AMPK ACTIVATORS
December 8, 2023AMYLIN
December 8, 2023
- Adapting proteostasis for disease intervention
- Biological and chemical approaches to diseases of proteostasis deficiency
- Proteostasis and aging
- The proteostasis network and its decline in ageing
- The biology of proteostasis in aging and disease
- Pathways of cellular proteostasis in aging and disease
- Aging as an event of proteostasis collapse
- Proteostasis impairment in protein-misfolding and-aggregation diseases
- Quality control of mitochondrial proteostasis
- Proteostasis control by the unfolded protein response
- Proteostasis, oxidative stress and aging
- Molecular chaperones in protein folding and proteostasis
- Proteostasis in cardiac health and disease
- Proteostasis and longevity: when does aging really begin?
- Proteostasis and the aging proteome in health and disease
- Proteostasis impairment in ALS
- FoldEco: a model for proteostasis in E. coli
- Molecular chaperone functions in protein folding and proteostasis
- Cellular proteostasis in neurodegeneration
- Protein folding and mechanisms of proteostasis
- Proteostasis and aging of stem cells
- Walking the tightrope: proteostasis and neurodegenerative disease
- Small-molecule proteostasis regulators for protein conformational diseases
- Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases
- Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity
- Proteostasis in complex dendrites
- Small molecules to improve ER proteostasis in disease
- Insulin regulation of proteostasis and clinical implications
- Proteostasis in endoplasmic reticulum—new mechanisms in kidney disease
- Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging
- The endolysosomal system and proteostasis: from development to degeneration
- Endoplasmic reticulum proteostasis impairment in aging
- Immunoproteasomes are important for proteostasis in immune responses
- Less is more: improving proteostasis by translation slow down
- Shaping proteostasis at the cellular, tissue, and organismal level
- Modeling general proteostasis: proteome balance in health and disease
- A chaperome subnetwork safeguards proteostasis in aging and neurodegenerative disease
- Dysfunction of cellular proteostasis in Parkinson’s disease
- The UFMylation system in proteostasis and beyond
- Chemical and biological approaches for adapting proteostasis to ameliorate protein misfolding and aggregation diseases–progress and prognosis
- The contribution of the 20S proteasome to proteostasis
- The proteostasis boundary in misfolding diseases of membrane traffic
- Diversity in the origins of proteostasis networks—a driver for protein function in evolution
- A ribosomal perspective on proteostasis and aging
- Tailoring of proteostasis networks with heat shock factors
- Role of protein misfolding and proteostasis deficiency in protein misfolding diseases and aging
- Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit
- Extracellular chaperones and proteostasis
- Targeting defective proteostasis in the collagenopathies
- Proteostasis and REDOX state in the heart
- Endoplasmic reticulum proteostasis in hepatic steatosis
- HSF1: guardian of proteostasis in cancer
- Mitochondrial proteostasis in the control of aging and longevity
- The nascent polypeptide‐associated complex is a key regulator of proteostasis
- A cellular perspective on conformational disease: the role of genetic background and proteostasis networks
- A genetic screening strategy identifies novel regulators of the proteostasis network
- Nutrient‐driven O‐GlcNAc in proteostasis and neurodegeneration
- Systemic stress signalling: understanding the cell non-autonomous control of proteostasis
- Molecular chaperones and neuronal proteostasis
- Proteostasis and neurodegeneration: the roles of proteasomal degradation and autophagy
- Regulation of organismal proteostasis by transcellular chaperone signaling
- Stress-independent activation of XBP1s and/or ATF6 reveals three functionally diverse ER proteostasis environments
- Happily (n) ever after: Aging in the context of oxidative stress, proteostasis loss and cellular senescence
- Targeting the proteostasis network in Huntington’s disease
- ER proteostasis control of neuronal physiology and synaptic function
- Proteostasis collapse is a driver of cell aging and death
- Cellular sequestrases maintain basal Hsp70 capacity ensuring balanced proteostasis
- Folding and misfolding of human membrane proteins in health and disease: from single molecules to cellular proteostasis
- Molecular chaperones and proteostasis regulation during redox imbalance
- Perturbed proteostasis in autism spectrum disorders
- Emergent properties of proteostasis in managing cystic fibrosis
- Impaired proteostasis during skeletal muscle aging
- When proteostasis goes bad: protein aggregation in the cell
- MISTERMINATE mechanistically links mitochondrial dysfunction with proteostasis failure
- Distinct proteostasis circuits cooperate in nuclear and cytoplasmic protein quality control
- Proteostasis regulation by the ubiquitin system
- Mitochondrial proteostasis in the context of cellular and organismal health and aging
- Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation
- Critical role of proteostasis-imbalance in pathogenesis of COPD and severe emphysema
- The chemical biology of molecular chaperones—implications for modulation of proteostasis
- Cytosolic proteostasis through importing of misfolded proteins into mitochondria
- Mapping and exploring the collagen-I proteostasis network
- Role of autophagy in proteostasis: friend and foe in cardiac diseases
- Small heat-shock proteins: important players in regulating cellular proteostasis
- Ribosome-associated chaperones as key players in proteostasis
- BAG3-mediated proteostasis at a glance
- CCPG1 is a non-canonical autophagy cargo receptor essential for ER-phagy and pancreatic ER proteostasis
- TFEB regulates lysosomal proteostasis
- Modulation of proteostasis by transcription factor NRF2 and impact in neurodegenerative diseases
- Malfolded protein structure and proteostasis in lung diseases
- Hyperammonemia and proteostasis in cirrhosis
- Neuroendocrine coordination of mitochondrial stress signaling and proteostasis
- Presenilins and γ-secretase in membrane proteostasis
- Proteostasis of polyglutamine varies among neurons and predicts neurodegeneration
- Cytosolic proteostasis networks of the mitochondrial stress response
- The ER proteostasis network in ALS: Determining the differential motoneuron vulnerability
- Long-lived species have improved proteostasis compared to phylogenetically-related shorter-lived species
- Embryonic stem cells: a novel paradigm to study proteostasis?
- The effects of proteasomal inhibition on synaptic proteostasis
- Loss of hepatic chaperone‐mediated autophagy accelerates proteostasis failure in aging
- Proteostasis disturbance in amyotrophic lateral sclerosis
- FOXO/4E-BP signaling in Drosophila muscles regulates organism-wide proteostasis during aging
- Regulating secretory proteostasis through the unfolded protein response: from function to therapy
- The pathophysiology of defective proteostasis in the hypothalamus—from obesity to ageing
- Cross talk of proteostasis and mitostasis in cellular homeodynamics, ageing, and disease
- The rise of proteostasis promoters
- Endoplasmic reticulum proteostasis: a key checkpoint in cancer
- Targeting mitochondrial function and proteostasis to mitigate dynapenia
- Gene therapy strategies to restore ER proteostasis in disease
- APP metabolism regulates tau proteostasis in human cerebral cortex neurons
- Proteostasis of huntingtin in health and disease
- Redox regulation of homeostasis and proteostasis in peroxisomes
- Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis
- Targeting the proteostasis network for mycobacterial drug discovery
- Mitochondrial stress restores the heat shock response and prevents proteostasis collapse during aging
- Proteostasis in the endoplasmic reticulum: road to cure
- Proteostasis and beyond: ATF6 in ischemic disease
- Control of systemic proteostasis by the nervous system
- Impaired PSII proteostasis triggers a UPR-like response in the var2 mutant of Arabidopsis
- Ubiquitin-dependent and independent roles of SUMO in proteostasis
- The stop-and-go traffic regulating protein biogenesis: How translation kinetics controls proteostasis
- Age-related oxidative stress compromises endosomal proteostasis
- Loss of proteostasis is a pathomechanism in Cockayne syndrome
- Impaired proteostasis: role in the pathogenesis of diabetes mellitus
- Autophagy and proteostasis in the control of synapse aging and disease
- Cellular proteostasis: degradation of misfolded proteins by lysosomes
- Bacterial proteostasis balances energy and chaperone utilization efficiently
- Proteostasis in Huntington’s disease: disease mechanisms and therapeutic opportunities
- Host proteostasis modulates influenza evolution
- ER proteostasis addiction in cancer biology: Novel concepts
- Using pharmacological chaperones to restore proteostasis
- A thiol probe for measuring unfolded protein load and proteostasis in cells
- Impaired proteostasis in rare neurological diseases
- The autophagy-lysosomal pathways and their emerging roles in modulating proteostasis in tumors
- The role of co-chaperones in synaptic proteostasis and neurodegenerative disease
- A lysosomal switch triggers proteostasis renewal in the immortal C. elegans germ lineage
- Proteostasis during cerebral ischemia
- The measurement of protein synthesis for assessing proteostasis in studies of slowed aging
- Proteostasis: a new therapeutic paradigm for pulmonary disease
- Unfolded protein response‐induced ER dj3 secretion links ER stress to extracellular proteostasis
- Organismal proteostasis: role of cell-nonautonomous regulation and transcellular chaperone signaling
- Proteostasis regulation at the endoplasmic reticulum: a new perturbation site for targeted cancer therapy
- The structure of the PA28–20S proteasome complex from Plasmodium falciparum and implications for proteostasis
- Systematic proteome and proteostasis profiling in human Trisomy 21 fibroblast cells
- Aging and proteins: what does proteostasis have to do with age?
- Activation of the endoplasmic reticulum unfolded protein response by lipid disequilibrium without disturbed proteostasis in vivo
- Mechanisms of cellular proteostasis: insights from single-molecule approaches
- Impact of high hydrostatic pressure on bacterial proteostasis
- Proteasome dysfunction in Drosophila signals to an Nrf2‐dependent regulatory circuit aiming to restore proteostasis and prevent premature aging
- Structures and functions of protein disulfide isomerase family members involved in proteostasis in the endoplasmic reticulum
- mTORC1 senses stresses: Coupling stress to proteostasis
- The proteostasis network provides targets for neurodegeneration
- Discovery proteomics in aging human skeletal muscle finds change in spliceosome, immunity, proteostasis and mitochondria
- Proteostasis and ageing: insights from long‐lived mutant mice
- Proteostasis and movement disorders: Parkinson’s disease and amyotrophic lateral sclerosis
- sHSP in the eye lens: crystallin mutations, cataract and proteostasis
- Hspb7 is a cardioprotective chaperone facilitating sarcomeric proteostasis
- An intracellular pathogen response pathway promotes proteostasis in C. elegans
- Biological and structural basis for Aha1 regulation of Hsp90 ATPase activity in maintaining proteostasis in the human disease cystic fibrosis
- Impact of tRNA modifications and tRNA-modifying enzymes on proteostasis and human disease
- Cerebral amyloid-β proteostasis is regulated by the membrane transport protein ABCC1 in mice
- Aberrant proteostasis of BMAL1 underlies circadian abnormalities in a paradigmatic mTOR-opathy
- Dietary restriction improves proteostasis and increases life span through endoplasmic reticulum hormesis
- Hypoxia disrupts proteostasis in Caenorhabditis elegans
- Role of mTORC1 controlling proteostasis after brain ischemia
- NMNAT2: HSP90 complex mediates proteostasis in proteinopathies
- Proteostasis of tau. Tau overexpression results in its secretion via membrane vesicles
- The RAB GTPase RAB18 modulates macroautophagy and proteostasis
- Mutant huntingtin disrupts mitochondrial proteostasis by interacting with TIM23
- Activin Signaling Targeted by Insulin/dFOXO Regulates Aging and Muscle Proteostasis in Drosophila
- Proteostasis in the Hedgehog signaling pathway
- Innovative strategies to treat protein misfolding in inborn errors of metabolism: pharmacological chaperones and proteostasis regulators
- Coupling of ribostasis and proteostasis: Hsp70 proteins in mRNA metabolism
- Mechanisms of protein homeostasis (proteostasis) maintain stem cell identity in mammalian pluripotent stem cells
- Defining the essential function of yeast Hsf1 reveals a compact transcriptional program for maintaining eukaryotic proteostasis
- Ammonia lowering reverses sarcopenia of cirrhosis by restoring skeletal muscle proteostasis
- Keeping up the balance: role of HDACs in cardiac proteostasis and therapeutic implications for atrial fibrillation
- Germline stem cell arrest inhibits the collapse of somatic proteostasis early in Caenorhabditis elegans adulthood
- Targeting viral proteostasis limits influenza virus, HIV, and dengue virus infection
- Expanding the organismal proteostasis network: Linking systemic stress signaling with the innate immune response
- A Screenable in vivo Assay to Study Proteostasis Networks in Caenorhabditis elegans
- Defective proteostasis in celiac disease as a new therapeutic target
- Therapeutic strategies to correct proteostasis-imbalance in chronic obstructive lung diseases
- Mitochondrial DNA polymorphisms specifically modify cerebral β-amyloid proteostasis
- Resveratrol induces brain resilience against Alzheimer neurodegeneration through proteostasis enhancement
- The unfolded protein response and proteostasis in Alzheimer disease: preferential activation of autophagy by endoplasmic reticulum stress
- A critical appraisal of quantitative studies of protein degradation in the framework of cellular proteostasis
- Prions, chaperones, and proteostasis in yeast
- Aggregating sequences that occur in many proteins constitute weak spots of bacterial proteostasis
- Impairment of proteostasis network in Down syndrome prior to the development of Alzheimer’s disease neuropathology: redox proteomics analysis of human …
- Deconvoluting stress-responsive proteostasis signaling pathways for pharmacologic activation using targeted RNA sequencing
- Mitophagy in maintaining skeletal muscle mitochondrial proteostasis and metabolic health with ageing
- A biosensor-based framework to measure latent proteostasis capacity
- Proteostasis, an emerging therapeutic paradigm for managing inflammatory airway stress disease
- Progressing neurobiological strategies against proteostasis failure: Challenges in neurodegeneration
- To adapt or not to adapt: consequences of declining adaptive homeostasis and proteostasis with age
- Fluorodeoxyuridine Improves Caenorhabditis elegans Proteostasis Independent of Reproduction Onset
- Manipulating proteostasis to repair the F508del-CFTR defect in cystic fibrosis
- Rbfox splicing factors maintain skeletal muscle mass by regulating calpain3 and proteostasis
- The STI and UBA domains of UBQLN1 are critical determinants of substrate interaction and proteostasis
- Age-related changes in the proteostasis network in the brain of the naked mole-rat: implications promoting healthy longevity
- Heat shock protein–inducing compounds as therapeutics to restore Proteostasis in atrial fibrillation
- Flagging and docking: dual roles for N-glycans in protein quality control and cellular proteostasis
- Expanding proteostasis by membrane trafficking networks
- Dynamic ubiquitylation of Sox2 regulates proteostasis and governs neural progenitor cell differentiation
- ER proteostasis disturbances in Parkinson’s disease: novel insights
- Role of nerve–muscle interactions and reactive oxygen species in regulation of muscle proteostasis with ageing
- Chaperone proteostasis in Parkinson’s disease: Stabilization of the Hsp70/α‐synuclein complex by Hip
- PRMT5 modulates splicing for genome integrity and preserves proteostasis of hematopoietic stem cells
- The ubiquitin ligase CHIP integrates proteostasis and aging by regulation of insulin receptor turnover
- Loss of the proteostasis factor AIRAPL causes myeloid transformation by deregulating IGF-1 signaling
- Uncoupling proteostasis and development in vitro with a small molecule inhibitor of the pancreatic endoplasmic reticulum kinase, PERK
- FOXO3 directly regulates an autophagy network to functionally regulate proteostasis in adult neural stem cells
- Proteostasis and “redoxtasis” in the secretory pathway: tales of tails from ERp44 and immunoglobulins
- Inflammasome activation by altered proteostasis
- Cellular proteostasis during influenza A virus infection—friend or foe?
