngeal carcinoma cell line C666-1 through AMPK activation
- Autophagy facilitates lung adenocarcinoma resistance to cisplatin treatment by activation of AMPK/mTOR signaling pathway
- Hispidulin potently inhibits human glioblastoma multiforme cells through activation of AMP-activated protein kinase (AMPK)
- Olanzapine induces glucose intolerance through the activation of AMPK in the mouse hypothalamus
- Glucose-induced repression of PPARα gene expression in pancreatic β-cells involves PP2A activation and AMPK inactivation
- … in LKB1 protein short form by protein kinase Cζ is required for its nucleocytoplasmic transport and consequent AMP-activated protein kinase (AMPK) activation
- Grape seed extract and resveratrol prevent 4‐nitroquinoline 1‐oxide induced oral tumorigenesis in mice by modulating AMPK activation and associated biological …
- AMPK mediates a pro-survival autophagy downstream of PARP-1 activation in response to DNA alkylating agents
- … in dextran sodium sulfate (DSS)-treated Caco-2 cells and experimental colitis in mice through adenosine monophosphate-activated protein kinase (AMPK) activation
- Lipid metabolism disturbances and AMPK activation in prolonged propofol-sedated rabbits under mechanical ventilation
- AMPK activation represses the human gene promoter of the cardiac isoform of acetyl-CoA carboxylase: Role of nuclear respiratory factor-1
- Benzothiazole derivatives augment glucose uptake in skeletal muscle cells and stimulate insulin secretion from pancreatic β-cells via AMPK activation
- Cigarette smoke exposure triggers the autophagic cascade via activation of the AMPK pathway in mice
- Sestrin2 protects dopaminergic cells against rotenone toxicity through AMPK-dependent autophagy activation
- Global metabolite profiling of mice with high-fat diet-induced obesity chronically treated with AMPK activators R118 or metformin reveals tissue-selective …
- Baicalein induces autophagic cell death through AMPK/ULK1 activation and downregulation of m TORC 1 complex components in human cancer cells
- Rhodiola crenulata extract suppresses hepatic gluconeogenesis via activation of the AMPK pathway
- Poliothrysoside and its derivatives as novel insulin sensitizers potentially driving AMPK activation and inhibiting adipogenesis
- Differential attenuation of AMPK activation during acute exercise following exercise training or AICAR treatment
- (–)-Epigallocathechin-3-gallate, an AMPK activator, decreases ovariectomy-induced bone loss by suppression of bone resorption
- Fermented ginseng attenuates hepatic lipid accumulation and hyperglycemia through AMPK activation
- FATP1 mediates fatty acid-induced activation of AMPK in 3T3-L1 adipocytes
- Activators of the energy sensing kinase AMPK inhibit random cell movement and chemotaxis in U937 cells
- Jinlida granule inhibits palmitic acid induced-intracellular lipid accumulation and enhances autophagy in NIT-1 pancreatic β cells through AMPK activation
- Saponins from Rubus parvifolius L. induce apoptosis in human chronic myeloid leukemia cells through AMPK activation and STAT3 inhibition
- Enhanced expression of WD repeat-containing protein 35 via CaMKK/AMPK activation in bupivacaine-treated Neuro2a cells
- Ilexgenin A inhibits endoplasmic reticulum stress and ameliorates endothelial dysfunction via suppression of TXNIP/NLRP3 inflammasome activation in an AMPK …
- AMPK protects proximal tubular cells from stress-induced apoptosis by an ATP-independent mechanism: potential role of Akt activation
- Induction of autophagy in hepatocellular carcinoma cells by SB203580 requires activation of AMPK and DAPK but not p38 MAPK
- Activation of autophagy and AMPK by gamma‐tocotrienol suppresses the adipogenesis in human adipose derived stem cells
- SIRT1 activation by methylene blue, a repurposed drug, leads to AMPK-mediated inhibition of steatosis and steatohepatitis
- Resveratrol induces brown-like adipocyte formation in white fat through activation of AMP-activated protein kinase (AMPK) α1
- CaM kinase kinase β-mediated activation of the growth regulatory kinase AMPK is required for androgen-dependent migration of prostate cancer cells
- Prior serum-and AICAR-induced AMPK activation in primary human myocytes does not lead to subsequent increase in insulin-stimulated glucose uptake
- A1 adenosine receptor signal and AMPK involving caspase-9/-3 activation are responsible for adenosine-induced RCR-1 astrocytoma cell death
- Osteogenesis and angiogenesis induced by porous β-CaSiO3/PDLGA composite scaffold via activation of AMPK/ERK1/2 and PI3K/Akt pathways
- Phosphorylation of the insulin receptor by AMP-activated protein kinase (AMPK) promotes ligand-independent activation of the insulin signalling pathway in …
- Mangiferin decreases plasma free fatty acids through promoting its catabolism in liver by activation of AMPK
- Nutraceutical activators of AMPK/Sirt1 axis inhibit viral production and protect neurons from neurodegenerative events triggered during HSV-1 infection
- … inhibits endoplasmic reticulum stress-associated thioredoxin-interacting protein/NLRP3 inflammasome activation with regulation of AMPK in endothelial cells
- Activation of autophagy via Ca2+-dependent AMPK/mTOR pathway in rat notochordal cells is a cellular adaptation under hyperosmotic stress
- PDGF-induced airway smooth muscle proliferation is associated with Human antigen R activation and could be weakened by AMPK activation
- AMP‐activated protein kinase (AMPK)–induced preconditioning in primary cortical neurons involves activation of MCL‐1
- Defective myofibroblast formation from mesenchymal stem cells in the aging murine heart: rescue by activation of the AMPK pathway
- The In Vivo Antidiabetic Activity of Nigella sativa Is Mediated through Activation of the AMPK Pathway and Increased Muscle Glut4 Content
- eNOS activation mediated by AMPK after stimulation of endothelial cells with histamine or thrombin is dependent on LKB1
- Dietary aloe reduces adipogenesis via the activation of AMPK and suppresses obesity-related inflammation in obese mice
- GYY4137, a novel hydrogen sulfide-releasing molecule, likely protects against high glucose-induced cytotoxicity by activation of the AMPK/mTOR signal pathway in …
- When metabolism rules perfusion: AMPK-mediated endothelial nitric oxide synthase activation
- NQO1-induced activation of AMPK contributes to cancer cell death by oxygen-glucose deprivation
- Synthesis and biological evaluation of arctigenin ester and ether derivatives as activators of AMPK
- Persimmon tannin accounts for hypolipidemic effects of persimmon through activating of AMPK and suppressing NF-κB activation and inflammatory responses in high …
- The ubiquitin-associated domain of AMPK-related kinases regulates conformation and LKB1-mediated phosphorylation and activation
- … glutamate neurotoxicity in the hippocampus by suppression of ER stress-associated TXNIP/NLRP3 inflammasome activation in a manner dependent on AMPK
- Phyllostachys edulis extract induces apoptosis signaling in osteosarcoma cells, associated with AMPK activation
- Activation of autophagic flux against xenoestrogen bisphenol-A-induced hippocampal neurodegeneration via AMP kinase (AMPK)/mammalian target of …
- Pharmacological activation of AMPK suppresses inflammatory response evoked by IL-6 signalling in mouse liver and in human hepatocytes
- Cadmium induces autophagy through ROS-dependent activation of the LKB1–AMPK signaling in skin epidermal cells
- Activation of AMPK and inactivation of Akt result in suppression of mTOR-mediated S6K1 and 4E-BP1 pathways leading to neuronal cell death in in vitro models of …
- … of glucose uptake in muscular cell by soybean charged peptides isolated by electrodialysis with ultrafiltration membranes (EDUF): activation of the AMPK pathway
- Korean Red Ginseng attenuates ethanol-induced steatosis and oxidative stress via AMPK/Sirt1 activation
- Adiponectin promotes pancreatic cancer progression by inhibiting apoptosis via the activation of AMPK/Sirt1/PGC-1α signaling
- Methyl cinnamate inhibits adipocyte differentiation via activation of the CaMKK2–AMPK pathway in 3T3-L1 preadipocytes
- Dehydrozingerone exerts beneficial metabolic effects in high‐fat diet‐induced obese mice via AMPK activation in skeletal muscle
- Activators of AMPK: Not just for type II diabetes
- A pharmacological activator of AMP-activated protein kinase (AMPK) induces astrocyte stellation
- Calebin‐A inhibits adipogenesis and hepatic steatosis in high‐fat diet‐induced obesity via activation of AMPK signaling
- … overweight males ameliorates obesity-related metabolic alterations and cellular adaptations through anti-aging effects, possibly including AMPK and SIRT1 activation
- … -activated receptor β/δ (PPARβ/δ) agonist GW501516 prevents TNF-α-induced NF-κB activation in human HaCaT cells by reducing p65 acetylation through AMPK and …
- RETRACTED ARTICLE: Betulin inhibits lung carcinoma proliferation through activation of AMPK signaling
- Effect of caloric restriction and AMPK activation on hepatic nuclear receptor, biotransformation enzyme, and transporter expression in lean and obese mice
- FGF21 treatment ameliorates alcoholic fatty liver through activation of AMPK-SIRT1 pathway
- Chronic activation of central AMPK attenuates glucose-stimulated insulin secretion and exacerbates hepatic insulin resistance in diabetic rats
- CAPE (caffeic acid phenethyl ester) stimulates glucose uptake through AMPK (AMP-activated protein kinase) activation in skeletal muscle cells
- Resveratrol via activation of AMPK lowers blood pressure in DOCA-salt hypertensive mice
- Polysaccharopeptide enhanced the anti-cancer effect of gamma-tocotrienol through activation of AMPK
- Piperonal prevents high-fat diet-induced hepatic steatosis and insulin resistance in mice via activation of adiponectin/AMPK pathway
- Activation of autophagy by globular adiponectin attenuates ethanol-induced apoptosis in HepG2 cells: involvement of AMPK/FoxO3A axis
- Nobiletin suppresses adipogenesis by regulating the expression of adipogenic transcription factors and the activation of AMP-activated protein kinase (AMPK)
- Improving arteriovenous fistula patency: transdermal delivery of diclofenac reduces cannulation-dependent neointimal hyperplasia via AMPK activation
- (+)-Catechin attenuates NF-κB activation through regulation of Akt, MAPK, and AMPK signaling pathways in LPS-induced BV-2 microglial cells
- Metabolic respiration induces AMPK-and Ire1p-dependent activation of the p38-Type HOG MAPK pathway
- … as a potential anticancer agent against human prostate cancer–a crucial role on AMPK/mTOR signaling pathway and the interplay with Chk2 activation
- Exendin-4 attenuates cardiac hypertrophy via AMPK/mTOR signaling pathway activation
- Stilbene analogs of resveratrol improve insulin resistance through activation of AMPK
- Green tomato extract attenuates high-fat-diet-induced obesity through activation of the AMPK pathway in C57BL/6 mice
- Translocation of myocardial GLUT-4 and increased glucose uptake through activation of AMPK by AICAR
- Activation of AMPK in human fetal membranes alleviates infection-induced expression of pro-inflammatory and pro-labour mediators
- Effects of aging on cardiac and skeletal muscle AMPK activity: basal activity, allosteric activation, and response to in vivo hypoxemia in mice
- AKT and AMPK activation after high-fat and high-glucose in vitro treatment of prostate epithelial cells
- Resistance exercise-induced S6K1 kinase activity is not inhibited in human skeletal muscle despite prior activation of AMPK by high-intensity interval cycling
- Resveratrol induces AMPK-dependent MDR1 inhibition in colorectal cancer HCT116/L-OHP cells by preventing activation of NF-κB signaling and suppressing cAMP …
- … purine nucleotide biosynthesis: implications of inhibiting 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase to ampk activation and antitumor activity
- Activation of AMPK inhibits cholera toxin stimulated chloride secretion in human and murine intestine
- Snf1/AMPK promotes the formation of Kog1/Raptor-bodies to increase the activation threshold of TORC1 in budding yeast
- Tanshinone IIA induces autophagic cell death via activation of AMPK and ERK and inhibition of mTOR and p70 S6K in KBM‐5 leukemia cells
- CTRP5 ameliorates palmitate-induced apoptosis and insulin resistance through activation of AMPK and fatty acid oxidation
- Resveratrol improves oxidative stress and prevents the progression of periodontitis via the activation of the Sirt1/AMPK and the Nrf2/antioxidant defense pathways in a …
- … inhibit UVB-Induced MMP expression and promote type I procollagen production via repression of MAPK/AP-1/NF-κB and activation of AMPK/Nrf2 in HaCaT cells and …
- Rutaecarpine analogues reduce lipid accumulation in adipocytes via inhibiting adipogenesis/lipogenesis with AMPK activation and UPR suppression
- … stimulates fatty acid oxidation in a leptin receptor-independent manner through the JAK2-mediated phosphorylation and activation of AMPK in skeletal muscle
- Probucol suppresses human glioma cell proliferation in vitro via ROS production and LKB1-AMPK activation
- Regulation of ERK1/2 by ouabain and Na-K-ATPase-dependent energy utilization and AMPK activation in parotid acinar cells
- Effects of Icariin on insulin resistance via the activation of AMPK pathway in C2C12 mouse muscle cells
- AICAR-induced activation of AMPK negatively regulates myotube hypertrophy through the HSP72-mediated pathway in C2C12 skeletal muscle cells
- Ginsenoside Rh2 (S) induces differentiation and mineralization of MC3T3-E1 cells through activation of the PKD/AMPK signaling pathways
- The PPARβ/δ activator GW501516 prevents the down-regulation of AMPK caused by a high-fat diet in liver and amplifies the PGC-1α-Lipin 1-PPARα pathway leading …
- 8-Chloroadenosine sensitivity in renal cell carcinoma is associated with AMPK activation and mTOR pathway inhibition
- Bezafibrate enhances proliferation and differentiation of osteoblastic MC3T3-E1 cells via AMPK and eNOS activation
- Adiponectin offers protection against L166P mutant DJ-1-induced neuronal cytotoxicity mediated by APPL1-dependent AMPK activation
- Angiotensin II receptor blocker telmisartan enhances running endurance of skeletal muscle through activation of the PPAR‐δ/AMPK pathway
- Inhibition of de novo purine synthesis in human prostate cells results in ATP depletion, AMPK activation and induces senescence
- Metformin enhances radiation response of ECa109 cells through activation of ATM and AMPK
- Gomisin J inhibits oleic acid-induced hepatic lipogenesis by activation of the AMPK-dependent pathway and inhibition of the hepatokine fetuin-A in HepG2 cells
- Does LKB1 mediate activation of hepatic AMP-protein kinase (AMPK) and sirtuin1 (SIRT1) after Roux-en-Y gastric bypass in obese rats?
- Melanocortin-induced PKA activation inhibits AMPK activity via ERK-1/2 and LKB-1 in hypothalamic GT1-7 cells
- Compound C inhibits hypoxic activation of HIF-1 independent of AMPK
- Adiponectin mediated APPL1‐AMPK signaling induces cell migration, MMP activation, and collagen remodeling in cardiac fibroblasts
- Mulberry 1-deoxynojirimycin pleiotropically inhibits glucose-stimulated vascular smooth muscle cell migration by activation of AMPK/RhoB and down-regulation of …
- The Polyphenol Extract from Sechium edule Shoots Inhibits Lipogenesis and Stimulates Lipolysis via Activation of AMPK Signals in HepG2 Cells
- Constitutive activation of AMPK α1 in vascular endothelium promotes high‐fat diet‐induced fatty liver injury: Role of COX‐2 induction
- High glucose promotes gap junctional communication in cultured neonatal cardiac fibroblasts via AMPK activation
- Ischemia-induced activation of AMPK does not increase glucose uptake in glycogen-replete isolated working rat hearts
- Reduction in neural performance following recovery from anoxic stress is mimicked by AMPK pathway activation
- CNX-012-570, a direct AMPK activator provides strong glycemic and lipid control along with significant reduction in body weight; studies from both diet …
- Polysaccharide from Fuzi likely protects against starvation-induced cytotoxicity in H9c2 cells by increasing autophagy through activation of the AMPK/mTOR pathway
- TLR4 engagement inhibits AMPK activation through a HMGB1 dependent mechanism
- … tumor necrosis factor‑α‑induced expression of inflammatory molecules and activation of nuclear factor‑κB via the activation of AMPK in vascular endothelial …
- Anti-diabetic effects of Korean red pepper via AMPK and PPAR-γ activation in C2C12 myotubes
- Role of AMPK throughout meiotic maturation in the mouse oocyte: evidence for promotion of polar body formation and suppression of premature activation
- Corpus Cavernosal Smooth Muscle Relaxation Effect of a Novel AMPK Activator, Beta‐Lapachone
- Brown Alga Ecklonia cava Polyphenol Extract Ameliorates Hepatic Lipogenesis, Oxidative Stress, and Inflammation by Activation of AMPK and SIRT1 in High-Fat Diet …
- Deoxypodophyllotoxin suppresses tumor vasculature in HUVECs by promoting cytoskeleton remodeling through LKB1-AMPK dependent Rho A activation
- The effects of novel AMPK activator on human vascular endothelial cells
- Reactivation of latently infected HIV-1 viral reservoirs and correction of aberrant alternative splicing in the LMNA gene via AMPK activation: Common mechanism of …
- Insulin downregulates SIRT1 and AMPK activation and is associated with changes in liver fat, but not in inflammation and mitochondrial oxidative capacity, in …
- Activation of the AMP-activated protein kinase (AMPK) by nitrated lipids in endothelial cells
- Lipopolysaccharides reduce adipogenesis in 3T3-L1 adipocytes through activation of NF-κB pathway and downregulation of AMPK expression
- Systems biology network-based discovery of a small molecule activator BL-AD008 targeting AMPK/ZIPK and inducing apoptosis in cervical cancer
- Xanthigen attenuates high-fat diet-induced obesity through down-regulation of PPARγ and activation of the AMPK pathway
- AMPK-activated protein kinase activation by Impatiens balsamina L. is related to apoptosis in HSC-2 human oral cancer cells
- Exogenous activation of LKB1/AMPK signaling induces G1 arrest in cells with endogenous LKB1 expression
- The selected flavonol glycoside derived from Sophorae Flos improves glucose uptake and inhibits adipocyte differentiation via activation AMPK in 3T3-L1 cells
- Transient receptor potential vanilloid 1 activation induces autophagy in thymocytes through ROS-regulated AMPK and Atg4C pathways
- Ramipril protects the endothelium from high glucose–induced dysfunction through CaMKKβ/AMPK and heme oxygenase-1 activation
- Activation of AMPK/TSC 2/PLD by Alcohol Regulates m TORC 1 and m TORC 2 Assembly in C 2 C 12 Myocytes
- Chitooligosaccharide induces mitochondrial biogenesis and increases exercise endurance through the activation of Sirt1 and AMPK in rats
- Activation of AMPK in rat hypothalamus participates in cold‐induced resistance to nutrient‐dependent anorexigenic signals
- Aβ peptide secretion is reduced by Radix Polygalae‑induced autophagy via activation of the AMPK/mTOR pathway
- Activation of AMPK–Sirt1 pathway by telmisartan in white adipose tissue: A possible link to anti-metabolic effects
- GL-V9, a new synthetic flavonoid derivative, ameliorates DSS-induced colitis against oxidative stress by up-regulating Trx-1 expression via activation of AMPK …
- Mechanism of activation of AMPK and upregulation of OGG1 by rapamycin in cancer cells
- IFI16 induction by glucose restriction in human fibroblasts contributes to autophagy through activation of the ATM/AMPK/p53 pathway
- Metabolic activation of the HOG MAP kinase pathway by Snf1/AMPK regulates lipid signaling at the Golgi
- Long-term consumption of Platycodi radix ameliorates obesity and insulin resistance via the activation of AMPK pathways
- Absence of RIP140 reveals a pathway regulating glut4-dependent glucose uptake in oxidative skeletal muscle through UCP1-mediated activation of AMPK
- TMP21 modulates cell growth in papillary thyroid cancer cells by inducing autophagy through activation of the AMPK/mTOR pathway
- … attenuates high glucose‐induced hepatic lipogenesis in human H ep G 2 cells through activation of the liver kinase B 1 and silent information regulator T 1/AMPK …
- … apoptosis in human leukemia cells via reactive oxygen species generation and activation of reactive oxygen species‐inducible protein kinases (p38‐MAPK, AMPK)
- Physiological role for Angptl4/fiaf in exercise-induced muscle AMPK activation
- (+)-Catechin Attenuates NF-κB Activation Through Regulation of Akt, MAPK, and AMPK Signaling Pathways in LPS-Induced BV-2 Microglial Cells.
- Development of potent adenosine monophosphate activated protein kinase (AMPK) activators
- The nuclear protein Artemis promotes AMPK activation by stabilizing the LKB1–AMPK complex
- Artemisinin inhibits neuroblastoma proliferation through activation of AHP-activated protein kinase (AMPK) signaling
- Mild Electrical Stimulation Increases Stress Resistance and Suppresses Fat Accumulation via Activation of LKB1-AMPK Signaling Pathway in C. elegans
- Modulation of de novo purine biosynthesis leads to activation of AMPK and results in improved glucose handling and insulin sensitivity
- Cooperativity between inhibition of cytosolic K+ efflux and AMPK activation during suppression of hypoxia-induced cellular apoptosis
- Activation of AMPK reduces the co-transporter activity of NKCC1
- Yhhu981, a novel compound, stimulates fatty acid oxidation via the activation of AMPK and ameliorates lipid metabolism disorder in ob/ob mice
- Licochalcone suppresses LXRα-induced hepatic lipogenic gene expression through AMPK/Sirt1 pathway activation
- Korean red ginseng attenuates hepatic lipid accumulation via AMPK activation in human hepatoma cells
- Phosphorylation and activation of AMP-activated protein kinase (AMPK) by metformin in the human ovary requires insulin
- Ca2+/Calmodulin-Dependent Kinase Kinase β (CaMKKβ) Contributes to AMPK Activation in the Heart during Hypoxia
- Resveratrol down-regulates a glutamate-induced tissue plasminogen activator via Erk and AMPK/mTOR pathways in rat primary cortical neurons
- N-Hydroxycinnamide Derivatives of Osthole Ameliorate Hyperglycemia through Activation of AMPK and p38 MAPK
- Ion channel regulation by the LKB1-AMPK signalling pathway: the key to carotid body activation by hypoxia and metabolic homeostasis at the whole body level
- Zyflamend, a polyherbal mixture, inhibits lipogenesis and mTORC1 signalling via activation of AMPK
- Physical exercise decreases fasting hyperglycemia in diabetic mice through AMPK activation
- AMPK activators modulate pro-inflammatory responses in human adipocytes
- Erratum: A novel AMPK activator from Chinese herb medicine and ischemia phosphorylate the cardiac transcription factor FOXO3.
- The activation of AMPK in cardiomyocytes at the very early stage of hypoxia relies on an adenine nucleotide-independent mechanism
- Valsartan independent of AT1 receptor inhibits tissue factor, TLR‐2 and ‐4 expression by regulation of Egr‐1 through activation of AMPK in diabetic conditions
- Ablation of Lgr4 enhances energy adaptation in skeletal muscle via activation of Ampk/Sirt1/Pgc1α pathway
- ERK1/2 antagonize AMPK-dependent regulation of FcεRI-mediated mast cell activation and anaphylaxis
- The ubiquitin-associated domain of AMPK-related protein kinases allows LKB1-induced phosphorylation and activation
- … of ouabain signaling. Focus on “Regulation of ERK1/2 by ouabain and Na-K-ATPase-dependent energy utilization and AMPK activation in parotid acinar cells …
- … triterpenoid saponins from Ilex latifolia (Da Ye Dong Qing) ameliorate lipid accumulation by inhibiting SREBP expression via activation of AMPK in a non …
- Compound 13, an α1-selective small molecule activator of AMPK, inhibits Helicobacter pylori-induced oxidative stresses and gastric epithelial cell apoptosis
- Myeloid derived suppressor cell mediated AMPK activation regulates multiple myeloma cell survival
- Estradiol inhibits cytokine-induced expression of VCAM-1 and ICAM-1 in cultured human endothelial cells via AMPK/PPARα activation
- … derivative displays antiproliferative activity against human hormone-refractory metastatic prostate cancers through activation of LKB1-AMPK-mTOR signaling pathway
- Calanquinone A induces anti-glioblastoma activity through glutathione-involved DNA damage and AMPK activation
- Substance P enhances the activation of AMPK and cellular lipid accumulation in 3T3‑L1 cells in response to high levels of glucose
- Mechanism of action of compound-13: an α1-selective small molecule activator of AMPK
- The effect of AMPK activation on Alzheimer’s-like symptoms in APP mice
- Chronic AMPK activation prevents 20-HETE induced endothelial dysfunction
- DPP‐4 Inhibitor Linagliptin Attenuates Aβ‐induced Cytotoxicity through Activation of AMPK in Neuronal Cells
- AMPK activation in health and disease
- Rutin Reduces Body Weight with an Increase of Muscle Mitochondria Biogenesis and Activation of AMPK in Diet‐induced Obese Rats
- The effect of AMPK activation on Wnt and sFRP5 in TNF-α induced adipocyte metabolic dysfunction in 3T3-L1 cell
- Tumor suppressor gene ING3 induces cardiomyocyte hypertrophy via inhibition of AMPK and activation of p38 MAPK signaling
- Antitumor mechanism of metformin via adenosine monophosphate-activated protein kinase (AMPK) activation
- β‐elemene inhibited expression of DNA methyltransferase 1 through activation of ERK 1/2 and AMPK α signalling pathways in human lung cancer cells: the role of …
- Gastrodin ameliorates oleic acid-induced fat accumulation through activation of AMPK pathway in HL-7702 cells
- The effects of NT1014, a novel AMPK activator, compared to metformin, on ovarian cancer cell proliferation, apoptosis, and tumor growth
- Usnic acid inhibits ER stress activation through AMPK signaling pathway in rat cardiomyocytes
- ETC-1002 regulates immune response, leukocyte homing, and adipose tissue inflammation via LKB1-dependent activation of macrophage AMPK
- Estradiol regulates dorsal vagal complex signal transduction pathway transcriptional reactivity to the AMPK activator 5-aminoimidazole-4-carboxamide-riboside …
- Riluzole increases the rate of glucose transport in L6 myotubes and NSC-34 motor neuron-like cells via AMPK pathway activation
- AS160 phosphorylation is associated with activation of 2 2 1-but not 2 2 3-AMPK trimeric complex in skeletal muscle during exercise in humans
- Antidiabetic effects of Nigella sativa are mediated by activation of insulin and AMPK pathways, and by mitochondrial uncoupling
- AMPK over-activation leads to accumulation of α-synuclein oligomers and decrease of neurites
- Proliferating effect of orotic acid through mTORC1 activation mediated by negative regulation of AMPK in SK-Hep1 hepatocellular carcinoma cells
- Impact of AMPKgamma silencing on AMPK activation and intracellular lipids regulation
- Hypoxia sensitizes skeletal muscle to fasting-induced muscle atrophy; role of AMPK activation
- … enhancing virus replication via activation of phosphatase and tensin deleted on chromosome 10 (PTEN) and AMP-activated protein kinase (AMPK), as well as …
- Transient activation of p38 MAP kinase and up-regulation of Pim-1 kinase in cardiac hypertrophy despite no activation of AMPK
- Induction of apoptosis by ethanol extract of Cnidium officinale in human leukemia U937 cells through activation of AMPK
- Hyperglycemia enhances IGF-I responses and alters the AMPK activation profile that protects against metformin-induced growth inhibition in pancreatic cancer cells
- Dietary L‐lysine supplementation reduces de novo lipogenesis via AMPK activation and malonyl‐CoA suppression
- New potent AMPK activators against colorectal cancer stem cells
- Homogenous fluorescent assays for characterizing small-molecule activators of AMP-activated protein kinase (AMPK)
- Ischaemia-reperfusion-induced kidney injury: Experimental studies on the effects of caloric restriction, AMPK activator AICAR and α2-adrenoceptor agonists in the rat
- A novel role for AMPK as a molecular switch regulating the activation of Akt and RAS signaling in acute lymphoblastic leukemia
- Blood glucose lowering effect of Tridax procumbens in type 2 diabetes may be attributed to AMPK activation and suppression of hepatic gluconeogenesis (259.8)
- Feeding long-chain n− 3 polyunsaturated fatty acids during gestation increases intestinal glucose absorption potentially via the acute activation of AMPK
- Efavirenz induces alterations in lipid metabolism through AMPK activation
- Metformin inhibits TGF-b-induced myofibroblast differentiation through AMPK activation
- Adiponectin Repressed Proliferation of Colon Cancer Cells via AMPK Activation
- New avenue to AMPK activation
- AMP-activated protein kinase (AMPK) activation for the treatment of mitochondrial disease
- P179 Celecoxib-mediated activation of an AMPK-CREB-Nrf2 dependent pathway: a novel mechanism for endothelial cytoprotection in chronic systemic inflammation
- (S)-[6]-Gingerol enhances glucose uptake in L6 myotubes by activation of AMPK in response to [Ca2+]i
- Protection of retinal photoreceptors by activation of AMPK with metformin
- Enhancing AMPK activation during ischemia protects the diabetic heart against reperfusion-injury 2
- AdipoRon, the First Orally Active Adiponectin Receptor Activator, Attenuates Post-ischemic Myocardial Apoptosis via AMPK Activation and Oxidative Stress Reduction
- PPARβ/δ Activation prevents hypertriglyceridemia caused by a high fat diet. Involvement of AMPK and PGC-1α-Lipin1-PPARα pathway
- Short‐term AMPK activation improves vascular endothelial function in old mice by a different mechanism than habitual aerobic exercise
- AMPK activation by AICAR induces mitochondrial biogenesis in the inner ear
- Adiponectin deficiency induced cognitive impairment in aging mice through reductions in insulin sensitivity and AMPK activation (S8. 003)
- Activation of AMPK and PPARγby emodin influences glucose uptake in 3 T3-L1 adipocytes
- Abstract P215: Role for Reduced MIF Secretion in Attenuated AMPK Activation and Ischemic Recovery in the Senescent Heart
- Polo-like kinase 1 directs the AMPK-mediated activation of myosin regulatory light chain at the cytokinetic cleavage furrow independently of energy balance
- Effects of the combined treatment with AMPK activator and somatostatin-14 on hormone secretion and cell proliferation in cultured GH-secreting pituitary tumor cells
- IL15 Promotes Myogenic and Brown Adipose Tissue Associated Genes while Decreasing AMPK Activation in C2C12 Skeletal Muscle Cells
- Rottlerin, a PKC-delta Inhibitor, Strongly Suppresses Cell Cycle Progression in Vascular Smooth Muscle Cell Through AMPK Activation.
- Effects of high hydrostatic pressure extract of Korean fresh ginseng on hepatic lipid accumulation and AMPK activation in HepG2 cells
- MicroRNA Let-7f Augments Angiogenic Properties of Endothelial Progenitor Cells through AMPK Activation and MnSOD Induction in Type 1 Diabetes
- Polo-like kinase 1 regulates activation of AMP-activated protein kinase (AMPK) at the mitotic apparatus
- Effect of AMPK activation on acute exercise‐induced monocarboxylate transporter (MCT) 1 and MCT4 mRNA expression in skeletal muscle
- A Mathematical Model of the Regulation of AMPK Activation
- Small Molecule Activators Of AMPK Block The Glycogen Production Required For Transformation Of Myeloid Leukemia Cells
- Recent research progress in small molecule AMPK direct activators
- Evidence That Activation of AMPK by DHT Inhibits Granulosa Cell Proliferation by Reducing ERK Phosphorylation.
- Metformin improves left ventricular function and survival in heart failure through AMPK-eNOS activation
- Activation of AMP-activated protein kinase (AMPK) by the lipid-based Akt inhibitors, phosphatidylinositol ether lipid analogues (PIAs)
- Lysophosphatidylcholine‐induced mitochondrial ROS formation and activation of AMPK promote macrophage chemotaxis and efferocytosis
- The function of AMPK activation on apoptosis induced by CD437 in cancer cell
- The effects of omega-3 polyunsaturated fatty acids on AMPK activation and lipid metabolism in skeletal muscle
- An Activator Of AMP Activated Kinase (AMPK) Restores Nrf2 Protein Levels Decreased By Chronic Cigarette Smoke Exposure
- Abstract PR15: Antitumor effect of metformin in breast cancer is associated with AMPK and FOXO3a activation
- Constitutive activation of AMP-activated protein kinase (AMPK) propel mitochondrial biogenesis
- Effects of AMPK Activation on Insulin Sensitivity and Metabolism
- AMPK Activation Minimizes Organ Injury by Decreasing Endothelial Activation and Inflammation
- Activation of the AMPK regulated metabolic stress response by a small molecule HER2/EGFR tyrosine kinase inhibitor protects cardiac myocytes from apoptotic stimuli
- Pre-conditioning’with Latrepirdine, an AMPK activator, delays ALS progression in SOD1G93A mice
- The effects of NT1014, a novel AMPK activator, on ovarian cancer cell proliferation and apoptosis.
- AMPK activators regulate contractile function of mesenteric arteries
- AMPK Activators Cause Different Vasoconstrictor Responses in Small and Large Muscular Arteries
- A novel AMPK activator, PT‐1, increases gamma1 AMPKassociated activity, but not gamma3 AMPK‐associated activity or glucose transport
- Cellular effects of novel small molecule AMPK activator YLD466D in human prostate cancer
- The effects of heat treatment on AMPK activation in skeletal muscle in type 2 diabetic rats
- Effects of horse age and feeding status on AMPK activation in horses
- Vascular and metabolic actions of insulin and AMPK activation in muscle
- A Redox Dependent Mechanism for Regulation of AMPK Activation by Thioredoxin1 During Energy Starvation
- Estrogen Receptor‐Alpha Activation of AMPK in Vascular Smooth Muscle Cells and Vascular Tone
- Insulin and AMPK activation mimic Fatigue pre-conditioning
- UV and H2O2 induce AMPK activation in cultured skin keratinocytes
- New Cucurbitane triterpenoids from bitter melon with potent antidiabetic properties associated with activation of AMPK
- D-Dopachrome Tautomerase Provides a Novel Cardioprotective Mechanism Through its Modulation on AMPK Activation in Heart During Ischemia-reperfusion
- Scalaran-type sesterterpenes from a Marine Sponge Smenospongia species showing the AMPK activation
- Metabolic and structural remodeling of heart‐derived H9c2 cells by AMPK activation
- BAS/BSCR34 Is an increased AMPK activation during ischaemia essential for the protection of the heart against infarction?
- Effect of modulating adenine nucleotide levels on AMPK activation by targeting AMP-metabolizing enzymes
- Long term AMPK activation limits obesity induced muscle atrophy
- Dynamic transcription factor activities and networks during restores cellular senescence by novel potential AMPK activator from natural compound
- Impacts of AMPK activators and metal stressors on energy levels of Neuro 2a cells
- M12 A769662 Leads to AMPK Activation, Induces Autophagy and has Beneficial Effects IN HD Cells
- Methylene Blue Protects the Liver from Steatohepatitis via AMPK Activation
- AMPK activation is indispensible for the protective effects of caloric restriction in afterload-induced heart failure
- Metformin mediated AMPK activation inhibits translation initiation in breast cancer cells
- Mitochondrial Function and Superoxide Production is Reduced in the Diabetic Kidney and Restored by AMPK Activation
- The Effects of Aging on Skeletal Muscle AMPK Activation and an Analysis of Chronic AICAR Treatment on the Aging Phenotype
- Regulation of p53 mRNA by AMP Kinase (AMPK) activation in C2C12 myoblasts
- AMPK activation and Adenine Nucleotide content in skeletal muscle following different types of high fat feeding
- The effect of metformin-induced AMPK activation on adipogenesis and HIV replication
- Cardioprotection by temperature preconditioning is mediated by free radicals, PKC and AMPK activation
- Sestrin2 Promotes LKB1-Mediated AMPK Activation in the Ischemic Heart
- Antioxidant enzyme-mediated survival of ECM-detached breast cancer cells requires AMPK activation
- Adenosine Monophosphate Activated Kinase (AMPK) and its Key Role in Catabolism: Structure, Regulation, Biological Activity and Pharmacological Activation.
- Abstract A73: AMPK activation mediates dasatinib-induced EGFR degradation and apoptosis in head and neck cancer
- AMP‐Kinase (AMPK) activation attenuates LPS‐induced lung microvascular endothelial injury
- High glucose-induced oxidative stress alters estrogen effects on ER and ER in human endothelial cells: Reversal by AMPK activator
- Sestrin2 Promotes LKB1-Mediated AMPK Activation in the Ischemic Heart
- Sestrin2 is cardioprotective against ischemia/reperfusion injury by promoting LKB1‐mediated AMPK activation
- Inhibition of mTOR Pathway and Induction of Autophagy Block Lymphoma Cell Growth: Role of AMPK Activation
- Supplemental Information Use of Cells Expressing γ Subunit Variants to Identify Diverse Mechanisms of AMPK Activation
- Increased myocardial substrate uptake contributes to the protection of ischemic preconditioning: role of insulin-dependent Akt and AMPK activation
- Effect of hypoxia on AICAR-induced AMPK activation and cytotoxicity in acute lymphoblastic leukemia cells
- 0309: A-769662, a specific AMP-activated protein kinase (AMPK) activator, prevents cardiomyocyte hypertrophy independently of the already identified AMPK …
- AMPK leads to p38 MAPK activation and COX-2 gene expression
- The combined effects of metformin and exercise on AMPK activation, insulin action, and substrate metabolism in insulin resistant individuals
- Injection of AMP‐activated protein kinase (AMPK) activator AICAR acutely reduces blood pressure in Spontaneously Hypertensive Rats
- Co-Activation of AMPK and mTORC1 Is Synthetically Lethal in Acute Myeloid Leukemia
- Differential AMPK Activation and Contractile Function in Rabbit Leg and Neck Arteries in Response to Oxygen and Glucose Deprivation
- The Effects of Chronic AMPK Activation on Hepatic Triglyceride Accumulation and Glycerol-3-Phosphate AcyltransferaseActivity with High Fat Feeding
- The Synthetic Polyphenol and AMPK Activator, S17834, Improves Diet-Induced Obesity, Insulin Resistance, Hyperlipidemia, and Atherosclerosis in LDL Receptor …
- FXR Activation by Chenodeoxycholic Acid Induces Detoxifying Enzymes through AMPK and ERK1/2-mediated Phosphorylation of C/EBPβ
- SIRT3-AMPK Activation by Nitrite and Metformin Improves Hyperglycemia and Normalizes PH-HFpEF
- Phosphorylation-Dependent Nuclear-Cytoplasmic Translocation of LKB1: A Molecular Mechanism for Adiponectin-and Metformin-Stimulated AMPK Activation.
