A Bim-Targeting Strategy Overcomes Adaptive Bortezomib Resistance In Myeloma Through A Novel Link Between Autophagy And Apoptosis A Bioinformatic And Mechanistic Study Elicits The Antifibrotic Effect Of Ursolic Acid Through The Attenuation Of Oxidative Stress With The Involvement Of Erk, Pi3K … A Biomolecular Network-Based Strategy Deciphers The Underlying Molecular Mechanisms Of Bupleuri Radix/Curcumae Radix Medicine Pair In The Treatment Of Hepatitis … A Circadian Clock Is Essential For Homeostasis Of Group 3 Innate Lymphoid Cells In The Gut A Common Bim Deletion Polymorphism Mediates Intrinsic Resistance And Inferior Responses To Tyrosine Kinase Inhibitors In Cancer A Complex Oscillating Network Of Signaling Genes Underlies The Mouse Segmentation Clock A Complex Scenario And Underestimated Challenge: The Tumor Microenvironment, Er Stress, And Cancer Treatment A Comprehensive Molecular Interaction Map For Rheumatoid Arthritis A Constitutive BCL2 Down-Regulation Aggravates The Phenotype Of Pkd1-Mutant-Induced Polycystic Kidney Disease A Cooperative Microrna-Tumor Suppressor Gene Network In Acute T-Cell Lymphoblastic Leukemia (T-All) A Curative Cancer Treatment A Cyclin-D1 Interaction With Bax Underlies Its Oncogenic Role And Potential As A Therapeutic Target In Mantle Cell Lymphoma A Delicate Balance–The BCL-2 Family And Its Role In Apoptosis, Oncogenesis, And Cancer Therapeutics A Drug Library Screen Identifies Carbenoxolone As Novel Foxo Inhibitor That Overcomes Foxo3-Mediated Chemoprotection In High-Stage Neuroblastoma A Fate Worse Than Death: Apoptosis As An Oncogenic Process A Functional Role For Transfer Rna-Derived Micrornas In Human B Cells A Genome Scale Rnai Screen Identifies Gli1 As A Novel Gene Regulating Vorinostat Sensitivity A Genome-Wide Association Study Identifies Six Susceptibility Loci For Chronic Lymphocytic Leukemia A Genome-Wide Search For Tumor Suppressor Micrornas In Ovarian Cancer A Global Network Of Transcription Factors, Involving E2A, Ebf1 And Foxo1, That Orchestrates B Cell Fate A Homeostatic Shift Facilitates Endoplasmic Reticulum Proteostasis Through Transcriptional Integration Of Proteostatic Stress Response Pathways A Landscape Of Therapeutic Cooperativity In Kras Mutant Cancers Reveals Principles For Controlling Tumor Evolution A License To Kill: Understanding Natural Killer Cell Licensing To Fight Cancer A Male Infertility Mutation Reverts Nanos1 Activity From Anti-Apoptotic To Pro-Apoptotic By Disrupting Repression Of Gadd45A, Gadd45B, Gadd45G And Rhob Genes A Microtubule Inhibitor, Abt-751, Induces Autophagy And Delays Apoptosis In Huh-7 Cells A Mini Review Of Bisphenol A (Bpa) Effects On Cancer-Related Cellular Signaling Pathways A Miraculous New Therapy In Myeloma? A Multicenter Clinical Study Evaluating The Confirmed Complete Molecular Response Rate In Imatinib-Treated Patients With Chronic Phase Chronic Myeloid Leukemia By … A Mutation In The Viral Sensor 2'-5'-Oligoadenylate Synthetase 2 Causes Failure Of Lactation A Myc-Dependent Division Timer Complements A Cell-Death Timer To Regulate T Cell And B Cell Responses A Myriad Of Roles Of Mir-25 In Health And Disease A Neuroprotective Agent That Inactivates Prodegenerative Trka And Preserves Mitochondria A New Era Of Cardiac Cell Therapy: Opportunities And Challenges A New Stat3-Binding Partner, Arl3, Enhances The Phosphorylation And Nuclear Accumulation Of Stat3 A New Therapeutic Paradigm For Breast Cancer Exploiting Low Dose Estrogen-Induced Apoptosis A Non-Invasive Test For Assessing Embryo Potential By Gene Expression Profiles Of Human Cumulus Cells: A Proof Of Concept
Epigenetic Modifiers Exacerbate Oxidative Stress In Renal Proximal Tubule Cells Epigenetic Modifiers As Anticancer Drugs: Effectiveness Of Valproic Acid In Neural Crest-Derived Tumor Cells Epigenetic Modifiers Exert Renal Toxicity Through Induction Of P66Shc Combining Oncolytic Viruses With Epigenetic Modifiers To Treat Acute Lymphocytic Leukemias The Role Of Epigenetic Modifiers In Hematopoiesis A Screen For Modifiers Of Epigenetic Reprogramming Essay: The Role Of Epigenetic Modifiers In Non-Hodgkin B Cell Lymphoma Combination Of 5-Fluorouracil With Epigenetic Modifiers Induces Radiosensitization, Somatostatin Receptor 2 Expression, And Radioligand Binding In … Key Actors In Cancer Therapy: Epigenetic Modifiers Epigenetic Modifiers Enhance Vesicular Stomatitis Virus-Mediated Oncolysis In The Refractory Pc3 Cell Line. Sub-Acute Exposure Effect Of Selected Polycyclic Aromatic