GASTROPROTECTION
December 21, 2023
CERAMIDES
January 24, 2024
Ceramides in insulin resistance and lipotoxicity
Obesity predisposes individuals to the development of insulin resistance in skeletal muscle and the liver, and researchers have recently proposed two mechanisms by which excess adiposity antagonizes insulin action in peripheral tissues. First, when adipocytes exceed their storage capacity, fat begins to accumulate in tissues not suited for lipid storage, leading to the formation of specific metabolites that inhibit insulin signal transduction. Second, obesity triggers a chronic inflammatory state, and cytokines released from either adipocytes or from macrophages infiltrating adipose tissue antagonize insulin action. The sphingolipid ceramide is a putative intermediate linking both excess nutrients (i.e. saturated fatty acids) and inflammatory cytokines (e.g. tumor necrosis factor-alpha, TNFalpha) to the induction of insulin resistance. Moreover, ceramide has been shown to be toxic in a variety of different cell types (e.g. pancreatic beta-cells, cardiomyocytes, etc.), and review of the literature reveals putative roles for the sphingolipid in the damage of cells and tissues which accompany diabetes, hypertension, cardiac failure, atherosclerosis, etc. In this review, I will evaluate the contribution of ceramides in the development of insulin resistance and the complications associated with metabolic diseases.
- Lipotoxicity
- What is Lipotoxicity?
- Lipotoxicity: when tissues overeat
- Lipotoxicity in the heart
- Lipotoxicity in the liver
- Oxidative stress and Lipotoxicity
- Insulin resistance, obesity and Lipotoxicity
- Diabetes and apoptosis: Lipotoxicity
- Fatty liver and Lipotoxicity
- Lipotoxicity in the heart
- Molecular mechanisms of Lipotoxicity and glucotoxicity in nonalcoholic fatty liver disease
- Obesity and Lipotoxicity
- New aspects of Lipotoxicity in nonalcoholic steatohepatitis
- Mechanisms of Lipotoxicity in the cardiovascular system
- Lipotoxicity in the pathogenesis of obesity-dependent NIDDM: genetic and clinical implications
- Lipotoxicity, overnutrition and energy metabolism in aging
- Renal lipid metabolism and Lipotoxicity
- Lipotoxicity and glucotoxicity in type 2 diabetes: effects on development and progression
- Mitochondrial dysfunction and Lipotoxicity
- Lipid homeostasis, Lipotoxicity and the metabolic syndrome
- Role of Lipotoxicity in endothelial dysfunction
- The role of ER stress in lipid metabolism and Lipotoxicity
- Lipotoxicity in NASH
- Fatty acids, Lipotoxicity and insulin secretion
- Underlying mechanisms of renal Lipotoxicity in obesity
- Lipid accumulation in non-adipose tissue and Lipotoxicity
- Molecular mechanisms of Lipotoxicity in nonalcoholic fatty liver disease
- Mechanisms of Lipotoxicity in NAFLD and clinical implications
- Cardiac Lipotoxicity: molecular pathways and therapeutic implications
- Saturated with fat: new perspectives on Lipotoxicity
- Role of obesity and Lipotoxicity in the development of nonalcoholic steatohepatitis: pathophysiology and clinical implications
- The role of adipose tissue and Lipotoxicity in the pathogenesis of type 2 diabetes
- Role of glucotoxicity and Lipotoxicity in the pathophysiology of Type 2 diabetes mellitus and emerging treatment strategies
- Ceramides in insulin resistance and Lipotoxicity
- Adipose tissue expandability, Lipotoxicity and the metabolic syndrome—an allostatic perspective
- Gluttony, sloth and the metabolic syndrome: a roadmap to Lipotoxicity
- Insulin resistance, Lipotoxicity, type 2 diabetes and atherosclerosis: the missing links. The Claude Bernard Lecture 2009
- Lipotoxicity in type 2 diabetic cardiomyopathy
- Oxidative capacity, Lipotoxicity, and mitochondrial damage in type 2 diabetes
- Triglyceride accumulation protects against fatty acid-induced Lipotoxicity
- Lipotoxicity: effects of dietary saturated and transfatty acids
- Dysfunctional fat cells, Lipotoxicity and type 2 diabetes
- Lipid signaling and Lipotoxicity in metaflammation: indications for metabolic disease pathogenesis and treatment
- Adipose tissue function and expandability as determinants of Lipotoxicity and the metabolic syndrome
- Lipotoxicity and the gut-liver axis in NASH pathogenesis
- Lipid metabolism and signaling in cardiac Lipotoxicity
- Lipotoxicity of beta-cells in obesity and in other causes of fatty acid spillover.
- Lipotoxicity in nonalcoholic fatty liver disease: not all lipids are created equal
- Manifestations and mechanisms of myocardial Lipotoxicity in obesity
- Acyl-CoA synthesis, lipid metabolism and Lipotoxicity
- β-cell glucose toxicity, Lipotoxicity, and chronic oxidative stress in type 2 diabetes
- Fatty acids-induced Lipotoxicity and inflammation
- Probing the global cellular responses to Lipotoxicity caused by saturated fatty acids
- Hepatic Lipotoxicity and the pathogenesis of nonalcoholic steatohepatitis: the central role of nontriglyceride fatty acid metabolites
- Fatty acid-stimulated insulin secretion vs. Lipotoxicity
- Role of insulin resistance and Lipotoxicity in non-alcoholic steatohepatitis
- Evidence for right ventricular Lipotoxicity in heritable pulmonary arterial hypertension
- Peroxisomes, lipid metabolism and Lipotoxicity
- Obesity as a clinical and public health problem: is there a need for a new definition based on Lipotoxicity effects?
- Dietary fat and heart failure: moving from Lipotoxicity to lipoprotection
- Lipotoxicity in obesity and diabetes-related cardiac dysfunction
- Lipotoxicity in macrophages: evidence from diseases associated with the metabolic syndrome
- Lipotoxicity as a trigger factor of renal disease
- Lipotoxicity: many roads to cell dysfunction and cell death: introduction to a thematic review series
- Lipotoxicity in kidney, heart, and skeletal muscle dysfunction
- Lipotoxicity in the pancreatic beta cell: not just survival and function, but proliferation as well?
- High-fat diet, muscular Lipotoxicity and insulin resistance
- Lipotoxicity in obese pregnancy and its potential role in adverse pregnancy outcome and obesity in the offspring
- Serum leptin in NASH correlates with hepatic steatosis but not fibrosis: a manifestation of Lipotoxicity?
- The impact of obesity on oocytes: evidence for Lipotoxicity mechanisms
- Maternal high-fat diet triggers Lipotoxicity in the fetal livers of nonhuman primates
- Lipid oversupply, selective insulin resistance, and Lipotoxicity: molecular mechanisms
- Insulin resistance, Lipotoxicity and endothelial dysfunction
- Pancreatic steatosis in humans: cause or marker of Lipotoxicity?
- Cell-to-cell heterogeneity in lipid droplets suggests a mechanism to reduce Lipotoxicity
- Lipotoxicity causes multisystem organ failure and exacerbates acute pancreatitis in obesity
- Free fatty acids promote hepatic Lipotoxicity by stimulating TNF‐α expression via a lysosomal pathway
- Impact of Lipotoxicity on tissue “cross talk” and metabolic regulation
- Lipidomic biomarkers and mechanisms of Lipotoxicity in non-alcoholic fatty liver disease
- The VLDL receptor promotes Lipotoxicity and increases mortality in mice following an acute myocardial infarction
- Hypothalamic Lipotoxicity and the metabolic syndrome
- Lipotoxicity in HepG2 cells triggered by free fatty acids
- Maternal obesity, Lipotoxicity and cardiovascular diseases in offspring
- Foxp3 drives oxidative phosphorylation and protection from Lipotoxicity
- Sphingolipids and glycerophospholipids–the “ying and yang” of Lipotoxicity in metabolic diseases
- Lipotoxicity in human pancreatic islets and the protective effect of metformin
- Lipotoxicity, an imbalance between lipogenesis de novo and fatty acid oxidation
- Examination of ‘Lipotoxicity‘ in skeletal muscle of high‐fat fed and ob/ob mice
- Fatty acid metabolic defects and right ventricular Lipotoxicity in human pulmonary arterial hypertension
- The role of dietary protein on Lipotoxicity
- Atherogenicity of postprandial hyperglycemia and Lipotoxicity
- High-fat diet causes Lipotoxicity responses in cumulus–oocyte complexes and decreased fertilization rates
- Nontriglyceride hepatic Lipotoxicity: the new paradigm for the pathogenesis of NASH
- A critical role for PPARα-mediated Lipotoxicity in the pathogenesis of diabetic cardiomyopathy: modulation by dietary fat content
- Role of metabolically generated reactive oxygen species for Lipotoxicity in pancreatic β‐cells
- DGAT1 expression increases heart triglyceride content but ameliorates Lipotoxicity
- Pathogenesis of NASH: how metabolic complications of overnutrition favour Lipotoxicity and pro-inflammatory fatty liver disease
- Mechanisms of palmitate-induced Lipotoxicity in human osteoblasts
- Lipotoxicity contributes to endothelial dysfunction: a focus on the contribution from ceramide
- The lysosomal‐mitochondrial axis in free fatty acid–induced hepatic Lipotoxicity
- Lipotoxicity in steatohepatitis occurs despite an increase in tricarboxylic acid cycle activity
- High-fat diet–induced lysosomal dysfunction and impaired autophagic flux contribute to Lipotoxicity in the kidney
- Fatty acid-induced Lipotoxicity in pancreatic beta-cells during development of type 2 diabetes
- Peroxisome-generated hydrogen peroxide as important mediator of Lipotoxicity in insulin-producing cells
- Postprandial fatty acid metabolism in the development of Lipotoxicity and type 2 diabetes
- Lipotoxicity and β Cell Maintenance in Obesity and Type 2 Diabetes
- Adipogenesis and Lipotoxicity: role of peroxisome proliferator-activated receptor γ (PPARγ) and PPARγcoactivator-1 (PGC1)
- Molecular mechanisms of human lipodystrophies: from adipocyte lipid droplet to oxidative stress and Lipotoxicity
- The adaptive endoplasmic reticulum stress response to Lipotoxicity in progressive human nonalcoholic fatty liver disease
- Lipotoxicity in diabetic nephropathy: the potential role of fatty acid oxidation
- The role of Lipotoxicity in smoke cardiomyopathy
- Beta-cell Lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: impairment in adipocyte-beta-cell relationships.
- Lipotoxicity disrupts incretin-regulated human β cell connectivity
- The sensitivity of pancreatic β-cells to mitochondrial injuries triggered by Lipotoxicity and oxidative stress
- Lipid droplets and Lipotoxicity during autophagy
- SIRT3 is regulated by nutrient excess and modulates hepatic susceptibility to Lipotoxicity
- Lipotoxicity augments glucotoxicity-induced mitochondrial damage in the development of diabetic retinopathy
- Lipotoxicity plays a key role in the development of both insulin resistance and muscle atrophy in patients with type 2 diabetes
- Central ceramide-induced hypothalamic Lipotoxicity and ER stress regulate energy balance
- A mouse model reveals an important role for catecholamine‐induced Lipotoxicity in the pathogenesis of stress‐induced cardiomyopathy
- Longevity, Lipotoxicity and leptin: the adipocyte defense against feasting and famine
- Adverse physicochemical properties of tripalmitin in beta cells lead to morphological changes and Lipotoxicity in vitro
- Inhibition of fatty acid biosynthesis prevents adipocyte Lipotoxicity on human osteoblasts in vitro
- Lipotoxicity, fatty acid uncoupling and mitochondrial carrier function
- Deleterious action of FA metabolites on ATP synthesis: possible link between Lipotoxicity, mitochondrial dysfunction, and insulin resistance
- Polycystic ovary syndrome: impact of Lipotoxicity on metabolic and reproductive health
- Lipotoxicity, aging, and muscle contractility: does fiber type matter?
- An essential requirement for the SCAP/SREBP signaling axis to protect cancer cells from Lipotoxicity
- Ventricular assist device implantation corrects myocardial Lipotoxicity, reverses insulin resistance, and normalizes cardiac metabolism in patients with advanced heart …
- Blueberry metabolites attenuate Lipotoxicity‐induced endothelial dysfunction
- The impact of triglycerides on glucose tolerance: Lipotoxicity revisited
- Time‐course changes of muscle protein synthesis associated with obesity‐induced Lipotoxicity
- Lipotoxicity: the obese and endurance-trained paradox
- Evidence for altered thiamine metabolism in diabetes: Is there a potential to oppose gluco-and Lipotoxicity by rational supplementation?
- Aging results in paradoxical susceptibility of fat cell progenitors to Lipotoxicity
- Prevention of free fatty acid–induced hepatic Lipotoxicity by 18β‐glycyrrhetinic acid through lysosomal and mitochondrial pathways
- Soy protein reduces hepatic Lipotoxicity in hyperinsulinemic obese Zucker fa/fa rats
- Hyperglycemia magnifies Schwann cell dysfunction and cell death triggered by PA-induced Lipotoxicity
- Lipotoxicity of the pancreatic β-cell is associated with glucose-dependent esterification of fatty acids into neutral lipids
- Hepatocyte free cholesterol Lipotoxicity results from JNK1-mediated mitochondrial injury and is HMGB1 and TLR4-dependent
- ER calcium release promotes mitochondrial dysfunction and hepatic cell Lipotoxicity in response to palmitate overload
- The role of autophagy in β‐cell Lipotoxicity and type 2 diabetes
- Lipotoxicity and steatohepatitis in an overfed mouse model for non-alcoholic fatty liver disease
- Differential lipid partitioning between adipocytes and tissue macrophages modulates macrophage Lipotoxicity and M2/M1 polarization in obese mice
- Myocardial lipid accumulation and Lipotoxicity in heart failure 1
- Induction of stearoyl-CoA desaturase protects human arterial endothelial cells against Lipotoxicity
- Lipotoxicity and impaired high density lipoprotein-mediated reverse cholesterol transport in chronic kidney disease
- Drug-induced Lipotoxicity: lipodystrophy associated with HIV-1 infection and antiretroviral treatment
- The role of cardiac Lipotoxicity in the pathogenesis of diabetic cardiomyopathy
- Alteration of endoplasmic reticulum lipid rafts contributes to Lipotoxicity in pancreatic β-cells
- Fetuin A promotes Lipotoxicity in β cells through the TLR4 signaling pathway and the role of pioglitazone in anti-Lipotoxicity
- Carnitine palmitoyltransferase-1b deficiency aggravates pressure overload–induced cardiac hypertrophy caused by Lipotoxicity
- Origins of metabolic complications in obesity: ectopic fat accumulation. The importance of the qualitative aspect of Lipotoxicity
- Reducing VEGF-B signaling ameliorates renal Lipotoxicity and protects against diabetic kidney disease
- Sab (Sh3bp5) dependence of JNK mediated inhibition of mitochondrial respiration in palmitic acid induced hepatocyte Lipotoxicity
- DHA at nutritional doses restores insulin sensitivity in skeletal muscle by preventing Lipotoxicity and inflammation
- Mechanisms in endocrinology: skeletal muscle Lipotoxicity in insulin resistance and type 2 diabetes: a causal mechanism or an innocent bystander?
- Overfeeding-induced ovarian dysfunction in broiler breeder hens is associated with Lipotoxicity
- ATF6α downregulation of PPARα promotes Lipotoxicity-induced tubulointerstitial fibrosis
- CD36 as a target to prevent cardiac Lipotoxicity and insulin resistance
- Hypoxic signaling and cholesterol Lipotoxicity in fatty liver disease progression
- Adiponectin receptor agonist AdipoRon decreased ceramide, and Lipotoxicity, and ameliorated diabetic nephropathy
- Toll-like receptor, Lipotoxicity and chronic inflammation: the pathological link between obesity and cardiometabolic disease
- Lipotoxicity and cardiac dysfunction in mammals and Drosophila
- Glutamine modulates macrophage Lipotoxicity
- Enhanced synthesis of saturated phospholipids is associated with ER stress and Lipotoxicity in palmitate treated hepatic cells [S]
- Acute Lipotoxicity regulates severity of biliary acute pancreatitis without affecting its initiation
- Current views of the fat cell as an endocrine cell: Lipotoxicity
- Apolipoprotein O is mitochondrial and promotes Lipotoxicity in heart
- Lipotoxicity in renal proximal tubular cells: relationship between endoplasmic reticulum stress and oxidative stress pathways
- Resveratrol prevents renal Lipotoxicity and inhibits mesangial cell glucotoxicity in a manner dependent on the AMPK–SIRT1–PGC1α axis in db/db mice
- High-fat diet-induced juvenile obesity leads to cardiomyocyte dysfunction and upregulation of Foxo3a transcription factor independent of Lipotoxicity and apoptosis
- Vascular Lipotoxicity: endothelial dysfunction via fatty-acid-induced reactive oxygen species overproduction in obese Zucker diabetic fatty rats
- Doxorubicin treatment inhibits PPARγ and may induce Lipotoxicity by mimicking a type 2 diabetes-like condition in rodent models
- Sphingolipid metabolism: new insight into ceramide-induced Lipotoxicity in muscle cells
- Metabolic mechanisms of failure of intraportally transplanted pancreatic β-cells in rats: role of Lipotoxicity and prevention by leptin
- Shedding light on the enigma of myocardial Lipotoxicity: the involvement of known and putative regulators of fatty acid storage and mobilization
- Lipotoxicity, a potential risk factor for the increasing prevalence of subclinical hypothyroidism?
- Oleic acid protects saturated fatty acid mediated Lipotoxicity in hepatocytes and rat of non-alcoholic steatohepatitis
- Avocatin B Protects Against Lipotoxicity and Improves Insulin Sensitivity in Diet‐Induced Obesity
- Short-term selective alleviation of glucotoxicity and Lipotoxicity ameliorates the suppressed expression of key β-cell factors under diabetic conditions
- Autophagy couteracts weight gain, Lipotoxicity and pancreatic β-cell death upon hypercaloric pro-diabetic regimens
- Vascular metabolic dysfunction and Lipotoxicity.
