It has been used in Traditional Chinese Medicine for the uses of anti-tumor, anti-microbial, anti-inflammatory and antioxidant.
The increased incidence of apoptosis, identified by characteristic changes in cell morphology, was seen in tumor lines treated with oridonin.
Oridonin inhibits cancer cell growth in a cell cycle specific manner and shifts the balance between pro- and anti-apoptotic proteins in favor of apoptosis. The present data suggest that further studies are warranted to assess the potential of oridonin in cancer prevention and/or treatment.
Anti-Cancer - Ponicidin and oridonin are novel diterpenoids isolated from Rabdosia rubescens. We tested their effects in MCF-7 and MDA-MB-231 cells, as representing low and high invasive breast carcinoma, with normal MCF-10A cells.
These results provide a mechanistic framework for the cellular effects of ponicidin and oridonin in different stage breast cancer cells.
In this study, we examined the inhibitory effects of certain individual components of PC-SPES on the in vitro proliferation of the human