This study, we also investigated antimicrobial and antioxidant activity of green synthesized AgNPs. The antimicrobial activity is investigated by Bauer et al.’s method. Antioxidant activity was done by DPPH method.
To evaluate the antioxidant effects and apoptotic study of the leaves of Clitoria ternatea and Alternanthra sessilis by using the yeast cell. The yeast cells were isolated from the sugar factory effluents and isolated the yeast cell DNA.
The C. ternatea and A. sessilis leaf extracts treatment effectively decreased the extent of DNA damage. C. ternatea and A. sessilis leaves have the potential antioxidant activity. Thus validating it is a source of valuable antioxidant drugs.
Anti-Hyperglycemic - Alternanthera sessilis is used by folk medicinal practitioners of Bangladesh for alleviation of severe pain. The objective of this study was to scientifically analyze the analgesic (non-narcotic) property of aerial parts of the plant along with antihyperglycemic activity.
Administration of methanol extract of aerial parts led to dose-dependent and significant reductions in blood glucose levels in glucose-loaded mice.
The results validate the folk medicinal use of the plant to alleviate pain. At the same time, the antihyperglycemic activity result suggests that the plant may be a potential source for blood sugar lowering drug(s).
Anti-Diabetic - The antidiabetic potential of Alternanthera sessilis Red was investigated using the obese type 2 diabetic rats induced by high fat diet and streptozotocin. Three fractions (hexane, ethyl acetate, and water) were obtained from the crude ethanol extract of Alternanthera sessilis Red.
ASEAF-treated diabetic rats showed higher pancreatic insulin content and pancreatic total superoxide dismutase activity compared to the untreated diabetic rats. Also, the insulin sensitivity indexes suggested that ASEAF ameliorates the insulin resistant state of the diabetic rats. In conclusion, ASEAF could be developed into a potential antidiabetic agent for the management of type 2 diabetes.
Hepatoprotective -The hepatoprotective effects of the Taiwanese herb ‘Horngtyan‐wu’ (Alternanthera sessilis (L.) DC.) were investigated in three kinds of experimental animal model. Acute hepatitis was induced by various chemicals such as carbon tetrachloride.
All pharmacological and histopathological effects were compared with observations using the hepatoprotective Chinese herb, Bupleurum chinense (Family Umbelliferae). It was confirmed that A. sessilis has hepatoprotective effects against liver injuries induced by hepatotoxins with different mechanisms.
Present study supported the traditional uses of A. sessilis and indicated that the plant can be a potential source of bioactive molecules.
Anti-Cancer - The aqueous extract of Alternanthera sessilis showed significant potential for the quick reduction of silver ions. The synthesized silver nanoparticles were characterized with UV-visible absorption spectrophotometer, XRD, SEM, and FTIR analysis.
The cytotoxic activity of synthesized nanosilver was carried out against prostate cancer cells (PC3) by MTT assay and found to show significant activity. The present work of biosynthesis of silver nanoparticles using Alternanthera sessilis appears to be cost effective, eco-friendly, and an alternative to conventional method of synthesis.
To identify the bioactive extracts from Alternanthera sessilis and investigate its cytotoxicity potential against colon cancer cells, HT-29. The anticancer activities were determined using MTT, clonogenic, cell motility and AOPI assay. The chemical composition profiling was analyzed by GC-MS.
Among three plant part extracts, leaf extract greatly suppressed the growth of colon cancer cells in time and dosage-dependent manner, followed by aerial and stem. The cytotoxicity results were rationalized with clonogenic, cell motility and AO/PI assay, where extract showed the most active activity compared to aerial and stem extracts.
Amid the screened extracts, the leaf extract exhibits the credible cytotoxic, anti-proliferative and apoptotic activity and hence, our findings call for additional research to conclude the active compounds and their mechanisms determining the apoptotic activity.