- Intergenerational inheritance of high fat diet-induced cardiac Lipotoxicity in Drosophila
- Fenofibrate Improves Renal Lipotoxicity through Activation of AMPK-PGC-1α in db/db Mice
- Mechanisms of palmitate-induced Lipotoxicity in osteocytes
- Role of cardiac steatosis and Lipotoxicity in obesity cardiomyopathy
- Lysosome acidification by photoactivated nanoparticles restores autophagy under Lipotoxicity
- Lipotoxicity and the development of heart failure: moving from mouse to man
- Targeting bile acids and Lipotoxicity for NASH treatment
- Sequestration of fatty acids in triglycerides prevents endoplasmic reticulum stress in an in vitro model of cardiomyocyte Lipotoxicity
- High-fat diet-mediated Lipotoxicity and insulin resistance is related to impaired lipase expression in mouse skeletal muscle
- Renal Lipotoxicity-associated inflammation and insulin resistance affects actin cytoskeleton organization in podocytes
- Exercise counteracts Lipotoxicity by improving lipid turnover and lipid droplet quality
- PPAR/RXR regulation of fatty acid metabolism and fatty acid ω-hydroxylase (CYP4) isozymes: implications for prevention of Lipotoxicity in fatty liver disease
- Substrate cycling between de novo lipogenesis and lipid oxidation: a thermogenic mechanism against skeletal muscle Lipotoxicity and glucoLipotoxicity
- Cardiac diastolic dysfunction in high-fat diet fed mice is associated with Lipotoxicity without impairment of cardiac energetics in vivo
- Palmitate-induced Lipotoxicity is crucial for the pathogenesis of nonalcoholic fatty liver disease in cooperation with gut-derived endotoxin
- Sleep apnea: An overlooked cause of Lipotoxicity?
- Skeletal muscle damage and impaired regeneration due to LPL-mediated Lipotoxicity
- Mechanism underlying oxidative stress-mediated Lipotoxicity: exposure of J774. 2 macrophages to triacylglycerols facilitates mitochondrial reactive oxygen species …
- Epigallocatechin gallate improves insulin resistance in HepG2 cells through alleviating inflammation and Lipotoxicity
- AKR1C3-mediated adipose androgen generation drives Lipotoxicity in women with polycystic ovary syndrome
- An inducible ER–Golgi tether facilitates ceramide transport to alleviate Lipotoxicity
- Systematic evaluation of phenolic compounds and protective capacity of a new mulberry cultivar J33 against palmitic acid-induced Lipotoxicity using a simulated …
- Engineered FGF19 eliminates bile acid toxicity and Lipotoxicity leading to resolution of steatohepatitis and fibrosis in mice
- Antagonism between saturated and unsaturated fatty acids in ROS mediated Lipotoxicity in rat insulin-producing cells
- Thematic review series: Lipotoxicity: Many roads to cell dysfunction and cell death: Lipotoxic lethal and sublethal stress signaling in hepatocytes: Relevance to …
- DGAT1 deficiency decreases PPAR expression and does not lead to Lipotoxicity in cardiac and skeletal muscle [S]
- Akkermansia muciniphila can reduce the damage of gluco/Lipotoxicity, oxidative stress and inflammation, and normalize intestine microbiota in streptozotocin-induced …
- The cumulus cell layer protects the bovine maturing oocyte against fatty acid-induced Lipotoxicity
- Roles of sphingolipid metabolism in pancreatic β cell dysfunction induced by Lipotoxicity
- Cardiac-specific ablation of ARNT leads to Lipotoxicity and cardiomyopathy
- The nuclear receptor FXR is expressed in pancreatic β-cells and protects human islets from Lipotoxicity
- Ghrelin attenuated Lipotoxicity via autophagy induction and nuclear factor-κB inhibition
- Lipotoxicity induces hepatic protein inclusions through TANK binding kinase 1–mediated p62/sequestosome 1 phosphorylation
- Perilipin5 protects against Lipotoxicity and alleviates endoplasmic reticulum stress in pancreatic β-cells
- Lipotoxicity of palmitic acid on neural progenitor cells and hippocampal neurogenesis
- Sorcin Links Pancreatic β-Cell Lipotoxicity to ER Ca2+ Stores
- Activation and reversal of Lipotoxicity in PC12 and rat cortical cells following exposure to palmitic acid
- Gene and protein kinase expression profiling of reactive oxygen species-associated Lipotoxicity in the pancreatic β-cell line MIN6
- High-density lipoprotein ameliorates palmitic acid-induced Lipotoxicity and oxidative dysfunction in H9c2 cardiomyoblast cells via ROS suppression
- Obese and anorexic yeasts: experimental models to understand the metabolic syndrome and Lipotoxicity
- The role of lipid droplet formation in the protection of unsaturated fatty acids against palmitic acid induced Lipotoxicity to rat insulin-producing cells
- Metabolomic strategies to study Lipotoxicity in cardiovascular disease
- Peroxisome proliferator–activated receptor α improves pancreatic adaptation to insulin resistance in obese mice and reduces Lipotoxicity in human islets
- Mitochondrial protein phosphorylation: instigator or target of Lipotoxicity?
- Prevention of free fatty acid-induced hepatic Lipotoxicity in HepG2 cells by magnesium isoglycyrrhizinate in vitro
- … proliferator–activated receptor-α gene expression in a mouse model of ischemic cardiomyopathy is dependent on reactive oxygen species and prevents Lipotoxicity
- Role of hepatocyte S6K1 in palmitic acid-induced endoplasmic reticulum stress, Lipotoxicity, insulin resistance and in oleic acid-induced protection
- Prevention and reversal of Lipotoxicity-induced hepatic insulin resistance and steatohepatitis in mice by an antioxidant carotenoid, β-cryptoxanthin
- Loss of biliverdin reductase-A promotes lipid accumulation and Lipotoxicity in mouse proximal tubule cells
- Impaired fatty acid oxidation as a cause for Lipotoxicity in cardiomyocytes
- Decoration of intramyocellular lipid droplets with PLIN5 modulates fasting-induced insulin resistance and Lipotoxicity in humans
- Pancreatic β-cell Lipotoxicity induced by overexpression of hormone-sensitive lipase
- Myristic acid potentiates palmitic acid-induced Lipotoxicity and steatohepatitis associated with lipodystrophy by sustaning de novo ceramide synthesis
- Lipotoxicity versus adipotoxicity—the deleterious effects of adipose tissue on beta cells in the pathogenesis of type 2 diabetes
- Liposomal prednisolone promotes macrophage Lipotoxicity in experimental atherosclerosis
- Cardiomyocyte Lipotoxicity is mediated by Il-6 and causes down-regulation of PPARs
- Low citrate synthase activity is associated with glucose intolerance and Lipotoxicity
- New mechanism of Lipotoxicity in diabetic cardiomyopathy: Deficiency of Endogenous H2S Production and ER stress
- … peroxisome proliferator–activated receptor‐delta agonist seladelpar reverses nonalcoholic steatohepatitis pathology by abrogating Lipotoxicity in diabetic obese mice
- Lysophosphatidylcholines activate PPARδ and protect human skeletal muscle cells from Lipotoxicity
- Disruption of calpain reduces Lipotoxicity-induced cardiac injury by preventing endoplasmic reticulum stress
- Prevention of free fatty acid‐induced hepatic Lipotoxicity by carnitine via reversal of mitochondrial dysfunction
- Limited mitochondrial permeabilization is an early manifestation of palmitate-induced Lipotoxicity in pancreatic β-cells
- Anthocyanin-rich Seoritae extract ameliorates renal Lipotoxicity via activation of AMP-activated protein kinase in diabetic mice
- Unbalanced lipolysis results in Lipotoxicity and mitochondrial damage in peroxisome-deficient Pex19 mutants
- Nonalcoholic fatty liver disease (NAFLD) and cardiac Lipotoxicity: Another piece of the puzzle
- The role of fatty acid metabolism and Lipotoxicity in pancreatic β-cell injury: identification of potential therapeutic targets
- Dissociation of Lipotoxicity and glucotoxicity in a mouse model of obesity associated diabetes: role of forkhead box O1 (FOXO1) in glucose-induced beta cell …
- Interruption of triacylglycerol synthesis in the endoplasmic reticulum is the initiating event for saturated fatty acid‐induced Lipotoxicity in liver cells
- Lipotoxicity in obesity: Benefit of olive oil
- α-Linolenic acid prevents endoplasmic reticulum stress-mediated apoptosis of stearic acid Lipotoxicity on primary rat hepatocytes
- tert-Butylhydroquinone (tBHQ) protects hepatocytes against Lipotoxicity via inducing autophagy independently of Nrf2 activation
- Mechanisms Involved in the Improvement of Lipotoxicity and Impaired Lipid Metabolism by Dietary α-Linolenic Acid Rich Salvia hispanica L (Salba) Seed in the …
- N− 3PUFA differentially modulate palmitate-induced Lipotoxicity through alterations of its metabolism in C2C12 muscle cells
- Punicalagin attenuates palmitate‐induced Lipotoxicity in HepG2 cells by activating the Keap1‐Nrf2 antioxidant defense system
- The impairment of glucose-stimulated insulin secretion in pancreatic β-cells caused by prolonged glucotoxicity and Lipotoxicity is associated with elevated adaptive …
- Glucose fluctuation increased hepatocyte apoptosis under Lipotoxicity and the involvement of mitochondrial permeability transition opening
- The impact of cardiac Lipotoxicity on cardiac function and mirnas signature in obese and non-obese rats with myocardial infarction
- α-Linolenic acid protects renal cells against palmitic acid Lipotoxicity via inhibition of endoplasmic reticulum stress
- Saturated phosphatidic acids mediate saturated fatty acid–induced vascular calcification and Lipotoxicity
- Grape seed and skin extract prevents high-fat diet-induced brain Lipotoxicity in rat
- Drosophila as a Lipotoxicity model organism—more than a promise?
- Dietary rescue of Lipotoxicity-induced mitochondrial damage in Peroxin19 mutants
- Myocardial fatty acid metabolism and Lipotoxicity in the setting of insulin resistance
- Early PQQ supplementation has persistent long-term protective effects on developmental programming of hepatic Lipotoxicity and inflammation in obese mice
- Non-parenchymal hepatic cell Lipotoxicity and the coordinated progression of non-alcoholic fatty liver disease and atherosclerosis
- Interaction between maternal and postnatal high fat diet leads to a greater risk of myocardial dysfunction in offspring via enhanced Lipotoxicity, IRS-1 serine …
- Lack of Lipotoxicity effect on β-cell dysfunction in ketosis-prone type 2 diabetes
- Aryl hydrocarbon receptor plays protective roles against high fat diet (HFD)-induced hepatic steatosis and the subsequent Lipotoxicity via direct transcriptional …
- Protection of palmitic acid-mediated Lipotoxicity by arachidonic acid via channeling of palmitic acid into triglycerides in C2C12
- Who pulls the trigger: JNK activation in liver Lipotoxicity?
- Common medications which lead to unintended alterations in weight gain or organ Lipotoxicity
- GCN2 deficiency ameliorates cardiac dysfunction in diabetic mice by reducing Lipotoxicity and oxidative stress
- Dietary fiber prevents obesity-related liver Lipotoxicity by modulating sterol-regulatory element binding protein pathway in C57BL/6J mice fed a high-fat …
- Fatal “Triad”: Lipotoxicity, oxidative stress, and phenoptosis
- Nicotinamide protects hepatocytes against palmitate-induced Lipotoxicity via SIRT1-dependent autophagy induction
- The effect of Lipotoxicity on renal dysfunction in a nonobese rat model of metabolic syndrome: a urinary proteomic approach
- Lipotoxicity and the role of maternal nutrition
- M2 macrophages exhibit higher sensitivity to oxLDL-induced Lipotoxicity than other monocyte/macrophage subtypes
- Ghrelin inhibits cell apoptosis induced by Lipotoxicity in pancreatic β-cell line
- Lipotoxicity-mediated cell dysfunction and death involve lysosomal membrane permeabilization and cathepsin L activity
- Palmitic acid-induced Lipotoxicity and protection by (+)-catechin in rat cortical astrocytes
- Oleate abrogates palmitate-induced Lipotoxicity and proinflammatory response in human bone marrow-derived mesenchymal stem cells and osteoblastic cells
- Effect of α-linolenic acid on endoplasmic reticulum stress-mediated apoptosis of palmitic acid Lipotoxicity in primary rat hepatocytes
- Attenuation of palmitic acid–induced Lipotoxicity by chlorogenic acid through activation of SIRT1 in hepatocytes
- Hepatic FTO expression is increased in NASH and its silencing attenuates palmitic acid-induced Lipotoxicity
- FFAs-ROS-ERK/P38 pathway plays a key role in adipocyte Lipotoxicity on osteoblasts in co-culture
- Polysaccharide from Mulberry Fruit (Morus alba L.) Protects against Palmitic-Acid-Induced Hepatocyte Lipotoxicity by Activating the Nrf2/ARE Signaling Pathway
- Lipotoxicity is glucose-dependent in INS-1E cells but not in human islets and MIN6 cells
- Lipotoxicity and kidney
- Altered glutathione homeostasis in heart augments cardiac Lipotoxicity associated with diet-induced obesity in mice
- Tributyltin exposure causes Lipotoxicity responses in the ovaries of rockfish, Sebastiscus marmoratus
- Prolonged exposure to high dietary lipids is not associated with Lipotoxicity in heart failure
- Osteonecrosis of the femoral head: Lipotoxicity exacerbation in MSC and modifications of the bone marrow fluid
- Switching obese mothers to a healthy diet improves fetal hypoxemia, hepatic metabolites, and Lipotoxicity in non-human primates
- Attenuated Lipotoxicity and apoptosis is linked to exogenous and endogenous augmenter of liver regeneration by different pathways
- Skeletal muscle Lipotoxicity in insulin resistance and type 2 diabetes
- Nanoparticle‐mediated lysosomal reacidification restores mitochondrial turnover and function in β cells under Lipotoxicity
- … released from fat-laden cells promote activation of hepatocellular NLRP3 inflammasome: A pro-inflammatory link between Lipotoxicity and non-alcoholic …
- Stearic acid at physiologic concentrations induces in vitro Lipotoxicity in circulating angiogenic cells
- Palmitate-induced Lipotoxicity alters acetylation of multiple proteins in clonal β cells and human pancreatic islets
- Insulin resistance in African-American and Caucasian women: differences in Lipotoxicity, adipokines, and gene expression in adipose tissue and muscle
- Chronic activation of liver X receptor induces β-cell apoptosis through hyperactivation of lipogenesis: liver X receptor–mediated Lipotoxicity in pancreatic β-cells
- ER-resident antioxidative GPx7 and GPx8 enzyme isoforms protect insulin-secreting INS-1E β-cells against Lipotoxicity by improving the ER antioxidative capacity
- Advanced Oxidation Protein Products Promote Lipotoxicity and Tubulointerstitial Fibrosis via CD36/β-Catenin Pathway in Diabetic Nephropathy
- Antioxidant and anti-inflammatory effects of Chinese propolis during palmitic acid-induced Lipotoxicity in cultured hepatocytes
- Eicosapentaenoic acid protects cardiomyoblasts from Lipotoxicity in an autophagy-dependent manner
- Thematic Review Series: Lipotoxicity: Many Roads to Cell Dysfunction and Cell Death: Lipid signaling and Lipotoxicity in metaflammation: indications for …
- Podocyte Lipotoxicity in diabetic kidney disease
- The critical role of astragalus polysaccharides for the improvement of ppraα-mediated Lipotoxicity in diabetic cardiomyopathy
- Macrophage alternative activation confers protection against Lipotoxicity-induced cell death
- Ceramide dependent Lipotoxicity in metabolic diseases
- Chamomile (Matricaria recutita L.) decoction extract inhibits in vitro intestinal glucose absorption and attenuates high fat diet-induced Lipotoxicity and oxidative stress
- Involvement of iron depletion in palmitate-induced Lipotoxicity of beta cells
- Diacylglycerol triggers Rim101 pathway–dependent necrosis in yeast: a model for Lipotoxicity
- Temporal proteomic analysis of pancreatic β-cells in response to Lipotoxicity and glucoLipotoxicity
- Precision toxicology shows that troxerutin alleviates ochratoxin A–induced renal Lipotoxicity
- Peroxisome proliferator-activated receptor-α activator fenofibrate prevents high-fat diet-induced renal Lipotoxicity in spontaneously hypertensive rats
- JunB protects β-cells from Lipotoxicity via the XBP1–AKT pathway
- Angiotensin 1–7 Ameliorates Diabetic Cardiomyopathy and Diastolic Dysfunction in db/db Mice by Reducing Lipotoxicity and Inflammation
- Deep fried edible oils disturb hepatic redox equilibrium and heightens Lipotoxicity and hepatosteatosis in male Wistar rats
- Attenuated lymphatic proliferation ameliorates diabetic nephropathy and high-fat diet-induced renal Lipotoxicity
- Activation of AMP-activated protein kinase prevents Lipotoxicity in retinal pericytes
- Global analyses of selective insulin resistance in hepatocytes caused by palmitate Lipotoxicity
- Dietary fat-associated osteoarthritic chondrocytes gain resistance to Lipotoxicity through PKCK2/STAMP2/FSP27
- Future directions in reducing hepatic Lipotoxicity
- Resveratrol prevents renal Lipotoxicity in high-fat diet-treated mouse model through regulating PPAR-α pathway
- Activation of sterol-response element-binding proteins (SREBP) in alveolar type II cells enhances lipogenesis causing pulmonary Lipotoxicity
- Higd1a protects cells from Lipotoxicity under high-fat exposure
- Polysaccharide from Rubus chingii Hu affords protection against palmitic acid-induced Lipotoxicity in human hepatocytes
- The p66Shc redox adaptor protein is induced by saturated fatty acids and mediates Lipotoxicity-induced apoptosis in pancreatic beta cells
- Grape seed and skin extract reduces pancreas Lipotoxicity, oxidative stress and inflammation in high fat diet fed rats
- Effects of Lipotoxicity on a novel insulin-secreting human pancreatic β-cell line, 1.1 B4
- Hepatocyte growth factor reduces free cholesterol-mediated Lipotoxicity in primary hepatocytes by countering oxidative stress
- RNA regulation of Lipotoxicity and metabolic stress
- The relationship between GPR40 and Lipotoxicity of the pancreatic β-cells as well as the effect of pioglitazone
- Wogonin ameliorates Lipotoxicity-induced apoptosis of cultured vascular smooth muscle cells via interfering with DAG-PKC pathway
- Inhibition of ghrelin o-acyltransferase attenuated Lipotoxicity by inducing autophagy via AMPK–mTOR pathway
- Insulin resistance caused by Lipotoxicity is related to oxidative stress and endoplasmic reticulum stress in LPL gene knockout heterozygous mice
- Protective potentials of wild rice (Zizania latifolia (Griseb) Turcz) against obesity and Lipotoxicity induced by a high-fat/cholesterol diet in rats
- Lipotoxicity: what is the fate of fatty acids? 1
- Niacin receptor activation improves human microvascular endothelial cell angiogenic function during Lipotoxicity
- Uncoupled respiration, ROS production, acute Lipotoxicity and oxidative damage in isolated skeletal muscle mitochondria from UCP3-ablated mice
- Nutrigenomics as a tool in the prevention of Lipotoxicity: the case of soy protein
- Adenosine A2a receptor stimulation prevents hepatocyte Lipotoxicity and non-alcoholic steatohepatitis (NASH) in rats
- Lotus seedpod extracts reduced lipid accumulation and Lipotoxicity in hepatocytes
- Increased plasma levels of the lipoperoxyl radical-derived vitamin E metabolite α-tocopheryl quinone are an early indicator of Lipotoxicity in fatty liver subjects
- Palmitic acid-induced Lipotoxicity promotes a novel interplay between Akt-mTOR, IRS-1, and FFAR1 signaling in pancreatic β-cells
- Glucotoxicity and Lipotoxicity: Factors in the pathogenesis and evolution of type 2 diabetes
- Differential impact of acute and chronic Lipotoxicity on gene expression in INS-1 cells
- GPR120 protects Lipotoxicity-induced pancreatic β-cell dysfunction through regulation of PDX1 expression and inhibition of islet inflammation
- Inhibition of long-chain acyl coenzyme A synthetases during fatty acid loading induces Lipotoxicity in macrophages
- Concerted action of p62 and Nrf2 protects cells from palmitic acid-induced Lipotoxicity
- Royal jelly supplementation reduces skeletal muscle Lipotoxicity and insulin resistance in aged obese rats
- Lipotoxicity and decreased islet graft survival
- Stagnation of autophagy: A novel mechanism of renal Lipotoxicity
- Ghrelin inhibits insulin resistance induced by glucotoxicity and Lipotoxicity in cardiomyocyte
- NDRG2 is highly expressed in pancreatic β cells and involved in protection against Lipotoxicity
- Caveolins/caveolae protect adipocytes from fatty acid-mediated Lipotoxicity
- Minireview: secondary β-cell failure in type 2 diabetes—a convergence of glucotoxicity and Lipotoxicity
- A systems biology analysis of brain microvascular endothelial cell Lipotoxicity
- Loss of ULK1 increases RPS6KB1-NCOR1 repression of NR1H/LXR-mediated Scd1 transcription and augments Lipotoxicity in hepatic cells
- The effect of isosteviol on hyperglycemia and dyslipidemia induced by Lipotoxicity in rats fed with high-fat emulsion
- Glutamate–oxaloacetate transaminase activity promotes palmitate Lipotoxicity in rat hepatocytes by enhancing anaplerosis and citric acid cycle flux
- Ubiquitous transcription factor YY1 promotes zebrafish liver steatosis and Lipotoxicity by inhibiting CHOP-10 expression
- Lipotoxicity pathways intersect in hepatocytes: Endoplasmic reticulum stress, c‐Jun N‐terminal kinase‐1, and death receptors
- Repositioning of niclosamide ethanolamine (NEN), an anthelmintic drug, for the treatment of Lipotoxicity
- Oleic acid protects insulin-secreting INS-1E cells against palmitic acid-induced Lipotoxicity along with an amelioration of ER stress
- Ursolic acid protects hepatocytes against Lipotoxicity through activating autophagy via an AMPK pathway
- Long-term treatment with nicotinamide induces glucose intolerance and skeletal muscle Lipotoxicity in normal chow-fed mice: compared to diet-induced obesity
- … of repressive cAMP response element modulators in high glucose and fatty acid-treated rat islets: a common mechanism for glucose toxicity and Lipotoxicity?
