CROSS LINK BREAKERS
December 8, 2023GLIFLOZINS
December 8, 2023
- FNDC5/irisin is not only a myokine but also an adipokine
- Irisin/FNDC5-An updated review
- Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway
- Irisin and FNDC5 in retrospect: an exercise hormone or a transmembrane receptor?
- Are skeletal muscle FNDC5 gene expression and irisin release regulated by exercise and related to health?
- Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models
- FNDC5 alleviates oxidative stress and cardiomyocyte apoptosis in doxorubicin-induced cardiotoxicity via activating AKT
- FNDC5: a novel player in metabolism and metabolic syndrome
- Fndc5 knockdown significantly decreased neural differentiation rate of mouse embryonic stem cells
- Effects of obesity, diabetes and exercise on Fndc5 gene expression and irisin release in human skeletal muscle and adipose tissue: in vivo and in vitro studies
- New insights into the cellular activities of Fndc5/Irisin and its signaling pathways
- Expression of the irisin precursor FNDC5 in skeletal muscle correlates with aerobic exercise performance in patients with heart failure
- Elevated skeletal muscle irisin precursor FNDC5 mRNA in obese OLETF rats
- FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to …
- A role for FNDC5/Irisin in the beneficial effects of exercise on the brain and in neurodegenerative diseases
- Increased FNDC5/Irisin expression in human hepatocellular carcinoma
- Does PGC1α/FNDC5/BDNF elicit the beneficial effects of exercise on neurodegenerative disorders?
- Myostatin knockout drives browning of white adipose tissue through activating the AMPK‐PGC1α‐Fndc5 pathway in muscle
- FNDC5/Irisin inhibits pathological cardiac hypertrophy
- Fndc5 overexpression facilitated neural differentiation of mouse embryonic stem cells
- FNDC5/Irisin–their role in the nervous system and as a mediator for beneficial effects of exercise on the brain
- FNDC5 overexpression and irisin ameliorate glucose/lipid metabolic derangements and enhance lipolysis in obesity
- Hepatic FNDC5 is a potential local protective factor against Non-Alcoholic Fatty Liver
- Exercise training does not increase muscle FNDC5 protein or mRNA expression in pigs
- FNDC5 alleviates hepatosteatosis by restoring AMPK/mTOR-mediated autophagy, fatty acid oxidation, and lipogenesis in mice
- FNDC5 is produced in the stomach and associated to body composition
- Irisin and FNDC5: effects of 12-week strength training, and relations to muscle phenotype and body mass composition in untrained women
- FNDC5 attenuates adipose tissue inflammation and insulin resistance via AMPK-mediated macrophage polarization in obesity
- A polymorphism in the Irisin-encoding gene (FNDC5) associates with hepatic steatosis by differential miRNA binding to the 3′ UTR
- The diagnostic value of FNDC5/irisin in renal cell cancer
- Progress and challenges in the biology of FNDC5 and irisin
- Glucocorticoid receptor positively regulates transcription of FNDC5 in the liver
- Can resistance exercise alter irisin levels and expression profiles of FNDC5 and UCP1 in rats?
