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DNA METHYLATION & AGING

May 10, 2022

REPAIRING DNA DOUBLE STRAND BREAKS

May 10, 2022

μ-Opposing actions of the κ–opiod Receptor
Structure of the human κ–opiod Receptor in complex with JDTic
The dynorphin/κ–opiod Receptor system and its role in psychiatric disorders
Development of κ opiod Receptor antagonists
Dynorphin is a specific endogenous ligand of the κ opiod Receptor
Molecular cloning and tissue distribution of a putative member of the rat opiod Receptor gene family that is not a μ, δ or κ opiod Receptor type
Molecular cloning of a rat κ opiod Receptor reveals sequence similarities to the μ and δ opiod Receptors
Quantitative autoradiographic mapping of μ-, δ-and κ–opiod Receptors in knockout mice lacking the μ-opiod Receptor gene
κ–opiod Receptor/dynorphin system: genetic and pharmacotherapeutic implications for addiction
Molecular cloning and expression of a rat κ opiod Receptor
Cloning of a human κ opiod Receptor from the brain
Pharmacological properties of JDTic: A novel κ–opiod Receptor antagonist
κ opiod Receptor antagonism and prodynorphin gene disruption block stress-induced behavioral responses
μ-and κ–opiod Receptor-meiated opiod effects on social play in juvenile rats
Antipruritic activity of the κ–opiod Receptor agonist, TRK-820
Effects of κ–opiod Receptor ligands on intracranial self-stimulation in rats
CI‐977, a novel and selective agonist for the κ‐opiod Receptor
Depressive-like effects of the κ–opiod Receptor agonist salvinorin A on behavior and neurochemistry in rats
Cellular mechanism for anti-analgesic action of agonists of the κ–opiod Receptor
GEC1 interacts with the κ opiod Receptor and enhances expression of the Receptor
Modulation of the behavioral and neurochemical effects of psychostimulants by κ‐opiod Receptor systems
The role of κ–opiod Receptor activation in mediating antinociception and addiction
5′-Guanidinonaltrindole, a highly selective and potent κ–opiod Receptor antagonist
The role of the dynorphin/κ opiod Receptor system in anxiety
Structure and chromosomal mapping of genes for the mouse κ–opiod Receptor and an opiod Receptor homologue (MOR-C)
Asymmetric synthesis of salvinorin A, a potent κ opiod Receptor agonist
Formation of μ-/κ–opiod Receptor heterodimer is sex-dependent and mediates female-specific opiod analgesia
The intrinsic antinociceptive effects of oxycodone appear to be κ–opiod Receptor mediated
Neuropathic pain activates the endogenous κ opiod system in mouse spinal cord and induces opiod Receptor tolerance
Isolation of a human κ opiod Receptor cDNA from placenta
Antidepressant-like effects of κ–opiod Receptor antagonists in the forced swim test in rats
Research and development of κ opiod Receptor agonists and δ opiod Receptor agonists
Anxiolytic-like effects of κ–opiod Receptor antagonists in models of unlearned and learned fear in rats
Discovery of aminobenzyloxyarylamides as κ opiod Receptor selective antagonists: application to preclinical development of a κ opiod Receptor antagonist Receptor …
Distinct mechanisms for activation of the opiod Receptor-like 1 and κ–opiod Receptors by nociceptin and dynorphin A
Localization of the κ opiod Receptor in lipid rafts
Salvinorin A: a novel and highly selective κ–opiod Receptor agonist
Big dynorphin as a putative endogenous ligand for the κ‐opiod Receptor
Primary astroglial cultures derived from several rat brain regions differentially express μ, δ and κ opiod Receptor mRNA
Quantitative autoradiography of μ-, δ-and κ1 opiod Receptors in κ–opiod Receptor knockout mice
Studies toward the pharmacophore of salvinorin A, a potent κ opiod Receptor agonist
U50, 488, a κ opiod Receptor agonist, attenuates cocaine-induced increases in extracellular dopamine in the nucleus accumbens of rats
Long term κ–opiod Receptor blockade following nor-binaltorphimine
Identification of novel functionally selective κ–opiod Receptor scaffolds
2-Methoxymethyl-salvinorin B is a potent κ opiod Receptor agonist with longer lasting action in vivo than salvinorin A
Systemic κ‐opiod Receptor antagonism by nor‐binaltorphimine reduces dependence‐induced excessive alcohol self‐administration in rats
Synthesis and κ–opiod Receptor activity of furan-substituted salvinorin A analogues
Salvinorin A, an active component of the hallucinogenic sage Salvia divinorum is a highly efficacious κ–opiod Receptor agonist: structural and functional …
Endogenous κ–opiod Receptor systems regulate mesoaccumbal dopamine dynamics and vulnerability to cocaine
The selective κ–opiod Receptor agonist U50, 488H attenuates voluntary ethanol intake in the rat
Novel opiod cyclic tetrapeptides: Trp isomers of CJ‐15,208 exhibit distinct opiod Receptor agonism and short‐acting κ opiod Receptor antagonism
μ-, δ-and κ–opiod Receptor populations are differentially altered in distinct areas of postmortem brains of Alzheimer’s disease patients
Distribution of κ opiod Receptor mRNA in adult mouse brain: an in situ hybridization histochemistry study
Antinociceptive and hypothermic effects of salvinorin A are abolished in a novel strain of κ–opiod Receptor-1 knockout mice
Potent antinociceptive effects of TRK-820, a novel κ–opiod Receptor agonist
Decreased oral self‐administration of alcohol in κ‐opiod Receptor knock‐out mice
κ–opiod Receptor activation modifies dopamine uptake in the nucleus accumbens and opposes the effects of cocaine
The effects of spiradoline (U‐62066E), a κ‐opiod Receptor agonist, on neuroendocrine function in man
Chemotype-selective modes of action of κ–opiod Receptor agonists
The G protein–biased κ–opiod Receptor agonist RB-64 is analgesic with a unique spectrum of activities in vivo
The expression of δ-and κ–opiod Receptor is enhanced during intestinal inflammation in mice
Characterization of mechanical withdrawal responses and effects of μ-, δ-and κ–opiod agonists in normal and μ-opiod Receptor knockout mice
Molecular interaction between butorphanol and κ–opiod Receptor
κ–opiod Receptor is colocalized in GnRH and KNDy cells in the female ovine and rat brain
Antidepressant-like effects of κ–opiod Receptor antagonists in Wistar Kyoto rats
Exploration of the SAR connection between morphinan-and arylacetamide-based κ opiod Receptor (κOR) agonists using the strategy of bridging
Hallucinatory and rewarding effect of salvinorin A in zebrafish: κ–opiod and CB1-cannabinoid Receptor involvement
Neuroprotective actions of GR89696, a highly potent and selective κ‐opiod Receptor agonist
Buprenorphine is a potent κ–opiod Receptor antagonist in pigeons and mice
Functional interaction among opiod Receptor types: up-regulation of μ-and δ-opiod Receptor functions after repeated stimulation of κ–opiod Receptors
Analgesia from a peripherally active κ–opiod Receptor agonist in patients with chronic pancreatitis
Strategies for developing κ opiod Receptor agonists for the treatment of pain with fewer side effects
Agonist‐induced phosphorylation of the κ‐opiod Receptor
Sensitization to the behavioral effects of cocaine: modulation by dynorphin and κ–opiod Receptor agonists
Isolation of a novel cDNA encoding a putative membrane Receptor with high homology to the cloned μ, δ, and κ opiod Receptors
Sex-related differences in mechanical nociception and antinociception produced by μ-and κ–opiod Receptor agonists in rats
Bi-directional heterologous desensitization between the major HIV-1 co-Receptor CXCR4 and the κ–opiod Receptor
Disruption of the κ–opiod Receptor gene in mice enhances sensitivity to chemical visceral pain, impairs pharmacological actions of the selective κ-agonist U-50,488 H …
Toward a structure-based model of salvinorin A recognition of the κ–opiod Receptor
Regional, developmental, and cell cycle‐dependent differences in μ, δ, and κ‐opiod Receptor expression among cultured mouse astrocytes
Synthesis and evaluation of 11C-LY2795050 as a κ–opiod Receptor antagonist radiotracer for PET imaging
Gz coupling to the rat κ–opiod Receptor
Noribogaine is a G-protein biased κ–opiod Receptor agonist
Involvement of the κ–opiod Receptor in the anxiogenic-like effect of CP 55,940 in male rats
Detection of opiod Receptor mRNA by RT-PCR reveals alternative splicing for the δ-and κ–opiod Receptors
Autoradiography of [3H] U-69593 binding sites in rat brain: evidence for κ opiod Receptor subtypes
LPK-26, a novel κ–opiod Receptor agonist with potent antinociceptive effects and low dependence potential
Hippocampal dynorphin B injections impair spatial learning in rats: a κ–opiod Receptor-mediated effect
PD117302: a selective agonist for the κ‐opiod Receptor
Long-acting κ opiod antagonists disrupt Receptor signaling and produce noncompetitive effects by activating c-Jun N-terminal kinase
Double in situ hybridization study on coexistence of μ-, δ-and κ–opiod Receptor mRNAs with preprotachykinin A mRNA in the rat dorsal root ganglia
Norbinaltorphimine, a selective κ–opiod Receptor antagonist, induces an itch-associated response in mice
Enhanced κ–opiod Receptor-mediated analgesia by antisense targeting the σ1 Receptor
Differential agonist regulation of the human κ‐opiod Receptor
δ-, but not μ-and κ-, opiod Receptor activation protects neocortical neurons from glutamate-induced excitotoxic injury
κ–opiod Receptor activation modulates Ca2+ currents and secretion in isolated neuroendocrine nerve terminals
The μ‐opiod Receptor agonist morphine, but not agonists at δ‐or κ‐opiod Receptors, induces peripheral antinociception mediated by cannabinoid Receptors
… -based design, synthesis, and biochemical and pharmacological characterization of novel salvinorin A analogues as active state probes of the κ–opiod Receptor
Mechanisms of agonist-induced down-regulation of the human κ–opiod Receptor: internalization is required for down-regulation
Dynorphin peptides differentially regulate the human κ opiod Receptor
Functional effects of systemically administered agonists and antagonists of μ, δ, and κ opiod Receptor subtypes on body temperature in mice
Murine chromosomal location of the μ and κ opiod Receptor genes
Duration of action of a broad range of selective κ–opiod Receptor antagonists is positively correlated with c-Jun N-terminal kinase-1 activation
Receptor‐selective changes in µ‐, δ‐and κ‐opiod Receptors after chronic naltrexone treatment in mice
Synthesis of CJ-15,208, a novel κ–opiod Receptor antagonist
Synthesis and pharmacological evaluation of 5-pyrrolidinylquinoxalines as a novel class of peripherally restricted κ–opiod Receptor agonists
Chronic muscle pain induced by repeated acid injection is reversed by spinally administered μ-and δ-, but not κ-, opiod Receptor agonists
κ opiod Receptor ligands regulate angiogenesis in development and in tumours
Phosphorylation of a carboxyl-terminal serine within the κ–opiod Receptor produces desensitization and internalization
Association of in vivo κ–opiod Receptor availability and the transdiagnostic dimensional expression of trauma-related psychopathology
Autoradiographic mapping of the opiod Receptor-like 1 (ORL1) Receptor in the brains of μ-, δ-or κ–opiod Receptor knockout mice