- Lipotoxicity-induced PRMT1 exacerbates mesangial cell apoptosis via endoplasmic reticulum stress
- A novel function of bamboo extract in relieving Lipotoxicity
- Cytoprotective effect of hispidin against palmitate-induced Lipotoxicity in C2C12 myotubes
- Hepatoprotective and antioxidant activities of oil from baru almonds (Dipteryx alata Vog.) in a preclinical model of Lipotoxicity and dyslipidemia
- ER stress attenuation by Aloe-derived polysaccharides in the protection of pancreatic β-cells from free fatty acid-induced Lipotoxicity
- Molecular mechanisms of Lipotoxicity in nonalcoholic fatty liver disease
- Lipotoxicity, β cell dysfunction, and gestational diabetes
- The nuclear orphan receptor Nur77 is a Lipotoxicity sensor regulating glucose-induced insulin secretion in pancreatic β-cells
- AMPK activation as a strategy for reversing the endothelial Lipotoxicity underlying the increased vascular risk associated with insulin resistance syndrome
- Glucotoxicity and Lipotoxicity induced beta-cell apoptosis in type 2 diabetes mellitus
- Protein kinase B/Akt signalling is required for palmitate‐induced β‐cell Lipotoxicity
- Brain Lipotoxicity of phytanic acid and very long-chain fatty acids. Harmful cellular/mitochondrial activities in Refsum disease and X-linked …
- β-cell Lipotoxicity: burning fat into heat?
- Dichotomous roles of leptin and adiponectin as enforcers against Lipotoxicity during feast and famine
- Atrial fibrillation in patients admitted to coronary care units in western Sweden–focus on obesity and Lipotoxicity
- Ketone Body Therapy Protects From Lipotoxicity and Acute Liver Failure Upon Pparα Deficiency
- Caveolins sequester FA on the cytoplasmic leaflet of the plasma membrane, augment triglyceride formation, and protect cells from Lipotoxicity
- … to fatty acid-induced β-cell dysfunction is enhanced in prediabetic diabetes-prone biobreeding rats: a potential link between β-cell Lipotoxicity and islet inflammation
- Hypericin maintians PDX1 expression via the Erk pathway and protects islet β-cells against glucotoxicity and Lipotoxicity
- Inhibition of Foxo1 mediates protective effects of ghrelin against Lipotoxicity in MIN6 pancreatic β-cells
- Antagonistic effects of thiazolidinediones and cytokines in Lipotoxicity
- Fatty old hearts: role of cardiac Lipotoxicity in age-related cardiomyopathy
- Protective effects of arachidonic acid against palmitic acid-mediated Lipotoxicity in HIT-T15 cells
- Lipotoxicity reduces β cell survival through islet stellate cell activation regulated by lipid metabolism-related molecules
- Lipotoxicity impairs incretin signalling
- Oligonol, a low-molecular-weight polyphenol derived from lychee fruit, attenuates gluco-Lipotoxicity-mediated renal disorder in type 2 diabetic db/db mice
- Intra-islet PACAP protects pancreatic β-cells against glucotoxicity and Lipotoxicity
- Astragalus polysaccharides repress myocardial Lipotoxicity in a PPARalpha-dependent manner in vitro and in vivo in mice
- Eucommia ulmoides Cortex, Geniposide and Aucubin Regulate Lipotoxicity through the Inhibition of Lysosomal BAX
- Increased body fat mass and tissue Lipotoxicity associated with ovariectomy or high-fat diet differentially affects bone and skeletal muscle metabolism in rats
- Involvement of UCP3 in mild uncoupling and Lipotoxicity
- Silymarin prevents palmitate‐induced Lipotoxicity in HepG2 cells: involvement of maintenance of Akt kinase activation
- Grape seed and skin extract alleviates high-fat diet-induced renal Lipotoxicity and prevents copper depletion in rat
- Fatty acid metabolism and Lipotoxicity in the pathogenesis of NAFLD/NASH
- Ceramide accumulation and up-regulation of proinflammatory interleukin-1β exemplify Lipotoxicity to mediate declines of reproductive efficacy of broiler hens
- Grape seed and skin extract as an adjunct to xenical therapy reduces obesity, brain Lipotoxicity and oxidative stress in high fat diet fed rats
- Lipotoxicity on the basis of metabolic syndrome and lipodystrophy in HIV-1-infected patients under antiretroviral treatment
- Palmitic acid induced Lipotoxicity is associated with altered lipid metabolism, enhanced CYP450 2E1 and intracellular calcium mediated ER stress in human hepatoma …
- Protective effects of grape seed and skin extract against high-fat-diet-induced Lipotoxicity in rat lung
- Loss of c-Met signaling sensitizes hepatocytes to Lipotoxicity and induces cholestatic liver damage by aggravating oxidative stress
- PGC-1/spargel counteracts high-fat-diet-induced obesity and cardiac Lipotoxicity downstream of TOR and brummer ATGL lipase
- Coriandrum sativum L. seed extract mitigates Lipotoxicity in RAW 264.7 cells and prevents atherogenic changes in rats
- PHYSIOLOGY AND ENDOCRINOLOGY SYMPOSIUM: Insulin action and Lipotoxicity in the development of polycystic ovary syndrome: A review
- Lipid droplet formation protects against gluco/Lipotoxicity in Candida parapsilosis: An essential role of fatty acid desaturase Ole1
- Stearoyl-CoA desaturase-1 protects cells against Lipotoxicity-mediated apoptosis in proximal tubular cells
- PPAR gamma 2 prevents Lipotoxicity by controlling adipose tissue expandability and peripheral lipid metabolism
- Anatomical fat distribution and accumulation and Lipotoxicity in lean and obese pregnancy
- Glucagon-like peptide 1 decreases Lipotoxicity in non-alcoholic steatohepatitis
- The flavoheme reductase Ncb5or protects cells against endoplasmic reticulum stress-induced Lipotoxicity [S]
- Knockdown of triglyceride synthesis does not enhance palmitate Lipotoxicity or prevent oleate-mediated rescue in rat hepatocytes
- Perilipin is present in islets of Langerhans and protects against Lipotoxicity when overexpressed in the β-cell line INS-1
- Glucotoxicity and Lipotoxicity in the beta cell
- Maternal obesity stimulates Lipotoxicity and up‐regulates inflammatory signaling pathways in the full‐term swine placenta
- Effects of Garcinia cambogia extract on the adipogenic differentiation and Lipotoxicity
- Protective effect of docosahexaenoic acid on Lipotoxicity‐mediated cell death in Schwann cells: Implication of PI3K/AKT and mTORC2 pathways
- Food-drug interaction: Anabolic steroids aggravate hepatic Lipotoxicity and nonalcoholic fatty liver disease induced by trans fatty acids
- Polyacetylene glycoside attenuates ischemic kidney injury by co-inhibiting inflammation, mitochondria dysfunction and Lipotoxicity
- Protection of human pancreatic islets from Lipotoxicity by modulation of the translocon
- Stable isotope-labeled lipidomics to unravel the heterogeneous development Lipotoxicity
- Long-chain metabolites of vitamin E: Interference with Lipotoxicity via lipid droplet associated protein PLIN2
- Eicosapentaenoic acid ameliorates palmitate-induced Lipotoxicity via the AMP kinase/dynamin-related protein-1 signaling pathway in differentiated H9c2 myocytes
- Perilipin 5 improves hepatic Lipotoxicity by inhibiting lipolysis
- Fibroblast growth factor 21 protects against Lipotoxicity-induced pancreatic β-cell dysfunction via regulation of AMPK signaling and lipid metabolism
- Beyond reasonable doubt: who is the culprit in Lipotoxicity in NAFLD/NASH?
- Molecular regulation of Lipotoxicity in the heart
- Shared biochemical properties of glucotoxicity and Lipotoxicity in islets decrease citrate synthase activity and increase phosphofructokinase activity.
- Effects of biotin on glucotoxicity or Lipotoxicity in rat pancreatic islets
- Systems biology strategy to study Lipotoxicity and the metabolic syndrome
- Chemical chaperone 4-phenyl butyric acid (4-PBA) reduces hepatocellular lipid accumulation and Lipotoxicity through induction of autophagy [S]
- The role of CCAAT enhancer‐binding protein homologous protein in human immunodeficiency virus protease‐inhibitor–induced hepatic Lipotoxicity in mice
- Lipotoxicity in cardiac and skeletal muscle
- Adipokines promote Lipotoxicity in human skeletal muscle cells
- Sterol regulatory element‐binding protein‐1c knockdown protected INS‐1E cells from Lipotoxicity
- TRB3 stimulates SIRT1 degradation and induces insulin resistance by Lipotoxicity via COP1
- MicroRNA-451 exacerbates Lipotoxicity in cardiac myocytes and high-fat diet-induced cardiac hypertrophy in mice through suppression of the LKB1/AMPK pathway
- Fibroblast growth factor 21 limits Lipotoxicity by promoting hepatic fatty acid activation in mice on methionine and choline-deficient diets
- Intramuscular adipocytes-potential to prevent Lipotoxicity in skeletal muscle
- Glial Cell Line–Derived Neurotrophic Factor Enhances Autophagic Flux in Mouse and Rat Hepatocytes and Protects Against Palmitate Lipotoxicity
- … thyroglobulin (Tg), sodium iodide symporter (NIS), and Thyroperoxidase (TPO) in human primary Thyrocytes: a potential mechanism by which Lipotoxicity …
- Type 1 diabetic cardiomyopathy in the Akita (Ins2WT/C96Y) mouse model is characterized by Lipotoxicity and diastolic dysfunction with preserved systolic function
- Insulin resistance and Lipotoxicity in PCOS: Causes and consequences
- Metformin Reduces Lipotoxicity-Induced Meta-Inflammation in β-Cells through the Activation of GPR40-PLC-IP3 Pathway
- Insulin protects hepatic Lipotoxicity by regulating ER stress through the PI3K/Akt/p53 involved pathway independently of autophagy inhibition
- Early growth response protein-1 mediates Lipotoxicity-associated placental inflammation: role in maternal obesity
- Enhanced oleate uptake and Lipotoxicity associated with laurate
- Nuclear miR-320 mediates diabetes-induced cardiac dysfunction by activating transcription of fatty acid metabolic genes to cause Lipotoxicity in the heart
- Palmitate Lipotoxicity in enteric glial cells: lipid remodeling and mitochondrial ROS are responsible for cyt c release outside mitochondria
- Role of Lipotoxicity and contribution of the renin-angiotensin system in the development of polycystic ovary syndrome
- Angiotensin 1–7 mediates renoprotection against diabetic nephropathy by reducing oxidative stress, inflammation, and Lipotoxicity
- Hepatic amiodarone Lipotoxicity is ameliorated by genetic and pharmacological inhibition of endoplasmatic reticulum stress
- Clerodendron glandulosum. Coleb extract ameliorates high fat diet/fatty acid induced Lipotoxicity in experimental models of non-alcoholic steatohepatitis
- Involvement of sarco/endoplasmic reticulum calcium ATPase-mediated calcium flux in the protective effect of oleic acid against Lipotoxicity in hepatocytes
- β-Cell Lipotoxicity after an overnight intravenous lipid challenge and free fatty acid elevation in African American versus American white overweight/obese adolescents
- GCN5L1 controls renal Lipotoxicity through regulating acetylation of fatty acid oxidation enzymes
- Sirtuin 3 acts as a negative regulator of autophagy dictating hepatocyte susceptibility to Lipotoxicity
- Supplementation of grape seed and skin extract to orlistat therapy prevents high-fat diet-induced murine spleen Lipotoxicity
- Scopoletin intervention in pancreatic endoplasmic reticulum stress induced by Lipotoxicity
- Protective effect of total flavonoid C-glycosides from Abrus mollis extract on lipopolysaccharide-induced Lipotoxicity in mice
- Metformin ameliorates Lipotoxicity-induced mesangial cell apoptosis partly via upregulation of glucagon like peptide-1 receptor (GLP-1R)
- Treatment of cigarette smoke extract and condensate differentially potentiates palmitic acid-induced Lipotoxicity and steatohepatitis in vitro
- Glucagon-like peptide 1 receptor plays an essential role in geniposide attenuating Lipotoxicity-induced β-cell apoptosis
- Induction of stearoyl-CoA 9-desaturase 1 protects human mesenchymal stromal cells against palmitic acid-induced Lipotoxicity and inflammation
- The non-peptidyl low molecular weight radical scavenger IAC protects human pancreatic islets from Lipotoxicity
- Hop and Acacia Phytochemicals Decreased Lipotoxicity in 3T3-L1 Adipocytes, db/db Mice, and Individuals with Metabolic Syndrome
- 1-Methylnicotinamide ameliorates Lipotoxicity-induced oxidative stress and cell death in kidney proximal tubular cells
- An attempt to reverse cardiac Lipotoxicity by aerobic interval training in a high-fat diet-and streptozotocin-induced type 2 diabetes rat model
- Dietary fish oil reverses Lipotoxicity, altered glucose metabolism, and nPKCε translocation in the heart of dyslipemic insulin-resistant rats
- Perilipin 5 fine-tunes lipid oxidation to metabolic demand and protects against Lipotoxicity in skeletal muscle
- Inhibition of the low molecular weight protein tyrosine phosphatase (LMPTP) as a potential therapeutic strategy for hepatic progenitor cells Lipotoxicity
- Glutamine deprivation induces metabolic adaptations associated with beta cell dysfunction and exacerbate Lipotoxicity
- Contribution of free fatty acids to impairment of insulin secretion and action. mechanism of beta-cell Lipotoxicity
- Thrombospondin 1 protects pancreatic β-cells from Lipotoxicity via the PERK–NRF2 pathway
- UCP3 in muscle wasting, a role in modulating Lipotoxicity?