- The MIF Receptor (CD74) Regulates AMPK Activation and Cardiac Injury Following Ischemia
- Sevoflurane preconditioning increases AMPK activation during ischaemia and reperfusion in isolated rat hearts: 4AP4-4
- Chronic AMPK activation induces beneficial phenotypic adaptations in mdx mouse skeletal muscle
- Substance X stimulated Glucose Uptake in HepG2 and Mouse Hepatocyte Cells by AMPK activation.
- Lipid emulsion rescue therapy blocks AMPK activation and Akt inhibition induced by bupivcaine cardiotoxicity (1154.9)
- Regulation of LKB1-STRAD-MO25 complex expression and activation of AMPK in skeletal muscle by thyroid hormone
- Contraction‐induced fatty acid uptake and oxidation are regulated in part via CaMKKβ‐dependent AMPK activation in perfused rat muscle
- AMPK Activator AICAR Inhibits Hepatic Gluconeogenesis and Fatty Acid Oxidation.
- Activation of AMPK: A necessary element in effective targeted tumor therapy
- An Exploratory Analysis of AMPK and ACC Activation in Colorectal Primary Tumors and their Corresponding Metastasis
- Targeting Myeloid Derived Suppressor Cells (MDSC) Using a Novel Adenosine Monophosphate-activated Protein Kinase (AMPK) Activator: OSU-53.
- Effect of pomegranate vinegar on visceral fat reduction via AMPK activation in obese subjects
- AMPK activation by a novel small molecule of mitochondrial regulation enhances fatty acid oxidation, ketogenesis and branched chain amino acid catabolism in vivo
- The acute insulin sensitizing effects of troglitazone are mediated by AMPK activation and inhibition of pyruvate dehyrogenase activity
- AMPK activation vs. inhibition induces apoptosis in acute lymphoblastic leukemia cells by differentially altering PI3K/Akt/mTOR or RAS/cRAF/MEK/Erk signaling
- Abstract 708A: Suppression of glycolysis by retinoic acid sensitizes hepatocellular carcinoma cells to apoptosis induced by sorafenib via AMPK activation
- HMGCoA Reductase Inhibition Reverses Myocardial Fibrosis and Diastolic Dysfunction Through AMPK Activation in a Mouse Model of Metabolic Syndrome
- Abstract LB-171: Dietary agent induced AMPK activation: Targeting stem cells for the prevention of colon cancer
- … contribution of utrophin A versus other components of the slow, oxidative phenotype in the beneficial adaptations of dystrophic muscle fibers following AMPK activation
- Restoration of Angiogenic Balance and Improved Endothelial Cell Function via Ampk Activation is Hypoxia and Ischemia Dependent in Trophoblast Cells and …
- … Novel Mechanism of Preconditioning: Attenuating Reperfusion Injury through Enhanced Myocardial Substrate Uptake via Insulin-Stimulated Akt and AMPK Activation
- The Anti‐Lipolytic Effects of Acute AICAR‐Induced AMPK Activation in Visceral and Subcutaneous Rat Adipose Tissue is Independent of HSL Phosphorylation on …
- Exogenous AMPK Activation Improves Myofibroblast Maturation and Scar Formation in the Infarcted Aging Heart
- Ajoene, a stable garlic byproduct, inhibits high‐fat diet‐induced hepatic steatosis and oxidative injury via LKB1‐mediated AMPK activation
- AICAR Induces Apoptosis in Chronic Lymphocytic Leukemia Cells through the Mitochondrial Pathway and Independently of p53 Pathway and AMPK Activation.
- Chronic AICAR‐induced AMP‐dependent kinase (AMPK) activation exerts an anti‐lipogenic effect in isolated rat adipocytes
- Novel 4-Oxothienopyrimidinyl Propanoic Acid Derivatives as AMPActivated Protein Kinase (AMPK) Activators
- Combined grape polyphenols regulate mammalian target of rapamycin (mTOR) signaling via a dual mechanism of Akt inhibition and AMPK activation
- Adiponectin Increases DAB2, a Tumor Suppressor Gene, in Human Aortic Smooth Muscle Cells via AMPK Activation
- The AMPK activation by sauchinone, a Saururus chinensis lignan, enables hepatocytes to protect against the toxicity induced by iron overload
- Docosahexaenoic acid-induced cell death may be related to inhibition of mTOR through AMPK activation and PI3K/Akt inhibition in human non-small cell lung cancer …
- Enhanced activation of cellular AMPK by dual small
- The effects of NT-1044, a novel AMPK activator, on endometrial cancer cell proliferation and apoptosis
- SDF-1ß Protects Cardiac Cells From Nitrosative Damage/ER Stress-mediated Fibrosis Through CXCR7-dependent AMPK Activation and IL-6 Generation
- Chronic activation of AMPK limits hepatic triglyceride accumulation independent of changes in total glycerol‐3‐phosphate‐acyltransferase activity
- Pemetrexed induces a strong activation of AMPK in human carcinoma cells, even in the absence of LKB1
- Effects of Biotin Supplementation in the Diet on Adipose Tissue cGMP Concentrations, AMPK Activation, Lipolysis, and Serum-Free Fatty Acid Levels
- P47: AMPK activation by nitrite and metformin increases glut-4 mediated glucose uptake and normalizes pulmonary venous hypertension in a rat model of severe …
- AICAR‐induced Activation of AMPK Causes Phosphorylation of p38 MAPK gamma in Resting Skeletal Muscle
- Adipose cells induce phospho-Thr-172 AMPK production by epinephrine or CL316243 in mouse 3T3-L1 adipocytes or MAPK activation and G protein …
- AMPK Phosphorylation Modulates Pain by Activation of NLRP3 Inflammasome
- 1 AMPK activation by glucagon-like peptide-1 prevents NADPH oxidase 2 activation induced by hyperglycemia in adult cardiomyocytes. 3
- Urocortin Stimulates Glucose Uptake in the Hypoxic Heart by Activation of PKCε-AMPK Pathway.
- The effects of NT-1044, a novel AMPK activator, on endometrial cancer cell proliferation, apoptosis and cell stress
- AMPK-induced activation of Akt by AICAR is mediated by IGF-1R dependent and independent mechanisms in acute lymphoblastic leukemia
- Hypoxia Leads to Ca2+/Calmodulin-Dependent Kinase Kinase β (CaMKKβ) Activation/AMPK Phosphorylation, Na,K-ATPase Endocytosis and Impaired Alveolar …
- B27 MITOCHONDRIA AND METABOLIC DYSFUNCTION IN PULMONARY HYPERTENSION: Ampk Activation By Nitrite And Metformin Increases Glut4-Mediated …
- C96 SUGARS AND FATS-ENERGY UTILIZATION IN PULMONARY HYPERTENSION: Sirt3-Ampk Activation By Nitrite And Metformin Improves Hyperglycemia And …
- AICAR Prevents Heat Induced Sudden Death in RyR1 Mutant Mice Independent of AMPK Activation Johanna T. Lanner, Dimitra K. Georgiou, Adan Dagnino …
- … to Rutaecarpine analogues reduce lipid accumulation in adipocytes via inhibiting adipogenesis/lipogenesis with AMPK activation and UPR suppression
- Folic acid supplementation during high fat diet feeding restores AMP-activated protein kinase (AMPK) activation via an AMP-LKB1 dependent mechanism 2
- Evidence for Activation of AMP Kinase (AMPK) in Nephropathic Cystinosis
- Regulation of mTOR pathway by the orphan nuclear receptor NR4A1 (TR3/Nur77) in non-small cell lung cancer: Role of TR3 in AMPK activation
- Scavenger Receptor CD36 Mediates Inhibition of Cholesterol Synthesis via Activation of the LKB1-AMPK Pathway and Insig1/Insig2 Expression in Hepatocytes
- Chronic activation of AMPK enhances insulin‐sensitive fatty acid uptake but not oxidaiton in L6 cells
- 022 MitoQ10 decreases AMPK activation in endothelial cells from patients with coronary artery disease and diabetes
- AMP Kinase (AMPK) activator 5‐aminoimidazole‐4‐carboxamide‐1‐β‐D‐ribofuranoside (AICAR) alters vascular smooth muscle vasomotor responses in thoracic …
- Abstract# 4411: AMP-activated protein kinase (AMPK) activation reduces prostate tumor cell growth via inhibition of fatty acid synthase
- Expression and activation of the 5’AMP-activated protein kinase (AMPK) in exercising and energy-depleted cells: an investigation into the molecular basis …
- Polysaccharopeptide enhanced the anti-cancer effect of gammatocotrienol through activation of AMPK
- Activation of AMP-Activated Protein Kinase (AMPK) by Neuroglucopenia in Hypothalamus Is not Mediated by Ca [sup 2+]/Calmodulin-Dependent Protein Kinase …
- Myeloma Cell Proliferation Is Inhibitied by the Activation of Adenosine Monophosphate Activated Protein Kinase (AMPK).
- 0358: Differential AMP-activated protein kinase (AMPK) activation in platelets, in response to various agonists. Comparison between human and murine platelets
- Anthocyanins of Black Soybean (cv. Cheongja 3) Induce Autophagy via AMPK Activation in U2OS cells
- Attenuation of the Leptin-Induced Hypertrophy by NF-kB Inhibition Requires Activation of AMPK in Neonatal Cardiomyocytes
- Activation Of AMPK Protects Photoreceptors From Light Damage By Preventing Oxidative Stress, And Requires Signaling Through GP130 And STAT3
- Toll-Like Receptor 4-Deficiency Improves Ischemic Cardiomyocytes Contractile Dysfunction via Augmentation of AMPK Activation
- Activation of AMPK inhibits pulmonary arterial remodeling
- The ATM activator chloroquine stimulates phosphorylation of AMP activated protein kinase (AMPK) and acetyl CoA‐carboxylase (ACC) independent of ATM
- Aberrant Activation of γ2-AMPK Increases Cardiac Growth Through Cellular Hypertrophy and Hyperplasia
- AMP-activated protein kinase (AMPK) blocks the effects of PDGF by PI3K-independent signals and is downregulated during in vivo activation of hepatic stellate cells
- Abstract P198: Aberrant Activation of γ2-AMPK Causes Cardiac Hypertrophy Independent of Glycogen Storage
- Activation of AMPK by Pterostilbene Suppresses Lipogenesis and Cell-Cycle Progression in p53 Positive and Negative Human Prostate Cancer Cells
- Activation Of AMPK During Angiotensin II Induced Hypertension Improves Endothelial Function By Inhibition Of NADPH Oxidase And Xanthine Oxidase Activity.
- Validation of the pitavastatin-induced angiomotin-like protein 1 that controls tight junction stability of lung microvascular endothelial cells via LKB1/AMPK activation
- Biotinylated N, N’-diarylureas as probes for the activation of adenosine monophosphate-activated kinase (AMPK)
- Gamma‐tocotrienol antagonizes adipogenesis through activation of AMPK/autophagy axis in primary human adipocytes
- Resveratrol Displays Cardioprotection in Postinfarction Remodeling Through Autophagic Activation Associated With Ampk but not Sirt1 Pathway
- Anti-diabetic effect of Ganoderma lucidum assoiated with the activation of AMPK pathway
- Activation of AMP‐activated protein kinase (AMPK) causes vasorelaxation in isolated mesenteric arteries of hypertensive and normotensive rats
- Agonist-modulated Activation of AMP-activated Protein Kinase: Evidence for a Novel AMPK-Rac1-Akt-eNOS Pathway in Endothelial Cells
- Interleukin-6 Activation of AMPK Involves Both Jak-Stat and Cyclic AMP-Mediated Signaling.
- SDF-1β protects cardiac cells from high fat-induced fibrosis through its receptor cxcr7-mediated AMPK/P38 MAPK activation and IL-6 excretion
- Translational Research in Acute Lung Injury and Pulmonary Fibrosis: GSK3β-dependent inhibition of AMPK potentiates activation of neutrophils and …
- … mitigated cardiac hypoxiareoxygenation injury by Suppressed Autophagy and Reduced Cell Death via inhibition of the activation of AMPK-mTOR signalling pathway …
- Deficiency of LKB1 in heart prevents ischemia-mediated activation of AMPK alpha 2 but not AMPK alpha 1
- … -35; Capsaicin suppresses the migration and invasion of cholangiocarcinoma cells by downregulation of matrix metalloproteinase-9 expression via AMPK activation
- The Pathogenesis of Noise-Induced Hearing Loss is Mediated by the Activation of AMPK via LKB1 and CaMKKβ
- Oxidative Stress Induces GLUT4 Translocation by Dual AMPK Kinase Activation in Cardiac Myocytes
- Chronic Activation of AMP‐Activated Protein Kinase (AMPK)‐alpha1 in Liver Leads to Decreased Adiposity in Mice Fed A Normal or High‐Fat Diet
- An insulin-independent AMPK-dependent survival pathway is activated in glucose-starved cardiac myocytes through IRS-1/PI3-kinase and rictor-mediated activation …
- … Responsiveness In The Metabolic Syndrome After Resistance Training Only May Be Due To Fewer Muscle Slow‐Twitch Fibers And Decreased Activation Of AMPK
- Fresh Frozen Plasma Induces Nitric Oxide Production Through AMPK‐Akt‐mediated eNOS Activation
- ICAM-1-mediated eNOS activation via calcium and AMPK is required for transendothelial lymphocyte migration
- … MATRIX (ECM) REMODELLING INDUCED BY LEPTIN COULD BE ANTAGONISED BY ADIPONECTIN THROUGH THE ACTIVATION OF AMPK VIA ADIPOR1 OF …
- Ramipril protects the endothelium from hyperglycaemia‐induced dysfunction through AMPK and HO‐1 activation (851.10)
- Central administration of histamine H1 receptor agonist, fMPH, blocks olanzapineinduced activation of ampk-cpt1 signaling in the dorsal vagal complex in rats
- Rapid activation by 3, 5, 3′-L-triiodothyronine of AMPK/ACC and Akt/PKB signaling pathways: relation to changes in fuel metabolism and myosin heavy chain …
- INCRETIN AMELIORATES DIABETIC MICROANGIOPATHY IN HEART BY ACTIVATION OF AUTOPHAGY VIA PKA/AMPK AXIS.
- Late-breaking abstract: Influenza A virus infection reduces alveolar fluid clearance by activation of AMPK and subsequent reduction of Na, K-ATPase protein …
- The AMPK-related kinase, Nuak2 is modulated by the activation process and regulates motility of hepatic stellate cells (HSC)
- Cadmium induces autophagy through ROS-dependent activation of the LKB1-AMPK signaling in skin epidermal cells
- Research Article The In Vivo Antidiabetic Activity of Nigella sativa Is Mediated through Activation of the AMPK Pathway and Increased Muscle Glut4 Content
- Methyl Cinnamate Inhibits Adipocyte Differentiation via Activation of the CaMKK2–AMPK Pathway in 3T3-L1 Preadipocytes
- Phosphorylation Of The Insulin Receptor By AMPK Promotes Ligand-independent Activation Of The Insulin-signaling Pathway And Promotes Survival Of Glucose …
- Carolic Restriction Ameliorates Cardiac Steatosis by Activation of Autophagy via Cyclic AMP/AMPK/PKA Axis
- … Dysfunction and Hypertrophy through Impaired PTEN-Induced Activation of PTEN Induced Putative Kinase 1 (Pink1) and AMP-Activated Protein Kinase (AMPK)
- Cationic polystyrene nanosphere induces autophagy through inhibition of the Akt/mTOR and activation of the AMPK signaling pathways in macrophage and epithelial …
- THE AMPK RELATED KINASE NUAK2 INTERACTS WITH TGF-BETA AND REGULATES THE ACTIVATION PROCESS OF HEPATIC STELLATE CELLS (HSC)
- Chronic exposure to palmitate impairs fatty acid oxidation and insulin‐stimulated glucose uptake despite activation of AMPK in skeletal muscle cells
- P-215 Induction of apoptosis by 7, 8-dihydroxyflavone in human colon cancer HCT-116 cells through activation of p53 and AMPK signaling pathways
- Cucurbitacin E induces apoptosis and attenuates activation of hepatic stellate cells via PI3K/Akt-AMPK-mTOR signaling pathway
- Resveratrol-induced activation of the SIRT1/AMPK axis in human CD4 T cells triggers replicative stress and an ATR-dependent cell cycle arrest
- GW26-e1362 Activation of Cannabinoid Receptor 2 improves therapeutic efficacy of Adipose-Derived Mesenchymal Stem Cells to alleviate myocardial ischemia injury …
- Luminal glucose (G)‐induced activation of intestinal phosphate (Pi) uptakes involves glucose‐6‐phosphate (G6Pase) and AMP‐Kinase (AMPK)
- Transient Receptor Potential Vanilloid 1 (TRPV1) activation induces autophagy in thymocytes through ROS-regulated AMPK and Atg4C pathways.
- VCAM-1 promoted by leptin could be offset by adiponectin through the activation of ampk via adipoR1 receptor of VECs in 3D vessel model
- … intestinal epithelial cells (IECs) occurs via phosphatidylinositol 3‐kinase (PI3‐K) mediated activation of adenosine monophosphate‐activated protein kinase (AMPK)
- Activation of AMP-activated protein kinase (AMPK) inhibits chondrocyte catabolic response to pro-inflammatory cytokines and up-regulates anti-oxidant genes via …
- Examination of the domain structure upon binding of allosteric activator 5′-AMP of heterotrimeric AMP-activated protein kinase (AMPK)
- Abstract# 3900: Resveratrol suppresses insulin-like growth factor-1 promoted colon cancer cell growth via activation of p53/AMPK/TSC-2 and suppression of IGF-1R …
- Activation of TASK‐2 by hypoxia: is it via ROS, AMPK or H2S?
- 13: ACTIVATION OF AMPK REDUCES ACUTE RENAL FAILURE AND HEPATIC INJURY IN A RODENT MODEL OF SEPSIS
- 940: PHARMACOLOGICAL ACTIVATION OF AMPK IMPROVES CARDIAC DYSFUNCTION IN EXPERIMENTAL SEPSIS IN MICE.
- … (ATM) prevents the prolonged increase in phosphorylation of Akt substrate of 160 kDa (AS160) subsequent to activation of the AMP‐activated protein kinase (AMPK)
- JKCF1-3 Metformin decreases airway remodeling via activation of AMPK (Inflammatory cells in allergic diseases, Free Paper Session 1, Japan-Korea-China Joint …
- VCAM-1 promoted by leptin could be offset by adiponectin through the activation of AMPK via AdipoR1 receptor of VECS in 3D vessel model
- Abstract LB-25: Activation of AMPK by ATM in reponse to AICAR and metformin
- Loss of AMPK activation promotes the invasion and metastasis of pancreatic cancer through an HSF 1‐dependent pathway
- EGCG reduces obesity and white adipose tissue gain partly through AMPK activation in mice
- An lncRNA switch for AMPK activation
- Lipid accumulation in HepG2 cells is attenuated by strawberry extract through AMPK activation
- Predictive and preventive significance of AMPK activation on hepatocarcinogenesis in patients with liver cirrhosis
- AMPK activation by metformin suppresses abnormal extracellular matrix remodeling in adipose tissue and ameliorates insulin resistance in obesity
- Metformin transiently inhibits colorectal cancer cell proliferation as a result of either AMPK activation or increased ROS production
- Recent progress in the identification of adenosine monophosphate-activated protein kinase (AMPK) activators
- Palmitoleic acid improves metabolic functions in fatty liver by PPARα‐dependent AMPK activation
- AMPK activation enhances the anti-atherogenic effects of high density lipoproteins in apoE−/− mice
- β-Hydroxybutyrate suppresses inflammasome formation by ameliorating endoplasmic reticulum stress via AMPK activation
- AMPK activation prevents and reverses drug-induced mitochondrial and hepatocyte injury by promoting mitochondrial fusion and function
- AMPK activation promotes tight junction assembly in intestinal epithelial Caco-2 cells
- CircACC1 regulates assembly and activation of AMPK complex under metabolic stress
- AMPK activation protects against diet-induced obesity through Ucp1-independent thermogenesis in subcutaneous white adipose tissue
- AMPK activation protects from neuronal dysfunction and vulnerability across nematode, cellular and mouse models of Huntington’s disease
- Calcium-oxidant signaling network regulates AMP-activated protein kinase (AMPK) activation upon matrix deprivation
- AMPK activation regulates LTBP4-dependent TGF-β1 secretion by pro-inflammatory macrophages and controls fibrosis in Duchenne muscular dystrophy
- Chronic AMPK activation via loss of FLCN induces functional beige adipose tissue through PGC-1α/ERRα
- Adenosine monophosphate-activated protein kinase (AMPK) activators for the prevention, treatment and potential reversal of pathological pain
- Chitosan oligosaccharide suppresses synovial inflammation via AMPK activation: An in vitro and in vivo study
- AMPK activation serves a critical role in mitochondria quality control via modulating mitophagy in the heart under chronic hypoxia
- Exercise-induced AMPK activation is involved in delay of skeletal muscle senescence
- Astragalus Polysaccharide Improves Insulin Sensitivity via AMPK Activation in 3T3-L1 Adipocytes
- Towards multi-target antidiabetic agents: Discovery of biphenyl-benzimidazole conjugates as AMPK activators
- Loss of the E3 ubiquitin ligase MKRN1 represses diet-induced metabolic syndrome through AMPK activation
- Berberine enhances the AMPK activation and autophagy and mitigates high glucose-induced apoptosis of mouse podocytes
- AMPK Activation and Metabolic Reprogramming by Tamoxifen through Estrogen Receptor–Independent Mechanisms Suggests New Uses for This Therapeutic …
- Rhizoma coptidis and berberine as a natural drug to combat aging and aging-related diseases via anti-oxidation and AMPK activation
- AMPK activators: mechanisms of action and physiological activities
- Synthetic energy sensor AMPfret deciphers adenylate-dependent AMPK activation mechanism
- Metformin prevents nigrostriatal dopamine degeneration independent of AMPK activation in dopamine neurons
- Long feeding high-fat diet induces hypothalamic oxidative stress and inflammation, and prolonged hypothalamic AMPK activation in rat animal model
- AMPK activation reduces the number of atheromata macrophages in ApoE deficient mice
- AMPK activators suppress breast cancer cell growth by inhibiting DVL3-facilitated Wnt/β-catenin signaling pathway activity
- Mitochondria related peptide MOTS-c suppresses ovariectomy-induced bone loss via AMPK activation
- Effects of isorhamnetin on adipocyte mitochondrial biogenesis and AMPK activation
- Ginkgolic acid inhibits the invasiveness of colon cancer cells through AMPK activation
- Sirt6 suppresses high glucose-induced mitochondrial dysfunction and apoptosis in podocytes through AMPK activation
- 6PGD inhibition sensitizes hepatocellular carcinoma to chemotherapy via AMPK activation and metabolic reprogramming
- Alleviation of paclitaxel-induced mechanical hypersensitivity and hyperalgesic priming with AMPK activators in male and female mice
- … high‐fat‐diet‐induced obesity and anxiety in mice by inducing AMPK activation and SIRT1 expression and inhibiting gut microbiota‐mediated NF‐κB activation
- Protective effects of gomisin N against hepatic steatosis through AMPK activation
- Inhibition of mi RNA‐27b enhances neurogenesis via AMPK activation in a mouse ischemic stroke model
- Thalidezine, a novel AMPK activator, eliminates apoptosis-resistant cancer cells through energy-mediated autophagic cell death
- Metformin inhibits advanced glycation end products-induced inflammatory response in murine macrophages partly through AMPK activation and RAGE/NFκB …
- Linking energy sensing to suppression of JAK-STAT signalling: a potential route for repurposing AMPK activators?
- Activation of AMPK inhibits inflammatory response during hypoxia and reoxygenation through modulating JNK-mediated NF-κB pathway
- Metformin and glucose starvation decrease the migratory ability of hepatocellular carcinoma cells: targeting AMPK activation to control migration
- Anthocyanins abrogate glutamate-induced AMPK activation, oxidative stress, neuroinflammation, and neurodegeneration in postnatal rat brain
- Poria cocus wolf extract ameliorates hepatic steatosis through regulation of lipid metabolism, inhibition of ER stress, and activation of autophagy via AMPK activation
- Berberine improved experimental chronic colitis by regulating interferon-γ- and IL-17A-producing lamina propria CD4+ T cells through AMPK activation
- Itraconazole-induced inhibition on human esophageal cancer cell growth requires AMPK activation
- Capsaicin targets lipogenesis in HepG2 cells through AMPK activation, AKT inhibition and PPARs regulation
- Current evidence for AMPK activation involvement on resveratrol-induced neuroprotection in cerebral ischemia
- Genistein-induced LKB1–AMPK activation inhibits senescence of VSMC through autophagy induction
- SIRT5 deficiency suppresses mitochondrial ATP production and promotes AMPK activation in response to energy stress
- Chitosan oligosaccharide suppresses tumor progression in a mouse model of colitis-associated colorectal cancer through AMPK activation and suppression of NF-κB …
- AICAR, an AMPK activator, protects against cisplatin-induced acute kidney injury through the JAK/STAT/SOCS pathway
- AMPK activation attenuates inflammatory response to reduce ambient PM2. 5-induced metabolic disorders in healthy and diabetic mice
- Natural AMPK activators: an alternative approach for the treatment and management of metabolic syndrome
- … regulation of the AMPK signaling network in response to exercise and insulin in skeletal muscle of male patients with type 2 diabetes: illumination of AMPK activation …
- Possible involvement of normalized Pin1 expression level and AMPK activation in the molecular mechanisms underlying renal protective effects of SGLT2 …
- A systems study reveals concurrent activation of AMPK and mTOR by amino acids
- Phenformin, but not metformin, delays development of T cell acute lymphoblastic leukemia/lymphoma via cell-autonomous AMPK activation
- AMPK phosphorylation modulates pain by activation of NLRP3 inflammasome
- Human sperm motility is downregulated by the AMPK activator A769662
- Chicory (Cichorium intybus L.) polysaccharides attenuate high-fat diet induced non-alcoholic fatty liver disease via AMPK activation
- Green tea polyphenols ameliorate non-alcoholic fatty liver disease through upregulating AMPK activation in high fat fed Zucker fatty rats
- Inhibitory effects of betulinic acid on LPS-induced neuroinflammation involve M2 microglial polarization via CaMKKβ-dependent AMPK activation
- AMPK activation by GSK621 inhibits human melanoma cells in vitro and in vivo
- Involvement of AMPK activation in the inhibition of hepatic gluconeogenesis by Ficus carica leaf extract in diabetic mice and HepG2 cells
- Metformin, an AMPK activator, stimulates the phosphorylation of aquaporin 2 and urea transporter A1 in inner medullary collecting ducts
- ALOX12 inhibition sensitizes breast cancer to chemotherapy via AMPK activation and inhibition of lipid synthesis
- … osteogenic differentiation of senescent bone mesenchymal stem cells through inhibiting endogenous reactive oxygen species production via AMPK activation
- Astragaloside IV attenuates free fatty acid-induced ER stress and lipid accumulation in hepatocytes via AMPK activation
- Hepatic Ago2-mediated RNA silencing controls energy metabolism linked to AMPK activation and obesity-associated pathophysiology
- Melatonin alleviates oxidative stress-inhibited osteogenesis of human bone marrow-derived mesenchymal stem cells through AMPK activation
- AMPK activation by pterostilbene contributes to suppression of hepatic gluconeogenic gene expression and glucose production in H4IIE cells
- Adiponectin upregulates MiR-133a in cardiac hypertrophy through AMPK activation and reduced ERK1/2 phosphorylation
- Thapsigargin sensitizes human esophageal cancer to TRAIL-induced apoptosis via AMPK activation
- Calcitriol reduces hepatic triglyceride accumulation and glucose output through Ca2+/CaMKKβ/AMPK activation under insulin-resistant conditions in type 2 diabetes …
- The suppressive effects of Britannin (Bri) on human liver cancer through inducing apoptosis and autophagy via AMPK activation regulated by ROS
- Novel direct AMPK activator suppresses non-small cell lung cancer through inhibition of lipid metabolism
- Inhibition of adipogenesis by diphlorethohydroxycarmalol (DPHC) through AMPK activation in adipocytes
- Pharmacological AMPK activation induces transcriptional responses congruent to exercise in skeletal and cardiac muscle, adipose tissues and liver
- Policosanol attenuates cholesterol synthesis via AMPK activation in hypercholesterolemic rats
- AMPK activation by metformin inhibits local innate immune responses in the isolated rat heart by suppression of TLR 4-related pathway
- Bitter Orange (Citrus aurantium Linné) Improves Obesity by Regulating Adipogenesis and Thermogenesis through AMPK Activation
- Targeting surface nucleolin induces autophagy-dependent cell death in pancreatic cancer via AMPK activation
- Vitamin D3 regulates steroidogenesis in granulosa cells through AMP‐activated protein kinase (AMPK) activation in a mouse model of polycystic ovary syndrome
- Corosolic acid inhibits adipose tissue inflammation and ameliorates insulin resistance via AMPK activation in high-fat fed mice
- Indole Derivatives Isolated from Brown Alga Sargassum thunbergii Inhibit Adipogenesis through AMPK Activation in 3T3-L1 Preadipocytes
- Hop derived flavonoid xanthohumol inhibits endothelial cell functions via AMPK activation
- The critical role of AMPK in driving Akt activation under stress, tumorigenesis and drug resistance
- AMPK activator AICAR promotes 5-FU-induced apoptosis in gastric cancer cells
- Rescue of mutant rhodopsin traffic by metformin-induced AMPK activation accelerates photoreceptor degeneration
- Serine prevents LPS-induced intestinal inflammation and barrier damage via p53-dependent glutathione synthesis and AMPK activation
- AMPK activation promotes gastroprotection through mutual interaction with the gaseous mediators H2S, NO, and CO
- Bavachin from Psoralea corylifolia Improves Insulin-Dependent Glucose Uptake through Insulin Signaling and AMPK Activation in 3T3-L1 Adipocytes
- Capsaicin exerts synergistic antitumor effect with sorafenib in hepatocellular carcinoma cells through AMPK activation
- Exercise-induced AMPK activation and IL-6 muscle production are disturbed in adiponectin knockout mice
- AMPK activation by AICAR sensitizes prostate cancer cells to radiotherapy
- Nootkatone, an AMPK activator derived from grapefruit, inhibits KRAS downstream pathway and sensitizes non-small-cell lung cancer A549 cells to adriamycin
- AMPK activation is involved in hypoglycemic and hypolipidemic activities of mogroside-rich extract from Siraitia grosvenorii (Swingle) fruits on high-fat diet …
- Mogroside IIIE attenuates LPS‐induced acute lung injury in mice partly through regulation of the TLR4/MAPK/NF‐κB axis via AMPK activation
- … M2 polarization and complement-mediated synapse loss to restore behavioral deficits following hypoxia-ischemic in neonatal mice via AMPK activation
- Eupatilin ameliorates dextran sulphate sodium-induced colitis in mice partly through promoting AMPK activation
- AMPK activation by peri-sciatic nerve administration of ozone attenuates CCI-induced neuropathic pain in rats
- Targeting AMPK: from ancient drugs to new small-molecule activators
- AMP‐activated protein kinase (AMPK) activator A‐769662 increases intracellular calcium and ATP release from astrocytes in an AMPK‐independent manner
- AMPK re-activation suppresses hepatic steatosis but its downregulation does not promote fatty liver development
- Kazinol B from Broussonetia kazinoki improves insulin sensitivity via Akt and AMPK activation in 3T3-L1 adipocytes
- Metformin promotes neuronal differentiation and neurite outgrowth through AMPK activation in human bone marrow–mesenchymal stem cells
- A novel AMPK activator improves hepatic lipid metabolism and leukocyte trafficking in experimental hepatic steatosis
- AMPK activation by A-769662 and 991 does not affect catecholamine-induced lipolysis in human adipocytes
- Mechanisms of paradoxical activation of AMPK by the kinase inhibitors SU6656 and sorafenib
- Chronic activation of γ2 AMPK induces obesity and reduces β cell function
- Liver-specific activation of AMPK prevents steatosis on a high-fructose diet
- Role of Angptl4/Fiaf in exercise-induced skeletal muscle AMPK activation
- An underlying mechanism of dual Wnt inhibition and AMPK activation: mitochondrial uncouplers masquerading as Wnt inhibitors
- Cilostazol exerts antiplatelet and anti‐inflammatory effects through AMPK activation and NF‐kB inhibition on hypercholesterolemic rats
- Mutant IDH1 confers resistance to energy stress in normal biliary cells through PFKP-induced aerobic glycolysis and AMPK activation
- Activation of AMPK-SIRT3 signaling is chondroprotective by preserving mitochondrial DNA integrity and function
- … of three compounds from ShengMai preparations in mice with myocardial ischemia/reperfusion injury through AMPK activation-mediated mitochondrial fission
- Selective activation of AMPK β1-containing isoforms improves kidney function in a rat model of diabetic nephropathy
- Endothelial AMPK activation induces mitochondrial biogenesis and stress adaptation via eNOS-dependent mTORC1 signaling
- Arctigenin inhibits adipogenesis by inducing AMPK activation and reduces weight gain in high‐fat diet‐induced obese mice
- Demethyleneberberine attenuates non-alcoholic fatty liver disease with activation of AMPK and inhibition of oxidative stress
- Methylglyoxal-induced AMPK activation leads to autophagic degradation of thioredoxin 1 and glyoxalase 2 in HT22 nerve cells
- N-myristoyltransferase deficiency impairs activation of kinase AMPK and promotes synovial tissue inflammation
- Aerobic exercise, but not metformin, prevents reduction of muscular performance by AMPk activation in mice on doxorubicin chemotherapy
- Metformin activation of AMPK suppresses AGE-induced inflammatory response in hNSCs
- AMPK activation negatively regulates GDAP1, which influences metabolic processes and circadian gene expression in skeletal muscle
- Hierarchical activation of compartmentalized pools of AMPK depends on severity of nutrient or energy stress
- Resveratrol suppresses glial activation and alleviates trigeminal neuralgia via activation of AMPK
- Dapagliflozin Attenuates Na+/H+ Exchanger-1 in Cardiofibroblasts via AMPK Activation
- IGF-I and IGFBP-2 stimulate AMPK activation and autophagy, which are required for osteoblast differentiation
- Ginseng metabolite Protopanaxadiol induces Sestrin2 expression and AMPK activation through GCN2 and PERK
- AMPK activation by liquiritigenin inhibited oxidative hepatic injury and mitochondrial dysfunction induced by nutrition deprivation as mediated with induction of …
- High expression of PDLIM5 facilitates cell tumorigenesis and migration by maintaining AMPK activation in prostate cancer
- PAN-AMPK activation improves renal function in a rat model of progressive diabetic nephropathy
- Immunomodulatory effect of oleoylethanolamide in dendritic cells via TRPV1/AMPK activation
- High-intensity high-volume swimming induces more robust signaling through PGC-1α and AMPK activation than sprint interval swimming in m. triceps brachii
- AMPK activation of PGC-1α/NRF-1-dependent SELENOT gene transcription promotes PACAP-induced neuroendocrine cell differentiation through tolerance to …
- Linking E-cadherin mechanotransduction to cell metabolism through force-mediated activation of AMPK
- Genistein ameliorates fat accumulation through AMPK activation in fatty acid‐induced BRL Cells
- Targeting myeloid-derived suppressor cells using a novel adenosine monophosphate-activated protein kinase (AMPK) activator
- AMPK activation-dependent autophagy compromises oleanolic acid-induced cytotoxicity in human bladder cancer cells
- Resveratrol and metformin recover prefrontal cortex AMPK activation in diet-induced obese mice but reduce BDNF and synaptophysin protein content
- Postexercise improvement in glucose uptake occurs concomitant with greater γ3-AMPK activation and AS160 phosphorylation in rat skeletal muscle
- AMPK activation ameliorates D-GalN/LPS-induced acute liver failure by upregulating Foxo3A to induce autophagy
- Pharmacological activation of AMPK inhibits incision-evoked mechanical hypersensitivity and the development of hyperalgesic priming in mice
- Suppression of hyperglycemia and hepatic steatosis by black-soybean-leaf extract via enhanced adiponectin-receptor signaling and AMPK activation
- Metformin improves mitochondrial respiratory activity through activation of AMPK
- Inhibiting 6-phosphogluconate dehydrogenase selectively targets breast cancer through AMPK activation
- AMPK activation caused by reduced liver lactate metabolism protects against hepatic steatosis in MCT1 haploinsufficient mice
- … herbal medicine-derived sulforaphene promotes mitophagic cell death in lymphoma cells through CRM1-mediated p62/SQSTM1 accumulation and AMPK activation
- Phenolic acid and flavonoid-rich fraction of Sasa quelpaertensis Nakai leaves prevent alcohol induced fatty liver through AMPK activation
- … inhibits H2O2-induced autophagic death in dopaminergic SH-SY5Y cells via mitigation of ROS-dependent endoplasmic reticulum stress and AMPK activation
- γ-Tocotrienol suppression of the Warburg effect is mediated by AMPK activation in human breast cancer cells
- Carnosic acid as a component of rosemary extract stimulates skeletal muscle cell glucose uptake via AMPK activation
- Activation of AMPK-induced autophagy ameliorates Huntington disease pathology in vitro
- Sustained AMPK activation improves muscle function in a mitochondrial myopathy mouse model by promoting muscle fiber regeneration
- Activation of AMPK inhibits TGF-β1-induced airway smooth muscle cells proliferation and its potential mechanisms
- Barbaloin pretreatment attenuates myocardial ischemia-reperfusion injury via activation of AMPK
- GADD45α alleviates acetaminophen-induced hepatotoxicity by promoting AMPK activation
- Therapeutic effect of dichloroacetate against atherosclerosis via hepatic FGF21 induction mediated by acute AMPK activation
- Metformin-induced AMPK activation stimulates remyelination through induction of neurotrophic factors, downregulation of NogoA and recruitment of Olig2+ precursor …
- Activation of skeletal muscle AMPK promotes glucose disposal and glucose lowering in non-human primates and mice
- Theaflavin 3, 3′‐digallate reverses the downregulation of connexin 43 and autophagy induced by high glucose via AMPK activation in cardiomyocytes
- Fyn phosphorylates AMPK to inhibit AMPK activity and AMP-dependent activation of autophagy
- Antihyperalgesia effect of AMP-activated protein kinase (AMPK) activators in a mouse model of postoperative pain
- AMPK activation by prolonged stimulation with interleukin‐1β contributes to the promotion of GLUT4 translocation in skeletal muscle cells
- AMPK activators contribute to maintain naïve pluripotency in mouse embryonic stem cells
- Effects of AMPK activation on lipolysis in primary rat adipocytes: studies at different glucose concentrations
- YiQiFuMai powder injection attenuates ischemia/reperfusion-induced myocardial apoptosis through AMPK activation
- The AMPK activator A769662 blocks voltage-gated sodium channels: discovery of a novel pharmacophore with potential utility for analgesic development
- Activation of TGF-β-activated kinase 1 (TAK1) restricts Salmonella Typhimurium growth by inducing AMPK activation and autophagy
- Methotrexate-mediated activation of an AMPK-CREB-dependent pathway: a novel mechanism for vascular protection in chronic systemic inflammation
- AICAR-induced AMPK activation inhibits the noncanonical NF-B pathway to attenuate liver injury and fibrosis in BDL rats
- AMPK causes cell cycle arrest in LKB1-deficient cells via activation of CAMKK2
- Kahweol inhibits lipid accumulation and induces Glucose-uptake through activation of AMP-activated protein kinase (AMPK)
- Palbociclib induces activation of AMPK and inhibits hepatocellular carcinoma in a CDK 4/6‐independent manner
- Quercetin oppositely regulates insulin‐mediated glucose disposal in skeletal muscle under normal and inflammatory conditions: The dual roles of AMPK activation
- Simvastatin-induced cell cycle arrest through inhibition of STAT3/SKP2 axis and activation of AMPK to promote p27 and p21 accumulation in hepatocellular …
- AMP-activated kinase (AMPK) activation by AICAR in human white adipocytes derived from pericardial white adipose tissue stem cells induces a partial beige …
- A‑769662, a direct AMPK activator, attenuates lipopolysaccharide‑induced acute heart and lung inflammation in rats
- Noise-induced loss of hair cells and cochlear synaptopathy are mediated by the activation of AMPK
- Non-canonical activation of DAPK2 by AMPK constitutes a new pathway linking metabolic stress to autophagy
- Alamandine acts via MrgD to induce AMPK/NO activation against ANG II hypertrophy in cardiomyocytes
- Erythrocyte adenosine A2B receptor-mediated AMPK activation: a missing component counteracting CKD by promoting oxygen delivery
- Targeted activation of AMPK by GSK621 ameliorates H2O2-induced damages in osteoblasts
- Lutein upregulates the PGC‐1α, NRF1, and TFAM expression by AMPK activation and downregulates ROS to maintain mtDNA integrity and mitochondrial biogenesis …
- Activation of AMPK attenuated cardiac fibrosis by inhibiting CDK2 via p21/p27 and miR-29 family pathways in rats
- Activation of AMPK by metformin improves withdrawal signs precipitated by nicotine withdrawal
- The AMPK-activator AICAR in thyroid cancer: effects on CXCL8 secretion and on CXCL8-induced neoplastic cell migration
- Anti-hypertrophy effect of atorvastatin on myocardium depends on AMPK activation-induced miR-143-3p suppression via Foxo1
- Structural determinants for small-molecule activation of skeletal muscle AMPK α2β2γ1 by the glucose importagog SC4
- Anthraquinones from Morinda longissima and their insulin mimetic activities via AMP-activated protein kinase (AMPK) activation
- γ-6-Phosphogluconolactone, a byproduct of the oxidative pentose phosphate pathway, contributes to AMPK activation through inhibition of PP2A
- AMPK activation by ozone therapy inhibits tissue factor-triggered intestinal ischemia and ameliorates chemotherapeutic enteritis
- 4-Nonylphenol induces autophagy and attenuates mTOR-p70S6K/4EBP1 signaling by modulating AMPK activation in Sertoli cells
- The AMPK activator AICAR ameliorates age-dependent myocardial injury in murine hemorrhagic shock
- HFS‐Triggered AMPK Activation Phosphorylates GSK3β and Induces E‐LTP in Rat Hippocampus In Vivo
- Ginger extract ameliorates obesity and inflammation via regulating microRNA-21/132 expression and AMPK activation in white adipose tissue
- Gain of function AMP‐activated protein kinase γ3 mutation (AMPKγ3R200Q) in pig muscle increases glycogen storage regardless of AMPK activation
- Inhibition of autophagy by captopril attenuates prion peptide-mediated neuronal apoptosis via AMPK activation
- Piperine ameliorated lupus nephritis by targeting AMPK-mediated activation of NLRP3 inflammasome
- Induction of AMPK activation by N,N’-diarylurea FND-4b decreases growth and increases apoptosis in triple negative and estrogen-receptor positive breast …
- Pharmacological activation of AMPK and glucose uptake in cultured human skeletal muscle cells from patients with ME/CFS
- Activation of liver AMPK with PF-06409577 corrects NAFLD and lowers cholesterol in rodent and primate preclinical models
- Globular CTRP9 inhibits oxLDL-induced inflammatory response in RAW 264.7 macrophages via AMPK activation
- Cellular stress and AMPK activation as a common mechanism of action linking the effects of metformin and diverse compounds that alleviate accelerated aging …
- A new AMPK activator, GSK773, corrects fatty acid oxidation and differentiation defect in CPT2-deficient myotubes
- AMPK activation by Tanshinone IIA protects neuronal cells from oxygen-glucose deprivation
- Discovery of a novel chalcone derivative inhibiting CFTR chloride channel via AMPK activation and its anti-diarrheal application
- Activation of AMPK by metformin promotes renal cancer cell proliferation under glucose deprivation through its interaction with PKM2
- Synthesis and In Vitro AMPK Activation of Cycloalkyl/Alkarylbiguanides with Robust In Vivo Antihyperglycemic Action
- Enhancement of glucose utilization by loesenerine through AMPK activation in myotubes
- Activation of AMPK inhibits PDGF-induced pulmonary arterial smooth muscle cells proliferation and its potential mechanisms
- Identification of potential AMPK activator by pharmacophore modeling, molecular docking and QSAR study
- Caffeic acid expands anti-tumor effect of metformin in human metastatic cervical carcinoma HTB-34 cells: implications of AMPK activation and impairment of fatty acids …
- Propofol inhibits HeLa cells by impairing autophagic flux via AMP-activated protein kinase (AMPK) activation and endoplasmic reticulum stress regulated by …
- Vanillic acid attenuates obesity via activation of the AMPK pathway and thermogenic factors in vivo and in vitro
- Ezetimibe, a NPC1L1 inhibitor, attenuates neuronal apoptosis through AMPK dependent autophagy activation after MCAO in rats
- Mevastatin promotes neuronal survival against Aβ-induced neurotoxicity through AMPK activation
- Effect of curcumin (Curcuma longa extract) on LPS-induced acute lung injury is mediated by the activation of AMPK
- AMPK and SIRT1 activation contribute to inhibition of neuroinflammation by thymoquinone in BV2 microglia
- Electroacupuncture attenuates hepatic lipid accumulation via AMP-activated protein kinase (AMPK) activation in obese rats
- SIRT6 regulates metabolic homeostasis in skeletal muscle through activation of AMPK
- Pharmacological and physiological activation of AMPK improves the spliceopathy in DM1 mouse muscles
- AMPK activation restores ischemic post‑conditioning cardioprotection in STZ‑induced type 1 diabetic rats: Role of autophagy
- AMPK/PGC1α activation by melatonin attenuates acute doxorubicin cardiotoxicity via alleviating mitochondrial oxidative damage and apoptosis
- Nucleosides block AICAR-stimulated activation of AMPK in skeletal muscle and cancer cells
- Pterostilbene inhibits nutrient metabolism and induces apoptosis through AMPK activation in multiple myeloma cells
- A novel AMPK activator hernandezine inhibits LPS-induced TNFα production
- The anti-inflammatory function of adenine occurs through AMPK activation and its downstream transcriptional regulation in THP-1 cells
- Preconditioning mice with activators of AMPK ameliorates ischemic acute kidney injury in vivo
- Molybdenum induces pancreatic β-cell dysfunction and apoptosis via interdependent of JNK and AMPK activation-regulated mitochondria-dependent and ER stress …
- Activation of AMPK by simvastatin inhibited breast tumor angiogenesis via impeding HIF‐1α‐induced pro‐angiogenic factor
- Study on the effect of CaMKKβ‐mediated AMPK activation on the glycolysis and the quality of different altitude postmortem bovines longissimus muscle
- PIK3CA mutation sensitizes breast cancer cells to synergistic therapy of PI3K inhibition and AMPK activation
- Metformin protects cells from mutant huntingtin toxicity through activation of AMPK and modulation of mitochondrial dynamics
- Lateral but not medial hypothalamic AMPK activation occurs at the hypoglycemic nadir in insulin-injected male rats: Impact of caudal dorsomedial hindbrain …
- Multiple AMPK activators inhibit l-carnitine uptake in C2C12 skeletal muscle myotubes
- Transient activation of fission yeast AMPK is required for cell proliferation during osmotic stress
- Prior treatment with the AMPK activator AICAR induces subsequently enhanced glucose uptake in isolated skeletal muscles from 24-month-old rats
- Flavonoid derivative exerts an antidiabetic effect via AMPK activation in diet-induced obesity mice
- Activation of cardiac AMPK-FGF21 feed-forward loop in acute myocardial infarction: Role of adrenergic overdrive and lipolysis byproducts
- ROS-mediated activation of AMPK plays a critical role in sulforaphane-induced apoptosis and mitotic arrest in AGS human gastric cancer cells.