- Pharmaceutical chaperones and proteostasis regulators in the therapy of lysosomal storage disorders: current perspective and future promises
- Adapting proteostasis and autophagy for controlling the pathogenesis of cystic fibrosis lung disease
- Sphingolipid modulation activates proteostasis programs to govern human hematopoietic stem cell self-renewal
- Palmitoylation enables MAPK-dependent proteostasis of axon survival factors
- ErbB2 regulates autophagic flux to modulate the proteostasis of APP-CTFs in Alzheimer’s disease
- Mitochondrial proteostasis as a shared characteristic of slowed aging: the importance of considering cell proliferation
- Translation attenuation by minocycline enhances longevity and proteostasis in old post-stress-responsive organisms
- The ubiquitin ligase UBR5 suppresses proteostasis collapse in pluripotent stem cells from Huntington’s disease patients
- Proteostasis by STUB1/HSP70 complex controls sensitivity to androgen receptor targeted therapy in advanced prostate cancer
- Altered proteostasis in aging and heat shock response in C. elegans revealed by analysis of the global and de novo synthesized proteome
- Endoplasmic reticulum proteostasis control and gastric cancer
- Olfaction regulates organismal proteostasis and longevity via microRNA-dependent signalling
- Linking cellular proteostasis to yeast longevity
- Disease-relevant proteostasis regulation of cystic fibrosis transmembrane conductance regulator
- Non-enzymatic post-translational protein modifications and proteostasis network deregulation in carcinogenesis
- Mevalonate pathway regulates cell size homeostasis and proteostasis through autophagy
- Proteostasis and ALS: protocol for a phase II, randomised, double-blind, placebo-controlled, multicentre clinical trial for colchicine in ALS (Co-ALS)
- Adapt, recycle, and move on: proteostasis and trafficking mechanisms in melanoma
- Immunoproteasome inhibition impairs T and B cell activation by restraining ERK signaling and proteostasis
- Somatic increase of CCT8 mimics proteostasis of human pluripotent stem cells and extends C. elegans lifespan
- Proteasome‐mediated proteostasis: Novel medicinal and pharmacological strategies for diseases
- Proteostasis and mitochondrial role on psychiatric and neurodegenerative disorders: current perspectives
- Proteostasis in cerebral small vessel disease
- Selenoprotein T is a key player in ER proteostasis, endocrine homeostasis and neuroprotection
- Celastrol targets proteostasis and acts synergistically with a heat-shock protein 90 inhibitor to kill human glioblastoma cells
- JNK modifies neuronal metabolism to promote proteostasis and longevity
- SUMOylation and the HSF1-regulated chaperone network converge to promote proteostasis in response to heat shock
- A homeostatic shift facilitates endoplasmic reticulum proteostasis through transcriptional integration of proteostatic stress response pathways
- Age-related proteostasis and metabolic alterations in Caspase-2-deficient mice
- CCPG1, a cargo receptor required for reticulophagy and endoplasmic reticulum proteostasis
- Spindle assembly checkpoint robustness requires Tpr-mediated regulation of Mad1/Mad2 proteostasis
- Nrf2 mitigates LRRK2-and α-synuclein–induced neurodegeneration by modulating proteostasis
- Clp protease and OR directly control the proteostasis of phytoene synthase, the crucial enzyme for carotenoid biosynthesis in Arabidopsis
- Conditional protein function via N-degron pathway–mediated proteostasis in stress physiology
- Spatial quality control bypasses cell-based limitations on proteostasis to promote prion curing
- Chaperone-assisted proteostasis is essential for mechanotransduction in mammalian cells
- Fatty acid and lipopolysaccharide effect on beta cells proteostasis and its impact on insulin secretion
- Protein aggregates and proteostasis in aging: amylin and β-cell function
- The nucleolus as a proteostasis regulator
- Regulating extracellular proteostasis capacity through the unfolded protein response
- Proteostasis and RNA binding proteins in synaptic plasticity and in the pathogenesis of neuropsychiatric disorders
- Proteome dynamics: tissue variation in the kinetics of proteostasis in intact animals
- p53 is a master regulator of proteostasis in SMARCB1-deficient malignant rhabdoid tumors
- A plastic SQSTM1/p62-dependent autophagic reserve maintains proteostasis and determines proteasome inhibitor susceptibility in multiple myeloma cells
- mTOR/AMPK signaling in the brain: Cell metabolism, proteostasis and survival
- The chaperonin TRiC/CCT associates with prefoldin through a conserved electrostatic interface essential for cellular proteostasis
- A non-BRICHOS SFTPC mutant (SP-CI73T) linked to interstitial lung disease promotes a late block in macroautophagy disrupting cellular proteostasis and …
- A Differentiation Transcription Factor Establishes Muscle-Specific Proteostasis in Caenorhabditis elegans
- Proteostasis modulators prolong missense VHL protein activity and halt tumor progression
- Gold nanourchins induce cellular stress, impair proteostasis and damage RNA
- Gambogic acid triggers vacuolization-associated cell death in cancer cells via disruption of thiol proteostasis
- Maintenance of proteostasis by P body-mediated regulation of eIF4E availability during aging in Caenorhabditis elegans
- Inhibition of stress-inducible HSP70 impairs mitochondrial proteostasis and function
- Vulnerability of newly synthesized proteins to proteostasis stress
- MitoCPR: Meticulous monitoring of mitochondrial proteostasis
- Improved proteostasis in the secretory pathway rescues Alzheimer’s disease in the mouse
- A new Drosophila model of Ubiquilin knockdown shows the effect of impaired proteostasis on locomotive and learning abilities
- Exercise prevents impaired autophagy and proteostasis in a model of neurogenic myopathy
- Proteostasis in striatal cells and selective neurodegeneration in Huntington’s disease
- Proteostasis environment shapes higher-order epistasis operating on antibiotic resistance
- A quantitative and temporal map of proteostasis during heat shock in Saccharomyces cerevisiae
- Proteostasis and the regulation of intra-and extracellular protein aggregation by ATP-independent molecular chaperones: lens α-crystallins and milk caseins
- Proteostasis in pediatric pulmonary pathology
- SMPD3 deficiency perturbs neuronal proteostasis and causes progressive cognitive impairment
- Oxidative stress, mitochondrial and proteostasis malfunction in adrenoleukodystrophy: a paradigm for axonal degeneration
- J protein mutations and resulting proteostasis collapse
- Proteostasis collapse, a hallmark of aging, hinders the chaperone-Start network and arrests cells in G1
- Variable repeats in the eukaryotic polyubiquitin gene ubi4 modulate proteostasis and stress survival
- Protein folding and the challenges of maintaining endoplasmic reticulum proteostasis in idiopathic pulmonary fibrosis
- Unravelling druggable signalling networks that control F508del-CFTR proteostasis
- The ribosome-bound quality control complex: from aberrant peptide clearance to proteostasis maintenance
- Unraveling the structure and dynamics of the human DNAJB6b chaperone by NMR reveals insights into Hsp40-mediated proteostasis
- Amelioration of mitochondrial quality control and proteostasis by natural compounds in Parkinson’s disease models
- Oxidative stress and proteostasis network: culprit and casualty of Alzheimer’s-like neurodegeneration
- Vps34 regulates myofibril proteostasis to prevent hypertrophic cardiomyopathy
- HSF1 stress response pathway regulates autophagy receptor SQSTM1/p62-associated proteostasis
- Thermal Shock Induces Host Proteostasis Disruption and Endoplasmic Reticulum Stress in the Model Symbiotic Cnidarian Aiptasia
- KPNB1 inhibition disrupts proteostasis and triggers unfolded protein response-mediated apoptosis in glioblastoma cells
- Repair or destruction—an intimate liaison between ubiquitin ligases and molecular chaperones in proteostasis
- Impaired PSII proteostasis promotes retrograde signaling via salicylic acid
- Loss of proteostasis induced by amyloid beta peptide in brain endothelial cells
- Adapting secretory proteostasis and function through the unfolded protein response
- Prion proteostasis: Hsp104 meets its supporting cast
- UCHL3 regulates topoisomerase-induced chromosomal break repair by controlling TDP1 proteostasis
- Osmotic stress–induced defective glial proteostasis contributes to brain demyelination after hyponatremia treatment
- Epigenetic inheritance of proteostasis and ageing
- A PRMT5-RNF168-SMURF2 Axis Controls H2AX Proteostasis
- Lipid assemblies at the crossroads of aging, proteostasis, and neurodegeneration
- Tau protein aggregates inhibit the protein-folding and vesicular trafficking arms of the cellular proteostasis network
- PROTEOSTASIS: A European network to break barriers and integrate science on protein homeostasis
- Physiology and pathology of proteostasis in the early secretory compartment
- Caenorhabditis elegans as a model system to study intercompartmental proteostasis: Interrelation of mitochondrial function, longevity, and neurodegenerative …
- Combination of correctors rescues CFTR transmembrane-domain mutants by mitigating their interactions with proteostasis
- The function of small heat-shock proteins and their implication in proteostasis
- Titanium dioxide nanoparticles induce proteostasis disruption and autophagy in human trophoblast cells
- Intracellular crowding by age-dependent neuromelanin accumulation disrupts neuronal proteostasis and triggers Parkinson disease pathology
- Proteostasis: bad news and good news from the endoplasmic reticulum
- Partial failure of proteostasis systems counteracting TDP-43 aggregates in neurodegenerative diseases
- Early-age-related changes in proteostasis augment immunopathogenesis of sepsis and acute lung injury
- HSP60-regulated mitochondrial proteostasis and protein translation promote tumor growth of ovarian cancer
- Peroxisomal proteostasis involves a Lon family protein that functions as protease and chaperone
- Nε-lysine acetylation in the endoplasmic reticulum–a novel cellular mechanism that regulates proteostasis and autophagy
- SAHA enhances proteostasis of epilepsy-associated α1 (A322D) β2γ2 GABAA receptors
- Natural products as modulators of the proteostasis machinery: implications in neurodegenerative diseases
- Induction of the immunoproteasome subunit Lmp7 links proteostasis and immunity in α-synuclein aggregation disorders
- Diet-derived advanced glycation end products or lipofuscin disrupts proteostasis and reduces life span in Drosophila melanogaster
- A novel pulse-chase SILAC strategy measures changes in protein decay and synthesis rates induced by perturbation of proteostasis with an Hsp90 inhibitor
- Create and preserve: proteostasis in development and aging is governed by Cdc48/p97/VCP
- Expression of FSHD‐related DUX4‐FL alters proteostasis and induces TDP‐43 aggregation
- PERK signaling regulates extracellular proteostasis of an amyloidogenic protein during endoplasmic reticulum stress
- Changes in the turnover of the cellular proteome during metabolic reprogramming: A role for mtROS in proteostasis
- Impaired capacity to restore proteostasis in the aged brain after ischemia: Implications for translational brain ischemia research
- Defective collagen proteostasis and matrix formation in the pathogenesis of lysosomal storage disorders
- Compensatory increases of select proteostasis networks after Hsp70 inhibition in cancer cells
- Interrelation between protein synthesis, proteostasis and life span
- Emergent properties of proteostasis-COPII coupled systems in human health and disease
- On the relationship between energy metabolism, proteostasis, aging and Parkinson’s disease: possible causative role of methylglyoxal and alleviative …
- Cigarette smoke-induced proteostasis imbalance in obstructive lung diseases
- Plastid proteostasis and heterologous protein accumulation in transplastomic plants
- Aging attenuates redox adaptive homeostasis and proteostasis in female mice exposed to traffic-derived nanoparticles (‘vehicular smog’)
- Downregulation of HSP60 disrupts mitochondrial proteostasis to promote tumorigenesis and progression in clear cell renal cell carcinoma
- Repurposing proteostasis-modifying drugs to prevent or treat age-related dementia: a systematic review
- Loss of glutathione redox homeostasis impairs proteostasis by inhibiting autophagy-dependent protein degradation
- Type ii epithelial-mesenchymal transition upregulates protein n-glycosylation to maintain proteostasis and extracellular matrix production
- Roles of the nucleotide exchange factor and chaperone Hsp110 in cellular proteostasis and diseases of protein misfolding
- The mevalonate pathway as a metabolic requirement for autophagy–implications for growth control, proteostasis, and disease
- Role of the Nervous System in the Control of Proteostasis during Innate Immune Activation: Insights from C. elegans
- Proteostasis Strategies for Restoring α1-Antitrypsin Deficiency
- Regulation of cell-non-autonomous proteostasis in metazoans
- Derailed proteostasis as a determinant of cardiac aging
- Mediation of organismal aging and somatic proteostasis by the germline
- Critical roles of dual-specificity phosphatases in neuronal proteostasis and neurological diseases
- HDAC6 suppresses age-dependent ectopic fat accumulation by maintaining the proteostasis of PLIN2 in Drosophila
- Proteostasis regulators and pharmacologic chaperones synergize to correct protein misfolding diseases
- The role of Yca1 in proteostasis. Yca1 regulates the composition of the insoluble proteome
- Drug repurposing to target proteostasis and prevent neurodegeneration: accelerating translational efforts
- Remodeling the endoplasmic reticulum proteostasis network restores proteostasis of pathogenic GABAA receptors
- Remodeling of proteostasis upon transition to adulthood is linked to reproduction onset
- Caloric restriction induces microRNAs to improve mitochondrial proteostasis
- CYLD regulates centriolar satellites proteostasis by counteracting the E3 ligase MIB1