- The role of uncoupling protein 3 in fatty acid metabolism: protection against Lipotoxicity?
- The involvement of PPARs in the causes, consequences and mechanisms for correction of cardiac Lipotoxicity and oxidative stress
- β-Cell Lipotoxicity in response to free fatty acid elevation in prepubertal youth: African American versus Caucasian contrast
- Baicalin protects AML-12 cells from Lipotoxicity via the suppression of ER stress and TXNIP/NLRP3 inflammasome activation
- Lipotoxicity and mitochondrial dysfunction in type 2 diabetes
- Lipotoxicity: impact on oocyte quality and reproductive efficiency in mammals
- Metabolomics analysis of the protective effect of rubusoside on palmitic acid-induced Lipotoxicity in INS-1 cells using UPLC-Q/TOF MS
- … to autophagy-related 7 (Atg7)-induced nod-like receptor 3 (NLRP3)-dependent proinflammatory response and aggravates Lipotoxicity in rat insulinoma cell …
- Global metabolite profiling analysis of Lipotoxicity in HER2/neu-positive breast cancer cells
- Cholesterol accumulation and diabetes in pancreatic β-cell-specific SREBP-2 transgenic mice: a new model for Lipotoxicity
- Gene expression regulated by pioglitazone and exenatide in normal and diabetic rat islets exposed to Lipotoxicity
- Puerarin Suppresses Na+-K+-ATPase–Mediated Systemic Inflammation and CD36 Expression, and Alleviates Cardiac Lipotoxicity In Vitro and In Vivo
- Identification of genes that regulate multiple cellular processes/responses in the context of Lipotoxicity to hepatoma cells
- Does endurance training protect from Lipotoxicity?
- Treatment with didemnin B, an elongation factor 1A inhibitor, improves hepatic Lipotoxicity in obese mice
- Conditional intestinal Lipotoxicity in Apobec-1-/-Mttp-IKO mice: a survival advantage for mammalian intestinal apolipoprotein B mRNA editing
- Effect of fenofibrate and metformin on Lipotoxicity in OLETF rat kidney
- Lipotoxicity-related hematological disorders in obesity
- Exendin-4 ameliorates Lipotoxicity-induced glomerular endothelial cell injury by improving ABC transporter A1-mediated cholesterol efflux in diabetic apoE …
- Chronic palmitic acid-induced Lipotoxicity correlates with defective trafficking of ATP sensitive potassium channels in pancreatic β cells
- … of uncoupling protein-2 up-regulation and triglyceride accumulation in impaired glucose-stimulated insulin secretion in a β-cell Lipotoxicity model overexpressing sterol …
- Lactoferrin attenuates fatty acid-induced Lipotoxicity via Akt signaling in hepatocarcinoma cells
- Relative quantitative comparison between Lipotoxicity and glucotoxicity affecting the PARP-NAD-SIRT1 pathway in hepatocytes
- Dihydroceramide desaturase 1, the gatekeeper of ceramide induced Lipotoxicity
- Fetuin‐A aggravates Lipotoxicity in podocytes via interleukin‐1 signaling
- Glucagon‐like peptide‐1 ameliorates cardiac Lipotoxicity in diabetic cardiomyopathy via the PPAR α pathway
- Exendin-4, a glucagon-like peptide-1 receptor agonist, inhibits cell apoptosis induced by Lipotoxicity in pancreatic β-cell line
- … to mitochondrial reactive oxygen species (ROS)-induced nod-like receptor 3 (NLRP3) dependent proinflammatory response and aggravates Lipotoxicity
- … changes in histone modifications, mRNA levels, and metabolite profiles in clonal INS-1 832/13 β-cells accompany functional adaptations to Lipotoxicity
- Glucotoxicity and Lipotoxicity, two implicated accomplices in the vicious circle of type 2 diabetes
- Hepatocyte mitochondrial DNA released in microparticles and TLR9 activation: A link between Lipotoxicity and inflammation during NASH
- Sphingosine kinase 1 protects hepatocytes from Lipotoxicity via down-regulation of IRE1α protein expression
- n-3 PUFA and Lipotoxicity
- Protective Effects of Broussonetia kazinoki Siebold Fruit Extract against Palmitate-Induced Lipotoxicity in Mesangial Cells
- Troglitazone ameliorates Lipotoxicity in the beta cell line INS-1 expressing PPAR gamma
- The TLR 4‐IRE 1α pathway activation contributes to palmitate‐elicited Lipotoxicity in hepatocytes
- Integrated analysis of chronic Lipotoxicity on muscle metabolism and stress and its reversal by antioxidants
- Stearic acid‐induced cardiac Lipotoxicity is independent of cellular lipid and is mitigated by the fatty acids oleic and capric acid but not by the PPAR agonist …
- Mixed lineage kinase 3 mediates the induction of CXCL10 by a STAT1‐dependent mechanism during hepatocyte Lipotoxicity
- Brain Lipotoxicity of phytanic acid and very long-chain fatty acids. harmful cellular/mitochondrial activities in Refsum disease and X-linked adrenoleukodystrophy
- Role of 3-hydroxy fatty acid-induced hepatic Lipotoxicity in acute fatty liver of pregnancy
- Stevioside counteracts beta-cell Lipotoxicity without affecting acetyl CoA carboxylase
- Secreted protein acidic and rich in cysteine (SPARC) induces Lipotoxicity in neuroblastoma by regulating transport of albumin complexed with fatty acids
- Differential molecular and cellular responses of GLP-1 secreting L-cells and pancreatic alpha cells to glucotoxicity and Lipotoxicity
- Inhibition of galectin-3 ameliorates the consequences of cardiac Lipotoxicity in a rat model of diet-induced obesity
- A new mechanism of Lipotoxicity: calcium channel blockers as a treatment for NASH?
- Analysis of the correlation between Lipotoxicity and pituitary-thyroid axis hormone levels in men and male rats
- Kidney injury molecule-1 is upregulated in renal Lipotoxicity and mediates palmitate-induced tubular cell injury and inflammatory response
- Sphingosine kinase 2 promotes Lipotoxicity in pancreatic β-cells and the progression of diabetes
- Contribution of free fatty acids to impairment of insulin secretion and action: mechanism of beta-cell Lipotoxicity
- Insulin restores UCP3 activity and decreases energy surfeit to alleviate Lipotoxicity in skeletal muscle
- Berberine (BBR) Attenuated Palmitic Acid (PA)-Induced Lipotoxicity in Human HK-2 Cells by Promoting Peroxisome Proliferator-Activated Receptor a (PPAR …
- Acetyl-CoA carboxylase 2 suppression rescues human proximal tubular cells from palmitic acid induced Lipotoxicity via autophagy
- Sortilin 1 modulates hepatic cholesterol Lipotoxicity in mice via functional interaction with liver carboxylesterase 1
- Endogenous GLP-1 as a key self-defense molecule against Lipotoxicity in pancreatic islets
- Elongation factor 1A-1 is a mediator of hepatocyte Lipotoxicity partly through its canonical function in protein synthesis
- Dracorhodin perchlorate protects pancreatic β‐cells against glucotoxicity‐ or Lipotoxicity‐induced dysfunction and apoptosis in vitro and in vivo
- Interleukin-6 deficiency facilitates myocardial dysfunction during high fat diet-induced obesity by promoting Lipotoxicity and inflammation
- Cannabinoid receptor 1 promotes hepatic lipid accumulation and Lipotoxicity through the induction of SREBP-1c expression in zebrafish
- The Effects of Saengkankunbi-tang and Its Composition on Free Fatty Acid-Induced Lipotoxicity in HepG2 Cell
- TAK-875 Mitigates β-Cell Lipotoxicity-Induced Metaflammation Damage through Inhibiting the TLR4-NF-κB Pathway
- Alanine aminotransferase is a marker of Lipotoxicity consequences and hyperandrogenemia in women with polycystic ovary syndrome
- Sulforaphane protects human umbilical vein cells against Lipotoxicity by stimulating autophagy via an AMPK-mediated pathway
- A canola oil-supplemented diet prevents type I diabetes-caused Lipotoxicity and renal dysfunction in a rat model
- Baicalein protects rat insulinoma INS-1 cells from palmitate-induced Lipotoxicity by inducing HO-1
- MicroRNA‑182‑5p contributes to the protective effects of thrombospondin 1 against Lipotoxicity in INS‑1 cells
- The positive effects of olive oil toward Lipotoxicity and obesity
- Mechanistic studies of cholesterol Lipotoxicity pertinent to NASH
- Inhibitory effects of Citrus unshiu pericarpium extracts on palmitate-induced Lipotoxicity in HepG2 cells
- Protective effects of Clec11a in islets against Lipotoxicity via modulation of proliferation and lipid metabolism in mice
- Fasting plasma triglycerides predict the glycaemic response to treatment of type 2 diabetes by gastric electrical stimulation. A novel Lipotoxicity paradigm
- The critical role of Astragalus polysaccharides for the improvement of PPARa-mediated Lipotoxicity in diabetic cardiomyopathy
- Is Lipotoxicity presents in the early stages of an experimental model of autoimmune diabetes? Further studies in the multiple low dose of streptozotocin model
- Interleukin 6 modulates PPARα and PGC-1α and is involved in high-fat diet induced cardiac Lipotoxicity in mouse
- Pathophysiology of prediabetes: Role of Lipotoxicity
- Long chain saturated and unsaturated fatty acids exert opposing effects on viability and function of GLP-1-producing cells: mechanisms of Lipotoxicity
- Development of an in vitro model to study hepatitis C virus effects on hepatocellular Lipotoxicity and lipid metabolism
- The role of the Lipotoxicity in the pathogenesis of type 2 diabetes mellitus and obesity
- Distinct Shift in Beta-Cell Glutaredoxin 5 Expression Is Mediated by Hypoxia and Lipotoxicity Both In Vivo and In Vitro
- Comparative analysis of Lipotoxicity induced by endocrine, pharmacological, and innate immune stimuli in rat basophilic leukemia cells
- Down-regulation of stearoyl-CoA desaturase-1 increases susceptibility to palmitic-acid-induced Lipotoxicity in human trophoblast cells
- Low-dose Exogenous Ouabain alleviates cardiac Lipotoxicity through suppressing expression of CD36
- … of patients with type 2 diabetes mellitus can adapt to extreme short-term increases in circulating lipids and does not display features of acute myocardial Lipotoxicity
- Ameliorative role of palmitoleic acid on palmitate induced Lipotoxicity in the rat cardiomyocytes
- The effect of caveolin-1 (Cav-1) on fatty acid uptake and CD36 localization and Lipotoxicity in vascular smooth muscle (VSM) cells
- Progression from obesity to type 2 diabetes: Lipotoxicity, glucotoxicity, and implications for management.
- Fat accretion in a subpopulation of hepatocytes as a strategy to protect the whole liver against oxidative stress and Lipotoxicity
- Lipotoxicity observed at the early phase of obesity in cats fed on high-fat diet.
- Modulating lipid fate controls Lipotoxicity in palmitate‐treated hepatic cells
- Shielding mitochondria from Lipotoxicity prevents renal injury
- Prevention of palmitic acid‐induced Lipotoxicity by Morinda citrifolia (noni)
- A new pathway to escape Lipotoxicity
- An investigation into the mechanisms of Lipotoxicity in rodent and human-derived β-cell lines
- Therapeutic potential of orlistat-bupropion treatment on high fat diet-induced Lipotoxicity
- Lipid storage droplet protein 5 reduces sodium palmitate‑induced Lipotoxicity in human normal liver cells by regulating lipid metabolism‑related factors
- Oxidative stress and Lipotoxicity of bhang and opium addiction. Effects on adrenal gland secretions
- Predicting and reducing hepatic Lipotoxicity in non-alcoholic fatty liver disease
- Adipocytokines modulate ionic currents–A key to Lipotoxicity potentiated cardiac arrhythmia
- Research of herba artemisiae scoporiae inhibits the hepatic Lipotoxicity
- GLUCOSOTOXICITY AND Lipotoxicity ARE MUTUALLY AGGRAVATING FACTORS IN CONCOMITANCE OF TYPE 2 DIABETES MELLITUS AND OBESITY
- MicroRNA-34a contributes to the protective effects of glucagon-like peptide-1 against Lipotoxicity in INS-1 cells
- The epidemic of type 2 diabetes mellitus: its links to obesity, insulin resistance, and Lipotoxicity
- Reversibility of intrathoracic Lipotoxicity in obesity after bariatric surgery: use of magnetic resonance imaging
- Impairing beta-oxidation contributes to Lipotoxicity in diabetic cardiomyopathy
- Microbiota and Lipotoxicity
- Nuclear miR-320 controls Lipotoxicity
- Adipose tissue expandability, Lipotoxicity and the metabolic syndrome
- Research progresses on Lipotoxicity and islet microvascular endothelial cells injury
- Microarray data and pathway analyses for human microvascular endothelial cells supplemented with low dose vitamin D or niacin during Lipotoxicity
- Impaired secretion of active GLP‐1 in patients with hypertriglyceridaemia: A novel Lipotoxicity paradigm?
- Analysis depending uniform design on the major herbs in qushi huayu compound for anti-hepatic Lipotoxicity
- Hepatocytes-derived microparticles released during Lipotoxicity induce hepatic stellate cells activation and migration: 773
- Prevention of local Lipotoxicity: a new renoprotective mechanism of peroxisome proliferator-activated receptor-α activation in hypertension and obesity?
- Corrigendum to “Low Citrate Synthase Activity Is Associated with Glucose Intolerance and Lipotoxicity”
- New route for the activation of poly (ADP-ribose) polymerase-1: a passage that links poly (ADP-ribose) polymerase-1 to Lipotoxicity?
- Hepatocytes release microparticles during Lipotoxicity that have potent pro-angiogenic effects in vitro and in vivo through Vanin-1-dependent internalization: 116
- Fabrication of size-controlled linoleic acid particles and evaluation of their in-vitro Lipotoxicity
- Maternal and postnatal high-fat diet interaction leads to greater risk of myocardial dysfunction in offspring via obesity-induced Lipotoxicity, IRS-1 serine phosphorylation …
- In vivo studies of Lipotoxicity in reproductive functions of broiler breeder hens
- … signalling from the PKCζ-GLUT4-glucose pathway back to the SIRT1-CD36-fatty acid pathway similar to resveratrol to ameliorate cardiac myocyte Lipotoxicity
- Fatty Acid and Lipotoxicity in Obesity and Diabetes
- Effects of Chinese wild rice on lipid metabolism and Lipotoxicity in rats fed with high fat/cholesterol diet
- Correction: Fenofibrate Improves Renal Lipotoxicity through Activation of AMPK-PGC-1α in db/db Mice
- The efficacy of combined extracts of red yeast rice and fenugreek on attenuating Lipotoxicity in human HepG2 hepatocytes
- Protective effect of Docosahexaenoic acid (DHA) on Lipotoxicity–induced cell death: implication of PI3K/AKT and MAPK pathways
- Metabolites of Blueberry Anthocyanins Suppress Lipotoxicity Induced Endothelial Inflammation
- Dysregulated fatty acid metabolism in pulmonary arterial hypertension is associated with right ventricular steatosis and Lipotoxicity
- From Randle to Lipotoxicity Through Vranic
- PREVENTION OF FREE FATTY ACID INDUCED HEPATIC Lipotoxicity BY CARNITINE THROUGH RESTORATION OF MITOCHONDRIAL DYSFUNCTION: 1551
- O0040 FREE FATTY ACIDS PROMOTE HEPATIC Lipotoxicity BY STIMULATING TNF-ALPHA EXPRESSION VIA A LYSOSOMAL PATHWAY
- Mechanisms of Lipotoxicity in bone
- The RpL13a snoRNA U33 Forms Novel snoRNPs During Lipotoxicity
- p53-mediated acceleration of mitochondrial oxygen consumption promotes Lipotoxicity via SCO2 in diabetic mice
- Effects Associated with High Fat Diet on Insulin Secretion and Biosynthesis in Pancreatic Islet Transplants to Diabetic Rats: No Evidence for” Lipotoxicity“
- Mesenchymal stem cells ameliorate palmitic acid induced Lipotoxicity of human umbilical vein endothelial cells and high‐fat induced obese rats by suppression of …
- The role of C/EBP homologous protein in HIV protease inhibitor-induced hepatic Lipotoxicity
- Lipotoxicity and Diabetes Mellitus
- FP416 SGLT2 inhibitor protected renal proximal tubular cells from apoptosis by reducing intra-renal Lipotoxicity
- Calcium Promotes Oxidative Stress and Metabolic Dysfunction in Lipotoxicity
- Role of UCP-2 Up-regulation and TG accumulation in Impaired Glucose-stimulated Insulin Secretion in a {beta}-Cell Lipotoxicity Model Overexpressing SREBP …
- Lipotoxicity in smooth muscle
- Cumulus cells protect the bovine oocyte against Lipotoxicity by converting saturated into unsaturated fatty acids using stearoyl-CoA-desaturase during in vitro …
- Lipotoxicity in diabetic cardiomyopathy
- Cellular mechanisms that promote or prevent Lipotoxicity
- Effects of cereal dietary fiber on lipid metabolism and Lipotoxicity in mice fed with high fat/cholesterol diet
- EPA prevents palmitate-induced β-cell Lipotoxicity by suppression of SREBP-1c
- High-fat diet causes Lipotoxicity responses in cumulus-oocyte complexes and decreased fertilization rates
- Metabolic Determinants of Hepatic Lipotoxicity
- Interplay between Lipotoxicity and glucotoxicity in the development of diabetic retinopathy
- A new Lipotoxicity pathway in yeast
- Attenuation of palmitic acid-induced Lipotoxicity by chlorogenic acid
- The Role of Protein Kinase R in Lipotoxicity
- Cellular mechanisms by which alcohol promotes HIV protease inhibitor‐induced liver Lipotoxicity
- Erratum to: The p66Shc redox adaptor protein is induced by saturated fatty acids and mediates Lipotoxicity-induced apoptosis in pancreatic beta cells
- Lipotoxicity in Humans: Effects of a Very Low Calorie Diet and Starvation on Myocardial Triglyceride Content and Cardiac Function.
