Apoptosis (from Ancient Greek ἀπόπτωσις “falling off”) is a form of programmed cell death that occurs in multicellular organisms.^[2] Biochemical events lead to characteristic cell changes (morphology) and death. These changes include blebbing, cell shrinkage, nuclear fragmentation, chromatin condensation, chromosomal DNA fragmentation, and global^[vague] mRNA decay. The average adult human loses between 50 and 70 billion cells each day due to apoptosis.^[3][a] For an average human child between the ages of 8 to 14 years old approximately 20 to 30 billion cells die per day.^[5]

In contrast to necrosis, which is a form of traumatic cell death that results from acute cellular injury, apoptosis is a highly regulated and controlled process that confers advantages during an organism’s life cycle. For example, the separation of fingers and toes in a developing human embryo occurs because cells between the digits undergo apoptosis. Unlike necrosis, apoptosis produces cell fragments called apoptotic bodies that phagocytic cells are able to engulf and remove before the contents of the cell can spill out onto surrounding cells and cause damage to them.^[6]

Because apoptosis cannot stop once it has begun, it is a highly regulated process. Apoptosis can be initiated through one of two pathways. In the intrinsic pathway the cell kills itself because it senses cell stress, while in the extrinsic pathway the cell kills itself because of signals from other cells. Weak external signals may also activate the intrinsic pathway of apoptosis.^[7] Both pathways induce cell death by activating caspases, which are proteases, or enzymes that degrade proteins. The two pathways both activate initiator caspases, which then activate executioner caspases, which then kill the cell by degrading proteins indiscriminately.

Research on apoptosis has increased substantially since the early 1990s. In addition to its importance as a biological phenomenon, defective apoptotic processes have been implicated in a wide variety of diseases. Excessive apoptosis causes atrophy, whereas an insufficient amount results in uncontrolled cell proliferation, such as cancer. Some factors like Fas receptors and caspases promote apoptosis, while some members of the Bcl-2 family of proteins inhibit apoptosis. – wiki

SCIENTIFIC STUDIES