- FNDC5 expression and circulating irisin levels are modified by diet and hormonal conditions in hypothalamus, adipose tissue and muscle
- Common Genetic Variation in the Human FNDC5 Locus, Encoding the Novel Muscle-Derived ‘Browning’ Factor Irisin, Determines Insulin Sensitivity
- FNDC5 attenuates obesity-induced cardiac hypertrophy by inactivating JAK2/STAT3-associated inflammation and oxidative stress
- Association of metabolic parameters and rs726344 in FNDC5 with serum irisin concentrations
- Effects of swimming exercise on serum Irisin and bone FNDC5 in rat models of high-fat diet-induced osteoporosis
- SMAD3 negatively regulates serum irisin and skeletal muscle FNDC5 and peroxisome proliferator-activated receptor γ coactivator 1-α (PGC-1α) during …
- Exercise-induced myokine FNDC5/irisin functions in cardiovascular protection and intracerebral retrieval of synaptic plasticity
- Combined training, FNDC5/irisin levels and metabolic markers in obese men: A randomised controlled trial
- Lack of adipocyte-fndc5/irisin expression and secretion reduces thermogenesis and enhances adipogenesis
- Myostatin signals through miR-34a to regulate Fndc5 expression and browning of white adipocytes
- FNDC5 promotes paclitaxel sensitivity of non-small cell lung cancers via inhibiting MDR1
- Induced expression of Fndc5 significantly increased cardiomyocyte differentiation rate of mouse embryonic stem cells
- Time-dependent changes in increased levels of plasma irisin and muscle PGC-1α and FNDC5 after exercise in mice
- FNDC5/irisin, a molecular target for boosting reward-related learning and motivation
- Greek goddess or Greek myth: the effects of exercise on irisin/FNDC5 in humans
- FNDC5 attenuates oxidative stress and NLRP3 inflammasome activation in vascular smooth muscle cells via activating the AMPK-SIRT1 signal pathway
- Fndc5 loss‐of‐function attenuates exercise‐induced browning of white adipose tissue in mice
- Obese with higher FNDC5/Irisin levels have a better metabolic profile, lower lipopolysaccharide levels and type 2 diabetes risk
- Expression of Irisin/FNDC5 in cancer cells and stromal fibroblasts of non-small cell lung cancer
- Locus characterization and gene expression of bovine FNDC5: is the myokine irisin relevant in cattle?
- FNDC5 polymorphism influences the association between sarcopenia and liver fibrosis in adults with biopsy-proven non-alcoholic fatty liver disease
- Grape pomace extract supplementation activates FNDC5/irisin in muscle and promotes white adipose browning in rats fed a high-fat diet
- Effects of physical activity on the link between PGC-1a and FNDC5 in muscle, circulating Ιrisin and UCP1 of white adipocytes in humans: A systematic review
- FNDC5/Irisin: a new protagonist in acute brain injury
- Icariin induces irisin/FNDC5 expression in C2C12 cells via the AMPK pathway
- Exercise-mimicking treatment fails to increase Fndc5 mRNA & irisin secretion in primary human myotubes
- FNDC5 inhibits foam cell formation and monocyte adhesion in vascular smooth muscle cells via suppressing NFκB-mediated NLRP3 upregulation
- Common single nucleotide polymorphisms in the FNDC5 gene are associated with glucose metabolism but do not affect serum irisin levels in Japanese men with low …
- Gene location, expression, and function of FNDC5 in Meishan pigs
- A comparative study on the effects of high-fat diet and endurance training on the PGC-1α-FNDC5/irisin pathway in obese and nonobese male C57BL/6 mice
- FNDC5/irisin improves the therapeutic efficacy of bone marrow-derived mesenchymal stem cells for myocardial infarction
- The saturated fatty acid palmitate induces insulin resistance through Smad3-mediated down-regulation of FNDC5 in myotubes
- FNDC5/Irisin attenuates diabetic cardiomyopathy in a type 2 diabetes mouse model by activation of integrin αV/β5-AKT signaling and reduction of oxidative/nitrosative …
- PGC-1α–FNDC5–BDNF signaling pathway in skeletal muscle confers resilience to stress in mice subjected to chronic social defeat
- Exercise training protects against aging-induced cognitive dysfunction via activation of the hippocampal PGC-1α/FNDC5/BDNF pathway
- Protective actions of exercise‐related FNDC5/Irisin in memory and Alzheimer’s disease
- FNDC5/Irisin System in Neuroinflammation and Neurodegenerative Diseases: Update and Novel Perspective
- An Interaction between a FNDC5 Variant and Obesity Modulates Glucose Metabolism in a Chinese Han Population
- … treadmill exercise ameliorates amyloid-β-induced learning and memory impairment, possibly via increasing AMPK activity and up-regulation of the PGC-1α/FNDC5 …
- Associations of circulating irisin with FNDC5 expression in fat and muscle in type 1 and type 2 diabetic mice
- Serum and adipose tissue mRNA levels of ATF3 and FNDC5/irisin in colorectal cancer patients with or without obesity
- Upregulation of FNDC5 gene expression in C2C12 cells after single and combined treatments of resveratrol and ATRA
- SNPs in FNDC5 (irisin) are associated with obesity and modulation of glucose and lipid metabolism in Saudi subjects
- Skeletal muscle AMPK is essential for the maintenance of FNDC5 expression
- miR-137 restricts the viability and migration of HTR-8/SVneo cells by downregulating FNDC5 in gestational diabetes mellitus
- Exercise enhances mitochondrial fission and mitophagy to improve myopathy following critical limb ischemia in elderly mice via the PGC1a/FNDC5/irisin …
- Obesity caused by a high-fat diet regulates the Sirt1/PGC-1α/FNDC5/BDNF pathway to exacerbate isoflurane-induced postoperative cognitive dysfunction in older …
- Effect of exercise training on the FNDC5/BDNF pathway in spontaneously hypertensive rats
- Standardization of exercise intensity and consideration of a dose–response is essential. Commentary on “Exercise-linked FNDC5/irisin rescues synaptic …
- Maternal and neonatal irisin precursor gene FNDC5 polymorphism is associated with preterm birth
- Effects of dietary macronutrient composition on FNDC5 and irisin in mice skeletal muscle
- Molecular identification of FNDC5 and effect of irisin on the glucose metabolism in common carp (Cyprinus carpio L.)