- Vascular Endothelial Growth Factor B-Role in Metabolism, Lipotoxicity and Disease
- Research Article Low Citrate Synthase Activity Is Associated with Glucose Intolerance and Lipotoxicity
- Weapons of mass destruction: Pandemic Lipotoxicity in the US
- Islet brain 1 protects insulin producing cells against Lipotoxicity
- Effects of Niacin and Vitamin D on Endothelial Cell Angiogenic Function and Vascular Regeneration During Lipotoxicity
- Fatty acid-induced Lipotoxicity inhibits choline metabolism independent of ER stress in mouse primary hepatocytes
- Lipotoxicity in Non-parenchymal Liver Cells
- Role of lipid metabolic pathways in the progression of hepatic Lipotoxicity
- Bone lipid deposits: towards bone Lipotoxicity phenomena?
- Demethyleneberberine Attenuates Free Fatty Acid‐And High Fat Diet‐Induced Hepatic Lipotoxicity By Activating AMP‐Activated Protein Kinase
- Lipotoxicity IN OBESITY AND CORONARY ARTERY DISEASE
- Studying protective compounds against Lipotoxicity on insulinoma cell line
- Exploring Differences in Individual Susceptibility to Lipotoxicity and the Underlying Mechanisms in the Mitochondria of Primary Preadipocytes
- Mixed lineage kinase 3 connects hepatocellular Lipotoxicity with macrophage chemotaxis
- Mechanisms underlying Lipotoxicity and glucotoxicity in pancreatic islets
- Lipotoxicity damage of myocardium in obesity
- Myocardial apoptosis in acute diabetes: role of Lipotoxicity and oxidative stress
- Mass spectrometry analysis of the phosphoproteome in an in vitro Lipotoxicity model
- Research Article The Effect of Lipotoxicity on Renal Dysfunction in a Nonobese Rat Model of Metabolic Syndrome: A Urinary Proteomic Approach
- Magnetic resonance imaging and spectroscopy: a noninvasive window into Lipotoxicity
- Lipotoxicity and calpains: exploring the role of calpains for lipid stress in yeast and flies
- Effect of inhibition of the protein tyrosine phosphatase 1B in Lipotoxicity in liver progenitor oval cells
- Aerobic exercise training prevents renal Lipotoxicity associated with insulin resistance in mice
- Effects of niacin in human vascular endothelial cells during Lipotoxicity
- Plin2 Protects Against Palmitate-mediated Lipotoxicity in a Cardiomyoblast Cell Line
- The effect of rice bran extract on cardiovascular Lipotoxicity in rats fed a high-fat diet
- Effects of Cigu Xiaozhi Pills on Lipotoxicity and Oxidative Stress in Rats with Non-alcoholic Steatohepatitis
- Exploring the Possibility of Changes in SIRT1 Activity in Lipotoxicity-mediated β-cell Dysfunction
- Palmitic acid Lipotoxicity is determined by the interaction of JNK with mitochondrial Sab (SH3BP5): 1091
- CAN STEVIA LEAF EXTRACTS PROTECT BETA CELLS AGAINST GLUCO-OR Lipotoxicity?
- Effects of skeletal muscle Lipotoxicity on muscle protein synthesis: implications for athletic and ageing populations
- The Action of Phytochemicals on Lipid Accumulation and Lipotoxicity in HepG2 Cultured Cells
- Role of lipids and Lipotoxicity in diabetic renal disease
- Characterization of Palmitic Acid Induced Lipotoxicity in Schwann Cells
- Lipotoxicity Accounts for Liver Injury due to Etomoxir: Application of Systems Toxicology Modeling of a Patient Population
- HIV and its treatment lead to metabolic disturbances as a result of disrupted cellular respiration and Lipotoxicity
- Conditional Intestinal Lipotoxicity in Apobec-1/Mttp-IKO Mice
- Obesity on increases lipid droplets and Lipotoxicity responses in the periovulatory cumulus-oocyte-complex
- Effect of Lipotoxicity on ER Stress, Autophagy and Apoptosis in Skeletal Muscle and Regulation by Adiponectin
- Lipotoxicity in myocardial infarction and heart failure. Importance of endogenous lipoproteins for cardiac function, structure and arrhythmias.
- Over-expression of HNF4 alpha attenuated Lipotoxicity in non-alcoholic fatty liver disease model
- Prevention of free fatty acids/high fat diet‐induced hepatic Lipotoxicity by 18β glycyrrhetinic acid
- Protective effect of FTO ablation against palmitic acid-induced Lipotoxicity in NASH
- Role of endoplasmic reticulum calcium stores in beta-cell ER stress and Lipotoxicity
- Oleic Acid Protected Pancreatic β‐Cell Against Saturated Fatty Acid Induced Lipotoxicity
- Myristic acid potentiates palmitic acid-induced ceramide generation and Lipotoxicity: 1453
- Lipotoxicity-Induced Extracellular Vesicles Activate Macrophages Through TRAIL Signaling: 1094
- Characterization of PPAR-alpha overexpression in beta-cell Lipotoxicity and its effects on obesity-induced type 2 diabetes
- Limited Fatty Acid Oxidation (FAO) in CPT2 Knockout Myocytes Associates with Insulin Resistance and Cell Stress: possible role of acylcarnitine Lipotoxicity
- … OF RIGHT VENTRICULAR DYSFUNCTION: Bmpr2 Mutation And Western Diet Are Associated With Altered Lipid Transport And Lipotoxicity In The Right Ventricle
- RELEASE OF HEPATOCYTE-DERIVED MICROPARTICLES DURING Lipotoxicity INDUCES ANGIOGENESIS: 1669
- Supplemental Information Cell-to-Cell Heterogeneity in Lipid Droplets Suggests a Mechanism to Reduce Lipotoxicity
- 1 CUMULUS CELLS PROTECT OOCYTES AGAINST POTENTIAL Lipotoxicity FROM ELEVATED FREE FATTY ACID CONCENTRATIONS IN FOLLICULAR FLUID
- Gluco-Lipotoxicity inhibits ceramide transport between endoplasmic reticulum and Golgi apparatus in pancreatic beta cells
- Gastric Mucosal Devitalization Reduces Blood Pressure, Cardiac Lipotoxicity and Endothelial Function in Diet Induced Obese Rats
- Sorcin counteracts Lipotoxicity in palmitate-exposed human beta-cells
- ALA, EPA and DHA differentially Modulate Palmitate-induced Lipotoxicity through Alterations of its Metabolism and Storage in C12C12 Muscle Cells
- Inhibition of excessive mitochondrial fission protects the cardiomyocyte against palmitate‐induced Lipotoxicity
- Dysfunctional Cardiac Lipid Metabolism in Cystathionine-Beta-Synthase Deficient Mice with Obesity-related Cardiac Lipotoxicity
- Research Article Hepatoprotective and Antioxidant Activities of Oil from Baru Almonds (Dipteryx alata Vog.) in a Preclinical Model of Lipotoxicity and …
- Examining Pancreatic Islet Lipotoxicity Using Two-Photon NAD (P) H Imaging
- Peroxisomes in endocrine pancreatic islets, possible protectors against Lipotoxicity?
- Vascular Lipotoxicity: endothelial dysfunction via fatty acid-induced reactive oxygen species overproduction in obese Zucker diabetic fatty rats
- Hypericin Protects Islet β-Cells Against Glucotoxicity and Lipotoxicity in Vitro and in Vivo and Prevents the Onset of Diabetes
- Examining Pancreatic Islet Lipotoxicity by Two-photon NAD (P) H imaging in a Microfluidic Device
- Protection Provided by Phytoestrogens Against Cardiac Lipotoxicity Induced by Palmitic Acid
- Hepatocyte-derived extracellular vesicles released during Lipotoxicity regulate hepatic stellate cell pheno-type via delivery of specific miRNAs and modulation of PPAR …
- Role of translationally controlled tumour protein in palmitate-induced beta-cell Lipotoxicity in type 2 diabetes mellitus
- Ceramide in beta cells apoptosis induced by gluco-Lipotoxicity: possible role of cer flow for the biosynthesis of complex sphingolipids
- Trans 18-carbon monoenoic fatty acid has distinct effects from its isomeric cis fatty acid on Lipotoxicity and gene expression in Saccharomyces cerevisiae
- PPAR/RXR Regulation of Fatty Acid Metabolism and Fatty Acid 𝜔-Hydroxylase (CYP4) Isozymes: Implications for Prevention of Lipotoxicity in Fatty Liver …
- Ventricular Assist Device Implantation Corrects Myocardial Lipotoxicity, Reverses Insulin Resistance and Normalizes Cardiac Metabolism in Advanced Heart Failure
- PPAR-delta Agonist MBX-8025 Abolishes Lipotoxicity andReverses NASH in Diabetic Obese Mice
- Research Article Hop and Acacia Phytochemicals Decreased Lipotoxicity in 3T3-L1 Adipocytes, db/db Mice, and Individuals with Metabolic Syndrome
- Mitochondria, Lipotoxicity and skeletal muscle metabolism: implications for type 2 diabetes mellitus
- Increasing Surface Expression of Pancreatic β cell‐KATP Channels Attenuates Palmitic acid‐induced Lipotoxicity in vivo and in vitro
- Tert-butylhydroquinone (tBHQ) protects hepatocytes against Lipotoxicity via inducing autophagy independently of Nrf2 activation: 1519
- Ventricular Assist Device Implantation Corrects Myocardial Lipotoxicity, Reverses Insulin Resistance and Normalizes Cardiac Metabolism in Advanced Heart Failure
- Limited mitochondrial permeabilization is an early manifestation of palmitate-induced Lipotoxicity in pancreatic ß-cells
- … Screens to Identify Effectors of Three Complex Traits: Neighbour Suppression of Tumour Growth and Proliferation and Protection from Lipotoxicity in β-Cells
- Docosahexaenoic acid (DHA) protects schwann cells against Lipotoxicity: involvement of PI3K and MAPK pathways
- PP008. Lipotoxicity and preeclampsia: A probable correlation (preliminary results)
- Alveolar Lipid Accumulation in GMCSFRβ KO Mice Involves Epithelial Steatosis as well as Macrophage Lipotoxicity and is Not Associated with Altered Surfactant Lipid …
- Mechanistic Investigations of Lipotoxicity in Non-Alcoholic Fatty Liver Disease
- Lipotoxicity‐Evoked Reductions in Nitric Oxide Bioavailability and Exaggerated Oxidant Stress Are Blunted By Blueberry Metabolites in Human Vascular Endothelial …
- … Myocyte Apoptosis and Cardiac Dysfunction via Intervention of Peroxisome Proliferator-activated Receptor Gamma-induced Lipotoxicity and Inflammation in High Fat …
- Type 1 diabetic cardiomyopathy in the Akita (Ins2 WT/C96Y) mouse model is 6 characterized by Lipotoxicity and diastolic dysfunction with preserved 7 systolic function …
- Lipid peroxidation, lipohormesis and Lipotoxicity in diabetes
- Hepatocyte nuclear factor 4-mediated Lipotoxicity provokes mitochondrial damage in peroxisome-deficient pex19 mutants
- Plin2 Attenuates Cardiomyocyte Lipotoxicity
- Cardiac Lipotoxicity Causes Er Stress
- Autophagy: a potential therapeutic target in cardiac Lipotoxicity
- Stearoyl-CoA Desaturase-1 Protects Cells against Lipotoxicity-Mediated Apoptosis in Proximal Tubular Cells.
- 29: MSCs protect hepatocyte from saturated fatty acid induced Lipotoxicity through alleviation of ER stress by enhancing SERCA activity
- Effect of Lipotoxicity on viability and function of pancreatic alpha cells
- Testosterone concentrations in obesity, an outcome of Lipotoxicity?
- Protective effects and mechanisms of MS-275 on Lipotoxicity in C2C12 myocyte
- Non-alcoholic Fatty Liver Disease and Hepatic Lipotoxicity
- Study on the expression of ETFβin diabetic nephropathy and its relationship with Lipotoxicity
- 1-Methylnicotinamide ameliorates Lipotoxicity-induced oxidative stress and cell death in kidney proximal tubular cells.
- The impact of obesity on oocytes: evidence for Lipotoxicity mechanisms
- Mechanism Lipotoxicity in the progression from fatty liver to non-alcoholic steatohepatitis
- Liver X receptor mediated Lipotoxicity represents a treatment option for liver cancer
- Chemical Chaperone 4-Phenyl Butyric Acid (4-PBA) Reduces Hepatocellular Lipid Accumulation and Lipotoxicity Through Induction of Autophagy
- THU0071 Muscle Lipotoxicity on sarcopenia development in a model of collagen-induced arthritis
- Effects of Lipotoxicity and diabetes on hepatocyte function
- Lipotoxicity in adrenoleukodystrophy: Size matters!
- Action of metformin on beta cell Lipotoxicity
- FOXO1 Increases CardiоMyocyte KLF5 Expression, Which Induces Oxidative Stress, Lipotoxicity and Cardiomyopathy in Type 1 Diabetes
- Hepatic Lipotoxicity and Fibrogenesis are attenuated by the hepatotrophic factor ALR
- Role of Lipotoxicity in insulin resistance in subtotally nephrectomized mouse model
- An in vitro model applicable for fatty liver Lipotoxicity pharmacological research
- Protective effects of cyanidin-3-O-glucoside against Lipotoxicity in hypertrophic adipocytes
- Oleic acid reduces palmitic acid-induced Lipotoxicity by AKT activation in HepG2 cells
- A Drosophila Model of Cardiac Lipotoxicity
- 16 The Role of JNK in Lipotoxicity in the Liver
- Cell-to-cell heterogeneity in lipid droplets suggests a mechanism to reduce Lipotoxicity
- Fatty liver and whole-body insulin resistance relate to myocardial Lipotoxicity
- Palmitate‐induced alterations in phospholipid composition promote ER stress and cellular dysfunction in hepatic Lipotoxicity (1001.2)
- Protective Effect of FTO Ablation Against Palmitic Acid-Induced Lipotoxicity in NASH
- Silibinin Protects Hepatocytes from Lipotoxicity by Inducing AMPK Phosphorylation and miRNA130a Expression
- Suppression of Dynamin-Related Protein 1 by Eicosapentaenoic Acid Ameliorates Palmitate-Induced Lipotoxicity in Differenciated H9C2 Myocytes
- Sarcolipin, an Uncoupler of SERCA, Protects against Lipotoxicity and Insulin Resistance
- Establishment of an in vitro model in which HBV promotes hepatocellular steatosis and Lipotoxicity
- Alcohol potentiates HIV protease inhibitor‐induced ER stress and hepatic Lipotoxicity (1001.3)
- 4-Phenylbutyrate reverses endoplasmic reticulum stress and Lipotoxicity in human adipose tissue stem cells
- High-Fat Diet Impairs Beta-Cell Function in Goto-Kakizaki Rats Independently of Lipotoxicity
- Maternal metabolic disorders and fertility: importance of Lipotoxicity on oocyte, sperm and embryo
- Advances in Lipotoxicity and Pancreatic β Cells Apoptosis
- Life congruence with Diabetic epigenetics and Lipotoxicity–
- Fibroblast Growth Factor 21 Limits Lipotoxicity by Promoting Hepatic Fatty Acid Activation in Mice on Methionine and Choline-deficient Diets
- Mechanism of Lipotoxicity-associated apoptosis mediated by mitochondrial dysfunction in pancreatic β-cells
- SIRT3 protects against palmitate-induced neuronal Lipotoxicity
- Liposomal Prednisolone Aggravates Atherosclerosis by Promoting Lipotoxicity in Macrophages
- P 1| Stearoyl-CoA-desaturase activity in cumulus cells protects the oocyte against Lipotoxicity
- Reversal of Intramuscular Lipotoxicity is Mediated by a Novel p62-lipophagy Pathway
- Disturbances in Cardiac Glutathione Augments Cardiac Lipotoxicity in Mice with Diet‐Induced Obesity
- Clinical diagnosis of metabolic syndrome 2. Lipotoxicity as a mechanism of the metabolic syndrome
- SIRT3 enables neuronal β-oxidation and protects against Lipotoxicity
- AKR1C3-mediated adipose androgen generation drives Lipotoxicity in polycystic ovary syndrome
- Changes of Gene Expression in INS-1 cells: The implication of palmitate in Lipotoxicity
- Cardiac Lipotoxicity is greater in Cystathionine‐β‐Synthase Deficient Mice with Diet Induced Obesity
- Effect of leptin on protecting rat islet?-cells against Lipotoxicity induced by free fatty acid
- Beneficial Effects of Probucol for Type 2 Diabetes: Protection of Pancreatic [Beta]-Cells against Oxidative Stress and Lipotoxicity
- SGLT2 inhibitor protects cardiomyocytes against palmitate-induced Lipotoxicity by increasing activation of AMPK and lipid oxidations
- Effect of micronised fenofibrate on Lipotoxicity and insulin sensitivity in spontaneously hypertensive rats treated with high-fat diet
- The Evaluation of Oleic Acid in the Prevention of Lipotoxicity Induced by Palmitic Acid in Rat Cultured Cardiomyocytes
- C-peptide as potential marker for improvement of β cells following glucotoxicity and Lipotoxicity and its status after intensive early insulin therapy
- 18beta‐glycyrrhetinic acid prevents free fatty acid‐induced Lipotoxicity by inhibiting ER stress and oxidative stress
- Small nuclear ribonucleoprotein D3 regulates small nucleolar RNA expression during Lipotoxicity
- Role of metabolic lipases and Lipotoxicity in the development of non-alcoholic steatosis and non-alcoholic steatohepatitis
- Alcohol and HIV Protease Inhibitor‐induced inflammasome activation and hepatic Lipotoxicity
- Alcohol and HIV Protease Inhibitor‐induced inflammasome activation and liver Lipotoxicity
- A Porcine Placental Extract Alleviates Lipotoxicity-Induced NASH by Polarizing M2 Macrophages and Attenuating Stellate Cell Activation in Mice
- Increased Circulating Levels of Total and Very Long-Chain Ceramides as Markers of Abnormal Lipid Metabolism and Lipotoxicity in Patients With Chronic Stable …
- … STRESSED? ENDOPLASMIC RETICULUM, PROTEIN FOLDING, AND OXIDATION IN LUNG DISEASE: Obesity-Induced Lipotoxicity Increases Endoplasmic Reticular …
- 1799-P: Lipotoxicity Impairs Central Regulation of Endogenous Glucose Production (EGP) in Type 2 Diabetes (T2D)
- In the article “Vascular Lipotoxicity: Endothelial Dysfunction via Fatty-Acid-Induced Reactive Oxygen Species Overproduction in Obese Zucker Diabetic Fatty Rats” by …
- Inhibition Of Ceramide Biosynthesis Decreases Cardiomyopathy In Lipoprotein Lipase (LpL) Lipotoxicity
- 1865-P: Dual Chemokine Receptor CCR2/CCR5 Antagonist Cenicriviroc Ameliorates Lipotoxicity-Induced Insulin Resistance and NASH in Mice
- OP4-4: Protective effect of sirt3 on Lipotoxicity-induced β cell dysfunction
- 151. Lipotoxicity MEDIATED ENDOPLASMIC RETICULUM STRESS, MITOCHONDRIAL DYSFUNCTION AND APOPTOSIS CONTRIBUTE IMPAIRED OOCYTE …
- 106 The diabetes influence on the expression of Lipotoxicity associated with preeclampsia: Immune and inflammatory mechanisms
- 2167-P: Gamma-Hydroxybutyrate Prevents Lipotoxicity-Induced ß-Cell Dysfunction
- Angiotensin 1-7 Ameliorates Diabetic Cardiomyopathy in db/db Mice by Reducing Lipotoxicity: A Critical Role for Adipose Triglyceride Lipase
- [170-PO]: Preeclampsia in a reference hospital: Possible association with Lipotoxicity
- 101 Possible markers of Lipotoxicity and anthropometric data in preeclampsia: A study of the mediate postpartum: Immune and inflammatory mechanisms
- (25) Action of phytochemicals on lipid accumulation and Lipotoxicity in hepg2 cells
- 451-P: SGLT2 Inhibitor Protects Cardiomyocytes against Palmitate-Induced Lipotoxicity by Increasing Activation of AMPK and Lipid Oxidations
- Fibroblast Growth Factor 21 Prevents Diabetic Cardiomyopathy by Attenuating Cardiac Lipotoxicity via Erk1/2-dependent Signaling Pathway in Mice
- O-022: Hepatocyte Nuclear Factor 4Alpha Attenuates Lipotoxicity and Hepatic Fibrosis in Nonalcoholic Fatty Liver Disease Model
- Corrigendum to” Disruption of calpain reduces Lipotoxicity-induced cardiac injury by preventing endoplasmic reticulum stress”[Biochim. Biophy. Acta 1862 (11): 2023 …
- Molecular mechanism of Lipotoxicity as an interesting aspect in the development of pathological states—current view of knowledge
- Renal Lipotoxicity: Insights from experimental models
- Lipotoxicity as the leading cause of non-alcoholic steatohepatitis
- Lipid metabolism in sickness and in health: Emerging regulators of Lipotoxicity
- Renal lipid metabolism and Lipotoxicity in diabetes
- Lipotoxicity, mitotoxicity, and drug targets
- Lipotoxicity and diabetic nephropathy: novel mechanistic insights and therapeutic opportunities
- Novel insights and mechanisms of Lipotoxicity-driven insulin resistance
- Understanding Lipotoxicity in NAFLD pathogenesis: is CD36 a key driver?