Hydrocarbons On Protein Levels Of Epigenetic Modifiers In Non-Cancerous Hepatic Model Adipogenic Differentiation Potential Of Stem Cells Under The Influence Of The Epigenetic Modifiers 5-Aza-2´-Deoxycytidine And Suberoylanilide Hydroxamic Acid Somatic Variants In Epigenetic Modifiers Can Predict Failure Of Response To Imatinib But Not To Second-Generation Tyrosine Kinase Inhibitors Spliceosome Mutations Exhibit Specific Associations With Epigenetic Modifiers And Proto-Oncogenes Mutated In Myelodysplastic Syndrome The Epigenetic Modifiers 5-Aza-2'-Deoxycytidine And Trichostatin A Influence Adipocyte Differentiation In Human Mesenchymal Stem Cells Candidate Epigenetic Modifiers Of Tau Pathological Burden In Primary Age-Related Tauopathy Epigenetic Modifiers As New Immunomodulatory Therapies In Solid Tumours 5-Hydroxymethylation-Associated Epigenetic Modifiers Of Alzheimer'S Disease Modulate Tau-Induced Neurotoxicity Effects Of Acute Ethanol Exposure On Anxiety Measures And Epigenetic Modifiers In The Extended Amygdala Of Adolescent Rats Targeted Transcriptional Activation Of Silent Oct4 Pluripotency Gene By Combining Designer Tales And Inhibition Of Epigenetic Modifiers An Efficient Method For Generation Of Bi-Allelic Null Mutant Mouse Embryonic Stem Cells And Its Application For Investigating Epigenetic Modifiers Identification Of Cryptosporidium Kinases And Epigenetic Modifiers As Potential Drug Targets Using A Chemical Genetics Approach Changes In Immunogenicity Of Chronic Lymphocytic Leukemia Cells Mediated By Epigenetic Modifiers Restoring The Functional Immunogenicity Of Chronic Lymphocytic Leukemia Using Epigenetic Modifiers. Ex Vivo Expansion Of Human Mobilized Peripheral Blood Stem Cells Using Epigenetic Modifiers Association Between Micro-Rna And Epigenetic Modifiers Dna Methyltransferases (Dnmts), Histone Deacetylases (Hdacs) In Multiple Myeloma (Mm) And … Mutations In Epigenetic Modifiers In The Pathogenesis And Therapy Of Acute Myeloid Leukemia Transient Activation Of Inflammatory Molecules By Epigenetic Modifiers Likely Plays A Role In Expansion Of Transplantable Human Cord Blood Stem/Progenitor Cells Leukemic Pattern Of Hox Gene Expression Is Driven By Genetic Aberrations Through Epigenetic Modifiers Integrated Genome Sequencing Reveals Frequent Loss Of Function Alterations Of Arid1A And Other Epigenetic Modifiers In Sezary Syndrome Epigenetic Modifying Drugs Inhibit Mds/Aml Cell Growth Through Selective Disruption Of The Interactions Between Lineage-Determining Transcription Factors And … Somatic Mutations In Epigenetic Modifiers Identified Using Next Generation Sequencing (Ngs) In Diagnostic Samples Of Cml-Cp Can Predict Poor Outcome On Imatinib … North American Adult T Cell Leukemia Lymphoma (Atll) Is Characterized By Distinct, Therapeutically Targetable Mutations In Epigenetic Modifiers Impact Of Mutations In Epigenetic Modifiers In Acute Myeloid Leukemia: A Systematic Review And Meta-Analysis Gene Alterations In Epigenetic Modifiers And Jak-Stat Signaling Are Frequent In Breast Implant–Associated Alcl Epigenetic
Evading apoptosis in cancer Carcinogenesis is a mechanistically complex and variable process with a plethora of underlying genetic causes. Cancer development consists of a multitude of steps that occur progressively starting with initial driver mutation(s), to tumorigenesis, and ultimately metastasis. During these transitions, cancer cells accumulate a series of genetic alterations that confer upon the cells an unwarranted survival and proliferative advantage. During the course of development, however, cancer cells also encounter a physiologically ubiquitous cellular program that aims to eliminate damaged or abnormal cells: Apoptosis. Thus, it is essential that cancer cells acquire instruments to circumvent programmed cell death. Here we discuss emerging evidence indicating how cancer cells adopt various strategies to override apoptosis including amplifying the anti-apoptotic machinery, downregulating the pro-apoptotic program, or both. Roles of Apoptosis and Cellular Senescence in Cancer and Aging. Cancer and aging are two similar processes representing the final outcome of timedependent accumulation of various irreversible dysfunctions, mainly caused by stress-induced DNA and cellular damages. Apoptosis and senescence are two types of cellular response to damages that are altered in both cancer and aging, albeit through different mechanisms. Carcinogenesis is associated with a progressive reduction