January 16, 2020

MATRIX METALLOPROTEINASES (MMPS)

The role of matrix metalloproteinases in aging “Proteases are a set of enzymes that have been involved in multiple biological processes throughout evolution. Among them, extracellular matrix (ECM) remodeling […]
January 15, 2020

KETOGENIC DIET

The ketogenic diet is a high-fat, adequate-protein, low-carbohydrate diet that in medicine is used primarily to treat difficult-to-control (refractory) epilepsy in children. The diet forces the body to burn fats rather than carbohydrates. […]
January 15, 2020

APOPTOSIS

Apoptosis (from Ancient Greek ἀπόπτωσις “falling off”) is a form of programmed cell death that occurs in multicellular organisms.[2] Biochemical events lead to characteristic cell changes (morphology) and death. These changes include blebbing, cell shrinkage, nuclear fragmentation, chromatin […]
January 14, 2020

SENESCENT CELLS, SASP & SENOLYTICS

SHIPPING APRIL 15TH!!! ZOMBIE CELL KILLER   News Articles:  Both Senolytic Molecules Are Inhibitors Of Particular Members Of The Bcl-2 Family Of Apoptosis Regulatory Proteins And […]
January 10, 2020

MDM2

MDM2 antagonists attenuate the senescence-associated secretory phenotype Processes that have been linked to aging and cancer include an inflammatory milieu driven by senescent cells. Senescent cells […]
January 10, 2020

JNK PREVENTS PREMATURE SENESCENCE

Prevention of premature senescence requires JNK activation Premature senescence is considered as a cellular defense mechanism to prevent tumorigenesis. Although recent evidences show that c-Jun N-terminal […]
January 8, 2020

ONCOGENE ACTIVATION

… : VersicanV1 promotes proliferation and metastasis of hepatocellular carcinoma through the activation of EGFR–PI3K–AKT pathway (oncogene,(2018), 37, 41,(5585 … … and functional interaction between polyoma […]
January 7, 2020

JAK INHIBITION ALLEVIATES SASP

JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age A hallmark of aging is chronic sterile inflammation, which is closely associated with […]
January 7, 2020

PREMATURE SENESCENCE

Premature Senescence ”Senescence is more than merely a cell division clock that regulates the proliferative lifespan of normal cells. “Premature” senescence is an active cytostaticprogram that […]