Transformation of a κ–opiod Receptor Antagonist to a κ-Agonist by Transfer of a Guanidinium Group from the 5 ‘-to 6 ‘-Position of Naltrindole
Modulation of anxiety-related behaviors by μ-and κ–opiod Receptor agonists depends on the social status of mice
U50, 488H-induced internalization of the human κ opiod Receptor involves a β-arrestin-and dynamin-dependent mechanism: κ Receptor internalization is not …
Repeated exposure to the κ–opiod Receptor agonist salvinorin A modulates extracellular signal-regulated kinase and reward sensitivity
Mechanism of diuretic action of U-62,066 E, a κ opiod Receptor agonist
Anxiety and ethanol consumption in victorious and defeated mice; effect of κ–opiod Receptor activation
The atomistic level structure for the activated human κ–opiod Receptor bound to the full Gi protein and the MP1104 agonist
DAMGO, a μ‐opiod Receptor selective ligand, distinguishes between μ‐and κ‐opiod Receptors at a different region from that for the distinction between μ‐and δ …
Properties of a κ–opiod Receptor expressed in CHO cells: interaction with multiple G-proteins is not specific for any individual Gα subunit and is similar to that of other …
Abuse potential and pharmacodynamic characteristics of oral and intranasal eluxadoline, a mixed μ-and κ–opiod Receptor agonist and δ-opiod Receptor antagonist
Suppression of the GnRH pulse generator by neurokinin B involves a κ–opiod Receptor-dependent mechanism
Agonist-promoted Lys63-linked polyubiquitination of the human κ–opiod Receptor is involved in Receptor down-regulation
Suppression of morphine withdrawal by electroacupuncture in rats: dynorphin and κ–opiod Receptor implicated
Stress-induced activation of the dynorphin/κ–opiod Receptor system in the amygdala potentiates nicotine conditioned place preference
6′-Guanidinonaltrindole (6′-GNTI) is a G protein-biased κ–opiod Receptor agonist that inhibits arrestin recruitment
Pharmacology and anti‐addiction effects of the novel κ opiod Receptor agonist M esyl S al B, a potent and long‐acting analogue of salvinorin A
Essential structure of the κ opiod Receptor agonist nalfurafine for binding to the κ Receptor
Pharmacological properties of TRK-820 on cloned μ-, δ-and κ–opiod Receptors and nociceptin Receptor
Agonist-dependent desensitization of the κ opiod Receptor by G protein Receptor kinase and β-arrestin
The κ opiod Receptor and food intake
Identification of short-acting κ–opiod Receptor antagonists with anxiolytic-like activity
Hypothalamic κ–opiod Receptor modulates the orexigenic effect of ghrelin
Cardioprotection of preconditioning by metabolic inhibition in the rat ventricular myocyte: involvement of κ–opiod Receptor
Central nicotine induces browning through hypothalamic κ opiod Receptor
Central κ–opiod Receptor-mediated antidepressant-like effects of nor-Binaltorphimine: Behavioral and BDNF mRNA expression studies
Antagonists of the κ‐opiod Receptor enhance allodynia in rats and mice after sciatic nerve ligation
A regulatory variation in OPRK1, the gene encoding the κ–opiod Receptor, is associated with alcohol dependence
κ–opiod Receptor-transfected cell lines: modulation of adenylyl cyclase activity following acute and chronic opiod treatments
κ–opiod Receptor agonist U50, 488H modulates cocaine and morphine self-administration in drug-naive rats and mice
Hypoxia induces internalization of κ–opiod Receptor
Immunomodulatory action of class μ, δ-and κ–opiod Receptor agonists in mice
L-type Ca2+ channel modulation by dihydropyridines potentiates κ–opiod Receptor agonist induced acute analgesia and inhibits development of tolerance in rats
Immunosuppression by δ-opiod antagonist naltrindole: δ-and triple μ/δ/κ–opiod Receptor knockout mice reveal a nonopiod activity
Exposure to the selective κ–opiod Receptor agonist salvinorin A modulates the behavioral and molecular effects of cocaine in rats
Analgesic efficacy of peripheral κ–opiod Receptor agonist CR665 compared to oxycodone in a multi-modal, multi-tissue experimental human pain model: selective …
Copb1-facilitated axonal transport and translation of κ opiod–Receptor mRNA
Pulsed magnetic field induced “analgesia” in the land snail, Cepaea nemoralis, and the effects of μ, δ, and κ opiod Receptor agonists/antagonists
Increased κ–opiod Receptor expression and function during chronic visceral hypersensitivity
Role of κ–opiod Receptor activation in pharmacological preconditioning of swine
Antidepressive effects of the κ–opiod Receptor agonist salvinorin A in a rat model of anhedonia
Region selective up-regulation of μ-, δ-and κ–opiod Receptors but not opiod Receptor-like 1 Receptors in the brains of enkephalin and dynorphin knockout mice
Stimulation of κ–opiod Receptor reduces isoprenaline-induced cardiac hypertrophy and fibrosis
Targeting opiod Receptor signaling in depression: do we need selective κ opiod Receptor antagonists?
κ–opiod Receptor activation in dopamine neurons disrupts behavioral inhibition
In situ hybridization study of μ-and κ–opiod Receptor mRNAs in the rat spinal cord and dorsal root ganglia
Chemical coding of neurons expressing δ-and κ–opiod Receptor and type I vanilloid Receptor immunoreactivities in the porcine ileum
Behavioral stress may increase the rewarding valence of cocaine-associated cues through a dynorphin/κ–opiod Receptor-mediated mechanism without …
Allosterism within δ opiod–κ opiod Receptor Heteromers in Peripheral Sensory Neurons: Regulation of κ opiod Agonist Efficacy
κ–opiod Receptor agonist suppression of HIV-1 expression in CD4+ lymphocytes
Discovery and pharmacological evaluation of a diphenethylamine derivative (HS665), a highly potent and selective κ opiod Receptor agonist
Receptor occupancy of the κ–opiod antagonist LY2456302 measured with positron emission tomography and the novel radiotracer 11C-LY2795050
Axonal mRNA transport and localized translational regulation of κ–opiod Receptor in primary neurons of dorsal root ganglia
Pharmacological activities of optically pure enantiomers of the κ opiod agonist, U50, 488, and its cis diastereomer: evidence for three κ Receptor subtypes
κ–opiod Receptor stimulation modulates TLR4/NF-κB signaling in the rat heart subjected to ischemia–reperfusion
Regulation of mouse κ opiod Receptor gene expression by retinoids
Evidence that nalorphine, butorphanol and oxilorphan are partial agonists at a κ–opiod Receptor
The macrocyclic tetrapeptide [D‐T rp] CJ‐15,208 produces short‐acting κ opiod Receptor antagonism in the CNS after oral administration
Effects of peripherally restricted κ opiod Receptor agonists on pain-related stimulation and depression of behavior in rats
κ opiod Receptor-mediated analgesia in the developing rat
Antiarrhythmic effect mediated by κ–opiod Receptor is associated with Cx43 stabilization
Phosphatidylinositol‐3 kinase is distinctively required for µ‐, but not κ‐opiod Receptor‐induced activation of c‐Jun N‐terminal kinase
κ–opiod Receptor participates of NSAIDs peripheral antinociception
Selective changes in μ, δ and ϰ opiod Receptor binding in certain limbic regions of the brain in Alzheimer’s disease patients
Sequence of κ–opiod Receptor cDNA in the R1. 1 thymoma cell line
Development of novel quinoxaline-based κ–opiod Receptor agonists for the treatment of neuroinflammation
Prodynorphin, proenkephalin and κ opiod Receptor mRNA responses to acute “binge” cocaine
Effects of atypical κ–opiod Receptor agonists on intrathecal morphine-induced itch and analgesia in primates
Repeated stress dysregulates κ–opiod Receptor signaling in the dorsal raphe through a p38α MAPK-dependent mechanism
Molecular switches of the κ opiod Receptor triggered by 6′-GNTI and 5′-GNTI
Sodium channel blocking actions of the κ–opiod Receptor agonist U50, 488 contribute to its visceral antinociceptive effects
Sensitization to the conditioned rewarding effects of morphine and cocaine: differential effects of the κ–opiod Receptor agonist U69593
An electrophysiological basis for the antiarrhythmic actions of the κ–opiod Receptor agonist U-50,488 H
In situ hybridization study of κ–opiod Receptor mRNA in the rat brain
Effects of a newly synthesized κ–opiod Receptor agonist, TRK-820, on the discriminative stimulus and rewarding effects of cocaine in rats
Corticotropin-releasing factor (CRF)-induced disruption of attention in rats is blocked by the κ–opiod Receptor antagonist JDTic
Effects of the κ–opiod Receptor agonist U-50,488 on morphine-induced place preference conditioning in the developing rat
opiod Receptor-mediated suppression of humoral immune response in vivo and in vitro: involvement of κ opiod Receptors
Lack of cross-tolerance between U69, 593 and bremazocine suggest κ–opiod Receptor multiplicity in mice
Impact of pharmacological manipulation of the κ–opiod Receptor system on self-grooming and anhedonic-like behaviors in male mice
Test–retest reproducibility of binding parameters in humans with 11C-LY2795050, an antagonist PET radiotracer for the κ opiod Receptor
Effects of peripheral κ opiod Receptor activation on inflammatory mechanical hyperalgesia in male and female rats
μ-, δ-, and κ–opiod Receptor agonists selectively modulate sexual behaviors in the female rat: differential dependence on progesterone
Structure and expression of a rat κ opiod Receptor gene
Myocardial apoptosis and infarction after ischemia/reperfusion are attenuated by κ–opiod Receptor agonist
Investigation of inactive-state κ opiod Receptor homodimerization via single-molecule microscopy using new antagonistic fluorescent probes
N-Glycosylation of the Human κ opiod Receptor Enhances Its Stability but Slows Its Trafficking along the Biosynthesis Pathway
Further evidence for the implication of a κ–opiod Receptor mechanism in the production of psychological stress-induced analgesia
Toosendanin-induced apoptosis in colorectal cancer cells is associated with the κ–opiod Receptor/β-catenin signaling axis
κ–opiod Receptor expression defines a phenotypically distinct subpopulation of astroglia: relationship to Ca2+ mobilization, development, and the antiproliferative …
Feeding responses to μ-, δ-and κ–opiod Receptor agonists in the meat-type chick
κ–opiod Receptor activation promotes mitochondrial fusion and enhances myocardial resistance to ischemia and reperfusion injury via STAT3-OPA1 pathway
Constraining endomorphin-1 by β, α-hybrid dipeptide/heterocycle scaffolds: identification of a novel κ–opiod Receptor selective partial agonist
G protein signaling–biased agonism at the κ–opiod Receptor is maintained in striatal neurons
Dynorphin and κ–opiod Receptor dysregulation in the dopaminergic reward system of human alcoholics
Identification of the three-dimensional pharmacophore of κ–opiod Receptor agonists
Antinociceptive and Adverse Effects of µ‐and κ‐opiod Receptor Agonists: A Comparison of Morphine and U50488‐H
Conformational analysis and automated Receptor docking of selective arylacetamide-based κ–opiod agonists
Beneficial effects of the κ opiod Receptor agonist U-50488H in experimental acute brain and spinal cord injury
Effect of κ–opiod Receptor agonist on the growth of non-small cell lung cancer (NSCLC) cells
An improved antagonist radiotracer for the κ–opiod Receptor: Synthesis and characterization of 11C-LY2459989