in the ability of the cells to trigger apoptosis and senescence. In contrast, in aging tissues, there is an increased accumulation of senescent cells, and the nature of apoptosis deregulation varies depending on the tissue. Thus, the prevailing model suggests that apoptosis and cellular senescence function as two essential tumor-suppressor mechanisms, ensuring the health of the individual during early and reproductive stages of life, but become detrimental and promote aging later in life. The recent discovery that various anticancer agents, including canonical inducers of apoptosis, act also as inducers of cellular senescence indicates that pro-senescence strategies may have applications in cancer prevention therapy. Therefore, dissection of the mechanisms mediating the delicate balance between apoptosis and cellular senescence will be beneficial in the therapeutic exploitation of both processes in the development of future anticancer and anti-aging strategies, including minimizing the side effects of such strategies. Here, we provide an overview of the roles of apoptosis and cellular senescence in cancer and aging. Cellular senescence (CS) is initially defined as an irreversible growth arrest of normal somatic cells, and has been proposed to contribute to tissue and organismal aging itself, and to be an intrinsic safeguard against tumor progression (1). SCs have been shown to have diverse phenotypes, including cellular flattening and hypertrophy, senescence-associated β-galactosidase activity (SAβG), senescence-associated secretory phenotype (SASP), resistance to apoptotic cell death, alterations in nuclear structure and senescence-associated heterochromatic foci (SAHF), mitochondrial expansion, and signaling events, including upregulation of cell cycle inhibitors and -pro-survival effectors (2). SCs accumulated in various tissues in mice with age, and comprised 5–40% of the total cells, depending on the tissue types (3). Although their number are relatively small in tissues, SCs can cause extensive dysfunction of the microenvironment and damage to surrounding cells and tissues, due to their pro-inflammatory senescence-associated secretory phenotype (SASP). Accumulating evidence suggests that CS plays an
The release of cytokines is central to almost every stage of the immune response to allergens... how do you turn down the cytokines and stop the body from having an allergic reaction? Flavonoids and Polyphenols! … -[Beta] c Receptor Antibody Targets Multiple Effector Cell Populations In Human Nasal Polyps Transplanted Into Immunodeficient Transgenic Human Interleukin-3 (il-3 … … , M; Rolla, G; Ricciardolo, Flm. Nasal IL-17F is related to bronchial IL-17F/neutrophilia and exacerbations in stable atopic severe asthma.. allergy . 70 (2) pp … … , Park JM, Oh CK:(S, S)-formoterol increases the production of IL-4 in mast cells and the airways of a murine asthma model. Int Arch allergy Immunol 133: 380 … … allergy AND AIRWAY INFLAMMATION: Increased Vascularity Of The Bronchial Mucosa In Patients With Severe Asthma And The Role Of Il-17a In Angiogenesis … … and CD19low B Cells in Non-IgEMediated Food allergy of Late Eczematous Reactions in Atopic Dermatitis: Presence of IL-17-and IL-32-Producing Regulatory B … … are Associated with Increased IL-4 but not GATA-3 Expression from Antigen-Stimulated Leukocytes in Atopic Infants (COFAR Observational Study of Food allergy ) … blood cell sulfidoleukotriene generation in the presence of interleukin-3 and whole blood histamine release in honey bee and yellow jacket venom allergy . … immunotherapy on the clinical condition and plasma levels of cytokines IL-4, IL-5, IL-12 and IFNγ and total IgE in patients with seasonal allergy during the Pollen … … Interactions During an Allergic Patch Test Reaction. Increased Activity of ETAF/IL-1, epidermal derived lymphocyte reactivity in persons with type IV allergy … M, Varricchi G, Passalacqua G, Canonica GW. A Critical Evaluation of Anti-IL-13 and Anti-IL-4 Strategies in Severe Asthma. Int Arch allergy Immunol. 