Speculating about PYRAZINES The PYRAZINES. Synthesis of imidazo [1, 2-a] annulated pyridines, PYRAZINES and pyrimidines by a novel three-component condensation Recent advances in development of imidazo [1, 2-a] PYRAZINES: synthesis, reactivity and their biological applications Microwave-accelerated three-component condensation reaction on clay: solvent-free synthesis of imidazo [1, 2-a] annulated pyridines, PYRAZINES and pyrimidines Structure–activity relationships of furazano [3, 4-b] PYRAZINES as mitochondrial uncouplers Direct Synthesis of Chiral 1,2,3,4-Tetrahydropyrrolo[1,2-a]PYRAZINES via a Catalytic Asymmetric Intramolecular Aza-Friedel–Crafts Reaction One-step synthesis of dialkynyl-1, 2-diones and their conversion to fused PYRAZINES bearing enediyne units Discovery of 8-Amino-imidazo[1,5-a]PYRAZINES as Reversible BTK Inhibitors for the Treatment of Rheumatoid Arthritis Structure-Based Drug Design of Novel Potent and Selective Tetrahydropyrazolo[1,5-a]PYRAZINES as ATR Inhibitors Synthesis of Tetrahydropyrrolo/indolo [1, 2-a] PYRAZINES by Enantioselective Hydrogenation of Heterocyclic Imines Piperazinylimidazo [1, 2-a] PYRAZINES with selective affinity for in vitro. alpha.-adrenergic receptor subtypes Identification of 2-amino-5-aryl-PYRAZINES as inhibitors of human lactate dehydrogenase Cascade synthesis of indolizines and pyrrolo [1, 2-a] PYRAZINES from 2-formyl-1-propargylpyrroles Novel thieno-[3, 4-b]-PYRAZINES cored dendrimers with carbazole dendrons: design, synthesis, and application in solution-processed red organic light-emitting diodes Thieno[3,4-b]PYRAZINES:  Synthesis, Structure, and Reactivity Discovery of Imidazo[1,2-a]PYRAZINES and Pyrazolo[1,5-c]pyrimidines as TARP γ-8 Selective AMPAR Negative Modulators 2,3-Diphenylthieno[3,4-b]PYRAZINES as Hole-Transporting Materials for Stable, High-Performance Perovskite Solar Cells PYRAZINES in foods Pyrido[4,3-e][1,2,4]triazolo[4,3-a]PYRAZINES as Selective, Brain Penetrant Phosphodiesterase 2 (PDE2) Inhibitors Brönsted acid hydrotrope combined catalyst for environmentally benign synthesis of quinoxalines and pyrido [2, 3-b] PYRAZINES in aqueous medium PYRAZINES: occurrence, formation and biodegradation Control strategies of PYRAZINES generation from Maillard reaction General microwave-assisted protocols for the expedient synthesis of quinoxalines and heterocyclic PYRAZINES Combretastatin A-4 inspired novel 2-aryl-3-arylamino-imidazo-pyridines/PYRAZINES as tubulin polymerization inhibitors, antimitotic and anticancer agents Parallel synthesis of 3-aminoimidazo [1, 2-a] pyridines and PYRAZINES by a new three-component condensation Assembly of 1,2,3,4-Tetrahydropyrrolo[1,2-a]PYRAZINES via the Domino Reaction of 2-Imidazolines and Terminal Electron-Deficient Alkynes Synthesis, biological evaluation and molecular modeling study of 2-amino-3, 5-disubstituted-PYRAZINES as Aurora kinases inhibitors Imidazo [1, 2-a] pyrimidines and imidazo [1, 2-a] PYRAZINES: the role of nitrogen position in inotropic activity Synthesis and evaluation of imidazo [1, 5-a] PYRAZINES as corticotropin releasing hormone receptor ligands Characterization of PYRAZINES in some Chinese liquors and their approximate concentrations PYRAZINES: Synthesis and industrial application of these valuable flavor and fragrance compounds The biological roles of PYRAZINES: evidence for a warning odour function Influence of free amino acids, oligopeptides, and polypeptides on the formation of PYRAZINES in Maillard model systems Preparation of quinoxalines, dihydroPYRAZINES, PYRAZINES and piperazines using tandem oxidation processes Advances in the directed metallation of azines and diazines (pyridines, pyrimidines, PYRAZINES, pyridazines, quinolines, benzodiazines and carbolines). Part 1 … … Modeling of New Pyrrolo[1,2-a]quinoxalines, Bispyrrolo[1,2-a]quinoxalines, Bispyrido[3,2-e]pyrrolo[1,2-a]PYRAZINES, and Bispyrrolo[1,2-a]thieno[3,2-e]PYRAZINES Preparation of Pyrido-(2, 3)-PYRAZINES, Pyrido-(3, 4)-PYRAZINES and Imidazo-(b)-pyridines 2-and 3-substituted imidazo [1, 2-a] PYRAZINES as inhibitors of bacterial type IV secretion Design and evaluation of 3, 6-di (hetero) aryl imidazo [1, 2-a] PYRAZINES as inhibitors of checkpoint and other kinases Synthesis of 2, 3-disubstituted PYRAZINES and quinoxalines by Heck cross-coupling reactions of 2, 3-dichloropyrazine and 2, 3-dichloroquinoxaline. Influence of the … … of azines and