- Non-alcoholic fatty liver disease and Lipotoxicity
- Molecular mechanisms of Lipotoxicity-induced pancreatic β-cell dysfunction
- How does hepatic lipid accumulation lead to Lipotoxicity in non-alcoholic fatty liver disease?
- The contribution of Lipotoxicity to diabetic kidney disease
- Lipotoxicity and cytokine storm in severe acute pancreatitis and COVID-19
- The vicious cycle of renal Lipotoxicity and mitochondrial dysfunction
- Eicosapentaenoic acid attenuates renal Lipotoxicity by restoring autophagic flux
- Defective mitochondrial fatty acid oxidation and Lipotoxicity in kidney diseases
- Lipotoxicity, glucotoxicity and some strategies to protect vascular smooth muscle cell against proliferative phenotype in metabolic syndrome
- Hepatocyte-specific IL11 cis-signaling drives Lipotoxicity and underlies the transition from NAFLD to NASH
- Bean Leaves Ameliorate Lipotoxicity in Fatty Liver Disease
- Lipotoxicity, neuroinflammation, glial cells and oestrogenic compounds
- Type 2 diabetes and Alzheimer’s disease: the emerging role of cellular Lipotoxicity
- Lipotoxicity disrupts erythrocyte function: a perspective
- The Role of Endoplasmic Reticulum in Lipotoxicity during MASLD Pathogenesis
- Integrating the contributions of mitochondrial oxidative metabolism to Lipotoxicity and inflammation in NAFLD pathogenesis
- Lipotoxicity: a driver of heart failure with preserved ejection fraction?
- SIRT3 promotes lipophagy and chaperon-mediated autophagy to protect hepatocytes against Lipotoxicity
- GCKIII kinases in Lipotoxicity: Roles in NAFLD and beyond
- Lipotoxicity-related sarcopenia: a review
- Autophagy: A Cellular Guardian against Hepatic Lipotoxicity
- Epicardial adipose tissue and cardiac Lipotoxicity: A review
- Impaired fatty acid metabolism perpetuates Lipotoxicity along the transition to chronic kidney injury
- Palmitic acid Lipotoxicity in microglia cells is ameliorated by unsaturated fatty acids
- LXRα activation and Raf inhibition trigger lethal Lipotoxicity in liver cancer
- Lipotoxicity-induced STING1 activation stimulates MTORC1 and restricts hepatic lipophagy
- Targeting de novo lipid synthesis induces Lipotoxicity and impairs DNA damage repair in glioblastoma mouse models
- Evidence showing Lipotoxicity worsens outcomes in covid-19 patients and insights about the underlying mechanisms
- Effects of high glucose and Lipotoxicity on diabetic podocytes
- Long-chain ceramides are cell non-autonomous signals linking Lipotoxicity to endoplasmic reticulum stress in skeletal muscle
- Melatonin protects mouse testes from palmitic acid‐induced Lipotoxicity by attenuating oxidative stress and DNA damage in a SIRT1‐dependent manner
- Targeting ferroptosis alleviates methionine‐choline deficient (MCD)‐diet induced NASH by suppressing liver Lipotoxicity
- The mitochondrial dicarboxylate carrier prevents hepatic Lipotoxicity by inhibiting white adipocyte lipolysis
- Lycopene prevents the progression of Lipotoxicity-induced nonalcoholic steatohepatitis by decreasing oxidative stress in mice
- A comparative proteomic analysis of extracellular vesicles associated with Lipotoxicity
- The crosstalk between cardiac Lipotoxicity and mitochondrial oxidative stress in the cardiac alterations in diet-induced obesity in rats
- FGF21 protects against hepatic Lipotoxicity and macrophage activation to attenuate fibrogenesis in nonalcoholic steatohepatitis
- FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of Lipotoxicity
- Zn induces lipophagy via the deacetylation of beclin1 and alleviates Cu-induced Lipotoxicity at their environmentally relevant concentrations
- Lipotoxicity and β-cell failure in type 2 diabetes: Oxidative stress linked to NADPH oxidase and ER stress
- Adaptation of oxidative phosphorylation machinery compensates for hepatic Lipotoxicity in early stages of MAFLD
- Targeting mitochondrial ROS-mediated ferroptosis by quercetin alleviates high-fat diet-induced hepatic Lipotoxicity
- Assessing fatty acid-induced Lipotoxicity and its therapeutic potential in glioblastoma using stimulated Raman microscopy
- Oleic acid ameliorates palmitic acid induced hepatocellular Lipotoxicity by inhibition of ER stress and pyroptosis
- Large polystyrene microplastics results in hepatic Lipotoxicity in mice
- Increased glycolysis is an early consequence of palmitate Lipotoxicity mediated by redox signaling
- Dehydrozingerone inhibits renal Lipotoxicity in high‐fat diet–induced obese mice
- SQSTM1/p62 activates NFE2L2/NRF2 via ULK1-mediated autophagic KEAP1 degradation and protects mouse liver from Lipotoxicity
- 17β-estradiol ameliorates Lipotoxicity-induced hepatic mitochondrial oxidative stress and insulin resistance
- Lysosomal Ca2+ as a mediator of palmitate-induced Lipotoxicity
- Liraglutide ameliorates Lipotoxicity-induced inflammation through the mTORC1 signalling pathway
- The role of vegan diets in Lipotoxicity-induced beta-cell dysfunction in type-2-diabetes
- Mitochondria-dependent oxidative stress mediates ZnO nanoparticle (ZnO NP)-induced mitophagy and Lipotoxicity in freshwater teleost fish
- FXR-mediated inhibition of autophagy contributes to FA-induced TG accumulation and accordingly reduces FA-induced Lipotoxicity
- Adiponectin receptor agonist ameliorates cardiac Lipotoxicity via enhancing ceramide metabolism in type 2 diabetic mice
- Natural and chemical compounds as protective agents against cardiac Lipotoxicity
- Lipotoxicity reduces DDX58/Rig-1 expression and activity leading to impaired autophagy and cell death
- Stearoyl CoA desaturase is a gatekeeper that protects human beta cells against Lipotoxicity and maintains their identity
- DES1: A key driver of Lipotoxicity in metabolic disease
- Circ-Tulp4 promotes β-cell adaptation to Lipotoxicity by regulating soat1 expression
- Combined transcriptome and proteome profiling of the pancreatic β-cell response to palmitate unveils key pathways of β-cell Lipotoxicity
- The GLP-1R agonist liraglutide limits hepatic Lipotoxicity and inflammatory response in mice fed a methionine-choline deficient diet
- Mesenchymal stromal cells protect hepatocytes from Lipotoxicity through alleviation of endoplasmic reticulum stress by restoring SERCA activity
- Mitochondrial homeostasis mediates Lipotoxicity in the failing myocardium
- Lipotoxicity downstream of α-synuclein imbalance: a relevant pathomechanism in synucleinopathies?
- The impact of EPA and DHA on ceramide Lipotoxicity in the metabolic syndrome
- Polydatin prevents Lipotoxicity-induced dysfunction in pancreatic β-cells by inhibiting endoplasmic reticulum stress and excessive autophagy
- Effects of Lipotoxicity in brain microvascular endothelial cells during Sirt3 deficiency-potential role in comorbid Alzheimer’s disease
- Lipotoxicity dysregulates the immunoproteasome in podocytes and kidneys in type 2 diabetes
- Role of CD36 in palmitic acid Lipotoxicity in neuro-2a neuroblastoma cells
- Rotten to the cortex: ceramide-mediated Lipotoxicity in diabetic kidney disease
- Activation of the AMPK-SIRT1 pathway contributes to protective effects of Salvianolic acid A against Lipotoxicity in hepatocytes and NAFLD in mice
- Lipotoxicity-induced circGlis3 impairs beta cell function and is transmitted by exosomes to promote islet endothelial cell dysfunction
- Prevention of Lipotoxicity in pancreatic islets with gammahydroxybutyrate
- TFEB-mediated lysosomal exocytosis alleviates high-fat diet–induced Lipotoxicity in the kidney
- Rapamycin affects palmitate-induced Lipotoxicity in osteoblasts by modulating apoptosis and autophagy
- Lipid droplets protect human β-cells from Lipotoxicity-induced stress and cell identity changes
- Oleate restores altered autophagic flux to rescue palmitate Lipotoxicity in hypothalamic neurons
- Lipotoxicity-induced mtDNA release promotes diabetic cardiomyopathy by activating the cGAS-STING pathway in obesity-related diabetes
- Ferulic acid alleviates Lipotoxicity-induced hepatocellular death through the SIRT1-regulated autophagy pathway and independently of AMPK and Akt in AML …
- Autophagy activation, Lipotoxicity and lysosomal membrane permeabilization synergize to promote pimozide-and loperamide-induced glioma cell death
- Resveratrol Attenuates High-Fat Diet–Induced Hepatic Lipotoxicity by Upregulating Bmi-1 Expression
- CTRP9 knockout exaggerates Lipotoxicity in cardiac myocytes and high‐fat diet‐induced cardiac hypertrophy through inhibiting the LKB1/AMPK pathway
- CX3CL1/CX3CR1 interaction protects against Lipotoxicity-induced nonalcoholic steatohepatitis by regulating macrophage migration and M1/M2 status
- Honokiol attenuates Lipotoxicity in hepatocytes via activating SIRT3-AMPK mediated lipophagy
- Cimifugin ameliorates Lipotoxicity-induced hepatocyte damage and steatosis through TLR4/p38 MAPK-and SIRT1-involved pathways
- From Obesity-Induced Low-Grade Inflammation to Lipotoxicity and Mitochondrial Dysfunction: Altered Multi-Crosstalk between Adipose Tissue and …
- Squalene Lipotoxicity in a lipid droplet‐less yeast mutant is linked to plasma membrane dysfunction
- The role of Lipotoxicity in kidney disease: From molecular mechanisms to therapeutic prospects
- CDN1163, an activator of sarco/endoplasmic reticulum Ca2+ ATPase, up‐regulates mitochondrial functions and protects against Lipotoxicity in pancreatic β‐cells
- Hyperlipidemia-induced Lipotoxicity and immune activation in rats are prevented by curcumin and rutin
- Enrofloxacin (ENR) exposure induces Lipotoxicity by promoting mitochondrial fragmentation via dephosphorylation of DRP1 at S627 site
- Class IIa HDACs inhibit cell death pathways and protect muscle integrity in response to Lipotoxicity
- Icosabutate exerts beneficial effects upon insulin sensitivity, hepatic inflammation, Lipotoxicity, and fibrosis in mice
- Medium-chain fatty acids suppress Lipotoxicity-induced hepatic fibrosis via the immunomodulating receptor GPR84
- Canagliflozin attenuates Lipotoxicity in cardiomyocytes and protects diabetic mouse hearts by inhibiting the mTOR/HIF-1α pathway
- Mst1 knockdown alleviates cardiac Lipotoxicity and inhibits the development of diabetic cardiomyopathy in db/db mice
- The anti-aging effects of Renshen Guben on thyrotoxicosis mice: improving immunosenescence, hypoproteinemia, Lipotoxicity, and intestinal flora
- Lipotoxicity, nutrient-sensing signals, and autophagy in diabetic nephropathy
- Selenium Ameliorated Oxidized Fish Oil-Induced Lipotoxicity via the Inhibition of Mitochondrial Oxidative Stress, Remodeling of Usp4-Mediated Deubiquitination, and …
- Empagliflozin ameliorates free fatty acid induced-Lipotoxicity in renal proximal tubular cells via the PPARγ/CD36 pathway in obese mice
- Podocyte Lipotoxicity in CKD
- Magnesium isoglycyrrhizinate reduces hepatic Lipotoxicity through regulating metabolic abnormalities
- Endoplasmic-reticulum-stress-induced Lipotoxicity in human kidney epithelial cells
- Depletion of protein kinase STK25 ameliorates renal Lipotoxicity and protects against diabetic kidney disease
- In vitro comparison of various antioxidants and flavonoids from Rooibos as beta cell protectants against Lipotoxicity and oxidative stress-induced cell death
- Whey peptides stimulate differentiation and lipid metabolism in adipocytes and ameliorate Lipotoxicity-induced insulin resistance in muscle cells
- Lipotoxicity-associated inflammation is prevented by guarana (Paullinia cupana) in a model of hyperlipidemia
- Ultrasonic effects on the degradation kinetics, structural characteristics and protective effects on hepatocyte Lipotoxicity induced by palmitic acid of Pueraria …
- Notoginsenoside R1 ameliorates cardiac Lipotoxicity through AMPK signaling pathway
- Interaction between hepatocytes and proximal tubular epithelial cells in hypoxia-induced Lipotoxicity
- Canagliflozin attenuates Lipotoxicity in cardiomyocytes by inhibiting inflammation and ferroptosis through activating AMPK pathway
- Role of proteolytic systems in Lipotoxicity-induced hepatocellular damage
- Alisol B alleviates hepatocyte lipid accumulation and Lipotoxicity via regulating rarα-pparγ-CD36 cascade and attenuates non-alcoholic steatohepatitis in mice
- Sirt3-Sod2-mROS-mediated manganese triggered hepatic mitochondrial dysfunction and Lipotoxicity in a freshwater teleost
- Characterization of regulatory transcriptional mechanisms in hepatocyte Lipotoxicity
- Liraglutide ameliorates Lipotoxicity-induced oxidative stress by activating the NRF2 pathway in HepG2 cells
- Potentiation of Lipotoxicity in Human EndoC‐βH1 β‐Cells by Glucose is Dependent on the Structure of Free Fatty Acids
- Lipidomics reveals carnitine palmitoyltransferase 1C protects cancer cells from Lipotoxicity and senescence
- ARMCX3 mediates susceptibility to hepatic tumorigenesis promoted by dietary Lipotoxicity
- Exercise and metformin intervention prevents Lipotoxicity-induced hepatocyte apoptosis by alleviating oxidative and ER stress and activating the AMPK/Nrf2 …
- Empagliflozin-enhanced antioxidant defense attenuates Lipotoxicity and protects hepatocytes by promoting FoxO3a-and Nrf2-mediated nuclear translocation …
- DGAT1 protects tumor from Lipotoxicity, emerging as a promising metabolic target for cancer therapy
- Exercise inhibits JNK pathway activation and Lipotoxicity via macrophage migration inhibitory factor in nonalcoholic fatty liver disease
- Inhibitory antibodies against PCSK9 reduce surface CD36 and mitigate diet-induced renal Lipotoxicity
- Exercise training reverses Lipotoxicity-induced cardiomyopathy by inhibiting HMGCS2.