2016; 170 … … of Epstein–Barr virus (EBV)-infected natural killer (NK) cell proliferation in patients with severe mosquito allergy ; establishment of an IL-2-dependent NK-like … … of IL-6, and IL-12, and the Chemotactic Cytokine RANTES in Patients with Chronic Sinusitis and Polypoid Disease Clinical Relevance and Relation to allergy … on From Molecular Science to the Treatment of allergy , Corfu, Greece, September 12-16 1998: Mechanisms and pharmacologic control of basophil-derived IL-4 and IL … … Smoke and IL-4 Polymorphism (C-589T) Gene: Environment Interaction Increases Risk of Wheezing in African-American Infants: The Cincinnati Childhood allergy … … To Staphylococcus Aureus Particles Promotes Development Of Antigen-Specific Th2-Type Immunity To Inhaled Antigens Through Production Of Interleukin-1 [alpha](il … 105A/C IL-18 GENE SINGLE NUCLEOTIDE POLYMORPHISM AND HOUSE DUST MITE allergy IN A FILIPINO POPULATION 197 Impaired IL-4-Associated Generation of CCR4-Expressing T Cells in Neonates at Hereditary allergy Risk 23 IL-4 AND IFN-γ PRODUCTION BY LONG TERM T CELL CULTURES IN IgE-MEDIATED COW'S MILK allergy (CMA) A Mouse Model of Mosquito allergy for Study of Antigen–Specific IgE and IgG Subclass Responses, Lymphocyte Proliferation, and IL–4 and IFN–Á Production A novel approach to specific allergy treatment: the recombinant allergen-S-layer fusion protein rSbsC-Bet v 1 matures dendritic cells that prime Th0/Th1 and IL-10 … A possible role of elevated breast milk lactoferrin and the cytokine
Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized Targeting BCL-2 with the BH3 mimetic ABT-199 in estrogen receptor-positive breast cancer Bim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic Gossypol, a BH3 mimetic, induces apoptosis in chronic lymphocytic leukemia cells Sensitization of BCL-2–expressing breast tumors to chemotherapy by the BH3 mimetic ABT-737 The BH3-mimetic GX15-070 synergizes with bortezomib in mantle cell lymphoma by enhancing Noxa-mediated activation of Bak The Bcl-2 specific BH3 mimetic ABT-199: a promising targeted therapy for t (11; 14) multiple myeloma Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa A BH3 mimetic for killing cancer cells ABT-199, a new Bcl-2–specific BH3 mimetic, has in vivo efficacy against aggressive Myc-driven mouse lymphomas without provoking thrombocytopenia Initial testing (stage 1) of the BH3 mimetic ABT‐263 by the pediatric preclinical testing program Treatment of B-RAF mutant human tumor cells with a MEK inhibitor requires Bim and is enhanced by a BH3 mimetic A natural BH3 mimetic induces autophagy in apoptosis-resistant prostate cancer via modulating Bcl-2–Beclin1 interaction at endoplasmic reticulum BH3 mimetic obatoclax enhances TRAIL-mediated apoptosis in human pancreatic cancer cells BH3 mimetic ABT-737 potentiates TRAIL-mediated apoptotic signaling by unsequestering Bim and Bak in human pancreatic cancer cells In vitro effects of the BH3 mimetic,(−)-gossypol, on head and neck squamous cell carcinoma cells Acquired mutations in BCL2 family proteins conferring resistance to the BH3 mimetic ABT-199 in lymphoma A novel BH3 mimetic reveals a mitogen-activated protein kinase–dependent mechanism of melanoma cell death controlled by p53 and reactive oxygen species The BH3 mimetic compound, ABT-737, synergizes with a range of cytotoxic chemotherapy agents in chronic lymphocytic leukemia Reversal of cisplatin resistance with a BH3 mimetic,(−)-gossypol, in head and neck cancer cells: role of wild-type p53 and Bcl-xL Activity of vincristine, L-ASP, and dexamethasone against acute lymphoblastic leukemia is enhanced by the BH3-mimetic ABT-737 in vitro and in vivo BH3 mimetic ABT-737 neutralizes resistance to FLT3 inhibitor treatment mediated by FLT3-independent expression of BCL2 in primary AML blasts Modulation of NOXA and MCL-1 as a strategy for sensitizing melanoma cells to the BH3-mimetic ABT-737 MET-independent lung cancer cells evading EGFR kinase inhibitors are therapeutically susceptible to BH3 mimetic agents BH3 mimetic ABT-737 and a proteasome inhibitor synergistically kill melanomas through Noxa-dependent apoptosis Targeting Bcl-2 family members with the BH3 mimetic AT-101 markedly enhances the therapeutic effects of chemotherapeutic agents in in vitro and in vivo models of B … BCL-2 phosphorylation modulates sensitivity to the BH3 mimetic GX15-070 (Obatoclax) and reduces its synergistic interaction with bortezomib in chronic … A novel BH3 mimetic S1 potently induces Bax/Bak‐dependent apoptosis by targeting both Bcl‐2 and Mcl‐1 A phase 2 study of the BH3 mimetic BCL2 inhibitor navitoclax (ABT-263) with or without rituximab, in previously untreated B-cell chronic