κ–opiod Receptor agonists modulate visceral nociception at a novel, peripheral site of action
Visualizing preference of G protein-coupled Receptor kinase 3 for the process of κ–opiod Receptor sequestration
μ-, δ-and κ–opiod Receptor-mediated inhibition of neurotransmitter release and adenylate cyclase activity in rat brain slices: studies with fentanyl isothiocyanate
Sex difference in κ–opiod Receptor (KOPR)-mediated behaviors, brain region KOPR level and KOPR-mediated guanosine 5′-O-(3-[35S] thiotriphosphate) binding in …
Early role of the κ opiod Receptor in ethanol-induced reinforcement
Structure–Activity Relationships of [des-Arg7]Dynorphin A Analogues at the κ opiod Receptor
Prodynorphin and κ opiod Receptor mRNA expression in the cingulate and prefrontal cortices of subjects diagnosed with schizophrenia or affective disorders
Post-transcriptional regulation of mouse κ–opiod Receptor expression
Trial-selective effects of U50, 488H, a κ–opiod Receptor agonist, on consummatory successive negative contrast
Development and in vivo evaluation of a κ–opiod Receptor agonist as a PET radiotracer with superior imaging characteristics
Anti-arrhythmic effect of κ–opiod Receptor stimulation in the perfused rat heart: involvement of a cAMP-dependent pathway
Anti‐nociception mediated by a κ opiod Receptor agonist is blocked by a δ Receptor agonist
Voluntary ethanol intake predicts κ–opiod Receptor supersensitivity and regionally distinct dopaminergic adaptations in macaques
Spinal κ–opiod Receptor-mediated antinociception is stimulus-specific
Characterization of a Knock-In Mouse Line Expressing a Fusion Protein of κ opiod Receptor Conjugated with tdTomato: 3-Dimensional Brain Imaging via …
Neuroanatomical and neuropharmacological study of opiod pathways in the mesencephalic tectum: effect of μ1-and κ–opiod Receptor blockade on escape behavior …
Regulation of κ–opiod Receptor signaling in peripheral sensory neurons in vitro and in vivo
Activity profiles of dalargin and its analogues in μ‐, δ‐ and κ‐opiod Receptor selective bioassays
Elucidation of conformational states, dynamics, and mechanism of binding in human κ–opiod Receptor complexes
Modeling of κ–opiod Receptor/agonists interactions using pharmacophore-based and docking simulations
Prenatal ethanol increases ethanol intake throughout adolescence, alters ethanol‐mediated aversive learning, and affects μ but not δ or κ opiod Receptor mRNA …
Presence of μ and κ opiod Receptor mRNAs in galanin but not in GnRH neurons in the female rat
Prolonged opportunity for ischemic neuroprotection with selective κ–opiod Receptor agonist in rats
Hyaluronic acid induces activation of the κ–opiod Receptor
The novel κ–opiod Receptor agonist TRK-820 suppresses the rewarding and locomotor-enhancing effects of morphine in mice
Characterization of κ–opiod Receptor transcripts expressed by T cells and macrophages
8-epi-Salvinorin B: crystal structure and affinity at the κ opiod Receptor
Suppression of cAMP by phosphoinositol/Ca2+ pathway in the cardiac κ–opiod Receptor
Endogenous κ opiod Receptor Systems Modulate the Responsiveness of Mesoaccumbal Dopamine Neurons to Ethanol
Effects of κ–opiod Receptor agonists on long-term cocaine use and dopamine neurotransmission
Blockade of U50, 488H analgesia by antisense oligodeoxynucleotides to a κ–opiod Receptor
Intrinsic relative activities of κ opiod agonists in activating Gα proteins and internalizing Receptor: Differences between human and mouse Receptors
… of CYX-6, a potent μ-opiod Receptor agonist, a δ-and κ–opiod Receptor antagonist and a biased ligand at μ, δ & κ–opiod Receptors, evokes antinociception with …
U-50,488 H, a κ–opiod Receptor agonist, markedly prevents memory dysfunctions induced by transient cerebral ischemia in mice
Butorphanol dependence increases hippocampal κ‐opiod Receptor gene expression
Buprenorphine is an Antagonist at the ϰ opiod Receptor
κ–opiod Receptor modulation of accumbal dopamine concentration during operant ethanol self-administration
Effects of κ‐opiod Receptor stimulation in the heart and the involvement of protein kinase C
Differential effects of μ-, δ-, and κ–opiod Receptor agonists on mechanosensitive gastric vagal afferent fibers in the rat
Antisense oligodeoxynucleotide to a δ-opiod Receptor selectivily blocks the spinal antinociception induced by δ-, but not μ-or κ–opiod Receptor agonists in the mouse
The protective effects of κ–opiod Receptor stimulation in hypoxic pulmonary hypertension involve inhibition of autophagy through the AMPK-MTOR pathway
Response of neuropeptide Y-induced feeding to μ-, δ-and κ–opiod Receptor antagonists in the neonatal chick
Design of a stable cyclic peptide analgesic derived from sunflower seeds that targets the κ–opiod Receptor for the treatment of chronic abdominal pain
Effect of repeated administration of TRK-820, a κ–opiod Receptor agonist, on tolerance to its antinociceptive and sedative actions
Tyrosine phosphorylation of Kir3 following κ–opiod Receptor activation of p38 MAPK causes heterologous desensitization
Design, synthesis and biological evaluation of aminobenzyloxyarylamide derivatives as selective κ opiod Receptor antagonists
Roles of KATP channels in delayed cardioprotection and intracellular Ca2+ in the rat heart as revealed by κ‐opiod Receptor stimulation with U50,488H
N-methylacetamide analog of salvinorin A: a highly potent and selective κ–opiod Receptor agonist with oral efficacy
Localization of κ–opiod Receptor mRNA in neuronal subpopulations of rat sensory ganglia and spinal cord
κ–opiod Receptor activation protects against myocardial ischemia-reperfusion injury via AMPK/Akt/eNOS signaling activation
Analyzing interaction of μ-, δ-and κ–opiod Receptor gene variants on alcohol or drug dependence using a pattern discovery-based method
… morphine administration causes differential long-lasting changes in dopaminergic neurotransmission in rat striatum without changing its δ-and κ–opiod Receptor …
NMR and modeling studies of a synthetic extracellular loop II of the κ opiod Receptor in a DPC micelle
Down-regulation of the tumour suppressor κ–opiod Receptor predicts poor prognosis in hepatocellular carcinoma patients
Syntheses of immobilized G protein-coupled Receptor chromatographic stationary phases: characterization of immobilized μ and κ opiod Receptors
Determination of sites of U50, 488H-promoted phosphorylation of the mouse κ opiod Receptor (KOPR): disconnect between KOPR phosphorylation and internalization
Cloning and promoter mapping of mouse κ opiod Receptor gene
Central and peripheral actions of the novel κ‐opiod Receptor agonist, EMD 60400
Mouse κ–opiod Receptor mRNA differential transport in neurons
Electroacupuncture relieves labour pain and influences the spinal dynorphin/κ–opiod Receptor system in rats
Novel 18F-labeled κ–opiod Receptor antagonist as PET radiotracer: synthesis and in vivo evaluation of 18F-LY2459989 in nonhuman primates
Effects of salvinorin A, a κ–opiod hallucinogen, on a neuroendocrine biomarker assay in nonhuman primates with high κ–Receptor homology to humans
… -50/Na+/H+ exchanger regulatory factor (EBP50/NHERF) blocks U50, 488H-induced down-regulation of the human κ opiod Receptor by enhancing its …
κ–opiod Receptor gene as a predictor of response in a cocaine vaccine clinical trial
Differential regulation of the human κ opiod Receptor by agonists: etorphine and levorphanol reduced dynorphin A-and U50, 488H-induced internalization and …
Effects of the local administration of selective μ-, δ-and κ–opiod Receptor agonists on osteosarcoma-induced hyperalgesia
μ‐opiod Agonist Inhibition of κ‐opiod Receptor‐Stimulated Extracellular Signal‐Regulated Kinase Phosphorylation Is Dynamin‐Dependent in C6 Glioma Cells
Comparison of G-protein activation in the brain by μ-, δ-, and κ–opiod Receptor agonists in μ-opiod Receptor knockout mice
Drug design and synthesis of a novel κ opiod Receptor agonist with an oxabicyclo [2.2. 2] octane skeleton and its pharmacology
Distribution of κ‐opiod Receptor in the Pulmonary Artery and its Changes During Hypoxia
Neuroprotective κ–opiod Receptor agonist BRL 52537 attenuates ischemia-evoked nitric oxide production in vivo in rats
Cu-Catalyzed N-arylation of oxazolidinones: An efficient synthesis of the κ–opiod Receptor agonist CJ-15161
Novel malonamide derivatives as potent κ opiod Receptor agonists
Changes in the brain κ–opiod Receptor levels of rats in withdrawal from physical dependence upon butorphanol
Effects of heat shock protein 70 activation by metabolic inhibition preconditioning or κ–opiod Receptor stimulation on Ca2+ homeostasis in rat ventricular myocytes …
Identification of arodyn, a novel acetylated dynorphin A-(1− 11) analogue, as a κ opiod Receptor antagonist
Effects of intrathecal κ–opiod Receptor agonist on morphine-induced itch and antinociception in mice
μ but not δ and κ opiod Receptor involvement in ventrolateral orbital cortex opiod-evoked antinociception in formalin test rats
Quaternary ammonium salt of U50488H, a new κ–opiod Receptor agonist, protects rat heart against ischemia/reperfusion injury
Heterologous µ‐opiod Receptor adaptation by repeated stimulation of κ‐opiod Receptor: up‐regulation of G‐protein activation and antinociception
In vivo and in vitro characterization of naltrindole-derived ligands at the κ–opiod Receptor
Effects of morphine in rats treated chronically with U-50,488 H, a κ opiod Receptor agonist
Peripheral component in the enhanced antinociceptive effect of systemic U-69,593, a κ–opiod Receptor agonist in mononeuropathic rats
Changes in spinal δ and κ opiod systems in mice deficient in the A2A Receptor gene
Stimulation of mitogen-activated protein kinase kinases (MEK1/2) by μ-, δ-and κ–opiod Receptor agonists in the rat brain: Regulation by chronic morphine and opiod …
Gastric effects of μ-, δ-and κ–opiod Receptor agonists on brainstem unitary responses in the neonatal rat
δ, μ, and κ opiod Receptor agonists inhibit dopamine overflow in rat neostriatal slices
Pharmacological properties of R-84760, a novel κ–opiod Receptor agonist
Amygdalar κ–opiod Receptor-dependent upregulating glutamate transporter 1 mediates depressive-like behaviors of opiod abstinence
Complete knockout of the nociceptin/orphanin FQ Receptor in the rat does not induce compensatory changes in μ, δ and κ opiod Receptors
Determination of the in vivo selectivity of a new κ–opiod Receptor antagonist PET tracer 11C-LY2795050 in the rhesus monkey
Highly potent and selective new diphenethylamines interacting with the κ–opiod Receptor: synthesis, pharmacology, and structure–activity relationships
Analysis of the antinociceptive actions of the κ–opiod agonist enadoline (CI-977) in neonatal and adult rats: comparison to κ–opiod Receptor mRNA ontogeny
Antinociceptive effect of a κ–opiod Receptor agonist that minimally crosses the blood-brain barrier (ICI 204448) in a rat model of mononeuropathy
Chronic food restriction alters μ and κ opiod Receptor binding in the parabrachial nucleus of the rat: a quantitative autoradiographic study
Agonist-Dependent and-Independent κ opiod Receptor phosphorylation: distinct phosphorylation patterns and different cellular outcomes