- Sphingolipids mediate Lipotoxicity in muscular dystrophies
- Lipotoxicity in a Vicious Cycle of Pancreatic Beta Cell Exhaustion
- Rab7a-mTORC1 signaling-mediated cholesterol trafficking from the lysosome to mitochondria ameliorates hepatic Lipotoxicity induced by aflatoxin B1 exposure
- Zinc attenuates sulfamethoxazole-induced Lipotoxicity by reversing sulfamethoxazole-induced mitochondrial dysfunction and lysosome impairment in a freshwater …
- Lipotoxicity as a Barrier for T Cell-Based Therapies
- Nicotinamide N-methyltransferase upregulation via the mTORC1-ATF4 pathway activation contributes to palmitate-induced Lipotoxicity in hepatocytes
- Cyclic AMP-binding protein Epac1 acts as a metabolic sensor to promote cardiomyocyte Lipotoxicity
- Effect of Lipotoxicity on mitochondrial function and epigenetic programming during bovine in vitro embryo production
- Epigallocatechin gallate alleviates high-fat diet-induced hepatic Lipotoxicity by targeting mitochondrial ROS-mediated ferroptosis
- Resveratrol ameliorates diabetic kidney injury by reducing Lipotoxicity and modulates expression of components of the junctional adhesion molecule-like/sirtuin 1 lipid …
- MnO2 nanoparticles trigger hepatic Lipotoxicity and mitophagy via mtROS-dependent Hsf1Ser326 phosphorylation
- Transcriptomics of natural and synthetic vitamin D in human hepatocyte Lipotoxicity
- (+)-lipoic acid reduces Lipotoxicity and regulates mitochondrial homeostasis and energy balance in an in vitro model of liver steatosis
- Black mulberry (Morus nigra L.) polysaccharide ameliorates palmitate-induced Lipotoxicity in hepatocytes by activating Nrf2 signaling pathway
- Beta cell Lipotoxicity in the development of type 2 diabetes: the need for species-specific understanding
- Sestrin proteins protect against Lipotoxicity-induced oxidative stress in the liver via suppression of C-Jun N-terminal kinases
- Environmentally relevant concentrations of clozapine induced Lipotoxicity and gut microbiota dysbiosis in Chinese rare minnow (Gobiocypris rarus)
- Aqueous extract of pepino leaves ameliorates palmitic acid-induced hepatocellular Lipotoxicity via inhibition of endoplasmic reticulum stress and apoptosis
- Improvement of Lipotoxicity-Induced Islet β Cellular Insulin Secretion Disorder by Osteocalcin
- The Chinese herbal medicine Fufang Zhenzhu Tiaozhi protects against diabetic cardiomyopathy by alleviating cardiac Lipotoxicity-induced oxidative stress …
- Exploiting Lipotoxicity for the treatment of liver cancer
- Aflatoxin B1 exposure triggers hepatic Lipotoxicity via p53 and perilipin 2 interaction-mediated mitochondria-lipid droplet contacts: An in vitro and in vivo assessment
- PERK prevents hepatic Lipotoxicity by activating the p62-ULK1 axis-mediated noncanonical KEAP1-Nrf2 pathway
- GPR43 activation-mediated Lipotoxicity contributes to podocyte injury in diabetic nephropathy by modulating the ERK/EGR1 pathway
- CCDC92 deficiency ameliorates podocyte Lipotoxicity in diabetic kidney disease
- The Role of Triacylglycerol in the Protection of Cells against Lipotoxicity under Drought in Lolium multiflorum/Festucaarundinacea Introgression Forms
- Lipotoxicity-polarised macrophage-derived exosomes regulate mitochondrial fitness through Miro1-mediated mitophagy inhibition and contribute to type 2 …
- Heart-Type Fatty Acid Binding Protein Binds Long-Chain Acylcarnitines and Protects against Lipotoxicity
- Docosahexaenoic acid protection against palmitic acid‐induced Lipotoxicity in NGF‐differentiated PC12 cells involves enhancement of autophagy and inhibition of …
- Artificial lipid droplets: novel effective biomaterials to protect cells against oxidative stress and Lipotoxicity
- Targeting Extracellular RNA Mitigates Hepatic Lipotoxicity and Liver Injury in NASH
- Empagliflozin reduces podocyte Lipotoxicity in experimental Alport syndrome
- Intervention by picroside II on FFAs induced lipid accumulation and Lipotoxicity in HepG2 cells
- Aminoglycoside-induced Lipotoxicity and its reversal in kidney on chip
- Positive allosteric γ‐aminobutyric acid type A receptor modulation prevents Lipotoxicity‐induced injury in hepatocytes in vitro
- Inhibition of TLR4/MAPKs pathway contributes to the protection of salvianolic acid A against Lipotoxicity-induced myocardial damage in cardiomyocytes and …
- Clusterin protects Lipotoxicity-induced apoptosis via upregulation of autophagy in insulin-secreting cells
- Siphonaxanthin, a carotenoid from green algae Codium cylindricum, protects Ob/Ob mice fed on a high-fat diet against Lipotoxicity by ameliorating somatic stresses …
- Loss of SFXN1 mitigates Lipotoxicity and predicts poor outcome in non-viral hepatocellular carcinoma
- Lipotoxicity impairs granulosa cell function through activated endoplasmic reticulum stress pathway
- Lipotoxicity suppresses the synthesis of growth hormone in pituitary somatotrophs via endoplasmic reticulum stress
- When lipid homeostasis runs havoc: Lipotoxicity links lysosomal dysfunction to autophagy
- Therapeutic effects of atorvastatin on doxorubicin‐induced hepatotoxicity in rats via antioxidative damage, anti‐inflammatory, and anti‐Lipotoxicity
- The Role of Gender Differences and Menopause in Obesity-Related Renal Disease, Renal Inflammation and Lipotoxicity
- Inositol-requiring enzyme 1α links palmitate-induced mTOR activation and Lipotoxicity in hepatocytes
- LncRNA-Malat1 is involved in Lipotoxicity-induced ß-cell dysfunction and the therapeutic effect of exendin-4 via Ptbp1
- … Intake of Fish Oil and D-Fagomine Prevents High-Fat High-Sucrose Diet-Induced Prediabetes by Modulating Lipotoxicity and Protein Carbonylation in the …
- Curcumin protects human umbilical vein endothelial cells against high oxidized low density lipoprotein-induced Lipotoxicity and modulates autophagy
- DGAT1 protects against lipid induced-hepatic Lipotoxicity in grass carp (Ctenopharyngodon idellus)
- Allomyrina dichotoma larva extract attenuates free fatty acid-induced Lipotoxicity in pancreatic beta cells
- Melatonin as a Repairing Agent in Cadmium-and Free Fatty Acid-Induced Lipotoxicity
- Salvia hispanica L.(chia) seed improves skeletal muscle Lipotoxicity and insulin sensitivity in rats fed a sucrose-rich diet by modulating intramuscular lipid …
- Palmitate-Induced Cardiac Lipotoxicity Is Relieved by the Redox-Active Motif of SELENOT through Improving Mitochondrial Function and Regulating …
- GPAT4-generated saturated LPAs induce Lipotoxicity through inhibition of autophagy by abnormal formation of omegasomes
- Dietary nano-ZnO is absorbed via endocytosis and ZIP pathways, upregulates lipogenesis, and induces Lipotoxicity in the intestine of yellow catfish
- Knockdown of IL4I1 improved high glucose-evoked insulin resistance in HepG2 cells by alleviating inflammation and Lipotoxicity through AHR activation
- Structural characterization and anti-Lipotoxicity effects of a pectin from okra (Abelmoschus esculentus (L.) Moench)
- Lupin γ-conglutin protects against cell death induced by oxidative stress and Lipotoxicity, but transiently inhibits in vitro insulin secretion by increasing KATP channel …
- Acacetin antagonized Lipotoxicity in pancreatic β-cells via ameliorating oxidative stress and endoplasmic reticulum stress
- N‐glycosylation of CREBH improves lipid metabolism and attenuates Lipotoxicity in NAFLD by modulating PPARα and SCD‐1
- DGKB mediates radioresistance by regulating DGAT1-dependent Lipotoxicity in glioblastoma
- … oxidation via l-carnitine attenuates obesity-related atrial fibrillation and structural remodeling by activating AMPK signaling and alleviating cardiac Lipotoxicity
- Quercetin and Its Derivative Counteract Palmitate-Dependent Lipotoxicity by Inhibiting Oxidative Stress and Inflammation in Cardiomyocytes
- Positive allosteric GABAA receptor modulation counteracts Lipotoxicity-induced gene expression changes in hepatocytes in vitro
- Tranilast protects pancreatic β-cells from palmitic acid-induced Lipotoxicity via FoxO-1 inhibition
- Hepatic Choline Transport Is Inhibited During Fatty Acid–Induced Lipotoxicity and Obesity
- Copper induces liver Lipotoxicity disease by up-regulating Nrf2 expression via the activation of MTF-1 and inhibition of SP1/Fyn pathway
- The mTORC1–G9a–H3K9me2 axis negatively regulates autophagy in fatty acid–induced hepatocellular Lipotoxicity
- … analysis of circRNA expression profile and circRNA-miRNA-mRNA regulatory network between palmitic and stearic acid-induced Lipotoxicity to pancreatic β cells
- The relationship between Lipotoxicity and risk of extrathyroidal extension in papillary thyroid microcarcinoma
- Asymmetric Total Synthesis of Toxicodenane A by Samarium-Iodide-Induced Barbier-Type Cyclization and Its Cell-Protective Effect against Lipotoxicity
- Lipotoxicity in Non-alcoholic Fatty Liver Disease: Mechanisms and Prevention in Experimental Models
- GSK-J4, a specific histone lysine demethylase 6A inhibitor, ameliorates Lipotoxicity to cardiomyocytes via preserving H3K27 methylation and reducing …
- Competing endogenous RNAs in human astrocytes: crosstalk and interacting networks in response to Lipotoxicity
- Mitochondria-Targeted Triphenylphosphonium-Hydroxytyrosol Prevents Lipotoxicity-Induced Endothelial Injury by Enhancing Mitochondrial Function and …
- Natural Product Skatole Ameliorates Lipotoxicity-Induced Multiple Hepatic Damage under Hyperlipidemic Conditions in Hepatocytes
- Sirtuin 3 deficiency aggravates kidney disease in response to high-fat diet through Lipotoxicity-induced mitochondrial damage
- Data-independent acquisition-based quantitative proteomic analysis reveals the protective effect of apigenin on palmitate-induced Lipotoxicity in human aortic …
- Luteolin ameliorates palmitate-induced Lipotoxicity in hepatocytes by mediating endoplasmic reticulum stress and autophagy
- Hydroxycitric acid inhibits kidney stone through crystallization regulation and reduction of hyperoxalate-induced Lipotoxicity
- Activation of LXRs Reduces Oxysterol Lipotoxicity in RPE Cells by Promoting Mitochondrial Function
- Cordycepin protects islet β-cells against glucotoxicity and Lipotoxicity via modulating related proteins of ROS/JNK signaling pathway
- Risks of using mitoquinone during in vitro maturation and its potential protective effects against Lipotoxicity-induced oocyte mitochondrial stress
- Preparation of fatty acid solutions exerts significant impact on experimental outcomes in cell culture models of Lipotoxicity
- Specificities of Lipotoxicity of free fatty acids and cytokine profile in patients with chronic diffuse liver diseases
- Palmitate Lipotoxicity is closely associated with the fatty acid-albumin complexes in BV-2 microglia
- Oleic acid improves hepatic Lipotoxicity injury by alleviating autophagy dysfunction
- FUNDC1 modulates mitochondrial defects and pancreatic β-cell dysfunction under Lipotoxicity
- Obesity-induced alterations to the immunoproteasome: a potential link to intramuscular Lipotoxicity
- The aging features of thyrotoxicosis mice: Malnutrition, immunosenescence and Lipotoxicity
- The role of Lipotoxicity in cardiovascular disease
- 1, 25 (OH) 2D3 ameliorates palmitate-induced Lipotoxicity in human primary osteoblasts leading to improved viability and function
- The spike protein of sars-cov-2 impairs lipid metabolism and increases susceptibility to Lipotoxicity: Implication for a role of nrf2
- Ameliorative effect of Fructus Gardeniae against Lipotoxicity associated hepatocytes injury through activating Nrf2 signaling pathway
- The Coumarin-Derivative Esculetin Protects against Lipotoxicity in Primary Rat Hepatocytes via Attenuating JNK-Mediated Oxidative Stress and Attenuates …
- Salidroside alleviates Lipotoxicity-induced cell death through inhibition of TLR4/MAPKs pathway, and independently of AMPK and autophagy in AML-12 …
- Protopanaxadiol ameliorates palmitate-induced Lipotoxicity and pancreatic β-cell dysfunction in INS-1 cells
- Regulation of Hepatocyte Nuclear Factor 4α Attenuated Lipotoxicity but Increased Bile Acid Toxicity in Non-Alcoholic Fatty Liver Disease
- Oxidative Stress Induced by Lipotoxicity and Renal Hypoxia in Diabetic Kidney Disease and Possible Therapeutic Interventions: Targeting the Lipid …
- Peroxisome deficiency dysregulates fatty acid oxidization and exacerbates Lipotoxicity in β cells
- Targeting endoplasmic reticulum stress—the responder to Lipotoxicity and modulator of non-alcoholic fatty liver diseases
- Sesamin ameliorates Lipotoxicity and lipid accumulation through the activation of the estrogen receptor alpha signaling pathway
- Astaxanthin Ameliorates Worsened Muscle Dysfunction of MDX Mice Fed with a High-Fat Diet through Reducing Lipotoxicity and Regulating Gut Microbiota
- Sodium-glucose cotransporter 2 inhibitors antagonize Lipotoxicity in human myeloid angiogenic cells and ADP-dependent activation in human platelets …
- Apoptotic enteropathy, gluten intolerance, and IBD-like inflammation associated with Lipotoxicity in DGAT1 deficiency–related diarrhea: a case report of a 17-year-old …
- Loss of KDM6B epigenetically confers resistance to Lipotoxicity in nonalcoholic fatty liver disease–related HCC
- Peroxiredomin-4 ameliorates Lipotoxicity-induced oxidative stress and apoptosis in diabetic cardiomyopathy
- Protective effect of empagliflozin against palmitate-induced Lipotoxicity through AMPK in H9c2 cells
- Empagliflozin does not reverse Lipotoxicity-induced impairment in human myeloid angiogenic cell bioenergetics
- Bridelia ferruginea Benth.(Euphorbiaceae) mitigates oxidative imbalance and Lipotoxicity, with concomitant modulation of insulin signaling pathways via GLUT4 …
- Andrographolide Inhibits Lipotoxicity-Induced Activation of the NLRP3 Inflammasome in Bone Marrow-Derived Macrophages
- A novel oral glucagon-like peptide 1 receptor agonist protects against diabetic cardiomyopathy via alleviating cardiac Lipotoxicity induced mitochondria dysfunction
- Progesterone receptor membrane component 1 reduces cardiac steatosis and Lipotoxicity via activation of fatty acid oxidation and mitochondrial respiration
- MKP-5 relieves Lipotoxicity-induced Islet β-cell dysfunction and apoptosis via regulation of autophagy
- Triglyceride-induced cardiac Lipotoxicity is mitigated by Silybum marianum
- Endogenous liver protections against Lipotoxicity and oxidative stress to avoid the progression of non-alcoholic fatty liver to more serious disease
- DPP-4 inhibition with anagliptin reduces Lipotoxicity-induced insulin resistance and steatohepatitis in male mice
- Lipoxin and glycation in SREBP signaling: insight into diabetic cardiomyopathy and associated Lipotoxicity
- Silencing of STE20-type kinase TAOK1 confers protection against hepatocellular Lipotoxicity through metabolic rewiring
- Evogliptin, a DPP-4 inhibitor, prevents diabetic cardiomyopathy by alleviating cardiac Lipotoxicity in db/db mice
- Discoidin domain receptor 1 activation links extracellular matrix to podocyte Lipotoxicity in Alport syndrome
- Exposure to BDE-47 causes female infertility risk and induces oxidative stress and Lipotoxicity-mediated ovarian hormone secretion disruption in mice
- Slow-Release H2S Donor Anethole Dithiolethione Protects Liver From Lipotoxicity by Improving Fatty Acid Metabolism
- Tibolone pre-treatment ameliorates the dysregulation of protein translation and transport generated by palmitic acid-induced Lipotoxicity in human astrocytes …
- PP2Ac knockdown attenuates Lipotoxicity‑induced pancreatic β‑cell dysfunction and apoptosis
- Niacin exacerbates β cell Lipotoxicity in diet-induced obesity mice through upregulation of GPR109A and PPARγ2: Inhibition by incretin drugs
- Shunaoxin pills improve the antihypertensive effect of nifedipine and alleviate its renal Lipotoxicity in spontaneous hypertension rats
- Perilipin 5 reduces oxidative damage associated with Lipotoxicity by activating the PI3K/ERK-mediated Nrf2-ARE signaling pathway in INS-1 pancreatic β-cells
- Persimmon Water Extract Suppresses Hepatic Lipotoxicity by Regulating Lipid Metabolites
- Cyanidin-3-O-glucoside protects intestinal epithelial cells from palmitate-induced Lipotoxicity
- Dual roles of ULK1 (unc-51 like autophagy activating kinase 1) in cytoprotection against Lipotoxicity
- Grape Processing Waste: A Safe Extract to Alleviate High-Fat-Diet-Induced Lipotoxicity and Energy Fueling Alteration in Rat Heart
- Propolis ethanol extract abrogates hyperglycemia, Lipotoxicity, and lowered hepatic poly (ADP-ribose) polymerase protein level in male albino rats
- CXCL5 promotes Lipotoxicity of hepatocytes through upregulating NLRP3/Caspase-1/IL-1β signaling in Kupffer cells and exacerbates nonalcoholic steatohepatitis in …
- Allomyrina dichotoma larva extract attenuates free fatty acid-induced Lipotoxicity in pancreatic beta cells
- Involvement of activation of PLIN5-Sirt1 axis in protective effect of glycycoumarin on hepatic Lipotoxicity
- Transient NADPH oxidase 2-dependent H2O2 production drives early palmitate-induced Lipotoxicity in pancreatic islets
- Bromocriptine protects perilesional spinal cord neurons from Lipotoxicity after spinal cord injury
- Effect of Uncaria tomentosa aqueous extract on the response to palmitate-induced Lipotoxicity in cultured skeletal muscle cells
- FGF21 protects against hepatic Lipotoxicity and macrophage activation to attenuate fibrogenesis in nonalcoholic steatohepatitis
- Aquaporin 9 represents a novel target of chronic liver injury that may antagonize its progression by reducing Lipotoxicity
- VCAM-1: closing the gap between Lipotoxicity and endothelial dysfunction in nonalcoholic steatohepatitis
- Lipotoxicity in human lung alveolar type 2 A549 cells: mechanisms and protection by tannic acid
- Mechanism of action of Lipotoxicity in nonalcoholic steatohepatitis
- BAX/MLKL signaling contributes to Lipotoxicity-induced lysosomal membrane permeabilization in alcohol-associated liver disease
- … inhibition of Sirtuin 3 and cholesterol homeostasis targets acute myeloid leukemia stem cells by perturbing fatty acid β-oxidation and inducing Lipotoxicity
- Loss of Stearoyl-CoA desaturase 1 leads to cardiac dysfunction and Lipotoxicity
- Cardioprotective action of Amaranthus viridis methanolic extract and its isolated compound Kaempferol through mitigating Lipotoxicity, oxidative stress and …
- TLR2 inhibition ameliorates the amplification effect of LPS on lipid accumulation and Lipotoxicity in hepatic cells
- Exendin‑4 inhibits Lipotoxicity‑induced oxidative stress in β‑cells by inhibiting the activation of TLR4/NF‑κB signaling pathway
- Vitamin D Improves the Lipotoxicity of Liver Cells by Adjusting Epigenetic Characteristics of Genes
- Antioxidants rich herbal formula ger-gen-chyn-lian-tang protects Lipotoxicity and ameliorates inflammation signaling through regulation of mitochondrial …
- Combination of canagliflozin and puerarin alleviates the Lipotoxicity to diabetic kidney in mice
- Inhibition of GCN2 Alleviates Cardiomyopathy in Type 2 Diabetic Mice via Attenuating Lipotoxicity and Oxidative Stress
- Wheat germ oil vitamin E cytoprotective effect and its nutrigenomics signature in human hepatocyte Lipotoxicity
- … -Induced Growth Inhibitor (OSGIN1), a Target of X-Box-Binding Protein 1, Protects Palmitic Acid-Induced Vascular Lipotoxicity through Maintaining Autophagy
- Lethal Lipotoxicity for liver cancer therapy
- Nutraceutical modulation of Lipotoxicity and the development of a tool to monitor palmitate induced sub-cellular dysfunction.