- Mitochondrial matrix proteostasis is linked to hereditary paraganglioma: LON‐mediated turnover of the human flavinylation factor SDH5 is regulated by its interaction …
- Insulin/IGF1 signalling mediates the effects of β2‐adrenergic agonist on muscle proteostasis and growth
- Gp78 E3 ubiquitin ligase: essential functions and contributions in proteostasis
- Proteostasis is essential during cochlear development for neuron survival and hair cell polarity
- Candidate-based screening via gene modulation in human neurons and astrocytes implicates FERMT2 in Aβ and TAU proteostasis
- Reconstitution of a Mycobacterium tuberculosis proteostasis network highlights essential cofactor interactions with chaperone DnaK
- BAG3 plays a central role in proteostasis in the heart
- Curcumin improves palmitate-induced insulin resistance in human umbilical vein endothelial cells by maintaining proteostasis in endoplasmic reticulum
- Pharmaceutical inhibition of mTOR in the common marmoset: effect of rapamycin on regulators of proteostasis in a non-human primate
- An engineered, quantifiable in vitro model for analysing the effect of proteostasis-targeting drugs on tissue physical properties
- Modest overexpression of FOXO maintains cardiac proteostasis and ameliorates age‐associated functional decline
- The struggle by Caenorhabditis elegans to maintain proteostasis during aging and disease
- Novel α-tubulin mutation disrupts neural development and tubulin proteostasis
- dFOXO activates large and small heat shock protein genes in response to oxidative stress to maintain proteostasis in Drosophila
- ATP13A2/PARK9 regulates endo-/lysosomal cargo sorting and proteostasis through a novel PI (3, 5) P2-mediated scaffolding function
- Assembly of proteins by free RNA during the early phase of proteostasis stress
- Nuclear inclusion bodies of mutant and wild‐type p53 in cancer: a hallmark of p53 inactivation and proteostasis remodelling by p53 aggregation
- The Plastid and Mitochondrial Peptidase Network in Arabidopsis thaliana: A Foundation for Testing Genetic Interactions and Functions in Organellar Proteostasis
- CHIP as a membrane-shuttling proteostasis sensor
- Role of altered proteostasis network in chronic hypobaric hypoxia induced skeletal muscle atrophy
- Mechanisms of L-serine neuroprotection in vitro include er proteostasis regulation
- The coordinated action of VCP/p97 and GCN2 regulates cancer cell metabolism and proteostasis during nutrient limitation
- Oxidative protein modification alters proteostasis under acute hypobaric hypoxia in skeletal muscles: a comprehensive in vivo study
- Genome-wide RNAi screen for fat regulatory genes in C. elegans identifies a proteostasis-AMPK axis critical for starvation survival
- SAGA DUBm-mediated surveillance regulates prompt export of stress-inducible transcripts for proteostasis
- Loss of Ranbp2 in motoneurons causes disruption of nucleocytoplasmic and chemokine signaling, proteostasis of hnRNPH3 and Mmp28, and development of …
- Longitudinal measures of proteostasis in live neurons: features that determine fate in models of neurodegenerative disease
- Exosomes and STUB1/CHIP cooperate to maintain intracellular proteostasis
- Global and local mechanisms sustain axonal proteostasis of transmembrane proteins
- Lipid disequilibrium disrupts ER proteostasis by impairing ERAD substrate glycan trimming and dislocation
- Aqueous extracts of Paeonia suffruticosa modulates mitochondrial proteostasis by reactive oxygen species-induced endoplasmic reticulum stress in pancreatic cancer …
- Loss of the novel Vcp (valosin containing protein) interactor Washc4 interferes with autophagy-mediated proteostasis in striated muscle and leads to myopathy in vivo
- ER strikes again: proteostasis dysfunction in ALS
- Characterization of the Proteostasis Roles of Glycerol Accumulation, Protein Degradation and Protein Synthesis during Osmotic Stress in C. elegans
- Ophiobolin A kills human glioblastoma cells by inducing endoplasmic reticulum stress via disruption of thiol proteostasis
- VAMP-associated proteins (VAP) as receptors that couple cystic fibrosis transmembrane conductance regulator (CFTR) proteostasis with lipid homeostasis
- PPARGC1A/PGC-1α, TFEB and enhanced proteostasis in Huntington disease: Defining regulatory linkages between energy production and protein–organelle quality …
- Roscovitine is a proteostasis regulator that corrects the trafficking defect of F 508del‐CFTR by a CDK‐independent mechanism
- DEG10 contributes to mitochondrial proteostasis, root growth, and seed yield in Arabidopsis
- Polylysine is a proteostasis network-engaging structural determinant
- Integrative quantitative proteomics unveils proteostasis imbalance in human hepatocellular carcinoma developed on nonfibrotic livers
- Proteostasis and SUMO in the heart
- Proteasome β5 subunit overexpression improves proteostasis during aging and extends lifespan in Drosophila melanogaster
- Ca2+ Homeostasis Modulation Enhances the Amenability of L444P Glucosylcerebrosidase to Proteostasis Regulation in Patient-Derived Fibroblasts
- Ryanodine receptor antagonists adapt NPC1 proteostasis to ameliorate lipid storage in Niemann–Pick type C disease fibroblasts
- iTRAQ-based analysis of progerin expression reveals mitochondrial dysfunction, reactive oxygen species accumulation and altered proteostasis
- Control of anterior GR adient 2 (AGR 2) dimerization links endoplasmic reticulum proteostasis to inflammation
- Restoration of Proteostasis in the Endoplasmic Reticulum Reverses an Inflammation-Like Response to Cytoplasmic DNA in Caenorhabditis elegans
- Compromised mutant EFEMP1 secretion associated with macular dystrophy remedied by proteostasis network alteration
- Cranberry Extract Standardized for Proanthocyanidins Alleviates β-Amyloid Peptide Toxicity by Improving Proteostasis Through HSF-1 in Caenorhabditis elegans …
- Selective inhibition of a regulatory subunit of protein phosphatase 1 restores proteostasis
- In Vivo Interaction Proteomics Reveal a Novel p38 Mitogen-Activated Protein Kinase/Rack1 Pathway Regulating Proteostasis in Drosophila Muscle
- The metacaspase Yca1 maintains proteostasis through multiple interactions with the ubiquitin system
- Enhanced ER proteostasis and temperature differentially impact the mutational tolerance of influenza hemagglutinin
- Endoplasmic reticulum proteostasis influences the oligomeric state of an amyloidogenic protein secreted from mammalian cells
- Recurrent background mutations in WHI2 impair proteostasis and degradation of misfolded cytosolic proteins in Saccharomyces cerevisiae
- Altered organization of the intermediate filament cytoskeleton and relocalization of proteostasis modulators in cells lacking the ataxia protein sacsin
- A Novel mouse model of enhanced proteostasis: Full-length human heat shock factor 1 transgenic mice
- Targeting proteostasis and autophagy in SMARCB1-deficient malignancies: where next?
- NFκB mitigates the pathological effects of misfolded α1-antitrypsin by activating autophagy and an integrated program of proteostasis mechanisms
- Differential roles of the thylakoid lumenal Deg protease homologs in chloroplast proteostasis
- Molecular chaperones: from proteostasis to pathogenesis
- 2D DIGE based proteomics study of erythrocyte cytosol in sickle cell disease: altered proteostasis and oxidative stress
- Proteostasis network deregulation signatures as biomarkers for pharmacological disease intervention
- Aggregation of human S100A8 and S100A9 amyloidogenic proteins perturbs proteostasis in a yeast model
- Aqueous extract of Polygonum bistorta modulates proteostasis by ROS-induced ER stress in human hepatoma cells
- Remodeling the proteostasis network to rescue glucocerebrosidase variants by inhibiting ER-associated degradation and enhancing ER folding
- Special Issue on “Proteostasis and Autophagy”
- Modulating proteostasis: peptidomimetic inhibitors and activators of protein folding
- Modulation of protein synthesis and degradation maintains proteostasis during yeast growth at different temperatures
- Review and literature mining on proteostasis factors and cancer
- Resveratrol attenuates copper-induced senescence by improving cellular proteostasis
- Phosphorylation dependent proteostasis of sterol regulatory element binding proteins
- Neuroinflammation alters cellular proteostasis by producing endoplasmic reticulum stress, autophagy activation and disrupting ERAD activation
- Neuroinflammation and proteostasis are modulated by endogenously biosynthesized neuroprotectin D1
- Balancing the Photoreceptor proteome: proteostasis network therapeutics for inherited retinal disease
- Molecular targets for modulating the protein translation vital to proteostasis and neuron degeneration in Parkinson’s disease
- Hyperactivation of the insulin signaling pathway improves intracellular proteostasis by coordinately up-regulating the proteostatic machinery in adipocytes
- Overexpression of pink1 or parkin in indirect flight muscles promotes mitochondrial proteostasis and extends lifespan in Drosophila melanogaster
- FKBP10 depletion enhances glucocerebrosidase proteostasis in Gaucher disease fibroblasts
- Proteostasis as a therapeutic target in glomerular injury associated with mutant α-actinin-4
- Multiple myeloma proteostasis can be targeted via translation initiation factor eIF4E
- Manipulating proteostasis
- The autophagy receptor p62/SQST-1 promotes proteostasis and longevity in C. elegans by inducing autophagy
- Enhanced proteostasis in post-ischemic stroke mouse brains by ubiquilin-1 promotes functional recovery
- Molecular chaperones as therapeutic targets to counteract proteostasis defects
- Failed mitochondrial import and impaired proteostasis trigger SUMOylation of mitochondrial proteins
- Dendrimer-based selective proteostasis-inhibition strategy to control NSCLC growth and progression
- Possible mechanisms by which stefin B could regulate proteostasis and oxidative stress
- Modulation of the Proteostasis Machinery to Overcome Stress Caused by Diminished Levels of t6A‐Modified tRNAs in Drosophila
- Toxicant-mediated redox control of proteostasis in neurodegeneration
- Sigma-1 receptor activation induces autophagy and increases proteostasis capacity in vitro and in vivo
- Coffee extract and caffeine enhance the heat shock response and promote proteostasis in an HSF-1-dependent manner in Caenorhabditis elegans
- (Poly) phenol-digested metabolites modulate alpha-synuclein toxicity by regulating proteostasis
- Quantitative proteomics of rat livers shows that unrestricted feeding is stressful for proteostasis with implications on life span
- The therapeutic effects of 4-phenylbutyric acid in maintaining proteostasis
- Alpha-fetoprotein is a biomarker of unfolded protein response and altered proteostasis in hepatocellular carcinoma cells exposed to sorafenib
- Resveratrol reduces amyloid-beta (Aβ1–42)-induced paralysis through targeting proteostasis in an Alzheimer model of Caenorhabditis elegans
- CCPG1 is a noncanonical autophagy cargo receptor essential for reticulophagy and pancreatic ER proteostasis
- Sorting out how Msp1 maintains mitochondrial membrane proteostasis
- Activation of histone deacetylase-6 induces contractile dysfunction through derailment of α-tubulin proteostasis in experimental and human atrial fibrillation
- Heat shock factor 2 is required for maintaining proteostasis against febrile-range thermal stress and polyglutamine aggregation
- Hormetic heat stress and HSF-1 induce autophagy to improve survival and proteostasis in C. elegans
- TRNA mutations that affect decoding fidelity deregulate development and the proteostasis network in zebrafish
- Proteostasis maintenance of Cys-loop receptors
- Neuronal XBP-1 activates intestinal lysosomes to improve proteostasis in C. elegans
- SIL1, the endoplasmic-reticulum-localized BiP co-chaperone, plays a crucial role in maintaining skeletal muscle proteostasis and physiology
- Anti-prion Protein Antibody 6D11 Restores Cellular Proteostasis of Prion Protein Through Disrupting Recycling Propagation of PrP Sc and Targeting PrP Sc for …
- Agents that stabilize mutated von Hippel–Lindau (VHL) protein: results of a high-throughput screen to identify compounds that modulate VHL proteostasis
- Proteostasis takes center stage in pulmonary fibrosis
- How is proteinuric diabetic nephropathy caused by disturbed proteostasis and autophagy in podocytes?
- The burden of trisomy 21 disrupts the proteostasis network in Down syndrome
- Phosphorylation-dependent cleavage regulates von Hippel Lindau proteostasis and function
- Blocking TGF-β signaling pathway preserves mitochondrial proteostasis and reduces early activation of PDGFRβ+ pericytes in aristolochic acid induced acute …
- Insulin and IGF-1 receptors regulate FoxO-mediated signaling in muscle proteostasis
- Cross‐compartment proteostasis regulation during redox imbalance induced ER stress
- Worming our way to novel drug discovery with the Caenorhabditis elegans proteostasis network, stress response and insulin-signaling pathways
- Thermophilic adaptation in prokaryotes is constrained by metabolic costs of proteostasis
- Proteomic analysis of eIF5B silencing-modulated proteostasis
- The case for therapeutic proteostasis modulators
- Combined inhibition of Hsp90 and the proteasome affects NSCLC proteostasis and attenuates cell migration
- The insulin/IGF signaling cascade modulates SUMOylation to regulate aging and proteostasis in Caenorhabditis elegans
- Caloric restriction rescues yeast cells from alpha-synuclein toxicity through autophagic control of proteostasis
- Absence of collagen XVIII in mice causes age-related insufficiency in retinal pigment epithelium proteostasis
- Overview: the modulation of ageing through altered proteostasis
- P97/CDC-48: proteostasis control in tumor cell biology
- Novel modulators of proteostasis: RNAi screen of chromosome I in a heat stress paradigm in C. elegans
- Cross-species functional modules link proteostasis to human normal aging
- Can correcting the ΔF508-CFTR proteostasis-defect rescue CF lung disease?