Increased responsiveness of mesolimbic and mesostriatal dopamine neurons to cocaine following repeated administration of a selective κ‐opiod Receptor agonist
κ–opiod Receptor effects of butorphanol in rhesus monkeys
The association of genetic polymorphisms in the κ–opiod Receptor 1 gene with body weight, alcohol use, and withdrawal symptoms in patients with methadone …
Chronic cocaine increases κ‐opiod Receptor density: Lack of effect by selective dopamine uptake inhibitors
N-Alkyl-octahydroisoquinolin-1-one-8-carboxamides: Selective and Nonbasic κ–opiod Receptor Ligands
κ–opiod Receptor blockade with nor-binaltorphimine modulates cocaine self-administration in drug-naive rats
Effects of κ–opiod Receptor activation on myocardium
Discovery of a Highly Selective and Potent κ opiod Receptor Agonist from N-Cyclopropylmethyl-7α-phenyl-6,14-endoethanotetrahydronorthebaines with Reduced …
Up-regulation of RGS4 mRNA by opiod Receptor agonists in PC12 cells expressing cloned μ-or κ–opiod Receptors
Antisense confirmation of μ-and κ–opiod Receptor mediation of morphine’s effects on body temperature in rats
A highly selective κ–opiod Receptor agonist with low addictive potential and dependence liability
Studies of dual promoters of mouse κ–opiod Receptor gene
Enadoline, a selective κ–opiod Receptor agonist shows potent antihyperalgesic and antiallodynic actions in a rat model of surgical pain
κ–opiod Receptor stimulation reduces palmitate-induced apoptosis via Akt/eNOS signaling pathway
Xylazine induced central antinociception mediated by endogenous opiods and μ-opiod Receptor, but not δ-or κ–opiod Receptors
Purification and mass spectrometric analysis of the κ opiod Receptor
κ–opiod Receptor stimulation improves endothelial function via Akt-stimulated NO production in hyperlipidemic rats
Ischemic neuroprotection with selective κ–opiod Receptor agonist is gender specific
κ–opiod Receptor as a key mediator in the regulation of appetitive 50-kHz ultrasonic vocalizations
[11C]-MeJDTic: a novel radioligand for κ–opiod Receptor positron emission tomography imaging
Novel signaling of dynorphin at κ–opiod Receptor/bradykinin B2 Receptor heterodimers
… helical orientations among related G protein-coupled Receptors provide a novel mechanism for selectivity: studies with salvinorin A and the κ–opiod Receptor
κ opiod Receptor activation in different brain regions differentially modulates anxiety-related behaviors in mice
Involvement of the κ–opiod Receptor in nitrous oxide-induced analgesia in mice
Dissociable effects of the κ–opiod Receptor agonists bremazocine, U69593, and U50488H on locomotor activity and long-term behavioral sensitization induced by …
Synthesis of an affinity ligand (‘UPHIT’) for in vivo acylation of the κ–opiod Receptor
opiods in cancer: The κ‑opiod Receptor
Netrin-1 signaling regulates de novo protein synthesis of κ opiod Receptor by facilitating polysomal partition of its mRNA
Differential effects of μ-, δ-and κ–opiod Receptor agonists on the discriminative stimulus properties of cocaine in rats
κ–opiod Receptor stimulation increases intracellular free calcium in isolated rat ventricular myocytes
κ–opiod Receptor in the nucleus is a novel prognostic factor of esophageal squamous cell carcinoma
Effects of JDTic, a selective κ–opiod Receptor antagonist, on the development and expression of physical dependence on morphine using a rat continuous-infusion …
Effects of Peripheral μ, δ, and κ–opiod Receptor Agonists on the Levels of Anxiety and Motor Activity of Rats
Differential κ–opiod Receptor expression on mouse lymphocytes at varying stages of maturation and on mouse macrophages after selective elicitation
Modulation of glutamate release by a κ–opiod Receptor agonist in rodent and primate striatum
Azepinone as a conformational constraint in the design of κ–opiod Receptor agonists
Anticonvulsive effects of κ‐opiod Receptor modulation in an animal model of ethanol withdrawal
κ–opiod Receptor stimulation improves endothelial function in hypoxic pulmonary hypertension
Plant-Derived Cyclotides Modulate κ–opiod Receptor Signaling
Modulation of humoral immune response by central administration of leucine-enkephalin: Effects of μ, δ and κ opiod Receptor antagonists
2, 4-Substituted bispidines as rigid hosts for versatile applications: from κ–opiod Receptor to metal coordination
Anti-arrhythmic effects of κ–opiod Receptor and its changes in ischemia and reperfusion
κ–opiod Receptor ligands inhibit cocaine-induced HIV-1 expression in microglial cells
μ and κ opiod Receptor distribution in the monogamous titi monkey (Callicebus cupreus): Implications for social behavior and endocrine functioning
[Nα-BenzylTyr,cyclo(d-Asp5,Dap8)]- dynorphin A-(1−11)NH2 Cyclized in the “Address” Domain Is a Novel κ–opiod Receptor Antagonist
Effects of U-50,488 H, a κ–opiod Receptor agonist, on the learned helplessness model of depression in mice
The selective κ–opiod Receptor agonist U50, 488 reduces L-dopa-induced dyskinesias but worsens parkinsonism in MPTP-treated primates
Evidence for coupling of the κ opiod Receptor to brain GTPase
A novel κ–opiod Receptor agonist, TRK-820, blocks the development of physical dependence on morphine in mice
κ–opiod Receptor signals through Src and focal adhesion kinase to stimulate c-Jun N-terminal kinases in transfected COS-7 cells and human monocytic THP-1 cells
Ligands regulate cell surface level of the human κ opiod Receptor by activation-induced down-regulation and pharmacological chaperone-mediated enhancement …
Reactive oxygen species (ROS) generation is stimulated by κ opiod Receptor activation through phosphorylated c-Jun N-terminal kinase and inhibited by p38 …
The effect of activated κ–opiod Receptor (κ-OR) on the role of calcium sensing Receptor (CaSR) in preventing hypoxic pulmonary hypertension development
κ–opiod Receptor mediates the antinociceptive effect of nitrous oxide in mice
Retinoic acid-induced chromatin remodeling of mouse κ opiod Receptor gene
Antagonism of κ opiod Receptor in the nucleus accumbens prevents the depressive-like behaviors following prolonged morphine abstinence
κ–opiod Receptor model in a phospholipid bilayer: Molecular dynamics simulation
Cardioprotection with κ–opiod Receptor stimulation is associated with a slowing of cross-bridge cycling
Influence of asimadoline, a new κ‐opiod Receptor agonist, on tubular water absorption and vasopressin secretion in man
Peripheral neuronal nitric oxide synthase activity mediates the antinociceptive effect of Crotalus durissus terrificus snake venom, a δ-and κ–opiod Receptor agonist
The adrenergic Receptor agonist, clonidine, potentiates the anti‐parkinsonian action of the selective κ‐opiod Receptor agonist, enadoline, in the monoamine‐depleted …
Amygdala dynorphin/κ opiod Receptor system modulates depressive-like behavior in mice following chronic social defeat stress
RGS2 and RGS4 proteins: New modulators of the κ–opiod Receptor signaling
Disability of development of tolerance to morphine and U-50,488 H, a selective κ–opiod Receptor agonist, in neuropathic pain model mice
… effect of a benzilidine-cyclohexanone analogue on a mouse model of chronic constriction injury-induced neuropathic pain: Participation of the κ–opiod Receptor and …
κ–opiod regulation of thymocyte IL-7 Receptor and CC chemokine Receptor 2 expression
Synthesis and Pharmacological Evaluation of Fluorinated Quinoxaline‐Based κ‐opiod Receptor (KOR) Agonists Designed for PET Studies
Variants of κ–opiod Receptor gene and mRNA in alcohol-preferring and alcohol-avoiding mice
Differentiation of δ, μ, and κ opiod Receptor agonists based on pharmacophore development and computed physicochemical properties
The anticonvulsant action of CI-977, a selective κ–opiod Receptor agonist: a possible involvement of the glycine/NMDA Receptor complex
A novel signaling pathway of nitric oxide on transcriptional regulation of mouse κ opiod Receptor gene
… to confer cardioprotection and to increase the expression of heat-shock protein 70 by preconditioning with a κ–opiod Receptor agonist during ischaemia and …
Effect of μ and κ opiod Receptor agonists on rat plasma corticosterone levels
Activity of the δ-opiod Receptor is partially reduced, whereas activity of the κ–Receptor is maintained in mice lacking the μ-Receptor
… neurotoxicity in mice via upregulation of dynorphin-mediated κ–opiod Receptor and downregulation of substance P-mediated neurokinin 1 Receptor
Tyrosine phosphorylation of the κ–opiod Receptor regulates agonist efficacy
Current κ opiod Receptor ligands and discovery of a new molecular scaffold as a κ opiod Receptor antagonist using pharmacophore-based virtual screening
… of GEC1 protein and γ-aminobutyric acid type A (GABAA) Receptor-associated protein (GABARAP), two microtubule-associated proteins, on κ opiod Receptor …
Design and Synthesis of Enantiomerically Pure Decahydroquinoxalines as Potent and Selective κ–opiod Receptor Agonists with Anti-Inflammatory Activity in Vivo
Discovery of peripheral κ–opiod Receptor agonists as novel analgesics
GEC1-κ opiod Receptor binding involves hydrophobic interactions: GEC1 has chaperone-like effect
Molecular modeling study of the differential ligand–Receptor interaction at the μ, δ and κ opiod Receptors
Study of the involvement of K+ channels in the peripheral antinociception of the κ–opiod Receptor agonist bremazocine
Regulation of mouse κ opiod Receptor gene expression by different 3′-untranslated regions and the effect of retinoic acid
κ–opiod Receptor is involved in the cardioprotection induced by exercise training
The G‐protein biased partial κ opiod Receptor agonist 6′‐GNTI blocks hippocampal paroxysmal discharges without inducing aversion
… behavior in MRL/lpr mice, a possible model for pruritus in autoimmune diseases, and antipruritic activity of a novel κ–opiod Receptor agonist nalfurafine hydrochloride
The μ-opiod activity of κ–opiod Receptor agonist compounds in the guinea pig ileum
Cellular distribution of the mRNA for the κ–opiod Receptor in the human neocortex: a non-isotopic in situ hybridization study
In Vivo Modulation of Post‐Spike Excitability in Vasopressin Cells by κ‐opiod Receptor Activation
Topical κ‐opiod Receptor agonist asimadoline improves dermatitis in a canine model of atopic dermatitis
Lack of effect of γ-hydroxybutyrate on μ, δ and κ opiod Receptor binding
Role of κ—opiod Receptor in Hypoxic Pulmonary Artery Hypertension and Its Underlying Mechanism
Treatment of cocaine craving with as-needed nalmefene, a partial κ opiod Receptor agonist: first clinical experience
G protein coupled Receptor kinase-2 upregulation causes κ–opiod Receptor desensitization in diabetic heart
Identity of the putative δ1-opiod Receptor as a δ–κ heteromer in the mouse spinal cord
U-50488H, a selective κ–opiod Receptor agonist, improves carbon monoxide-induced delayed amnesia in mice
A population pharmacokinetic and pharmacodynamic study of a peripheral κ–opiod Receptor agonist CR665 and oxycodone
Protein kinase C-ε is a trigger of delayed cardioprotection against myocardial ischemia of κ–opiod Receptor stimulation in rat ventricular myocytes