- Anti-neuroinflammatory effect of emodin in LPS-stimulated microglia: involvement of AMPK/Nrf2 activation
- Determining AMPK activation via the lysosomal v-ATPase-Ragulator-AXIN/LKB1 axis
- Activation of AMPK α2 inhibits airway smooth muscle cells proliferation
- Cathelicidin-WA attenuates LPS-induced inflammation and redox imbalance through activation of AMPK signaling
- Evolution of the synthesis of AMPK activators for the treatment of diabetic nephropathy: From three preclinical candidates to the investigational new drug PF-06409577
- Casein glycomacropeptide‐derived peptide IPPKKNQDKTE ameliorates high glucose‐induced insulin resistance in HepG2 cells via activation of AMPK signaling
- Inhibition of Adipocyte Differentiation by Anthocyanins Isolated from the Fruit of Vitis coignetiae Pulliat is Associated with the Activation of AMPK Signaling Pathway
- ADIPOQ/adiponectin induces cytotoxic autophagy in breast cancer cells through STK11/LKB1-mediated activation of the AMPK-ULK1 axis
- New insights in the AMPK regulation in chicken spermatozoa: Role of direct AMPK activator and relationship between AMPK and PKA pathways
- Salvinorin A moderates postischemic brain injury by preserving endothelial mitochondrial function via AMPK/Mfn2 activation
- … and activation of α1-and α2-subunit-containing AMP-activated protein kinase (AMPK) heterotrimeric complexes by pharmacological and physiological activators
- … (YW2065): A therapeutic candidate for colorectal cancer via dual activities of Wnt/β-Catenin signaling inhibition and AMP-Activated protein kinase (AMPK) activation
- 5-LO inhibition ameliorates palmitic acid-induced ER stress, oxidative stress and insulin resistance via AMPK activation in murine myotubes
- The pentacyclic triterpenoid, plectranthoic acid, a novel activator of AMPK induces apoptotic death in prostate cancer cells
- Specific Sirt1 activator-mediated improvement in glucose homeostasis requires Sirt1-independent activation of AMPK
- Triptolide induces protective autophagy through activation of the CaMKKβ-AMPK signaling pathway in prostate cancer cells
- Ciclopirox olamine inhibits mTORC1 signaling by activation of AMPK
- … -like peptide-1 prevents methylglyoxal-induced apoptosis of beta cells through improving mitochondrial function and suppressing prolonged AMPK activation
- Activation of AMPK prevents monocrotaline-induced extracellular matrix remodeling of pulmonary artery
- Repurposing existing drugs for new AMPK activators as a strategy to extend lifespan: a computer-aided drug discovery study
- Quercetin-induced AMP-activated protein kinase activation attenuates vasoconstriction through LKB1-AMPK signaling pathway
- AMPK-mediated activation of MCU stimulates mitochondrial Ca2+ entry to promote mitotic progression
- Activation of γ2-AMPK suppresses ribosome biogenesis and protects against myocardial ischemia/reperfusion injury
- AMPK hyper-activation alters fatty acids metabolism and impairs invasiveness of trophoblasts in preeclampsia
- Activation of AMPK attenuates LPS-induced acute lung injury by upregulation of PGC1α and SOD1
- Inhibition by fluoxetine of LH-stimulated cyclic AMP synthesis in tumor Leydig cells partly involves AMPK activation
- Activation of AMPK by berberine induces hepatic lipid accumulation by upregulation of fatty acid translocase CD36 in mice
- AMPK activation of apoptotic markers in human breast cancer cell lines with different p53 backgrounds: MCF-7, MDA-MB-231 and T47D cells
- Acanthoic acid protectsagainst ethanol-induced liver injury: Possible role of AMPK activation and IRAK4 inhibition
- Glycochenodeoxycholate promotes hepatocellular carcinoma invasion and migration by AMPK/mTOR dependent autophagy activation
- Metformin inhibits inflammatory signals in the gut by controlling AMPK and p38 MAP kinase activation
- Metformin-induced activation of AMPK inhibits the proliferation and migration of human aortic smooth muscle cells through upregulation of p53 and IFI16
- Comparative transcriptomic analysis of mice liver treated with different AMPK activators in a mice model of atherosclerosis
- Ampk regulates IgD expression but not energy stress with B cell activation
- Cryptotanshinone from the Salvia miltiorrhiza Bunge Attenuates Ethanol-Induced Liver Injury by Activation of AMPK/SIRT1 and Nrf2 Signaling Pathways
- Combination of deep sea water and Sesamum indicum leaf extract prevents high-fat diet-induced obesity through AMPK activation in visceral adipose tissue
- … -dependent protein kinase (AMPK) activator A-769662 causes arterial relaxation by reducing cytosolic free calcium independently of an increase in AMPK …
- κ-opioid receptor activation protects against myocardial ischemia-reperfusion injury via AMPK/Akt/eNOS signaling activation
- A dual AMPK/Nrf2 activator reduces brain inflammation after stroke by enhancing microglia M2 polarization
- Structural basis of allosteric and synergistic activation of AMPK by furan-2-phosphonic derivative C2 binding
- Activation of AMPK-regulated CRH neurons in the PVH is sufficient and necessary to induce dietary preference for carbohydrate over fat
- Advances on the anti-inflammatory and protective effect of AMPK activators
- Resveratrol via activation of LKB1-AMPK signaling suppresses oxidative stress to prevent endothelial dysfunction in diabetic mice
- … diabetes-induced autophagic flux arrest in ischemic/reperfused heart by ADIPOR (adiponectin receptor) activation involves both AMPK-dependent and AMPK …
- … )phenyl]-1H-indole-3-carboxylic Acid (PF-06409577), a Direct Activator of Adenosine Monophosphate-activated Protein Kinase (AMPK), for the Potential Treatment of …
- AMPK activation, eEF2 inactivation, and reduced protein synthesis in the cerebral cortex of hibernating chipmunks
- AMPK antagonizes hepatic glucagon-stimulated cyclic AMP signalling via phosphorylation-induced activation of cyclic nucleotide phosphodiesterase 4B
- … mitochondrial fragmentation in mesenchymal stromal cells from myelodysplastic syndrome patients through activation of the AMPK/MFF/Drp1 pathway
- Quercetin induces bladder cancer cells apoptosis by activation of AMPK signaling pathway
- Piper retrofractum Vahl. Extract, as a PPARδ and AMPK Activator, Suppresses UVB-Induced Photoaging through Mitochondrial Biogenesis and MMPs …
- Melatonin modulates lipid metabolism in HepG2 cells cultured in high concentrations of oleic acid: AMPK pathway activation may play an important role
- Metformin mediates protection against Legionella pneumonia through activation of AMPK and mitochondrial reactive oxygen species
- BabaoDan attenuates high-fat diet-induced non-alcoholic fatty liver disease via activation of AMPK signaling
- AMP-activated protein kinase (AMPK) activator drugs reduce mechanical allodynia in a mouse model of low back pain
- White to beige conversion in PDE3B KO adipose tissue through activation of AMPK signaling and mitochondrial function
- microRNA-135b expression silences Ppm1e to provoke AMPK activation and inhibit osteoblastoma cell proliferation
- Effects of genetic deletion of soluble 5′-nucleotidases NT5C1A and NT5C2 on AMPK activation and nucleotide levels in contracting mouse skeletal muscles
- Activation of AMPK by medicinal plants and natural products: its role in type 2 diabetes mellitus
- L-Cysteine-Derived H2S Promotes Microglia M2 Polarization via Activation of the AMPK Pathway in Hypoxia-Ischemic Neonatal Mice
- Hypoglycemic Effect of Opuntia ficus-indica var. saboten Is Due to Enhanced Peripheral Glucose Uptake through Activation of AMPK/p38 MAPK Pathway
- … -mediated regulation of microglial polarization in lipopolysaccharide-induced neuroinflammation via activation of the CaMKKβ/AMPK-PGC-1α signaling axis
- Balasubramide derivative 3C modulates microglia activation via CaMKKβ-dependent AMPK/PGC-1α pathway in neuroinflammatory conditions
- Hepatic insulin sensitivity is improved in high‐fat diet‐fed Park2 knockout mice in association with increased hepatic AMPK activation and reduced steatosis
- … acid protects against intestinal fluid secretion and barrier leakage in a mouse model of Vibrio cholerae infection through NF-κB inhibition and AMPK activation
- Activation of AMPK/SIRT1 axis is required for adiponectin-mediated preconditioning on myocardial ischemia-reperfusion (I/R) injury in rats
- AMPK β1 activation suppresses antipsychotic‐induced hyperglycemia in mice
- Baicalein induces caspase‐dependent apoptosis associated with the generation of ROS and the activation of AMPK in human lung carcinoma A549 cells
- Cilostazol protects hepatocytes against alcohol-induced apoptosis via activation of AMPK pathway
- Direct activation of adenosine monophosphate-activated protein kinase (AMPK) by PF-06409577 inhibits flavivirus infection through modification of host cell lipid …
- Donepezil improves neuropathy through activation of AMPK signalling pathway in streptozotocin-induced diabetic mice
- PGC1α activation by pterostilbene ameliorates acute doxorubicin cardiotoxicity by reducing oxidative stress via enhancing AMPK and SIRT1 cascades
- AMPK promotes induction of the tumor suppressor FLCN through activation of TFEB independently of mTOR
- Natural pyrethrins induce autophagy of HepG2 cells through the activation of AMPK/mTOR pathway
- Estrogen negatively regulates the renal epithelial sodium channel (ENaC) by promoting Derlin-1 expression and AMPK activation
- Methyl-β-cyclodextrin restores impaired autophagy flux in Niemann-Pick C1-deficient cells through activation of AMPK
- Departure from optimal O2 level for mouse trophoblast stem cell proliferation and potency leads to most rapid AMPK activation
- Resveratrol attenuates lipopolysaccharide-induced dysfunction of blood-brain barrier in endothelial cells via AMPK activation.
- Stimulating S-adenosyl-l-methionine synthesis extends lifespan via activation of AMPK
- Combined pharmacological activation of AMPK and PPARδ potentiates the effects of exercise in trained mice
- GYY4137 promotes mice feeding behavior via arcuate nucleus sulfur-sulfhydrylation and AMPK activation
- Hydrogen sulfide regulates cardiac mitochondrial biogenesis via the activation of AMPK
- AMPK activation regulates P-body dynamics in mouse sensory neurons in vitro and in vivo
- Activation of AMPK prevents monocrotaline-induced pulmonary arterial hypertension by suppression of NF-κB-mediated autophagy activation
- Metformin inhibits ALK1-mediated angiogenesis via activation of AMPK
- CTAB enhances chemo-sensitivity through activation of AMPK signaling cascades in breast cancer
- Curcumin suppresses colon cancer cell invasion via AMPK-induced inhibition of NF-κB, uPA activator and MMP9
- Hispidulin inhibits hepatocellular carcinoma growth and metastasis through AMPK and ERK signaling mediated activation of PPARγ
- AMPK activation mediated by hinokitiol inhibits adipogenic differentiation of mesenchymal stem cells through autophagy flux
- Ginsenoside Rb2 alleviates hepatic lipid accumulation by restoring autophagy via induction of Sirt1 and activation of AMPK
- Mesenchymal stem cells promote colorectal cancer progression through AMPK/mTOR-mediated NF-κB activation
- Berberine augments ATP-induced inflammasome activation in macrophages by enhancing AMPK signaling
- Rhodiola crenulata extract regulates hepatic glycogen and lipid metabolism via activation of the AMPK pathway
- Crocin ameliorates hepatic steatosis through activation of AMPK signaling in db/db mice
- Betulinic acid inhibits stemness and EMT of pancreatic cancer cells via activation of AMPK signaling
- … receptor γ agonist pioglitazone prevents NF-κB activation in cisplatin nephrotoxicity through the reduction of p65 acetylation via the AMPK-SIRT1/p300 pathway
- Methotrexate improves perivascular adipose tissue/endothelial dysfunction via activation of AMPK/eNOS pathway
- Activation of AMPK is neuroprotective in the oxidative stress by advanced glycosylation end products in human neural stem cells
- Rosmarinic acid mediates mitochondrial biogenesis in insulin resistant skeletal muscle through activation of AMPK
- Cinacalcet-mediated activation of the CaMKKβ-LKB1-AMPK pathway attenuates diabetic nephropathy in db/db mice by modulation of apoptosis and …
- Arhalofenate acid inhibits monosodium urate crystal-induced inflammatory responses through activation of AMP-activated protein kinase (AMPK) signaling
- Activation of AMPK promotes thyroid cancer cell migration through its interaction with PKM2 and β-catenin
- α-hederin induces autophagic cell death in colorectal cancer cells through reactive oxygen species dependent AMPK/mTOR signaling pathway activation
- Sestrin 2 suppresses cells proliferation through AMPK/mTORC1 pathway activation in colorectal cancer
- Methods to study lysosomal AMPK activation
- Identification of a novel 2-oxindole fluorinated derivative as in vivo antitumor agent for prostate cancer acting via AMPK activation
- Activation of AMPK/Nrf2 signalling by Manuka honey protects human dermal fibroblasts against oxidative damage by improving antioxidant response and …
- HL156A, a novel pharmacological agent with potent adenosine-monophosphate-activated protein kinase (AMPK) activator activity ameliorates renal fibrosis in …
- Omega-3 Polyunsaturated Fatty Acids Prevent Toxoplasma gondii Infection by Inducing Autophagy via AMPK Activation
- Exogenous administration of DLK1 ameliorates hepatic steatosis and regulates gluconeogenesis via activation of AMPK
- Punicalagin pretreatment attenuates myocardial ischemia-reperfusion injury via activation of AMPK
- Ursolic acid induces mitochondrial biogenesis through the activation of AMPK and PGC-1 in C2C12 myotubes: a possible mechanism underlying its beneficial effect …
- AICAR antiproliferative properties involve the AMPK-independent activation of the tumor suppressors LATS 1 and 2
- Metformin activation of AMPK-dependent pathways is neuroprotective in human neural stem cells against Amyloid-beta-induced mitochondrial dysfunction
- Inhibition of lipolysis by ilexgenin A via AMPK activation contributes to the prevention of hepatic insulin resistance
- Long non-coding RNA MALAT1 protects human osteoblasts from dexamethasone-induced injury via activation of PPM1E-AMPK signaling
- 13-Ethylberberine reduces HMGB1 release through AMPK activation in LPS-activated RAW264. 7 cells and protects endotoxemic mice from organ damage
- … acid attenuates lipopolysaccharide (LPS)-induced acute lung injury via downregulating inflammatory molecules and upregulating HO-1/AMPK activation
- Alleviation of sepsis‑induced cardiac dysfunction by overexpression of Sestrin2 is associated with inhibition of p‑S6K and activation of the p‑AMPK pathway
- Activation of the AMPK/Sirt1 pathway by a leucine–metformin combination increases insulin sensitivity in skeletal muscle, and stimulates glucose and lipid metabolism …
- Sestrin2, as a negative feedback regulator of mTOR, provides neuroprotection by activation AMPK phosphorylation in neonatal hypoxic-ischemic encephalopathy in …
- Polyphenolics from mango (Mangifera indica L.) suppress breast cancer ductal carcinoma in situ proliferation through activation of AMPK pathway and suppression of …
- M3 muscarinic receptor activation reduces hepatocyte lipid accumulation via CaMKKβ/AMPK pathway
- Irisin alleviates pulmonary epithelial barrier dysfunction in sepsis-induced acute lung injury via activation of AMPK/SIRT1 pathways
- Improvement of lipid and glucose metabolism by capsiate in palmitic acid-treated HepG2 cells via activation of the AMPK/SIRT1 signaling pathway
- Activation of Nrf2 by sulforaphane inhibits high glucose-induced progression of pancreatic cancer via AMPK dependent signaling
- Fibroblast growth factor 19 protects the heart from oxidative stress-induced diabetic cardiomyopathy via activation of AMPK/Nrf2/HO-1 pathway
- Resveratrol activation of AMPK-dependent pathways is neuroprotective in human neural stem cells against amyloid-beta-induced inflammation and oxidative stress
- Methylisoindigo preferentially kills cancer stem cells by interfering cell metabolism via inhibition of LKB1 and activation of AMPK in PDACs
- Pterostilbene decreases cardiac oxidative stress and inflammation via activation of AMPK/Nrf2/HO-1 pathway in fructose-fed diabetic rats
- Berberine protects human retinal pigment epithelial cells from hydrogen peroxide-induced oxidative damage through activation of AMPK
- YAP inhibition by resveratrol via activation of AMPK enhances the sensitivity of pancreatic cancer cells to gemcitabine
- AMPK negatively regulates peripheral myelination via activation of c-Jun
- Nectandrin B-mediated activation of the AMPK pathway prevents cellular senescence in human diploid fibroblasts by reducing intracellular ROS levels
- … of alcoholic liver steatosis by dihydroquercetin through the modulation of AMPK-dependent lipogenesis mediated by P2X7R–NLRP3-inflammasome activation
- Artemisinin Attenuated Hydrogen Peroxide (H2O2)-Induced Oxidative Injury in SH-SY5Y and Hippocampal Neurons via the Activation of AMPK Pathway
- Coenzyme Q10 attenuates high-fat diet-induced non-alcoholic fatty liver disease through activation of the AMPK pathway
- Activation of AMPK in human placental explants impairs mitochondrial function and cellular metabolism
- … stretch induces antioxidant responses and osteogenic differentiation in human mesenchymal stem cells through activation of the AMPK-SIRT1 signaling pathway
- Exacerbated cardiac fibrosis induced by β‐adrenergic activation in old mice due to decreased AMPK activity
- Coumarins ameliorate diabetogenic action of dexamethasone via Akt activation and AMPK signaling in skeletal muscle
- Ethanol extracts of Aster yomena (Kitam.) Honda inhibit adipogenesis through the activation of the AMPK signaling pathway in 3T3-L1 preadipocytes
- Determination of a novel anticancer AMPK activator hernandezine in rat plasma and tissues with a validated UHPLC–MS/MS method: Application to pharmacokinetics …
- Piperine Promotes Glucose Uptake through ROS‐Dependent Activation of the CAMKK/AMPK Signaling Pathway in Skeletal Muscle
- Novel protective mechanism of reducing renal cell damage in diabetes: activation AMPK by AICAR increased NRF2/OGG1 proteins and reduced oxidative DNA …
- Adiponectin limits monocytic microparticle-induced endothelial activation by modulation of the AMPK, Akt and NFκB signaling pathways
- Entada phaseoloides extract suppresses hepatic gluconeogenesis via activation of the AMPK signaling pathway
- AMPK activation induced in pemetrexed‐treated cells is associated with development of drug resistance independently of target enzyme expression
- Activation of autophagy through calcium‐dependent AMPK/mTOR and PKC θ pathway causes activation of rat hepatic stellate cells under hypoxic stress
- Madagascine induces vasodilatation via activation of AMPK
- Dopamine receptor D2 activation suppresses the radiosensitizing effect of aripiprazole via activation of AMPK
- Opposite regulation of CHOP and GRP78 and synergistic apoptosis induction by selenium yeast and fish oil via AMPK activation in lung adenocarcinoma cells
- Facilitation of hippocampal long-term potentiation and reactivation of latent HIV-1 via AMPK activation: common mechanism of action linking learning, memory, and …
- 1, 25-Dihydroxyvitamin D decreases tertiary butyl-hydrogen peroxide-induced oxidative stress and increases AMPK/SIRT1 activation in C2C12 muscle cells
- … migration inhibitory factor promotes cardiac stem cell proliferation and endothelial differentiation through the activation of the PI3K/Akt/mTOR and AMPK …
- The antidepressant effects of ɑ-tocopherol are related to activation of autophagy via the AMPK/mTOR pathway
- Berberine ameliorates high-fat diet-induced non-alcoholic fatty liver disease in rats via activation of SIRT3/AMPK/ACC pathway
- Cucurbitacin E ameliorates hepatic fibrosis in vivo and in vitro through activation of AMPK and blocking mTOR-dependent signaling pathway
- Baicalin and its metabolites suppresses gluconeogenesis through activation of AMPK or AKT in insulin resistant HepG-2 cells
- Activation of Nrf2 by phloretin attenuates palmitic acid-induced endothelial cell oxidative stress via AMPK-dependent signaling
- Irisin alleviates pressure overload-induced cardiac hypertrophy by inducing protective autophagy via mTOR-independent activation of the AMPK-ULK1 pathway
- Sirt1 negatively regulates FcεRI-mediated mast cell activation through AMPK-and PTP1B-dependent processes
- Promotion of Mitochondrial Biogenesis via Activation of AMPK‐PGC1ɑ Signaling Pathway by Ginger (Zingiber officinale Roscoe) Extract, and Its Major Active …
- All-Trans-Retinoic Acid Suppresses Neointimal Hyperplasia and Inhibits Vascular Smooth Muscle Cell Proliferation and Migration via Activation of AMPK …
- Myocardial ischemic postconditioning promotes autophagy against ischemia reperfusion injury via the activation of the nNOS/AMPK/mTOR pathway
- Dexmedetomidine pretreatment inhibits cerebral ischemia/reperfusion‑induced neuroinflammation via activation of AMPK
- Berberine improves motor function recovery by inhibiting endoplasmic reticulum stress-induced neuronal apoptosis via AMPK activation in rats with spinal cord …
- Loss of TP53I11 Enhances the Extracellular Matrix‐independent Survival by Promoting Activation of AMPK
- AMPK-mediated activation of Akt protects renal tubular cells from stress-induced apoptosis in vitro and ameliorates ischemic AKI in vivo
- Delphinidin induced protective autophagy via mTOR pathway suppression and AMPK pathway activation in HER-2 positive breast cancer cells
- The oncometabolite 2-hydroxyglutarate inhibits microglial activation via the AMPK/mTOR/NF-κB pathway
- Berberine-induced activation of AMPK increases hepatic FGF21 expression via NUR77
- PCB126 inhibits the activation of AMPK-CREB signal transduction required for energy sensing in liver
- Activation of AMPK/mTORC1-mediated autophagy by metformin reverses Clk1 deficiency-sensitized dopaminergic neuronal death
- Activation of melanocortin receptor 4 with RO27-3225 attenuates neuroinflammation through AMPK/JNK/p38 MAPK pathway after intracerebral hemorrhage in …
- Chikusetsu saponin IVa attenuates isoprenaline-induced myocardial fibrosis in mice through activation autophagy mediated by AMPK/mTOR/ULK1 signaling
- Polyphenol-enriched extract of Rosa rugosa Thunb regulates lipid metabolism in diabetic rats by activation of AMPK pathway
- Bacterial outer membrane vesicles trigger pre-activation of a xenophagic response via AMPK
- AMPK-mediated cardioprotection of atorvastatin relates to the reduction of apoptosis and activation of autophagy in infarcted rat hearts
- Hypoglycemic effects of esculeoside A are mediated via activation of AMPK and upregulation of IRS-1
- Rosmarinic acid alleviates the endothelial dysfunction induced by hydrogen peroxide in rat aortic rings via activation of AMPK
- 6′-O-acetyl mangiferin from Iris rossii Baker inhibits lipid accumulation partly via AMPK activation in adipogenesis
- Activation of AMPK-dependent SIRT-1 by astragalus polysaccharide protects against ochratoxin A-induced immune stress in vitro and in vivo
- CHIP−/−-Mouse Liver: Adiponectin-AMPK-FOXO-Activation Overrides CYP2E1-Elicited JNK1-Activation, Delaying Onset of NASH: Therapeutic Implications
- Transposable elements, placental development, and oocyte activation: Cellular stress and AMPK links jumping genes with the creation of human life
- Vitexin alleviates ox-LDL-mediated endothelial injury by inducing autophagy via AMPK signaling activation.
- Protective effects of wedelolactone on dextran sodium sulfate induced murine colitis partly through inhibiting the NLRP3 inflammasome activation via AMPK signaling
- Sestrin2 regulates monocyte activation through AMPK‐mTOR nexus under high‐glucose and dyslipidemic conditions
- Raspberry alleviates obesity-induced inflammation and insulin resistance in skeletal muscle through activation of AMP-activated protein kinase (AMPK) α1
- Diallyl trisulfide exerts cardioprotection against myocardial ischemia-reperfusion injury in diabetic state, role of AMPK-mediated AKT/GSK-3β/HIF-1α activation
- Co-activation of AMPK and mTORC1 as a new therapeutic option for acute myeloid leukemia
- WSF-P-1, a novel AMPK activator, promotes adiponectin multimerization in 3T3-L1 adipocytes
- Globular adiponectin inhibits lipopolysaccharide-primed inflammasomes activation in macrophages via autophagy induction: the critical role of AMPK signaling
- Isogambogenic acid inhibits the growth of glioma through activation of the AMPK-mTOR pathway
- Spatholobus suberectus Exhibits Antidiabetic Activity In Vitro and In Vivo through Activation of AKT-AMPK Pathway
- Adiponectin attenuates neuronal apoptosis induced by hypoxia-ischemia via the activation of AdipoR1/APPL1/LKB1/AMPK pathway in neonatal rats
- Feedback activation of AMPK-mediated autophagy acceleration is a key resistance mechanism against SCD1 inhibitor-induced cell growth inhibition
- Activation of AMP-activated protein kinase (AMPK) aggravated postoperative cognitive dysfunction and pathogenesis in aged rats
- Berberine ameliorates high glucose-induced cardiomyocyte injury via AMPK signaling activation to stimulate mitochondrial biogenesis and restore autophagic …
- Casticin suppresses the carcinogenesis of small cell lung cancer H446 cells through activation of AMPK/FoxO3a signaling
- Rhus verniciflua and Eucommia ulmoides Protects Against High-Fat Diet-Induced Hepatic Steatosis by Enhancing Anti-Oxidation and AMPK Activation
- Activation of AMPK by Buddleja officinalis Maxim. Flower Extract Contributes to Protecting Hepatocytes from Oxidative Stress
- Consequences of AMPK activation
- Elimination of cancer stem cells and reactivation of latent HIV-1 via AMPK activation: Common mechanism of action linking inhibition of tumorigenesis and the …
- The Std1 activator of the Snf1/AMPK kinase controls glucose response in yeast by a regulated protein aggregation
- Are SIRT1 activators another indirect method to increase AMPK for beneficial effects on aging and the metabolic syndrome?
