January 7, 2020

TELOMERE SHORTENING & PREMATURE AGING

A branching process model of telomere shortening A continuous correlation between oxidative stress and telomere shortening in fibroblasts A Critical Role for Pin2/TRF1 in ATM-dependent Regulation […]
January 6, 2020

HSP90

Hsp90 (heat shock protein 90) is a chaperone protein that assists other proteins to fold properly, stabilizes proteins against heat stress, and aids in protein degradation. It also stabilizes a number of proteins […]
January 4, 2020

P53

Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis Human SIR2 deacetylates p53 and antagonizes PML/p53‐induced cellular senescence Senescence and tumour clearance is triggered […]
July 30, 2019

KLOTHO

Klotho is a transmembrane protein that, in addition to other effects, provides some control over the sensitivity of the organism to insulin and appears to be […]
July 28, 2019

FGF21

Regulation of longevity by FGF21: Interaction between energy metabolism and stress responses. Fibroblast growth factor 21 (FGF21) is a hormone-like member of FGF family which controls […]
July 27, 2019

FOXO3

FOXO3 belongs to the O subclass of the forkhead family of transcription factorswhich are characterized by a distinct fork head DNA-binding domain. There are three other […]
July 17, 2019

SIRT1

SIRT1 stands for sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae), referring to the fact that its sirtuinhomolog (biological equivalent across species) in […]
May 1, 2019

AMPK

“5′ AMP-activated protein kinase or AMPK or 5′ adenosine monophosphate-activated protein kinase is an enzyme (EC 2.7.11.31) that plays a role in cellular energy homeostasis, largely […]
April 30, 2019

AUTOPHAGY: 1,000 Scientific Studies

Autophagy (or autophagocytosis) (from the Ancient Greek αὐτόφαγος autóphagos, meaning “self-devouring”[1] and κύτος kýtos, meaning “hollow”[2]) is the natural, regulated mechanism of the cell that removes unnecessary or dysfunctional components.[3] It allows the orderly degradation […]