1. Mitochondria and Apoptosis
2. Apoptosis Signaling
3. Apoptosis and disease
4. The biochemistry of Apoptosis
5. Mitochondrial control of Apoptosis
6. Apoptosis in cancer
7. Apoptosis by Death Factor
8. Apoptosis in development
9. Apoptosis in AIDS
10. Caspases: the executioners of Apoptosis.
11. Dysregulation of Apoptosis in Cancer
12. Mechanisms of Apoptosis
13. Defining Apoptosis.
14. Apoptosis: Molecular Regulation of Cell Death
15. Neural Apoptosis
16. p53-Dependent Apoptosis pathways
17. Apoptosis in neurodegenerative disorders
18. Calcium orchestrates Apoptosis
19. Apoptosis and carcinogenesis.
20. An evolutionary perspective on Apoptosis
21. Apoptosis – the p53 network
22. Apoptosis in the nervous system
23. JNK signaling in Apoptosis
24. Mitochondria and Apoptosis
25. Apoptosis: an overview
26. Apoptosis-based therapies
27. PI3K: Downstream AKTion Blocks Apoptosis
28. A model for p53-induced Apoptosis
29. Apoptosis regulators.
30. Cell Death: The Significance of Apoptosis
31. Oxidative stress as a mediator of Apoptosis
32. Ceramide: an intracellular signal for Apoptosis
33. Oxidative stress and Apoptosis
34. Apoptosis—an introduction
35. Gonadal cell Apoptosis.
36. Viruses and Apoptosis
37. Mitochondrial dynamics and Apoptosis
38. Mitochondrial control of nuclear Apoptosis
39. Ischemia-induced neuronal Apoptosis
40. Cytochrome C-Mediated Apoptosis
41. Inhibition of Macroautophagy Triggers Apoptosis
42. The molecular biology of Apoptosis
43. Molecular characterization of mitochondrial Apoptosis-inducing factor
44. S-nitrosylation regulates Apoptosis
45. Apoptosis, autophagy, and more
46. Angiogenesis and Apoptosis
47. IAP family proteins—suppressors of Apoptosis
48. Placental Apoptosis in preeclampsia
49. Emerging roles of caspase-3 in Apoptosis
50. Apoptosis in cancer therapy: Crossing the threshold
51. Apoptosis in the Failing Human Heart
52. Phagocyte recognition of cells undergoing Apoptosis
53. Ras signalling and Apoptosis
54. Viruses and Apoptosis
55. Apoptosis. The role of the endonuclease.
56. The morphology of Apoptosis
57. Caspase Family Proteases and Apoptosis
58. Nuclear changes in Apoptosis
59. Immunohistochemical evidence for Apoptosis in Alzheimer’s disease.
60. Control of Apoptosis by p53
61. Mitochondrial fission in Apoptosis
62. Apoptosis and melanoma chemoresistance
63. Apoptosis signaling in lymphocytes.
64. Apoptosis: Molecular Control Point in Toxicity
65. death, and the pursuit of Apoptosis
66. Fas Ligand-Induced Apoptosis
67. Endostatin Induces Endothelial Cell Apoptosis
68. Apoptosis: Mechanisms and Roles in Pathology
69. Induction of Apoptosis by Cancer Chemotherapy
70. Apoptosis: A Review of Programmed Cell Death
71. Apoptosis in resolution of inflammation
72. Mechanisms of p53-dependent Apoptosis
73. The role of DNA fragmentation in Apoptosis
74. Proliferation, cell cycle and Apoptosis in cancer
75. Apoptosis induced by anticancer drugs
76. Apoptosis in the pathogenesis and treatment of disease
77. Injected cytochrome c induces Apoptosis
78. Apoptosis, cancer and cancer therapy
79. ICE-like proteases in Apoptosis
80. Reperfusion injury induces Apoptosis in rabbit cardiomyocytes.
81. The expanding role of mitochondria in Apoptosis
82. Apoptosis signaling by death receptors
83. Death by design: Apoptosis, necrosis and autophagy
84. Mediators of endoplasmic reticulum stress‐induced Apoptosis
85. Apoptosis control by death and decoy receptors
86. Disruption of epithelial cell-matrix interactions induces Apoptosis
87. DNA damage-induced Apoptosis
88. Apoptosis: Activate NF-κB or die?
89. Calpain activation in Apoptosis
90. Advances in Apoptosis research
91. Morphologic and biochemical hallmarks of Apoptosis
92. Apoptosis in yeast
93. Targeting Apoptosis Pathways in Cancer Therapy
94. Apoptosis: Cell death in tissue regulation
95. Apoptosis: controlled demolition at the cellular level
96. Apoptosis induced in normal human hepatocytes by tumor necrosis factor-related Apoptosis-inducing ligand
97. Biochemical Pathways of Caspase Activation During Apoptosis
98. Apoptosis/links/54eb93bd0cf2ff89649df83e/Viruses-and-Apoptosis.pdf”>Viruses and Apoptosis
99. Caspases: key mediators of Apoptosis
100. Translational control in stress and Apoptosis
101. Polyamines and Apoptosis.
102. Caspases in Apoptosis and beyond
103. Apoptosis and calcification.
104. Thymocyte Apoptosis induced by p53-dependent and independent pathways
105. Apoptosis and therapy
106. Calcium signaling and Apoptosis
107. Molecular mechanisms of caspase regulation during Apoptosis
108. Dissecting p53-dependent Apoptosis
109. Chondrocyte Apoptosis induced by nitric oxide.
110. p53 is required for radiation-induced Apoptosis in mouse thymocytes
111. Necrosis and Apoptosis in acute renal failure.
112. Suppression of TNF-α-Induced Apoptosis by NF-κB
113. Nitric Oxide as a Bioregulator of Apoptosis
114. Apoptosis and Caspases in Neurodegenerative Diseases
115. Mitochondria as the central control point of Apoptosis
116. Apoptosis. Its significance in cancer and cancer Therapy
117. Metal-induced Apoptosis: mechanisms
118. Premature p34cdc2 activation required for Apoptosis
119. Apoptosis
120. Protease Activation during Apoptosis: Death by a Thousand Cuts?
121. Serine/Threonine Protein Kinases and Apoptosis
122. Caspases and Apoptosis.
123. Apoptosis-targeted therapies for cancer
124. Control of Apoptosis and mitotic spindle checkpoint by survivin
125. Ligand-Based Targeting of Apoptosis in Cancer: The Potential of Recombinant Human Apoptosis Ligand 2/Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand (rhApo2L/TRAIL)