- Loss of BRUCE reduces cellular energy level and induces autophagy by driving activation of the AMPK-ULK1 autophagic initiating axis
- Inhibition of JNK and activation of the AMPK-Nrf2 axis by corosolic acid suppress osteolysis and oxidative stress
- Anti-obesity effects of Spirulina maxima in high fat diet induced obese rats via the activation of AMPK pathway and SIRT1
- Resveratrol Prevents ROS-Induced Apoptosis in High Glucose-Treated Retinal Capillary Endothelial Cells via the Activation of AMPK/Sirt1/PGC-1α Pathway
- Monounsaturated fatty acids impede inflammation partially through activation of AMPK
- miR-1273g silences MAGEA3/6 to inhibit human colorectal cancer cell growth via activation of AMPK signaling
- DMC (2′, 4′-dihydroxy-6′-methoxy-3′, 5′-dimethylchalcone) improves glucose tolerance as a potent AMPK activator
- Perioperative oral supplementation with fish oil promotes liver regeneration following partial hepatectomy in mice via AMPK activation
- Antihypertensive peptide purified from Styela clava flesh tissue stimulates glucose uptake through AMP-activated protein kinase (AMPK) activation in skeletal muscle …
- Isoorientin ameliorates APAP-induced hepatotoxicity via activation Nrf2 antioxidative pathway: The involvement of AMPK/Akt/GSK3β
- Bound phenolics from fresh lotus seeds exert anti-obesity effects in 3T3-L1 adipocytes and high-fat diet-fed mice by activation of AMPK
- SIRT1 activation promotes β-cell regeneration by activating endocrine progenitor cells via AMPK signaling-mediated fatty acid oxidation
- Berberine improves cognitive deficiency and muscular dysfunction via activation of the AMPK/SIRT1/PGC-1a pathway in skeletal muscle from naturally aging rats
- Polydatin attenuates potassium oxonate-induced hyperuricemia and kidney inflammation by inhibiting NF-κB/NLRP3 inflammasome activation via the AMPK/SIRT1 …
- Organoseleno cytostatic derivatives: Autophagic cell death with AMPK and JNK activation
- AICAR-dependent activation of AMPK kinase is not accompanied by G1/S block in mouse embryonic stem cells
- Activation of CaMKKβ-AMPK-mTOR pathway is required for autophagy induction by β, β-dimethylacrylshikonin against lung adenocarcinoma cells
- Celecoxib exerts protective effects in the vascular endothelium via COX-2-independent activation of AMPK-CREB-Nrf2 signalling
- Raspberry promotes brown and beige adipocyte development in mice fed high-fat diet through activation of AMP-activated protein kinase (AMPK) α1
- Rapamycin inhibits activation of AMPK-mTOR signaling pathway-induced Alzheimer’s disease lesion in hippocampus of rats with type 2 diabetes mellitus
- The natural flavone acacetin confers cardiomyocyte protection against hypoxia/reoxygenation injury via AMPK-mediated activation of Nrf2 signaling pathway
- Deficiency in the anti‐aging gene Klotho promotes aortic valve fibrosis through AMPK α‐mediated activation of RUNX 2
- … enhances the anti-cancerous effect of imatinib on human acute monocytic leukemia via the induction of autophagy-related apoptosis through AMPK activation
- Antidiabetic effect of tibetan medicine Tang-Kang-Fu-San in db/db mice via activation of PI3K/Akt and AMPK pathways
- Transient activation of AMPK preceding left ventricular pressure overload reduces adverse remodeling and preserves left ventricular function
- … exercise preconditioning promotes autophagy against exhaustive exercise-induced myocardial injury through the activation of the AMPK-mTOR-ULK1 pathway
- Inositol-requiring enzyme 1-dependent activation of AMPK promotes Brucella abortus intracellular growth
- Artemether Activation of AMPK/GSK3β(ser9)/Nrf2 Signaling Confers Neuroprotection towards β-Amyloid-Induced Neurotoxicity in 3xTg Alzheimer’s Mouse …
- … in mediating mitochondrial stress, energy imbalance, and sequential activation of autophagy and apoptosis in mouse Sertoli TM4 cells: possible role of AMPK/ULK1 …
- Upregulation of microRNA-335-5p reduces inflammatory responses by inhibiting FASN through the activation of AMPK/ULK1 signaling pathway in a septic mouse …
- Metabolic reprogramming by the excessive AMPK activation exacerbates antigen-specific memory CD8+ t cell differentiation after acute lymphocytic …
- … inflammation-induced apoptosis in human umbilical vein endothelial cells via suppression of Ca2+-XO-ROS-Drp1-mitochondrial fission axis by activation of AMPK …
- Identification of AMPK activator from twelve pure compounds isolated from Aralia Taibaiensis: implication in antihyperglycemic and hypolipidemic activities
- Identification of direct activator of adenosine monophosphate-activated protein kinase (AMPK) by structure-based virtual screening and molecular docking approach
- Blockade of MerTK activation by AMPK inhibits RPE cell phagocytosis
- Rosiglitazone metformin adduct inhibits hepatocellular carcinoma proliferation via activation of AMPK/p21 pathway
- New synthetic AICAR derivatives with enhanced AMPK and ACC activation
- … esters exert potential antidiabetic effects on glucose and lipid metabolism in cultured murine insulin-sensitive cells through mechanisms implicating activation of AMPK
- The orphan nuclear receptor NR4A1 promotes FcεRI‐stimulated mast cell activation and anaphylaxis by counteracting the inhibitory LKB1/AMPK axis
- Sipjeondaebo-tang Alleviates Oxidative Stress-Mediated Liver Injury through Activation of the CaMKK2-AMPK Signaling Pathway
- Fucosterol inhibits adipogenesis through the activation of AMPK and Wnt/β-catenin signaling pathways
- Terpenoids: An activator of “fuel-sensing enzyme AMPK” with special emphasis on antidiabetic activity
- Acute activation of endothelial AMPK surprisingly inhibits endothelium‐dependent hyperpolarization‐like relaxations in rat mesenteric arteries
- The role of miR-451 in the switching between proliferation and migration in malignant glioma cells: AMPK signaling, mTOR modulation and Rac1 activation …
- Eliciting α7‐nAChR exerts cardioprotective effects on ischemic cardiomyopathy via activation of AMPK signalling
- 2-[2-(4-(trifluoromethyl) phenylamino) thiazol-4-yl] acetic acid (Activator-3) is a potent activator of AMPK
- Mitochondrial dysfunction and apoptosis are attenuated on κ-opioid receptor activation through AMPK/GSK-3β pathway after myocardial ischemia and reperfusion
- Phytol stimulates the browning of white adipocytes through the activation of AMP-activated protein kinase (AMPK) α in mice fed high-fat diet
- GPR40 receptor activation promotes tight junction assembly in airway epithelial cells via AMPK-dependent mechanisms
- Metformin attenuates streptozotocin-induced diabetic nephropathy in rats through activation of AMPK signaling pathway
- Activation of AMPK by OSU53 protects spinal cord neurons from oxidative stress
- Erratum: A novel AMPK activator from Chinese herb medicine and ischemia phosphorylate the cardiac transcription factor FOXO3.
- Ulmus macrocarpa Hance modulates lipid metabolism in hyperlipidemia via activation of AMPK pathway
- Reduction of aging-induced oxidative stress and activation of autophagy by bilberry anthocyanin supplementation via the AMPK–mTOR signaling pathway in aged …
- Impaired myocardial MIF/AMPK activation aggravates myocardial ischemia reperfusion injury in high-fat diet-induced obesity
- Shengmai Injection Suppresses Angiotensin II-Induced Cardiomyocyte Hypertrophy and Apoptosis via Activation of the AMPK Signaling Pathway Through …
- Effect of A-769662, a direct AMPK activator, on Tlr-4 expression and activity in mice heart tissue
- 4‐O‐methylhonokiol protects against diabetic cardiomyopathy in type 2 diabetic mice by activation of AMPK‐mediated cardiac lipid metabolism improvement
- 4-O-methylhonokiol ameliorates type 2 diabetes-induced nephropathy in mice likely by activation of AMPK-mediated fatty acid oxidation and Nrf2-mediated anti …
- Leptin Effect on Acetylation and Phosphorylation of Pgc1α in Muscle Cells Associated With Ampk and Akt Activation in High‐Glucose Medium
- Bempedoic acid. ATP-citrate lyase inhibitor, AMPK activator, Treatment of hypercholesterolemia
- Natural activators of adenosine 5′-monophosphate (AMP)-activated protein kinase (AMPK) and their pharmacological activities
- SIRT3-AMPK activation by nitrite and metformin improves hyperglycemia and normalizes pulmonary hypertension associated with heart failure with preserved …
- Suppression of myopathic lamin mutations by muscle-specific activation of AMPK and modulation of downstream signaling
- Chitooligosaccharide inhibits cyst formation and enlargement through calcium restoration and AMPK activation
- Activation of AMPK for a break in hepatic lipid accumulation and circulating cholesterol
- A novel peptide suppresses adipogenic differentiation through activation of the AMPK pathway
- Glucagon attenuates lipid accumulation in cow hepatocytes through AMPK signaling pathway activation
- Annexin A1 drives macrophage skewing towards a resolving phenotype to accelerate the regeneration of muscle injury through AMPK activation
- Excessive nNOS/NO/AMPK signaling activation mediated by the blockage of the CBS/H2S system contributes to oxygen‑glucose deprivation‑induced …
- (−)-Hydroxycitric acid suppresses lipid droplet accumulation and accelerates energy metabolism via activation of the adiponectin-AMPK signaling pathway in broiler …
- Berberine alleviates oxidized low‐density lipoprotein‐induced macrophage activation by downregulating galectin‐3 via the NF‐κB and AMPK signaling pathways
- Spinosad induces autophagy of Spodoptera frugiperda Sf9 cells and the activation of AMPK/mTOR signaling pathway
- … of Velvet Antler (Cervus elaphus) against Lipopolysaccharide-Induced Acute Lung Injury in Mice by Inhibiting MAPK/NF-κB Activation and Inducing AMPK …
- Region-specific activation of the AMPK system by cocaine: The role of D1 and D2 receptors
- Concurrent regulation of LKB1 and CaMKK2 in the activation of AMPK in castrate-resistant prostate cancer by a well-defined polyherbal mixture with …
- Activation of AMPK/MnSOD signaling mediates anti-apoptotic effect of hepatitis B virus in hepatoma cells
- Tanshinone IIA suppresses FcεRI-mediated mast cell signaling and anaphylaxis by activation of the Sirt1/LKB1/AMPK pathway
- microRNA-300/NAMPT regulates inflammatory responses through activation of AMPK/mTOR signaling pathway in neonatal sepsis
- Activation of AMPK stimulates neurotensin secretion in neuroendocrine cells
- … -protective effect of nectandrin B, a nutmeg lignan, against oxidative stress: Role of Nrf2 activation through ERK phosphorylation and AMPK-dependent inhibition of …
- Zinc finger protein ZPR9 functions as an activator of AMPK-related serine/threonine kinase MPK38/MELK involved in ASK1/TGF-β/p53 signaling pathways
- Alcohol consumption promotes colorectal carcinoma metastasis via a CCL5-induced and AMPK-pathway-mediated activation of autophagy
- Halofuginone ameliorates inflammation in severe acute hepatitis B virus (HBV)-infected SD rats through AMPK activation
- Metformin protects PC12 cells and hippocampal neurons from H2O 2‐induced oxidative damage through activation of AMPK pathway
- Metabolic stress-induced activation of AMPK and inhibition of constitutive phosphoproteins controlling smooth muscle contraction: evidence for smooth …
- Induction of autophagy following TTFields application serves as a survival mechanism mediated by AMPK activation
- LKB1 promotes radioresistance in esophageal cancer cells exposed to radiation, by suppression of apoptosis and activation of autophagy via the AMPK …
- The influence of AICAR-direct activator of AMP-activated protein kinase (AMPK)-on liver proteome in apoE-knockout mice
- Methyleugenol protects against t-BHP-triggered oxidative injury by induction of Nrf2 dependent on AMPK/GSK3β and ERK activation
- Fake inhibitors: AMPK activation trumps inhibition
- Selenadiazole derivatives antagonize hyperglycemia-induced drug resistance in breast cancer cells by activation of AMPK pathways
- Involvement of mTOR and regulation by AMPK in early iodine deficiency-induced thyroid microvascular activation
- Hovenia Dulcis Extract Reduces Lipid Accumulation in Oleic Acid‐Induced Steatosis of Hep G2 Cells via Activation of AMPK and PPARα/CPT‐1 Pathway and in …
- Effect of resistance exercise under conditions of reduced blood insulin on AMPKα Ser485/491 inhibitory phosphorylation and AMPK pathway activation
- Trypsin-treated β-lactoglobulin improves glucose tolerance in C57BL/6 Mice by enhancing AMPK activation and glucose uptake in hepatocytes
- AMPK activator acadesine fails to alleviate isoniazid‐caused mitochondrial instability in HepG2 cells
- Quercetin confers protection of murine sepsis by inducing macrophage M2 polarization via the TRPM2 dependent calcium influx and AMPK/ATF3 activation
- AMPK Activation of Flavonoids from Psidium guajava Leaves in L6 Rat Myoblast Cells and L02 Human Hepatic Cells
- Intact cell assays to monitor AMPK and determine the contribution of the AMP-binding or ADaM sites to activation
- In vitro progesterone production by luteinized human mural granulosa cells is modulated by activation of AMPK and cause of infertility
- DNA-PKcs-mediated phosphorylation of AMPKγ1 regulates lysosomal AMPK activation by LKB1
- Sheng-jiang powder ameliorates obesity-induced pancreatic inflammatory injury via stimulating activation of the AMPK signalling pathway in rats
- … cordycepin derivative IMM-H007 improves endothelial dysfunction by suppressing vascular inflammation and promoting AMPK-dependent eNOS activation in high-fat …
- Ethanol extract of Kalopanax septemlobus leaf induces caspase-dependent apoptosis associated with activation of AMPK in human hepatocellular carcinoma …
- Procyanidin promotes translocation of glucose transporter 4 in muscle of mice through activation of insulin and AMPK signaling pathways
- 3-Chloro-4, 5-dihydroxybenzaldehyde inhibits adipogenesis in 3T3-L1 adipocytes by regulating expression of adipogenic transcription factors and AMPK activation
- The tiliroside derivative, 3-O-[(E)-(2-oxo-4-(p-tolyl) but–3–en–1–yl] kaempferol produced inhibition of neuroinflammation and activation of AMPK and Nrf2/HO-1 …
- FTY720 inhibits the activation of pancreatic stellate cells by promoting apoptosis and suppressing autophagy via the AMPK/mTOR pathway
- Epe1 contributes to activation of AMPK by promoting phosphorylation of AMPK alpha subunit, Ssp2
- Compound C enhances tau phosphorylation at Serine396 via PI3K activation in an AMPK and rapamycin independent way in differentiated SH-SY5Y cells
- Galactomannan pentasaccharide produced from copra meal enhances tight junction integration of epithelial tissue through activation of AMPK
- QSP modeling of liver AMPK activation using NAFLDsym is predicted to reduce steatosis in NAFLD patients
- Anti-inflammatory activities of fenoterol through β-arrestin-2 and inhibition of AMPK and NF-κB activation in AICAR-induced THP-1 cells
- Activation of AMPK alleviates cardiopulmonary bypass‐induced cardiac injury via ameliorating acute cardiac glucose metabolic disorder
- Biophysical Interactions of Direct AMPK Activators
- An antioxidant role by minocycline via enhancing the activation of LKB1/AMPK signaling in the process of cerebral ischemia injury
- AICAR-mediated AMPK activation induces protective innate responses in bacterial endophthalmitis
- Anti-malarial Drugs Reduce Vascular Smooth Muscle Cell Proliferation via Activation of AMPK and Inhibition of Smad3 Signaling
- 13-Methylberberine reduces HMGB1 release in LPS-activated RAW264. 7 cells and increases the survival of septic mice through AMPK/P38 MAPK activation
- … stress, mitochondrial dysfunction and endoplasmic reticulum stress in retinal pigment epithelial cells via triggering Ca2+/CaMKII-dependent activation of AMPK
- Context-dependent AMPK activation distinctly regulates TAp73 stability and transcriptional activity
- mTOR activation due to APPL1 deficiency exacerbates hyperalgesia via Rab5/Akt and AMPK signaling pathway in streptozocin-induced diabetic rats
- Activation of adenosine monophosphate–activated protein kinase (AMPK) enhances energy metabolism, motility, and fertilizing ability of cryopreserved spermatozoa …
- Red pepper seed inhibits differentiation of 3T3-L1 cells during the early phase of adipogenesis via the activation of AMPK
- … via suppression of endoplasmic reticulum stress-associated TXNIP/NLRP3 inflammasome activation and oxidative stress in a AMPK-dependent manner after …
- Oxidative stress and decreased mitochondrial superoxide dismutase 2 and peroxiredoxins 1 and 4 based mechanism of concurrent activation of AMPK and mTOR in …
- … suppresses adipogenesis of 3 T3-L1 preadipocytes by inhibiting CCAAT/enhancer-binding protein β activation and AMPK-mediated mitotic clonal expansion
- Retraction notice to: Resveratrol attenuates lipopolysaccharide-induced dysfunction of blood-brain barrier in endothelial cells via AMPK activation
- Serum is not necessary for prior pharmacological activation of AMPK to increase insulin sensitivity of mouse skeletal muscle
- Involvement of pregnane X receptor in the suppression of carboxylesterases by metformin in vivo and in vitro, mediated by the activation of AMPK and JNK signaling …
- Oocyte activation and latent HIV-1 reactivation: AMPK as a common mechanism of action linking the beginnings of life and the potential eradication of HIV-1
- In silico Analysis of AMP-activated Protein Kinase and Ligand-based Virtual Screening for Identification of Novel AMPK Activators
- Zanthoxylum ailanthoides Suppresses Oleic Acid-Induced Lipid Accumulation through an Activation of LKB1/AMPK Pathway in HepG2 Cells
- Induction of apoptosis by Moutan Cortex Radicis in human gastric cancer cells through the activation of caspases and the AMPK signaling pathway
- Optimization of metabolic and renal clearance in a series of indole acid direct activators of 5′-adenosine monophosphate-activated protein kinase (AMPK)
- … skeletal muscle oxidative metabolism and glucose uptake in association with increased respiratory chain supercomplex formation and AMPK pathway activation
- The effects of evodiamine on serum total cholesterol and triglyceride levels are associated with the activation of the AMPK signaling pathway in rats with hyperlipemia
- Induction of apoptosis by Citrus unshiu peel in human breast cancer MCF-7 cells: involvement of ROS-dependent activation of AMPK
- Ethanol Extract of Pinus koraiensis Leaf Ameliorates Alcoholic Fatty Liver via the Activation of LKB1–AMPK Signaling In Vitro and In Vivo
- Activation of AMPK restricts Zika virus replication in endothelial cells by potentiating antiviral response and inhibiting viral-induced glycolysis
- Cell-to-cell variability in AMPK activation reveals autonomous cycles in cellular energy balance
- Rethinking the regulation of l-carnitine transport in skeletal muscle cells. Focus on “Multiple AMPK activators inhibit l-carnitine uptake in C2C12 skeletal muscle …
- Compound 13, an α1-selective small molecule activator of AMPK, potently inhibits melanoma cell proliferation
- Preparation of benzofuran derivatives for use as AMPK activators
- … metabolic stress-induced cardiac injury through improving insulin resistance (IR) injury and endoplasmic reticulum (ER) stress by promoting AMPK-alpha activation
- Betaine promotes LKB1-AMPK activation inhibits UVB-mediated senescence of human epidermal keratinocytes through autophagy induction
- … induce protective autophagy in human prostate cancer cells via induction of the oncogenic protein AEG-1 and activation of AMP-activated protein kinase (AMPK)
- The energy sensing LKB 1–AMPK α1 pathway regulates IGF 1 secretion and consequent activation of the IGF 1R–PKB pathway in primary hepatocytes
- MicroRNA‐155 inhibition up‐regulates LEPR to inhibit osteoclast activation and bone resorption via activation of AMPK in alendronate‐treated osteoporotic mice
- Sestrin 2 attenuates rat hepatic stellate cell (HSC) activation and liver fibrosis via an mTOR/AMPK-dependent mechanism
- AlterAtiOn Of CYP3A1 mrnA level in PrimArY rAt HePAtOCYtes in resPOnse tO AmPK ACtivAtOr AiCAr
- PXL770, a novel direct AMPK activator, improves metabolic disorders in a diet-induced mice model of obesity and diabetes
- Ethanol extracts of Mori folium inhibit adipogenesis through activation of AMPK signaling pathway in 3T3-L1 preadipocytes
- Effect of Hugan Qingzhi tablets on AMPK pathway activation and NF-κB-p65 protein expression in the liver of rats with nonalcoholic fatty liver disease
- The flavonoid derivative 4′-nitro-6-hydroxyflavone suppresses the activity of HNF4α and stimulates the degradation of HNF4α protein through the activation of AMPK
- PP2A inhibition by LB-100 protects retinal pigment epithelium cells from UV radiation via activation of AMPK signaling
- Protective effect of berberine on oleic acid-induced injury in human aortic endothelial cells via AMPK-eNOS activation.
- … of p70 S6 kinase (S6K1) activity by A77 1726, the active metabolite of leflunomide, induces autophagy through TAK1-mediated AMPK and JNK activation
- Activation of AMPK inhibits medulloblastoma cell growth and Gli1 activity
- Maternal Erythrocyte ENT1-Mediated AMPK Activation and Oxygen Delivery: A Missing Component Counteracting Placental Hypoxia, Dysfunction, and Fetal …
- CAMKK2‐dependent AMPK activation is required to drive cell cycle progression and hepatocyte proliferation after partial hepatectomy in the rat
- … -3-carboxylic acid (PF-06409577) and related indole-3-carboxylic acid derivatives are direct activators of adenosine monophosphate-activated protein kinase (AMPK)
- AMPK activation regulates LTBP4-dependent TGF-b1 secretion by pro-inflammatory macrophages and controls fibrosis in duchenne muscular dystrophy
- FO081 metformin alleviates stroke severity in female mice with chronic kidney disease through AMPK activation and subsequent decrease of microglia/macrophages …
- 4-Hydroxyisoleucine attenuates the inflammation-mediated insulin resistance by the activation of AMPK and suppression of SOCS-3 coimmunoprecipitation with both …
- Research progress on AMPK activators from natural products
- β-GPA: AN AMPK ACTIVATOR WITH POTENTIAL EFFECTS ON HEALTHSPAN AND FUNCTION
- Metformin, an activator of AMPK, promotes the growth of hair follicles via AMPK/β-catenin signaling pathway
- Antidiabetic activity of Callicarpa nudiflora extract in type 2 diabetic rats via activation of the AMPK-ACC pathway
- Ampk Activation Decreases Expression Of Mir-130B In Endothelial Cells
- Statins induce apoptosis in osteosarcoma cells by activation of Ampk and p38-MAPK via suppression of mevalonate pathway
- AMPK activation in the treatment of liver disease
- P01. 04 AMPK activation and glycolysis inhibition protect neural cells from glucose and oxygen restriction
- Brain permeable AMPK activator R481 raises glycemia by autonomic nervous system activation and amplifies the counterregulatory response to hypoglycemia in rats
- Development of small molecule direct AMPK activators for the treatment of cancer
- γ-tocotrienol induces mitophagy in breast cancer cells through activation of LKB1-AMPK pathway
- The Role of AMPK Activation in the Attenuation of Chronic Pain
- Pharmacological Activation of Ampk With a Direct Pan-ampk Activator Results in a Worsening of a Hf Phenotype in Mice
- The hypoxic ventilatory response is facilitated by the activation of Lkb1-AMPK signalling pathways downstream of the carotid bodies
- Deciphering the Mechanisms of AMPK Activation upon Anchorage-Deprivation
- Paeonia japonica ameliorates oxidative stress-induced liver injury through activation of AMPK-mediated GSK3β
- Anti-inflammatory Effect of AMPK Activators from Natural Products in RAW 264.7 Cell Model (P06-095-19)
- Honokiol attenuates lipopolysaccharide-induced acute respiratory distress syndrome via activation of mitochondrion-dependent Sirt3/AMPK pathway
- Activation of transient receptor potential vanilloid 4 impairs the dendritic arborization of newborn neurons in the hippocampal dentate gyrus through the AMPK …
- Effect of AMPK activation on the related factors of vascular injury repair.
- Extracellular calcium influx promotes antibacterial autophagy in Escherichia coli infected murine macrophages via CaMKKβ dependent activation of ERK1/2, AMPK …
- Complement component C1q regulates AMPK and ERK1/2 activation in mouse and human macrophages
- 12,23-Dione dammarane triterpenes from Gynostemma longipes and their muscle cell proliferation activities via activation of the AMPK pathway
- AMPK Activators as Novel Drug Candidates for the Treatment of Inflammatory Bowel Diseases
- … glucagon-like peptide-1 prevents methylglyoxal-induced apoptosis of beta cells through improving mitochondrial function and suppressing prolonged AMPK activation
- … of Cordyceps sinensis ameliorating renal tubular epithelial cells aging induced by D-galactose via inhibiting autophagy-related AMPK/ULK1 signaling activation
- Preclinical PET imaging of AMPK activation in rats
- Left Ventricular Function in Heart Failure Can Be Improved by AMPK-Activation via Acrp30 Signaling
- Energy Expenditure during Cell Spreading Induces AMPK Activation and Regulates the Mechanoresponse of Stem Cells
- In vitro studies on anti-obesity activity of Korean Memilmuk through AMPK activation
- Neurotensin increases breast cancer proliferation through activation of AMPK
- AMPK Activation Improves Survivability after Toxic Gas Exposure
- Response to ‘Antihyperalgesia effect of AMP-activated protein kinase (AMPK) activators in a mouse model of postoperative pain’
- Research of phytochemical AMPK activators against obesity and development of dietary supplements
- Coenzyme Q10 Attenuates High-fat Diet-induced Non-alcoholic Fatty Liver Disease Through Activation of AMPK Pathway (P06-060-19)
- Preparation of isoindoline derivatives for use as AMPK activators
- Detecting Novel Effects of Exercise or AMPK Activation in Human Skeletal Muscle
- Identification of MAP30 as a natural AMPK activator in targeting the tumorigenicity and chemoresistance of ovarian cancer cells
- AMPK-activation reduces EDH-type relaxations in rat small arteries
- AMPK activation protects photoreceptors from light-induced degeneration.
- IMQ induced AMPK activation causes translation inhibition and apoptosis but not autophagy
- AMPK Activation for the Treatment of Fuchs Endothelial Corneal Dystrophy
- Investigating the effect of AMPK activation on T cell-mediated anti-tumour immunity
- Effects of AMPK activation on insulin resistance and inflammatory factors in rats with chronic intermittent hypoxia
- Exercise improves outcomes of surgery on fatty liver and can be substituted through AMPK activation–An experimental study
- Research Article Synthesis and In Vitro AMPK Activation of Cycloalkyl/Alkarylbiguanides with Robust In Vivo Antihyperglycemic Action
- Novel Dual MTOR Inhibitors/AMPK Activators Attenuate Doxorubicin-Induced Cardiotoxicity
- A novel AMPK activator from Chinese herb medicine and ischemia phosphorylate the cardiac transcription factor FOXO3
- … Into The Cardiovascular Disease (CVD) Phenotypes Underlying Increased Susceptibility To Cardiac Remodeling During Menopause With A Focus On AMPK Activator …
- A New Synthetic FRET Sensor to Analyze Allosteric AMPK Activation and Cellular Energy State
- Acute Stress Diminishes M‐Current in Corticotrophin‐Releasing Hormone Neurons through AMPK Activation
- FND 4b decreases proliferation and increases apoptosis of triple negative breast cancer through AMPK activation
- Novel direct AMPK activator suppresses non-small cell lung cancer through inhibition of lipid metabolism
- Ampk Activators Reduces Cigarette Smoke-Induced Inflammatory Responses And Elastase-Induced Mouse Emphysema
- Hexokinase II Localization is Independent of AMPK Activation in HeLa Cells
- Abstract LB-A02: AMPK activation by metformin promotes survival of dormant ER+ breast cancer cells
- AMPK activator alleviates TNF-α-induced fulminant liver injury in mice.
- PXL770, a Novel Direct AMPK Activator, Inhibits Hepatic de novo Lipogenesis for the Treatment of Metabolic Disorders
- AMPK Activation Attenuates Albumin-induced Alterations in Renal Tubular Cells In Vitro
- AMPK activator down-regulates the expression of tissue factor in fulminant hepatitis mice
- Diet Control Diet to Achieve Euglycemia Induces Tau Hyperphosphorylation Via AMPK Activation in the Hippocampus of Diabetic Rats
- Retraction: Berberine Improves Kidney Function in Diabetic Mice via AMPK Activation
- A70 THE GOOD, THE BAD, AND THE UGLY OF AGING: Ampk Activators Reduces Cigarette Smoke-Induced Inflammatory Responses And Elastase-Induced Mouse …
- Losartan inhibits LPS-induced GFAP expression via AMPK activation in mouse hippocampus
- AMPK Activation by Zyflamend: A novel pathway regulating metabolism and growth in prostate cancer
- NADPH Oxidase and Xanthine Oxidase Inhibition Attenuates the Activation of AMPK Signaling After a Single Bout of Endurance Exercise in Mouse Skeletal Muscle
- Multiple AMPK activators inhibit L-Carnitine uptake in C2C12 skeletal muscle myotubes. 2
- Hippocampal AMPK activation suppresses depressive-like behavior in olfactory bulbectomized mice
- Evidence that the AMPK activator, Metformin, induced protection of the retina and RPE through metabolic reprogramming
- Fructooligosaccharides induce tight junction assembly in intestinal epithelial cells via AMPK activation
- AMPK-ARE ACTIVATORS OR INHIBITORS REQUIRED FOR CANCER TREATMENT?
- Exogenous pyruvate potentiates mesodermal differentiation through AMPK activation in human embryonic stem cells
- … -5H-thieno [3′, 2′: 3, 4] pyrido [1, 2-b] isoquinolines as novel adenosine 5′-monophosphate-activated protein kinase (AMPK) indirect activators for the treatment of …
- γ-Tocotrienol negative modulation of the Warburg effect is mediated by the AMPK activation in malignant breast cancer cells
- Capsaicin Targets Lipogenesis in HepG2 Cells Through AMPK Activation, AKT Inhibition and PPARs Regulation
- Prior Treatment with the AMPK Activator AICAR Induces Subsequently Enhanced Glucose Uptake in Isolated Skeletal Muscles from Old Rats
- Glucose consumption assay discovered a novel compound from natural product with beneficial effects on diabetic mice via AMPK activation
- Recovery of Immune Homeostasis Via AMPK Activation in Spite of Parkin-Deficiency in Mice with Sepsis-Induced Immunosuppression
- Divergent effects of DHA treatment and AMPK activation on protein synthesis rate and signaling in palmitate‐treated skeletal muscle
- AMPK Activation in Human Skeletal Muscle Is Fiber Type-Specific following Acute High Intensity Interval Exercise
- AMPK Activation by Acute Endurance Exercise Controls PPARβ/δ Expression through MEF2A
- Cardiac myocyte-specific expression of beta3-adrenergic receptors sustains AMPK activation and glucose uptake while reducing hypertrophy following pressure …
- Regulation of AMPK Activation and Its Role in Cell Death Induced by Glucose Starvation in LKB1-Mutant Human Lung Cancer Cells
- Inhibition of H1299 Human Lung Cancer Cell Proliferation and Survival by Carnosic Acid is Associated with Akt Inhibition and AMPK Activation.
- Metformin, an AMPK Activator, Inhibits Radiation-Induced Skin Damage Via the FOXO3
- The AMPK Activators AICAR and A769662 Reduce Relaxations of Rat Superior Mesenteric Arteries attributable to Endothelium‐dependent Hyperpolarization
- Withdrawn: Safranal induces autophagy by AMPK activation and protects neurons against amyloid beta in Alzheimer’s disease
- AMPK-activation reduces relaxations attributable to the opening of potassium channels in endothelial and smooth muscle cells of the rat superior mesenteric artery
- AMPK activation by P2X7 through ROS-CaMKK pathway regulates mitophagy and lysosomal biogenesis in macrophages
- Red Ginseng Alters Lipid Metabolism through AMPK Activation in Liver and Adipose Tissues of High-Fat Diet-Fed Mice
- Bitter melon (Momordica charantia) extract functions as a natural AMPK activator and synergistically enhances cisplatin cytotoxicity in ovarian cancer cells
- Protection of berberine on intestinal mucosa following autologous orthotropic liver transplantation and its correlationship with p-AMPK activation and p-mTOR …
- Flufenamic Acid Prevents Vibrio cholerae El Tor Variant‐Induced Diarrhea via AMPK Activation and Suppression of NF‐κB‐Mediated Inflammation
- Gallotannin induces senescence and autophagy leading to cell death via SIRT1 inhibition and AMPK activation in hepatocellular carcinoma cells
- Metformin, an Activator of AMPK, Promotes the Growth of Hair Follicles via the AMPK/β-catenin Signaling Pathway
- Activation of AMPK by Metformin Attenuates Marginal Graft Injury via Promoting Mitochondrial Biogenesis
- Research Article Zanthoxylum ailanthoides Suppresses Oleic Acid-Induced Lipid Accumulation through an Activation of LKB1/AMPK Pathway in HepG2 Cells
- Tamoxifen Sensitizes Gallbladder Cancer to Cisplatin Resistance by Impaired Glucose Metabolism via Activation of AMPK Signaling
- (301) Pharmacological activation of AMPK inhibits incision-evoked mechanical hypersensitivity and the transition to a chronic pain state
- Transient Activation of AMPK Prior to Cardiac Pressure Overload Alleviates Fibrotic Accumulation and Functional Decline
- Activation of AMPK Inhibits Hyperpolarization-Mediated Relaxations in Rat Superior Mesenteric Arteries
- Berberine protected RPE cells from H2O2 induced oxidative stress via the activation of the AMPK pathway
- Berberine protected RPE cells from H2O2 induced cell injury via the activation of the AMPK pathway
- Abeta42 oligomers trigger synaptic loss through AMPK-dependent activation of mitochondrial fission and mitophagy
- Postexercise improvement in glucose uptake occurs concomitant with greater γ3-AMPK 1 activation and AS160 phosphorylation in rat skeletal muscle 2
- Activation of AMPK pathway is involved in the protection of Metformin on PC12 cells and hippocampal neurons against H2O2-induced oxidative damage
- Metformin Displays Cardioprotection in δ-sarcoglycan Deficiency Induced Cardiomyopathy Through Autophagic Activation via AMPK-mTOR Pathway
- Correction to: A Dual AMPK/Nrf2 Activator Reduces Brain Inflammation After Stroke by Enhancing Microglia M2 Polarization by Wang Y, Huang Y, Xu Y, Ruan W …
- The combination of Korean red ginseng and Glycyrrhiza glabra L. extracts enhances AMPK pathway activation in C57BL/6J obese mice
- The Natural Flavone Acacetinslows the Development of Atherosclerosis by Sirt3-Mediated Activation of AMPK Signaling Pathway in Diabetic ApoE Null Mice
- Induction of Apoptosis and Autophagy by Resveratrol via Activation of AMPK Pathway in 5-Fluorouracil-Resistant Colon Cancer Cells
- GW28-e0091 CTRP9 Alleviates Hypoxia-Induced Cardiomyocytes Injury by Inducing Autophagy Via the AMPK Signaling Activation
- Activation of AMPK‐FoxO3a pathway mediated autophagy inhibits fibroblast‐myofibroblast differentiation in pulmonary fibrosis
- THU0053 Selective activation of an AMPK-CREB-NRF2-dependent pathway by celecoxib induces vasculoprotective genes and mitigates against cardiovascular risk
- Pentamethylquercetin counteracts obesity and drives brown fat-like phenotype through AMPK-mediated activation of PGC-1 alpha/FNDC5 pathway in muscle
- Artemisinin protected human SH-SY5Y and hippocampal neurons from hydrogen peroxide (H2O2)-induced oxidative damage through the activation of the AMPK …
- Oleuropein ameliorates palmitate-induced insulin resistance by increasing Glut4 translocation through activation of AMPK
- Autophagy Activation by Leptin Mediates the Growth of Breast Cancer Cells via Estrogen Receptor Signaling: Involvement of AMPK/FoxO3A Axis
- Gamma Tocotrienol Suppresses NLRP3 Inflammasome by Dual Mechanism of A20‐mediated Priming Inhibition and AMPK/autophagy Axis Activation
- LKB1/AMPK/M-TOR response to ischemia in high metabolic rate tissues: A comparison between the brain, heart, kidney and liver intracellular metabolic axis activation …
- … effect of Metformin against H2O2-induced oxidative damage in human retinal pigment epithelial (RPE) cells through activation of AMPK/mTOR/Autophagy pathway
- Artemether Activation of AMPK/GSK3β (ser9)/Nrf2 Signaling Confers Neuroprotection towards β-Amyloid-Induced Neurotoxicity in 3xTg Alzheimer’s Mouse Model
- Genetic Deletion of Elovl6 in Cardiac Myocytes Suppresses Pressure Overload-Induced Cardiac Hypertrophy and Remodeling Through Activation of AMPK/KLF4 …
- AMP-activated protein kinase activator A-769662 increases intracellular calcium and ATP release from astrocytes in an AMPK-independent manner
- 516-P: Preventive Effect of Sulforaphane on Type 2 Diabetes-Induced Diabetic Nephropathy via AMPK-Mediated Activation of Glucose/Lipid Metabolism and Nrf2 …
- 613-P: Preventive Effect of Sulforaphane on Type 2 Diabetes-Induced Diabetic Cardiomyopathy via AMPK-Mediated Activation of Glucose/Lipid Metabolism and Nrf2 …
- Skeletal Muscle LKB1/SIRT3-AMPK-GLUT4 Activation by Treprostinil and Metformin Normalizes Hyperglycemia and Improves Cardiac Function in Pulmonary …
- … enhancing virus replication via activation of phosphatase and tensin deleted on chromosome 10 (PTEN) and AMP-activated protein kinase (AMPK), as well as dsRNA …
- The circular RNA NRIP1 plays oncogenic roles by targeting miR-505 through the activation of AMPK and PI3K/AKT/mTOR pathways in the renal carcinoma cell lines
- Stromal Cell-derived Factor-1 Prevents From Diabetic Cardiomyopathy via Cxcr7/ampk-mediated Nrf2 Activation in Type 2 Diabetic Mice
- 1822: ACTIVATION OF STAT3 REDUCES SPLANCHNIC ISCHEMIA/REPERFUSION INJURY IN AN AMPK-INDEPENDENT MANNER
- Mitochondrial adenylate kinase 4 regulates dual AMPK and mTORC1 activation
- MP39-18 MITOCHONDRIA FUNCTION CHANGE AND ACTIVATION OF AMPK-PGC1? PATHWAY THROUGH INDUCTION OF CLEAR CYTOPLASM IN RENAL CELL …
- 451-P: SGLT2 Inhibitor Protects Cardiomyocytes against Palmitate-Induced Lipotoxicity by Increasing Activation of AMPK and Lipid Oxidations
- Regulatation of Type 2 Diabetes Mellitus-Induced Non-Alcoholic Fatty Liver Disease through Activation of AMPK and PPAR-α by Black Ginseng
- AICAr, a widely used AMPK activator with important AMPK-independent effects: a systematic review
- The bewildering effect of AMPK activators in Alzheimer’s disease: review of the current evidence
- New insights into activation and function of the AMPK
- Energy-stress-mediated AMPK activation inhibits ferroptosis
- Factors influencing AMPK activation during cycling exercise: a pooled analysis and meta-regression
- AMPK in microvascular complications of diabetes and the beneficial effects of AMPK activators from plants
- The role of AMPK activation for cardioprotection in doxorubicin-induced cardiotoxicity
- ALDOA maintains NLRP3 inflammasome activation by controlling AMPK activation
- Structure-function analysis of the AMPK activator SC4 and identification of a potent pan AMPK activator
- The metformin mechanism on gluconeogenesis and AMPK activation: the metabolite perspective
- Empagliflozin protects heart from inflammation and energy depletion via AMPK activation
- Direct AMPK activation corrects NASH in rodents through metabolic effects and direct action on inflammation and fibrogenesis
- Natural AMPK activators in cardiovascular disease prevention
- AMPK activation by ASP4132 inhibits non-small cell lung cancer cell growth
- Metformin, an AMPK activator, inhibits activation of FLSs but promotes HAPLN1 secretion
- Targeting breast cancer and their stem cell population through AMPK activation: Novel insights
- Annexin A1 drives macrophage skewing to accelerate muscle regeneration through AMPK activation
- AMPK activator O304 protects against kidney aging through promoting energy metabolism and autophagy
- AMPK Activation by Metformin Promotes Survival of Dormant ER+ Breast Cancer Cells
- Activation of AMPK under hypoxia: many roads leading to Rome
- Hypoglycemic and hypolipidemic effects of blueberry anthocyanins by AMPK activation: In vitro and in vivo studies
- AMPK activators for the prevention and treatment of neurodegenerative diseases
- AMPK activation protects against prostate cancer by inducing a catabolic cellular state
- Mogrol, an aglycone of mogrosides, attenuates ulcerative colitis by promoting AMPK activation
- IQGAP1 binds AMPK and is required for maximum AMPK activation
- Licochalcone d ameliorates oxidative stress-induced senescence via ampk activation
- Stigmasterol attenuates inflammatory response of microglia via NF-κB and NLRP3 signaling by AMPK activation
- Spermidine endows macrophages anti-inflammatory properties by inducing mitochondrial superoxide-dependent AMPK activation, Hif-1α upregulation and …
- Neuroprotective and vision‐protective effect of preserving ATP levels by AMPK activator
- Ginsenoside-Rg2 affects cell growth via regulating ROS-mediated AMPK activation and cell cycle in MCF-7 cells
- Direct small molecule ADaM-site AMPK activators reveal an AMPKγ3-independent mechanism for blood glucose lowering
- AMPK activation induces mitophagy and promotes mitochondrial fission while activating TBK1 in a PINK1‐Parkin independent manner
- AdipoRon induces AMPK activation and ameliorates Alzheimer’s like pathologies and associated cognitive impairment in APP/PS1 mice
- Ganoderma lucidum Extract Reduces Insulin Resistance by Enhancing AMPK Activation in High-Fat Diet-Induced Obese Mice
- The Degradation of TMEM166 by Autophagy Promotes AMPK Activation to Protect SH-SY5Y Cells Exposed to MPP+
- AMPK activator decelerates osteoarthritis development by inhibition of β-catenin signaling in chondrocytes
- Carnosol inhibits cerebral ischemia-reperfusion injury by promoting AMPK activation
- Ginsenoside-Rg2 exerts anti-cancer effects through ROS-mediated AMPK activation associated mitochondrial damage and oxidation in MCF-7 cells
- Protective effects of heterophyllin B against bleomycin-induced pulmonary fibrosis in mice via AMPK activation
- AMPK activation reverts mouse epiblast stem cells to naive state
- Genistein stimulates insulin sensitivity through gut microbiota reshaping and skeletal muscle AMPK activation in obese subjects
- TRPM7 silencing modulates glucose metabolic reprogramming to inhibit the growth of ovarian cancer by enhancing AMPK activation to promote HIF-1α …
- Mechanism of activation of AMPK by cordycepin
- The insulin-sensitizing mechanism of myo-inositol is associated with AMPK activation and GLUT-4 expression in human endometrial cells exposed to a PCOS …
- A novel AMPK activator shows therapeutic potential in hepatocellular carcinoma by suppressing HIF1α‐mediated aerobic glycolysis
- An AMPK activator as a therapeutic option for congenital nephrogenic diabetes insipidus
- Total flavonoids in Epimedium koreanum Nakai alleviated chronic renal failure via promoting AMPK activation
- AMPK Activation: Respiratory Panacea?