- The Machado-Joseph disease deubiquitylase ATX-3 couples longevity and proteostasis
- A chemical genetic screen reveals a role for proteostasis in capsule and biofilm formation by Cryptococcus neoformans
- Healthy ageing through regulated proteostasis
- Effect of oxygen tension on bioenergetics and proteostasis in young and old myoblast precursor cells
- Modulation of proteostasis counteracts oxidative stress and affects DNA base excision repair capacity in ATM-deficient cells
- New roles for OMA1 metalloprotease: From mitochondrial proteostasis to metabolic homeostasis
- Endoplasmic reticulum Ca 2+ increases enhance mutant glucocerebrosidase proteostasis
- Dietary-induced signals that activate the gonadal longevity pathway during development regulate a proteostasis switch in Caenorhabditis elegans adulthood
- A PQM-1-mediated response triggers transcellular chaperone signaling and regulates organismal proteostasis
- SerpinB2 (PAI-2) modulates proteostasis via binding misfolded proteins and promotion of cytoprotective inclusion formation
- Perturbation of cellular proteostasis networks identifies pathways that modulate precursor and intermediate but not mature levels of frataxin
- MDT-15/MED15 permits longevity at low temperature via enhancing lipidostasis and proteostasis
- Proteostasis collapse, inter-tissue communication, and the regulation of aging at the organismal level
- Targeting the angio-proteostasis network: Combining the forces against cancer
- The intrinsic and extrinsic factors that contribute to proteostasis decline and pathological protein misfolding
- Cellular proteostasis: a new twist in the action of thymosin α1
- Fasting prevents hypoxia-induced defects of proteostasis in C. elegans
- Impaired proteostasis in senescent vascular endothelial cells: a perspective on estrogen and oxidative stress in the aging vasculature
- Proteostasis impairment: at the intersection between Alzheimer’s disease and diabetes
- Probing tumour proteostasis and the UPR with serum markers
- Potential influence of cyclo (his-pro) on proteostasis: Impact on neurodegenerative diseases
- Proteostasis in epicardial versus subcutaneous adipose tissue in heart failure subjects with and without diabetes
- Mitochondria and proteostasis: it’sa kind of MAGIC
- Homeostatic interplay between FoxO proteins and ER proteostasis in cancer and other diseases
- cindr, the Drosophila homolog of the CD2AP Alzheimer’s disease risk gene, is required for synaptic transmission and proteostasis
- Hsp90 maintains proteostasis of the galactose utilization pathway to prevent cell lethality
- Restoring podocyte proteostasis in DN
- Targeting the proteostasis network in rhodopsin retinitis pigmentosa
- Ribosome-associated chaperones act as proteostasis sentinels
- Role of Derlin-1 protein in proteostasis regulation of ATP-sensitive potassium channels
- Transglutaminase type 2 in the regulation of proteostasis
- Hormetic heat shock and HSF-1 overexpression improve C. elegans survival and proteostasis by inducing autophagy
- Abnormal Osmotic Avoidance Behavior in C. elegans Is Associated with Increased Hypertonic Stress Resistance and Improved Proteostasis
- Overexpression of SIRT3 disrupts mitochondrial proteostasis and cell cycle progression
- Targeting endoplasmic reticulum acetylation to restore proteostasis in Alzheimer’s disease
- (off) Targeting UPR signaling: the race toward intervening ER proteostasis
- The AAA ATPase Afg1 preserves mitochondrial fidelity and cellular health by maintaining mitochondrial matrix proteostasis
- Targeting proteostasis through the protein quality control function of the Hsp90/Hsp70-based chaperone machinery for treatment of adult onset …
- Proteostasis and diseases of the motor unit
- Mild exercise differently affects proteostasis and oxidative stress on motor areas during neurodegeneration: a comparative study of three treadmill running protocols
- Expression‐level dependent perturbation of cell proteostasis and nuclear morphology by aggregation‐prone polyglutamine proteins
- Assessing proteostasis and proteasome stress in light chain amyloidosis
- Beyond proteostasis: Roles of type I chaperonins in bacterial pathogenesis
- Quality control mechanisms of protein biogenesis: proteostasis dies hard
- Gene expression modulation by the linker of nucleoskeleton and cytoskeleton complex contributes to proteostasis
- Aberrations in proteostasis orchestrate: The genotypic and phenotypic changes in aging
- RESEtting proteostasis
- Uncoupling the trade-off between somatic proteostasis and reproduction in Caenorhabditis elegans models of polyglutamine diseases
- Hexapeptide-11 is a novel modulator of the proteostasis network in human diploid fibroblasts
- RESET ing ER proteostasis: selective stress pathway hidden in the secretory route
- Proteostasis or aging: let the CHIPs fall where they may
- Genetic Interactions Between BOB1 and Multiple 26S Proteasome Subunits Suggest a Role for Proteostasis in Regulating Arabidopsis Development
- Post-transcriptional negative feedback regulation of proteostasis through the Dis3 ribonuclease and its disruption by polyQ-expanded Huntingtin
- DNAJC12: A molecular chaperone involved in proteostasis, PKU, biogenic amines metabolism and beyond?
- Royal jelly promotes DAF-16-mediated proteostasis to tolerate β-amyloid toxicity in C. elegans model of Alzheimer’s disease
- Transcriptome-wide analysis links the short-term expression of the b isoforms of TIA proteins to protective proteostasis-mediated cell quiescence response
- In search of a cure for proteostasis-addicted cancer: a AAA target revealed
- Correctors rescue CFTR mutations in nucleotide-binding domain 1 (NBD1) by modulating proteostasis
- The Wilms tumor protein Wt1 contributes to female fertility by regulating oviductal proteostasis
- HSP90 et al.: chaperome and proteostasis deregulation in human disease
- An iTRAQ proteomics screen reveals the effects of the MDM2 binding ligand Nutlin-3 on cellular proteostasis
- Gene therapy in Parkinson’s disease: targeting the endplasmic reticulum proteostasis network
- Role of second-hand smoke (SHS)-induced proteostasis/autophagy impairment in pediatric lung diseases
- Quantifying Chaperone-Mediated Transitions in the Proteostasis Network of E. coli
- Progress toward development of a proteostasis drug for myocilin-associated glaucoma
- The disruption of proteostasis in neurodegenerative disorders
- The inhibition of IGF‐1 signaling promotes proteostasis by enhancing protein aggregation and deposition
- Impairments in age-dependent ubiquitin proteostasis and structural integrity of selective neurons by uncoupling Ran GTPase from the Ran-binding domain 3 of …
- Longevity and GAPDH stability in bivalves and mammals: a convenient marker for comparative gerontology and proteostasis
- Perforin proteostasis is regulated through its C2 domain: supra-physiological cell death mediated by T431D-perforin
- The regulation of proteostasis in glial cells by nucleotide receptors is key in acute neuroinflammation
- mTOR signaling in proteostasis and its relevance to autism spectrum disorders
- Quantification of Cellular Proteostasis in Live Cells by Fluorogenic Assay Using the AgHalo Sensor
- Lysine trimethylation regulates 78-kDa glucose-regulated protein proteostasis during endoplasmic reticulum stress
- Nature versus nurture: does proteostasis imbalance underlie the genetic, environmental, and age-related risk factors for Alzheimer’s disease?
- Proteostasis goes global
- Proteostasis alterations in myeloproliferative neoplasms: Oncogenic relevance and therapeutic opportunities
- Role of the deubiquitinating enzyme ubiquitin-specific protease-14 in proteostasis in renal cells
- An HSP90 co-chaperone controls circadian proteostasis
- A42 Reactive astrocytes promote proteostasis in huntington’s disease
- Heat-shock proteins and molecular chaperones: role in regulation of cellular proteostasis and stress management
- Mechanisms regulating proteostasis are involved in sympatric speciation of the blind mole rat, Spalax galili
- Proteome imbalance is linked with proteostasis decline and aggregation in aging C. elegans
- Low erythrocyte levels of proteasome and acyl-peptide hydrolase (APEH) activities in Alzheimer’s disease: a sign of defective proteostasis?
- Autophagy and Proteostasis
- NRF2 controls proteostasis through the transcriptional regulation of autophagy
- Effect of liposome-encapsulated hemoglobin resuscitation on proteostasis in small intestinal epithelium after hemorrhagic shock
- … loss of prolyl isomerase or chaperone activity of Ran-binding protein 2 (Ranbp2) unveils distinct physiological roles of its cyclophilin domain in proteostasis
- Impaired proteostasis contributes to renal tubular dysgenesis
- Redox Status and Proteostasis in Ageing and Disease
- Too salty for worms: hypertonic stress challenges proteostasis networks. Focus on “Hypertonic stress induces rapid and widespread protein damage in C …
- Proteostasis and Energetics as Proteome Hallmarks of Aging and Influenza Challenge in Pulmonary Disease
- Heterogeneity in heat shock response dynamics caused by translation fidelity decline and proteostasis collapse
- Proteostasis therapeutics
- Meeting Report–proteostasis in Ericeira
- ML346: a novel modulator of proteostasis for protein conformational diseases
- Evaluation of Xie et al.: Sphingolipid Modulation Activates Proteostasis Programs to Govern Human Hematopoietic Stem Cell Self-Renewal
- Alteration of the proteostasis network of plant cells promotes the post-endoplasmic reticulum trafficking of recombinant mutant (L444P) human β-glucocerebrosidase
- Probing the proteostasis network
- Cellular responses to proteostasis perturbations reveal non-optimal feedback in chaperone networks
- Temporally distinct regulation of pathways contributing to cardiac proteostasis during the acute and recovery phases of sepsis
- Geroscience From Cell-body Dynamics and Proteostasis Cooperation Supported by αB-crystallin and Human will~ A Proposal of “Body-Mind Integrative Science”
- Correction: Spatial quality control bypasses cell-based limitations on proteostasis to promote prion curing
- Fibrillin-1 mgΔlpn Marfan syndrome mutation associates with preserved proteostasis and bypass of a protein disulfide isomerase-dependent quality checkpoint
- Limiting influenza virus, HIV and dengue virus infection by targeting viral proteostasis
- Plant proteostasis: methods and protocols
- Author correction: dynamic ubiquitylation of Sox2 regulates proteostasis and governs neural progenitor cell differentiation
- Semen modulated secretory activity of oviductal epithelial cells is linked to cellular proteostasis network remodeling: Proteomic insights into the early phase of …
- Editorial (Hot Topic: Proteostasis-Imbalance and Pathogenesis of Chronic Obstructive Lung Diseases)
- N-term 2017: proteostasis via the N-terminus
- Hsp60 and Hsp70 chaperones: Guardians of mitochondrial proteostasis
- Targeting the Cyclophilin domain of Ran-binding Protein 2 (Ranbp2) with novel small molecules to control the proteostasis of STAT3, hnRNPA2B1 and M-Opsin
- Heat shock transcription factor 1 is activated as a consequence of lymphocyte activation and regulates a major proteostasis network in T cells critical for cell division …
- Catalytic linkage between caspase activity and proteostasis in Archaea
- Stretching to understand how proteostasis and the unfolded protein response regulate lung injury
- The novel tumor suppressor AIRAPL regulates IGF1R proteostasis
- Proteostasis function and disfunction: the folding machines that maintain proteome health
- Modulation of proteostasis and protein trafficking: a therapeutic avenue for misfolded G protein-coupled receptors causing disease in humans
- HSF1 is activated as a consequence of lymphocyte activation and regulates a major proteostasis network in T cells critical for cell division during stress
- Erratum to “Resveratrol Attenuates Copper-Induced Senescence by Improving Cellular Proteostasis”
- Circadian rhythms and proteostasis in aging
- Proteostasis and adaptation to high temperature stress
- Loss of Proteostasis as a substrate for Atrial Fibrillation
- Proteome Aggregation Patterns Under Proteostasis Stress as Signatures for Understanding Huntington’s Disease
- The Discovery and Characterization of Small Molecule 20s Proteasome Activators: Implications in Proteostasis Disorders
- The first Autumn School on Proteostasis: from molecular mechanisms to organismal consequences
- Cell stress and proteostasis networks in biology, aging, and disease
- Alpha-1 antitrypsin deficiency: A model of alteration of protein homeostasis or proteostasis
- Amyloidogenic Proteins Drive Hepatic Proteostasis Remodeling in an Induced Pluripotent Stem Cell Model of Systemic Amyloid Disease
- P12 proteostasis as a therapeutic target in glomerular injury
- TXLNB is a Novel Regulator of Cardiac Proteostasis
- Links between Aging and Proteostasis Decline in Saccharomyces cerevisiae
- Thiol-Based Redox Signaling: Impacts on Molecular Chaperones and Cellular Proteostasis
- CHIPped balance of proteostasis and longevity
- Inhibition of ER stress-induced autophagy preserves proteostasis and protects against cardiomyocyte dysfunction in experimental and human Atrial Fibrillation
- In vivo interaction proteomics reveal a novel p38MAPK/Rack1 pathway regulating proteostasis in Drosophila muscle
- THE DECLINE OF PROTEOSTASIS IN AGING
- CHIP as a membrane-shuttling proteostasis sensor
- Proteostasis network in Down Syndrome, The
- Active role of free RNA during the early phase of proteostasis stress
- Proteostasis in retinal pigment epithelial cells: Relevance to age-related macular degeneration
- Restore the Secretion and Activity of Factor VIII Mutants By Proteostasis Regulator
- Small molecule osmolytes can modulate proteostasis
- The Role of AMPK in the Regulation of Skeletal Muscle Proteostasis During Cancer Cachexia
- Combating Parkinson’s disease-associated toxicity by modulating proteostasis
- Plastid Proteostasis: Relevance of Transcription, Translation, and Post-translational Modifications
- Different Mutations in Cilia Preassembly Gene HEATR2 Are Associated with Variable Clinical Phenotypes and Defects in Proteostasis
- The endoplasmic reticulum chaperone, GRP78, protects against the adverse effects of cigarette smoke on lung cell proteostasis
- Proteostasis Maintenance of γ-aminobutyric Acid Type A Receptors (GABAARs)