126. DNA damage-induced cell death by Apoptosis
127. PI3K/Akt and Apoptosis: size matters
128. miR-34a repression of SIRT1 regulates Apoptosis
129. Molecular regulation of Apoptosis: Genetic controls on cell death
130. Extrinsic versus intrinsic Apoptosis pathways in anticancer chemotherapy
131. Induction of Apoptosis in fibroblasts by c-myc protein
132. Apoptosis: A Link between Cancer Genetics and Chemotherapy
133. Apoptosis, oncosis, and necrosis. An overview of cell death.
134. Apoptosis in the Heart
135. Shigella flexneri induces Apoptosis in infected macrophages
136. Two Distinct Pathways Leading to Nuclear Apoptosis
137. Mitogen-activated protein kinases in Apoptosis regulation
138. Apoptosis in Myocytes in End-Stage Heart Failure
139. p53-dependent Apoptosis modulates the cytotoxicity of anticancer agents
140. Apoptosis and Programmed Cell Death in Immunity
141. Endothelial Apoptosis
142. Apoptosis and myocardial infarction
143. Tumor Response to Radiotherapy Regulated by Endothelial Cell Apoptosis
144. T cell Apoptosis by tryptophan catabolism
145. Inhibition of TNF-induced Apoptosis by NF-κB
146. Death and anti-death: tumour resistance to Apoptosis
147. Ion homeostasis and Apoptosis
148. Apoptosis_and_the_skin_100048/article.phtml?cle_doc=000186D0″>Apoptosis and the skin
149. BCL-2 family members and the mitochondria in Apoptosis
150. Radiation and ceramide-induced Apoptosis
151. Apoptosis and ovarian function
152. The Role of Mitochondria in Apoptosis*
153. Tumor resistance to Apoptosis
154. Mechanisms of Caspase Activation and Inhibition during Apoptosis
155. Apoptosis in cancer: from pathogenesis to treatment
156. Cardiolipin and Apoptosis
157. The genetic regulation of Apoptosis
158. Reactive oxygen species, cellular redox systems, and Apoptosis
159. Apoptosis and the Nervous System
160. Apoptosis in glomerular sclerosis
161. The CD95 Receptor: Apoptosis Revisited
162. Apoptosis and exercise
163. Radiation-induced Apoptosis
164. p53 and Apoptosis
165. A novel anti-Apoptosis gene, survivin, expressed in cancer and lymphoma
166. Ca2+-Induced Apoptosis Through Calcineurin Dephosphorylation of BAD
167. Cell cycle and Apoptosis
168. Mechanisms of chondrocyte Apoptosis
169. Cell Cycle and Apoptosis
170. VDAC2 Inhibits BAK Activation and Mitochondrial Apoptosis
171. Cell death: Apoptosis versus necrosis (Review)
172. Integrins, adhesion and Apoptosis
173. Apoptosis of T cells mediated by galectin-1
174. Glutathione and Apoptosis
175. Mediation of c-Myc-induced Apoptosis by p53
176. Apoptosis After Traumatic Brain Injury
177. Nitric oxide-mediated Apoptosis in murine peritoneal macrophages.
178. Sphingosine in Apoptosis signaling
179. Monoclonal antibody-mediated tumor regression by induction of Apoptosis
180. Apoptosis and APC in colorectal tumorigenesis
181. The Beclin 1 network regulates autophagy and Apoptosis
182. Tumor Necrosis Factor: An Apoptosis JuNKie?
183. The mitochondrion in Apoptosis: how Pandora’s box opens
184. Phagocytic docking without shocking
185. Mitochondrial control of Apoptosis: an introduction
186. Apoptosis in metanephric development.
187. p53 and E2F-1 cooperate to mediate Apoptosis
188. Host defense, viruses and Apoptosis
189. Apoptosis-and-the-Dilemma-of-Cancer-Chemotherapy”>Apoptosis and the Dilemma of Cancer Chemotherapy
190. Triggering and modulation of Apoptosis by oxidative stress
191. REGULATION OF CERAMIDE PRODUCTION AND Apoptosis
192. CELL CYCLE REGULATION AND Apoptosis1
193. Molecular control of neutrophil Apoptosis
194. miR-15 and miR-16 induce Apoptosis by targeting BCL2
195. Apoptosis, Excitotoxicity, and Neuropathology
196. Apoptosis in rheumatoid arthritis synovium.
197. The central executioners of Apoptosis: caspases or mitochondria?
198. Bax suppresses tumorigenesis and stimulates Apoptosis in vivo
199. Apoptosis (the 1992 Frank Rose Memorial Lecture)
200. Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics
201. p53 in neuronal Apoptosis
202. Placental Apoptosis in normal human pregnancy
203. Heat Shock Proteins Increase Resistance to Apoptosis
204. Ways of dying: multiple pathways to Apoptosis
205. Mitochondrial respiratory chain inhibitors induce Apoptosis
206. Mammalian Caspases: Structure, Activation, Substrates, and Functions During Apoptosis
207. Histochemical detection of Apoptosis in Parkinson’s disease
208. Apoptosis: a different type of cell death.
209. Bcl-2 functions in an antioxidant pathway to prevent Apoptosis
210. Regulation of cell death: the calcium–Apoptosis link
211. Fas Ligand-Induced Apoptosis as a Mechanism of Immune Privilege
212. The role of proteases during Apoptosis.
213. Evidence for Synaptic Apoptosis
214. Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis
215. The role of calcium in Apoptosis
216. Apoptosis in leukocytes
217. Apoptosis and brain ischaemia
218. The miR-34 family in cancer and Apoptosis
219. Keratocyte Apoptosis after corneal surgery.
220. Heat-shock protein 70 antagonizes Apoptosis-inducing factor
221. Anti-Apoptosis gene, survivin, and prognosis of neuroblastoma
222. Mitochondrial DNA Mutations, Oxidative Stress, and Apoptosis in Mammalian Aging
223. Apoptosis and hepatobiliary disease
224. Mechanisms underlying nonsteroidal antiinflammatory drug-mediated Apoptosis
225. Apoptosis and osteoporosis
226. Akt, FoxO and regulation of Apoptosis
227. An IAP-IAP Complex Inhibits Apoptosis
228. Acute Doxorubicin Cardiotoxicity Involves Cardiomyocyte Apoptosis
229. IAP proteins: blocking the road to death’s door
230. Multi-walled carbon nanotubes induce T lymphocyte Apoptosis
231. Apoptosis
232. TNF-Induced Signaling in Apoptosis
233. A Caspase-Related Protease Regulates Apoptosis in Yeast
234. TIGAR, a p53-Inducible Regulator of Glycolysis and Apoptosis
235. Apoptosis and liver disease
236. Regulation of Apoptosis by viral gene products.
237. Regulation of Apoptosis by endoplasmic reticulum pathways
238. Astrocyte Apoptosis: implications for neuroprotection
239. Calcium and Apoptosis: ER-mitochondria Ca2+ transfer in the control of Apoptosis
240. How cells die: Apoptosis pathways
241. Staurosporine-Induced Neuronal Apoptosis
242. PUMA Induces the Rapid Apoptosis of Colorectal Cancer Cells
243. Inhibition of Apoptosis during Development of Colorectal Cancer
244. Doxorubicin-induced Apoptosis: Implications in cardiotoxicity
245. lnterleukin-2 programs mouse αβ T lymphocytes for Apoptosis
246. Apoptosis‐inducing factor (AIF): a ubiquitous mitochondrial oxidoreductase involved in Apoptosis
247. Apoptosis Clinical Relevance and Pharmacological Manipulation
248. THE MITOCHONDRIAL DEATH/LIFE REGULATOR IN Apoptosis AND NECROSIS
249. Mechanisms of p53-mediated Apoptosis
250. Apoptosis and the cell cycle
251. Oxygen Stress: A Regulator of Apoptosis in Yeast
252. Morphologic criteria and detection of Apoptosis
253. Vitronectin receptor-mediated phagocytosis of cells undergoing Apoptosis
254. Intracellular unesterified arachidonic acid signals Apoptosis
255. Reactive oxygen species, mitochondria, Apoptosis and aging
256. p53- and ATM-Dependent Apoptosis Induced by Telomeres Lacking TRF2
257. Apoptosis and genomic instability
258. WAF1/CIP1 Is Induced in p53-mediated G1 Arrest and Apoptosis
259. Role of Apoptosis in disease
260. p53 expression in nitric oxide‐induced Apoptosis
261. Noncaspase proteases in Apoptosis
262. Apoptosis and the cell cycle
263. Degradation of chromosomal DNA during Apoptosis
264. Mitochondria as regulators of Apoptosis: doubt no more
265. Deadly encounter: ubiquitin meets Apoptosis
266. Apoptosis. Its nature and implications for dermatopathology.
267. Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced Apoptosis
268. Review: Nuclear Events in Apoptosis
269. Induction of gastric epithelial Apoptosis by Helicobacter pylori.
270. Analysis of Apoptosis by propidium iodide staining and flow cytometry
271. Programmed cell death: necrosis versus Apoptosis.
272. Radiation-induced Apoptosis: Relevance to radiotherapy
273. Induction of Apoptosis by the Bcl-2 homologue Bak