- Dietary nucleotides alleviate hepatic lipid deposition via exogenous AMP-mediated AMPK activation in zebrafish
- AMPK activation overcomes anti-EGFR antibody resistance induced by KRAS mutation in colorectal cancer
- Effects of vitamin D supplementation on adipose tissue inflammation and NF-κB/AMPK activation in obese mice fed a high-fat diet
- AMPK activator O304 improves metabolic and cardiac function, and exercise capacity in aged mice
- Metformin alleviates oxidative stress‐induced senescence of human lens epithelial cells via AMPK activation and autophagic flux restoration
- Sargassum thunbergii Extract Attenuates High-Fat Diet-Induced Obesity in Mice by Modulating AMPK Activation and the Gut Microbiota
- Metformin suppresses cancer stem cells through AMPK activation and inhibition of protein prenylation of the mevalonate pathway in colorectal cancer
- Energy-stress-mediated AMPK activation promotes GPX4-dependent ferroptosis through the JAK2/STAT3/P53 axis in renal cancer
- Insulin-independent stimulation of skeletal muscle glucose uptake by low-dose abscisic acid via AMPK activation
- Pyrroloquinoline quinone promotes mitochondrial biogenesis in rotenone-induced Parkinson’s disease model via AMPK activation
- Aucubin prevents steroid‐induced osteoblast apoptosis by enhancing autophagy via AMPK activation
- Geniposide improves diabetic nephropathy by enhancing ULK1-mediated autophagy and reducing oxidative stress through AMPK activation
- Knockdown of LKB1 sensitizes endometrial cancer cells via AMPK activation
- Increasing SnRK1 activity with the AMPK activator A-769662 accelerates seed germination in rice
- Pharmacological activation of pyruvate kinase M2 reprograms glycolysis leading to TXNIP depletion and AMPK activation in breast cancer cells
- Selective AMPK activator leads to unfolded protein response downregulation and induces breast cancer cell death and autophagy
- PIM kinases inhibit AMPK activation and promote tumorigenicity by phosphorylating LKB1
- TNF-induced necroptosis initiates early autophagy events via RIPK3-dependent AMPK activation, but inhibits late autophagy
- Resistance to FGFR1-targeted therapy leads to autophagy via TAK1/AMPK activation in gastric cancer
- AMPK activation does not enhance autophagy in neurons in contrast to MTORC1 inhibition: different impact on β-amyloid clearance
- Energy deprivation-induced AMPK activation inhibits milk synthesis by targeting PrlR and PGC-1α
- Hesperidin attenuates hepatic lipid accumulation in mice fed high-fat diet and oleic acid induced HepG2 via AMPK activation
- p-Coumaric Acid Enhances Hypothalamic Leptin Signaling and Glucose Homeostasis in Mice via Differential Effects on AMPK Activation
- CDC25B partners with PP2A to induce AMPK activation and tumor suppression in triple negative breast cancer
- MK8722, an AMPK activator, inhibiting carcinoma proliferation, invasion and migration in human pancreatic cancer cells
- Papain ameliorates lipid accumulation and inflammation in high-fat diet-induced obesity mice and 3T3-L1 adipocytes via AMPK activation
- Effect of AMPK activation and glucose availability on myotube LAT1 expression and BCAA utilization
- Arsenic induces autophagy-dependent apoptosis via Akt inactivation and AMPK activation signaling pathways leading to neuronal cell death
- Irisin induces trophoblast differentiation via AMPK activation in the human placenta
- Shikonin attenuates hepatic steatosis by enhancing beta oxidation and energy expenditure via AMPK activation
- Pan-AMPK activator O304 prevents gene expression changes and remobilisation of histone marks in islets of diet-induced obese mice
- AMPK activator C24 inhibits hepatic lipogenesis and ameliorates dyslipidemia in HFHC diet-induced animal models
- Evaluating the impact of AMPK activation, a target of metformin, on risk of cardiovascular diseases and cancer in the UK Biobank: a Mendelian randomisation …
- Effects of the peripheral CB1 receptor antagonist JD5037 in mono—and polytherapy with the AMPK activator metformin in a monocrotaline-induced rat model …
- Metformin reduces TRPC6 expression through AMPK activation and modulates cytoskeleton dynamics in podocytes under diabetic conditions
- Obligatory Role of AMPK Activation and Antioxidant Defense Pathway in the Regulatory Effects of Metformin on Cellular Protection and Prevention of Lens Opacity
- In Silico and In Vitro Approach to Assess Direct Allosteric AMPK Activators from Nature
- AMPK activators have compound and concentration‐specific effects on brain metabolism
- Piperlongumine synergistically enhances the antitumour activity of sorafenib by mediating ROS-AMPK activation and targeting CPSF7 in liver cancer
- Antitumor effect of morusin via G1 arrest and antiglycolysis by AMPK activation in hepatocellular cancer
- The role of AMPK signaling in brown adipose tissue activation
- … bayberry leaves reduce obesity and associated metabolic disorders in high-fat diet-induced obese mice through a combination of AMPK activation and an alteration …
- TLR9 and beclin 1 crosstalk regulates muscle AMPK activation in exercise
- GAS6/Axl is associated with AMPK activation and attenuates H2O2-induced oxidative stress
- Rice bran phenolic extract supplementation ameliorates impaired lipid metabolism in high-fat-diet fed mice through AMPK activation in liver
- Protein kinase A negatively regulates VEGF-induced AMPK activation by phosphorylating CaMKK2 at serine 495
- AMPK activation protects astrocytes from hypoxia‑induced cell death
- Novel Aza-podophyllotoxin derivative induces oxidative phosphorylation and cell death via AMPK activation in triple-negative breast cancer
- Mogroside V protects against hepatic steatosis in mice on a high-fat diet and LO2 cells treated with free fatty acids via AMPK activation
- Carnosic acid prevented olanzapine-induced metabolic disorders through AMPK activation
- TFAM depletion overcomes hepatocellular carcinoma resistance to doxorubicin and sorafenib through AMPK activation and mitochondrial dysfunction
- … X Receptor Overexpression Decreases the Migration, Invasion and Angiogenesis of Human Bladder Cancers via AMPK Activation and Cholesterol Biosynthesis …
- Orchestrated action of AMPK activation and combined VEGF/PD-1 blockade with lipid metabolic tunning as multi-target therapeutics against ovarian cancers
- Nifedipine-induced AMPK activation alleviates senescence by increasing autophagy and suppressing of Ca2+ levels in vascular smooth muscle cells
- Berbamine induced AMPK activation regulates mTOR/SREBP-1c axis and Nrf2/ARE pathway to allay lipid accumulation and oxidative stress in steatotic HepG2 cells
- The protein tyrosine phosphatase PTP-PEST mediates hypoxia-induced endothelial autophagy and angiogenesis via AMPK activation
- AMPK activation restores salivary function following radiation treatment
- AMPK activation alleviates myocardial ischemia-reperfusion injury by regulating Drp1-mediated mitochondrial dynamics
- Ginger extract controls mTOR-SREBP1-ER stress-mitochondria dysfunction through AMPK activation in obesity model
- The combination of cinnamaldehyde and kaempferol ameliorates glucose and lipid metabolism disorders by enhancing lipid metabolism via AMPK activation
- Acute, next‐generation AMPK activation initiates a disease‐resistant gene expression program in dystrophic skeletal muscle
- Red Pepper Seeds Inhibit Hepatic Lipid Accumulation by Inducing Autophagy via AMPK Activation
- Catalpol-induced AMPK activation alleviates cisplatin-induced nephrotoxicity through the mitochondrial-dependent pathway without compromising its …
- … Mix of Polyphenols and Micronutrients Reduces Adipogenesis and Promotes White Adipose Tissue Browning via UCP1 Expression and AMPK Activation
- Trans‐gnetin H isolated from the seeds of Paeonia species induces autophagy via inhibiting mTORC1 signalling through AMPK activation
- Adiponectin restrains ILC2 activation by AMPK-mediated feedback inhibition of IL-33 signaling
- Glutamine in suppression of lipopolysaccharide-induced piglet intestinal inflammation: The crosstalk between AMPK activation and mitochondrial function
- Discovery of AdipoRon analogues as novel AMPK activators without inhibiting mitochondrial complex I
- Diosmetin alleviates hypoxia‑induced myocardial apoptosis by inducing autophagy through AMPK activation
- Metformin-induced AMPK activation promotes cisplatin resistance through PINK1/Parkin dependent mitophagy in gastric cancer
- … inhibits adipogenesis in 3T3-L1 adipocytes by regulating adipogenic transcription factors and adenosine monophosphate-activated protein kinase (AMPK) activation
- AMPK activator AICAR in combination with anti-mouse IL10 mAb restores the functionality of intra-tumoral Tfh cells in the 4T1 mouse model
- Eupatilin suppresses pancreatic cancer cells via glucose uptake inhibition, AMPK activation, and cell cycle arrest
- Acute nicotine treatment alleviates LPS-induced impairment of fear memory reconsolidation through AMPK activation and CRTC1 upregulation in hippocampus
- Metformin limits osteoarthritis development and progression through activation of AMPK signalling
- Identification of novel indole derivatives as highly potent AMPK activators with anti-diabetic profiles
- Chronic AMPK Activation Reduces the Expression and Alters Distribution of Synaptic Proteins in Neuronal SH-SY5Y Cells
- Maternal erythrocyte ENT1–mediated AMPK activation counteracts placental hypoxia and supports fetal growth
- Anisomycin inhibits angiogenesis, growth, and survival of triple-negative breast cancer through mitochondrial dysfunction, AMPK activation, and mTOR inhibition
- Sustained activation of AMPK enhances differentiation of human iPSC-derived cardiomyocytes via sirtuin activation
- Higenamine attenuates doxorubicin-induced cardiac remodeling and myocyte apoptosis by suppressing AMPK activation
- Astaxanthin stimulates mitochondrial biogenesis in insulin resistant muscle via activation of AMPK pathway
- AMPK activation in pregnant human myometrial arteries from high-altitude and intrauterine growth-restricted pregnancies
- Anti-diabetic effects of linarin from Chrysanthemi Indici Flos via AMPK activation
- LncRNA Chaer prevents cardiomyocyte apoptosis from acute myocardial infarction through AMPK activation
- Prenylflavonoids from fruit of Macaranga tanarius promote glucose uptake via AMPK activation in L6 myotubes
- Pre-clinical evidence that salinomycin is active against retinoblastoma via inducing mitochondrial dysfunction, oxidative damage and AMPK activation
- Ethanol Extract of Rosa laevigata Michx. Fruit Inhibits Inflammatory Responses through NF-κB/MAPK Signaling Pathways via AMPK Activation in RAW 264.7 …
- AMPK Activation Is Important for the Preservation of Insulin Sensitivity in Visceral, but Not in Subcutaneous Adipose Tissue of Postnatally Overfed Rat Model of …
- AMPK S-sulfuration contributes to H2S donors-induced AMPK phosphorylation and autophagy activation in dopaminergic cells
- … an Active Cyclopeptide Alleviates Dextran Sulfate Sodium‐Induced Colitis by Modulating Gut Microbiota and Repairing Intestinal Mucosal Barrier via AMPK Activation
- Hypolipidemic effects of macadamia oil are related to AMPK activation and oxidative stress relief: In vitro and in vivo studies
- Paradoxical activation of AMPK by glucose drives selective EP300 activity in colorectal cancer
- AMPK activation is indispensable for the protective effects of caloric restriction on left ventricular function in postinfarct myocardium
- Sleeve gastrectomy-induced AMPK activation attenuates diabetic cardiomyopathy by maintaining mitochondrial homeostasis via NR4A1 suppression in rats
- Mineral trioxide aggregate‐induced AMPK activation stimulates odontoblastic differentiation of human dental pulp cells
- … and glucose metabolism by glycosylated kaempferol rich roasted leaves of Lycium chinense via upregulating adiponectin and AMPK activation in obese mice …
- AMPK activation by dietary AICAR affects the growth performance and glucose and lipid metabolism in juvenile grass carp
- … component Moscatilin mitigates Glycation-mediated damages in an SH-SY5Y cell model of neurodegenerative diseases through AMPK activation and RAGE/NF-κ B …
- Modeling Structure–Activity Relationship of AMPK Activation
- Natural product mogrol attenuates bleomycin-induced pulmonary fibrosis development through promoting AMPK activation
- N-butylidenephthalide ameliorates high-fat diet-induced obesity in mice and promotes browning through adrenergic response/AMPK activation in mouse beige …
- Broussonetia papyrifera Root Bark Extract Exhibits Anti-inflammatory Effects on Adipose Tissue and Improves Insulin Sensitivity Potentially Via AMPK Activation
- Mitochondrial dysfunction, AMPK activation and peroxisomal metabolism: A coherent scenario for non-canonical 3-methylglutaconic acidurias
- Metformin ameliorates chronic colitis in a mouse model by regulating interferon‐γ‐producing lamina propria CD4+ T cells through AMPK activation
- Cardioprotective effects of melatonin against myocardial ischaemia/reperfusion injury: Activation of AMPK/Nrf2 pathway
- Effective fraction from Simiao Wan prevents hepatic insulin resistant by inhibition of lipolysis via AMPK activation
- AMPK-dependent phosphorylation is required for transcriptional activation of TFEB and TFE3
- Neuroprotective effect of IND1316, an indole-based AMPK activator, in animal models of Huntington disease
- Increased oxidative stress contributes to enhance brain amyloidogenesis and blunts energy metabolism in sucrose-fed rat: Effect of AMPK activation
- AMPK activation by SC4 inhibits noradrenaline-induced lipolysis and insulin-stimulated lipogenesis in white adipose tissue
- Activation of the AMP-related kinase (AMPK) induces renal vasodilatation and downregulates Nox-derived reactive oxygen species (ROS) generation
- AMPK-dependent activation of the Cyclin Y/CDK16 complex controls autophagy
- Phthalide derivative CD21 alleviates cerebral ischemia-induced neuroinflammation: involvement of microglial M2 polarization via AMPK activation
- Translation initiation factor eIF3a regulates glucose metabolism and cell proliferation via promoting small GTPase Rheb synthesis and AMPK activation
- Photobiomodulation reduces hepatic lipogenesis and enhances insulin sensitivity through activation of CaMKKβ/AMPK signaling pathway
- AMPK activation alleviated DSS‐induced colitis by inhibiting ferroptosis
- AMPK activation ameliorates fine particulate matter-induced hepatic injury
- Rosmarinic acid improves boar sperm quality, antioxidant capacity and energy metabolism at 17 C via AMPK activation
- Fluid flow-induced activation of subcellular AMPK and its interaction with FAK and Src
- Glucose and Serum Deprivation Led to Altered Proliferation, Differentiation Potential and AMPK Activation in Stem Cells from Human Deciduous Tooth
- AMPK activation induced by promethazine increases NOXA expression and Beclin-1 phosphorylation and drives autophagy-associated apoptosis in chronic …
- Dammarane-type triterpenoids from Gynostemma compressum XX Chen & DR Liang (Cucurbitaceae) and their AMPK activation effect in 3T3-L1 cells
- Adiponectin facilitates postconditioning cardioprotection through both AMPK-dependent nuclear and AMPK-independent mitochondrial STAT3 activation
- Inhibition of basal and glucagon-induced hepatic glucose production by 991 and other pharmacological AMPK activators
- Tschimganidine reduces lipid accumulation through AMPK activation and alleviates high-fat diet-induced metabolic diseases
- Adropin inhibited tilapia hepatic glucose output and triglyceride accumulation via AMPK activation
- Francisella tularensis Exploits AMPK Activation to Harvest Host-Derived Nutrients Liberated from Host Lipolysis
- Pharmacological and exercise‐induced activation of AMPK as emerging therapies for myotonic dystrophy type 1 patients
- Activation of AMPK promotes maturation of cardiomyocytes derived from human induced pluripotent stem cells
- Globular adiponectin ameliorates insulin resistance in skeletal muscle by enhancing the LKB1-mediated AMPK activation via SESN2
- AMPK activation by metformin protects against pulmonary hypertension in rats and relaxes isolated human pulmonary artery
- AMPK and its activator berberine in the treatment of neurodegenerative diseases
- Selenium nanoparticles improve fish sperm quality by enhancing glucose uptake capacity via AMPK activation
- FLT4/VEGFR3 activates AMPK to coordinate glycometabolic reprogramming with autophagy and inflammasome activation for bacterial elimination
- AMPK-dependent phosphorylation of the GATOR2 component WDR24 suppresses glucose-mediated mTORC1 activation
- Citrus peel extract ameliorates high-fat diet-induced NAFLD via activation of AMPK signaling
- Pyrvinium treatment confers hepatic metabolic benefits via β-catenin downregulation and AMPK activation
- Poricoic acid A activates AMPK to attenuate fibroblast activation and abnormal extracellular matrix remodelling in renal fibrosis
- The Impact of Genetically Proxied AMPK Activation, the Target of Metformin, on Functional Outcome Following Ischemic Stroke
- Activation of the AMPK-SIRT1 pathway contributes to protective effects of Salvianolic acid A against lipotoxicity in hepatocytes and NAFLD in mice
- … and ticagrelor have additive effects on the attenuation of the activation of the NLRP3 inflammasome and the progression of diabetic cardiomyopathy: An AMPK …
- Resveratrol downregulates ENaCs through the activation of AMPK in human colon cancer cells
- Activation of AMPK promotes cardiac differentiation by stimulating the autophagy pathway
- Regulatory role of cardiomyocyte metabolism via AMPK activation in modulating atrial structural, contractile, and electrical properties following atrial fibrillation
- AMPK activation attenuates HER3 upregulation and Neuregulin-Mediated rescue of cell proliferation in HER2-Overexpressing breast cancer cell lines exposed to …
- MicroRNA-33/33* inhibit the activation of MAVS through AMPK in antiviral innate immunity
- AMPK activation attenuates cancer-induced bone pain by reducing mitochondrial dysfunction-mediated neuroinflammation: AMPK activation attenuates bone …
- Cordycepin enhances the chemosensitivity of esophageal cancer cells to cisplatin by inducing the activation of AMPK and suppressing the AKT signaling …
- Icariin, the main prenylflavonoid of Epimedii Folium, ameliorated chronic kidney disease by modulating energy metabolism via AMPK activation
- Impacts of altered exercise volume, intensity, and duration on the activation of AMPK and CaMKII and increases in PGC-1α mRNA
- Maternal exercise intergenerationally drives muscle-based thermogenesis via activation of apelin-AMPK signaling
- Paris saponin VII, a direct activator of AMPK, induces autophagy and exhibits therapeutic potential in non-small-cell lung cancer
- … , attenuates obesity, non-alcoholic fatty liver, and insulin resistance Via inhibitions of pancreatic lipase, cAMP-dependent PDE activity, AMPK activation, and SOCS-3 …
- The intraperitoneal administration of MOTS-c produces antinociceptive and anti-inflammatory effects through the activation of AMPK pathway in the mouse formalin …
- Scopoletin increases glucose uptake through activation of PI3K and AMPK signaling pathway and improves insulin sensitivity in 3T3-L1 cells
- Metformin-induced AMPK activation suppresses larval growth and molting probably by disrupting 20E synthesis and glycometabolism in fall webworm, Hyphantria …
- Metformin inhibits abdominal aortic aneurysm formation through the activation of the AMPK/mTOR signaling pathway
- Cordycepin protects against acute pancreatitis by modulating NF-κB and NLRP3 inflammasome activation via AMPK
- Low-dose metformin and PEN2-dependent lysosomal AMPK activation: benefits outnumber side effects
- Anti-inflammatory effects of vinpocetine in LPS-stimulated microglia via activation of AMPK
- A novel zinc chelator, 1H10, ameliorates experimental autoimmune encephalomyelitis by modulating zinc toxicity and AMPK activation
- Lower body weight in rats under hypobaric hypoxia exposure would lead to reduced right ventricular hypertrophy and increased AMPK activation
- Metformin resensitizes sorafenib-resistant HCC cells through AMPK-dependent autophagy activation
- Mitophagy: molecular mechanisms, new concepts on Parkin activation and the emerging role of AMPK/ULK1 Axis
- Herbal Combination of Phyllostachys pubescens and Scutellaria baicalensis Inhibits Adipogenesis and Promotes Browning via AMPK Activation in 3T3-L1 …
- KCNK3 inhibits proliferation and glucose metabolism of lung adenocarcinoma via activation of AMPK-TXNIP pathway
- Activation of AMPK by triptolide alleviates nonalcoholic fatty liver disease by improving hepatic lipid metabolism, inflammation and fibrosis
- Exercise improves lipid droplet metabolism disorder through activation of AMPK-mediated lipophagy in NAFLD
- ABHD5 suppresses cancer cell anabolism through lipolysis-dependent activation of the AMPK/mTORC1 pathway
- Synergistic activation of AMPK prevents from polyglutamine-induced toxicity in Caenorhabditis elegans
- Apigenin alleviates renal fibroblast activation through AMPK and ERK signaling pathways in vitro
- Glucose-6-phosphate dehydrogenase neutralizes stresses by supporting reductive glutamine metabolism and AMPK activation
- The bidirectional relationship between AMPK pathway activation and myokine secretion in skeletal muscle: How it affects energy metabolism
- (-)-Epigallocatechin-3-gallate provides neuroprotection via AMPK activation against traumatic brain injury in a mouse model
- Structural basis of the selective activation of enzyme isoforms: Allosteric response to activators of β1-and β2-containing AMPK complexes
- A single bout of exhaustive treadmill exercise increased AMPK activation associated with enhanced autophagy in mice skeletal muscle
- Regulation of autophagy and apoptosis by Dp44mT-mediated activation of AMPK in pancreatic cancer cells
- … cells against TNF-α-induced inflammation, oxidative stress, and loss of cellular homeostasis by enhancing autophagic flux via AMPK/SIRT1 activation
- Lactobacillus Strains Alleviated Hyperlipidemia and Liver Steatosis in Aging Rats via Activation of AMPK
- Metformin alleviates lead-induced mitochondrial fragmentation via AMPK/Nrf2 activation in SH-SY5Y cells
- Ca2+/Calmodulin-Dependent Protein Kinase II Inhibits Hepatitis B Virus Replication from cccDNA via AMPK Activation and AKT/mTOR Suppression
- Amarogentin inhibits vascular smooth muscle cell proliferation and migration and attenuates neointimal hyperplasia via AMPK activation
- Globular adiponectin inhibits breast cancer cell growth through modulation of inflammasome activation: critical role of Sestrin2 and AMPK signaling
- The Effects of NT-1044, a Novel AMPK Activator, on Endometrial Cancer Cell Proliferation, Apoptosis, Cell Stress and In Vivo Tumor Growth
- Glucose starvation induces autophagy via ULK1-mediated activation of PIKfyve in an AMPK-dependent manner
- Identification of novel benzimidazole derivatives as highly potent AMPK activators with anti-diabetic profiles
- AMPK–mTOR–mediated activation of autophagy promotes formation of dormant polyploid giant cancer cells
- ERK inhibition increases RANKL-induced osteoclast differentiation in RAW 264.7 cells by stimulating AMPK activation and RANK expression and inhibiting anti …
- Dihydromyricetin protects against Doxorubicin-induced cardiotoxicity through activation of AMPK/mTOR pathway
- … from the Seedlings of Various Korean Oat (Avena sativa L.) Cultivars and Screening for Adenosine 5′-Monophosphate-Activated Protein Kinase (AMPK) Activation
- CaMKK2 is not involved in contraction-stimulated AMPK activation and glucose uptake in skeletal muscle
- Adiponectin peptide alleviates oxidative stress and NLRP3 inflammasome activation after cerebral ischemia-reperfusion injury by regulating AMPK/GSK-3β
- Discovery of IHMT-MST1-39 as a novel MST1 kinase inhibitor and AMPK activator for the treatment of diabetes mellitus
- Maternal exercise mediates hepatic metabolic programming via activation of AMPK-PGC1α axis in the offspring of obese mothers
- Policosanol profiles and adenosine 5′-monophosphate-activated protein kinase (AMPK) activation potential of Korean wheat seedling extracts according to cultivar …
- Targeting PP2A with lomitapide suppresses colorectal tumorigenesis through the activation of AMPK/Beclin1-mediated autophagy
- Hydroxycitric Acid Inhibits Chronic Myelogenous Leukemia Growth through Activation of AMPK and mTOR Pathway
- Palmatine protects against cerebral ischemia/reperfusion injury by activation of the AMPK/Nrf2 pathway
- Melatonin ameliorates necrotizing enterocolitis by preventing Th17/Treg imbalance through activation of the AMPK/SIRT1 pathway
- AMP-independent activator of AMPK for treatment of mitochondrial disorders
- Hepatic AMPK signaling dynamic activation in response to REDOX balance are sentinel biomarkers of exercise and antioxidant intervention to improve blood glucose …
- Hesperetin, a SIRT1 activator, inhibits hepatic inflammation via AMPK/CREB pathway
- Metformin alleviates neurocognitive impairment in aging via activation of AMPK/BDNF/PI3K pathway
- Nandrolone Supplementation Promotes AMPK Activation and Divergent 18[FDG] PET Brain Connectivity in Adult and Aged Mice
- Natural (dihydro) phenanthrene plant compounds are direct activators of AMPK through its allosteric drug and metabolite–binding site
- Development of a potent and orally active activator of adenosine monophosphate-activated protein kinase (AMPK), ASP4132, as a clinical candidate for the treatment …
- Cr (VI) induces ROS-mediated mitochondrial-dependent apoptosis in neuronal cells via the activation of Akt/ERK/AMPK signaling pathway
- AMPK/MFF Activation: Role in Mitochondrial Fission and Mitophagy in Dry Eye
- Activation of AMPK/aPKCζ/CREB pathway by metformin is associated with upregulation of GDNF and dopamine
- … and Diospyros kaki Leaf Inhibits White Adipocyte Differentiation and Browning Process through AMP-Activated Protein Kinase (AMPK) Activation In Vitro and …
- Celastrol exerts anti‐inflammatory effect in liver fibrosis via activation of AMPK‐SIRT3 signalling
- The protective role of Zingerone in a murine asthma model via activation of the AMPK/Nrf2/HO-1 pathway
- AMPK-dependent autophagy activation and alpha-Synuclein clearance: a putative mechanism behind alpha-mangostin’s neuroprotection in a rotenone-induced …
- Mitochondrial dysfunction and apoptosis are attenuated through activation of AMPK/GSK-3β/PP2A pathway in Parkinson’s disease
- AMPK/p38/Nrf2 activation as a protective feedback to restrain oxidative stress and inflammation in microglia stimulated with sodium fluoride
- Limonin, an AMPK activator, inhibits hepatic lipid accumulation in high fat diet fed mice
- AMPK activation by AICAR reduces diet induced fatty liver in C57BL/6 mice
- Inhibition of osteosarcoma cell proliferation in vitro and tumor growth in vivo in mice model by alstonine through AMPK-activation and PGC-1α/TFAM up-regulation
- Viral model of maternal immune activation alters placental AMPK and mTORC1 signaling in rats
- AMPK Activation as a Protective Mechanism to Restrain Oxidative Stress in the Insulin-Resistant State in SkeletalMuscle of Rat Model of PCOS Subjected to …
- Hernandezine induces autophagic cell death in human pancreatic cancer cells via activation of the ROS/AMPK signaling pathway
- Quercetin Attenuates Diabetic Peripheral Neuropathy by Correcting Mitochondrial Abnormality via Activation of AMPK/PGC-1α Pathway in vivo and in vitro
- … aggravates acute liver injury by promoting liver‐resident macrophage NLRP 3 inflammasome activation via the inhibition of AMPK/mTOR‐mediated autophagy …
- Therapeutically relevant natural products as AMPK activators in the treatment of diabetes
- AMPK activation is sufficient to increase skeletal muscle glucose uptake and glycogen synthesis but is not required for contraction-mediated increases in …
- Gitogenin suppresses lung cancer progression by inducing apoptosis and autophagy initiation through the activation of AMPK signaling
- Effects of Thiamin Restriction on Exercise-Associated Glycogen Metabolism and AMPK Activation Level in Skeletal Muscle
- Antioxidants and Oxidants in Boar Spermatozoa and Their Surrounding Environment Are Associated with AMPK Activation during Liquid Storage
- Metformin carbon dots for promoting periodontal bone regeneration via activation of ERK/AMPK pathway
- Preclinical Development of FA5, a Novel AMP-Activated Protein Kinase (AMPK) Activator as an Innovative Drug for the Management of Bowel Inflammation
- Britanin relieves ferroptosis-mediated myocardial ischaemia/reperfusion damage by upregulating GPX4 through activation of AMPK/GSK3β/Nrf2 signalling
- Bupivacaine inhibits angiogenesis through oxidative stress‐dependent inhibition of Akt/mTOR and activation of AMPK
- AMPK complex activation promotes sarcolemmal repair in dysferlinopathy
- Ligustilide attenuates ischemic stroke injury by promoting Drp1-mediated mitochondrial fission via activation of AMPK
- The Marine-Derived Macrolactone Mandelalide A Is an Indirect Activator of AMPK
- … from propolis ameliorate free fatty acids-induced non-alcoholic steatohepatitis in HepG2 cells: Involvement of enhanced AMPK activation, mTOR-NF-κBp65 …
- Activation of AMPK restored impaired autophagy and inhibited inflammation reaction by up-regulating SIRT1 in acute pancreatitis
- GPA peptide inhibits NLRP3 inflammasome activation to ameliorate colitis through AMPK pathway
- Adiponectin inhibits NLRP3 inflammasome activation in nonalcoholic steatohepatitis via AMPK-JNK/ErK1/2-NFκB/ROS signaling pathways
- Sustained AMPK activation and proline metabolism play critical roles in the survival of matrix-deprived transformed cells
- CoenzymeQ10-induced activation of AMPK-YAP-OPA1 pathway alleviates atherosclerosis by improving mitochondrial function, inhibiting oxidative stress and …
- GPR120 facilitates cholesterol efflux in macrophages through activation of AMPK signaling pathway
- … Koraiensis Extract Alleviated Metabolic Syndrome Symptoms and Stimulated UCP1‐Independent Energy Consumption via AMPK Activation in White Adipose Tissue
- Repeated intramuscular transplantations of hUCB-MSCs improves motor function and survival in the SOD1 G93A mice through activation of AMPK
- AMPK activation suppresses mTOR/S6K1 phosphorylation and induces leucine resistance in rats with sepsis
- Inhibition of VDAC1 Rescues Aβ1-42-Induced Mitochondrial Dysfunction and Ferroptosis via Activation of AMPK and Wnt/β-Catenin Pathways
- AMPK activation by 5-amino-4-imidazole carboxamide riboside-1-β-D-ribofuranoside attenuates alkali injury-induced corneal fibrosis
- Berbamine induced activation of the SIRT1/LKB1/AMPK signaling axis attenuates the development of hepatic steatosis in high-fat diet-induced NAFLD rats
- … dysfunction by cantleyoside confines inflammatory response and promotes apoptosis of human HFLS-RA cell line via AMPK/Sirt 1/NF-κB pathway activation
- Sodium acetate inhibit TGF-β1-induced activation of hepatic stellate cells by restoring AMPK or c-Jun signaling
- … against hydrogen peroxide-induced oxidative damage in human retinal pigment epithelial (RPE) cells by enhancing autophagy through activation of AMPK …
- Neoline Improves Memory Impairment and Reduces Amyloid-β Level and Tau Phosphorylation Through AMPK Activation in the Mouse Alzheimer’s Disease Model
- Attenuation of free fatty acid (FFA)-induced skeletal muscle cell insulin resistance by resveratrol is linked to activation of AMPK and inhibition of mTOR and p70 S6K
- S-petasin inhibits lipid accumulation in oleic acid-induced HepG2 cells through activation of the AMPK signaling pathway
- Impact of caudal hindbrain glycogen metabolism on A2 noradrenergic neuron AMPK activation and ventromedial hypothalamic nucleus norepinephrine activity and …
- Phosphorylation of LKB1 by PDK1 Inhibits Cell Proliferation and Organ Growth by Decreased Activation of AMPK
- Quercetin attenuates sepsis-induced acute lung injury via suppressing oxidative stress-mediated ER stress through activation of SIRT1/AMPK pathways
- … differentiation of bone marrow-derived human mesenchymal stromal cells via WnT/BMP signaling and suppresses adipocyte differentiation via AMPK activation
- Paeonia lactiflora root decreases lipid accumulation through the induction of lipolysis and thermogenesis via AMPK activation in 3T3‑L1 cells
- GLP-1-induced AMPK activation inhibits PARP-1 and promotes LXR-mediated ABCA1 expression to protect pancreatic β-cells against cholesterol-induced …
- Salsalate reverses metabolic disorders in a mouse model of non‐alcoholic fatty liver disease through AMPK activation and caspase‐6 activity inhibition
- Structure activity relationships leading to the identification of the indirect activator of AMPK, R419
- FNDC5 attenuates oxidative stress and NLRP3 inflammasome activation in vascular smooth muscle cells via activating the AMPK-SIRT1 signal pathway
- Anti-inflammatory Role of Trilobatin on Lipopolysaccharide-induced Acute Lung Injury through Activation of AMPK/GSK3β-Nrf2 Pathway.