- Thiol-based Misfolding: Linking Redox Balance to Cytosolic Proteostasis
- Signaling Pathways of Proteostasis Network Unraveled by Proteomic Approaches on the Understanding of Misfolded Protein Rescue
- The Role of Fatty Acids on Endoplasmic Reticulum Proteostasis in Non-Alcoholic Fatty Liver Disease
- Role of HSPB8 in the proteostasis network: from protein synthesis to protein degradation and beyond
- Type I collagen proteostasis
- D17 STOP, DROP, AND DIE: PROTEOSTASIS AND AUTOPHAGY IN THE LUNG: Proteasome Function In The Aging Lungs
- Proteostasis collapse halts G1 progression and delimits replicative lifespan
- Non-cell Autonomous Maintenance of Proteostasis by Molecular Chaperones and Its Molecular Mechanism
- … phosphate affinity chromatography (PIP chromatography) for the isolation of proteins involved in protein quality control and proteostasis mechanisms in plants
- Aging Skeletal Muscle Proteomics Finds Changes in Spliceosome, Immune factors, Proteostasis and Mitochondria
- Fasting protects against proteostasis defects induced by hypoxia
- Epitranscriptomics: translational regulation of metabolism, drug resistance and proteostasis during cellular stress
- Linking cellular proteostasis to yeast longevity
- The impact of proteostasis imbalance on proteome solubility
- Yeast FIT2 homologs mediate the crosstalk between stress response pathways and cellular proteostasis
- Plant Proteostasis
- Boosting proteostasis
- The role of mTORC1 in muscle proteostasis
- Amyloidogenic Proteins Drive Hepatic Proteostasis Remodeling in an Induced Pluripotent Stem Cell Model of Systemic Amyloid Disease
- Neuronal Proteostasis is mediated by the switch-like expression of Heme-regulated Kinase 1, acting as both a sensor and effector
- D17 STOP, DROP, AND DIE: PROTEOSTASIS AND AUTOPHAGY IN THE LUNG: Non-Canonical Autophagy And The Anti-Fibrotic Effects Of Bibf-1120 In Ipf
- Impact of Loss of Proteostasis on Central Nervous System Disorders
- Surfaceome dynamics during neuronal development and synaptic plasticity reveal system-wide surfaceome reorganization independent of global proteostasis
- Proteostasis: Found in translation
- Restoring proteostasis to ameliorate disease
- The Yeast AIF Homolog Nde1 Integrates Signals from Metabolism and Proteostasis on the Mitochondrial Surface and Executes Cell Death
- Towards the quantification of the proteostasis capacity of a cell
- Endoplasmic reticulum proteostasis impairment in aging
- Regulation of cellular Hsp70: Proteostasis and aggregate management
- Global Quantification of Proteostasis Regulation
- Investigations into the mechanisms of neuronal proteostasis
- Molecular mechanisms regulating cellular proteostasis
- Compensation of select proteostasis networks after Hsp70 inhibition in cancer
- ER stress and lipid droplet-dependent proteostasis in response to lipid stress in yeast and a novel congenital muscular dystrophy
- Proteostasis and Myeloid Stem Cell Production
- Cellular Mechanisms of Proteostasis: Cigarette smoke-induced autophagy impairment accelerates lung aging, COPD-emphysema exacerbations and …
- A co-translational folding reporter to monitor proteostasis
- PI3K/AKT Signaling Activates HSF1 to Preserve Proteostasis and Sustain Growth
- 599Caenorhabditis elegans Aging is Associated with a Decline in Proteostasis
- N1-methyladenine safeguards against aberrant RNA-protein association during proteostasis stress
- Proteostasis and the aging pathways
- Effect of Treatment with a NRF2 Activator on In Vivo Proteostasis in Mice
- Hsp70: A Multi-Tasking Chaperone at the Crossroad of Cellular Proteostasis
- An Emergent Paradigm for Vision Research: Proteostasis, Variation and Precision Management of Human Disease
- The Decline of Adaptive Homeostasis & Adaptive Proteostasis in Ageing
- T180. Unraveling the Effect of Physiological Stress on Chaperone Mediated Autophagy-Dependent Synaptic Proteostasis
- Mitochondrial Proteostasis and Hypoxic Injury
- AJP-Cell Physiology begins a theme series on the control of the proteostasis network in health and diseases
- Sphingolipid Perturbation Activates Proteostasis Programs to Govern Human Hematopoietic Stem Cell Self-Renewal
- Endoplasmic reticulum proteostasis impairment in aging
- Mechanisms of Division Site Selection and Role of the ATP-Dependent Protease ClpXP in Mind Regulation and Proteostasis in E. coli
- Molecular probe for measuring proteostasis decline in cells
- Deregulated expression of the HSP40 family members Auxilin-1 and-2 is indicative of proteostasis imbalance and predicts patient outcome in Ph+ leukemia
- Epigenetics and proteostasis in correction of misfolding disease
- PROTEOSTASIS IN BUDDING YEAST
- Proteostasis and Aging in Saccharomyces cerevisiae-The role of a Peroxiredoxin
- Max Delbruck Prize in Biological Physics Talk: The Physics of Cellular Proteostasis
- Healthspan‐Extending Treatments Enhance Proteostasis through Reduced Cellular Proliferation
- Proteostasis and Senescence in the Aging Lung
- SAGA regulates mRNA quality control and export for proteostasis
- Targeting Proteostasis in Atrial Fibrillation
- MAINTENANCE OF PROTEOSTASIS AS A PILLAR OF SLOWED AGING: LESSONS FROM LONG-LIVED MURINE MODELS
- Endoplasmic reticulum, oxidative stress and their complex crosstalk in neurodegeneration: proteostasis, signaling pathways and molecular chaperones
- Are proteostasis defects responsible for amyotrophic lateral sclerosis?
- Evaluation of a novel phytochemical Nrf2 activator on cytoprotective gene expression and proteostasis in vivo
- Novel Genetic Modulators Regulate Healthspan by Altering Proteostasis
- Proteostasis perturbation destabilizes respiratory complex assembly-intermediates via aggregation of subunits
- Functions of The Seventeen Kilodalton Protein in Escherichia coli Proteostasis
- Modulation of Developmental Signaling by the Proteostasis Network
- Yeast Proteostasis under Acute Stress
- A Fluorogenic Proteostasis Sensor to Monitor Proteome Stress in Real‐Time
- Proteostasis and Chaperone Surveillance
- Adapting the Chemistry and/or Biology of Proteostasis to Ameliorate Protein Aggregation Diseases
- Inhibition of ER Translocation by Chaperone HSPA13 and Consequences for Proteostasis
- Ankyrin-B: proteostasis and impact on cardiomyocyte behaviours in H9c2 cells
- Respiratory chain deficiency alters cellular proteostasis and triggers Alzheimer’s disease-like tau alterations
- Caloric restriction rescues yeast cells from alpha-synuclein toxicity through autophagic control of proteostasis
- Endoplasmic reticulum proteostasis impairment in aging
- Chaperone-directed ubiquitylation maintains proteostasis at the expense of longevity
- Regulation of Functional Proteome by the Heat Shock Response and Proteostasis Network
- The disruption of proteostasis in neurodegenerative diseases
- Abstract B73: Proteostasis network modules as molecular targets for cancer therapeutics.
- Pharmacologic ATF6 Activation Confers Global Protection in Widespread Disease Models by Reprogramming Cellular Proteostasis
- Small heat shock proteins: Their role in proteostasis and neurodegeneration
- Proteostasis and SUMO in the heart.
- Age-related Decline of the Adaptive Proteostasis Gene Program in Cardiac Myocytes
- Translation Attenuation by Minocycline Increases Lifespan and Improves Proteostasis in Old Post-Stress-Responsive Organisms
- Redox Status and Proteostasis in Ageing and Disease
- Proteostasis disturbance in amyotrophic lateral sclerosis
- A confocal microscopy investigation of the release of chaperones from the endoplasmic reticulum during proteostasis stress
- Proteostasis function and disfunction: the delicate art of maintaining a healthy proteome
- Targeting proteostasis in atrial fibrillation
- Regulating proteostasis: a study of interactions between HSP70 proteins, HSP40 proteins, and the sigma 1 receptor
- Adapting Proteostasis to Ameliorate Loss‐and Gain‐of‐Function Diseases
- Proteostasis control by the unfolded protein response
- Effects of impaired proteostasis on tissue physical properties in a model of bone-like tissue formation
- Regulating proteostasis by a chemical genetics approach
- Treatment with rapamycin or rapamycin in combination with metformin contributes to mechanisms of mitochondrial proteostasis in vivo and in vitro
- Correction: Gene therapy in Parkinson’s disease: targeting the endoplasmic reticulum proteostasis network Valentina Castillo, Gabriela Mercado, Claudio Hetz
- The functional nonequivalence of α-crystallins in the lens proteostasis network
- Prion proteostasis
- Study of the endoplasmic reticulum proteostasis network during ageing
- Mechanistic Understanding, Biochemical Modulation, and Autophagic Degradation of Mammalian Proteasomes, and Their Pathological Implications in Proteostasis
- A role of SUMOylation in proteostasis, centromere integrity and the DNA damage
- ROLE OF CARBONYL MODIFICATIONS ON AGING-ASSOCIATED LOSS OF PROTEOSTASIS
- Mechanisms of cellular proteostasis: insights from single molecule approaches (226.3)
- Adapting Proteostasis Through Stress-Responsive Signaling
- The Proteostasis System in Nematodes and Baker´ s Yeast
- Regulating Secretory Proteostasis through the Unfolded Protein Response:[249_TD $ DIFF] From Function to Therapy
- Monitoring ER calcium and ER proteostasis under hypoxic conditions
- Coordinated Control of Proteostasis in Neuronal Stress Response and Neurodegenerative Diseases
- Proteostasis Modulators with Discriminating Taste
- The Proteostasis Function of the Saccharomyces Cerevisiae Metacaspase Yca1
- Chaperone network based on cellular response reveals the non-optimal response to perturbed proteostasis
- A Role for PI31-Mediated Proteasome Regulation in Proteostasis and Neuronal Health
- Distant chaperones and N-glycan signals: new mechanisms of secretory pathway proteostasis
- Neurodegenerative stress related mitochondrial proteostasis
- The transcriptome of proteostasis perturbations reveal non-optimal response in chaperone networks
- Interactome Changes Quantified to Identify the ER Proteostasis Network to Fight Amyloid Diseases
- HSP-inducing compounds as therapeutics to restore proteostasis in Atrial Fibrillation
- ATF6 Activation Remodels the Endoplasmic Reticulum Proteostasis Network to Restore Proteostasis of Pathogenic GABAA Receptors
- Monitoring Proteostasis in Populations of Living E. coli Cells at the Single-Cell Level
- Emergent Properties of Proteostasis in CFTR Folding and Misfolding
- D17 STOP, DROP, AND DIE: PROTEOSTASIS AND AUTOPHAGY IN THE LUNG: Acute Lung Injury Is Associated With Altered Proteostasis In The Lung Epithelium
- AGING-LINKED PROTEOSTASIS DECLINE: IMPLICATIONS FOR NEURODEGENERATIVE DISEASE
- Polyphenols and proteostasis: The role of heat shock response and the ubiquitin-proteasome system
- Understanding the role of tRNA modifying enzymes in proteostasis in human health and disease–FCT
- The modulation of tau proteostasis in tauopathies by NUB1/NUB1L interaction with the autophagy-lysosomal pathway
- RESETing ER proteostasis: Selective stress pathway hidden in the secretory route
- Abstract A03: Perturbation of proteostasis is lethal in SMARCB1-deficient tumors
- The Age-Dependent Collapse of Proteostasis: A Polyglutamine Model for Protein Misfolding Disorders
- Targeting proteostasis in atrial fibrillation: Molecular footprints and novel therapeutic strategies
- Organismal proteostasis: role of cell-nonautonomous regulation and
- Identifying small molecule regulators of the Proteostasis Network that enhance CFTR protein function
- ribosome-bound quality control complex: from aberrant peptide clearance to proteostasis maintenance
- Membrane Dynamics of Lipid Droplet-Mediated ER Proteostasis in the Budding Yeast, Saccharomyces cerevisiae
- PROTEOSTASIS OF THE TONOPLAST: SYNTHESIS, SORTING AND TURNOVER OF THE POTASSIUM CHANNEL ATTPK1
- Circadian control and proteostasis in NRF-2/PGC-1 alpha knock-out mice
- Contribution of Satellite Cells to Skeletal Muscle Proteostasis during Advanced Age and Aerobic Exercise
- Monitoring the Proteostasis Function of the Saccharomyces cerevisiae Metacaspase Yca1
- Targeting protein‐protein interactions in chaperone complexes to normalize proteostasis
- Abstract B40: Perturbation of proteostasis is lethal in SMARCB1-deficient tumors
- A39 Triad of neuronal vulnerability in huntington’s disease: huntingtin proteostasis, inclusion body formation and mitochondrial function
- Proteostasis Responses to Endogenous Alpha-Synuclein Aggregation in the Brain
- Nuclear targeting of Hsp110 modifies the proteostasis system by mobilizing latent Hsp70 chaperones
- Resveratrol Induces Brain Resilience Against Alzheimer Neurodegeneration Through Proteostasis Enhancement
- mberHappily (n) ever after: Aging in the context of oxidative stress, proteostasis loss and cellular senescence
- Investigating the impact of small molecule ligands and the proteostasis network on protein folding inside the cell
- Measuring proteostasis capacity using transiently transfected bait proteins by flow cytometry
- Loss of proteostasis in brain vascular endothelial cells in an in vitro model of alzheimer’s disease
- Understanding Dysregulated Collagen‐I Proteostasis Linked to Osteogenesis Imperfecta
- Drug repurposing to target proteostasis and prevent neurodegeneration: accelerating translational efforts
- Exploring the Impact of the E. coli Proteostasis Network on the Folding Fate of Proteins with Different Intrinsic Biophysical Properties
- Prion initiation in vivo Requires Limitations in the Proteostasis Network
- A systems biology approach to the correction of Cystic Fibrosis: from building a network of proteostasis regulatory pathways to combinatorial targeting
- TFEB regulates lysosomal proteostasis
- The Role of proteases and chaperones in extracellular proteostasis
- Cytoprotective alpha crystallins in the regulation of RPE cell proteostasis
- Resveratrol induces resilience against age-related neurodegeneration through improvement of proteostasis
- Restoring Proteostasis via Chaperone Networks in Ageing and Neurodegenerative Disease
- The proteostasis of the endoplasmic reticulum and the activation of the unfolded protein response pathway in vivo
- Restoring Epilepsy‐Associated Mutant GABAA Receptor Proteostasis
- Defining the Proteostasis Network Responsible for Managing the Fate of Newly Synthesized Alpha1-Antitrypsin
- Results of a high-throughput screen to identify compounds that modulate VHL proteostasis.