- FNDC5 relates to skeletal muscle IGF-I and mitochondrial function and gene expression in obese men with reduced growth hormone
- Epistasis, physical capacity-related genes and exceptional longevity: FNDC5 gene interactions with candidate genes FOXOA3 and APOE
- Circulating irisin levels and muscle FNDC5 mRNA expression are independent of IL-15 levels in mice
- … study on the effects of acute and chronic downhill running vs uphill running exercise on the RNA levels of the skeletal muscles PGC1-α, FNDC5 and the adipose …
- Antidepressant-like and pro-neurogenic effects of physical exercise: The putative role of FNDC5/irisin pathway
- PGC-1α or FNDC5 is involved in modulating the effects of Aβ1− 42 oligomers on suppressing the expression of BDNF, a beneficial factor for inhibiting …
- FNDC5 expression in Purkinje neurons of adult male rats with acute spinal cord injury following treatment with methylprednisolone
- Effects of concurrent training on irisin and fibronectin type-III domain containing 5 (FNDC5) expression in visceral adipose tissue in type-2 diabetic rats
- RNA/protein discordant expression of Fndc5 in central nervous system is likely to be mediated through microRNAs
- Irisin-encoding gene (FNDC5) variant is associated with changes in blood pressure and lipid profile in type 2 diabetic women but not in men
- Cleavage of FNDC5 and insights into its maturation process
- … of irisin injections on feeding behavior and expression of appetite regulators, uncoupling proteins and lipoprotein lipase, and fasting-induced changes in FNDC5 …
- Physical exercise stimulates hippocampal mTORC1 and FNDC5/irisin signaling pathway in mice: Possible implication for its antidepressant effect
- Enhanced expression of FNDC5 in human embryonic stem cell-derived neural cells along with relevant embryonic neural tissues
- Fndc5 knockdown induced suppression of mitochondrial integrity and significantly decreased cardiac differentiation of mouse embryonic stem cells
- Curcumin improves insulin sensitivity and increases energy expenditure in high-fat-diet–induced obese mice associated with activation of FNDC5/irisin
- … exercise alleviates oxidative stress-induced apoptosis in kidneys of myocardial infarction mice by inhibiting ALCAT1 and activating FNDC5/Irisin signaling pathway
- NAD+-boosting therapy alleviates nonalcoholic fatty liver disease via stimulating a novel exerkine Fndc5/irisin
- Association of irisin and FNDC5 rs16835198 G> T gene polymorphism with type 2 diabetes mellitus and diabetic nephropathy. An Egyptian pilot study
- The Role of FNDC5/Irisin in the Nervous System and as a Mediator for Beneficial Effects of Exercise on the Brain
- Assessment of PGC1α-FNDC5 axis in granulosa cells of PCOS mouse model
- FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in …
- Effect of sleeve gastrectomy on the expression of meteorin-like (METRNL) and Irisin (FNDC5) in muscle and brown adipose tissue and its impact on uncoupling …
- The Effect of Vitamin D Supplementation on Serum and Muscle Irisin Levels, and FNDC5 Expression in Diabetic Rats
- Irisin/FNDC5: A participant in camel metabolism
- Characterization of fibronectin type III domain-containing protein 5 (FNDC5) gene in chickens: Cloning, tissue expression, and regulation of its expression in the …
- Cardiac differentiation of mouse embryonic stem cells is influenced by a PPAR γ/PGC-1α—FNDC5 pathway during the stage of cardiac precursor cell formation
- PPARγ/Pgc-1α-Fndc5 pathway up-regulation in gastrocnemius and heart muscle of exercised, branched chain amino acid diet fed mice
- Impacts of rat hindlimb Fndc5/irisin overexpression on muscle and adipose tissue metabolism
- Effect of Acute Resistance Training on Plasma Irisin Protein Level and Expression of Muscle FNDC5 and Adipose Tissue UCP1 Genes in Male Rats.