- Inhibition of non-small cell lung cancer proliferation and survival by rosemary extract is associated with activation of ERK and AMPK
- Roflupram, a novel phosphodiesterase 4 inhibitor, inhibits lipopolysaccharide-induced neuroinflammatory responses through activation of the AMPK/Sirt1 pathway
- Lychee seed polyphenol inhibits Aβ-induced activation of NLRP3 inflammasome via the LRP1/AMPK mediated autophagy induction
- Synergetic contributions of viral VP1, VP3, and 3C to activation of the AKT-AMPK-MAPK-MTOR signaling pathway for Seneca Valley virus-induced autophagy
- Superior hypoglycemic activity of mulberry lacking monosaccharides is accompanied by better activation of the PI3K/Akt and AMPK signaling pathways
- Neurotropin inhibits lipid accumulation by maintaining mitochondrial function in hepatocytes via AMPK activation
- Soy isoflavone daidzein protects Neuro2a cells from NO stress via activation of AMPK-PGC1α pathway followed by mitochondrial enhancement
- Antioxidant activity of Oenanthe stolonifera DC extract and AMPK activation on human liver cancer cells by anticancer effects
- Dapagliflozin attenuates high glucose‐induced endothelial cell apoptosis and inflammation through AMPK/SIRT1 activation
- Beneficial Effect of Taraxacum coreanum Nakai via the Activation of LKB1-AMPK Signaling Pathway on Obesity
- Mori Ramulus suppresses hydrogen peroxide-induced oxidative damage in murine myoblast C2C12 cells through activation of AMPK
- Metformin acts to suppress β-hydroxybutyric acid-mediated inflammatory responses through activation of AMPK signaling in bovine hepatocytes
- Activation of melanocortin 1 receptor attenuates early brain injury in a rat model of subarachnoid hemorrhage viathe suppression of neuroinflammation …
- Drp1-mediated mitochondrial fission contributes to baicalein-induced apoptosis and autophagy in lung cancer via activation of AMPK signaling pathway
- Sulforaphane attenuates hexavalent chromium-induced cardiotoxicity via the activation of the Sesn2/AMPK/Nrf2 signaling pathway
- Reactive oxygen species‐mediated oxidative stress accelerates glycolysis via activation of the CaMKKβ/AMPK pathway in the yak longissimus dorsi postmortem
- Amelioration of high-insulin-induced skeletal muscle cell insulin resistance by resveratrol is linked to activation of AMPK and restoration of GLUT4 translocation
- Sulforaphane Suppresses H2O2-Induced Oxidative Stress and Apoptosis via the Activation of AMPK/NFE2L2 Signaling Pathway in Goat Mammary Epithelial Cells
- Doxorubicin cardiomyopathy is ameliorated by acacetin via Sirt1‐mediated activation of AMPK/Nrf2 signal molecules
- AMPK attenuates SHH subgroup medulloblastoma growth and metastasis by inhibiting NF-κB activation
- microRNA-519d induces autophagy and apoptosis of human hepatocellular carcinoma cells through activation of the AMPK signaling pathway via Rab10
- Mfn2 Overexpression Attenuates Cardio-Cerebrovascular Ischemia–Reperfusion Injury Through Mitochondrial Fusion and Activation of the AMPK/Sirt3 …
- … promotes osteogenic differentiation and antioxidant responses of mouse bone mesenchymal stem cells through activation of the AMPK/SIRT1 signaling pathway
- Activation of AMP-activated protein kinase (AMPK) through inhibiting interaction with prohibitins
- Inhalable nanoparticles/microparticles of an AMPK and Nrf2 activator for targeted pulmonary drug delivery as dry powder inhalers
- Liraglutide, a glucagon-like peptide-1 receptor agonist, induces ADAM10-dependent ectodomain shedding of RAGE via AMPK activation in human aortic endothelial …
- 3,4′,5-Trimethoxy-trans-stilbene Alleviates Endothelial Dysfunction in Diabetic and Obese Mice via Activation of the AMPK/SIRT1/eNOS Pathway
- Concurrent Akt, ERK1/2 and AMPK activation by obestatin inhibits apoptotic signaling cascades on nutrient-deprived PC12 cells
- TSPO ligands prevent the proliferation of vascular smooth muscle cells and attenuate neointima formation through AMPK activation
- Expression and purification of asprosin in Pichia pastoris and investigation of its increase glucose uptake activity in skeletal muscle through activation of AMPK
- … in patients with anxiety and depression myocardial infarction was up-regulated and suppressed inflammation and ferroptosis by LKB1-mediated AMPK activation
- Mitochondrial dysfunction regulates the JAK–STAT pathway via LKB1-mediated AMPK activation ER-stress-independent manner
- Epigenetic silencing of LncRNA ANRIL enhances liver fibrosis and HSC activation through activating AMPK pathway
- Fluorinated thiazolidinol drives autophagic cell death in pancreatic cancer cells via AMPK activation and perturbation of critical sentinels of oncogenic signaling
- IM156, a new AMPK activator, protects against polymicrobial sepsis
- Natural activators of AMPK signaling: potential role in the management of type-2 diabetes
- Luteolin alleviates inorganic mercury-induced kidney injury via activation of the AMPK/mTOR autophagy pathway
- Activation of AMPK suppresses S1P-induced airway smooth muscle cells proliferation and its potential mechanisms
- Imatinib protects against human beta-cell death via inhibition of mitochondrial respiration and activation of AMPK
- Inhibition of glycolysis ameliorate arthritis in adjuvant arthritis rats by inhibiting synoviocyte activation through AMPK/NF-кB pathway
- Dexmedetomidine alleviates acute lung injury by promoting Tregs differentiation via activation of AMPK/SIRT1 pathway
- Huayu Tongluo recipe attenuates renal oxidative stress and inflammation through the activation of AMPK/Nrf2 signaling pathway in streptozotocin-(STZ-) …
- Protective effect of Jiang Tang Xiao Ke Granules against skeletal muscle IR via activation of the AMPK/SIRT1/PGC-1α signaling pathway
- Functional mechanism of AMPK activation in mitochondrial regeneration of rat peritoneal macrophages mediated by uremic serum
- Activation of autophagy and suppression of apoptosis by dapagliflozin attenuates experimental inflammatory bowel disease in rats: Targeting AMPK/mTOR, HMGB1 …
- Activation of AMPK/miR-181b axis alleviates endothelial dysfunction and vascular inflammation in diabetic mice
- Inhibition of HMGB1 reduced high glucose-induced BMSCs apoptosis via activation of AMPK and regulation of mitochondrial functions
- Hepatic proteomic changes and Sirt1/AMPK signaling activation by oxymatrine treatment in rats with non-alcoholic steatosis
- Transient Ca2+ entry by plasmalogen-mediated activation of receptor potential cation channel promotes AMPK activity
- Ferritinophagy is involved in Bisphenol A-induced ferroptosis of renal tubular epithelial cells through the activation of the AMPK-mTOR-ULK1 pathway
- β-Aminoisobutyric acid, L-BAIBA, protects PC12 cells from hydrogen peroxide-induced oxidative stress and apoptosis via activation of the AMPK and PI3K/Akt …
- Human prion protein-mediated calcineurin activation induces neuron cell death via AMPK and autophagy pathway
- Cx32 promotes autophagy and produces resistance to SN‑induced apoptosis via activation of AMPK signalling in cervical cancer
- Activation of AMPK/p38/Nrf2 is involved in resveratrol alleviating myocardial ischemia-reperfusion injury in diabetic rats as an endogenous antioxidant stress …
- Neuroprotective effects of resveratrol against oxygen glucose deprivation induced mitochondrial dysfunction by activation of AMPK in SH-SY5Y cells with 3D gelatin …
- Genistein accelerates glucose catabolism via activation the GPER-mediated cAMP/PKA-AMPK signaling pathway in broiler chickens
- Metformin inhibits ROS production by human M2 macrophages via the activation of AMPK
- Activation of autophagic flux via LKB1/AMPK/mTOR axis against xenoestrogen Bisphenol-A exposure in primary rat hepatocytes
- Sulforaphane induces lipophagy through the activation of AMPK-mTOR-ULK1 pathway signaling in adipocytes
- Novel indolic AMPK modulators induce vasodilatation through activation of the AMPK–eNOS–NO pathway
- Elucidating the Activation Mechanism of AMPK by Direct Pan-Activator PF-739
- Indirubin-3′-oxime (IDR3O) inhibits proliferation of osteosarcoma cells in vitro and tumor growth in vivo through AMPK-activation and PGC-1α/TFAM up-regulation
- Solasonine suppresses the proliferation of acute monocytic leukemia through the activation of the AMPK/FOXO3A Axis
- AdipoRon, an adiponectin receptor agonist, protects contrast-induced nephropathy by suppressing oxidative stress and inflammation via activation of the AMPK …
- Discovery and evaluation of biphenyl derivatives of 2‐iminobenzimidazoles as prototype dual PTP1B inhibitors and AMPK activators with in vivo antidiabetic activity
- Activation of AMPK/Sirt3 pathway by phloretin reduces mitochondrial ROS in vascular endothelium by increasing the activity of MnSOD via deacetylation
- Aspiletrein A Induces Apoptosis Cell Death via Increasing Reactive Oxygen Species Generation and AMPK Activation in Non-Small-Cell Lung Cancer Cells
- TRIM22 inhibits osteosarcoma progression through destabilizing NRF2 and thus activation of ROS/AMPK/mTOR/autophagy signaling
- Penicilliumin B protects against cisplatin-induced renal tubular cell apoptosis through activation of AMPK-induced autophagy and mitochondrial biogenesis
- Anti-adipogenic effect of the flavonoids through the activation of AMPK in palmitate (PA)-treated HepG2 cells
- Extracellular superoxide dismutase prevents skin aging by promoting collagen production through the activation of AMPK and Nrf2/HO-1 cascades
- Vanadium-protein complex inhibits human adipocyte differentiation through the activation of β-catenin and LKB1/AMPK signaling pathway
- Pterostilbene inhibits FcεRI signaling through activation of the LKB1/AMPK pathway in allergic response
- Beneficial and sexually dimorphic response to combined HDAC inhibitor valproate and AMPK/SIRT1 pathway activator resveratrol in the treatment of ALS …
- Selective Inhibition of Organic Cation Transporter 1 by Benzoylpaeoniflorin Attenuates Hepatic Lipid Accumulation through AMPK Activation
- Dexmedetomidine Enhances Autophagy via α2-AR/AMPK/mTOR Pathway to Inhibit the Activation of NLRP3 Inflammasome and Subsequently Alleviates …
- Ipragliflozin, an SGLT2 inhibitor, ameliorates high-fat diet-induced metabolic changes by upregulating energy expenditure through activation of the AMPK …
- Calycosin-7-O-β-D-glucoside attenuates palmitate-induced lipid accumulation in hepatocytes through AMPK activation
- … Attenuates Vascular Calcification in Mice with Chronic Kidney Disease by Regulating the NFR2/HO-1 Anti-Inflammatory Pathway through AMPK Activation
- GLP-1R activation ameliorated novel-object recognition memory dysfunction via regulating hippocampal AMPK/NF-κB pathway in neuropathic pain mice
- Intracellular Calcium Overload and Activation of CaMKK/AMPK Signaling Are Related to the Acceleration of Muscle Glycolysis of Broiler Chickens Subjected to Acute …
- The activation of AMPK/NRF2 pathway in lung epithelial cells is involved in the protective effects of kinsenoside on lipopolysaccharide-induced acute lung …
- Herba houttuyniae Extract Benefits Hyperlipidemic Mice via Activation of the AMPK/PGC-1α/Nrf2 Cascade
- … sterol ester of α-linolenic acid improved non-alcoholic fatty liver disease by attenuating endoplasmic reticulum stress-triggered apoptosis via activation of the AMPK
- … acid promotes the formation of autophagosomes in MCF-7 breast cancer cells through oxidative stress-induced growth inhibitor 1 mediated activation of AMPK/mTOR …
- Activation of AdipoR1 with rCTRP9 preserves BBB integrity through the APPL1/AMPK/Nrf2 signaling pathway in ICH mice
- Gryllus bimaculatus extract ameliorates high-fat diet-induced hyperglycemia and hyperlipidemia by inhibiting hepatic lipogenesis through AMPK activation
- Gypenoside A protects ischemia/reperfusion injuries by suppressing miR‐143‐3p level via the activation of AMPK/Foxo1 pathway
- Mogroside IIIE alleviates high glucose-induced inflammation, oxidative stress and apoptosis of podocytes by the activation of AMPK/SIRT1 signaling pathway
- Activation of AMPK/mTOR-driven autophagy and inhibition of NLRP3 inflammasome by saxagliptin ameliorate ethanol-induced gastric mucosal damage
- Iron chelation inhibits mTORC1 signaling involving activation of AMPK and REDD1/Bnip3 pathways
- Ginkgolide B‑induced AMPK pathway activation protects astrocytes by regulating endoplasmic reticulum stress, oxidative stress and energy metabolism …
- … A, a new biflavanone, and a chalcone glucoside from the flower heads of Coreopsis lanceolata and their aldose reductase inhibitory activity and AMPK activation
- Icariin treatment protects against gentamicin-induced ototoxicity via activation of the AMPK-SIRT3 pathway
- Activation of AMPK entails the protective effect of royal jelly against high-fat-diet-induced hyperglycemia, hyperlipidemia, and non-alcoholic fatty liver disease in rats
- Regulatory mechanism of fermented wheat germ on lipid metabolism in hyperlipidemia rats via activation of AMPK pathway
- Baicalin promotes the activation of brown and white adipose tissue through AMPK/PGC1α pathway
- AMPK‐mTOR‐ULK1 axis activation‐dependent autophagy promotes hydroxycamptothecin‐induced apoptosis in human bladder cancer cells
- Activation of autophagy by sitagliptin attenuates cadmium-induced testicular impairment in rats: Targeting AMPK/mTOR and Nrf2/HO-1 pathways
- Thymol alleviates LPS-induced liver inflammation and apoptosis by inhibiting NLRP3 inflammasome activation and the AMPK-mTOR-autophagy pathway
- Fruits of Rosa laevigata and its bio-active principal sitostenone facilitate glucose uptake and insulin sensitivity in hepatic cells via AMPK/PPAR-γ activation
- Cadmium exposure induces rat proximal tubular cells injury via p62-dependent Nrf2 nucleus translocation mediated activation of AMPK/AKT/mTOR pathway
- Diet control to achieve euglycaemia induces tau hyperphosphorylation via AMPK activation in the hippocampus of diabetic rats
- Resveratrol alleviates high glucose-induced oxidative stress and apoptosis in rat cardiac microvascular endothelial cell through AMPK/Sirt1 activation
- Metformin attenuates fibroblast activation during pulmonary fibrosis by targeting S100A4 via AMPK-STAT3 axis
- Discovery of seneciobipyrrolidine derivatives for the amelioration of glucose homeostasis disorders through 4E-BP1/Akt/AMPK signaling activation
- Albendazole-induced autophagy blockade contributes to elevated apoptosis in cholangiocarcinoma cells through ampk/mtor activation
- Curcumin represses mTORC1 signaling in Caco-2 cells by a two-sided mechanism involving the loss of IRS-1 and activation of AMPK
- Anti-diabetic activity of extract from Morus nigra L. twigs through activation of AMPK/PKC pathway in mice
- Cordycepin Attenuates Testosterone-Induced Benign Prostatic Hyperplasia in Rats via Modulation of AMPK and AKT Activation
- … -induced acute kidney injury through attenuation of inflammation, oxidative stress and apoptotic effects and activation of the CaMKK–AMPK–sirt1-associated signaling …
- … Protein 9 Inhibits High Glucose–Induced Oxidative Stress and Apoptosis in Retinal Pigment Epithelial Cells Through the Activation of AMPK/Nrf2 Signaling Pathway
- Myeloid deletion and therapeutic activation of AMPK do not alter atherosclerosis in male or female mice
- Lycorine improves peripheral nerve function by promoting Schwann cell autophagy via AMPK pathway activation and MMP9 downregulation in diabetic peripheral …
- … reveals that camel and goat milk improve glucose homeostasis in HDF/STZ-induced diabetic rats through activation of hepatic AMPK and GSK3-GYS axis
- Activation of AMPK-PGC-1α pathway ameliorates peritoneal dialysis related peritoneal fibrosis in mice by enhancing mitochondrial biogenesis
- Theaflavin inhibits African swine fever virus replication by disrupting lipid metabolism through activation of the AMPK signaling pathway in virto
- Methyl eugenol protects the kidney from oxidative damage in mice by blocking the Nrf2 nuclear export signal through activation of the AMPK/GSK3β axis
- Taurine prevents high‐fat diet‐induced‐hepatic steatosis in rats by direct inhibition of hepatic sterol regulatory element‐binding proteins and activation of AMPK
- Ym155 localizes to the mitochondria leading to mitochondria dysfunction and activation of AMPK that inhibits BMP signaling in lung cancer cells
- Sinensol-C Isolated from Spiranthes sinensis Inhibits Adipogenesis in 3T3-L1 Cells through the Regulation of Adipogenic Transcription Factors and AMPK Activation
- … glycoside mediates hepatic glucose homeostasis through inhibition of gluconeogenesis and activation of glycogenesis via regulating the AMPK/FoxO1/AKT/GSK3β …
- Activation of AMPK sensitizes medulloblastoma to Vismodegib and overcomes Vismodegib‐resistance
- Targeted Activation of HNF4α by AMPK Inhibits Apoptosis and Ameliorates Neurological Injury Caused by Cardiac Arrest in Rats
- Saikosaponin A inhibits the activation of pancreatic stellate cells by suppressing autophagy and the NLRP3 inflammasome via the AMPK/mTOR pathway
- Pyrazolone derivative C29 protects against HFD-induced obesity in mice via activation of AMPK in adipose tissue
- Evaluation of AMPK activity in mice by measuring activator-induced glucose uptake
- AMPK activation increases postoperative cognitive impairment in intermittent hypoxia rats via direct activating PAK2
- … of Portulaca Oleracea L., HM-chromanone, improves palmitate-induced insulin resistance by inhibiting mTOR/S6K1 through activation of the AMPK pathway in L6 …
- Vitexin attenuates autoimmune hepatitis in mouse induced by syngeneic liver cytosolic proteins via activation of AMPK/AKT/GSK-3β/Nrf2 pathway
- Protein kinase CK2 activates Nrf2 via autophagic degradation of Keap1 and activation of AMPK in human cancer cells
- Renal denervation improves vascular endothelial dysfunction by inducing autophagy via AMPK/mTOR signaling activation in a rat model of type 2 diabetes mellitus …
- Inhibiting lysosomal aldolase: a magic bullet for AMPK activation in treating metabolic disease?
- mTORC1 silencing during intestinal epithelial Caco-2 cell differentiation is mediated by the activation of the AMPK/TSC2 pathway
- … seed polyphenol protects the blood–brain barrier through inhibiting Aβ (25–35)‐induced NLRP3 inflammasome activation via the AMPK/mTOR/ULK1‐mediated …
- … ischemia/reperfusion injury-induced cardiomyocytes apoptosis by alleviating endoplasmic reticulum stress via activation of AMPK-PAK2 signaling in H9C2 …
- … sensitivity and mitochondrial respiration in skeletal muscle of type-2 diabetic mice through insulin signaling pathway and AMPK/SIRT1/PGC-1α/PPAR-γ activation
- AMPK promotes Arf6 activation in a kinase-independent manner upon glucose starvation
- Asteltoxin inhibits extracellular vesicle production through AMPK/mTOR-mediated activation of lysosome function
- Synergistic activation of AMPK by AdipoR1/2 agonist and inhibitor of EDPs–EBP interaction recover NAFLD through enhancing mitochondrial function in mice
- The AMPK pathway triggers autophagy during CSF1-induced microglial activation and may be implicated in inducing neuropathic pain
- Secretory clusterin promotes oral cancer cell survival via inhibiting apoptosis by activation of autophagy in AMPK/mTOR/ULK1 dependent pathway
- Activation of AMPK by telmisartan decreases basal and PDGF-stimulated VSMC proliferation via inhibiting the mTOR/p70S6K signaling axis
- Biochanin A induces a brown‐fat phenotype via improvement of mitochondrial biogenesis and activation of AMPK signaling in murine C3H10T1/2 mesenchymal stem …
- Protective effects of sulforaphane on type 2 diabetes-induced cardiomyopathy via AMPK-mediated activation of lipid metabolic pathways and NRF2 function
- Triiodothyronine potentiates BMP9-induced osteogenesis in mesenchymal stem cells through the activation of AMPK/p38 signaling
- … , 2-phenyl-1, 4-benzodioxane-6-dithioacetals and 2-phenylbenzofuran-5-dithioacetals: Synthesis and primary evaluation as potential antidiabetic AMPK-activators
- Alpha-lipoic acid attenuates silica-induced pulmonary fibrosis by improving mitochondrial function via AMPK/PGC1α pathway activation in C57BL/6J mice
- Osthole: A potential AMPK agonist that inhibits NLRP3 inflammasome activation by regulating mitochondrial homeostasis for combating rheumatoid arthritis
- VRK-1 extends life span by activation of AMPK via phosphorylation
- Imidazo[1,2‐a]pyridine Derivatives as AMPK Activators: Synthesis, Structure–Activity Relationships, and Regulation of Reactive Oxygen Species in Renal Fibroblasts
- … neointimal hyperplasia and prevents vascular smooth muscle cell dedifferentiation, proliferation, and migration via activation of AMPK/PPAR-γ signaling
- … aggravation and lung injury by modulating AMPK/PI3K/Akt/p38-NF-κB and TGF-β/Smad/Bcl2/caspase/LC3 cascade and macrophages activation in murine model of …
- Atractyloside Protect Mice Against Liver Steatosis by Activation of Autophagy via ANT-AMPK-mTORC1 Signaling Pathway
- … protects human skin keratinocytes against ultraviolet B-induced photodamage via autophagy activation by regulating the AMPK-mTOR signaling pathway
- Activation of Nrf2 by Lithospermic Acid Ameliorates Myocardial Ischemia and Reperfusion Injury by Promoting Phosphorylation of AMP-Activated Protein Kinase α …
- The protective effects of corn oligopeptides on acute alcoholic liver disease by inhibiting the activation of kupffer cells NF-κB/AMPK signal pathway
- … Spared Nerve Injury-Induced Neuropathic Pain in Mice by Inhibiting Microglia Activation and Neuronal Oxidative Damage in the Spinal Cord via the AMPK Pathway
- Naringin promotes fat browning mediated by UCP1 activation via the AMPK signaling pathway in 3T3-L1 adipocytes
- RETRACTED ARTICLE: MicroRNA-206 inhibition and activation of the AMPK/Nampt signalling pathway enhance sevoflurane post-conditioning-induced amelioration …
- Mogroside V alleviates lipopolysaccharide-induced neuroinflammation via inhibition of TLR4-MyD88 and activation of AKT/AMPK-Nrf2 signaling pathway
- Activation of AMPK‐dependent autophagy in the nucleus accumbens opposes cocaine‐induced behaviors of mice
- … effect of sulforaphane against oxidative stress in granulosa cells of patients with polycystic ovary syndrome (PCOS) through activation of AMPK/AKT/NRF2 signaling …
- Exercise improves homeostasis of the intestinal epithelium by activation of APJ‐AMPK signaling
- Soyasapogenol C from Fermented Soybean (Glycine Max) Acting as a Novel AMPK/PPARα Dual Activator Ameliorates Hepatic Steatosis: A Novel SANDA …
- TRPV1 activation mitigates hypoxic injury in mouse cardiomyocytes by inducing autophagy through the AMPK signaling pathway
- Prostaglandin EP3 receptor activation is antinociceptive in sensory neurons via PI3Kγ, AMPK and GRK2
- Chrysanthemum morifolium Flower Extract Inhibits Adipogenesis of 3T3-L1 Cells via AMPK/SIRT1 Pathway Activation
- Aerobic exercise ameliorates myocardial ischemia/reperfusion injury and thrombosis of diabetic rats via activation of AMPK/Sirt1/PGC-1α pathway.
- Sulforaphane prevents type 2 diabetes-induced nephropathy via AMPK-mediated activation of lipid metabolic pathways and Nrf2 antioxidative function
- Dehydroepiandrosterone protects against hepatic glycolipid metabolic disorder and insulin resistance induced by high fat via activation of AMPK-PGC-1α-NRF-1 and …
- Comprehensive Comparisons between Grafted Kynam Agarwood and Normal Agarwood on Traits, Composition, and In Vitro Activation of AMPK
- n-Butylidenephthalide inhibits the phenotypic switch of VSMCs through activation of AMPK and prevents stenosis in an arteriovenous fistula rat model
- Effect of curcumin on IL-17A mediated pulmonary AMPK kinase/cyclooxygenase-2 expressions via activation of NFκB in bleomycin-induced acute lung injury in vivo
- Activation of transient receptor potential vanilloid 4 protects articular cartilage against inflammatory responses via CaMKK/AMPK/NF-κB signaling pathway
- Teaghrelin Protects SH-SY5Y Cells against MPP+-Induced Neurotoxicity through Activation of AMPK/SIRT1/PGC-1α and ERK1/2 Pathways
- Dexmedetomidine protects against septic liver injury by enhancing autophagy through activation of the AMPK/SIRT1 signaling pathway
- Activation of AMPK inhibits Galectin-3-induced pulmonary artery smooth muscle cells proliferation by upregulating hippo signaling effector YAP
- Inhibition Effect of Adipogenesis and Lipogenesis via Activation of AMPK in Preadipocytes Treated with Canavalia gladiata Extract
- Apelin-13 protects dopaminergic neurons against rotenone—induced neurotoxicity through the AMPK/mTOR/ULK-1 mediated autophagy activation
- Lactobacillus plantarum postbiotics trigger AMPK‐dependent autophagy to suppress Salmonella intracellular infection and NLRP3 inflammasome activation
- Kiss1 Inhibits the Proliferation of Nasopharyngeal Carcinoma Cells Via Activation of the LKB1/AMPK Pathway
- (−)-Hydroxycitric acid regulates energy metabolism by activation of AMPK-PGC1α-NRF1 signal pathway in primary chicken hepatocytes
- Hepatic AMPK signaling activation in response to dynamic REDOX balance is a biomarker of exercise to improve blood glucose control.
- Vitamin D3 potentiates the nephroprotective effects of metformin in a rat model of metabolic syndrome: Role of AMPK/SIRT1 activation and DPP-4 inhibition
- … ) Inhibits Proliferation, Suppresses Cell Migration and Invasion and Decreases Tumor Growth of Osteosarcoma: Role of PGC-1α/TFAM and AMPK-Activation
- … cadmium chloride-induced memory loss and hippocampal apoptosis by increased intracellular glutathione stores and activation of PTEN/AMPK induced inhibition of …
- Ampk activation by glycogen expenditure primes the exit of naive pluripotency
- Coix lacryma-jobi seed oil reduces fat accumulation in nonalcoholic fatty liver disease by inhibiting the activation of the p-AMPK/SePP1/ApoER2 pathway
- Wheat bran oil concentrate induced AMPK activation, insulin and lipid homeostasis alleviates adipokines and cytokine in high fat fed C57BL6 mice
- … protects against oleic acid-triggered mitochondrial dysfunction to relieve oxidative stress and inflammation via activation of the AMPK-Nrf2 axis by targeting GPR30 in …
- Irisin Regulates Hepatic Glucose Metabolism via AMPK and PI3K/Akt Activation
- UBE3A deficiency-induced autophagy is associated with activation of AMPK-ULK1 and p53 pathways
- CD73 aggravates alcohol-related liver fibrosis by promoting autophagy mediated activation of hepatic stellate cells through AMPK/AKT/mTOR signaling …
- Activation of AMPK/proteasome/MLCK degradation signaling axis by telmisartan inhibits VSMC contractility and vessel contraction
- Neoagarotetraose extends the lifespan of Caenorhabditis elegans through AMPK mediated signaling pathways and activation of autophagy
- Prior AICAR induces elevated glucose uptake concomitant with greater γ3-AMPK activation and reduced membrane cholesterol in skeletal muscle from 26-month-old …
- Metformin mitigates renal dysfunction in obese insulin-resistant rats via activation of the AMPK/PPARα pathway
- Quinacrine attenuates diet-induced obesity by inhibiting adipogenesis via activation of AMPK signaling
- Activation of AMPK signalling by Metformin: Implication an important molecular mechanism for protecting against mice silicosis via inhibited endothelial cell-to …
- Lipid Extract From a Vegetable (Sonchus Oleraceus) Attenuates Adipogenesis and High Fat Diet-Induced Obesity Associated With AMPK Activation
- Role of SESTRIN2/AMPK/ULK1 pathway activation and lysosomes dysfunction in NaAsO2-induced liver injury under oxidative stress
- AMPK Activation Enhances Neutrophil’s Fungicidal Activity in Vitro and Improves the Clinical Outcome of Fusarium solani Keratitis in Vivo
- Ameliorative Effects of Lactobacillus plantarum HAC01 Lysate on 3T3-L1 Adipocyte Differentiation via AMPK Activation and MAPK Inhibition
- Pre-extinction activation of hippocampal AMPK prevents fear renewal in mice
- Xuezhikang alleviates lipid accumulation via AMPK activation in hepatocellular steatosis model
- Adiponectin protects HL-1 cardiomyocytes against rotenone-induced cytotoxicity through AMPK activation
- Seabuckthorn Reverses High-Fat-Diet-Induced Obesity and Enhances Fat Browning via Activation of AMPK/SIRT1 Pathway
- Exendin-4 increases scavenger receptor class BI expression via activation of AMPK/FoxO1 in human vascular endothelial cells
- Blueberry Stem Extract Prevents Lacrimal Hyposecretion in Non-obese Diabetic Mice via Activation of AMPK
- The AMPK activator A-769662 inhibits human TASK3 potassium channels in an AMPK-independent manner
- Walnut-Derived Peptides Promote Autophagy via the Activation of AMPK/mTOR/ULK1 Pathway to Ameliorate Hyperglycemia in Type 2 Diabetic Mice
- A long-term high-fat diet influences brain damage and is linked to the activation of HIF-1α/AMPK/mTOR/p70S6K signalling
- Combination of mTOR inhibitor PP242 and AMPK activator metformin exerts enhanced inhibitory effects on colorectal carcinoma cells in vitro by blocking multiple …
- … contractility modulation ameliorates myocardial metabolic remodeling in a rabbit model of chronic heart failure through activation of AMPK and PPAR-α …
- The natural compound rutaecarpine promotes white adipocyte browning through activation of the AMPK-PRDM16 axis
- … alleviated doxorubicin induced JNK activation and Cx43 phosphorylation associated cardiotoxicity via activation of AMPK-SHP2 signaling pathway
- Validation of the antidiabetic potential of isolated and nanoemulsified endophytic fungal metabolite 2, 4, 6-triphenylaniline through AMPK activation pathway
- … improves mitochondrial function in oxygen-glucose deprivation and reperfusion-induced cardiomyocyte injury by activation of the AMPK/PGC-1 axis
- Canagliflozin facilitates reverse cholesterol transport through activation of AMPK/ABC transporter pathway
- Role of exercise on alleviating pressure overload-induced left ventricular dysfunction and remodeling via AMPK-dependent autophagy activation
- Prospective evaluation of effect of metformin on activation of amp-activated protein kinase (ampk) and disease control in a sub-group analysis of patients with …
- Hepatic AMPK activation in response to dynamic REDOX balance is a biomarker of exercise to improve blood glucose control
- Salidroside promotes osteoblast proliferation and differentiation via the activation of AMPK to inhibit bone resorption of knee osteoarthritis mice
- Salvianolic Acid B Alleviates Myocardial Ischemia Injury by Suppressing NLRP3 Inflammasome Activation via SIRT1-AMPK-PGC-1α Signaling Pathway
- Roflumilast ameliorates ovariectomy-induced depressive-like behavior in rats via activation of AMPK/mTOR/ULK1-dependent autophagy pathway
- Activation of Ca2+‐AMPK‐mediated autophagy by ginsenoside Rg3 attenuates cellular senescence in human dermal fibroblasts
- … tanshinone IIA silate alleviates high glucose induced barrier impairment of human retinal pigment epithelium through the reduction of NF-κB activation via the AMPK …
- The activation of Wnt signaling facilitates autophagy by modulating GSK-3β-AMPK axis in atherosclerosis
- Loliolide from Artemisia princeps Suppresses Adipogenesis in Human Bone Marrow-Derived Mesenchymal Stromal Cells via Activation of AMPK and Wnt/β-catenin …
- Crataegus aronia prevents high‐fat diet‐induced hepatic steatosis in rats by activating AMPK‐induced suppression of SREBP1 and activation of PPARα
- FFAR2 antagonizes TLR2-and TLR3-induced lung cancer progression via the inhibition of AMPK-TAK1 signaling axis for the activation of NF-κB
- AMPK mediates early activation of the unfolded protein response through a positive feedback loop in palmitate-treated muscle cells
- Magnolol improves Alzheimer’s disease-like pathologies and cognitive decline by promoting autophagy through activation of the AMPK/mTOR/ULK1 pathway
- Apocarotenoids from Equisetum debile Roxb. ex Vaucher regulate the lipid metabolism via the activation of the AMPK/ACC/SREBP-1c signaling pathway
- Calycosin alleviates injury in airway epithelial cells caused by PM 2.5 exposure via activation of AMPK signalling
- Survival Pathways of HIF-Deficient Tumour Cells: TCA Inhibition, Peroxisomal Fatty Acid Oxidation Activation and an AMPK-PGC-1α Hypoxia Sensor
- … partner interacting leucine zipper protein (SMILE) ameliorates autoimmune arthritis via AMPK signaling pathway and the regulation of B cell activation
- … -3-O-rutinoside from Moringa oleifera Downregulates Adipogenesis and Lipid Accumulation and Improves Glucose Uptake by Activation of AMPK/Glut-4 in …
- 6-Phosphogluconate dehydrogenase inhibition arrests growth and induces apoptosis in gastric cancer via AMPK activation and oxidative stress
- Apelin-13 induces mitophagy in bone marrow mesenchymal stem cells to suppress intracellular oxidative stress and ameliorate osteoporosis by activation of AMPK …
- Targeting Breast Cancer and Their Stem Cell Population through AMPK Activation: Novel Insights. Cells 2022, 11, 576
- Integrated single-cell RNA-seq analysis revealed podocyte injury through activation of the BMP7/AMPK/mTOR mediated autophagy pathway
- Blockage of fibronectin 1 ameliorates myocardial ischemia/reperfusion injury in association with activation of AMP-LKB1-AMPK signaling pathway
- Fructus Zanthoxyli extract improves glycolipid metabolism disorder of type 2 diabetes mellitus via activation of AMPK/PI3K/Akt pathway: Network pharmacology and …
- Osteosarcoma Cell Growth Inhibition by Isoxanthanol-Nanoparticles through Histone H3 Lysine 27 Trimethylation Downregulation and AMPK Activation
- PRL stimulates mitotic errors by suppressing kinetochore-localized activation of AMPK during mitosis
- AMPK Activation Improves Recovery from Pneumonia-Induced Lung Injury via Reduction of ER-Stress and Apoptosis in Alveolar Epithelial Cells
- … Mellitus by Activating Monophosphate-Activated Protein Kinase (AMPK)/Sirtuin 1 (SIRT1) Axis and Inhibiting Nuclear Factor-kappa B (NF-κB) Activation
- … factor‐related protein 9 protects cultured chondrocytes from IL‐1β‐induced inflammatory injury by inhibiting NLRP3 inflammasome activation via the AdipoR1/AMPK …
- Dehydroepiandrosterone alleviates oleic acid-induced lipid metabolism disorders through activation of AMPK-mTOR signal pathway in primary chicken …
- Florofangchinoline inhibits proliferation of osteosarcoma cells via targeting of histone H3 lysine 27 trimethylation and AMPK activation
- Increased effects of 2, 5-dimethylcelecoxib on sensitivity of hepatocellular carcinoma cells to sorafenib via CYP3A5 expression and activation of AMPK
- Identification of flavone C-glycosides from Glycyrrhiza uralensis seeds and their effects on AMPK activation
- Cytosolic 5′-nucleotidase II silencing in lung tumor cells regulates metabolism through activation of the p53/AMPK signaling pathway
- Effects of short-term fasting and pharmacological activation of AMPK on metabolism of rat adipocytes
- EGR‑1 plays a protective role in AMPK inhibitor compound C‑induced apoptosis through ROS‑induced ERK activation in skin cancer cells
- Alcohol Aggravates Acute Pancreatitis by Impairing Autophagic Flux Through Activation of AMPK Signaling Pathway
- Purple corn extract (PCE) alleviates cigarette smoke (CS)-induced DNA damage in rodent blood cells by activation of AMPK/Foxo3a/MnSOD pathway
- β-Boswellic Acid Suppresses Breast Precancerous Lesions via GLUT1 Targeting-Mediated Glycolysis Inhibition and AMPK Pathway Activation
- Activation of the AMPK-ULK1 pathway mediated protective autophagy by sevoflurane anesthesia restrains LPS-induced acute lung injury (ALI)
- Limonin, an AMPK Activator, Inhibits Hepatic Lipid Accumulation in High Fat Diet Fed Mice
- Enhanced Oxygen Utilization Efficiency With Concomitant Activation of AMPK-TBC1D1 Signaling Nexus in Cyclophilin-D Conditional Knockout Mice
- RETRACTED: Zhou et al. Pyrvinium Treatment Confers Hepatic Metabolic Benefits via β-Catenin Downregulation and AMPK Activation. Pharmaceutics 2021, 13 …
- Highlighting the Protective or Degenerative Role of AMPK Activators in Dementia Experimental Models
- Vascular Biology and Microcirculation: AMPK activation in pregnant human myometrial arteries from high-altitude and intrauterine growth-restricted …
- Novel Dual mTOR Inhibitor/AMPK Activator Mitigates Doxorubicin Cardiotoxicity and Potentiates Its Chemotherapeutic Efficacy Against Triple Negative Breast Cancer
- Abnormal in LMNA triggers a shift in intracellular metabolic homeostasis via AMPK activation
- Activation of AMPK pathway compromises Rab11 downregulation-mediated inhibition of Schwann cell proliferation in a Glut1 and Glut3-dependent manner
- The Role of AMPK Signaling in Brown Adipose Tissue Activation. Cells 2021, 10, 1122
- Cordycepin inhibits the proliferation and migration of human gastric cancer cells by suppressing lipid metabolism via AMPK and MAPK activation
- … inhibits VEGF-induced HUVECs proliferation, migration and invasion through AMPK/mTOR pathway-dependent autophagy activation and cell cycle arrest
- … cell-derived factor-1 (SDF-1) suppresses the NLRP3 inflammasome and inhibits pyroptosis in synoviocytes from osteoarthritic joints via activation of the AMPK …
- Exendin-4 protects against myocardial ischemia-reperfusion injury by upregulation of SIRT1 and SIRT3 and activation of AMPK
- Petatewalide B alleviates oxygen‑glucose deprivation/reoxygenation‑induced neuronal injury via activation of the AMPK/Nrf2 signaling pathway
- … protects rat hippocampal neurons after restoration of spontaneous circulation following cardiac arrest via activation of the AMPK/mTOR signaling pathway
- … –Arginine–Tryptophan) Improves Glucose Tolerance in High Fat Diet Fed C57BL/6 Mice via Activation of Insulin Signaling and AMPK Pathways in Skeletal …
- ZG02 Improved hepatic glucose metabolism and insulin sensitivity via activation of AMPK/Sirt1 signaling pathways in a high-fat diet/streptozotocin-induced Type 2 …
- Energy Provisioning and Inflammasome Activation: The Pivotal Role of AMPK in Sterile Inflammation and Associated Metabolic Disorders
- AMPK Activator Metformin Alters Oligodendrocyte Energetics to Promote Cellular Differentiation and Accelerate Remyelination in the Cuprizone Model of Myelin …
- Cyanidin-3-O-glucoside attenuates high glucose–induced podocyte dysfunction by inhibiting apoptosis and promoting autophagy via activation of SIRT1/AMPK …
- Carnosic acid attenuates inflammation, oxidative stress and mitochondrial dysfunction in neurons via activation of AMPK/SIRT1 pathway
- Midkine noncanonically suppresses AMPK activation through disrupting the LKB1-STRAD-Mo25 complex
- I15 Reduction of glutamate dehydrogenase induces autophagy via tor inhibition and AMPK activation in a drosophila model for Huntington’s disease
- Restriction of intracellular Salmonella typhimurium growth by the small-molecule autophagy inducer A77 1726 through the activation of the AMPK-ULK1 axis
- Dietary Activation of AMP-Activated Protein Kinase (AMPK) to Treat Insulin Resistance
- Antihyperalgesia effect of AMP-activated protein kinase (AMPK) activators in a mouse model of postoperative pain
- Role for toll-like receptor 9 in muscle AMPK activation
- … lipopolysaccharide‑induced BEAS‑2B cell injury through inhibition of endoplasmic reticulum stress via activation of the AMPK/SIRT1 signaling pathway
- Natural Phenolic Compounds Targeting The AMPK Activation For Metabolic Health
- Bariatric surgery improves autophagy and leukocyte-endothelial cell interactions through AMPK activation at one year follow-up
- OR2H2 Activation Suppresses Cellular Senescence and Aging by Activating AMPK and Inducing Senolysis in VK2/E6E7 Cells
- Dexmedetomidine associated lung cancer proliferation and tumor growth is prevented by β-caryophyllene: Role of AMPK activation and PGC-1α/TFAM over …
- Metformin Inhibits STAT3 and MAPK Signaling through AMPK Activation in CSF3RT618I Cells
- The Effects of NT-1044, a Novel AMPK Activator, on Endometrial Cancer Cell Proliferation, Apoptosis, Cell Stress and In Vivo Tumor Growth
- Oxyresveratrol and its synthetic derivatives on the stimulation of glucose uptake in skeletal muscle cells and the activation of AMPK.