The biology of PGC-1α and its therapeutic potential PGC-1α: a key regulator of energy metabolism PGC-1α-mediated adaptations in skeletal muscle PGC-1α and PGC-1β regulate mitochondrial density in neurons Bioenergetic analysis of peroxisome proliferator-activated receptor γ coactivators 1α and 1β (PGC-1α and PGC-1β) in muscle cells Multiple environmental and genetic factors influence skeletal muscle PGC-1α and PGC-1β gene expression in twins … PGC-1α) coactivates the cardiac-enriched nuclear receptors estrogen-related receptor-α and-γ: identification of novel leucine-rich interaction motif within PGC … Role of PGC‐1α signaling in skeletal muscle health and disease Lipin 1 is an inducible amplifier of the hepatic PGC-1α/PPARα regulatory pathway PGC-1α: turbocharging mitochondria Impaired PGC-1α function in muscle in Huntington's disease PGC-1α, a new therapeutic target in Huntington's disease? PGC-1α in aging and anti-aging interventions PGC-1α regulation by exercise training and its influences on muscle function and insulin sensitivity Peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α): transcriptional coactivator and metabolic regulator PGC-1α supports glutamine metabolism in breast cancer FGF15/19 regulates hepatic glucose metabolism by inhibiting the CREB-PGC-1α pathway Transcriptional coactivators PGC-1α and PGC-lβ control overlapping programs required for perinatal maturation of the heart Transcriptional control of mitochondrial biogenesis: the central role of PGC-1α … transcription of the peroxisome proliferator-activated receptor-γ co-activator-1α (PGC-1α) gene in skeletal muscle through the PGC-1α autoregulatory loop and … Activation of nuclear receptor coactivator PGC-1α by arginine methylation Regulation of peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) and mitochondrial function by MEF2 and HDAC5 Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1 PGC-1α, mitochondrial dysfunction, and Huntington's disease Metabolic adaptations through the PGC-1α and SIRT1 pathways A fundamental system of cellular energy homeostasis regulated by PGC-1α PGC-1α regulates the mitochondrial antioxidant defense system in vascular endothelial cells Sirtuin 3, a new target of PGC-1α, plays an important role in the suppression of ROS and mitochondrial biogenesis SUMOylation attenuates the function of PGC-1α A role for the transcriptional coactivator PGC-1α in muscle refueling Development of insulin resistance in mice lacking PGC-1α in adipose tissues The estrogen-related receptor α (ERRα) functions in PPARγ coactivator 1α (PGC-1α)-induced mitochondrial biogenesis Regulation of PGC-1α, a nodal regulator of mitochondrial biogenesis Insulin-regulated hepatic gluconeogenesis through FOXO1–PGC-1α interaction Regulation of PPARγ coactivator 1α (PGC-1α) signaling by an estrogen-related receptor α (ERRα) ligand PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's disease Endothelial PGC-1α mediates vascular dysfunction in diabetes IRF4 is a key thermogenic transcriptional partner of PGC-1α PGC-1α regulates the neuromuscular junction program and ameliorates Duchenne muscular dystrophy Fibroblast growth factor 21 regulates energy metabolism by activating the AMPK–SIRT1–PGC-1α pathway PGC-1α expression decreases in the Alzheimer disease brain as a function of dementia The many roles of PGC-1α in muscle—recent developments The role of PGC-1α in the pathogenesis of neurodegenerative disorders The role of PGC-1α on mitochondrial function and apoptotic susceptibility in muscle Metformin induces PGC‐1α expression and selectively affects hepatic PGC‐1α functions PGC-1α is coupled to HIF-1α-dependent gene expression by increasing mitochondrial oxygen consumption in skeletal muscle cells Re-evaluating the FOXO1–PGC-1α connection PGC-1α promotes recovery after