μ-and κ–opiod Receptor agonists produce peripheral inhibition of neurogenic plasma extravasation in rat skin
A highly selective κ–opiod Receptor agonist, CI-977, reduces excitatory synaptic potentials in the rat locus coeruleus in vitro
κ–opiod Receptor inhibition of calcium oscillations in spinal cord neurons
A select set of opiod ligands induce up-regulation by promoting the maturation and stability of the rat κ–opiod Receptor in human embryonic kidney 293 cells
Synthesis, biological evaluation, and Receptor docking simulations of 2-[(acylamino) ethyl]-1, 4-benzodiazepines as κ–opiod Receptor agonists endowed with …
Modulation of the Neurotoxic Effects of Methamphetamine by the Selective κ‐opiod Receptor Agonist U69593
Investigation of the μ‐and κ‐opiod Receptor activation by eight new synthetic opiods using the [35S]‐GTPγS assay: U‐47700, isopropyl U‐47700, U‐49900, U …
Novel κ–opiod Receptor agonist MB-1C-OH produces potent analgesia with less depression and sedation
Activation of the κ–opiod Receptor in Caco-2 cells decreases interleukin-8 secretion
Inhibitory and excitatory effects of μ-, δ-, and κ–opiod Receptor activation on breathing in awake turtles, Trachemys scripta
Neurofilament proteins and cAMP pathway in brains of μ-, δ-or κ–opiod Receptor gene knock-out mice: effects of chronic morphine administration
Design, synthesis and biological evaluation of N-hydroxy-aminobenzyloxyarylamide analogues as novel selective κ opiod Receptor antagonists
κ opiod Receptor interacts with Na+/H+-exchanger regulatory factor-1/Ezrin-radixin-moesin-binding phosphoprotein-50 (NHERF-1/EBP50) to stimulate Na+ …
Stress-induced epigenetic regulation of κ–opiod Receptor gene involves transcription factor c-Myc
κ–opiod Receptor stimulation inhibits growth of neonatal rat ventricular myocytes
Synthesis and evaluation of novel peripherally restricted κ–opiod Receptor agonists
The novel κ–opiod Receptor agonist TRK-820 has no affect on the development of antinociceptive tolerance to morphine in mice
Butorphanol alleviates lipopolysaccharide‑induced inflammation and apoptosis of cardiomyocytes via activation of the κ‑opiod Receptor
The κ–opiod Receptor is involved in the stimulating effect of nicotine on adrenocortical activity but not in nicotine induced anxiety
Functional evidence for interaction between prostaglandin EP3 and κ–opiod Receptor pathways in tactile pain induced by human immunodeficiency virus type-1 (HIV-1 …
Arylacetamide κ–opiod Receptor agonists produce a tonic-and use-dependent block of tetrodotoxin-sensitive and-resistant sodium currents in colon sensory neurons
Potentiation of κ–opiod Receptor agonist-induced analgesia and hypothermia by fluoxetine
Apparent efficacy of κ–opiod Receptor ligands on serum prolactin levels in rhesus monkeys
Blockade of the morphine-induced increase in turnover of dopamine on the mesolimbic dopaminergic system by κ–opiod Receptor activation in mice
Synthesis and absolute configuration of optically pure enantiomers of a ϰ‐opiod Receptor selective agonist
Na+ ions and Gpp (NH) p selectively inhibit agonist interactions at μ-and κ–opiod Receptor sites in rabbit and guinea-pig cerebellum membranes
Effects of μ-, δ-and κ–opiod Receptor agonists on methamphetamine-induced self-injurious behavior in mice
Early ontogeny of κ–opiod Receptor regulation of prolactin secretion in the rat
Separation of κ–opiod Receptor subtype from frog brain
Transcriptional regulation of the major HIV‐1 coReceptor, CXCR4, by the κ opiod Receptor
κ–opiod Receptor stimulation inhibits cardiac hypertrophy induced by β1-adrenoceptor stimulation in the rat
The effect of κ–opiod Receptor agonists on tetrodotoxin-resistant sodium channels in primary sensory neurons
The role of phosphodiesterase in mediating the effect of protein kinase C on cyclic AMP accumulation upon κ–opiod Receptor stimulation in the rat heart
Synthesis and pharmacology of a novel κ opiod Receptor (KOR) agonist with a 1, 3, 5-trioxazatriquinane skeleton
Mitochondrial dysfunction and apoptosis are attenuated on κ–opiod Receptor activation through AMPK/GSK-3β pathway after myocardial ischemia and reperfusion
Expression of κ–opiod Receptor mRNA in human peripheral blood lymphocytes and the relationship between its expression and the inflammatory changes in …
Impaired [Ca2+]i and pHiresponses to κ–opiod Receptor stimulation in the heart of chronically hypoxic rats
Discovery of N-methyltetrahydroprotoberberines with κ–opiod Receptor agonists-opiod Receptor agonist activities from corydalis yanhusuo WT Wang by using two …
Spontaneous excitatory currents and κ–opiod Receptor inhibition in dentate gyrus are increased in the rat pilocarpine model of temporal lobe epilepsy
Nalfurafine hydrochloride, a selective κ opiod Receptor agonist, has no reinforcing effect on intravenous self-administration in rhesus monkeys
… 17-cyclopropylmethyl-3, 14β-dihydroxy-4, 5α-epoxy-6β-[(4′-pyridyl) carboxamido] morphinan (NAP) derivatives as μ/κ opiod Receptor dual selective ligands
Regulation of κ–opiod Receptor mRNA level by cyclic AMP and growth factors in cultured rat glial cells
Structural determinants of diphenethylamines for interaction with the κ opiod Receptor: Synthesis, pharmacology and molecular modeling studies
Baicalein protects chicken embryonic cardiomyocyte against hypoxia–reoxygenation injury via μ-and δ-but not κ–opiod Receptor signaling
Effects of U-69,593, a κ–opiod Receptor agonist, on carrageenin-induced peripheral oedema and Fos expression in the rat spinal cord
κ–opiod Receptor potentiates apoptosis via a phospholipase C pathway in the CNE2 human epithelial tumor cell line
Cholecystokinin octapeptide reverses the κ–opiod–Receptor-mediated depression of calcium current in rat dorsal root ganglion neurons
κ–opiod Receptor antagonism reverses heroin withdrawal-induced hyperalgesia in male and female rats
Hypericum perforatum inhibits the binding of μ-and κ–opiod Receptor expressed with the Semliki Forest virus system
Hypertensive state, independent of hypertrophy, exhibits an attenuated decrease in systolic function on cardiac κ–opiod Receptor stimulation
Effects of acute agonist treatment on subcellular distribution of κ opiod Receptor in rat spinal cord
κ–opiod Receptor modulation of GABAergic inputs onto ventrolateral periaqueductal gray dopamine neurons
Arylacetamide κ opiod Receptor agonists with reduced cytochrome P450 2D6 inhibitory activity
µ-and κ–opiod Receptor activation in the dorsal periaqueductal grey matter differentially modulates panic-like behaviours induced by electrical and chemical …
κ–opiod Receptor stimulation inhibits augmentation of Ca2+ transient and hypertrophy induced by isoprenaline in neonatal rat ventricular myocytes—Role of …
Effects of ibogaine on the development of tolerance to antinociceptive action of μ-, δ-and κ–opiod Receptor agonists in mice
Effect of μ, δ and κ opiod Receptor agonists on a reactive oxygen species mediated model of skin inflammation
κ–opiod Receptor agonist-induced prolactin release in primates is blocked by dopamine D2-like Receptor agonists
Gi1 and GoA differentially determine kinetic efficacies of agonists for κ–opiod Receptor
The NMDA Receptor antagonist MK-801 differentially modulates μ and κ opiod actions in spinal cord in vitro
The κ–opiod Receptor expressed on the mouse lymphoma cell line R1. 1 contains a sulfhydryl group at the binding site
… to a δ-opiod Receptor messenger rna selectively blocks the antinociception induced by intracerebroventricularly administered δ-, but not μ-, ϵ-, or κ–opiod Receptor …
Conformationally restricted κ–opiod Receptor agonists: Synthesis and pharmacological evaluation of diastereoisomeric and enantiomeric decahydroquinoxalines
Effects of ibogaine and noribogaine on the antinociceptive action of μ-, δ-and κ–opiod Receptor agonists in mice
Dual regulation by μ, δ and κ opiod Receptor agonists of K+ conductance of DRG neurons and neuroblastoma× DRG neuron hybrid F11 cells
Decrease of κ–opiod Receptor mRNA level in ventral tegmental area of male mice after repeated experience of aggression
Effect of U50, 488H, a κ–opiod Receptor agonist on myocardial α-and β-myosin heavy chain expression and oxidative stress associated with isoproterenol-induced …
Generalization of NMDA-Receptor antagonists to the discriminative stimulus effects of κ–opiod Receptor agonists U-50,488 H, but not TRK-820 in rats
Effect of κ–opiod Receptor agonists on morphine analgesia in morphine-naive and morphine-tolerant rats
κ–opiod Receptor activation prevents against arrhythmias by preserving Cx43 protein via alleviation of intracellular calcium
κ–opiod Receptor stimulation induces arrhythmia in the isolated rat heart via the protein kinase C/Na+–H+ exchange pathway
κ–opiod Receptor agonist protects against ischemic reduction of 2-deoxyglucose uptake in morphine-tolerant rats
Endomorphin-1 Discriminates the μ-opiod Receptor From the δ-and κ–opiod Receptors by Recognizing the Difference in Multiple Regions
Efficacy and safety of a new κ–opiod Receptor agonist for the treatment of uremic pruritus
Effect of dizocilpine (MK-801) on analgesia and tolerance induced by U-50,488 H, a κ–opiod Receptor agonist, in the mouse
Effects of spiradoline mesylate, a selective κ–opiod–Receptor agonist, on the central dopamine system with relation to mouse locomotor activity and analgesia
Mechanisms involved in the hypotensive effect of a κ–opiod Receptor agonist in hypertensive rats
Promoter activity of mouse κ opiod Receptor gene in transgenic mouse
Peripheral administration of κ–opiod Receptor antagonist stimulates gonadotropin-releasing hormone pulse generator activity in ovariectomized, estrogen-treated …
Efficient synthesis of the κ–opiod Receptor agonist CJ-15,161: four stereospecific inversions at a single aziridinium stereogenic center
Induction of the mouse κ–opiod Receptor gene by retinoic acid in P19 cells
PRO‐AND ANTI‐ARRHYTHMIC EFFECTS OF A κ opiod Receptor AGONIST: A MODEL FOR THE BIPHASIC ACTION OF A LOCAL HORMONE IN THE HEART
κ opiod Receptor stimulation of [35S] GTPγS binding in guinea pig brain
Chronic U50, 488H abolishes inositol 1, 4, 5-trisphosphate and intracellular Ca2+ elevations evoked by κ–opiod Receptor in rat myocytes
… M-Substituted N-Cyclopropylmethyl-7α-phenyl-6,14-endoethanotetrahydronorthebaine as a Selective, Potent, and Orally Active κ–opiod Receptor Agonist with an …
The κ–opiod Receptor antagonist JDTic decreases ethanol intake in alcohol-preferring AA rats
Central monoaminergic mechanisms in mice and analgesic activity of spiradoline mesylate, a selective κ–opiod Receptor agonist
Prospects of using of κ–opiod Receptor agonists U-50,488 and ICI 199,441 for improving heart resistance to ischemia/reperfusion
Contralateral, ipsilateral and bilateral treatments with the κ–opiod Receptor agonist U-50,488 H in mononeuropathic rats
Diminution of contractile response by κ–opiod Receptor agonists in isolated rat ventricular cardiomyocytes is mediated via a pertussis toxin-sensitive G protein
[Pro3]Dyn A(1−11)-NH2: A Dynorphin Analogue with High Selectivity for the κ opiod Receptor