- Obesity and its association with irisin level among individuals with FNDC5/Irisin gene variants RS16835198 and RS726344
- Identification, Cloning, and Functional Analysis of the TATA-Less Mouse FNDC5 Promoter During Neural Differentiation
- Impact of a single bout of high-intensity interval exercise and short-term interval training on interleukin-6, FNDC5, and METRNL mRNA expression in human …
- Circular RNA AFF4 modulates osteogenic differentiation in BM-MSCs by activating SMAD1/5 pathway through miR-135a-5p/FNDC5/Irisin axis
- The effectiveness of continuous and interval exercise preconditioning against chronic unpredictable stress: Involvement of hippocampal PGC-1α/FNDC5/BDNF …
- FNDC4 and FNDC5 reduce SARS-CoV-2 entry points and spike glycoprotein S1-induced pyroptosis, apoptosis, and necroptosis in human adipocytes
- FNDC5/Irisin counteracts lipotoxic-induced apoptosis in hypoxic H9c2 cells
- FNDC5/irisin is expressed and regulated differently in human periodontal ligament cells, dental pulp stem cells and osteoblasts
- Exosomes secreted by FNDC5-BMMSCs protect myocardial infarction by anti-inflammation and macrophage polarization via NF-κB signaling pathway and …
- Auricular acupuncture induces FNDC5/irisin and attenuates obese inflammation in mice
- Cardiorespiratory Fitness and Muscular Strength Moderates the Relationship between FNDC5 Polymorphism and Adiposity in Children and Adolescents
- Extracellular vesicle-mediated miR135a-5p transfer in hypertensive rat contributes to vascular smooth muscle cell proliferation via targeting FNDC5
- The effects of resistance and endurance training on the liver tissue FNDC5 mRNA gene expression in male rats
- FNDC5 (irisin) gene and exceptional longevity: a functional replication study with rs16835198 and rs726344 SNPs
- Role of swimming on muscle PGC-1α, FNDC5 mRNA, and assessment of serum omentin, adropin, and irisin in high carbohydrate high fat (HCHF) diet …
- Increased FNDC5/IRISIN protein expression in breast cancer tissue is associated with obesity in postmenopausal women
- Subchronic administration of creatine produces antidepressant-like effect by modulating hippocampal signaling pathway mediated by FNDC5/BDNF/Akt in mice
- Dietary intervention, when not associated with exercise, upregulates irisin/FNDC5 while reducing visceral adiposity markers in obese rats
- Music-Based Intervention Ameliorates mMecp2-Loss-Mediated Sociability Repression in Mice through the Prefrontal Cortex FNDC5/BDNF Pathway
- The Acute Effects of Swimming Exercise on PGC-1α-FNDC5/Irisin-UCP1 Expression in Male C57BL/6J Mice
- Ameliorative effects of garlic oil on FNDC5 and irisin sensitivity in liver of streptozotocin-induced diabetic rats
- Association between FNDC5 genetic variants and proliferative diabetic retinopathy in a Chinese population
- Eight Weeks of High-Intensity Interval Static Strength Training Improves Skeletal Muscle Atrophy and Motor Function in Aged Rats via the PGC-1α/FNDC5 …