- Cellular Mechanisms of Proteostasis: Ulk1-mediated autophagy plays an essential role in mitochondrial remodeling and functional regeneration of skeletal …
- The unfolded protein response: from regulator of proteostasis to stimulator of malignancies
- Glycation disrupts proteostasis and promotes neurodegenerative alterations in synucleinopathies
- Research Topic: Plastid Proteostasis: Relevance of Transcription, Translation, and Post-translational Modifications
- Absence of collagen XVIII in mice causes age-related insuffiency in retinal pigment epithelium proteostasis
- Autophagy, FOXO1 and proteostasis: implications for human diseases
- Hormetic Effects of Zerumbone in Proteostasis
- Lack of collagen XVIII in mice evokes age‐dependent deficiency in retinal pigment epithelium proteostasis
- CSIG-03. CYCLIC DEPSIPEPTIDE LIGANDS TO TARGET CO-TRANSLATIONAL TRANSLOCATION AND ER PROTEOSTASIS IN GLIOBLASTOMA CELLS
- Intravitreal injection of novel small molecule proteostasis regulators activates the Unfolded Protein Response in murine retina
- proteostasis defects by inhibition of PPP1R15A could benefit many conditions characterized by the accumulation of misfolded proteins.
- In vivo activation of the endoplasmic reticulum unfolded protein response without disturbed proteostasis
- Tau proteostasis in stress-triggered neuronal dysfunction: implications for Alzheimer´ s disease
- Host vs Virus: HSV has evolved to evade host antiviral mechanisms by manipulating the host proteostasis machinery
- A Small Molecular Activator of the ER Proteostasis Regulator, ATF6, is Beneficial in the Ischemic Heart
- The pivotal role of proteasome enhancement in ageing, longevity and proteostasis across species
- PUB127 Role of microRNAs and Proteostasis System in Diesel Exhaust Particle Induced Lung Toxicity
- Direct Substrate Recognition by the ATP-Dependent Chaperone Protease CLPXP and Roles in Proteostasis
- Nrf2‐ and PGC‐1α‐deficient mice: A novel animal model for disturbed proteostasis and RPE degeneration
- Targeting oncoproteins via disruption of proteostasis: Identification of oncoprotein destabilizing agents using luciferase tagged oncoproteins
- Reprogramming the proteostasis network to prevent the accumulation of alpha-synuclein aggregates
- Molecular And Cellular Networks in Critical Illness Associated Muscle Weakness: Skeletal Muscle Proteostasis in the Intensive Care Unit
- P436 Role of myocardial proteostasis in hypoxic tolerance: effect of chemical chaperones and er stress inducers.
- Modulation of Proteostasis for the Efficient Intracellular Transport of the ΔF508 Mutant of Cystic Fibrosis Transmembrane Conductance Regulator
- The Regulation of ER Chaperones and Proinsulin Proteostasis by Perk EIF2ALPHA Kinase
- Effects of different ratios of medicine dosage for isoflurane and propofol on GABAAreceptor α1sub-unit proteostasis during hypoxia injury to hippocampal neurons of …
- Proteostasis by HSP70/STUB1 complex regulates androgen receptor variants expression and confers resistance to enzalutamide and abiraterone
- p97 is Critical for Cardiac Proteostasis and Dysregulation of p97 Activity Causes Cardiomyopathy
- Quaternary dynamics underlie the chaperone function of Hsp27 and αB-crystallin in maintaining proteostasis
- Unfolded protein response coordinates autophagy in maintaining proteostasis and clonal survival of limbal stem cells under UVA stress
- Linking the Conformational Landscape of Huntingtin to Proteostasis and Neurotoxicity in Huntington’s Disease
- Loss of Sil1, an ER Co‐Chaperone, Causes an Age‐Dependent Collapse of Skeletal Muscle Proteostasis, Affecting Pathways Critical for Muscle Physiology
- The P5 Type ATPase Atp13A2, a Parkinson associated gene, coordinates key trafficking mechanisms involved in the maintenance of cancer cell proteostasis
- Proteostasis in C. elegans is maintained during extreme osmotic stress by reduced translation with resultant increases in molecular chaperone capacity
- D17 STOP, DROP, AND DIE: PROTEOSTASIS AND AUTOPHAGY IN THE LUNG: Autophagy Is Required For Neutrophil-Mediated Inflammation
- Compromised Mutant EFEMP1 Secretion Associated with Macular Dystrophy Remedied by Proteostasis Network Alteration John D. Hulleman, Shalesh Kaushal …
- Elucidating the mechanism of action of a small molecule proteostasis regulator with potential relevance for treatment of the lysosomal storage disease …
- C60 QUALITY CONTROL IN LUNG CELLS: AUTOPHAGY AND PROTEOSTASIS: Toxicity Of Carbon Nanotubes: The Role Of Autophagy
- Hsf1 Activation Regulates The Transcriptional Activity Of The Heat Shock And Unfolded Protein Responses Altering Myeloid Proteostasis And Driving Granulopoeisis
- Cardiolipin exposure on the outer mitochondrial membrane modulates α‐synuclein proteostasis in hPSC‐derived Parkinson’s Disease neurons
- … Small Molecule Protects Against Myocardial Ischemia and Doxorubicin-Induced Cardiomyopathy Through Heat Shock Response and Proteostasis Regulation In Vivo
- … : Hsf1 Activation Regulates The Transcriptional Activity Of The Heat Shock And Unfolded Protein Responses Altering Myeloid Proteostasis And Driving Granulopoeisis
- C60 QUALITY CONTROL IN LUNG CELLS: AUTOPHAGY AND PROTEOSTASIS: Altered Proteasome Function In Pulmonary Fibrosis
- C60 QUALITY CONTROL IN LUNG CELLS: AUTOPHAGY AND PROTEOSTASIS: Transcriptional Regulation Of Autophagy By Stat1
- D17 STOP, DROP, AND DIE: PROTEOSTASIS AND AUTOPHAGY IN THE LUNG: Epigenetic Repression Of Autophagy Machinery In Idiopathic Pulmonary Fibrosis …
- D17 STOP, DROP, AND DIE: PROTEOSTASIS AND AUTOPHAGY IN THE LUNG: Autophagy Regulates Mucin Expression In Chronic Airway Inflammation
- C60 QUALITY CONTROL IN LUNG CELLS: AUTOPHAGY AND PROTEOSTASIS: Comparison Of Liver And Lung Macroautophagy Substrate Proteomes Reveals …
- Regulation of Nucleocytoplasmic Partitioning and Proteostasis of Substrates and Chemokine Signaling by Ran-binding protein 2 (Ranbp2) in Thy1+-Ganglionic …
- C60 QUALITY CONTROL IN LUNG CELLS: AUTOPHAGY AND PROTEOSTASIS: Hypercapnia Impairs Autophagy In Human Macrophages
- … communication, and the regulation of aging at the organismal level. Front. Genet. 6: 80. doi: 10.3389/fgene. 2015.00080 Proteostasis collapse, inter-tissue …
- Ryanodine receptor antagonists adapt NPC1 proteostasis to ameliorate lipid storage in Niemann-Pick type C disease fibroblasts
- … Post-Translational Modification and Subcellular Localization: Results of a High Throughput Screen to Identify Compounds that Modulate VHL Proteostasis
- C60 QUALITY CONTROL IN LUNG CELLS: AUTOPHAGY AND PROTEOSTASIS: Regulation Of Fas Expression By Tgf-[Beta] 1 Contributes To Apoptosis Resistance …
- D17 STOP, DROP, AND DIE: PROTEOSTASIS AND AUTOPHAGY IN THE LUNG: Autophagy Deficiency Blocks Il-13 Muc5ac Mediated Secretion In Airway Epithelial …
- C60 QUALITY CONTROL IN LUNG CELLS: AUTOPHAGY AND PROTEOSTASIS: Decreased Phagocytosis Is Associated With Impaired Lc3 Expression In Nicotine …
- C60 QUALITY CONTROL IN LUNG CELLS: AUTOPHAGY AND PROTEOSTASIS: The Role Of Autophagy In Murine Adipose-Derived Mesenchymal Stromal Cell …
- … : A non-BRICHOS SFTPC mutant (SP-CI73T) linked to interstitial lung disease promotes a late block in macroautophagy disrupting cellular proteostasis and …
- D17 STOP, DROP, AND DIE: PROTEOSTASIS AND AUTOPHAGY IN THE LUNG: Crosstalk Between Efferocytosis And Autophagy In Alveolar Macrophages During …
- Modulation of neuronal mitochondrial dynamics, autophagy and huntingtin proteostasis by HDAC inhibitors: Insights for Huntington’s Disease
- C60 QUALITY CONTROL IN LUNG CELLS: AUTOPHAGY AND PROTEOSTASIS: Rapamycin Protects Ova Induced Asthma In Mice Through Regulating Autophagy
- MP22-08 PROTEOSTASIS BY HSP70/STUB1 COMPLEX REGULATES ANDROGEN RECEPTOR VARIANTS EXPRESSION AND CONFERS RESISTANCE TO …
- C60 QUALITY CONTROL IN LUNG CELLS: AUTOPHAGY AND PROTEOSTASIS: Autophagy And The Unfolded Protein Response Are Necessary For Tgf [Beta] 1 …
- C60 QUALITY CONTROL IN LUNG CELLS: AUTOPHAGY AND PROTEOSTASIS: Enhanced Autophagy Of Pulmonary Endothelial Cells On Exposure To Hiv-Protein …
- 849 The Nucleolus as a Proteostasis Regulator Fatima Amer-Sarsour and Avraham Ashkenazi 851 Apoptotic Caspases: A Double-Edged Sword in Radiation-Induced …
- D17 STOP, DROP, AND DIE: PROTEOSTASIS AND AUTOPHAGY IN THE LUNG: The Surfactant Protein C I73t Missense Mutation Induces A Cellular Phenotype …
- C60 QUALITY CONTROL IN LUNG CELLS: AUTOPHAGY AND PROTEOSTASIS: Cytosolic Alpha-1 Proteinase Inhibitor Regulates Mitochondrial Superoxide …
- Cytoplasmic Aggregates Of Human Tdp-25 Protein In C. Elegans Challenge Proteostasis
- Abstract A2-57: Identification of genetic vulnerabilities within the proteostasis network of multiple myeloma
- C108 AGING: THE COMMON DENOMINATOR: Hic-5/nox4 Signaling Regulates Proteostasis And Senescence
- A Highlights from MBoC Selection: Heat shock factor 2 is required for maintaining proteostasis against febrile-range thermal stress and polyglutamine …
- The role of PQM-1 in proteostasis and transcellular chaperone signalling
- Dynamin-Related Protein 1 Regulates Proteostasis and Proprotein Convertase Subtilisin/Kexin Type 9 Secretion
- IL‐6 modulates cardiac muscle proteostasis and anti‐oxidative capacity post‐burn
- Inhibition of Histone Deacetylase-6 (HDAC6) Protects Against Atrial Remodeling Through Derailment of a-Tubulin Proteostasis in Experimental and Human Atrial …
- Activation of Histone Deacetylase-6 (HDAC6) Induces Contractile Dysfunction Through Derailment of α-Tubulin Proteostasis in Experimental and Human Atrial …
- Activation of Histone Deacetylase-6 (HDAC6) Induces Contractile Dysfunction through Derailment of α-Tubulin Proteostasis in Experimental and Human Atrial …
- Session 9: Proteostasis and stress response
- Adapting proteostasis for disease intervention
- Functional modules of the proteostasis network
- Chemical biology framework to illuminate proteostasis
- Mitochondria-associated proteostasis
- Proteostasis failure in neurodegenerative diseases: Focus on oxidative stress
- When endoplasmic reticulum proteostasis meets the DNA damage response
- Adapting the proteostasis capacity to sustain brain healthspan
- Inflammasomes and proteostasis novel molecular mechanisms associated with atrial fibrillation
- The intrinsic proteostasis network of stem cells
- Proteostasis Disturbances and Inflammation in Neurodegenerative Diseases
- Proteostasis of islet amyloid polypeptide: a molecular perspective of risk factors and protective strategies for type II diabetes
- Cellular proteostasis decline in human senescence
- Mechanisms linking mitochondrial dysfunction and proteostasis failure
- Extracellular proteostasis prevents aggregation during pathogenic attack
- Cell-nonautonomous regulation of proteostasis in aging and disease
- The protein disulfide isomerase family: from proteostasis to pathogenesis
- Proteasome inhibitors: Harnessing proteostasis to combat disease
- QRICH1 dictates the outcome of ER stress through transcriptional control of proteostasis
- PARPs and ADP-ribosylation in RNA biology: from RNA expression and processing to protein translation and proteostasis
- Interplay between mitochondrial oxidative disorders and proteostasis in Alzheimer’s disease
- Zinc at the crossroads of exercise and proteostasis
- Mitochondrial quality control and cellular proteostasis: two sides of the same coin
- Pharmacologic IRE1/XBP1s activation confers targeted ER proteostasis reprogramming
- Mitochondria in Alzheimer’s disease and their potential role in Alzheimer’s proteostasis
- Mastering organismal aging through the endoplasmic reticulum proteostasis network
- Maternal immune activation in mice disrupts proteostasis in the fetal brain
- Build-UPS and break-downs: metabolism impacts on proteostasis and aging
- Cancer and pH dynamics: Transcriptional regulation, proteostasis, and the need for new molecular tools
- Embryo integrity regulates maternal proteostasis and stress resilience
- Proteostasis of α-Synuclein and Its Role in the Pathogenesis of Parkinson’s Disease
- Thyroglobulin interactome profiling defines altered proteostasis topology associated with thyroid dyshormonogenesis
- Disruption of cellular proteostasis by H1N1 influenza A virus causes α-synuclein aggregation
- Hematopoietic stem cell regulation by the proteostasis network
- FOXO1 deficiency impairs proteostasis in aged T cells
- Integrating ER and mitochondrial proteostasis in the healthy and diseased heart
- The dual roles of clusterin in extracellular and intracellular proteostasis
- Surfaceome dynamics reveal proteostasis-independent reorganization of neuronal surface proteins during development and synaptic plasticity
- Phosphorylation switches protein disulfide isomerase activity to maintain proteostasis and attenuate ER stress
- Molecular perspectives of mitochondrial adaptations and their role in cardiac proteostasis
- BAG3 proteomic signature under proteostasis stress
- Proteostasis failure and cellular senescence in long‐term cultured postmitotic rat neurons
- Pharmacologic approaches for adapting proteostasis in the secretory pathway to ameliorate protein conformational diseases
- Noise exposures causing hearing loss generate proteotoxic stress and activate the proteostasis network
- The yeast FIT2 homologs are necessary to maintain cellular proteostasis and membrane lipid homeostasis
- Mitochondrial proteostasis requires genes encoded in a neurodevelopmental syndrome locus
- … and meta-analysis of human transcriptomics reveals neuroinflammation, deficient energy metabolism, and proteostasis failure across neurodegeneration
- Vimentin’s side gig: Regulating cellular proteostasis in mammalian systems
- Does proteostasis get lost in translation? Implications for protein aggregation across the lifespan
- Proteostasis unbalance of nucleophosmin 1 in Acute Myeloid Leukemia: An aggregomic perspective
- Hedgehog signaling modulates glial proteostasis and lifespan
- From beta amyloid to altered proteostasis in Alzheimer’s disease
- LONP1 and ClpP cooperatively regulate mitochondrial proteostasis for cancer cell survival
- The eIF2α kinase HRI in innate immunity, proteostasis, and mitochondrial stress
- Challenging proteostasis: role of the chaperone network to control aggregation-prone proteins in human disease
- Chaperones and proteostasis: Role in Parkinson’s Disease
- Plant proteostasis-shaping the proteome: a research community aiming to understand molecular mechanisms that control protein abundance
- A Mitochondrial Stress-Specific Form of HSF1 Protects against Age-Related Proteostasis Collapse
- Mitochondrial cross-compartmental signalling to maintain proteostasis and longevity
- Therapeutic role of a cysteine precursor, OTC, in ischemic stroke is mediated by improved proteostasis in mice
- Calcium depletion challenges endoplasmic reticulum proteostasis by destabilising BiP-substrate complexes
- How autophagy can restore proteostasis defects in multiple diseases?