274. Apoptosis and cancer chemotherapy
275. Bcl-2 blocks p53-dependent Apoptosis.
276. Movement of Bax from the Cytosol to Mitochondria during Apoptosis
277. Lamin proteolysis facilitates nuclear events during Apoptosis.
278. Apoptosis_avoidance_in_cancer.14.aspx”>Mechanisms of Apoptosis avoidance in cancer
279. Bax-independent inhibition of Apoptosis by Bcl-XL
280. Mitochondrial Regulation of Apoptosis
281. Mechanisms of CD95 (APO-1/Fas)-mediated Apoptosis
282. Control of Apoptosis by the cellular ATP level
283. Cell Death by Apoptosis in Epidermal Biology
284. Mechanisms of TGF-β-mediated Apoptosis
285. Apoptosis-in-cancer”>Cellular stress response and Apoptosis in cancer therapy
286. C1q, Autoimmunity and Apoptosis
287. Mitochondrial photodamage and PDT-induced Apoptosis
288. Control of Apoptosis by Rel/NF-κB transcription factors
289. Sphingosine kinase, sphingosine-1-phosphate, and Apoptosis
290. Bcl-2 Phosphorylation Required for Anti-Apoptosis Function
291. Chronological aging leads to Apoptosis in yeast
292. Apoptosis and necrosis: Detection, discrimination and phagocytosis
293. TRAIL‐R2: a novel Apoptosis‐mediating receptor for TRAIL
294. Apoptosis and the cell cycle.
295. Apoptosis in neurodegenerative disorders.
296. Superoxide in Apoptosis MITOCHONDRIAL GENERATION TRIGGERED BY CYTOCHROMEc LOSS
297. Activation-induced Apoptosis in lymphocytes
298. Chromatin changes in Apoptosis
299. DNA fragmentation in Apoptosis
300. Proteolysis of Fodrin (Non-erythroid Spectrin) during Apoptosis
301. Caspase-12 mediates endoplasmic-reticulum-specific Apoptosis and cytotoxicity by amyloid-β
302. Apoptosis and neurologic disease
303. Calcium and Apoptosis: facts and hypotheses
304. INVOLVEMENT OF Apoptosis IN OVARIAN FOLLICULAR ATRESIA AND POSTOVULATORY REGRESSION
305. Apoptosis and glutathione: beyond an antioxidant
306. Integrating the mechanisms of Apoptosis induced by endoplasmic reticulum stress
307. Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked
308. TNF- and Cancer Therapy-Induced Apoptosis: Potentiation by Inhibition of NF-κB
309. p53-dependent Induction of Apoptosis by Proteasome Inhibitors
310. Lysosomal involvement in Apoptosis
311. Apoptosis Basic Mechanisms and Implications for Cardiovascular Disease
312. Induction of Apoptosis by the low-affinity NGF receptor
313. Molecular steps of death receptor and mitochondrial pathways of Apoptosis
314. Apoptosis in the Trophoblast—Role of Apoptosis in Placental Morphogenesis
315. Bcl-2-regulated Apoptosis: mechanism and therapeutic potential
316. Do all programmed cell deaths occur via Apoptosis?
317. Salmonella typhimurium invasion induces Apoptosis in infected macrophages
318. Cell Activation and Apoptosis by Bacterial Lipoproteins Through Toll-like Receptor-2
319. Mechanisms of Apoptosis by c-Myc
320. Apoptosis and acute kidney injury
321. c-Myc and Apoptosis
322. Apoptosis after traumatic human spinal cord injury
323. Signalling mechanisms and oxidative stress in Apoptosis
324. Apoptosis pathways in cancer and cancer therapy
325. Nitric Oxide Synthase Induces Macrophage Death by Apoptosis
326. Direct Activation of Bax by p53 Mediates Mitochondrial Membrane Permeabilization and Apoptosis
327. Cell biology. Apoptosis–the calcium connection
328. Control of mitochondrial Apoptosis by the Bcl-2 family
329. p62 at the Crossroads of Autophagy, Apoptosis, and Cancer
330. Livin, a Novel Inhibitor of Apoptosis Protein Family Member
331. Ceramide in Apoptosis: an overview and current perspectives
332. Apoptosis induced by bacterial pathogens.
333. Microtubule-targeted anticancer agents and Apoptosis
334. FOXOs, cancer and regulation of Apoptosis
335. The proto-oncogene Bcl-2 and its role in regulating Apoptosis
336. Involvement of an ICE-like protease in Fas-mediated Apoptosis
337. Programmed cell death, Apoptosis and killer genes
338. TRAIL-induced signalling and Apoptosis
339. Apoptosis: The importance of being eaten
340. Senescence, Apoptosis or Autophagy?
341. Apoptosis and cancer: mutations within caspase genes
342. Promoting Apoptosis as a strategy for cancer drug discovery
343. Apoptosis-based-therapies-for-hematologic”>Apoptosis-based therapies for hematologic malignancies
344. Haemopoietic colony stimulating factors promote cell survival by suppressing Apoptosis
345. The role of intracellular oxidants in Apoptosis
346. Mitochondrial permeability transition is a central coordinating event of Apoptosis.
347. Neuronal and Glial Apoptosis after Traumatic Spinal Cord Injury
348. Antibody-induced Apoptosis
349. Bcl-2 family proteins: regulators of Apoptosis and chemoresistance in hematologic malignancies.
350. Signalling Apoptosis: a radical approach
351. Apoptosis_in_rheumatoid_arthritis.15.aspx”>Apoptosis in rheumatoid arthritis
352. Cell proliferation and Apoptosis
353. Bcl-2 blocks Apoptosis in cells lacking mitochondrial DNA
354. Apoptosis induction resulting from proteasome inhibition.
355. mir-29 regulates Mcl-1 protein expression and Apoptosis
356. The role of Apoptosis in wound healing
357. Induction of Apoptosis in mature T cells by tumour necrosis factor
358. Apoptosis: mechanisms and relevance in cancer
359. Keratocyte Apoptosis Associated with Keratoconus
360. Apoptosis Target of Cancer Therapy
361. Requirement for ERK Activation in Cisplatin-induced Apoptosis
362. Inactivation of the Apoptosis effector Apaf-1 in malignant melanoma
363. Intracellular ATP Levels Determine Cell Death Fate by Apoptosis or Necrosis
364. Liver Apoptosis
365. Apoptosis detection: an overview
366. Bid-deficient mice are resistant to Fas-induced hepatocellular Apoptosis
367. Caspases 3 and 7: Key Mediators of Mitochondrial Events of Apoptosis
368. Cleavage of CAD inhibitor in CAD activation and DNA degradation during Apoptosis
369. Activation of p34cdc2 coincident with taxol-induced Apoptosis.
370. IAP Antagonists Target cIAP1 to Induce TNFα-Dependent Apoptosis
371. Apoptosis and autophagy in nigral neurons of patients with Parkinson’s disease
372. Role of Apoptosis in reperfusion injury
373. Decreased Apoptosis in the brain and premature lethality in CPP32-deficient mice
374. Apoptosis induced by a human milk protein
375. PROTEOLYTIC ACTIVITIES THAT MEDIATE Apoptosis
376. p53-Dependent Apoptosis suppresses tumor growth and progression in vivo
377. Apoptosis and carcinogenesis.
378. Requirement for Caspase-2 in Stress-Induced Apoptosis Before Mitochondrial Permeabilization
379. Increased placental Apoptosis in pregnancies complicated by preeclampsia
380. Rb function in cell-cycle regulation and Apoptosis
381. Rapamycin pre-treatment protects against Apoptosis
382. Increased placental Apoptosis in intrauterine growth restriction
383. Nitric Oxide Inhibits Fas-induced Apoptosis
384. TRAIL and Apoptosis induction by TNF-family death receptors
385. Erythropoietin prevents neuronal Apoptosis after cerebral ischemia and metabolic stress
386. Viral FLICE-inhibitory proteins (FLIPs) prevent Apoptosis induced by death receptors
387. Apoptosis in rotator cuff tendonopathy
388. Macrophage Apoptosis in mycobacterial infections
389. Transcriptional Activation of miR-34a Contributes to p53-Mediated Apoptosis
390. Why Target Apoptosis in Cancer Treatment?
391. Apoptosis-inducing and Apoptosis-preventing functions of poliovirus.
392. Survivin, versatile modulation of cell division and Apoptosis in cancer
393. Tumoricidal activity of tumor necrosis factor–related Apoptosis–inducing ligand in vivo
394. Modulation of Apoptosis by the widely distributed Bcl-2 homologue Bak
395. Endothelial Apoptosis in Braf-deficient mice
396. Review: The role of glutathione in the regulation of Apoptosis.
397. From bench to clinic with Apoptosis-based therapeutic agents
398. Apoptosis in Viral Infections
399. TRAIL receptor-2 signals Apoptosis through FADD and caspase-8
400. Triggering of Apoptosis by cathepsins
401. Apoptosis in the human embryo
402. ER Stress Triggers Apoptosis by Activating BH3-Only Protein Bim
403. Ageing and Apoptosis
404. Apoptosis, p53, and Tumor Cell Sensitivity to Anticancer Agents