- Exercise Training Enhances Myocardial Mitophagy and Improves Cardiac Function via Irisin/FNDC5-PINK1/Parkin Pathway in MI Mice
- ERK1/2 is a key regulator of Fndc5 and PGC1α expression during neural differentiation of mESCs
- Effect of Different Exercise Mode and Ur-solic Acid Supplementation on FNDC5 and UCP1 Gene Expression and Plasma Irisin in Rats
- The effects of MiR-214-3p and Irisin/FNDC5 on the biological behavior of osteosarcoma cells
- miR-31-5p Promotes Oxidative Stress and Vascular Smooth Muscle Cell Migration in Spontaneously Hypertensive Rats via Inhibiting FNDC5 Expression
- Fndc5 knockdown significantly decreased the expression of neurotrophins and their respective receptors during neural differentiation of mouse embryonic stem cells
- Common single nucleotide polymorphisms in the FNDC5 gene and serum irisin levels in acute myocardial infarction
- The data on the aerobic training with or without calorie restriction and muscular levels of Irisin and muscular FNDC5 concentration in obese male Wistar rats
- FNDC5 expression closely correlates with muscle fiber types in porcine longissimus dorsi muscle and regulates myosin heavy chains (MyHCs) mRNA …
- Effects of myostatin deficiency on PGC-1α and FNDC5 expression in three different murine muscle types
- Effect of Training on PPARGC1A and FNDC5 Gene Expression in Thoroughbred Horses
- Aerobic exercise modulates noncoding RNA network upstream of FNDC5 in the Gastrocnemius muscle of high-fat-diet-induced obese mice
- Are Heart Muscle Irisin Levels and FNDC5 Gene Expression Regulated by Endurance and Resistance Exercises?
- The Effect of Short Endurance Training on PGC-1α/FNDC5/BDNF Signalling Pathway In 6-OHDA-Induced Parkinson’s Rats
- Associations of Circulating Irisin with FNDC5 Expression in Fat and Muscle in Type 1 and Type 2 Diabetic Mice. Biomolecules 2021, 11, 322
- Diagnostic value of FNDC5 in patients with subclinical diabetic cardiomyopathy
- Effect of 8 weeks resistance training on plasma irisin protein level and muscle FNDC5 and adipose tissue UCP1 genes expression in male rats
- Cystathionine γ-lyase-hydrogen sulfide (H2S) deficiency downregulates muscle myokine Fndc5/Irisin and glucose metabolism in C2C12 myotubes and gastrocnemius …
- Research update on the effect of irisin/FNDC5 on metabolism of children and adolescents
- Evaluation of Serum Concentration of the Myokine Irisin (FNDC5) in Patients with Age-Related Macular Degeneration
- Lentiviral vector overexpressing FNDC5 inhibits proliferation and migration of smooth muscle cells
- Curcumin relieves CUMS-induced depressive-like behaviors through PGC-1α/FNDC5/BDNF pathway
- The Effects of a High Fat Diet and Exercise on the PGC-1alpha-FNDC5/irisin Pathway in C57BL/6 Mice
- Effect of Adipose Tissue-Derived Stem Cell Transplantation and Six Weeks of Aerobic Exercise on FNDC5 and Irisin Levels in Streptozotocin-Induced …
- FNDC5 gene expression in the smooth muscles of dromedary camels (Camelus dromedarius).