- VPS34 K29/K48 branched ubiquitination governed by UBE3C and TRABID regulates autophagy, proteostasis and liver metabolism
- Corrupted ER‐mitochondrial calcium homeostasis promotes the collapse of proteostasis
- Proteostasis in the Male and Female Germline: A New Outlook on the Maintenance of Reproductive Health
- The selective autophagy receptor SQSTM1/p62 improves lifespan and proteostasis in an evolutionarily conserved manner
- Redefining proteostasis transcription factors in organismal stress responses, development, metabolism, and health
- Maintaining proteostasis under mechanical stress
- Mitochondrial DNA variants modulate N-formylmethionine, proteostasis and risk of late-onset human diseases
- Proteomic analysis links alterations of bioenergetics, mitochondria-ER interactions and proteostasis in hippocampal astrocytes from 3xTg-AD mice
- Proteostasis in viral infection: Unfolding the complex virus–chaperone interplay
- The interplay between redox signalling and proteostasis in neurodegeneration: In vivo effects of a mitochondria-targeted antioxidant in Huntington’s disease …
- Targeting the mitochondria-proteostasis axis to delay aging
- Acute intermittent porphyria: an overview of therapy developments and future perspectives focusing on stabilisation of HMBS and proteostasis regulators
- Defective gating and proteostasis of human clC-1 chloride channel: molecular pathophysiology of myotonia congenita
- Fluc‐EGFP reporter mice reveal differential alterations of neuronal proteostasis in aging and disease
- Proteostasis disturbances and endoplasmic reticulum stress contribute to polycystic liver disease: new therapeutic targets
- Small-molecule endoplasmic reticulum proteostasis regulator acts as a broad-spectrum inhibitor of dengue and Zika virus infections
- A genetic screen identifies new steps in oocyte maturation that enhance proteostasis in the immortal germ lineage
- Proteostasis regulators modulate proteasomal activity and gene expression to attenuate multiple phenotypes in Fabry disease
- Raloxifene is a female-specific proteostasis therapeutic in the spinal cord
- Targeting cellular senescence based on interorganelle communication, multilevel proteostasis, and metabolic control
- Insights into the molecular basis of genome stability and pristine proteostasis in naked mole-rats
- Changes in Metabolism and Proteostasis Drive Aging Phenotype in Aplysia californica Sensory Neurons
- Starting at the beginning: endoplasmic reticulum proteostasis and systemic amyloid disease
- Altered proteostasis in neurodegenerative tauopathies
- Amyotrophic Lateral Sclerosis: Proteins, Proteostasis, Prions, and Promises
- The role of proteostasis in the regulation of cardiac intercellular communication
- Nuclear ubiquitin-proteasome pathways in proteostasis maintenance
- Proteostasis in thermogenesis and obesity
- The molecular chaperone CCT/TRiC: An essential component of proteostasis and a potential modulator of protein aggregation
- Implications of long non-coding RNAs in age-altered proteostasis
- Increased supraorganization of respiratory complexes is a dynamic multistep remodelling in response to proteostasis stress
- Nicotinamide riboside enhances mitochondrial proteostasis and adult neurogenesis through activation of mitochondrial unfolded protein response signaling …
- The Zscan4-Tet2 transcription nexus regulates metabolic rewiring and enhances proteostasis to promote reprogramming
- Membrane dynamics and protein targets of lipid droplet microautophagy during ER stress-induced proteostasis in the budding yeast, Saccharomyces cerevisiae
- Differential effects of rapamycin and metformin in combination with rapamycin on mechanisms of proteostasis in cultured skeletal myotubes
- … : Shared and divergent properties of wild type and mutant UBQLN2 in phase separation, subcellular localization, altered proteostasis pathways, and selective …
- USP11 controls R-loops by regulating senataxin proteostasis
- Systemic regulation of mitochondria by germline proteostasis prevents protein aggregation in the soma of C. elegans
- Basic limonoid modulates chaperone-mediated proteostasis and dissolve Tau fibrils
- Multiple myeloma cells are exceptionally sensitive to heat shock, which overwhelms their proteostasis network and induces apoptosis
- Pharmacologic targeting of plasma cell endoplasmic reticulum proteostasis to reduce amyloidogenic light chain secretion
- Protein synthesis in the developing neocortex at near-atomic resolution reveals Ebp1-mediated neuronal proteostasis at the 60S tunnel exit
- Proteostasis regulators as potential rescuers of PMM2 activity
- Stimulation of cytoprotective autophagy and components of mitochondrial biogenesis/proteostasis in response to ionizing radiation as a credible pro-survival strategy
- Distinct modes of balancing glomerular cell proteostasis in mucolipidosis type II and III prevent proteinuria
- PolyQ-expanded proteins impair cellular proteostasis of ataxin-3 through sequestering the co-chaperone HSJ1 into aggregates
- Resetting proteostasis with ISRIB promotes epithelial differentiation to attenuate pulmonary fibrosis
- Biological evaluation and in silico study of benzoic acid derivatives from Bjerkandera adusta targeting proteostasis network modules
- Designing novel therapies to mend broken hearts: ATF6 and cardiac proteostasis
- Dietary protein, exercise, ageing and physical inactivity: Interactive influences on skeletal muscle proteostasis
- Acute Neural and Proteostasis Messenger Ribonucleic Acid Levels Predict Chronic Locomotor Recovery after Contusive Spinal Cord Injury
- The NADH dehydrogenase Nde1 executes cell death after integrating signals from metabolism and proteostasis on the mitochondrial surface
- Nrf1 promotes heart regeneration and repair by regulating proteostasis and redox balance
- Intramitochondrial proteostasis is directly coupled to α-synuclein and amyloid β1-42 pathologies
- The proteostasis guardian HSF1 directs the transcription of its paralog and interactor HSF2 during proteasome dysfunction
- Multiomics-identified intervention to restore ethanol-induced dysregulated proteostasis and secondary sarcopenia in alcoholic liver disease
- Proteostasis is adaptive: Balancing chaperone holdases against foldases
- Elucidation of proteostasis defects caused by osteogenesis imperfecta mutations in the collagen-α2 (I) C-propeptide domain
- A novel stable isotope approach demonstrates surprising degree of age-related decline in skeletal muscle collagen proteostasis
- Insulin-induced de novo lipid synthesis occurs mainly via mTOR-dependent regulation of proteostasis of SREBP-1c
- Hsf1 promotes hematopoietic stem cell fitness and proteostasis in response to ex vivo culture stress and aging
- The aging proteostasis decline: From nematode to human
- Attenuation of ischemic stroke-caused brain injury by a monoamine oxidase inhibitor involves improved proteostasis and reduced neuroinflammation
- Genome-wide signatures of plastid-nuclear coevolution point to repeated perturbations of plastid proteostasis systems across angiosperms
- Secretory proteostasis of the retinal pigmented epithelium: Impairment links to age-related macular degeneration
- Knock-in of mutated hTAU causes insulin resistance, inflammation and proteostasis disturbance in a mouse model of frontotemporal dementia
- Mitochondria-affecting small molecules ameliorate proteostasis defects associated with neurodegenerative diseases
- A perspective on the potential involvement of impaired proteostasis in neuropsychiatric disorders
- The Role of Proteostasis Derailment in Cardiac Diseases
- Extracellular Proteostasis: Laying Siege to Pathogens
- Revealing functional insights into ER proteostasis through proteomics and interactomics
- Does inter-organellar proteostasis impact yeast quality and performance during beer fermentation?
- Author Correction: Surfaceome dynamics reveal proteostasis-independent reorganization of neuronal surface proteins during development and synaptic plasticity
- Phenotypic Discovery of Neuroprotective Agents by Regulation of Tau Proteostasis via Stress‐Responsive Activation of PERK Signaling
- Regular Exercise Participation Contributes to Better Proteostasis, Inflammatory Profile, and Vasoactive Profile in Patients With Hypertension
- Transcriptomic and proteostasis networks of CFTR and the development of small molecule modulators for the treatment of cystic fibrosis lung disease
- The Cryo-EM Effect: Structural Biology of Neurodegenerative Disease Proteostasis Factors
- Lanosterol modulates proteostasis via dissolving cytosolic sequestosomes/aggresome-like induced structures
- Role of IRE1α in podocyte proteostasis and mitochondrial health
- Double hit viral parasitism, polymicrobial CNS residency and perturbed proteostasis in Alzheimer’s disease: a data driven, in silico analysis of gene expression data
- Loss of Fis1 impairs proteostasis during skeletal muscle aging in Drosophila
- Exercise alters the mitochondrial proteostasis and induces the mitonuclear imbalance and UPR mt in the hypothalamus of mice
- Endogenous siRNAs promote proteostasis and longevity in germline-less Caenorhabditis elegans
- ATF6 as a Nodal Regulator of Proteostasis in the Heart
- Beyond Proteostasis: Lipid Metabolism as a New Player in ER Homeostasis
- Expression of mutant ubiquitin and proteostasis impairment in Kii Amyotrophic Lateral Sclerosis/Parkinsonism-Dementia Complex brains
- Proteostasis network alteration in lysosomal storage disorders: Insights from the mouse model of Krabbe disease
- Therapeutic targeting of proteostasis in Amyotrophic Lateral Sclerosis—a systematic review and meta-analysis of preclinical research
- Chaperone-mediated autophagy: a gatekeeper of neuronal proteostasis
- Therapeutic Approaches Targeting Proteostasis in Kidney Disease and Fibrosis
- Inflammation, Extracellular Matrix Remodeling, and Proteostasis in Tumor Microenvironment
- The sigma-1 receptor at the crossroad of proteostasis, neurodegeneration, and autophagy
- The transfer of specific mitochondrial lipids and proteins to lipid droplets contributes to proteostasis upon stress and aging in the eukaryotic model system …
- Protein trapping leads to altered synaptic proteostasis in synucleinopathies
- Proteostasis in dendritic cells is controlled by the PERK signaling axis independently of ATF4
- MIR-NATs repress MAPT translation and aid proteostasis in neurodegeneration
- The functions and regulation of heat shock proteins; key orchestrators of proteostasis and the heat shock response
- Proteostasis Regulators Restore Function of Epilepsy-Associated GABAA Receptors
- Determining the effects of nanoparticulate air pollution on proteostasis in Caenorhabditis elegans
- Ribosome ADP-ribosylation inhibits translation and maintains proteostasis in cancers
- Colonization of the Caenorhabditis elegans gut with human enteric bacterial pathogens leads to proteostasis disruption that is rescued by butyrate
- The chaperonin CCT8 controls proteostasis essential for T cell maturation, selection, and function
- CUL4-DDB1-CRBN E3 ubiquitin ligase regulates proteostasis of ClC-2 chloride channels: implication for aldosteronism and leukodystrophy
- Protein S-nitrosylation regulates proteostasis and viability of hematopoietic stem cell during regeneration
- Homeostatic Roles of the Proteostasis Network in Dendrites
- Pinpointing oxidative stress behind the white striping myopathy: Depletion of antioxidant defenses, accretion of oxidized proteins and impaired proteostasis
- Cleaning the molecular machinery of cells via proteostasis, proteolysis and endocytosis selectively, effectively, and precisely: intracellular self-defense and cellular …
- Divergent modulation of proteostasis in prostate cancer
- Effects of Cell Proteostasis Network on the Survival of SARS-CoV-2
- Proteostasis and proteotoxicity in the network medicine era
- The Proteome Folding Problem and Cellular Proteostasis
- Stochastic and Age‐Dependent Proteostasis Decline Underlies Heterogeneity in Heat‐Shock Response Dynamics
- Alpha 1-antitrypsin deficiency: a disorder of proteostasis-mediated protein folding and trafficking pathways
- Proteome-scale mapping of perturbed proteostasis in living cells
- Protective effects of cannabidiol on the membrane proteins of skin keratinocytes exposed to hydrogen peroxide via participation in the proteostasis network
- CSNAP, the smallest CSN subunit, modulates proteostasis through cullin-RING ubiquitin ligases
- Proteostasis Regulation in the Endoplasmic Reticulum: An Emerging Theme in the Molecular Pathology and Therapeutic Management of Familial …
- Acceleration of ageing via disturbing mTOR‐regulated proteostasis by a new ageing‐associated gene PC4
- Proteostasis dysfunction in aged mammalian cells. The stressful role of inflammation
- Inhibition of the oligosaccharyl transferase in Caenorhabditis elegans that compromises ER proteostasis suppresses p38-dependent protection against …
- Expression of Amyloidogenic Transthyretin Drives Hepatic Proteostasis Remodeling in an Induced Pluripotent Stem Cell Model of Systemic Amyloid Disease
- The Traditional Formula Kai-Xin-San Alleviates Polyglutamine-Mediated Neurotoxicity by Modulating Proteostasis Network in Caenorhabditis elegans
- Mapping sites of carboxymethyllysine modification on proteins reveals its consequences for proteostasis and cell proliferation
- Cellular proteostasis decline in human senescence
- Mitochondrial proteostasis requires genes encoded in a neurodevelopmental syndrome locus that are necessary for synapse function
- SUMOylation contributes to proteostasis of the chloroplast protein import receptor TOC159 during early development
- Understanding and exploiting interactions between cellular proteostasis pathways and infectious prion proteins for therapeutic benefit
- The impact of proteostasis dysfunction secondary to environmental and genetic causes on neurodegenerative diseases progression and potential therapeutic …
- Harnessing the Proteostasis Network in Alcohol-associated Liver Disease