Analogs of the κ opiod Receptor antagonist arodyn cyclized by ring-closing metathesis retain κ opiod Receptor affinity, selectivity and κ opiod Receptor antagonism
N-substituted 4β-methyl-5-(3-hydroxyphenyl)-7α-amidomorphans are potent, selective κ opiod Receptor antagonists
Differential effects of μ-opiod, δ-opiod and κ–opiod Receptor agonists on dopamine Receptor agonist-induced climbing behavior in mice
Coupling of the cloned rat κ–opiod Receptor to adenylyl cyclase is dependent on Receptor expression
The amygdala mediates the impairing effect of the selective κ–opiod Receptor agonist U-50,488 on memory in CD1 mice
κ–opiod Receptor agonist inhibition of HIV-1 envelope glycoprotein-mediated membrane fusion and CXCR4 expression on CD4+ lymphocytes
Behavioral characterization of κ opiod Receptor agonist spiradoline and cannabinoid Receptor agonist CP55940 mixtures in rats
The κ–opiod Receptor agonist U50, 488H induces acute physical dependence in guinea-pigs
Antagonism of the morphine-induced Straub tail reaction by κ–opiod Receptor activation in mice
Activation of κ–opiod Receptor by U50, 488H improves vascular dysfunction in streptozotocin-induced diabetic rats
Comparative effects of selective κ–opiod Receptor agonists on dopamine levels in the dorsal caudate of freely moving rats
Modification of κ–opiod Receptor agonist-induced antinociception by diabetes in the mouse brain and spinal cord
Process research and scale-up of the κ–opiod Receptor agonist CJ-15,161 drug candidate
Participation of dorsal periaqueductal gray 5-HT1A Receptors in the panicolytic-like effect of the κ–opiod Receptor antagonist Nor-BNI
κ‐opiod Receptor‐mediated enhancement of the hyperpolarization‐activated current (Ih) through mobilization of intracellular calcium in rat nucleus raphe magnus
μ-, δ-and κ–opiod Receptor agonists do not alter the discriminative stimulus effects of cocaine or d-amphetamine in rats
κ opiod Receptor 1 single nucleotide polymorphisms were associated with the methadone dosage
Selective natural κ opiod and cannabinoid Receptor agonists with a potential role in the treatment of gastrointestinal dysfunction-Analogues of salvinorin A, an …
κ–opiod Receptor antagonism improves recovery from myocardial stunning in chronically instrumented dogs
Replacing a Palatable High-Fat Diet with a Low-Fat Alternative Heightens κ–opiod Receptor Control over Nucleus Accumbens Dopamine
Serotonergic and GABAergic neurons in the medial rostral ventral medulla express κ–opiod Receptor immunoreactivity
Combination of cyclohexane and piperazine based κ–opiod Receptor agonists: synthesis and pharmacological evaluation of trans, trans-configured …
μ-but not δ-and κ–opiod Receptor mediates the nucleus submedius interferon-α-evoked antinociception in the rat
Specific κ opiod Receptor agonists
Precipitated κ–opiod Receptor agonist withdrawal increases glutamate in rat locus coeruleus
Roles of residues 3 and 4 in cyclic tetrapeptide ligand recognition by the κ‐opiod Receptor
N-[18F]-FluoropropylJDTic for κ–opiod Receptor PET imaging: Radiosynthesis, pre-clinical evaluation, and metabolic investigation in comparison with parent JDTic
Postsynaptic and extrasynaptic localization of κ–opiod Receptor in selected brain areas of young rat and chick using an anti-Receptor monoclonal antibody
The κ–opiod Receptor antagonist nor-BNI inhibits cocaine and amphetamine, but not cannabinoid (WIN 52212-2), abstinence-induced withdrawal in planarians: An …
Role of protein kinase C‐epsilon in the development of κ‐opiod Receptor tolerance to U50, 488H in rat ventricular myocytes
OFQ reverses the κ–opiod Receptor-mediated depression of calcium current in rat dorsal root ganglion neurons
A Bivalent Ligand (KDAN-18) Containing δ-Antagonist and κ-Agonist Pharmacophores Bridges δ2 and κ1 opiod Receptor Phenotypes
p38 mitogen-activated protein kinase activation in amygdala mediates κ opiod Receptor agonist U50, 488H-induced conditioned place aversion
Synthesis and biological evaluation of 2-alkyl-2-methoxymethyl-salvinorin ethers as selective κ–opiod Receptor agonists
… Receptor Docking Simulations of 2-[(Acylamino)ethyl]-1,4-benzodiazepines as Novel Tifluadom-like Ligands with High Affinity and Selectivity for κ–opiod Receptors
The κ–opiod Receptor Agonist U-50488 Blocks Ca2+ Channels in a Voltage-and G Protein–Independent Manner in Sensory Neurons
Chemical function-based pharmacophore generation of selective κ–opiod Receptor agonists by catalyst and phase
κ‑opiod Receptor agonists may alleviate intestinal damage in cardiopulmonary bypass rats by inhibiting the NF‑κB/HIF‑1α pathway
P38: The link between the κ–opiod Receptor and dysphoria
Attenuation of the antinociceptive action of the selective κ–opiod Receptor agonist, U-50,488 H by ICS-205-930
Synthesis and biological evaluation of dibenz [b, f][1, 5] oxazocine derivatives for agonist activity at κ–opiod Receptor
Species differences in the effects of the κ–opiod Receptor antagonist zyklophin
κ‐opiod Receptor binding varies inversely with tumor grade in human gliomas
Differential effects of LY235959, a competitive antagonist of the NMDA Receptor on κ–opiod Receptor agonist induced responses in mice and rats
Activation of κ‐opiod Receptor Exerts the Glucose‐Homeostatic Effect in Streptozotocin‐Induced Diabetic Mice
Activation of κ–opiod Receptor inhibits inflammatory response induced by sodium palmitate in human umbilical vein endothelial cells
Potent inhibition of alcohol self-administration in alcohol-preferring rats by a κ–opiod Receptor antagonist
How does agonist and antagonist binding lead to different conformational ensemble equilibria of the κ–opiod Receptor: Insight from long-time gaussian accelerated …
Differential time course of effects of κ–opiod agonist treatment on dynorphin a levels and κ–opiod Receptor density
… combinations with intrathecal BRL52537 (κ–opiod agonist), pregabalin (calcium channel modulator), AF 353 (P2X3 Receptor antagonist), and A804598 (P2X7 Receptor …
κ–opiod Receptor agonists improve pirenzepine-induced disturbance of spontaneous alternation performance in the mouse
Differential antagonism of the rate-decreasing effects of κ–opiod Receptor agonists by naltrexone and norbinaltorphimine
The κ–opiod Receptor agonist asimadoline inhibits epithelial transport in mouse trachea and colon
Limbic brain structures are important sites of κ–opiod Receptor-mediated actions in the rat: a [14C]-2-deoxyglucose study
κ opiod Receptor Agonist Inhibits Myocardial Injury in Heart Failure Rats through Activating Nrf2/HO-1 Pathway and Regulating Ca2+-SERCA2a
Study of μ-and δ-opiod Activities in Agents with Various κ–Receptor Selectivity
Isolation and Chemical Modification of Clerodane Diterpenoids from Salvia Species as Potential Agonists at the κ‐opiod Receptor
Kinetic Modeling and Test–Retest Reproducibility of 11C-EKAP and 11C-FEKAP, Novel Agonist Radiotracers for PET Imaging of the κ–opiod Receptor in Humans
Syntheses of potential metabolites of a potent κ–opiod Receptor agonist, TRK-820
Pertussis and cholera toxins modulate κ–opiod Receptor agonists-induced hypothermia and gut inhibition
κ–opiod Receptor antisense oligonucleotide injected into rat hippocampus causes hypertension
Recent development and potential use of µ‐and κ‐opiod Receptor ligands in positron emission tomography studies
Reversion of muscarinic autoReceptor agonist-induced acetylcholine decrease and learning impairment by dynorphin A (1–13), an endogenous κ–opiod Receptor …
Effectiveness of nalbuphine, a κ‐opiod Receptor agonist and μ‐opiod Receptor antagonist, in the inhibition of INa, IK(M), and IK(erg) unlinked to interaction with …
κ–opiod Receptor-mediated analgesia: hotplate temperature and sex differences
κ–opiod Receptor stimulation alleviates rat vascular smooth muscle cell calcification via PFKFB3-lactate signaling
Amino acid conjugates as κ opiod Receptor agonists
Syntheses of 10-Oxo, 10α-Hydroxy, and 10β-Hydroxy Derivatives of a Potent κ–opiod Receptor Agonist, TRK-820
Involvement of κ‐opiod Receptors in peripheral response to nerve stimulation in κ‐opiod Receptor knockout mice
Focal κ–opiod Receptor-mediated dependence and withdrawal in the nucleus paragigantocellularis
Chronic κ–opiod Receptor antagonism delays the rise in blood pressure in spontaneously hypertensive rats
Differential efficacies of κ agonists to induce homologous desensitization of human κ opiod Receptor
Age-dependent effects of κ–opiod Receptor stimulation on cocaine-induced stereotyped behaviors and dopamine overflow in the caudate–putamen: an in vivo …
The function of calcineurin and ERK1/2 signal in the antihypertrophic effects of κ–opiod Receptor stimulation on myocardial hypertrophy induced by isoprenaline
κ–opiod Receptor mediated antinociception in rats is dependent on the functional state of dihydropyridine-sensitive calcium channels
N-Alkylated derivatives of [d-Pro10] dynorphin A-(1-11) are high affinity partial agonists at the cloned rat κ–opiod Receptor
Neurokinin 1 Receptor signaling mediates sex differences in μ and κ opiod-induced enhancement of contact hypersensitivity
Molecular simulation of dynorphin A-(1− 10) binding to extracellular loop 2 of the κ–opiod Receptor. A model for Receptor activation
Effects of peripheral and spinal κ–opiod Receptor stimulation on the exercise pressor reflex in decerebrate rats
κ–opiod Receptor agonist inhibits the cholera toxin-sensitive G protein in the heart
Direct detection of neuropeptide dynorphin A binding to the second extracellular loop of the κ opiod Receptor using a soluble protein scaffold
Inhibition of elevated arginine vasopressin secretion in response to osmotic stimulation and acute haemorrhage by U‐62066E, a κ‐opiod Receptor agonist
Renal responses to the κ–opiod–Receptor agonist U-50488H in conscious lambs
Tonic modulation of neurotransmitter release in the guinea-pig myenteric plexus: effect of μ and κ opiod Receptor blockade and of chronic sympathetic denervation
14-3-3ζ Protein regulates anterograde transport of the human κ–opiod Receptor (hKOPR)
κ–opiod Receptor agonist U50, 488H attenuates myocardial ischemia-reperfusionvia modulating Toll-like Receptor 4/nuclear factor-κB signaling in rat
Central antinociception induced by µ‐opiod Receptor agonist morphine, but not δ‐ or κ‐, is mediated by cannabinoid CB1 Receptor
Dynorphin A (1–8) inhibits oxidative stress and apoptosis in MCAO rats, affording neuroprotection through NMDA Receptor and κ–opiod Receptor channels
Indirect dopamine agonists augment the locomotor activating effects of the κ‐opiod Receptor agonist U‐50,488 in preweanling rats
Fentanyl combined with butorphanol protects myocardial ischemia/reperfusion injury via κ–opiod Receptor-mediated Nrf2-ARE signaling
The stereoselective κ–opiod Receptor antagonist Mr 2266 does not exhibit stereoselectivity as an antagonist at the orphan opiod (ORL1) Receptor
Role of dopamine D1 Receptors for κ–opiod–mediated locomotor activity and antinociception during the preweanling period: a study using D1 Receptor knockout mice
A cell-based, high-throughput homogeneous time-resolved fluorescence assay for the screening of potential κ–opiod Receptor agonists