405. Subcellular location prediction of Apoptosis proteins
406. Activation of Apoptosis in Vivo by a Hydrocarbon-Stapled BH3 Helix
407. Oxidized low-density lipoprotein-induced Apoptosis
408. Control of TRAIL-Induced Apoptosis by a Family of Signaling and Decoy Receptors
409. A cautionary note on the use of the TUNEL stain to determine Apoptosis.
410. Inhibition of VEGF receptors causes lung cell Apoptosis and emphysema
411. Apoptosis and cancer chemotherapy
412. Apoptosis in yeast: triggers, pathways, subroutines
413. Nitric oxide and its role in Apoptosis
414. Evidence of Apoptosis in Arrhythmogenic Right Ventricular Dysplasia
415. Apoptosis in Irradiated Murine Tumors
416. Identification and inhibition of the ICE/CED-3 protease necessary for mammalian Apoptosis
417. Regulation of Apoptosis by Bcl‐2 family proteins
418. Caspase Pathways, Neuronal Apoptosis, and CNS Injury
419. Estrogen promotes Apoptosis of murine osteoclasts mediated by TGF–β
420. Suppression of ICE and Apoptosis in mammary epithelial cells by extracellular matrix
421. Is Cisplatin-Induced Cell Death Always Produced by Apoptosis?
422. The Apoptosis endonuclease and its regulation.
423. Pathways to neuronal injury and Apoptosis in HIV-associated dementia
424. Cell death by Apoptosis and its protective role against disease
425. Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis
426. Apoptosis and chemotherapy resistance
427. Viral Control of Mitochondrial Apoptosis
428. Cytosol-to-membrane redistribution of Bax and Bcl-XL during Apoptosis
429. c-Myc Target Genes Involved in Cell Growth, Apoptosis, and Metabolism
430. Induction of TNF Receptor I-Mediated Apoptosis via Two Sequential Signaling Complexes
431. Interleukin-6 Delays Neutrophil Apoptosis
432. Heat-shock proteins as regulators of Apoptosis
433. Nitric oxide induces Apoptosis in mouse thymocytes.
434. Oocyte Apoptosis: Like Sand through an Hourglass
435. p53-dependent pathways of Apoptosis
436. Structure of Bcl-xL-Bak Peptide Complex: Recognition Between Regulators of Apoptosis
437. Apoptosis and necrosis. Basic types and mechanisms of cell death.
438. An Apoptosis-inhibiting baculovirus gene with a zinc finger-like motif.
439. Apoptosis in Autoimmune Diseases
440. Apoptosis is induced by beta-amyloid in cultured central nervous system neurons
441. Microglia Shape Adult Hippocampal Neurogenesis through Apoptosis-Coupled Phagocytosis
442. Mitochondrial fission in Apoptosis, neurodegeneration and aging
443. Dormancy of micrometastases: Balanced proliferation and Apoptosis in the presence of angiogenesis suppression
444. Mitochondria in Apoptosis: Bcl-2 Family Members and Mitochondrial Dynamics
445. The harlequin mouse mutation downregulates Apoptosis-inducing factor
446. Human chondrocyte Apoptosis in response to mechanical injury
447. Targeting the extrinsic Apoptosis pathway in cancer
448. Interleukin 1 is processed and released during Apoptosis
449. Myocyte Apoptosis in heart failure
450. Caspase-3-Generated Fragment of Gelsolin: Effector of Morphological Change in Apoptosis
451. Apoptosis-inducing factor: vital and lethal
452. Neurotrophin signalling pathways regulating neuronal Apoptosis
453. Noninvasive real-time imaging of Apoptosis
454. Mitochondrial survivin inhibits Apoptosis and promotes tumorigenesis
455. Apoptosis and cancer: the genesis of a research field
456. Mitochondrial control of Apoptosis: the role of cytochrome c
457. The p53 pathway and Apoptosis
458. An AIF orthologue regulates Apoptosis in yeast
459. Apoptosis/”>The Role of p53 in Apoptosis
460. The role of Apoptosis in cancer development and treatment response
461. Serial killers: ordering caspase activation events in Apoptosis
462. Shear stress inhibits Apoptosis of human endothelial cells
463. CD28 and Apoptosis
464. Apoptosis: definition, mechanisms, and relevance to disease
465. Does nitric oxide modulate mitochondrial energy generation and Apoptosis?
466. Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates Apoptosis
467. Chemotherapy Augments TRAIL-induced Apoptosis in Breast Cell Lines
468. Functions of gelsolin: motility, signaling, Apoptosis, cancer
469. A caspase-activated DNase that degrades DNA during Apoptosis, and its inhibitor ICAD
470. Role of HIF-1α in hypoxia-mediated Apoptosis, cell proliferation and tumour angiogenesis
471. p73 is a human p53-related protein that can induce Apoptosis
472. PKR, Apoptosis and cancer
473. Nuclear factor-κB, cancer, and Apoptosis
474. Molecular mechanisms of UV‐induced Apoptosis
475. Metals and Apoptosis: Recent developments
476. miRNAs and Apoptosis: RNAs to die for
477. Mitochondrial permeability transition: a common pathway to necrosis and Apoptosis
478. Akt is more than just a Bad kinase
479. Apoptosis in skeletal muscle with aging
480. Apoptosis and cancer drug targeting
481. Glucocorticoid-induced Apoptosis in the thymus.
482. Intracellular redox changes during Apoptosis.
483. Apoptosis and delayed degeneration after spinal cord injury in rats and monkeys
484. Possible mechanisms of paclitaxel-induced Apoptosis.
485. Apoptosis in atherosclerosis: beneficial or detrimental?
486. Role of Gadd45 in Apoptosis
487. p53 in signaling checkpoint arrest or Apoptosis
488. Cell death: a new classification separating Apoptosis from necrosis
489. Chelation of intracellular zinc triggers Apoptosis in mature thymocytes.
490. E2F1 pathways to Apoptosis
491. Granzymes: exogenous porteinases that induce target cell Apoptosis
492. The role of mitochondria in Apoptosis.
493. Chemotherapy-Induced Apoptosis
494. The Role of Calcium in the Regulation of Apoptosis
495. Apoptosis: The Biochemistry and Molecular Biology of Programmed Cell Death
496. P53, cell cycle control and Apoptosis: Implications for cancer
497. Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing Apoptosis
498. twist is a potential oncogene that inhibits Apoptosis
499. Mitochondria, oxygen free radicals, and Apoptosis
500. Complement and Apoptosis
501. The Mitochondrial Death Pathway and Cardiac Myocyte Apoptosis
502. The transcriptional targets of p53 in Apoptosis control
503. Integrin αvβ3 antagonists promote tumor regression by inducing Apoptosis of angiogenic blood vessels
504. Apoptosis“>Mechanisms of HIV-associated lymphocyte Apoptosis
505. Apoptosis and melanoma: molecular mechanisms
506. Apoptosis-of-human”>Glucocorticoids inhibit Apoptosis of human neutrophils
507. JNK-Mediated BIM Phosphorylation Potentiates BAX-Dependent Apoptosis
508. Apoptosis and caspases regulate death and inflammation in sepsis
509. Nitric Oxide as a Bifunctional Regulator of Apoptosis
510. Recognition and phagocytosis of cells undergoing Apoptosis
511. Inhibition of Apoptosis by Survivin Predicts Shorter Survival Rates in Colorectal Cancer
512. Apoptosis during luteal regression in cattle
513. Osteoarthritis chondrocytes die by Apoptosis: A possible pathway for osteoarthritis pathology
514. Induction of a Common Pathway of Apoptosis by Staurosporine
515. Cell Surface Trafficking of Fas: A Rapid Mechanism of p53-Mediated Apoptosis
516. Apoptosis in the ovary: molecular mechanisms
517. FLICE-Inhibitory Proteins: Regulators of Death Receptor-Mediated Apoptosis
518. Reactive oxygen species are downstream mediators of p53-dependent Apoptosis
519. Cytoskeleton and Apoptosis
520. Apoptosis induced by death receptors
521. Neuroprotection by the Inhibition of Apoptosis
522. Ceramide signaling in Apoptosis
523. Apoptosis in cell culture
524. Peroxynitrite-induced Apoptosis in HL-60 Cells
525. Cytochemical Methods for the Detection of Apoptosis
526. Apoptosis: an innate immune response to virus infection
527. Expression of galectin-3 modulates T-cell growth and Apoptosis
528. Glaucoma, Apoptosis, and neuroprotection.
529. Methylmercury-induced neurotoxicity and Apoptosis
530. Life in the balance: how BH3-only proteins induce Apoptosis
531. Regulation of Apoptosis in the immune system
532. Human Dendritic Cells Mediate Cellular Apoptosis via Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand (Trail)