- Lipid droplet proteome dynamics and Lipotoxicity
- Identification of a natural PLA2 inhibitor from the marine fungus Aspergillus sp. c1 for MAFLD treatment that suppressed Lipotoxicity by inhibiting the IRE-1α …
- Nifedipine upregulates ATF6-α, caspases-12,-3, and-7 implicating Lipotoxicity-associated renal ER stress
- … and memory: α-synuclein level in children with obesity and children with type 1 diabetes; relation to glucotoxicity, Lipotoxicity and executive functions
- In-vitro evaluation of the cytotoxicity, mitotoxicity and Lipotoxicity potentials of Helichrysum petiolare Hilliard & BL Burtt using HepG2 (C3A) Cell-lines
- Double C-2 like domain beta (DOC2B) induces calcium dependent oxidative stress to promote Lipotoxicity and mitochondrial dysfunction for its tumor suppressive …
- Vitamin D3 Supplementation Alleviates Left Ventricular Dysfunction in a Mouse Model of Diet-Induced Type 2 Diabetes: Potential Involvement of Cardiac Lipotoxicity …
- Multi-tissue Lipotoxicity caused by high-fat diet feeding is attenuated by the supplementation of Korean red ginseng in mice
- ATF4-mediated CD36 upregulation contributes to palmitate-induced Lipotoxicity in hepatocytes
- Novel FoxO1 inhibitor, JY-2, ameliorates palmitic acid-induced Lipotoxicity and gluconeogenesis in a murine model
- Necrostatin-1S mitigates type-2 diabetes-associated cognitive decrement and Lipotoxicity-induced neuro-microglia changes through p-RIPK-RIPK3-p-MLKL axis
- Stearoyl-CoA desaturase 1 deficiency exacerbates palmitate-induced Lipotoxicity by the formation of small lipid droplets in pancreatic β-cells
- Perilipin 2 Protects against Lipotoxicity-Induced Islet Fibrosis by Inducing Islet Stellate Cell Activation Phenotype Changes
- Comparative effects of nanoemulsions loaded with duck oil and lard oil on palmitate‐induced Lipotoxicity
- Recombinant Human Growth Hormone Inhibits Lipotoxicity, Oxidative Stress, and Apoptosis in a Mouse Model of Diabetic Cardiomyopathy
- Lipotoxicity, mitotoxicity, and drug targets
- Paraoxonase 1 Ameliorates Renal Lipotoxicity by Activating Lipophagy and Inhibiting Pyroptosis
- Tripterine Serves a Dual Role in Palmitate-Induced Pancreatic Beta-Cell Lipotoxicity
- IRS-2/Akt/GSK-3β/Nrf2 Pathway Contributes to the Protective Effects of Chikusetsu Saponin IVa against Lipotoxicity
- … Baobab), Cucumeropsis mannii (Melon), and Abelmoschus esculentus (Okro) supplemented diets against cadmium-induced Lipotoxicity, bone demineralization, and …
- Sphingosine-1 phosphate lyase regulates sensitivity of pancreatic beta-cells to Lipotoxicity
- Starvation resistant cavefish reveal conserved mechanisms of starvation-induced hepatic Lipotoxicity
- Cuminum cyminum prevents Lipotoxicity and apoptosis but Cuminaldehyde fails to do so: A study on mouse macrophage (RAW 264.7) cells
- Class IIa HDACs inhibit cell death pathways and protect muscle integrity in response to Lipotoxicity
- Insulin Resistance and Lipotoxicity in PCOS: Causes and Consequences
- Flower Infusions From Cornus mas and Cornus kousa Inhibit Aldose Reductase Enzyme, Without Any Effects on Lipotoxicity
- Blocking glucose to reduce drug-induced Lipotoxicity
- DGAT1 is a lipid metabolism oncoprotein that enables cancer cells to accumulate fatty acid while avoiding Lipotoxicity
- Mechanism of GLP-1 Receptor Agonists-Mediated Attenuation of Palmitic Acid-Induced Lipotoxicity in L6 Myoblasts
- Role of Lipotoxicity in the development and progression of nonalcoholic fatty liver disease
- 1‐Deoxyceramides–Key players in Lipotoxicity and progression to type 2 diabetes?
- Sodium butyrate attenuates aortic Lipotoxicity and impaired nitric oxide synthesis in female Wistar rats exposed to high-fructose drink
- Simultaneous Inhibition of SIRT3 and Cholesterol Homeostasis Targets AML Stem Cells By Perturbing Fatty Acid β-Oxidation and Inducing Lipotoxicity
- Lipotoxicity in the pathogenesis of chronic kidney disease complications
- Multicomponent Ayurveda formulation Lodhrasavam ameliorates steatosis and Lipotoxicity in HepG2 cell model of NAFLD
- Different Phenolic Extracts of Oil Palm Fruits and Caffeic Acid Prevent Palmitic Acid-Induced Lipotoxicity in HepG2 Cells via Improving Mitochondrial Function
- Downregulation of CYP7B1 caused by Lipotoxicity associates with the progression of non-alcoholic steatohepatitis
- Empagliflozin reduces renal Lipotoxicity in experimental Alport syndrome
- Persistent Inflammatory Lipotoxicity Impedes Pancreatic β-cell Function in Diet-Induced Obese Mice Despite Correction of Glucotoxicity
- Beta-Cell Golgi Stress Response to Lipotoxicity and GlucoLipotoxicity: A Preliminary Study of a Potential Mechanism of Beta-Cell Failure in Posttransplant Diabetes …
- The Contribution of Lipotoxicity to Diabetic Kidney Disease. Cells 2022, 11, 3236
- Autocrine IL11 cis-signaling in hepatocytes is an initiating nexus between Lipotoxicity and non-alcoholic steatohepatitis
- Cardiomyocyte-specific ACSL1 Deficiency Prevents Cardiac Lipotoxicity and Alleviates Heart Dysfunction in the ob/ob Model of Obesity
- # 5790 IMPAIRED FATTY ACID METABOLISM PERPETUATES Lipotoxicity ALONG THE TRANSITION TO CHRONIC KIDNEY INJURY
- Mechanisms of Lipotoxicity by Palmitate in ß-cells
- Spatiotemporal correlation spectroscopy reveals a protective effect of peptide-based glp-1 receptor agonism against Lipotoxicity on insulin granule dynamics in primary …
- Increased oxidative stress and mitochondrial impairments associated with increased expression of TNF‐α and caspase‐3 in palmitic acid‐induced Lipotoxicity in …
- Targets for rescue from fatty acid-induced Lipotoxicity in pancreatic beta cells
- FALCON Systematically Interrogates FFA Biology and Identifies New Mediators of Lipotoxicity
- … of synthesis, transport and accumulation of lipids in Lipid droplets by Acetyl-CoA carboxylase and Caveolins. How cells accumulate lipids but reduce Lipotoxicity
- FALCON systematically interrogates FFA biology and identifies new mediators of Lipotoxicity
- Aldehyde dehydrogenase 2 protects cardiomyocytes against Lipotoxicity via the AKT/glycogen synthase kinase 3 beta pathways
- Mechanistic Investigations on the Implications of mTORC1 and ER Stress Crosstalk in Hepatic Lipotoxicity
- Effects of high glucose and Lipotoxicity on diabetic podocytes. Nutrients. 2021; 13: 241
- … Simulation of a Genome-Scale metabolic Model Reveal Controlling Biological Switches in Human Astrocytes Under Palmitic Acid-Induced Lipotoxicity
- CD36-mediated podocyte Lipotoxicity promotes foot process effacement
- Factors to Consider When Determining Whether Lipotoxicity Solely Causes B-Cell Decompensation in KPT2D
- Investigation of novel target proteins for preventing hepatic Lipotoxicity
- Multi-Omic Epigenetic-Based Model Reveals Key Molecular Mechanisms Associated with Palmitic Acid Lipotoxicity in Human Astrocyte
- Nur77 Increases Glucose Transport in Mouse Skeletal Muscle Cells by Activating P38MAPK Under Lipotoxicity
- Real Ambient Particulate Matter-Induced Myocardial Hypertrophy and Myocardial Lipotoxicity: Roles of PDGFRβ Methylation
- Ferulic acid protects palmitic acid-induced Lipotoxicity in hepatocytes via inhibiting p38 MAPK
- # 3976 THE ROLE OF GENDER DIFFERENCES AND MENOPAUSE IN OBESITY-RELATED RENAL DISEASE, RENAL INFLAMMATION AND Lipotoxicity
- Hydrogen sulfide (H₂S) attenuates Lipotoxicity and cardiac cell senescence by regulating protein acetylation
- Regulated in Development and DNA Damage Response 1 Protects Hepatocytes Against Palmitate-induced Lipotoxicity
- The immunosenescence and Lipotoxicity in thyrotoxicosis mice
- Canagliflozin Attenuates Lipotoxicity in Cardiomyocytes and Protects Diabetic Mouse Hearts by Targeting the mTOR/HIF-1α Pathway
- 1779-P: Lipotoxicity-Induced Beta-Cell Small Extracellular Vesicles Promote Beta-Cell Functional Failure through Activation of the TGFß/Smad3 Pathway
- Lipotoxicity, ER Stress, and Cardiovascular Disease: Current Understanding and Future Directions.
- POS-405 THE MECHANISM OF EXOSOMAL MIR-24 FROM TUBULAREPITHELIAL CELLS ACTIVATES Lipotoxicity-INDUCED INFLAMMATION AND PROMOTES …
- Lipotoxicity and induced suppression of fungi associated with decay of melon seeds in Nigeria
- Lipotoxicity, insulin resistance, and iron metabolism in muscle
- Supplementary materials CCDC92 deficiency ameliorates podocyte Lipotoxicity in diabetic kidney disease
- Lipotoxicity-induced metabolic inflammation: potential role of ceramides in glial cells interaction and inflammatory-damage propagation
- FC 084 Lipotoxicity MEDIATED BY GPR43 ACTIVATION CONTRIBUTES TO PODOCYTE INJURY IN DIABETIC NEPHROPATHY THROUGH MODULATING ERK …
- Salvia hispanica L.(chia) seed improves skeletal muscle Lipotoxicity and insulin sensitivity in rats fed a sucrose-rich diet by modulating intramuscular lipid metabolism
- The Downregulation of Scgn Induced by Lipotoxicity Promotes Nlrp3-Mediated Β-Cell Pyroptosis
- Lipotoxicity-induced kidney injury: mechanisms and the prospect of stem cell therapy and gene silencing
- Fructus Gardeniae Attenuates Hepatic Lipotoxicity Induced by Palmitic Acid Via Activating Nrf2 Signalingauthor
- Abstract P3197: Sarm1 Deficiency Protects Mice Against Diabetic Cardiomyopathy: Potential Mechanisms Via Ameliorating Lipotoxicity
- P0974 ADIPORON AMELIORATES DIABETIC CARDIOMYOPATHY IN DBDB MICE THROUGH IMPROVING CERAMIDE-DEPENDENT Lipotoxicity
- Rapid Accumulation of Triacylglycerol in the Liver is a Component of the Acute Exercise Response and May Serve a Protective Role Against Lipotoxicity
- Discovery of Lipotoxicity-sensitive transcription factors in non-alcoholic steatohepatitis
- Loss of PPARα function promotes epigenetic dysregulation of lipid homeostasis driving ferroptosis and pyroptosis Lipotoxicity in Metabolic Dysfunction Associated …
- The effect of SERCA2 activation on liver metabolism during acute Lipotoxicity in vivo
- Corrigendum to” Polyacetylene glycoside attenuates ischemic kidney injury by co-inhibiting inflammation, mitochondria dysfunction and Lipotoxicity“[Life Sci. 204 …
- Molecular Mechanisms of Palmitate Lipotoxicity and Unsaturated Fatty Acid Lipoprotection in Neuronal and Microglial Cells
- Synthesis of Toxicodenane A–A Sesquiterpenoid that Protects Cells from Lipotoxicity
- 1361-P: Patients with Severe Nonalcoholic Steatohepatitis (NASH) Have Profound Insulin Resistance and Lipotoxicity
- 287-LB: Thiazolidinedione Ameliorates Lipotoxicity-Induced Pancreatic ß-Cell Ferroptosis Partly via ACSL4
- Protective effects of omega-3 fatty acids against skeletal muscle cell Lipotoxicity
- 70 Trolox during in vitro maturation of bovine oocytes protects developing embryos from palmitic acid-induced Lipotoxicity
- The Role of Ring Finger Protein 213 in Fatty Acid-induced Lipotoxicity
- Analysis of Neutral Lipid Accumulation and Lipotoxicity in Non-hepatocyte Liver Cells Under Free Fatty-acid Treatment
- Lipotoxicity induced pancreatic beta cell damage is associated with GPR119/MST1/FoxO1 Pathway
- 1609-P: Neutral Sphingomyelinase Inhibition Limits Hepatic-Lipotoxicity and Inflammation in a Cell Model of Steatosis
- Co-culture of Hepatocytes and Proximal Tubular Epithelial Cells Modulates Hypoxia-induced Lipotoxicity
- 838-P: Lipotoxicity-Induced Liver Cell Injury Is Prevented by a Novel Positive Allosteric Modulator of the GABAA Receptor
- 401-P: Effects of Teneligliptin on Lipotoxicity in High-Fat Diet–Induced Diabetic Kidney Disease Model
- Polysiphonia japonica-derived 5-Bromoprotocatechualdehyde protects Ins-1 pancreatic β-cells against palmitate-induced Lipotoxicity
- Identification and characterisation of the eukaryotic Lipotoxicity interaction network (LIN) and modifiers of diacylglycerol-acyltransferase (DGAT)-mediated diseases
- over-activated p21 protein activated kinase-3 (pak3) leads to myocardial Lipotoxicity and cardiac dysfunction in diet-induced metabolic stress
- … RESULTING FROM TOTUM-854 ABSORPTION IN HUMANS PROTECTS PRIMARY HUMAN ENDOTHELIAL CELLS AGAINST Lipotoxicity: LESSONS FROM AN …
- 2087-P: Functional Genomics of Human Islet Gluco/Lipotoxicity and Type 2 Diabetes