- Small-molecule 7, 8-dihydroxyflavone counteracts compensated and decompensated cardiac hypertrophy via AMPK activation
- Salidroside inhibits insulin resistance and hepatic steatosis by downregulating miR-21 and subsequent activation of AMPK and upregulation of PPARα in the liver and …
- Compound 13 Promotes Epidermal Healing in Mouse Fetuses via Activation of AMPK
- Treatment Of Human Pulmonary Microvascular Endothelial Cells with NO leads to Increased PDE3A Protein Expression and AMPK Activation
- Chlorogenic acid modulates glucose and lipid metabolisms via AMPK activation in HepG2 cells and shows its anti-hyperglycemic effect on streptozocin-induced …
- … : Isovitexin-Mediated Regulation of Microglial Polarization in Lipopolysaccharide-Induced Neuroinflammation via Activation of the CaMKKβ/AMPK-PGC-1α Signaling …
- … Induced Reactive Oxygen Species–Mediated Apoptosis in Macrophages through AIF Nuclear Translocation and AMPK/Nrf-2/HO-1 Pathway Activation
- AMPK activation protects against prostate cancer by inducing a catabolic cellular state
- Anti-diabetic effects of glucomanno-oligosaccharides via AMPK activation in C2C12 myotubes
- Linagliptin improves high glucose-induced glomerular endothelial hyper-permeability through AMPK activation and RhoA/ROCK suppression
- … 1 blocker candesartan improves morphine tolerance by reducing morphine‑induced inflammatory response and cellular activation of BV2 cells via the PPARγ/AMPK …
- Pyrvinium Treatment Confers Hepatic Metabolic Benefits via β-catenin Downregulation and AMPK Activation. Pharmaceutics 2021, 13, 330
- XAF1 directs glioma response to temozolomide through apoptotic transition of autophagy by activation of ATM–AMPK signaling
- [6]-Gingerol Suppresses Oral Cancer Cell Growth by Inducing the Activation of AMPK and Suppressing the AKT/mTOR Signaling Pathway
- MicroRNA-506-3p targets SIRT1 and suppresses AMPK pathway activation to promote hepatic steatosis Corrigendum in/10.3892/etm. 2022.11390
- Myeloid deletion and therapeutic activation of AMP-activated protein kinase (AMPK) do not alter atherosclerosis in male or female mice
- Mechanism of autophagy induced by activation of the AMPK/ERK/mTOR signaling pathway after TRIM22-mediated DENV-2 infection of HUVECs
- Protective effects of a new AMPK activator, LNP599, in a marmoset model of diet-induced obesity and dyslipidemia
- New Insights into the Activation Mechanisms of AMPK
- Discovery of 3, 5-Dimethylpyridin-4 (1H)-one Derivatives as Activators of AMP-Activated Protein Kinase (AMPK)
- Energy deprivation-induced AMPK activation inhibits milk synthesis via PrlR and PGC-1α
- PFKFB2 inhibits ferroptosis in myocardial ischemia/reperfusion injury through AMPK activation.
- Cinnamtannin D1 ameliorates DSS-induced colitis by preventing Th17/Treg imbalance through activation of the AMPK/mTOR pathway
- 588-P: Probing the Role of Muscle Glycogen Resynthesis on Postexercise AMPK Activation and Metabolic Protein Abundance Using a Novel Genetic Model
- Inhibition of osteosarcoma cell proliferation by matrine (MT) via targeting histone H3 lysine 27 trimethylation and AMPK activation
- Betulinic Acid Stimulates Glucose Uptake through the Activation of PI3K and AMPK in 3T3-L1 Adipocytes
- 1507-P: Carnosic Acid–Induced Browning in 3T3-L1 Adipocytes Is Dependent on AMPK Activation
- Maintenance of AMPK activation by metformin is beneficial for suppressing the progress of diabetes-accelerated atherosclerosis via inhibition of vascular smooth …
- The janus face of vascular AMPK activation
- AMPK Activation Protects Against Pulmonary Hypertension in Rats and Relaxes Isolated Human Pulmonary Artery
- … -4-One Isolated from Artemisia princeps Suppresses Adipogenic Differentiation of Human Bone Marrow-Derived Mesenchymal Stromal Cells via Activation of AMPK
- 266-LB: SGLT2 Inhibition Improved Endurance Performance of db/db Mice Accompanied by an Increased Endogenous AMPK Activator in Skeletal Muscles
- Chronic AMPK activation reduces synaptic plasticity markers in Neuronal SH‐SY5Y Cells
- … Li, Benoit Viollet, Ming-Hui Zou, and Zhonglin Xie. AMPK Suppresses Vascular Inflammation In Vivo by Inhibiting Signal Transducer and Activator of Transcription-1 …
- Validation of direct AMP kinase (AMPK) activation for treatment of X-linked Adrenoleukodystrophy
- Withdrawal: Activation of autophagic flux against xenoestrogen bisphenol-A-Induced hippocampal neurodegeneration via AMP kinase (AMPK)/mammalian target of …
- MO019: Preclinical Efficacy of Direct AMPK Activation with a Novel Small Molecule–PXL770–For the Treatment of Autosomal Dominant Polycystic Kidney Disease
- Dual Ampk Activator/mtor Inhibitor Improves Metabolic Parameters in T2d Mice and Protects Cardiomyocytes Against Ischemic Injury
- Oestrogen Receptors ERα, ERβ and GPER Mediate the Activation of AMPK and the Inhibition of the Inflammatory Signaling Pathway TLR4/NFκB in Neutrophils …
- POS-410 THE IMPORTANT FUNCTION OF ADORA2B-MEDIATED AMPK ACTIVATION IN ERYTHROCYTES IN CHRONIC KIDNEY DISEASE
- AMPK Regulates Untimely Transcriptional Activation and R-loop Formation to Protect Genome Stability
- Activation of AMPK Ameliorates Acute Severe Pancreatitis by Suppressing Pancreatic Acinar Cell Necroptosis in Obese Mice Models
- deprivation/reoxygenation‑induced neuronal injury via activation of the AMPK/Nrf2 signaling pathway
- Physcion alleviates chronic alcoholic hepatic inflammation and pyroptosis through SIRT1-AMPK activation
- POS-382 A New AMPK Activator PA-S14 Attenuates Renal Injury through Promoting Autophagy
- 4.8% sevoflurane induces activation of autophagy in human neuroblastoma SH-SY5Y cells by the AMPK/mTOR signaling pathway
- AMPK activation alleviates stroke severity in mice with chronic kidney disease
- Study on the relationship between relieving energy crisis in myofascial trigger points with An-Pressing manipulation and AMPK/PGC-1α pathway activation
- AMPK Activation, A Target of Metformin, is Associated with the Risk of Psoriasis and its Comorbidities in the UK Biobank: A Mendelian Randomization Study
- AMPK activator alleviates pancreatic injury in rat models with severe acute pancreatitis
- Chronic Transient Hypoxia Alleviates High Fat Diet-Induced Obesity and Fatty Liver in C57 Mice by Upregulating Epinephrine Levels and Activation of AMPK
- 5-HEPE reduces obesity and insulin resistance by promoting adipose tissue browning through GPR119/AMPK/PGC1α activation
- Tie2-mediated AMPK activation by ferritin-based protein C nanoparticles inhibits advanced prostate cancer development through induction of vasodilation
- NLRP3 inflammasome activation attenuates neuronal apoptosis by upregulating autophagy through AMPK/Beclin-1 pathway after intracerebral hemorrhage with …
- Novel Duel Mtor Inhibitors/AMPK Activators Improve Therapeutic Efficacy of Doxorubicin and Ameliorate Its Associated Cardiotoxicity in Mice
- Atrial Remodeling is Attenuated by Dual Cannabinoid Receptor Agonist Via AMPK Activation and AERP Reduction
- 1820-P: A Direct AMPK Activator Reduces Liver Steatosis in a Mouse Model of NASH
- … sensing hypothalamic GT1-7 neuronal cells and pancreatic αTC1. 9 α-cells to examine the effect of R481 on AMPK pathway activation and cellular metabolism …
- Facilitation of Glucose Uptake by Lupeol through the Activation of the PI3K/AKT and AMPK Dependent Pathways in 3T3-L1 Adipocytes
- AMPK activation by 5-Amino-4-Imidazole Carboxamide Riboside-1-β-D-Ribofuranoside attenuates alkali Injury-Induced corneal fibrosis
- The anti‐tumourigenic effect of ellagic acid in SKOV‐3 ovarian cancer cells entails activation of autophagy mediated by inhibiting Akt and activating AMPK
- Overexpression of microRNA-9 inhibits 3T3-L1 cell adipogenesis by targeting PNPLA3 via activation of AMPK
- MAP4K3 inhibits Sirtuin-1 to repress the LKB1–AMPK pathway to promote amino acid-dependent activation of the mTORC1 complex
- … BY PROMOTING LIVER-RESIDENT MACROPHAGE NLRP3 INFLAMMASOME ACTIVATION VIA THE INHIBITION OF AMPK/MTOR-MEDIATED AUTOPHAGY …
- White to beige conversion in PDE3B KO adipose tissue through activation of AMPK signaling and mitochondrial function
- Pharmacological activation of AMPK prevents aircraft noise induced oxidative stress, endothelial dysfunction and vascular inflammation
- Author correction: Sirt1 negatively regulates FcεRI-mediated mast cell activation through AMPK-and PTP1B-dependent processes
- ACTIVATOR vs INHIBITOR OF β-ISOFORMS OF AMPK: TOWARDS THE UNDERSTANDING OF ENZYMATIC MECHANISM
- Ginsenoside Rg3 modulates glucose metabolism and ameliorates myocardial insulin resistance through activation of AMPK pathway in TAC-induced heart failure
- Anti-myeloma Effects of Xanthohumol on Human Multiple Myeloma Cells in Vitro via Induction of Apoptosis and Activation of AMPK Pathway
- GLP-1R Activation Ameliorate Novel-object Recognition Function via Hippocampal AMPK/NF-κB Signaling Pathway in Neuropathic Pain Mice
- Metformin protects RPE cells from oxidative damage by enhancing autophagy through activation of AMPK pathway
- Colon Cancer Cell Death by Synergistic Activity of Phytochemicals is Modulated by Increased ROS, Activation of AMPK, and Inhibition of mTORC1
- Artemisinin protected human bronchial epithelial cells from amiodarone-induced oxidative damage via activation of 5’AMP-activated protein kinase (AMPK)
- … to” Saikosaponin A inhibits the activation of pancreatic stellate cells by suppressing autophagy and the NLRP3 inflammasome via the AMPK/mTOR pathway”[Biomed …
- AMPK/mTOR Pathway Mediates Autophagy Activation in Colistin-Induced Nephrotoxicity
- Corrigendum to’Balasubramide derivative 3C modulates microglia activation via CaMKKβ-dependent AMPK/PGC-1α pathway in neuroinflammatory conditions'[Brain …
- Type-2-diabetes: Regulation of AMPK pathway using Natural and Synthetic Activators: A Systematic Review
- The protective effect of artemisinin against hydrogen peroxide-induced oxidative injury in SH-SY5Y and hippocampal neurons via the activation of AMPK
- Protective effect of metformin against hydrogen peroxide induced oxidative damage in RPE cells by enhancing autophagy through activation of AMPK pathway …
- Activation of AMPK by Telmisartan Decreases Basal and PDGF-stimulated VSMC Proliferation via Inhibiting the mTOR/p70S6K Signaling Axis
- Artemisinin prevented D407 cells from amiodarone-induced oxidative damage via activation of CaMKK2/AMPK/Nrf2 signaling pathway
- … inhibition of mitochondrial soluble adenylyl cyclase (sAC) in astrocytes causes activation of AMP-activated protein kinase (AMPK) and induces breakdown of …
- Artemisinin protected human retinal pigment epithelial cells from amiodarone-induced oxidative damage via activation of CaMKK2/AMPK/Nrf2 signaling pathway
- Protective effect of Artemisinin against Hydrogen Peroxide (H2O2)-Induced Oxidative Damage in SH-SY5Y and Hippocampal Neurons through Activation of AMPK …
- Vitamin D3 potentiates the nephroprotective effects of metformin in a rat model of metabolic syndrome: Role of AMPK/SIRT1 activation and DPP-4 inhibition
- AMPK/SIRT1/PGC-1α/SIRT3 pathway-independent activation of GPx1 expression by metformin in the heart of a mouse model of endometriosis
- The beneficial effect of Coix lacryma-jobi var. ma-yuen (Roman.) Stapf sprout the activation of LKB1/AMPK/SIRT1 signaling pathway on obesity
- [Corrigendum] MicroRNA‑506‑3p targets SIRT1 and suppresses AMPK pathway activation to promote hepatic steatosis
- … -Derived Factor-1 (SDF-1) Suppresses the NLRP3 In ammasome and Inhibits Pyroptosis in Synoviocytes from Osteoarthritic Joints via Activation of the AMPK …
- Role of AMPK activation in oxidative cell damage: Implications for alcohol-induced liver disease
- AMPK activation by A-769662 controls IL-6 expression in inflammatory arthritis
- Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction
- Signaling kinase AMPK activates stress-promoted transcription via histone H2B phosphorylation
- Gallic acid regulates body weight and glucose homeostasis through AMPK activation
- Etoposide induces ATM-dependent mitochondrial biogenesis through AMPK activation
- AMPK activation by oncogenesis is required to maintain cancer cell proliferation in astrocytic tumors
- AMPK activation increases fatty acid oxidation in skeletal muscle by activating PPARα and PGC-1
- A potent and selective AMPK activator that inhibits de novo lipogenesis
- Adiponectin represses colon cancer cell proliferation via AdipoR1-and-R2-mediated AMPK activation
- AMP-activated protein kinase (AMPK) activation regulates in vitro bone formation and bone mass
- Role of hepatic AMPK activation in glucose metabolism and dexamethasone-induced regulation of AMPK expression
- AMPK activates autophagy by phosphorylating ULK1
- Anti-adipogenic effect of dioxinodehydroeckol via AMPK activation in 3T3-L1 adipocytes
- Therapeutic metformin/AMPK activation promotes the angiogenic phenotype in the ERα negative MDA-MB-435 breast cancer model
- AMPK activation restores the stimulation of glucose uptake in an in vitro model of insulin-resistant cardiomyocytes via the activation of protein kinase B
- Enhancing AMPK activation during ischemia protects the diabetic heart against reperfusion injury
- Regulation of AMPK activation by CD36 links fatty acid uptake to β-oxidation
- Activation of AMPK attenuates neutrophil proinflammatory activity and decreases the severity of acute lung injury
- Hypoxic activation of AMPK is dependent on mitochondrial ROS but independent of an increase in AMP/ATP ratio
- IRE1-dependent activation of AMPK in response to nitric oxide
- Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity
- Curcumin activates AMPK and suppresses gluconeogenic gene expression in hepatoma cells
- Acetic acid activates hepatic AMPK and reduces hyperglycemia in diabetic KK-A (y) mice
- Activation of AMPK by chitosan oligosaccharide in intestinal epithelial cells: Mechanism of action and potential applications in intestinal disorders
- TAK1 activates AMPK‐dependent cytoprotective autophagy in TRAIL‐treated epithelial cells
- Metformin activates a duodenal Ampk–dependent pathway to lower hepatic glucose production in rats
- LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR‐1
- Fructose-induced hypothalamic AMPK activation stimulates hepatic PEPCK and gluconeogenesis due to increased corticosterone levels
- Resveratrol induces cell apoptosis in adipocytes via AMPK activation
- Selected compounds derived from Moutan Cortex stimulated glucose uptake and glycogen synthesis via AMPK activation in human HepG2 cells
- AMP-activated protein kinase (AMPK) activation is involved in chrysin-induced growth inhibition and apoptosis in cultured A549 lung cancer cells
- Diet and exercise signals regulate SIRT3 and activate AMPK and PGC-1α in skeletal muscle
- Indazole-Type Alkaloids from Nigella sativa Seeds Exhibit Antihyperglycemic Effects via AMPK Activation in Vitro
- The anti-diabetic AMPK activator AICAR reduces IL-6 and IL-8 in human adipose tissue and skeletal muscle cells
- Electroacupuncture improves cognitive deficits associated with AMPK activation in SAMP8 mice
- AMPK activation inhibits apoptosis and tau hyperphosphorylation mediated by palmitate in SH-SY5Y cells
- AMPK activation affects glutamate metabolism in astrocytes
- AMP-Activated Protein Kinase (AMPK) Activation by Benzofurans and Coumestans Isolated from Erythrina abyssinica
- Folic acid supplementation during high-fat diet feeding restores AMPK activation via an AMP-LKB1-dependent mechanism
- … improves the mechanical performance of the post-infarcted diabetic myocardium: a response associated with up-regulation of Akt/mTOR and AMPK activation
- … associated with survival outcomes of colorectal cancer cell but AMPK activator AICAR sensitizes anticancer effect of 5-fluorouracil through AMPK activation
- Inability to maintain GSH pool in G6PD-deficient red cells causes futile AMPK activation and irreversible metabolic disturbance
- Pomegranate vinegar beverage reduces visceral fat accumulation in association with AMPK activation in overweight women: A double-blind, randomized, and …
- Hispidulin sensitizes human ovarian cancer cells to TRAIL-induced apoptosis by AMPK activation leading to Mcl-1 block in translation
- Oxidative stress activates AMPK in cultured cells primarily by increasing cellular AMP and/or ADP
- Acute exercise activates AMPK and eNOS in the mouse aorta
- Pemetrexed indirectly activates the metabolic kinase AMPK in human carcinomas
- Extracellular adenosine activates AMP-dependent protein kinase (AMPK)
- Brief intense interval exercise activates AMPK and p38 MAPK signaling and increases the expression of PGC-1α in human skeletal muscle
- Acadesine activates AMPK and induces apoptosis in B-cell chronic lymphocytic leukemia cells but not in T lymphocytes
- Ionizing radiation activates AMP-activated kinase (AMPK): a target for radiosensitization of human cancer cells
- Resveratrol, an activator of SIRT1, upregulates AMPK and improves cardiac function in heart failure
- Fenofibrate activates AMPK and increases eNOS phosphorylation in HUVEC
- … benzimidazole derivative that potently activates AMPK to increase glucose transport in skeletal muscle: comparison with effects of contraction and other AMPK …
- AMP-activated protein kinase (AMPK) negatively regulates Nox4-dependent activation of p53 and epithelial cell apoptosis in diabetes
- Selective activation of AMPK‐PGC‐1α or PKB‐TSC2‐mTOR signaling can explain specific adaptive responses to endurance or resistance training‐like electrical …
- Activation of AMPK by metformin inhibits TGF-β-induced collagen production in mouse renal fibroblasts
- Glucose deprivation activates AMPK and induces cell death through modulation of Akt in ovarian cancer cells
- Metformin and salicylate synergistically activate liver AMPK, inhibit lipogenesis and improve insulin sensitivity
- Myc-induced AMPK-phospho p53 pathway activates Bak to sensitize mitochondrial apoptosis
- The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK
- Calmodulin-dependent protein kinase kinase-β activates AMPK without forming a stable complex: synergistic effects of Ca2+ and AMP
- Adiponectin activates the AMPK signaling pathway to regulate lipid metabolism in bovine hepatocytes
- Decorin activates AMPK, an energy sensor kinase, to induce autophagy in endothelial cells
- Oxidative stress induces GLUT4 translocation by activation of PI3‐K/Akt and dual AMPK kinase in cardiac myocytes
- Phosphorylation and activation of heart PFK-2 by AMPK has a role in the stimulation of glycolysis during ischaemia
- Cordycepin activates AMP‐activated protein kinase (AMPK) via interaction with the γ1 subunit
- Resveratrol reduces morphine tolerance by inhibiting microglial activation via AMPK signalling
- Adiponectin activation of AMPK disrupts leptin‐mediated hepatic fibrosis via suppressors of cytokine signaling (SOCS‐3)
- Thyroid hormone (T3) rapidly activates p38 and AMPK in skeletal muscle in vivo
- Ischemic preconditioning activates AMPK in a PKC-dependent manner and induces GLUT4 up-regulation in the late phase of cardioprotection
- Activation of the AMPK-ULK1 pathway plays an important role in autophagy during prion infection
- Pre-treatment with metformin activates Nrf2 antioxidant pathways and inhibits inflammatory responses through induction of AMPK after transient global cerebral …
- AMPK α1 Activation Is Required for Stimulation of Glucose Uptake by Twitch Contraction, but Not by H2O2, in Mouse Skeletal Muscle
- Acute renal ischemia rapidly activates the energy sensor AMPK but does not increase phosphorylation of eNOS-Ser1177
- 20 (S)-ginsenoside Rg3 enhances glucose-stimulated insulin secretion and activates AMPK
- A-769662 activates AMPK β1-containing complexes but induces glucose uptake through a PI3-kinase-dependent pathway in mouse skeletal muscle
- FK866-induced NAMPT inhibition activates AMPK and downregulates mTOR signaling in hepatocarcinoma cells
- Honokiol activates the LKB1–AMPK signaling pathway and attenuates the lipid accumulation in hepatocytes
- Methyl-donor supplementation in obese mice prevents the progression of NAFLD, activates AMPK and decreases acyl-carnitine levels
- Bradykinin stimulates endothelial cell fatty acid oxidation by CaMKK-dependent activation of AMPK
- ReishiMax, mushroom based dietary supplement, inhibits adipocyte differentiation, stimulates glucose uptake and activates AMPK
- Nutritional status modulates plasma leptin, AMPK and TOR activation, and mitochondrial biogenesis: implications for cell metabolism and growth in skeletal muscle of …
- … and triterpenes from Moutan Cortex (Paeonia suffruticosa, Paeoniaceae) stimulate glucose uptake and glycogen synthesis via activation of AMPK in insulin-resistant …
- Salicylate activates AMPK and synergizes with metformin to reduce the survival of prostate and lung cancer cells ex vivo through inhibition of de novo lipogenesis
- Small molecule drug A-769662 and AMP synergistically activate naive AMPK independent of upstream kinase signaling
- Inhibition of stearoyl-CoA desaturase1 activates AMPK and exhibits beneficial lipid metabolic effects in vitro
- Akt activation protects pancreatic beta cells from AMPK-mediated death through stimulation of mTOR
- TAK1 activates AMPK-dependent cell death pathway in hydrogen peroxide-treated cardiomyocytes, inhibited by heat shock protein-70
- Palmitate activates mTOR/p70S6K through AMPK inhibition and hypophosphorylation of raptor in skeletal muscle cells: Reversal by oleate is similar to metformin
- Dietary folic acid activates AMPK and improves insulin resistance and hepatic inflammation in dietary rodent models of the metabolic syndrome
- Endoplasmic reticulum stress induced by 2-deoxyglucose but not glucose starvation activates AMPK through CaMKKβ leading to autophagy
- Ultraviolet (UV) and hydrogen peroxide activate ceramide-ER stress-AMPK signaling axis to promote retinal pigment epithelium (RPE) cell apoptosis
- Mild caloric restriction reduces blood pressure and activates endothelial AMPK-PI3K-Akt-eNOS pathway in obese Zucker rats
- Simian virus 40 small T antigen activates AMPK and triggers autophagy to protect cancer cells from nutrient deprivation
- Hypothalamic inhibition of acetyl-CoA carboxylase stimulates hepatic counter-regulatory response independent of AMPK activation in rats
- Isoquercitrin activates the AMP–activated protein kinase (AMPK) signal pathway in rat H4IIE cells
- Phenformin activates the unfolded protein response in an AMP-activated protein kinase (AMPK)-dependent manner
- Metabolomics of the effect of AMPK activation by AICAR on human umbilical vein endothelial cells
- Energy depletion of bovine mammary epithelial cells activates AMPK and suppresses protein synthesis through inhibition of mTORC1 signaling
- 4-O-methylascochlorin, methylated derivative of ascochlorin, stabilizes HIF-1α via AMPK activation
- Apoptolidins A and C activate AMPK in metabolically sensitive cell types and are mechanistically distinct from oligomycin A
- Interleukin-18 activates skeletal muscle AMPK and reduces weight gain and insulin resistance in mice
- Regulation of yeast G protein signaling by the kinases that activate the AMPK homolog Snf1
- PT-1 selectively activates AMPK-γ1 complexes in mouse skeletal muscle, but activates all three γ subunit complexes in cultured human cells by inhibiting the …
- An extract of Artemisia dracunculus L. stimulates insulin secretion from β cells, activates AMPK and suppresses inflammation
- trans-(−)-ε-Viniferin increases mitochondrial sirtuin 3 (SIRT3), activates AMP-activated protein kinase (AMPK), and protects cells in models of Huntington …
- Rheb activates AMPK and reduces p27Kip1 levels in Tsc2-null cells via mTORC1-independent mechanisms: implications for cell proliferation and tumorigenesis
- Urocortin 3 activates AMPK and AKT pathways and enhances glucose disposal in rat skeletal muscle
- Saponarin activates AMPK in a calcium-dependent manner and suppresses gluconeogenesis and increases glucose uptake via phosphorylation of CRTC2 and …
- Adenosine Activates AMPK to Phosphorylate Bcl-XL Responsible for Mitochondrial Damage and DIABLO Release in HuH-7 Cells
- Gefitinib, an EGFR tyrosine kinase inhibitor, activates autophagy through AMPK in human lung cancer cells
- Adiponectin activates endothelial nitric oxide synthase through AMPK signaling after subarachnoid hemorrhage
- Angiotensin II activates AMPK for execution of apoptosis through energy-dependent and-independent mechanisms
- Evodiamine activates AMPK and promotes adiponectin multimerization in 3T3-L1 adipocytes
- PF-4708671 activates AMPK independently of p70S6K1 inhibition
- Apoptotic cells activate AMP-activated protein kinase (AMPK) and inhibit epithelial cell growth without change in intracellular energy stores
- Astrocyte elevated gene-1 activates AMPK in response to cellular metabolic stress and promotes protective autophagy
- AICAR activates AMPK and alters PIP2 association with the epithelial sodium channel ENaC to inhibit Na+ transport in H441 lung epithelial cells
- Liraglutide activates AMPK signaling and partially restores normal circadian rhythm and insulin secretion in pancreatic islets in diabetic mice
- Chlorophyll a, an active anti-proliferative compound of Ludwigia octovalvis, activates the CD95 (APO-1/CD95) system and AMPK pathway in 3T3-L1 cells
- The adenosine derivative 2′, 3′, 5′-tri-O-acetyl-N6-(3-hydroxylaniline) adenosine activates AMPK and regulates lipid metabolism in vitro and in vivo
- Korean red ginseng activates AMPK in skeletal muscle and liver.
- Clozapine activates AMP-activated protein kinase (AMPK) in C2C12 myotube cells and stimulates glucose uptake
- CaMKKα activates AMPK signaling in mouse skeletal muscle in vivo
- Unmetabolized fenofibrate, but not fenofibric acid, activates AMPK and inhibits the expression of phosphoenolpyruvate carboxykinase in hepatocytes
- Rottlerin activates AMPK possibly through LKB1 in vascular cells and tissues
- Estradiol activates AMPK through interaction with extrogen receptor beta (15.4)
- Atorvastatin activates CaMKK-beta as an upstream kinase of AMPK in endothelium
- The 1, 4-naphthoquinone derivative from Pyrola rotundifolia activates AMPK phosphorylation in C2C12 myotubes
- Orexin-A activates hypothalamic ampk signaling through a Ca2+-dependent mechanism involving voltage-gated L-type calcium channel
- Metformin activates duodenal AMPK and a neuronal network to lower glucose production
- Red yeast barley reduces plasma glucose levels and activates AMPK phosphorylation in db/db mice
- Pharmacological activation of 5’AMP-activated protein kinase (AMPK) in vivo acutely decreases blood glucose and chronically increases muscle GLUT4 in normal and …
- Correction: Fenofibrate Improves Renal Lipotoxicity through Activation of AMPK-PGC-1α in db/db Mice
- Curcumin Activates AMPK and SuppressesGluconeogenic Gene Expression in Hepatoma Cells
- … Active Adiponectin Receptor Activator, Attenuates Myocardial Ischemia/Reperfusion Injury by AMPK-Mediated Autophagy and AMPK-Independent Anti-Apoptosis
- Berberine, a natural plant product, activates AMPK with beneficial metabolic effects in diabetic and insulin resistant states
- Conjugated linoleic acid (CLA) activates PGC‐1alpha via AMPK and SIRT1 in C2C12 myotubes
- Resveratrol Activates AMP-Activated Protein Kinase (AMPK) by Increasing LKB1 Activity and AMP/ATP Ratio.
- 2-Deoxyglucose induces Akt phosphorylation via a mechanism independent of LKB1/AMPK signaling activation or glycolysis inhibition
- Activation of AMP-activated protein kinase (AMPK) enhances Radiosensitization via inhibition of mTOR pathway in Rapamycin-resistant non-small cell lung cancer …
- EMD387008, a New Antidiabetic Compound, Inhibits Hepatic Gluconeogenesis through Gluconeogenic Gene Regulation and AMPK Activation.
- B04 AMPK activation alleviates phenotypes associated to the early phases of mutant polyQ cytoxicity
- ATM signaling to mTORC1 in response to DNA damage independent of AMPK activation
- Acute and chronic effects of AMPK activation on skeletal muscle fatty acid and carbohydrate metabolism
- AMPK activation mimics glucose deprivation and induces cytotoxicity in ovarian cancer cells
- AMPK activation is indispensable for the protective effects of caloric restriction on left ventricular function in the postinfarct myocardium
- Research Article Amelioration of LPS-Induced Inflammation Response in Microglia by AMPK Activation
- AMPK activation by adiponectin in renal tubules of control and diabetic rats
- AMP-Activated Protein Kinase (AMPK) Activation and Signalling Following Neuronal Excitotoxicity
- Skeletal muscle and whole-body regulation of substrate partitioning by nutritional and pharmacological AMPK activation.
- Orignal Paper: AMPK activation and Adenine Nucleotide content in skeletal muscle following different types of high fat feeding
- Retraction Note: Lipid metabolism disturbances and AMPK activation in prolonged propofol-sedated rabbits under mechanical ventilation
- Abstract A79: Evidence that the antitumor effects of AMPK activation and crosstalk with the Akt pathway are dependent on the genetic profiles of human breast cancer …
- ANTI-ANGIOGENIC EFFECTS OF METFORMIN, AN AMPK ACTIVATOR, ON HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS
- Nitrogen stress activates AMPK
- Oxidative stress activates AMPK in cultured cells primarily
- Inhibition of hepatic phosphatidylcholine synthesis by AICAR and phenformin is independent of AMP‐activated protein kinase (AMPK) activation.
- Purinergic control of AMPK activation by ATP released through connexin 43 hemichannels: pivotal roles in hemichannel-mediated cell injury
- Estradiol Activates AMPK through Interaction with Estrogen Receptor Beta
- Triterpenoids extracted from bitter melon activate AMPK via a mechanism involving the upstream AMPK kinase CaMKKa/b
- Atypical Antipsychotics Activate Hypothalamic AMPK
- Brief intense interval exercise activates AMPK and p38
- The role of AMP-activate protein kinase (AMPK) in the regulation of cardiac hypertrophy
- Metformin activates AMPK and inhibits insulin secretion in MIN6 cell line culture
- Berberine Activates AMPK in L6 Myotubes by a Mechanism Other Than Via Changes in ATP Levels.
- Canagliflozin Potently Activates AMPK and Inhibits the Growth and Survival of Cancer Cells
- Involvement of AMPK in the Beneficial Vascular Effect of a Non‐selective PPAR Activator in Aorta of Spontaneously Hypertensive Rats
- Selective activation of AMPK in eddothelial cells intensifies high fat diet-induced non-alcoholic fatty liver disease
- The Morphological Investigation Of The Mechanism Of Astragalus Polysaccharide Against Endoplasmic Reticulum Stress By Activation Of AMPK In TIID Rats
- Activation of AMPK Actively Represses Steroid Hormone Synthesis in MA-10 Leydig Cells.
- AMP-activated protein kinase (AMPK) regulates the activation process of hepatic stellate cells
- Adiponectin increases fatty acid oxidation in skeletal muscle cells by sequential activation of AMPK, p38 MAPK, and PPARalpha
- Adiponectin has anti-malignant potential in hepatocellular carcinoma (HCC) by activation of AMPK in HepG2 cells
- Angiotensin II AT2 Receptor Activates AMPK For Execution Of Apoptosis Through Energy-Dependent And-Independent Mechanisms In Primary Pulmonary Artery …
- Activation of AMPK results in ubiquitin-dependent degradation of Foxo1a, a pro-diabetic transcription factor regulating hepatic glucose production
- Apelin Enhances Myocardial Glucose Uptake Through Activation of AMPK and Gq Signaling
- Autophagy is stimulated by energy starvation through activation of AMPK and promotes survival of cardiac myocytes
- Oxidative Stress Induces GLUT4 Translocation by dual AMPK Kinase Activation in Cardiac Myocytes
- Rheb dynamics on lysosomal membranes determines mTORC1 activity after loss of p53 or activation of AMPK
- Deletion of AMPK-Alpha2 intensifies the insulin-induced p70S6K activation in normoxic heart and the isoproterenol-induced ventricular hypertrophy
- PT-1 selectively activates AMPK-1 complexes in mouse skeletal muscle, but activates all three subunit complexes in cultured human cells by inhibiting the …
- Leptin activates α2 AMPK in C2C12 muscle cells through Atm and PI-3kinase/Nur77/CaMKKβ-dependent pathways.