Anti-ovarian cancer potential of phytocompound and extract from South African medicinal plants and their role in the development of chemotherapeutic agents Effect of a combination of extract from several plants on Cell‐mediated and humoral immunity of patients with advanced ovarian cancer Aqueous extract of herba Scutellaria barbatae, a Chinese herb used for ovarian cancer, induces apoptosis of ovarian cancer cell lines The inhibitory effect of ginger extract on ovarian cancer cell line; application of systems biology … , characterization, cytotoxicity, antioxidant, and anti-human ovarian cancer activities of Curcumae kwangsiensis leaf aqueous extract green-synthesized gold … Antitumor activities of Rauwolfia vomitoria extract and potentiation of carboplatin effects against ovarian cancer Effects of Agarum clathratum extract on cell death and calcium ion levels of ovarian cancer cell Huaier aqueous extract inhibits ovarian cancer cell motility via the AKT/GSK3β/β-catenin pathway Synergistic effects of green tea extract and paclitaxel in the induction of mitochondrial apoptosis in ovarian cancer cell lines Evaluation of characteristics of CD44+ CD117+ ovarian cancer stem cells in three dimensional basement membrane extract scaffold versus two dimensional … The fractionated Toona sinensis leaf extract induces apoptosis of human ovarian cancer cells and inhibits tumor growth in a murine xenograft model The induction of apoptosis in human melanoma, breast and ovarian cancer cell lines using an essential oil extract from the conifer Tetraclinis articulata. Emblica officinalis extract Induces Autophagy and Inhibits Human ovarian cancer Cell Proliferation, Angiogenesis, Growth of Mouse Xenograft Tumors The plant extract of Pao pereira potentiates carboplatin effects against ovarian cancer Anti-human ovarian cancer and cytotoxicity effects of nickel nanoparticles green-synthesized by Alhagi maurorum leaf aqueous extract Efficient biogenesis of Cu2O nanoparticles using extract of Camellia sinensis leaf: Evaluation of catalytic, cytotoxicity, antioxidant, and anti-human ovarian cancer … Characterizing the efficacy of fermented wheat germ extract against ovarian cancer and defining the genomic basis of its activity Anti-proliferative and anti-apoptotic effects of grape seed extract on chemo-resistant OVCAR-3 ovarian cancer cells Kaempferia parviflora extract inhibits TNF-α-induced release of MCP-1 in ovarian cancer cells through the suppression of NF-κB signaling Investigation of anti-human ovarian cancer effects of decorated Au nanoparticles on Thymbra spicata extract modified Fe3O4 nanoparticles Antiangiogenesis efficacy of ethanol extract from Amomum tsaoko in ovarian cancer through inducing ER stress to suppress p-STAT3/NF-kB/IL-6 and VEGF … Bitter Melon (Momordica charantia) extract Inhibits Tumorigenicity and Overcomes Cisplatin-Resistance in ovarian cancer Cells Through Targeting AMPK … … -mediated synthesis of CuO nanoparticles using aqueous leaf extract of Artemisia deserti and their anticancer effects on A2780-CP cisplatin-resistant ovarian cancer … Solanum incanum extract downregulates aldehyde dehydrogenase 1-mediated stemness and inhibits tumor formation in ovarian cancer cells … extract from Baiye No.1 Tea (Camellia sinensis) Flowers Induced S Phase Cell Cycle Arrest and Apoptosis via AKT-MDM2-p53 Signaling Pathway in ovarian cancer … Aqueous extract of Paris polyphylla (AEPP) Inhibits ovarian cancer via Suppression of Peroxisome Proliferator-Activated Receptor-Gamma Coactivator (PGC) … Overcoming cisplatin resistance by targeting the MTDH-PTEN interaction in ovarian cancer with sera derived from rats exposed to Guizhi Fuling wan extract