- Functional genomics screen identifies proteostasis targets that modulate prion protein (PrP) stability
- The interplay between proteostasis systems and Parkinson’s disease
- Aggresomes predict poor outcomes and implicate proteostasis in the pathogenesis of pediatric choroid plexus tumors
- Deciphering the Proteotoxic Stress Responses Triggered by the Perturbed Thylakoid Proteostasis in Arabidopsis
- Lysosomes to the rescue: Anterograde axonal lysosome transport and neuronal proteostasis
- The switch-like expression of heme-regulated kinase 1 mediates neuronal proteostasis following proteasome inhibition
- Chrysanthemum zawadskil Herbich attenuates dexamethasone-induced muscle atrophy through the regulation of proteostasis and mitochondrial function
- In case of stress, hold tight: phosphorylation switches PDI from an oxidoreductase to a holdase, tuning ER proteostasis
- Regulation of the proteostasis network during enterovirus infection: A feedforward mechanism for EV-A71 and EV-D68
- The SINEB1 element in the long non-coding RNA Malat1 is necessary for TDP-43 proteostasis
- Peroxiredoxin 6 mediates protective function of astrocytes in Aβ proteostasis
- Altered transcriptome-proteome coupling indicates aberrant proteostasis in Parkinson’s disease
- Proteostasis-associated aging: lessons from a Drosophila model
- Addendum: a lysosomal switch triggers proteostasis renewal in the immortal C. elegans germ lineage
- Translational control of gene expression by eIF2 modulates proteostasis and extends lifespan
- Activation of the unfolded protein response and proteostasis disturbance in parkinsonism-dementia of Guam
- The linear ubiquitin E3 ligase-Relish pathway is involved in the regulation of proteostasis in Drosophila muscle during aging
- ATG9A regulates proteostasis through reticulophagy receptors FAM134B and SEC62 and folding chaperones CALR and HSPB1
- … Potential of Yeast Cells Depends on Overall Action of Interconnected Changes in Central Carbon Metabolism, Cellular Biosynthetic Capacity, and Proteostasis
- The Importance of Autophagy and Proteostasis in Metabolic Cardiomyopathy
- Estimating the number of protein molecules in a plant cell: a quantitative perspective on proteostasis and amino acid homeostasis during progressive drought stress
- … supplementation ameliorates hypobaric hypoxia‐induced skeletal muscle loss via attenuating endoplasmic reticulum stress response and maintaining proteostasis
- Lysosomal nucleotide metabolism regulates ER proteostasis through mTOR signaling
- Mucosal humoral immunity in cystic fibrosis-a tangled web of failed proteostasis, infection and adaptive immunity
- Proteostasis Dysfunction in Aged Mammalian Cells. The Stressful Role of Inflammation
- … selenium on modulation of expression of several non-selenoprotein genes related to key ovarian functions, female fertility, and proteostasis: a transcriptome-based …
- Functional connections between cell cycle and proteostasis in the regulation of Candida albicans morphogenesis
- Distinct metabolic states of a cell guide alternate fates of mutational buffering through altered proteostasis
- DNA Methyltransferase 1 (DNMT1) Acts on neurodegeneration by modulating proteostasis-relevant intracellular processes
- Tetraspanin1 promotes NGF signaling by controlling TrkA receptor proteostasis
- Regulation of autophagy by VPS34 branched ubiquitination controls proteostasis and liver metabolism
- Resetting proteostasis with ISRIB prevents pulmonary fibrosis
- The architecture of protein synthesis in the developing neocortex at near-atomic resolution reveals Ebp1-mediated neuronal proteostasis at the 60S tunnel …
- ER proteostasis regulators reduce amyloidogenic light chain secretion through an on-target, ATF6-independent mechanism
- Kinetic Monitoring Of Neuronal Stress Response To Proteostasis Dysfunction
- Protein intake and loss of Proteostasis in the eldery
- Temporal requirements of SKN-1/NRF as a regulator of lifespan and proteostasis in Caenorhabditis elegans
- … of endoplasmic reticulum (ER) Ca2+ stores by deletion of inositol‐1,4,5‐trisphosphate receptor type 1 promotes ER retrotranslocation, proteostasis, and protein outer …
- ADEP1 activated ClpP1P2 macromolecule of Leptospira, an ideal Achilles’ heel to deregulate proteostasis and hamper the cell survival
- High-content analysis of proteostasis capacity in cellular models of amyotrophic lateral sclerosis (ALS)
- Disruption of Endoplasmic Reticulum Proteostasis in Age-Related Nervous System Disorders
- Analysis of proteostasis during aging with western blot of detergent-soluble and insoluble protein fractions
- The diverse functions of small heat shock proteins in the proteostasis network
- Proteostasis Dysregulation in Pancreatic Cancer
- Dengue and Zika virus infection are impaired by small molecule ER proteostasis regulator 147 in an ATF6-independent manner
- A role for mitochondrial DNA in cellular proteostasis
- Allosteric HSP70 inhibitors perturb mitochondrial proteostasis and overcome proteasome inhibitor resistance in multiple myeloma
- How Isomerization and Epimerization in Long‐Lived Proteins Affect Lysosomal Degradation and Proteostasis
- METTL18-mediated histidine methylation on RPL3 modulates translation elongation for proteostasis maintenance
- DOPAL initiates αSynuclein-mediated impaired proteostasis in neuronal projections leading to enhanced vulnerability in Parkinson’s disease.
- MicroRNA Regulation and Cellular Proteostasis in Parkinson’s Disease
- Therapeutic potential of insulin-like growth factor 2 in Huntington’s disease: controlling proteostasis to alleviate the load of misfolded protein
- Regulation of ClC-2 Chloride Channel Proteostasis by Molecular Chaperones: Correction of Leukodystrophy-Associated Defect
- Distinct proteostasis states drive pharmacologic chaperone susceptibility for Cystic Fibrosis Transmembrane Conductance Regulator misfolding mutants
- Lipid droplets modulate proteostasis, SQST-1/SQSTM1 dynamics, and lifespan in C. elegans
- Metabolically Activated Proteostasis Regulators Protect Against Glutamate Toxicity by Activating NRF2
- The JAK2-STAT3 pathway controls a beneficial proteostasis response of reactive astrocytes in Huntington disease
- Impaired mRNA splicing and proteostasis in preadipocytes in obesity-related metabolic disease
- Mathematical model of a short translatable G-quadruplex and an assessment of its relevance to misfolding-induced proteostasis
- Nicotinamide riboside alleviates Parkinson’s disease symptoms but downregulates dopamine metabolism upon lactacystin-induced proteostasis failure
- Beyond Proteostasis: Lipid Metabolism as a New Player in ER Homeostasis. Metabolites 2021, 11, 52
- Characterization of Proteostasis Mechanisms in Chlamydia Trachomatis
- Proteostasis and Viral Evolution
- A virtuous cycle operated by ERp44 and ERGIC-53 guarantees proteostasis in the early secretory compartment
- Proteostasis and Disease: From Basic Mechanisms to Clinics
- Yeast FIT2 homolog is necessary to maintain cellular proteostasis by regulating lipid homeostasis
- Proteostasis and Neurodegeneration: Perspectives in the Pathogenesis of Molecular and Cellular Mechanisms
- XBP1s-Mediated Endoplasmic Reticulum Proteostasis Network Enhancement Can Selectively Improve Folding and Secretion of an Osteogenesis Imperfecta-Causing …
- Novel proteostasis reporter mouse reveals different effects of cytoplasmic and nuclear aggregates on protein quality control in neurons
- The Host Cell’s Endoplasmic Reticulum Proteostasis Network Profoundly Shapes the Protein Sequence Space Accessible to HIV Envelope
- Compartment-specific proteostasis
- Characterization of proteostasis loss in neurodegeneration using a proteomics approach
- Linking proteostasis, aging, and brain ischemia
- Ribosome protein mutant cells rely on the GR64 cluster of gustatory receptors for survival and proteostasis in Drosophila
- Nuclear Ubiquitin-Proteasome Pathways in Proteostasis Maintenance. Biomolecules 2021, 11, 54
- Autophagy and proteostasis adjustment role in normal brain function and neurodegenerative disorders
- Untargeted 1H NMR Metabolomics and Pathway Analysis Reveals Dysregulated Proteostasis in Cyclophilin D (CypD)-deficient Mice Tissues
- Phytochemical Nrf2 activator attenuates skeletal muscle mitochondrial dysfunction and impaired proteostasis in a preclinical model of musculoskeletal aging
- A new mouse model to study neuronal proteostasis
- Small Molecule ER Proteostasis Regulators Reduce Amyloidogenic Immunoglobulin Light Chain Secretion Through an On-Target, ATF6-Independent Mechanism
- New intervention strategies in aging and cancer based on gene edition and proteostasis modulation
- Proteostasis of Glial Intermediate Filaments: Disease Models, Tools, and Mechanisms
- Divergent Modulation of Proteostasis in Prostate Cancer.
- Selected Conference Abstracts from “The Regulation of Proteostasis in Cancer”
- Modifying the proteostasis status: the role of cross-organelle communication
- Regulation of proteostasis and proteasome function by cigarette smoke
- Discovery of a molecular glue that enhances UPRmt to restore proteostasis via TRKA-GRB2-EVI1-CRLS1 axis
- A genetic screen identifies processes that couple oocyte maturation to proteostasis in the immortal C. elegans germ lineage
- Muscle physiology and proteostasis–Effects of changes in muscle size and exercise
- Molecular Chaperones in Neurodegeneration: Mechanisms of Regulation in Cellular Proteostasis
- Universal protein misfolding intermediates can bypass the proteostasis network and remain soluble and non-functional
- A role of SUMOylation in proteostasis, centromere integrity and the DNA damage response
- Surfaceome dynamics reveal proteostasis-independent reorganization of neuronal surface proteins during development and synaptic plasticity
- Adapting Proteostasis and Autophagy for Controlling the Pathogenesis of Cystic Fibrosis Lung
- The interplay between arginine dimethylation and ubiquitylation coordinates TDP1 proteostasis for the repair of topoisomerase I covalent complexes
- Prolonged disturbance of proteostasis induces cellular senescence via temporal mitochondrial dysfunction and enhanced mitochondrial biogenesis in human …
- Mitochondrial DNA variants modulate proteostasis through N-formylmethionine
- Microfluidics: Stochastic and Age‐Dependent Proteostasis Decline Underlies Heterogeneity in Heat‐Shock Response Dynamics (Small 30/2021)
- Cleaning up translation failures: how Ribosome-associated Quality Control maintains cellular proteostasis
- Divergent Modulation of Proteostasis in Prostate Cancer
- … E. Coli Proteome it is Common for Proteins to Become Kinetically Trapped in Soluble, Near-Native, Non-Functional Conformations that Bypass the Proteostasis …
- Erratum to “mTOR/AMPK signaling in the brain: Cell metabolism, proteostasis and survival”,[Curr Opin Toxicol, Volume 8, April 2018, Pages 102–110](Current Opinion …
- Microglia implicated in tau proteostasis disturbances in the striatum of neurodegenerative disease patients from genotype to phenotype
- Acute neural and proteostasis mRNA levels predict chronic locomotor recovery after contusive spinal cord injury.
- Cellular proteostasis decline in human senescence
- Mechanisms of statin effects on muscle and neuronal proteostasis
- Quantitative and Multiplexed Chemical-Genetic Phenotyping Reveals the Architecture of the Proteostasis Network in Breast Cancer
- The Role of Eicosanoids in Regulating the Ubiquitin Proteasome System and Proteostasis
- GENETICALLY-DETERMINED MYB INSUFFICIENCY DIRECTLY IMPACTS ON PROTEOSTASIS IN HEMATOPOIETIC STEM CELLS PREDISPOSING TO AGE …
- Abstract A54: Targeting new links in the proteostasis network as novel therapies in high-grade serous ovarian cancer
- Increased supra-organization is a dynamic multistep remodelling of respiratory complexes against proteostasis stress
- Mapping networks of alpha-Synuclein proteostasis in cellular models of Parkinson’s disease pathology
- Erratum: Differential Effects of Rapamycin and Metformin in Combination with Rapamycin on Mechanisms of Proteostasis in Cultured Skeletal Myotubes (Journals of …
- Endogenous siRNAs promote proteostasis and longevity in germline
- Mitochondrial metabolism regulates cellular proteostasis
- Visual dysfunction in a zebrafish FASD model is associated with retinal proteostasis impairment
- Mutation‐Dependent Capacity of the ER Proteostasis Network to Quality Control Disease‐Causing Collagen Misfolding
- TID1 Maintains Mitochondrial Proteostasis and Reduces Aging Effects in Stem Cells to Enhance Their Potential Against Doxorubicin Induced Cardiac Damage
- Proteostasis Modulation Prevents Photoreceptor Pathology in Retinal Organoids
- Prolonged disturbance of proteostasis induces cellular senescence via temporal mitochondrial
- Squalene Monooxygenase at the Nexus between Cholesterol Homeostasis and Proteostasis
- Modeling of Disease-Related SFTPC Mutations Links a Challenged Lung Epithelial Proteostasis Network and Pulmonary Fibrosis
- Small Molecule Proteostasis Regulator Corrects Cone Photoreceptor Pathology in Retinal Organoids
- Neonatal Maternal Separation Modifies Proteostasis Marker Expression in the Adult Hippocampus
- Drug repurposing identifies inhibitors of the proteostasis network to augment radioiodine uptake in combinatorial approaches targeting thyroid cancer
- Folding Mitochondrial-Mediated Cytosolic Proteostasis Into the Mitochondrial Unfolded Protein Response
- Proteostasis failure and mitochondrial dysfunction leads to aneuploidy-induced senescence
- … (ER) Ca2+ efflux channel inositol-1, 4, 5-trisphosphate receptor type 1 or ryanodine receptor 2 promotes ER retrotranslocation/proteostasis in cyclic nucleotide-gated …
- Does TDP-43 Impact Neuronal Proteostasis?
- Targeting of misfolded, pathogenic TDP‐43 with rationally designed antibodies: Nonhuman/Target identification and validation studies: Proteostasis
- R&D Area for the Research and Development Objective “Understanding and medical application of proteostasis”(AMED-CREST, PRIME) Evaluation Panel Members