533. Screening and Detection of Apoptosis
534. Apoptosis in podocytes induced by TGF-β and Smad7
535. Intracellular Regulation of TRAIL-Induced Apoptosis in Human Melanoma Cells
536. Prevention of osteocyte and osteoblast Apoptosis by bisphosphonates and calcitonin
537. Caspase-3 Is Required for DNA Fragmentation and Morphological Changes Associated with Apoptosis
538. Inducible Apoptosis as a Safety Switch for Adoptive Cell Therapy
539. Estrogens inhibit and androgens enhance ovarian granulosa cell Apoptosis
540. Cadmium-Induced Apoptosis in Mouse Liver
541. Apoptosis in Myocardial Ischemia‐Reperfusion
542. The inhibitors of Apoptosis (IAPs) and their emerging role in cancer
543. Apoptosis in human ejaculated sperm cells (notulae seminologicae 9).
544. Induction of Apoptosis–new targets for cancer chemotherapy.
545. The Mitochondrial Pathways of Apoptosis
546. Activation-induced cell death (Apoptosis) of mature peripheral T lymphocytes
547. No PUMA, no death: Implications for p53-dependent Apoptosis
548. Apoptosis of Neutrophils
549. Apoptosis and Molecular Targeting Therapy in Cancer
550. The Mitochondrion: Is It Central to Apoptosis?
551. Essential role of the mitochondrial Apoptosis-inducing factor in programmed cell death
552. Bisphosphonates promote Apoptosis in murine osteoclasts in vitro and in vivo
553. Morphine Enhances Macrophage Apoptosis
554. Cardiomyocyte Apoptosis and progression of heart failure to transplantation.
555. Genetic determinants of p53-induced Apoptosis and growth arrest.
556. Mechanisms of resistance to TRAIL-induced Apoptosis in cancer
557. Apaf1 Is Required for Mitochondrial Pathways of Apoptosis and Brain Development
558. Increased islet Apoptosis in Pdx1+/– mice
559. The Role of STATs in Apoptosis
560. Phosphorylation of Bcl2 and regulation of Apoptosis
561. Intracellular Adenosine Triphosphate (ATP) Concentration: A Switch in the Decision Between Apoptosis and Necrosis
562. MicroRNA and cancer – focus on Apoptosis
563. P53- and CD95-associated Apoptosis in neurodegenerative diseases.
564. Physiology of Apoptosis
565. Apoptosis: The nexus of liver injury and fibrosis
566. Evading Apoptosis in cancer
567. Fas-Mediated Apoptosis
568. Mechanisms underlying hypoxia-induced neuronal Apoptosis
569. Human cytomegalovirus IE1 and IE2 proteins block Apoptosis.
570. Increased bone formation by prevention of osteoblast Apoptosis with parathyroid hormone
571. Hierarchical regulation of mitochondrion-dependent Apoptosis by BCL-2 subfamilies
572. Mitochondrial mechanisms of neural cell Apoptosis
573. Mitochondrial Ca2+ and Apoptosis
574. A mechanistic role for cardiac myocyte Apoptosis in heart failure
575. Bax and Adenine Nucleotide Translocator Cooperate in the Mitochondrial Control of Apoptosis
576. Resistance to Apoptosis Conferred by Cdk Inhibitors During Myocyte Differentiation
577. Macrophage Apoptosis by Anthrax Lethal Factor Through p38 MAP Kinase Inhibition
578. The Induction of Apoptosis by Bacterial Pathogens
579. Humanin peptide suppresses Apoptosis by interfering with Bax activation
580. The function of PML in p53-dependent Apoptosis
581. Role of JNK activation in Apoptosis: A double-edged sword
582. Internucleosomal DNA Cleavage Should not be the Sole Criterion for Identifying Apoptosis
583. Induction by antigen of intrathymic Apoptosis of CD4+CD8+TCRlo thymocytes in vivo
584. Regulation and measurement of oxidative stress in Apoptosis
585. Carbon Monoxide Generated by Heme Oxygenase 1 Suppresses Endothelial Cell Apoptosis
586. Implication of mitochondria in Apoptosis
587. Cell cycle checkpoint signaling:: Cell cycle arrest versus Apoptosis
588. Sphingosine kinases, sphingosine 1-phosphate, Apoptosis and diseases
589. Apoptosis: Suicide,execution or murder?
590. Purines and their roles in Apoptosis
591. A simple technique for quantifying Apoptosis in 96-well plates
592. Virulent Mycobacterium tuberculosis Strains Evade Apoptosis of Infected Alveolar Macrophages
593. Mediation of Neuronal Apoptosis by Enhancement of Outward Potassium Current
594. Identification and characterization of a new member of the TNF family that induces Apoptosis
595. Infection by Mycobacterium tuberculosis promotes human alveolar macrophage Apoptosis.
596. Environmental enrichment inhibits spontaneous Apoptosis, prevents seizures and is neuroprotective
597. A death-domain-containing receptor that mediates Apoptosis
598. β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes
599. Wild-type p53 induces Apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6
600. Apoptosis as a Novel Target for Cancer Chemoprevention
601. Bcl-2 family members: Dual regulators of Apoptosis and autophagy
602. Signals leading to Apoptosis-dependent inhibition of neovascularization by thrombospondin-1
603. Apoptosis in Neural Development and Disease
604. Daxx, a Novel Fas-Binding Protein That Activates JNK and Apoptosis
605. Delayed eosinophil Apoptosis in asthma
606. Evidence that 4-Hydroxynonenal Mediates Oxidative Stress-Induced Neuronal Apoptosis
607. Apoptosis in Neurological Disease
608. Rho signals to cell growth and Apoptosis
609. Linkage of chondrocyte Apoptosis and cartilage degradation in human osteoarthritis
610. Akt Phosphorylates and Negatively Regulates Apoptosis Signal-Regulating Kinase 1
611. The biochemistry of cell death by Apoptosis
612. Apoptosis_and_cardiomyopathy.11.aspx”>Apoptosis and cardiomyopathy
613. Apoptosis and brain development
614. Endothelial Cell Apoptosis in Angiogenesis and Vessel Regression
615. High-Glucose–Triggered Apoptosis in Cultured Endothelial Cells
616. Apoptosis: Identification of dying cells
617. Transactivation of miR-34a by p53 Broadly Influences Gene Expression and Promotes Apoptosis
618. Histone Deacetylase Inhibitors: Inducers of Differentiation or Apoptosis of Transformed Cells
619. Ions, cell volume, and Apoptosis
620. BAX and BAK Regulation of Endoplasmic Reticulum Ca2+: A Control Point for Apoptosis
621. Caspases find a new place to hide
622. Proinflammatory Cytokines Disrupt Epithelial Barrier Function by Apoptosis-Independent Mechanisms
623. Apoptosis and the liver
624. Angiopoietin-1 Inhibits Endothelial Cell Apoptosis via the Akt/Survivin Pathway
625. T Cell Apoptosis by Kynurenines
626. Inhibition of Apoptosis induced by ischemia-reperfusion prevents inflammation
627. Apoptosis and autoimmunity
628. Hepatocyte Apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis
629. Biochemical determinants of Apoptosis and necrosis
630. Autoimmune disease. a problem of defective Apoptosis
631. Apoptosis in progressive crescentic glomerulonephritis.
632. Apoptosis, Pyroptosis, and Necrosis: Mechanistic Description of Dead and Dying Eukaryotic Cells
633. The IGF-I receptor in cell growth, transformation and Apoptosis
634. The dark side of Ras: regulation of Apoptosis
635. Apoptosis-regulating proteins as targets for drug discovery
636. Apoptosis induced by cisplatin nephrotoxic injury
637. Macrophage recognition of cells undergoing programmed cell death (Apoptosis).
638. The Role of c-FLIP in Modulation of CD95-induced Apoptosis
639. NADH Oxidase Activity of Mitochondrial Apoptosis-inducing Factor
640. NODs: intracellular proteins involved in inflammation and Apoptosis
641. Epilepsy and Apoptosis Pathways
642. Sphingomyelin hydrolysis during Apoptosis
643. Apoptosis versus oncotic necrosis in hepatic ischemia/reperfusion injury
644. Apoptosis driven by IP3‐linked mitochondrial calcium signals
645. A Yeast Mutant Showing Diagnostic Markers of Early and Late Apoptosis
646. Apoptosis in adult retinal ganglion cells after axotomy
647. Nitric oxide (NO): an effector of Apoptosis
648. Glucagon-like Peptide-1 Receptor Signaling Modulates β Cell Apoptosis
649. Induction of Apoptosis and Inhibition of Cell Proliferation bysurvivin Gene Targeting
650. Control of Apoptosis during Angiogenesis by Survivin Expression in Endothelial Cells
651. Clusterin inhibits Apoptosis by interacting with activated Bax
652. Regulation of death receptor-mediated Apoptosis pathways
653. Autophagy and Apoptosis: what is the connection?
654. Caspase‐activation pathways in Apoptosis and immunity
655. Induction of Apoptosis in uninfected lymphocytes by HIV-1 Tat protein
656. Telomere shortening and Apoptosis in telomerase-inhibited human tumor cells
657. Alterations in cellular adhesion and Apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2
658. Mitochondrial permeability transition triggers lymphocyte Apoptosis.
659. Role of Mitochondria in Apoptosis
660. The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis
661. Artemisinin Induces Apoptosis in Human Cancer Cells
662. Calcium-mediated Apoptosis in a plant hypersensitive disease resistance response
663. Protection from Fas-mediated Apoptosis by a soluble form of the Fas molecule
664. Reduced Apoptosis and Cytochrome c–Mediated Caspase Activation in Mice Lacking Caspase 9
665. Loss of the cylindromatosis tumour suppressor inhibits Apoptosis by activating NF-κB
666. beta-cell Apoptosis: stimuli and signaling.
667. CYTOKINE-MEDIATED NEURONAL Apoptosis
668. Apoptosis and Thyroiditis
669. A structural view of mitochondria-mediated Apoptosis
670. Phospolipase A2 and Apoptosis
671. Apoptosis-by-BCR-ABL-in-chronic”>Inhibition of Apoptosis by BCR-ABL in chronic myeloid leukemia
672. The Pathways of Cell Death: Oncosis, Apoptosis, and Necrosis
673. Cell death in health and disease: the biology and regulation of Apoptosis
674. Calpains, mitochondria, and Apoptosis
675. Apoptosis in the vasculature: mechanisms and functional importance
676. Photodynamic therapy: A mitochondrial inducer of Apoptosis
677. Requirement for BMP Signaling in Interdigital Apoptosis and Scale Formation
678. Survivin and Apoptosis control
679. BH3-only proteins: Orchestrators of Apoptosis
680. A Bad kinase makes good
681. Neurotransmitters and Apoptosis in the developing brain
682. Lipopolysaccharide Induces Disseminated Endothelial Apoptosis Requiring Ceramide Generation
683. Interleukin-15 protects from lethal Apoptosis in vivo
684. Regulation of Apoptosis at cell division by p34cdc2 phosphorylation of survivin
685. A single chicken anemia virus protein induces Apoptosis.
686. Apoptosis, autophagy, necroptosis, and cancer metastasis
687. Regulation of Apoptosis in Drosophila
688. Wild-type p53 mediates Apoptosis by E1A, which is inhibited by E1B.
689. Defects in regulation of Apoptosis in caspase-2-deficient mice
690. Membrane blebbing during Apoptosis results from caspase-mediated activation of ROCK I
691. Role for the p53 homologue p73 in E2F-1-induced Apoptosis
692. Neutrophil Apoptosis in the Acute Respiratory Distress Syndrome
693. Apoptosis and the kidney.
694. Chromatin cleavage in Apoptosis: Association with condensed chromatin morphology and dependence on macromolecular synthesis
695. Altered cytokine export and Apoptosis in mice deficient in interleukin-1 beta converting enzyme
696. RGD peptides induce Apoptosis by direct caspase-3 activation
697. Apoptosis in myocardial ischaemia and infarction
698. If not Apoptosis, then what? Treatment-induced senescence and mitotic catastrophe in tumor cells
699. Angiotensin II Induces Apoptosis of Adult Ventricular MyocytesIn Vitro
700. The CD95 (APO-1/Fas) and the TRAIL (APO-2L) Apoptosis Systems
701. Detection of Apoptosis in tissue sections
702. Apoptosis and Emphysema The Missing Link
703. p53-Dependent Apoptosis in the absence of transcriptional activation of p53-target genes
704. Apoptosis and Apoptosis related gene expression in normal conjunctiva and pterygium
705. Apoptosis and its role in the trophoblast
706. Abortive Apoptosis in Alzheimer’s disease
707. Apoptosis during wound healing, fibrocontractive diseases and vascular wall injury
708. Apoptosis in pressure overload-induced heart hypertrophy in the rat.
709. Signal transduction pathways to Apoptosis
710. Apoptosis Initiated When BH3 Ligands Engage Multiple Bcl-2 Homologs, Not Bax or Bak
711. Caspases: their intracellular localization and translocation during Apoptosis
712. Cellular Oxygen Toxicity OXIDANT INJURY WITHOUT Apoptosis
713. Apoptosis and oxidants in the heart
714. Apoptosis in the aging process
715. Sphingosine-induced Apoptosis is dependent on lysosomal proteases.
716. c‐Myc‐induced Apoptosis in fibroblasts is inhibited by specific cytokines.
717. Apoptosis in human endometrium and endometriosis
718. Apaf-1 and Caspase-9 in p53-Dependent Apoptosis and Tumor Inhibition
719. DAP kinase links the control of Apoptosis to metastasis
720. Requirement for phosphatidylinositol-3 kinase in the prevention of Apoptosis by nerve growth factor
721. Dicing with death: dissecting the components of the Apoptosis machinery
722. Nitric oxide: NO Apoptosis or turning it ON?
723. Why are mitochondria involved in Apoptosis? Permeability transition pores and Apoptosis as selective mechanisms to eliminate superoxide‐producing mitochondria and cell