- SALICYLATE ACTIVATES AMPK AND SYNERGIZES WITH METFORMIN TO REDUCE THE SURVIVAL OF PROSTATE AND LUNG CANCERS EX VIVO THROUGH …
- Cryptotanshinone Induces Cell Cycle Arrest and Autophagy of HepG2 Hepatoma via Activation of AMPK Signal Network
- GW26-e0246 Metformin Activate AMPK, Inhibit GRP78 in liver and improve Insulin Sensitivity in Polycystic Ovarian Syndrome Rats
- The NEDD8 Conjugation Pathway Inhibitor MLN4924 Activates AMPK and Induces The ER Stress/UPR-Mediated Cell Death Pathway In Acute Lymphoblastic …
- Capsaicin Activates the Trpv1-camkii-ampk-sirt-1-dependent Mechanism to Trigger Brown Remodeling of White Adipocytes to Antagonize Diet-induced Obesity
- … Peroxide Activates AMP-Activated Protein Kinase in Endothelial Cells by Stimulating Ca2+/Calmodulin-Dependent Protein Kinase Kinase β, and Reveals a Critical Role for eNOS in AMPK …
- Abstract# 2825: Cadmium activates mTOR pathway by upregulating NOX2 and downregulating PTEN and AMPK activity leading to apoptosis of neuronal cells
- 0338: Glucagon-like peptide 1 or GLP-1 counteracts NADPH oxidase activation during hyperglycemia through an AMPK-dependent pathway in adult cardiomyocytes
- 107 A Clinically Important Post-Translational Modification of CTRP9: Proteolytic Cleavage of CTRP9 Yields its Globular Domain, Which Activates AMPK
- Glucagon-Like-Peptide-1 (GLP-1) Activates AMP-Activated Protein Kinase (AMPK) and Diminishes Inflammation in Human Aortic Endothelial Cells (HAECs)
- The Mir-17∼ 92 Cluster Activates mTORC1 Signaling in MCL by Targeting Multiple Regulators of the LKB1/AMPK/mTOR Pathway
- Age-related changes in AMPK activation: Role for AMPK phosphatases and inhibitory phosphorylation by upstream signaling pathways
- Deubiquitination and activation of AMPK by USP10
- AMPK activation: Role in the signaling pathways of neuroinflammation and neurodegeneration
- AMPK activation inhibits the functions of myeloid-derived suppressor cells (MDSC): impact on cancer and aging
- STIM2 interacts with AMPK and regulates calcium-induced AMPK activation
- Systemic pan-AMPK activator MK-8722 improves glucose homeostasis but induces cardiac hypertrophy
- AMPK activation attenuates inflammatory pain through inhibiting NF-κB activation and IL-1β expression
- AMPK activation counteracts cardiac hypertrophy by reducing O-GlcNAcylation
- Inhibition of mitochondrial complex I improves glucose metabolism independently of AMPK activation
- Genetic liver-specific AMPK activation protects against diet-induced obesity and NAFLD
- Hernandezine, a novel AMPK activator induces autophagic cell death in drug-resistant cancers
- AMPK activation reduces hepatic lipid content by increasing fat oxidation in vivo
- Reduced AMPK activation and increased HCAR activation drive anti-inflammatory response and neuroprotection in glaucoma
- PTEN deficiency and AMPK activation promote nutrient scavenging and anabolism in prostate cancer cells
- Desmoplasia suppression by metformin-mediated AMPK activation inhibits pancreatic cancer progression
- Hypoxia, AMPK activation and uterine artery vasoreactivity
- PAN-AMPK activator O304 improves glucose homeostasis and microvascular perfusion in mice and type 2 diabetes patients
- AMPK activation protects cells from oxidative stress‐induced senescence via autophagic flux restoration and intracellular NAD+ elevation
- AMPK activates LXRα and ABCA1 expression in human macrophages
- Metformin activates AMPK through the lysosomal pathway
- AMPK directly activates mTORC2 to promote cell survival during acute energetic stress
- Mitochondria-derived ROS activate AMP-activated protein kinase (AMPK) indirectly
- FGF21 activates AMPK signaling: impact on metabolic regulation and the aging process
- Rosmarinic acid activates AMPK to inhibit metastasis of colorectal cancer
- Mitochondrial dysfunction activates the AMPK signaling and autophagy to promote cell survival
- The Na+/Glucose Cotransporter Inhibitor Canagliflozin Activates AMPK by Inhibiting Mitochondrial Function and Increasing Cellular AMP Levels
- Green tea extract activates AMPK and ameliorates white adipose tissue metabolic dysfunction induced by obesity
- AMPK activates FOXO3a and promotes neuronal apoptosis in the developing rat brain during the early phase after hypoxia-ischemia
- Dietary luteolin activates browning and thermogenesis in mice through an AMPK/PGC1α pathway-mediated mechanism
- Exercise activates lysosomal function in the brain through AMPK‐SIRT1‐TFEB pathway
- Moderate Exercise Suppresses NF-κB Signaling and Activates the SIRT1-AMPK-PGC1α Axis to Attenuate Muscle Loss in Diabetic db/db Mice
- miR-135b expression downregulates Ppm1e to activate AMPK signaling and protect osteoblastic cells from dexamethasone
- Palmitate induces mitochondrial superoxide generation and activates AMPK in podocytes
- Metformin activates the protective effects of the AMPK pathway in acute lung injury caused by paraquat poisoning
- Omega-3 fatty acids-enriched fish oil activates AMPK/PGC-1α signaling and prevents obesity-related skeletal muscle wasting
- Cyanidin-3-O-β-glucoside and protocatechuic acid activate AMPK/mTOR/S6K pathway and improve glucose homeostasis in mice
- Hesperetin is a potent bioactivator that activates SIRT1-AMPK signaling pathway in HepG2 cells
- Mesenchymal stem cells-derived IL-6 activates AMPK/mTOR signaling to inhibit the proliferation of reactive astrocytes induced by hypoxic-ischemic brain damage
- Mitochondrial uncoupler BAM15 inhibits artery constriction and potently activates AMPK in vascular smooth muscle cells
- Targeting PP2A activates AMPK signaling to inhibit colorectal cancer cells
- Naringin activates AMPK resulting in altered expression of SREBPs, PCSK9, and LDLR to reduce body weight in obese C57BL/6J mice
- Rosmarinic acid, a rosemary extract polyphenol, increases skeletal muscle cell glucose uptake and activates AMPK
- Cordycepin activates autophagy through AMPK phosphorylation to reduce abnormalities in Machado–Joseph disease models
- Glutaredoxins concomitant with optimal ROS activate AMPK through S-glutathionylation to improve glucose metabolism in type 2 diabetes
- Pancreastatin inhibitor activates AMPK pathway via GRP78 and ameliorates dexamethasone induced fatty liver disease in C57BL/6 mice
- High uric acid activates the ROS-AMPK pathway, impairs CD68 expression and inhibits OxLDL-induced foam-cell formation in a human monocytic cell line …
- Genotoxic Damage Activates the AMPK-α1 Isoform in the Nucleus via Ca2+/CaMKK2 Signaling to Enhance Tumor Cell Survival
- Frontline Science: D1 dopaminergic receptor signaling activates the AMPK-bioenergetic pathway in macrophages and alveolar epithelial cells and reduces endotoxin …
- PKA activates AMPK through LKB1 signaling in follicular thyroid cancer
- Curcumin activates AMPK pathway and regulates lipid metabolism in rats following prolonged clozapine exposure
- EBV-miR-BART1-5P activates AMPK/mTOR/HIF1 pathway via a PTEN independent manner to promote glycolysis and angiogenesis in nasopharyngeal …
- Insulin-like growth factor-1 activates AMPK to augment mitochondrial function and correct neuronal metabolism in sensory neurons in type 1 diabetes
- Chrysanthemum indicum Inhibits Adipogenesis and Activates the AMPK Pathway in High-Fat-Diet-Induced Obese Mice
- Compound 13 activates AMPK-Nrf2 signaling to protect neuronal cells from oxygen glucose deprivation-reoxygenation
- Probing the enzyme kinetics, allosteric modulation and activation of α1-and α2-subunit-containing AMP-activated protein kinase (AMPK) heterotrimeric complexes by …
- Amarogentin, a secoiridoid glycoside, activates AMP-activated protein kinase (AMPK) to exert beneficial vasculo-metabolic effects
- Cryptotanshinone activates AMPK-TSC2 axis leading to inhibition of mTORC1 signaling in cancer cells
- Phosphodiesterase 4 inhibitor activates AMPK-SIRT6 pathway to prevent aging-related adipose deposition induced by metabolic disorder
- Butein activates autophagy through AMPK/TSC2/ULK1/mTOR pathway to inhibit IL-6 expression in IL-1β stimulated human chondrocytes
- Perfluorooctanoic acid exposure alters polyunsaturated fatty acid composition, induces oxidative stress and activates the AKT/AMPK pathway in mouse epididymis
- Metformin activates KDM2A to reduce rRNA transcription and cell proliferation by dual regulation of AMPK activity and intracellular succinate level
- Zinc reduces hepatic lipid deposition and activates lipophagy via Zn2+/MTF‐1/PPARα and Ca2+/CaMKKβ/AMPK pathways
- Epigallocatechin-3-gallate (EGCG) activates AMPK through the inhibition of glutamate dehydrogenase in muscle and pancreatic ß-cells: A potential beneficial effect in …
- Berberine activates AMPK to suppress proteolytic processing, nuclear translocation and target DNA binding of SREBP-1c in 3T3-L1 adipocytes
- PP2A catalytic subunit silence by microRNA-429 activates AMPK and protects osteoblastic cells from dexamethasone
- The red pepper’s spicy ingredient capsaicin activates AMPK in HepG2 cells through CaMKKβ
- Knockdown of MAGEA6 activates AMP-activated protein kinase (AMPK) signaling to inhibit human renal cell carcinoma cells
- Two isoprenylated flavonoids from Dorstenia psilurus activate AMPK, stimulate glucose uptake, inhibit glucose production and lower glycemia
- Cichoric acid regulates the hepatic glucose homeostasis via AMPK pathway and activates the antioxidant response in high glucose-induced hepatocyte injury
- A collagen domain–derived short adiponectin peptide activates APPL1 and AMPK signaling pathways and improves glucose and fatty acid metabolisms
- GSK621 activates AMPK signaling to inhibit LPS-induced TNFα production
- Lactate administration activates the ERK 1/2, mTORC 1, and AMPK pathways differentially according to skeletal muscle type in mouse
- Zanthoxylum alkylamides activate phosphorylated AMPK and ameliorate glycolipid metabolism in the streptozotocin-induced diabetic rats
- Danzhi Qing’e (DZQE) activates AMPK pathway and regulates lipid metabolism in a rat model of perimenopausal hyperlipidaemia
- The GLP-1 receptor agonists exenatide and liraglutide activate Glucose transport by an AMPK-dependent mechanism
- PF-06409577 activates AMPK signaling to protect retinal pigment epithelium cells from UV radiation
- Exenatide Activates the APPL1-AMPK-PPARα Axis to Prevent Diabetic Cardiomyocyte Apoptosis
- Relaxin activates AMPK-AKT signaling and increases glucose uptake by cultured cardiomyocytes
- TRB3 gene silencing activates AMPK in adipose tissue with beneficial metabolic effects in obese and diabetic rats
- Novel chemotherapeutic agent, FND-4b, activates AMPK and inhibits colorectal cancer cell proliferation
- AMPK activates DAPK2 to promote autophagy
- Camptothecin activates SIRT1 to promote lipid catabolism through AMPK/FoxO1/ATGL pathway in C2C12 myogenic cells
- Reserpine treatment activates AMP activated protein kinase (AMPK)
- Correction to: Cryptotanshinone activates AMPK-TSC2 axis leading to inhibition of mTORC1 signaling in cancer cells
- CB2 receptor agonist JWH133 activates AMPK to inhibit growth of C6 glioma cells
- The miR-17~ 92 cluster activates mTORC1 in mantle cell lymphoma by targeting multiple regulators in the STK11/AMPK/TSC/mTOR pathway
- Voluntary wheel running activates Akt/AMPK/eNOS signaling cascades without improving profound endothelial dysfunction in mice deficient in α …
- IL‐15 Activates Akt Independent of AMPK Signaling in Cardiomyocytes
- Metformin Activates AMPK Signaling but Inhibits Mitophagy in the Mouse Heart
- AdipoRon, pan‐adiponectin receptor agonist, activates mitochondrial metabolism via AMPK‐PGC1α pathway in the skeletal muscle
- Corrigendum to “Zanthoxylum ailanthoides Suppresses Oleic Acid-Induced Lipid Accumulation through an Activation of LKB1/AMPK Pathway in HepG2 Cells”
- Protective effects of Shenlingbaizhu powder against non-alcoholic fatty liver disease in rats through activation of SIRT3/AMPK/ACC signaling pathways
- 166-LB: Canagliflozin but Not Empagliflozin Activates AMPK and Suppresses Colon Cancer Cell Growth
- No Protective Effect of Constitutive Activation of AMPK in Endothelial Cells on Vascular Function in Aged Obese Mice but Augmented α1-Adrenergic Contractions in …
- Corrigendum to” Activation of AMPK by berberine induces hepatic lipid accumulation by upregulation of fatty acid translocase CD36 in mice”[Toxicol. Appl. Pharmacol …
- … Activation by Pterostilbene Ameliorates Acute Doxorubicin Cardiotoxicity via Reducing Mitochondrial Oxidative Stress Through Enhancing Ampk and Sirt1 Cascades
- PM2. 5 Exposure Induced Autophagy Activation via the ROS/AMPK/mTOR/ULK1 Signaling Axis in Macrophages
- Mechanism of Activation of AMPK/P53-CyPD Signalling Pathway in Inhibiting Osteoblast Apoptosis Induced by Dexamethasone.
- AMPK Phosphorylation Modulates Pain by Activation of NLRP3 Inflammasome
- Regulation of lipid metabolism by strawberry extracts through AMP-activated protein kinase (AMPK) activation in HepG2 and 3T3-L1 cells
- Activation of AMPK-Activated Protein Kinases Prevents Atrial Fibrillation
- Glut5‐KD reduces blood pressure via increases phosphorylation of nNOS and decreases NADPH oxidase by AMPK activation in the NTS of fructose‐induced …
- Abstract P5-04-08: Timing provides context for the paradoxical effects of AMPK activation in ER+ breast cancer: Suppressing growing tumors, but promoting dormant …
- AMPK Protects against lps-induced endothelial hyperpermeability via activation of p38 mapk/hsp27 pathway and control of junctional proteins expression
- Retraction: Probucol suppresses human glioma cell proliferation in vitro via ROS production and LKB1-AMPK activation
- Mechanisms of activation and inhibition of the metabolic regulator AMP-activated protein kinase (AMPK)
- Retracted: Safranal induces autophagy by AMPK activation and protects neurons against amyloid beta in Alzheimer’s disease
- Metabolic stress in glaucoma engages early activation of the energy biosensor AMPK leading to neuronal dysfunction
- FA-5, a novel AMP-activated protein kinase (AMPK) activator, as a new pharmacological tool for the management of bowel inflammation
- Specific Sirt1 Activator-mediated Improvement in Glucose Homeostasis Requires Sirt1-Independent Activation of AMPK
- Liver-specific activation of AMPK prevents steatosis on a high fructose diet
- Metformin enhances intestinal epithelial health through activation of AMPK
- The effects of NT-1044, a novel AMPK activator, on endometrial cancer cell proliferation, apoptosis, cell stress, and tumor growth
- Antiproliferative effects of cimicifuga racemosa root extract Ze 450 mediated by inhibition of oxidative phosphorylation and indirect AMPK activation
- 119-OR: Amplified Glucagon Response to Hypoglycemia following AMP-Activated Protein Kinase (AMPK) Activator R481 Treatment in Healthy Rats
- 202 AMPK Activation Partially Restores the Anti-Contractile Effect of Perivascular Adipose Tissue in Female Offspring of Obese Rats
- Extracellular citrate impacts hypothalamic mitochondrial function and activates AMPK
- Adiponectin Through AMPK‐dependent Nuclear STAT3 Activation Facilitates Ischemic Postconditioning Cardioprotection
- Balasubramide derivative 3C modulates microglia activation via CaMKKb-dependent AMPK/PGC-1a pathway in neuroinflammatory conditions
- … Diabetes-induced Autophagic Flux Arrestment in Ischemic/Reperfused Heart by Adiponectin Receptor Activation Involves Both AMPK-Dependent and AMPK …
- Mechanism of the AMPK-dependent activation of eukaryotic elongation factor 2 kinase (eEF-2K)
- Elevation of Serum Fibroblast Growth Factor 21 in Patients With Acute Myocardial Infarction: A Potential Role of Ampk Activation Following Sympathetic Overdrive
- Protective effect of Metformin against H2O2-induced oxidative damage in neuronal cells through activation of AMPK pathway
- Abstract PD2-01: Clinically dormant ER+ breast tumors exhibit AMPK activation
- P6070 Oxidized low-density lipoprotein, in contrast to inflammatory cytokines, activates AMPK-ACC signaling in human platelets
- Activation of Liver AMPK with PF-06409577 Corrects NAFLD and Lowers Cholesterol in Rodent and Primate Preclinical Models
- The inhibitory role of Kaempferol-3-O-rutinoside induced AMPK activation on the growth of human breast cancer cell lines
- Cell contact activates AMP-Activated Protein Kinase (AMPK) through CaMKKβ and the GTPase Rac1
- Salicylate sensitizes prostate cancer (PrCa) to radiotherapy; activation of AMPK and suppression of lipogenesis
- Activation of the intracellular Ca++-AMPK pathway ameliorates apoptosis and improves autophagy in diabetic peripheral neuropathy
- Carnosic acid activates AMPK, inhibits Akt and inhibits H1299 human lung cancer cell survival
- P3812 AMPK/PGC1 activation by melatonin attenuates acute doxorubicin cardiotoxicity
- Selenium-Binding Protein 1 Reduces Oxygen Consumption and Activates AMPK in Prostate Cancer Cells (OR11-04-19)
- Estrogen Receptor alpha interferes with LKBl/AMPK/mTOR signaling activation in adiponectin-treated breast cancer cells
- The Pro-Hypertrophic High Molecular Weight Fgf2 Activates Ampk or Erk by Engaging, Respectively, Fgfr1-Independent or Fgfr1-Dependent Pathways
- P1. 03-03 Inhibition of H1299 Lung Cancer Cell Proliferation and Survival by Rosemary Extract Is Associated with AMPK Activation
- Perfluorooctanoic Acid Exposure Alters Polyunsaturated Fatty Acid Composition, Induces Oxidative Stress and Activates the AKT/AMPK Pathway in Mouse …
- IGF-1 activates AMPK to regulate mitochondrial fission/fusion proteins in adult rat sensory neurons
- Abstract C122: NUC-7738, a novel ProTide modification of 3′-deoxyadenosine, activates AMPK and kills renal cancer cells in vitro
- Resveratrol activates neuronal autophagy through AMPK in the ischemic brain
- The aldolase inhibitor aldometanib mimics glucose starvation to activate lysosomal AMPK
- AMPK activates Parkin independent autophagy and improves post sepsis immune defense against secondary bacterial lung infections
- SirT3 activates AMPK-related mitochondrial biogenesis and ameliorates sepsis-induced myocardial injury
- Metformin activates AMPK/SIRT1/NF-κB pathway and induces mitochondrial dysfunction to drive caspase3/GSDME-mediated cancer cell pyroptosis
- Glucose limitation activates AMPK coupled SENP1-Sirt3 signalling in mitochondria for T cell memory development
- High fat activates O-GlcNAcylation and affects AMPK/ACC pathway to regulate lipid metabolism
- CARS senses cysteine deprivation to activate AMPK for cell survival
- AMPK activates the Nrf2-Keap1 pathway to govern dendrite pruning via the insulin pathway in Drosophila
- Rifampicin activates AMPK and alleviates oxidative stress in the liver as mediated with Nrf2 signaling
- Testosterone activates glucose metabolism through AMPK and androgen signaling in cardiomyocyte hypertrophy
- Polyphyllin I activates AMPK to suppress the growth of non-small-cell lung cancer via induction of autophagy
- lncRNA Oip5‐as1 attenuates myocardial ischaemia/reperfusion injury by sponging miR‐29a to activate the SIRT1/AMPK/PGC1α pathway
- A sulfonamide chalcone AMPK activator ameliorates hyperglycemia and diabetic nephropathy in db/db mice
- Active vitamin D activates chondrocyte autophagy to reduce osteoarthritis via mediating the AMPK–mTOR signaling pathway
- Dihydroquercetin activates AMPK/Nrf2/HO-1 signaling in macrophages and attenuates inflammation in LPS-induced endotoxemic mice
- Regulation of AMPK activation by extracellular matrix stiffness in pancreatic cancer
- Alpha-lipoic acid activates AMPK to protect against oxidative stress and apoptosis in rats with diabetic peripheral neuropathy
- Amyloid‐β activates NLRP3 inflammasomes by affecting microglial immunometabolism through the Syk‐AMPK pathway
- Ouabain impairs cancer metabolism and activates AMPK-Src signaling pathway in human cancer cell lines
- AMPK activation improves recovery from pneumonia-induced lung injury via reduction of er-stress and apoptosis in alveolar epithelial cells
- l-Theanine Activates the Browning of White Adipose Tissue Through the AMPK/α-Ketoglutarate/Prdm16 Axis and Ameliorates Diet-Induced Obesity in Mice
- Dapagliflozin ameliorates pancreatic injury and activates kidney autophagy by modulating the AMPK/mTOR signaling pathway in obese rats
- Caffeic and chlorogenic acids synergistically activate browning program in human adipocytes: Implications of AMPK-and PPAR-mediated pathways
- ZEA-induced autophagy in TM4 cells was mediated by the release of Ca2+ activates CaMKKβ-AMPK signaling pathway in the endoplasmic reticulum
- Empagliflozin activates Sestrin2-mediated AMPK/mTOR pathway and ameliorates lipid accumulation in obesity-related nonalcoholic fatty liver disease
- Glucose activates the primordial follicle through the AMPK/mTOR signaling pathway
- miR-107 inhibition upregulates CAB39 and activates AMPK-Nrf2 signaling to protect osteoblasts from dexamethasone-induced oxidative injury and …
- The novel non‐steroidal MR antagonist finerenone improves metabolic parameters in high‐fat diet‐fed mice and activates brown adipose tissue via AMPK‐ATGL …
- CTRP3 activates the AMPK/SIRT1-PGC-1α pathway to protect mitochondrial biogenesis and functions in cerebral ischemic stroke
- IL11 stimulates ERK/P90RSK to inhibit LKB1/AMPK and activate mTOR initiating a mesenchymal program in stromal, epithelial, and cancer cells
- Mitochondrial ATP and Labile Fe (II) Pool Simultaneous Imaging in Ferroptosis Regulated by Energy-Stress Mediated AMPK Activation
- Quercetin activates the Sestrin2/AMPK/SIRT1 axis to improve amyotrophic lateral sclerosis
- Lactate Activates AMPK Remodeling of the Cellular Metabolic Profile and Promotes the Proliferation and Differentiation of C2C12 Myoblasts
- Limonin, a novel AMPK activator, protects against LPS-induced acute lung injury
- Alkaline intracellular pH (pHi) activates AMPK–mTORC2 signaling to promote cell survival during growth factor limitation
- Dietary phosphorus reduced hepatic lipid deposition by activating Ampk pathway and beclin1 phosphorylation levels to activate lipophagy in tilapia …
- Glioblastoma stem cell (GSC)-derived PD-L1-containing exosomes activates AMPK/ULK1 pathway mediated autophagy to increase temozolomide-resistance …
- Dehydroepiandrosterone activates the GPER-mediated AMPK signaling pathway to alleviate the oxidative stress and inflammatory response in laying hens fed with …
- Metformin Activates the AMPK-mTOR Pathway by Modulating lncRNA TUG1 to Induce Autophagy and Inhibit Atherosclerosis
- Stevioside activates AMPK to suppress inflammation in macrophages and protects mice from LPS-induced lethal shock
- Carnosic acid and carnosol activate AMPK, suppress expressions of gluconeogenic and lipogenic genes, and inhibit proliferation of HepG2 cells
- Long-term caloric restriction activates the myocardial SIRT1/AMPK/PGC-1α pathway in C57BL/6J male mice
- … -Resveratrol Attenuates Oxidative Stress, Adipogenesis and Insulin Resistance in In Vitro Models and High-Fat Diet-Induced Mouse Model via AMPK Activation
- Punicalagin Activates AMPK/PGC‐1α/Nrf2 Cascade in Mice: The Potential Protective Effect against Prenatal Stress
- The Natural Chemotherapeutic Capsaicin Activates AMPK through LKB1 Kinase and TRPV1 Receptors in Prostate Cancer Cells
- PF-06409577 activates AMPK signaling and inhibits osteosarcoma cell growth
- Linear ubiquitination of LKB1 activates AMPK pathway to inhibit NLRP3 inflammasome response and reduce chondrocyte pyroptosis in osteoarthritis
- Broccoli-Derived Glucoraphanin Activates AMPK/PGC1α/NRF2 Pathway and Ameliorates Dextran-Sulphate-Sodium-Induced Colitis in Mice
- LncRNA GAS5 activates the AMPK pathway in peripheral blood mononuclear cells derived from rheumatoid arthritis patients
- Maslinic acid activates renal AMPK/SIRT1 signaling pathway and protects against diabetic nephropathy in mice
- A phytoestrogen secoisolariciresinol diglucoside induces browning of white adipose tissue and activates non-shivering thermogenesis through AMPK pathway
- A subset of VEGFR‐TKIs activates AMPK in LKB1‐mutant lung cancer
- Rosemary extract increases neuronal cell glucose uptake and activates AMPK
- Rutaecarpine Mitigates Cognitive Impairment by Balancing Mitochondrial Function Through Activation of the AMPK/PGC1α Pathway
- Propofol activates AMPK to inhibit the growth of HepG2 cells in vitro and hepatocarcinogenesis in xenograft mouse tumor models by inducing autophagy
- Porcine epidemic diarrhoea virus (PEDV) infection activates AMPK and JNK through TAK1 to induce autophagy and enhance virus replication
- Exercise activates AMPK signaling: Impact on glucose uptake in the skeletal muscle in aging
- Bioactive compounds from Artemisia dracunculus L. activate AMPK signaling in skeletal muscle
- Xanthohumol protect against acetaminophen-induced hepatotoxicity via Nrf2 activation through the AMPK/Akt/GSK3β pathway
- The mechanisms of hydroxy-α-sanshool from Zanthoxyum bungeanum maxim activates AMPK-HIF1-PKM2 pathway to fix the obesity
- Ming-mu-di-huang-pill activates SQSTM1 via AMPK-mediated autophagic KEAP1 degradation and protects RPE cells from oxidative damage
- WSSV exploits AMPK to activate mTORC2 signaling for proliferation by enhancing aerobic glycolysis
- Potent PDE4 inhibitor activates AMPK and Sirt1 to induce mitochondrial biogenesis
- Three-Dimensional Matrix Stiffness Activates the Piezo1-AMPK-Autophagy Axis to Regulate the Cellular Osteogenic Differentiation
- Linggui Zhugan Decoction activates the SIRT1-AMPK-PGC1α signaling pathway to improve mitochondrial and oxidative damage in rats with chronic heart …
- Camptothecin Inhibits Neddylation to Activate the Protective Autophagy Through NF-κB/AMPK/mTOR/ULK1 Axis in Human Esophageal Cancer Cells
- Nitric oxide activates AMPK by modulating PDE3A in human pulmonary artery smooth muscle cells
- … of bioassay and non-target metabolite analysis of tomato reveals that β-carotene and lycopene activate the adiponectin signaling pathway, including AMPK …
- Epidermal growth factor activates EGFR/AMPK signalling to up-regulate the expression of SGLT1 and GLUT2 to promote intestinal glucose absorption in …
- Diosmetin inhibits apoptosis and activates AMPK‐induced autophagy in myocardial damage under hypoxia environment
- 4‐O‐methylascochlorin activates autophagy by activating AMPK and suppressing c‐Myc in glioblastoma
- Cell adhesion molecule IGPR-1 activates AMPK connecting cell adhesion to autophagy
- … galactooligosaccharide intervention alters the metabolic profile, improves the antioxidant capacity of mitochondria and activates the AMPK/Nrf2 signaling pathway in …
- Atomoxetine and Fluoxetine Activate AMPK-ACC-CPT1 Pathway in Human SH-SY5Y and U-87 MG Cells
- DJ-1 activates the AMPK/mTOR pathway by binding RACK1 to induce autophagy and protect the myocardium from ischemia/hypoxia injury
- Hedgehog signal activates AMPK via Smoothened to promote autophagy and lipid degradation in hepatocytes
- Rosemary extract activates AMPK, inhibits mTOR and attenuates the high glucose and high insulin-induced muscle cell insulin resistance
- IL11 stimulates ERK/P90RSK to inhibit LKB1/AMPK and activate mTOR in hepatocytes, the stroma and cancer cells
- Foam cell induction activates AMPK but uncouples its regulation of autophagy and lysosomal homeostasis
- … , a sulfur compound in aged garlic extract, alleviates cold‑induced reduction in peripheral blood flow in rat via activation of the AMPK/eNOS/NO pathway
- β-hydroxybutyrate and hydroxycarboxylic acid receptor 2 agonists activate the AKT, ERK and AMPK pathways, which are involved in bovine neutrophil …
- Activation of SNF1/AMPK mediates the mitochondrial derepression, resistance to oxidative stress and increased lifespan of cells lacking the phosphatase Sit4p
- Whole body vibration activates AMPK/CPT1 signaling pathway of skeletal muscle in young and aging mice based on metabolomics study
- … of genistein on the production performance and lipid metabolism disorders in laying hens with fatty liver hemorrhagic syndrome by activation of the GPER-AMPK …
- Alisol A-24-acetate promotes glucose uptake via activation of AMPK in C2C12 myotubes
- Salvianolic acid C promotes osteogenic differentiation of bone marrow mesenchymal stem cells in osteoporotic rats through activation of AMPK/SIRT1 pathway
- A Box-Behnken design for optimal green extraction of compounds from olive leaves that potentially activate the AMPK pathway
- Chronic Activation of AMPK Induces Mitochondrial Biogenesis through Differential Phosphorylation and Abundance of Mitochondrial Proteins in Dictyostelium …
- Anti-Obesity Effect of Dyglomera® Is Associated with Activation of the AMPK Signaling Pathway in 3T3-L1 Adipocytes and Mice with High-Fat Diet-Induced …
- 3H-1, 2-dithiole-3-thione protects lens epithelial cells against fructose-induced epithelial-mesenchymal transition via activation of AMPK to eliminate AKR1B1-induced …
- Identification of Stabilization of Malvid Anthocyanins and Antioxidant Stress Activation via the AMPK/SIRT1 Signaling Pathway
- Carbon monoxide exposure activates ULK1 via AMPK phosphorylation in murine embryonic fibroblasts
- AMPK activation induces RALDHhigh tolerogenic dendritic cells through rewiring of glucose and lipid metabolism
- Myeloid differential protein-2 inhibition improves diabetic cardiomyopathy via p38MAPK inhibition and AMPK pathway activation
- Limonin, an AMPK Activator, Inhibits Hepatic Lipid Accumulation in High Fat Diet Fed Mice
- Role of inorganic polyphosphates in the activation of AMPK in models of Alzheimer’s disease
- The Protective Effect of 11-Keto-β-Boswellic Acid against Diabetic Cardiomyopathy in Rats Entails Activation of AMPK
- Activation of FXR receptor reduces damage of ET-1 on H9C2 cardiomyocytes by activating AMPK signaling pathway.
- Moving towards isoform-specific AMPK activation
- EP16. 04-008 Cytotoxic Effects of Carnosic Acid Are Mediated by Induction of Autophagy and Activation of Sestrin-2/LKB1/AMPK Signalling in H1299 NSCLC Cells
- Effects of AMPK activator and inhibitor on penetrating Transplantation
- Dapagliflozin activates AMPK to attenuate cardiac dysfunction and oxidative stress under hypoxia/reoxygenation-caused damage
- 25-Hydroxycholesterol Regulates Lysosome AMPK Activation and Metabolism Reprograming to Educate Immunosuppressive Macrophages
- Adiponectin inhibits palmitic acid-induced NLRP3 inflammasome activation in hepatocytes through AMPK-JNK/ErK1/2-NFκB/ROS signaling pathways
- AMPK Activates ULK1 in Skeletal Muscle Without Increasing Markers of Autophagy
- The Antitumor Effect of Capsaicin on Prostate Cancer Cells Depends on AMPK Activation Through LKB1 Kinase and TRPV1 Receptor
- Cell adhesion molecule IGPR-1 activates AMPK connecting cell adhesion to energy sensing and autophagy
- Correction to: context-dependent AMPK activation distinctly regulates TAp73 stability and transcriptional activity
- Heat-Killed Lactiplantibacillus plantarum APSulloc 331261 Enhances Lipid Catabolism Through AMPK Activation in HepG2 Cells
- The Effects of NT-1044, a Novel AMPK Activator, on Endometrial Cancer Cell Proliferation, Apoptosis, Cell Stress and In Vivo Tumor Growth
- Duodenal-jejunal bypass surgery activates eNOS and enhances antioxidant system by activating AMPK pathway to improve oxidative stress diabetic cardiomyopathy
- β-aminoisobutyric Acid, a Metabolite of BCAA, Activates the AMPK/Nrf-2 Pathway to Prevent Ferroptosis and Ameliorates Lung Ischemia-Reperfusion Injury
- Sitagliptin via the activation of AMPK/eNOS signaling improves vascular endothelial function by suppressing Creb5/lncRNA ENSMUST00000213271 axis in obese …
- AMPK activation alleviated dextran sulfate sodium-induced colitis by inhibiting ferroptosis
- AICAR-induced activation of AMPK inhibits the migration of TSCC cells by targeting ZO-1
- Dietary cannabidiol activates PKA/ERK/AMPK signaling and attenuates chronic inflammation and leaky gut in DSS-induced colitis mice
- Comparative study of callus culture and leaves of Thunbergia laurifolia for their bioactive constituents and the activation of AMPK and GLUT‐dependent glucose …
- Atherosclerosis is attenuated by acacetin via Sirt1-mediated activation of AMPK/Sirt3 signals in diabetic ApoE−/− mice
- … sensing hypothalamic GT1-7 neuronal cells and pancreatic αTC1. 9 α-cells to examine the effect of R481 on AMPK pathway activation and cellular metabolism …
- Testosterone activates glucose metabolism through AMPK and androgen signaling in cardiomyocyte hypertrophy
- AMPK blocks chromatin activation and consequent R-loop formation to protect genome stability following acute starvation
- Increased macrophage activation mediated by caspase recruitment domain 6 knockdown through negatively targeting AMPK
- Nandrolone supplementation promotes AMPK activation and divergent 18 [FDG] PET brain connectivity in adult and aged mice
- Herbal medicine of Kursi Wufarikun Ziyabit inhibits mitochondrial ATP production to activate AMPK in hepatocytes in therapy of type 2 diabetes
- Exosomal microRNA-122 from HCC inhibits hepatic stellate cell fibrosis activation via AMPK signaling.
- 386-P: Chronic Treatment with the Direct AMPK Activator PXL770 Improves Cardiac, Vascular, and Renal Function in Rodents with Diabetes-Related Cardiorenal …
- Quercetin activates autophagy suppresses apoptosis, inflammation and cartilage matrix degradation in LPS-induced chondrocytes through targeting AMPK/mTOR …
- Metformin activates AMPK to alleviate acute fulminant hepatitis induced by concanavalin A in mice
- … INDUCES POSTMENOPAUSAL HYPERTENSIVE HYPERTROPHY THROUGH INHIBITING THE ACTIVATION OF AMPK-FOXO1/MURF1 SIGNALING PATHWAY
- AICAR activates AMPK to regulate STAT3 nuclear translocation and phosphorylation and iNOS expression in inflammatory pain
- 199-OR: Exercise Decreases Mouse and Human Islet Senescence through Glucagon-Mediated AMPK Activation
- Citrulline and arginine activate eNOS via AMPK and increase retinal endothelial cell permeability
- Themes: Title: Anti-angiogenic effects of Metformin, an AMPK activator, on Human Umbilical Vein Endothelial Cells
- Metformin and Carvedilol ameliorate isoprenaline-induced myocardial infarction in non-diabetic rats through AMPK activation and suppression of apoptosis
- The Role of Adenosine Monophosphate Protein Kinase (AMPK) Activation In Francisella tularensis Intracellular Replication
- Salvianolic acid A activates AMPK and SIRT1 to reduce palmitic acid-induced lipotoxicity in hepatocyte
- Correction: EBV-miR-BART1-5P activates AMPK/mTOR/HIF1 pathway via a PTEN independent manner to promote glycolysis and angiogenesis in nasopharyngeal …
- … Factor-κB (NF-κB)-Regulated Adenosine Monophosphate Activated Protein Kinase (AMPK)/Mammalian Target of Rapamycin (mTOR) Signaling Pathway to Activate …