Medicinal plants can prevent breast cancer through various mechanisms and pathways. Some of the ways in which medicinal plants can contribute to breast cancer prevention include: - Antioxidant Activity: Medicinal plants are rich in antioxidants that can neutralize harmful free radicals and protect cells from oxidative damage. - Anti-inflammatory Effects: Medicinal plants have anti-inflammatory properties that can reduce inflammation and potentially inhibit the development of breast cancer. - Hormonal Regulation: Some medicinal plants contain phytoestrogens, which can help regulate hormonal balance and reduce the risk of hormone-related breast cancer. - Immune System Modulation: Medicinal plants can enhance the immune system's ability to recognize and eliminate cancer cells. - Apoptosis Induction: Medicinal plants may contain bioactive compounds that can induce programmed cell death in cancer cells. The pathways that medicinal plants can affect in breast cancer prevention include: - PI3K/Akt Pathway: Medicinal plants can modulate this pathway, which is involved in cell growth, survival, and proliferation. The PI3K/Akt pathway plays a crucial role in breast cancer development and progression. Dysregulation of this pathway is commonly observed in breast cancer and is associated with tumor growth, metastasis, and resistance to therapy. The pathway can be activated through various mechanisms, including PI3K activation, Akt activation, and downstream signaling. Genetic alterations, receptor tyrosine kinase activation, and loss of negative regulators can lead to pathway activation. The activation of the PI3K/Akt pathway in breast cancer has implications for tumor growth and survival, metastasis, and resistance to therapy. Targeting this pathway has emerged as a potential therapeutic strategy, and several inhibitors are being investigated in clinical trials for the treatment of breast cancer. - NF-κB Pathway: Medicinal plants can inhibit this pathway, which is associated with inflammation and cell survival. The NF-κB pathway is a critical signaling pathway involved in various cellular processes, including inflammation, immune response, cell survival, and proliferation. In breast cancer, the NF-κB pathway is dysregulated and plays a significant role in tumor growth, invasion, metastasis, and resistance to therapy. Activation of the NF-κB pathway in breast cancer can occur through various mechanisms, such as the activation of cell surface receptors and genetic alterations in pathway components. Once activated, NF-κB translocates to the nucleus and regulates the expression of genes involved in cell survival, proliferation, angiogenesis, and inflammation. Targeting the NF-κB pathway has been explored as a potential therapeutic strategy for breast cancer, with inhibitors of NF-κB signaling showing promise in preclinical studies and clinical trials. However, further research is needed to fully understand the complex regulation of the NF-κB pathway in breast cancer and to develop effective and safe therapeutic interventions. - Wnt Pathway: Medicinal plants can influence this pathway, which plays a role in cell proliferation and tumor development. The Wnt pathway is a critical signaling pathway involved in various cellular processes, including embryonic development, tissue homeostasis, and cell proliferation. Dysregulation of the Wnt pathway has been implicated in the development and progression of breast cancer. In breast cancer, aberrant activation of the Wnt pathway can occur through various mechanisms, including