724. Reactive oxygen species and yeast Apoptosis
725. Probiotic Bacterium Prevents Cytokine-induced Apoptosis in Intestinal Epithelial Cells
726. Inhibitor of Apoptosis proteins and Apoptosis
727. Apoptosis and Alzheimer’s disease
728. Oxidative Stress: Apoptosis in Neuronal Injury
729. Immune escape of tumors: Apoptosis resistance and tumor counterattack
730. Topoisomerase II-reactive Chemotherapeutic Drugs Induce Apoptosis in Thymocytes
731. Inhibition of Apoptosis and prolongation of neutrophil functional longevity by inflammatory mediators
732. The Apoptosis/autophagy paradox: autophagic vacuolization before apoptotic death
733. Role of HMGB1 in Apoptosis-mediated sepsis lethality
734. Myocardial Apoptosis and ischemic preconditioning
735. Macrophage Apoptosis in Tuberculosis
736. Role of reactive oxygen species in Apoptosis: implications for cancer therapy
737. Bisphosphonates induce Apoptosis in human breast cancer cell lines
738. Connected to Death: The (Unexpurgated) Mitochondrial Pathway of Apoptosis
739. Hsp60 Regulation of Tumor Cell Apoptosis
740. NFkappaB prevents Apoptosis and liver dysfunction during liver regeneration.
741. Cell cycle and Apoptosis: Common pathways to life and death
742. Pathways of Apoptosis in Lymphocyte Development, Homeostasis, and Disease
743. Apoptosis“>Protein kinase Cδ and Apoptosis
744. Apoptosis: biochemical aspects and clinical implications
745. Apoptosis and cancer mechanisms.
746. HSP27 and HSP70: Potentially Oncogenic Apoptosis Inhibitors
747. Colon cancer and Apoptosis
748. ASK1 is required for sustained activations of JNK/p38 MAP kinases and Apoptosis
749. Apoptosis without caspases: an inefficient molecular guillotine?
750. Cell nucleus and DNA fragmentation are not required for Apoptosis.
751. Granulocyte Apoptosis and the control of inflammation
752. Dominant interfering fas gene mutations impair Apoptosis in a human autoimmune lymphoproliferative syndrome
753. Lysosomal destabilization in p53-induced Apoptosis
754. Mechanisms and consequences of macrophage Apoptosis in atherosclerosis
755. Major DNA Fragmentation Is a Late Event in Apoptosis
756. Apo2L/TRAIL: Apoptosis signaling, biology, and potential for cancer therapy
757. Relationship of Mitotic Arrest and Apoptosis to Antitumor Effect of Paclitaxel
758. The Central Executioner of Apoptosis: Multiple Connections between Protease Activation and Mitochondria in Fas/APO-1/CD95- and Ceramide-induced Apoptosis
759. Cell death: programmed, Apoptosis, necrosis, or other?
760. Palmitate-induced Apoptosis Can Occur through a Ceramide-independent Pathway
761. PARP is important for genomic stability but dispensable in Apoptosis
762. Intracellular K+ Suppresses the Activation of Apoptosis in Lymphocytes
763. Tumor Radiosensitivity and Apoptosis
764. bcl-2 inhibits multiple forms of Apoptosis but not negative selection in thymocytes
765. Comet assay and early Apoptosis
766. Key morphological features of Apoptosis may occur in the absence of internucleosomal DNA fragmentation.
767. Apoptosis and tumourigenesis
768. A biochemical hallmark of Apoptosis: Internucleosomal degradation of the genome
769. Mediation of Poly(ADP-Ribose) Polymerase-1-Dependent Cell Death by Apoptosis-Inducing Factor
770. Growth Factor Regulation of Autophagy and Cell Survival in the Absence of Apoptosis
771. Dynamics of mitochondrial morphology in healthy cells and during Apoptosis
772. Apoptosis and Its Role in Human Disease
773. Down-Regulation of X-linked Inhibitor of Apoptosis Protein Induces Apoptosis in Chemoresistant Human Ovarian Cancer Cells
774. Neoadjuvant Trastuzumab Induces Apoptosis in Primary Breast Cancers
775. Apoptosis inhibitory activity of cytoplasmic p21Cip1/WAF1 in monocytic differentiation
776. Distinct Caspase Cascades Are Initiated in Receptor-mediated and Chemical-induced Apoptosis
777. Apoptosis in the development and maintenance of the immune system
778. Osteocyte Apoptosis
779. The control of Apoptosis in mammalian cells
780. Bcl-2 oncoprotein blocks chemotherapy-induced Apoptosis in a human leukemia cell line
781. Bcl-2-family proteins and the role of mitochondria in Apoptosis
782. Apoptosis Induced by Topoisomerase Inhibitors
783. Ionizing radiation acts on cellular membranes to generate ceramide and initiate Apoptosis.
784. Inhibitor of Apoptosis Proteins: Translating Basic Knowledge into Clinical Practice
785. Sensitization of T cells to CD95-mediated Apoptosis by HIV-1 Tat and gp120
786. Morphological assessment of Apoptosis
787. Reactive Oxygen Species Regulate Activation-Induced T Cell Apoptosis
788. Induction of Apoptosis as well as Necrosis by Hypoxia and Predominant Prevention of Apoptosis by Bcl-2 and Bcl-X
789. Sirtuin regulation of mitochondria: energy production, Apoptosis, and signaling
790. Mitochondrial OPA1, Apoptosis, and heart failure
791. Proteasomes play an essential role in thymocyte Apoptosis
792. Viruses and Apoptosis
793. Requirement of an ICE/CED-3 protease for Fas/APO-1-mediated Apoptosis
794. Glucocorticoids in T cell Apoptosis and function
795. Distinct BH3 domains either sensitize or activate mitochondrial Apoptosis, serving as prototype cancer therapeutics
796. Galectins in cell growth and Apoptosis
797. Bcl-2-family proteins: the role of the BH3 domain in Apoptosis
798. Apoptosis in cancer: cause and cure
799. Regulation of proliferation, survival and Apoptosis by members of the TNF superfamily
800. Myc signaling via the ARF tumor suppressor regulates p53-dependent Apoptosis and immortalization
801. To kill or be killed: viral evasion of Apoptosis
802. Apoptosis in disease
803. In vivo induction of Apoptosis by influenza virus
804. Inhibition of pp125FAK in cultured fibroblasts results in Apoptosis.
805. Non-genetic origins of cell-to-cell variability in TRAIL-induced Apoptosis
806. Involvement of the TIP60 Histone Acetylase Complex in DNA Repair and Apoptosis
807. Heat shock proteins: essential proteins for Apoptosis regulation
808. Biochemical Mechanisms of IL-2–Regulated Fas-Mediated T Cell Apoptosis
809. Caenorhabditis elegans p53: Role in Apoptosis, Meiosis, and Stress Resistance
810. Bcl-2 Inhibits Chemotherapy-induced Apoptosis in Neuroblastoma
811. Retinal ganglion cell death in experimental glaucoma and after axotomy occurs by Apoptosis.
812. Dexamethasone-induced Apoptosis involves cleavage of DNA to large fragments prior to internucleosomal fragmentation.
813. Apoptosis regulators and their role in tumorigenesis
814. Neutrophil Apoptosis pathways and their modifications in inflammation
815. Apoptosis and Heart Failure
816. Apoptosis induced by inhibition of intercellular contact.
817. Stress management – heat shock protein-70 and the regulation of Apoptosis
818. Fluorometric and Colorimetric Detection of Caspase Activity Associated with Apoptosis
819. Role of Poly(ADP-ribose) Polymerase (PARP) Cleavage in Apoptosis
     CASPASE 3-RESISTANT PARP MUTANT INCREASES RATES OF Apoptosis IN TRANSFECTED CELLS
820. CD95 Ligand (Fas-L/APO-1L) and Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Mediate Ischemia-Induced Apoptosis in Neurons
821. Apoptosis mediates the decrease in cellularity during the transition between granulation tissue and scar.
822. Programmed cell death and Apoptosis: origins of the theory
823. Protein kinase C involvement in Apoptosis
824. Apoptosis“>Caspase activation cascades in Apoptosis
825. Apoptosis-based therapies and drug targets
826. Life and death partners: Apoptosis, autophagy and the cross-talk between them
827. Is Apoptosis Key in Alzheimer’s Disease?
828. STRESS signaling pathways that modulate cardiac myocyte Apoptosis
829. Inhibition of Neuroepithelial Patched-Induced Apoptosis by Sonic Hedgehog
830. Induction of bax by genotoxic stress in human cells correlates with normal p53 status and Apoptosis.
831. Tributyltin stimulates Apoptosis in rat thymocytes
832. Apoptosis-an-overview”>Mitochondrial control of Apoptosis: an overview
833. Free radicals, exercise, Apoptosis, and heat shock proteins.
834. Role of Apoptosis in Sarcopenia
835. Stress-induced Apoptosis and the sphingomyelin pathway
836. Histopathological Evaluation of Apoptosis in Cancer
837. MEK Inhibition Enhances Paclitaxel-induced Tumor Apoptosis
838. Apoptosis in Parkinson’s disease: Signals for neuronal degradation
839. Apoptosis participates in cellularity regulation during rat aortic intimal thickening.
840. Interleukin-6 Inhibits Apoptosis of Malignant Plasma Cells
841. The pharmacology of Apoptosis
842. Dysregulated Expression of Neutrophil Apoptosis in the Systemic Inflammatory Response Syndrome
843. Apoptosis in the germ line
844. Apoptosis/links/5ce51080458515712eba7c04/Circulating-nucleic-acids-and-Apoptosis.pdf”>Circulating Nucleic Acids and Apoptosis