Novel phenylamino acetamide derivatives as potent and selective κ opiod Receptor agonists
Dog cerebral cortex contains μ-, δ-and κ–opiod Receptors at different densities: apparent lack of evidence for subtypes of the κ–Receptor using selective radioligands
Sensitization of the adenylyl cyclase system in cloned κ–opiod Receptor-transfected cells following sustained agonist treatment: a chimeric study using G protein αi2/αq …
Response of rat globus pallidus neurons to microiontophoretically applied μ and κ opiod Receptor agonists
Ultrasonic vocalizations of preweanling rats: involvement of both α2-adrenoceptor and κ–opiod Receptor systems
Suppression of Acute Herpetic Pain-Related Responses by the κ–opiod Receptor Agonist (-)-17-Cyclopropylmethyl-3, 14β-dihydroxy-4, 5α-epoxy-6β-[N-methyl-3 …
Evidence of involvement of the nNOS and the κ–opiod Receptor in the same intracellular network of the rat periaqueductal gray that controls morphine tolerance and …
Effects of acute and repeated morphine treatment on κ–opiod Receptor protein levels in mesocorticolimbic system
The κ–opiod Receptor agonist U-69593 prevents cocaine-induced phosphorylation of DARPP-32 at Thr34 in the rat brain
Preparation and evaluation of some hydrophilic phenylacetyl-piperazines as peripherally selective κ–opiod Receptor agonists
κ‐opiod Receptor Agonists Differentially Affect the Release of Neurohypophysial Hormones
Mechanism of direct Cav2. 2 channel block by the κ–opiod Receptor agonist U50488H
Synthesis and pharmacological evaluation of conformationally restricted κ–opiod Receptor agonists
κ–opiod Receptor Agonist Ameliorates Postoperative Neurocognitive Disorder by Activating the Ca2+/CaMKII/CREB Pathway
Major effect of pyrrolic N-benzylation in norbinaltorphimine, the selective κ–opiod Receptor antagonist
Profiles of the antinociceptive effect of R-84760, a selective κ–opiod Receptor agonist, in the formalin test in mice
Effect of ICI197067, a κ–opiod Receptor agonist, spinally on Aδ and C reflexes and intracerebrally on respiration
Effect of chronic administration of U-50,488 H, a κ–opiod Receptor agonist, on central dopamine D2 Receptors of the rat
Identification of κ-and δ-opiod Receptor transcripts in immune cells
Effects of κ–opiod Receptor agonists on stimulated phosphoinositide hydrolysis in rat kidney
κ‑opiod Receptor agonist, U50488H, inhibits pyroptosis through NLRP3 via the Ca2+/CaMKII/CREB signaling pathway and improves synaptic plasticity in …
Involvement of dopamine D2 Receptor signal transduction in the discriminative stimulus effects of the κ–opiod Receptor agonist U-50,488 H in rats
Acidosis antagonizes intracellular calcium response to κ–opiod Receptor stimulation in the rat heart
Region-dependent G-protein activation by κ–opiod Receptor agonists in the mouse brain
The selective κ–opiod Receptor antagonist JDTic attenuates the alcohol deprivation effect in rats
Expression of μ-and κ-, but not δ-, opiod Receptor mRNAs is enhanced in the spinal dorsal horn of the arthritic rats
Negative modulation of spinal κ–opiod Receptor-mediated antinociception by the µ-opiod Receptor at selective doses of (−)-pentazocine
Gastric acid secretion by central injection of dynorphin A-(1–17), an endogenous ligand of κ–opiod Receptor, in urethane-anesthetized rats
Interaction of Extracellular Loop II of κ–opiod Receptor (196–228) with opiod Peptide Dynorphin in Membrane Environments as Revealed by Solid State Nuclear …
The κ–opiod Receptor agonist, U50, 488H, exerts antidystonic activity in a mutant hamster model of generalized dystonia
Design, synthesis and biological evaluation of novel tetrahydroisoquinoline quaternary derivatives as peripheral κ–opiod Receptor agonists
κ‑opiod Receptor agonist U50488H attenuates postoperative cognitive dysfunction of cardiopulmonary bypass rats through the PI3K/AKT/Nrf2/HO‑1 pathway
Stimulatory effects of centrally injected κ–opiod Receptor agonists on gastric acid secretion in urethane-anesthetized rats
Biphasic effect of a κ–opiod Receptor agonist on plasma oxytocin levels in rats
Use of Receptor chimeras to identify small molecules with high affinity for the dynorphin A binding domain of the κ opiod Receptor
κ–opiod Receptor stimulation increases the expression of Na+-H+ exchange gene in the heart
Synthesis and evaluation of κ–opiod Receptor agonistic activity and antinociceptive effect of novel morphine analogues, 7α-phenyl-6α, 14α-endo-etheno …
[125I] Dynorphin (1–8) produces a similar pattern of κ–opiod Receptor labelling to [3H] dynorphin (1–8) and [3H] etorphine in guinea pig brain: A quantitative …
Development of κ opiod Receptor agonists by focusing on phenyl substituents of 4-dimethylamino-3-phenylpiperidine derivatives: structure–activity relationship study …
Synergistic opiod inhibition of colonic Cl− secretion by κ–opiod Receptor agonism plus μ-opiod Receptor antagonism
Pharmacological Characterization of Human κ/μ opiod Receptor Chimeras that Retain High Affinity for Dynorphin A
Involvement of glutamate and γ‐amino‐butyric acid Receptor systems on gastric acid secretion induced by activation of κ‐opiod Receptors in the central nervous …
Receptor-mediated activation of G-proteins by κ opiod agonists in frog (Rana esculenta) brain membranes
Enantiomers of 2‐[(Acylamino) ethyl]‐1, 4‐benzodiazepines, Potent ligands of κ‐opiod Receptor: Chiral chromatographic resolution, configurational assignment, and …
Identification of an opiod κ Receptor Subtype-Selective N-Substituent for (+)-(3R,4R)-Dimethyl-4-(3-hydroxyphenyl)piperidine
Plasticity of signaling by spinal estrogen Receptor α, κ–opiod Receptor, and metabotropic glutamate Receptors over the rat reproductive cycle regulates spinal …
Differential effects of acute and repeated morphine treatment on κ–opiod Receptor mRNA levels in mesocorticolimbic system
Direct evidence for the up‐regulation of spinal µ‐opiod Receptor function after repeated stimulation of κ‐opiod Receptors in the mouse
Activation of c-fos mRNA in the brain by the κ–opiod Receptor agonist enadoline and the NMDA Receptor antagonist dizocilpine
κ opiod Receptor-Dynorphin Signaling in the Central Amygdala Regulates Conditioned Threat Discrimination and Anxiety
Drug–drug interactions of a novel κ–opiod Receptor agonist, nalfurafine hydrochloride, involving the P-glycoprotein
A Subtype of κ‐opiod Receptor Mediates Inhibition of High‐Affinity GTPase Inherent in Gi1 in Guinea Pig Cerebellar Membranes
Effects of κ-and μ-opiod Receptor agonists on Ca2+ channels in neuroblastoma cells: involvement of the orphan opiod Receptor
Potency enhancement of the κ–opiod Receptor antagonist probe ML140 through sulfonamide constraint utilizing a tetrahydroisoquinoline motif
κ–opiod Receptor-mediated thermonociceptive mechanisms in streptozotocin diabetes
Discovery of highly selective κ–opiod Receptor agonists: 10α-Hydroxy TRK-820 derivatives
… -[2-(1-pyrrolidinyl)-cyclohexyl] benzeneacetamide] Induces Internalization and Down-Regulation of the Human, but not the Rat, κ–opiod Receptor: Structural Basis for …
Dynorphin regulates the phagocytic activity of splenic phagocytes in wall lizards: involvement of a κ–opiod Receptor-coupled adenylate-cyclase–cAMP–PKA pathway
Nonspecific Effects of the Selective κ–opiod Receptor AgonistU-50,488 H on Dopamine Uptake and Release in PC12 Cells
Mixed κ/μ opiod Receptor agonists: the 6β-naltrexamines
Effects of R-84760, a selective κ–opiod Receptor agonist, on nociceptive reflex in isolated neonatal rat spinal cord
Enantiomerically Pure Quinoline‐Based κ‐opiod Receptor Agonists: Chemoenzymatic Synthesis and Pharmacological Evaluation
… Acid Conjugates of 2-(3,4-Dichlorophenyl)-N-methyl-N- [(1S)-1-(3-aminophenyl)-2-(1-pyrrolidinyl)ethyl]acetamide: κ opiod Receptor Agonists with Limited …
Synthesis and opiod Receptor affinity of morphinan and benzomorphan derivatives: mixed κ agonists and μ agonists/antagonists as potential pharmacotherapeutics …
Inhibitory effect of spiradoline, a κ opiod Receptor agonist, on Ca2+ induced contraction and the intracellular Ca2+ concentration in porcine coronary artery
Quantitative analysis of R-84760, a selective κ–opiod Receptor agonist, in plasma by liquid chromatography with electrospray ionization tandem mass spectrometry
Differential effects of specific δ and κ opiod Receptor antagonists on the bidirectional dose-dependent effect of systemic naloxone in arthritic rats, an experimental …
κ opiod Receptor-mediated depression of activity evoked in convergent dorsal horn cells by thermal and non-thermal noxious stimulation
… Disorder With Reduced In Vivo Norepinephrine Transporter Availability in the Locus Coeruleus” and “Association of In Vivo κ–opiod Receptor Availability and the …
Involvement of κ–opiod Receptor mechanisms in the calcitonin-induced potentiation of opiod effects at the hypothalamus-pituitary-adrenocortical axis
The NOP Receptor involvement in both withdrawal-and CCk-8-induced contracture responses of guinea pig isolated ileum after acute activation of κ–opiod Receptor
… , ∂-, and κ–opiod Receptors and Comparisons to the Neuropeptide [Tyr1]-Leu-enkephalin: Conformations, Noncovalent Amino Acid Binding Sites, Binding Energies, Electronic Factors, and Receptor …
μ-, δ-, κ-and ϵ-opiod Receptor modulation of the hypothalamic-pituitary-adrenocortical (HPA) axis: subchronic tolerance studies of endogenous opiod peptides
κ‐ and δ‐opiod Receptor functional activities are increased in the caudate putamen of cannabinoid CB1 Receptor knockout mice
Solubilization and characterization of the κ–opiod Receptor type from guinea-pig cerebellum
… Aerobic Oxidation of nor-Binaltorphimine (nor-BNI) Analogs without 4, 5-Epoxy Bridge Affords a More Selective Ligand for κ opiod Receptor than the Representative …
A novel series of potent and selective agonists at the opiod κ–Receptor
Modification of the binding of [3H] MK-801 to brain regions and spinal cord of rats treated chronically with U-50,488 H, a κ–opiod Receptor agonist
Influence of temperature on the effects of μ-, δ-and κ–opiod Receptor agonists in the guinea-pig ileum myenteric plexus
κ–opiod Receptor recognition sites are not modulated by local anaesthetics
Comparative Analysis of Infarct Size Limiting Activity of κ–opiod Receptor Agonists in In Vivo Reperfused Heart
Comparison of the in vitro efficacy of μ, δ, κ and ORL1 Receptor agonists and non-selective opiod agonists in dog brain membranes
Induction of bladder sphincter dyssynergia by κ-2 opiod Receptor agonists in the female rat
Species variation in effects of intrathecal κ–opiod Receptor agonist on morphine-induced itch and antinociception
Lack of effect of κ–opiod Receptor agonism on long-term methamphetamine-induced neurotoxicity in rats
Inhibitory effects of κ–opiod Receptor stimulation on ne-induced cardiac hypertrophy of the cultured myocardial cells
[Biocytin13] Dynorphin A 1-13 Amide: A Potential Probe for the κ–opiod Receptor
Antagonism of phosphoramidon-induced antinociception in mice by μ-but not κ–opiod Receptor blockers
An examination of the cardiac actions of PD117, 302, a κ–opiod Receptor agonist