- Irisin Precursor FNDC5 and Glycemic Control in Patients With Type 2 Diabetes
- Effect of muscle exercise on metabolic disturbance induced by ovariectomy alone or with diabetes mellitus in rats; targeting the role of PGC-1α and FNDC5 expression
- The effect of progressive resistance and endurance training on gastrocnemius muscle’s FNDC5 gene expression in male rats
- Expression of FNDC5 in liver cancer tissues and its relationship with clinical parameters
- The effect of the treadmill running on genes expression ofthePGC-1α, FNDC5 and BDNF in hippocampus of male rats
- The Effect of Endurance Training and High-Fat Diet on PGC-1a/FNDC5/Irisin Pathway in Male C57BL/6 Mice
- Common single nucleotide polymorphisms in the FNDC5 gene and serum irisin levels in acute myocardial infarction
- STUDY OF FNDC5 GENE POLYMORPHISM Rs3480 AND RS16835198 WITH OBESE PATIENTS AND SPORT INDIVIDUAL IN IRAQI POPULATIONS
- Irisin and FNDC5 Responses to Exercise in Different Environmental Conditions
- Expression of FNDC5/Irisin in pancreatic cancer and its relationship with clinicopathological features
- miR-377 inhibition enhances the survival of trophoblast cells via upregulation of FNDC5 in gestational diabetes mellitus
- FNDC5 expression in skeletal muscle in chronic heart failure: relevance of inflammatory cytokines (704.1)
- Icariin Improves Lipid Metabolism via PGC1-α/FNDC5/UCP1 Pathway
- MON-289 Urokinase-type Plasminogen Activator May be Linked to FNDC5 Expression during Exercise
- Comparing the Effect of Aerobic Exercise with Different Intensities on FNDC5 Protein Level of Muscle Tissue in Obese Wistar Rats
- … Effect of High Intensity Interval Training with Vitamin E Consumption on Serum Levels of Irisin and Gene Expression of Membrane Protein FNDC5 of Soleus Muscle in …
- P-74: Effect of Fndc5 Overexpression onCardiac Differentiation Rate of mESCs
- FNDC5 rs3480 A> G polymorphism disentangles steatosis from fibrosis severity in patients with nonalcoholic fatty liver disease
- PO-242 Effects of tail suspension on the expression of FNDC5/Irisin protein in rat skeletal muscle
- Increased FNDC5 (irisin) expression in subcutaneous adipose tissue in obese patients with type 2 diabetes 1 year after bariatric surgery
- Exercise‐linked FNDC5/Irisin attenuates macrophage‐mediated renal inflammation in type 1 diabetes in aged mice
- CONSTRUCTION OF A LENTI-X-ADVANCED INDUCIBLE SYSTEM CARRYING FIBRONECTIN TYPE III DOMAIN CONTAINING5 PROTEIN (FNDC5) CODING …
- Different intensities of endurance training affect serum Irisin level and skeletal muscle protein expression of PGC-1alpha, FNDC5, and PPARdelta in mice with obesity …
- Eight-week Climbing Ladder Exercise with Load Induces Differential Expression of PGC1α/FNDC5/MSTN in Soleus and Extensor Digitorum Longus Muscle in SD …
- Assessment of The Possibility of ERK1/2 Effect on Fndc5 Expression during Neural Differentiation of Mouse Embryonic Stem Cells.
- The rs1746661 polymorphism in the FNDC5 (Irisin) gene is associated with increased levels of total cholesterol in white patients with type 2 diabetes mellitus
- MPS 07-03 EFFECT OF EXERCISE TRAINING ON FNDC5/BDNF PATHWAY IN THE HEART POST MYOCARDIAL INFARCTION
- Construction of Recombinant Lentiviral Vector Containing shRNA against Mouse Fndc5 Gene in Order to Transduce Mouse Embryonic Stem Cells
- Effects of cardiorespiratory fitness, acute aerobic exercise and common single nucleotide polymorphisms in FNDC5 gene on serum irisin levels and glucose …
- THE EFFECTS OF RECOMBINANT FNDC5 PEPTIDE ADDITION TO MOUSE EMBRYONIC STEM CELL CULTURE ON EXPRESSION OF THREE GERM LAYER …
- A polymorphism in the Irisin-encoding gene (FNDC5) associates with hepatic steatosis by differential miRNA binding to the 3’UTR Mayada Metwally, Ali …
- B29 RESPIRATORY MUSCLE AT WORK: IS IT’ALL ABOUT THAT BASS’?: Expression Of The Irisin Precursor Fndc5 In Quadriceps Muscle Of COPD Patients …
- Pentamethylquercetin counteracts obesity and drives brown fat-like phenotype through AMPK-mediated activation of PGC-1 alpha/FNDC5 pathway in muscle
- Maternal Low Protein Diet Reduces Birth Weight And Increases Brown Adipose Tissue UCP‐1 and FNDC5 Gene Expression in Male Neonatal Sprague‐Dawley Rats