Anti-inflammatory effects of the Nigella sativa seed extract, thymoquinone, in pancreatic cancer cells Viscum album [L.] extract therapy in patients with locally advanced or metastatic pancreatic cancer: a randomised clinical trial on overall survival Moringa Oleifera aqueous leaf extract down-regulates nuclear factor-kappaB and increases cytotoxic effect of chemotherapy in pancreatic cancer cells Anticancer effect of ginger extract against pancreatic cancer cells mainly through reactive oxygen species-mediated autotic cell death Ginkgo biloba extract kaempferol inhibits cell proliferation and induces apoptosis in pancreatic cancer cells The effect of asparagus extract on pancreatic cancer: an intriguing surprise Holy Basil leaf extract decreases tumorigenicity and metastasis of aggressive human pancreatic cancer cells in vitro and in vivo: potential role in therapy … and chemical characterization of a novel anti-human pancreatic cancer supplement by silver nanoparticles containing Zingiber officinale leaf aqueous extract PBI-05204, a supercritical CO2 extract of Nerium oleander, inhibits growth of human pancreatic cancer via targeting the PI3K/mTOR pathway Selective induction of apoptosis and autophagy through treatment with dandelion root extract in human pancreatic cancer cells Treatment of pancreatic insufficiency using pancreatic extract in patients with advanced pancreatic cancer: a pilot study (PICNIC) Impact of curcumin, raspberry extract, and neem leaf extract on rel protein-regulated cell death/radiosensitization in pancreatic cancer cells Inhibition of pancreatic cancer and potentiation of gemcitabine effects by the extract of Pao Pereira Pomegranate extract induces cell cycle arrest and alters cellular phenotype of human pancreatic cancer cells Antitumor Activities of Rauwolfia vomitoria extract and Potentiation of Gemcitabine Effects Against pancreatic cancer pancreatic enzyme extract improves survival in murine pancreatic cancer Hot water extract of Agaricus blazei Murrill specifically inhibits growth and induces apoptosis in human pancreatic cancer cells Yarrow supercritical extract exerts antitumoral properties by targeting lipid metabolism in pancreatic cancer Inhibition of pancreatic cancer stem cells by Rauwolfia vomitoria extract Anticancer activity of a lectin-rich mistletoe extract injected intratumorally into human pancreatic cancer xenografts Autophagy is involved in Ficus carica fruit extract-induced anti-tumor effects on pancreatic cancer Huaier extract restrains pancreatic cancer by suppressing Wnt/β-catenin pathway Feasibility evaluation of emodin (rhubarb extract) as an inhibitor of pancreatic cancer cell proliferation in vitro Molecular mechanisms by which a Fucus vesiculosus extract mediates cell cycle inhibition and cell death in pancreatic cancer cells extract of the medicinal plant Pao Pereira inhibits pancreatic cancer stem-like cell in vitro and in vivo Anti-pancreatic cancer effects of a polar extract from the edible sea cucumber, Cucumaria frondosa Green synthesis of reduced graphene oxide (RGO) using the plant extract of Salvia spinosa and evaluation of photothermal effect on pancreatic cancer cells Total flavonoid aglycones extract in Radix Scutellariae induces cross-regulation between autophagy and apoptosis in pancreatic cancer cells Anti-tumor effect of the extract from qingyihuaji formula on pancreatic cancer by down-regulating Notch-4 and Jagged-1 Effect of Angelica gigas Nakai Ethanol extract and Decursin on Human pancreatic cancer Cells Sedum sarmentosum Bunge extract induces apoptosis and inhibits proliferation in pancreatic cancer cells via the hedgehog signaling pathway Cyathus striatus extract Induces Apoptosis in Human pancreatic