The role of κ–opiod Receptor-induced autophagy in synaptic alterations
κ and δ-opiod Receptor agonists differentially inhibit striatal dopamine and acetylcholine release
Peptidomimetics of the κ–opiod Receptor. A hybrid MPCB/peptide ligand (MPCB-RRI) binds κ cloned Receptor with nanomolar affinity
dextro-and levo-morphine attenuate opiod δ and κ Receptor agonist produced analgesia in μ-opiod Receptor knockout mice
Mixed κ agonists and μ agonists/antagonists as potential pharmacotherapeutics for cocaine abuse: synthesis and opiod Receptor binding affinity of N-substituted …
Design and synthesis of 10-oxo derivative of N-cyclopropylmethyl (−)-6β-acetylthiodihydro-normorphine, a potentially κ-selective opiod Receptor ligand
Serotonergic mechanisms involved in calcitonin potentiation of κ–opiod Receptor-mediated effects on adrenal secretion
Role of κ–opiod Receptor agonist U-50,488 H in consummatory successive negative contrast
Paradoxical locomotor activating effects of κ–opiod Receptor stimulation in the preweanling rat:: Role of the ventromedial thalamus and superior colliculus
The Region in the μ opiod Receptor Conferring Selectivity for Sufentanil over the δ Receptor is Different from that over the κ Receptor
KATP channels mediate the antihypertrophic effects afforded by κ–opiod Receptor stimulation in neonatal rat ventricular myocytes
Structural analysis of κ‐opiod Receptor agonists
Synthesis of [3H]DIPPA: A potent irreversible antagonist selective for the κ opiod Receptor
Antiarrhythmic effect of κ–opiod on Cx43 in rat heart during mycardial ischemia and reperfusion via inhibiting β-adrenergic Receptor pathway
Computational insights into different inhibition modes of the κ–opiod Receptor with antagonists LY2456302 and JDTic
… and peripheral modification of 1-(pyrrolidin-1-ylmethyl)-2-[(6-chloro-3-oxo-indan)-formyl]-1, 2, 3, 4-tetrahydroisoquinolines as novel selective κ opiod Receptor …
Effects of naloxone, morphine and κ–opiod Receptor agonists on hypoxia/hypoglycemia-induced reduction of 2-deoxyglucose uptake in hippocampal slices from U …
… effect of [(±)-(2, 4, 6-cis)-4-chloro-6-(naphthalen-1-yl)-tetrahydro-2H-pyran-2-yl] methanol: participation of the NO/cGMP/KATP pathway and κ–opiod Receptor
Modulation of κ–opiod Receptor mediated tolerance in the guinea-pig ileum by chronic co-administration of dihydropyridines
The antinociceptive activity of κ-but not δ-opiod Receptor agonists is maintained in morphine-tolerant neuropathic rats
Interaction of the adenosine A1 Receptor agonist N6-cyclopentyladenosine and κ–opiod Receptors in rat spinal cord nociceptive reflexes
Amphetamine-induced preprodynorphin mRNA expression and κ–opiod Receptor binding in basal ganglia of adult rats after prenatal exposure to diazepam
Selective depression of dorsal root-evoked high threshold synaptic excitation by the selective κ opiod Receptor agonist enadoline in the neonatal rat hemisected …
Spinal synthesis of estrogen and concomitant signaling by membrane estrogen Receptors regulate spinal κ-and μ-opiod Receptor heterodimerization and female …
The opiod Receptor subtypes μ and κ, but not δ, are involved in the control of the vasopressin and oxytocin release in the rat
Comparison of the Effects of a Series of κ–opiod Receptor Agonists Upon Sodium Channel Function in Rat Brain Miniprisms
opiod antagonists and drinking: evidence of κ–Receptor involvement
Developmental expression of the μ, κ, and δ opiod Receptor mRNAs in mouse
δ antagonist and κ agonist activity of naltriben: Evidence for differential κ interaction with the δ1 and δ2 opiod Receptor subtypes
κ–opiod Receptor is involved in electroacupuncture analgesia via inhibition of spinal microglial Toll-like Receptor 4 in neuropathic pain rats
Angiotensin II induced myocardial hypertrophy in neonatal rats could be attenuated by activated κ–opiod Receptor via modulating the calcineurin signal pathways
Enhancement of a κ–opiod Receptor agonist-induced analgesia by L-tyrosine and L-tryptophan
Effects of the κ‑opiod Receptor on the inhibition of 100 Hz electroacupuncture on cocaine‑induced conditioned place preference
Stereoselective Synthesis and Pharmacological Evaluation of 2, 4-Bridged Piperidine Derivatives Designed to Activate the κ–opiod Receptor
Conversion of δ-, κ-and μ-Receptor Selective opiod Peptide Agonists into δ-, κ-and μ-Selective Antagonists
Discovery of an opiod κ Receptor selective pure antagonist from a library of N-substituted 4β-methyl-5-(3-hydroxyphenyl) morphans
Identification of the First trans-(3R,4R)- Dimethyl-4-(3-hydroxyphenyl)piperidine Derivative To Possess Highly Potent and Selective opiod κ Receptor Antagonist …
opiod μ-and κ–Receptor mediate phospholipase C activation through Gi1 in Xenopus oocytes
Synthesis and opiod Receptor binding affinities of 2-substituted and 3-aminomorphinans: Ligands for μ, κ, and δ opiod Receptors
A DFT Analysis of the Relationships between Electronic Structure and Human κ, δ and μ opiod Receptor Binding Affinity in a series of Diphenethylamines
The opiod Receptor like-1 Receptor agonist Ro 64-6198 (1S, 3aS-8-2, 3, 3a, 4, 5, 6-hexahydro-1H-phenalen-1-yl-1-phenyl-1, 3, 8-triaza-spiro [4.5] decan-4-one) …
Synthesis and Characterisation of 𝜅 opiod Receptor (KOR) Antagonists
Antipruritic Activity of a Novel κ–opiod Receptor Agonist
… S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)- 3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro- 3-isoquinolinecarboxamide as a Novel Potent and Selective opiod κ Receptor …
Novel κ–opiod Receptor Antagonists Derived from Salvinorin A
Remifentanil post‐conditioning attenuates cardiac ischemia–reperfusion injury via κ or δ opiod Receptor activation
Cloning and pharmacological characterization of a rat κ opiod Receptor
Essential structure of opiod κ Receptor agonist nalfurafine for binding to κ Receptor 1: synthesis of decahydroisoquinoline derivatives and their pharmacologies
STUDY OF κ–opiod Receptor EXPRESSION IN CELL CULTURES AND IN HUMAN BRAIN
κ‐opiod Receptor Activation Induces the Autophagic Machinery and Alters Dendritic Spine Density
The efficacy of Dynorphin fragments at the κ, μ and δ opiod Receptor in transfected HEK cells and in an animal model of unilateral peripheral inflammation
Studies of μ-, κ-, and δ-opiod Receptor density and G protein activation in the cortex and thalamus of monkeys
Effect of Niravoline (RU51599), a κ–opiod Receptor Agonist, on Tumour-Origin Brain Oedema
Role of activation of κ–opiod Receptor in inhibiting myocardial ischemia reperfusion injury in mice
Inhibition of Human CaV2. 3 Channels via μ-, δ-and κ–opiod Receptor Activation
Chemical neuroanatomical and psychopharmacological evidence that κ Receptor-mediated endogenous opiod peptide neurotransmission in the dorsal and …
New thoughts in mechanism research of acupuncture for myocardial stunning from κ–opiod Receptor signaling pathway
κ–opiod Receptor signals through Src and focal adhesion kinase to
It takes more than one κ opiod Receptor to inhibit a POMC neuron
Prospects for a Novel κ–opiod Receptor Agonist, TRK-820
Do activators of the κ–opiod Receptor hold the potential for anti-arrhythmic drug development?
Differential modulation of κ and μ opiod antinociception by the glycine/NMDA Receptor agonist D‐serine
Differential inhibitory/stimulatory modulation of spinal CCK release by μ and δ opiod agonists, and selective blockade of μ-dependent inhibition by κ Receptor …
Modulation of Renal Excretory Function by the Conformationally Restricted Enantiomeric κ‐opiod Receptor Agonists:(+) U‐50,488 and (−) U‐50,488
Efficacy of acting κ opiod Receptor for prevention of high altitude pulmonary edema in rats
Selective interference of β-arrestin 1 with κ and δ but not μ opiod Receptor/G protein coupling
Discovery and biological evaluation of a diphenethylamine derivative (HS665), a highly potent and selective κ opiod Receptor agonist
Stilbenes as κ-selective, non-nitrogenous opiod Receptor antagonists
κ–opiod Receptor activation promotes mitochondrial fusion and enhances myocardial resistance to ischemia and reperfusion injury via STAT3-OPA1 pathway
In silico results of κ–opiod Receptor antagonists as ligands for the second bromodomain of the Pleckstrin Homology Domain Interacting Protein
Study on mechanisms of κ–opiod Receptor agonist affects neonatal rat myocardial hypertrophy induced by isoproterenol
Structure of a κ–opiod Receptor misfit:(1S, 5R, 8R, 9R)-2′-hydroxy-5, 9-dimethyl-8, 2-epoxyethano-6, 7-benzomorphan hydrochloride
The κ–opiod Receptor antagonist nor-binaltorphimine (nor-BNI) facilitates the development of morphine-induced behavioral sensitization
Role of the Activation of Spinal κ–opiod Receptor in the Development of Spinal Centralization Induced by Remifentanil After Incision in Rats
The Effects of κ–opiod Receptor Stimulation on Electrical Coupling during Ischemia in the Perfused Isolated Rat Heart
2P078 Interactions between Dynorpin and Extra Celler Loop II of κ–opiod Receptor as studied by Solid State NMR (30. Protein function (II), Poster Session, Abstract …
Protective effect of κ–opiod Receptor agonist U50, 488 H pretreatment by intrathecal injection on myocardial ischemia/reperfusion injury
The Widely Available Hallucinogenic Plant Salvia divinorum and Its Main Component, Salvinorin A: A Unique κ–opiod Receptor (KOP-r) Agonist with Powerful …
Chronic U50, 488H abolishes inositol 1, 4, 5-trisphosphate and intracellular Ca 2+ elevations evoked by κ–opiod Receptor in rat myocytes
Chronic Stress and Extended Access to Cocaine Produce Increased Drug Intake: Involvement of κ–opiod Receptor Activation
Down-regulation of Spinal κ–opiod Receptor Involved in Spinal Centralization Induced by Remifentanil After Incision in Rats
Agonists Specific for κ–opiod Receptor Induces Apoptosis of HCC Cells Through Enhanced Endoplasmic Reticulum Stress
κ opiod Receptor Stimulation of [35S] GTPγS Binding in Guinea Pig Brain – Interaction with multiple G-proteins is not specific for any individual Gα subunit and is …
Genome Mining-Based Discovery of Blenny Fish-Derived Peptides Targeting the Mouse κ–opiod Receptor
β-adrenergic response modulated by κ–opiod Receptor stimulation is attenuated in the cardiomyocytes of rats following chronic hypoxia
1P103 Interaction of ECL-II of κ–opiod Receptor with dynorphin in membrane environments as revealed by solid state NMR, QCM and MD simulation (03. Membrane …
Correction: In the article “κ–opiod Receptor Agonists Modulate Visceral Nociception at a Novel, Peripheral Site of Action,” by SK Joshi, Xin Su, Frank Porreca, and GF …
3P-174 Interaction of opiod peptide dynorphin with extracellular loop 2 of κ–opiod Receptor as studied by^< 13> C NMR (Biol & Artifi memb.: Structure & Property, The …
… and ethanol concentrations in the nucleus accumbens during the development of reinforcement and the involvement of the κ–opiod Receptor in the modulation …
Novel 3, 4, 7-Substituted Benzofuran Derivatives Having Binding Affinity to κ–opiod Receptor
DIPPA: An opiod Receptor affinity label that produces selective and long-lasting κ antagonism in mice

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