“Photoaging is the term used to describe the clinical, histologic, and functional changes in chronically sun-exposed skin of middle-aged and elderly adults. The importance of photoaging lies in its cosmetic and hence psychosocial impact on a large percentage of older adults, its intimate but incompletely understood relationship to skin cancer, as well as various functional losses in skin, and the model it provides for studies of adverse environmental effects on human health. Photoaging is widely presumed to have an adverse effect on essentialy all skin functions, although very few controlled data exist to support this belief. Nuclear atypia and often some degree of disordered keratinocyte maturation are present in moderate to severe photoaging. The depth and severity of the changes are dependent on skin type and the degree of photoaging. The different characteristics of mild, moderate, and severe photoaging in lightly pigmented vs. darkly pigmented skin may also reflect the characteristic response pattern of many cells to increasing injury.” “Chronic sun exposure causes photoaging of human skin, a process that is characterized by clinical, histological and biochemical changes which differ from alterations in chronologically aged but sun‐protected skin. Within recent years, substantial progress has been made in unraveling the underlying mechanisms of photoaging. Induction of matrix metalloproteinases as a consequence of activator protein (AP)‐1 and nuclear factor (NF)‐κB activation as well as mutations of mitochondrial DNA have been identified recently. This has increased our understanding of photoaging significantly and has led to new prophylactic and therapeutic strategies aimed at the prevention and repair of the detrimental effects of chronic sun‐exposure on the skin.” … epidermal barrier function, are 3-hydroxy-3-methylglutaryl-coenzyme A reductase activators, useful to eg fight against signs of cutaneous aging and photoaging 009 skin aging and photoaging effects can be quantified in vivo by fluoresence excitation spectroscopy A dermatologist's ammunition in the war against smoking: a photoaging app A full‐UV spectrum absorbing daily use cream protects human skin against biological changes occurring in photoaging A mixture of extracts of Kochia scoparia and Rosa multiflora with PPAR α/γ dual agonistic effects prevents photoaging in hairless mice A novel anti-photoaging ingredient with the effect of iron sequestering A novel in vivo model for evaluating agents that protect against ultraviolet A-induced photoaging A nuclear factor kappa B-derived inhibitor tripeptide inhibits UVB-induced photoaging process A Peptide YGDEY from Tilapia Gelatin Hydrolysates Inhibits UVB‐mediated skin photoaging by Regulating MMP‐1 and MMP‐9 Expression in HaCaT Cells Adaptive and maladaptive responses in skin: mild heat exposure protects against UVB-induced photoaging in mice Adaptive antioxidant response and photoaging ADSCs inhibit photoaging‐and photocarcinogenesis‐related inflammatory responses and extracellular matrix degradation Advance in Botanical Extract in the Prevention of photoaging [J] Aging-and photoaging-dependent changes of enzymic and nonenzymic antioxidants in the epidermis and dermis of human skin in vivo Alpha-pinene attenuates UVA-induced photoaging through inhibition of matrix metalloproteinases expression in mouse skin An Endogenous Dermal Fluorescence Band that may Serve as a Quantitative Marker of Aging and Photoaging An extract of Polypodium leucotomos inhibits ultraviolet B photoaging in the
A 4-Week Repeated Oral Dose Toxicity Study Of Fucoidan From The Sporophyll Of Undaria Pinnatifida In Sprague–Dawley Rats A Case Of Symptomatic Inflammatory Tongue Treated With Fucoidan A Comparative Study Of Antithrombotic Activities Of Fucoidan With Different Molecular Weight And Its Mechanism A Comparison Of Fucoidan Conjugated To Paclitaxel And Curcumin For The Dual Delivery Of Cancer Therapeutic Agents A Comparison Of The Effect Of Fucoidan From Alga Fucus Vesiculosus And Its Fractions Obtained By Anion-Exchange Chromatography On Hela G-63, Hep G2, And Chang … A Fluorometric Assay For Quantification Of Fucoidan, A Sulfated Polysaccharide From Brown Algae A Fucoidan Fraction From Ascophyllum Nodosum A Fucoidan Fraction Purified From Chnoospora Minima; A Potential Inhibitor Of Lps-Induced Inflammatory Responses A Fucoidan From Nemacystus Decipiens Disrupts Angiogenesis Through Targeting Bone Morphogenetic Protein 4 A Fucoidan From Sea Cucumber Pearsonothuria Graeffei With Well-Repeated Structure Alleviates Gut Microbiota Dysbiosis And Metabolic Syndromes In Hfd-Fed Mice A Fucoidan-Quaternary Chitosan Nanoparticle Adjuvant For Anthrax Vaccine As An Alternative To Cpg Oligodeoxynucleotides A Highly Regular Fraction Of A Fucoidan From The Brown Seaweed Fucus Distichus L. A Low Molecular Weight Fucoidan Fraction From The Brown Seaweed Pelvetia Canaliculata A Marine Strain Of Flavobacteriaceae Utilizes Brown Seaweed Fucoidan A Marine-Sourced Fucoidan Solution Inhibits Toll-Like-Receptor-3-Induced Cytokine Release By Human Bronchial Epithelial Cells A Method For Coating Fucoidan Onto Bare Metal Stent And In Vivo Evaluation A New Extraction Method Of Fucoidan From The Soaked Water Of Brown Seaweed (Laminaria Japonica) A New Route Of Fucoidan Immobilization On Low Density Polyethylene And Its Blood Compatibility And Anticoagulation Activity A Novel Rutin-Fucoidan Complex Based Phytotherapy For Cervical Cancer Through Achieving Enhanced Bioavailability And Cancer Cell Apoptosis A Promising Oral Fucoidan-Based Antithrombotic Nanosystem: Development, Activity And Safety A Quantitative Method To Detect Fucoidan In Human Plasma Using A Novel Antibody. A Randomized Placebo-Controlled Trial Of An Oral Preparation Of High Molecular Weight Fucoidan In Patients With Type 2 Diabetes With Evaluation Of Taste Sensitivity A Review About The Development Of Fucoidan In Antitumor Activity: Progress And Challenges A Review Of The Usability Of Fucoidan Extracted From Brown Seaweed As A Functional Ingredient Of Cosmetics A Revised Structure For Fucoidan May Explain Some Of Its Biological Activities. A Study Of Fucoidan From The Brown Seaweed Chorda Filum A Study On The Anticoagulant And Fibrinolytic Activities Of A Crude Fucoidan From The Edible Brown Seaweed Laminaria Religiosa, With Special Reference To Its Inhibitory … A Sulfated Polysaccharide, Fucoidan, Enhances The Immunomodulatory Effects Of Lactic Acid Bacteria A001 Affinity Of Low Molecular Weight Fucoidan For P-Selectin Triggers Its Binding To Activated Human Platelets Ability Of Fucoidan To Prevent Muscle Necrosis Induced By Snake Venom Myotoxins: Comparison Of High-And Low-Molecular Weight Fractions Abstract A47: Fucoidan From Laminaria Cichorioides Inhibits Ap‐1 Transactivation And Cell Transformation In Mouse Epidermal Jb6 Cells Accumulation Of Fibronectin In Articular Cartilage Explants Cultured With Tgfβ1 And Fucoidan Acid-Promoted Synthesis Of Per-O-Sulfated Fucooligosaccharides Related To Fucoidan Fragments Activation Of Caspase-8 Contributes To Fucoidan-Induced Apoptosis In Ht-29 Human Colon Cancer Cells Activation Of Nk
A Role For Somatostatin In The Impaired insulin Secretory Response To glucose By Islets From Aging Rats A Study Of The Effect Of Aging On insulin And Glueagon Release During Intravenous glucose Tolerance Test Ability Of insulin To Modulate Hepatic glucose Production In Aging Rats Is Impaired By Fat Accumulation Accumulation Of Advanced glycation Endproducts In Aging Male Fischer 344 Rats During Long-Term Feeding Of Various Dietary carbohydrate s Adrenergic And Cholinergic Mediated glucose Oxidation By Rat Parotid Gland Acinar Cells During Aging Ageloc Vitality Improves Endurance Exercise, Exercise glucose Metabolism And Antioxidant Capacity In An Aging Model Aging Alters glucose Uptake In The Naïve And Injured Rodent Spinal Cord Aging Alters The Circadian Rhythm Of glucose Utilization In The Suprachiasmatic Nucleus Aging And cancer : Is glucose A Mediator Between Them? Aging And glucose Homeostasis In C57Bl/6J Male Mice. Aging And glucose Transporter Plasticity In Response To Hypobaric Hypoxia Aging And High Concentrations Of glucose Potentiate Injury To Mitochondrial Dna Aging And Ovariectomy Cause A Decrease In Brain glucose Consumption In Vivo In Wistar Rats Aging And Presbycusis: Effects On 2-Deoxy-D-Glucose Uptake In The Mouse Auditory Brain Stem In Quiet Aging And The Disposition Of glucose Aging Changes Tissue-Specific glucose Metabolism In Rats Aging Does Not Aggravate The Pregnancy-Induced Adaptations In glucose Tolerance In Rats Aging Exaggerates glucose Intolerance Following Injury. Aging Impairs Insulin-Stimulated glucose Uptake In Rat Skeletal Muscle Via Suppressing Ampkα Aging In Vitro And D‐Glucose Uptake Kinetics Of Diploid Human Fibroblasts Aging Increases Susceptibility To Western Diet-Induced glucose Intolerance And insulin Resistance In Mice Aging Is Associated With Increased Hba1C Levels, Independently Of glucose Levels And insulin Resistance, And Also With Decreased Hba1C Diagnostic Specificity Aging Is Associated With Increased Susceptibility To Western Diet-Induced glucose Intolerance And Endothelial Dysfunction In Mice Aging Of Membrane Transport Mechanisms In The Central Nervous System—2-Deoxy-D-Glucose Transport In Cortical Synaptosomes From The Long-Evans Rat Aging Of Proteins And Nucleic Acids: What Is The Role Of glucose ? Aging Of Proteins: Immunological Detection Of A glucose -Derived Pyrrole Formed During Maillard Reaction In Vivo. Aging Of Proteins: Isolation And Identification Of A Fluorescent Chromophore From The Reaction Of Polypeptides With glucose Aging Per Se Does Not Influence glucose Homeostasis: In Vivo And In Vitro Evidence Aging Per Se Does Not Influence Postprandial glucose Levels In Type 2 diabetes Aging , Acute Oxidative Injury And Hepatocellular glucose Transport In The Rat Aging , glucose Metabolism, And diabetes : Current Concepts. Aging , Vascular Risk, And Cognition: Blood glucose , Pulse Pressure, And cognitive Performance In Healthy Adults. Aging : Drugs To Eliminate Methylglyoxal, A Reactive glucose Metabolite, And Advanced glycation Endproducts Aging -Related Changes Of Inorganic Compound Leaching And carbohydrate s In Pyracantha Angustifolia Seeds Aging -Related Correlation Of Insulin-Degrading Enzyme With Γ-Secretase-Generated Products Involving insulin And glucose Levels In Transgenic Mice Alterations In The Ultradian Oscillations Of insulin Secretion And Plasma glucose In Aging Alterations Of Band 3 Transport Protein By Cellular Aging And Disease: Erythrocyte Band 3 And glucose Transporter
A glaucolide-type sesquiterpene lactone from Vernonia galamensis ssp. nairobensis A review of plant species assessedin vitro for antiamoebic activity or both antiamoebic and antiplasmodial properties A study on the involvement of TLR4/STAT3 signaling in the antimelanoma effects of atractylenolide II/Fu Xiuqiong. Allergic contact dermatitis from sesquiterpenoids of the Compositae family of plants Annexin A2 upregulation protects human retinal endothelial cells from oxygen‑glucose deprivation injury by activating autophagy Antibacterial constituents of the Nepalese medicinal herb, Centipeda minima Antimalarial activity of plant metabolites Antiparasitic activity in Asteraceae with special attention to ethnobotanical use by the tribes of Odisha, India Antiproliferative effects of short-chain fatty acids on human colorectal cancer cells via gene expression inhibition Antiprotozoal activities of Centipeda minima Anti-Protozoal Potential of Heterocyclic Compounds Against Giardiasis Antiviral Activity of the Sesquiterpene Lactones from Centipeda minima against Influenza a Virus in vitro Arnicolide D, from the herb Centipeda minima, Is a Therapeutic Candidate against Nasopharyngeal Carcinoma Baicalein, as a Prooxidant, Triggers Mitochondrial Apoptosis in MCF-7 Human Breast Cancer Cells Through Mobilization of Intracellular Copper and Reactive … Biomarker development for hepatocellular carcinoma early detection: current and future perspectives Bioprospecting for drug research and functional foods for the prevention of diseases—Role of flavonoids in drug development Brevilin A induces apoptosis and autophagy of colon adenocarcinoma cell CT26 via mitochondrial pathway and PI3K/AKT/mTOR inactivation Brevilin A Induces Cell Cycle Arrest and Apoptosis in Nasopharyngeal Carcinoma Brevilin A promotes oxidative stress and induces mitochondrial apoptosis in U87 glioblastoma cells Brevilin A , a novel natural product, inhibits janus kinase activity and blocks STAT3 signaling in cancer cells Brevilin A , a Sesquiterpene Lactone, Inhibits the Replication of Influenza A Virus In Vitro and In Vivo Bulbine frutescens Phytochemicals as a Promising Anti-cancer Drug Discovery Source: A Computational Study Centipeda minima extract exerts antineuroinflammatory effects via the inhibition of NF-κB signaling pathway Chemical constituents from Centipeda minima Constituents of Helenium Species. VII. Bitter Principles of H. pinnatifidum (Nutt.) Rydb., H vernale Walt., H. brevifolium (Nutt.) A. Wood and H. flexuosum Raf.1 Constituents of Helenium species. XXI. Sesquiterpene lactones of Helenium alternifolium. Structures of Brevilin A , linifolin A, and alternilin Cryptotanshinone, a Stat3 inhibitor, suppresses colorectal cancer proliferation and growth in vitro Dehydrocrenatidine is a novel janus kinase inhibitor Detarium microcarpum Stem Bark Extracts Induce Apoptosis in Human Breast Adenocarcinoma MDA MB 231 Cells via cJNK Activation and Mitochondrial Cytochrome … Discovery and evaluation of Atopaxar hydrobromide, a novel JAK1 and JAK2 inhibitor, selectively induces apoptosis of cancer cells with constitutively activated STAT3 EGFL7 promotes hepatocellular carcinoma cell proliferation and inhibits cell apoptosis through increasing CKS2 expression by activating Wnt/β‐catenin signaling Exploring QSAR of antiamoebic agents of isolated natural products by MLR, ANN, and RTO Functions and Implications of Autophagy in Colon Cancer Handbook of compounds with antiprotozoal activity isolated from plants Hecogenin acetate inhibits reactive oxygen species production and induces cell cycle arrest and senescence in the A549 human lung cancer cell line Helenanolides, guaianolide glucosides and other constituents of two Helenium donianum varieties Hepatocellular carcinoma confirmation,
1, 25-Dihydroxyvitamin D3 Treatment Delays Cellular Aging In Human Mesenchymal Stem Cells While Maintaining Their Multipotent Capacity 14Th Napreca Symposium And Aamps Ethnoveterinary Medicine... 1-Deoxynojirimycin Attenuates High Glucose-Accelerated Senescence In Human Umbilical Vein Endothelial Cells 24: Cerebral White Matter Lesions In Formerly (Pre)-Eclamptic Women A Deficit In Collagenase Activity Contributes To Impaired Migration Of Aged Microvascular Endothelial Cells A Drug-Induced Accelerated Senescence (Dias) Is A Possibility To Study Aging In Time Lapse A Functional Study Of Adamts7 Gene Variants. A G2/M Growth Arrest Response To Low-Dose Intermittent H2O2 In Normal Uroepithelial Cells. A Genetic Screening Identifies A Component Of The Swi/Snf Complex, Arid1B As A Senescence Regulator A Method For Fluorescent Hplc Analysis Of Cs/Ds Glycosaminoglycans A New 4-(Pyridinyl)-4H-Benzo[G]Chromene-5,10-Dione Ruthenium(Ii) Complex Inducing Senescence In 518A2 Melanoma Cells A Novel Keratanase‐Generated Keratan Sulfate Antibody And Its Application To Structural Analysis Of Skeletal And Corneal Keratan Sulfate A P53-Dependent Response Limits Epidermal Stem Cell Functionality And Organismal Size In Mice With Short Telomeres A Possible Role Of Stress-Induced Premature Senescence , Sips, As A Producer Of The Stress-Resistant Microenvironment A Study Of Cell Death Pathways And Innate Immunity In Cancer Chemotherapy A Synthetic Formulation, Dhanwantharam Kashaya, Delays Senescence In Stem Cells A Triad Of Nrp2, Dlx And P53 Proteins In Lung Cancer Metastasis Absence Of Replicative Senescence In Cultured Cells From The Short-Lived Killifish Nothobranchius Furzeri Abstract B175: Rational Combination Of Mtor And Aurora Kinase A Inhibition In Preclinical Models Of Triple-Negative Breast Cancer Abstract B63: Differences Between Replicative Senescence -Versus Radiation-Associated Secretory Phenotype Abstract Lb-32: Glioma Treatment With Temozolomide And Notch Inhibition Suppresses Neurosphere Formation And Xenograft Formation Abstract# 2194: Otx2 In Medulloblastoma: Its Function And Targets Accelerated Senescence Of Cord Blood Endothelial Progenitor Cells From Premature Neonates Is Driven By Sirt1 Decreased Expression Accelerated Tubular Cell Senescence In Smp30 Knockout Mice Activation Of A Camp Pathway And Induction Of Melanogenesis Correlate With Association Of P16Ink4 And P27Kip1 To Cdks, Loss Of E2F-Binding Activity, And … Acute Activation Of Amp-Activated Protein Kinase Prevents H2O2-Induced Premature Senescence In Primary Human Keratinocytes Acute Effects Of Rb In Retinoblastoma Cells Acyl-Coenzyme A Synthetase 5 Levels In Urothelial Cellines And Bladder Cancer Tissues Reflect Cellular Differentiation And Senescence . Adamts‐4 Activity On A Proteoglycan Vs. A Polypeptide Is Controlled By The Ancillary Domains Adenoviral P16/Cdkn2 Gene Transfer To Malignant Glioma: Role Of P16 In Growth, Invasion, And Senescence Administration Of L-Arginine Plus L-Citrulline Or L-Citrulline Alone Successfully Retarded Endothelial Senescence Ageing Of Neural Stem Cells In A Parkinson'S Disease Model Age-Like Phenotype Of Microglia During Hiv-1 Infection Age‐Related Changes In Human Meniscal Glycosaminoglycans Aging Alters The Molecular Dynamics Of Synapses In A Sexually Dimorphic Pattern In Zebrafish (Danio Rerio) Aging Decreases Collagen Iv Expression In Vivo In The Dermo-Epidermal Junction And In Vitro In Dermal Fibroblasts: Possible Involvement Of Tgf-Β1 Alain Meybeck Alpha-Ketoglutarate, An Endogenous Metabolite, Extends Lifespan And Compresses Morbidity In Aging Mice Altered Signal Transduction Pathways In Melanoma Alternative Splicing Targeting The Htaf4-Tafh Domain Of Taf4 Represses Proliferation And Accelerates Chondrogenic Differentiation Of