845. Tyrosine dephosphorylation of H2AX modulates Apoptosis and survival decisions
846. Very Delayed Infarction after Mild Focal Cerebral Ischemia: A Role for Apoptosis?
847. The role of the ubiquitin-proteasome pathway in Apoptosis
848. Regulation of Apoptosis by Alternative Pre-mRNA Splicing
849. Glucagon-Like Peptides: Regulators of Cell Proliferation, Differentiation, and Apoptosis
850. Calcium, free radicals and excitotoxins in neuronal Apoptosis
851. The regulatory role of nitric oxide in Apoptosis
852. Salinomycin induces Apoptosis and overcomes Apoptosis resistance in human cancer cells
853. Peroxynitrite Causes Apoptosis in Rat Thymocytes
854. Intracellular infection by Leishmania donovani inhibits macrophage Apoptosis.
855. HBXIP functions as a cofactor of survivin in Apoptosis suppression
856. Regulation of cell number in the mammalian gastrointestinal tract: the importance of Apoptosis
857. Apoptosis Biochemical events and relevance to cancer chemotherapy
858. Glucosylceramide synthase and Apoptosis
859. Apoptosis: a mechanism of acute and chronic liver injury
860. Apoptosis of vascular endothelial cells by fibroblast growth factor deprivation
861. Mechanisms of bacterial lipopolysaccharide-induced endothelial Apoptosis
862. Endothelial cells release phenotypically and quantitatively distinct microparticles in activation and Apoptosis
863. Transcription, Apoptosis and p53: catch-22
864. Neuronal Apoptosis in HIV infection in adults
865. Oxidative Stress Inhibits Apoptosis in Human Lymphoma Cells
866. Cellular signaling in thymocyte Apoptosis.
867. Shiga toxins and Apoptosis
868. Survivin: A Bifunctional Inhibitor of Apoptosis Protein
869. Neutrophil Apoptosis is delayed in patients with inflammatory bowel disease.
870. Internalization of Staphylococcus aureusby Endothelial Cells Induces Apoptosis
871. p53 Induces Apoptosis by Caspase Activation through Mitochondrial Cytochrome c Release
872. T-cell Apoptosis detected in situ during positive and negative selection in the thymus
873. Redox Regulation of the Caspases during Apoptosis
874. Apoptosis in procyclic Trypanosoma brucei rhodesiense in vitro.
875. Epithelial cell growth and differentiation. II. Intestinal Apoptosis
876. Autophagy inhibition enhances therapy-induced Apoptosis in a Myc-induced model of lymphoma
877. Antioxidant, Gallic Acid, Induces Apoptosis in HL-60RG Cells
878. Absence of excitotoxicity-induced Apoptosis in the hippocampus of mice lacking the Jnk3 gene
879. Interaction of c-Abl and p73α and their collaboration to induce Apoptosis
880. Apoptosis in normal and osteoarthritic human articular cartilage
881. Apoptosis and endometriosis.
882. p53RDL1 regulates p53-dependent Apoptosis
883. Granulocyte Apoptosis and inflammatory
884. Apoptosis, Stem Cells, and Tissue Regeneration
885. Identification of Deoxyribonuclease II as an Endonuclease Involved in Apoptosis
886. Control of Apoptosis by the BCL-2 protein family: implications for physiology and therapy
887. Survivin: Key Regulator of Mitosis and Apoptosis and Novel Target for Cancer Therapeutics
888. Endothelial Dysfunction, Inflammation, and Apoptosis in Diabetes Mellitus
889. Apoptosis in relevant clinical situations: contribution of Apoptosis in myocardial infarction
890. Bcl‐2 and Fas/APO‐1 regulate distinct pathways to lymphocyte Apoptosis.
891. DIET AND Apoptosis
892. Activation of programmed cell death (Apoptosis) by cisplatin, other anticancer drugs, toxins and hyperthermia
893. Sensitization for Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand-Induced Apoptosis by the Chemopreventive Agent Resveratrol
894. Activation and Cleavage of Caspase-3 in Apoptosis Induced by Experimental Cerebral Ischemia
895. CTLA4 mediates antigen-specific Apoptosis of human T cells
896. Statin-induced Apoptosis and skeletal myopathy
897. Specific Proteolytic Cleavage of Poly(ADP-ribose) Polymerase: An Early Marker of Chemotherapy-induced Apoptosis
898. Induction of Apoptosis by Apo-2 Ligand, a New Member of the Tumor Necrosis Factor Cytokine Family
899. Inhibition of Myofibroblast Apoptosis by Transforming Growth Factor β1
900. What is Apoptosis, and why is it important? Education and debate
901. BCL-2, BCL-XL Sequester BH3 Domain-Only Molecules Preventing BAX- and BAK-Mediated Mitochondrial Apoptosis
902. A mathematical model of caspase function in Apoptosis
903. Environmental toxicity, oxidative stress and Apoptosis: Ménage à Trois
904. Analysis of Apoptosis during hair follicle regression (catagen)
905. A critical role of neural-specific JNK3 for ischemic Apoptosis
906. Hippo promotes proliferation arrest and Apoptosis in the Salvador/Warts pathway
907. Evidence that BCL-2 represses Apoptosis by regulating endoplasmic reticulum-associated Ca2+ fluxes
908. The cytopathic effect of hiv is associated with Apoptosis
909. Measuring and Modeling Apoptosis in Single Cells
910. Regulation of Apoptosis: the ubiquitous way
911. Evidence of Apoptosis in human diabetic kidney
912. Noxa, a BH3-Only Member of the Bcl-2 Family and Candidate Mediator of p53-Induced Apoptosis
913. Endoplasmic reticulum stress contributes to beta cell Apoptosis in type 2 diabetes
914. The bcl-2 oncogene and Apoptosis.
915. Casper Is a FADD- and Caspase-Related Inducer of Apoptosis
916. Protein translocation in Apoptosis
917. Molecular controls of growth arrest and Apoptosis: p53-dependent and independent pathways.
918. Near-Infrared Fluorescent Imaging of Tumor Apoptosis
919. DNases and Apoptosis
920. p53: A Guide to Apoptosis
921. Overexpression of Akt/AKT can modulate chemotherapy-induced Apoptosis.
922. Apoptosis and Free Radicals
923. Tumor suppressor PTEN: modulator of cell signaling, growth, migration and Apoptosis
924. Induction of DNA strand breaks associated with Apoptosis during treatment of leukemias.
925. Mitochondrial permeability transition in Ca2+-dependent Apoptosis and necrosis
926. Expression and Targeting of the Apoptosis Inhibitor, Survivin, in Human Melanoma
927. CD20‐mediated Apoptosis: signalling through lipid rafts
928. Endoplasmic Reticulum Stress-induced Apoptosis
     MULTIPLE PATHWAYS AND ACTIVATION OF p53-UP-REGULATED MODULATOR OF Apoptosis (PUMA) AND NOXA BY p53
929. MECHANISMS OF Apoptosis THROUGH STRUCTURAL BIOLOGY
930. Enhanced Apoptosis in Metallothionein Null Cells
931. Apoptosis_A_general_comment20151105-21991-16lpwty.pdf?response-content-disposition=inline%3B%20filename%3DApoptosis_A_general_comment.pdf&X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Credential=AKIAIWOWYYGZ2Y53UL3A%2F20191105%2Fus-east-1%2Fs3%2Faws4_request&X-Amz-Date=20191105T024415Z&X-Amz-Expires=3600&X-Amz-SignedHeaders=host&X-Amz-Signature=9daa502479b808bf7ecee2df3c522c78b8302840b6fc5da839dcca7f5d189adf”>Apoptosis:ageneralcomment
932. FADD, a novel death domain-containing protein, interacts with the death domain of fas and initiates Apoptosis
933. Ceramide in Apoptosis—does it really matter?
934. PKB and the mitochondria: AKTing on Apoptosis
935. Evolving Concepts of Apoptosis in Idiopathic Pulmonary Fibrosis
936. Mesenchymal stem cells induce Apoptosis of activated T cells
937. FADD: Essential for Embryo Development and Signaling from Some, But Not All, Inducers of Apoptosis
938. Apoptosis and anti-Apoptosis signalling in glaucomatous retinopathy.
939. Chapter 2 Assays of Cell Viability: Discrimination of Cells Dying by Apoptosis
940. Oxidative stress: the mitochondria-dependent and mitochondria-independent pathways of Apoptosis
941. Serine/threonine protein phosphatases in Apoptosis
942. The roles of microRNA in cancer and Apoptosis
943. DFF, a Heterodimeric Protein That Functions Downstream of Caspase-3 to Trigger DNA Fragmentation during Apoptosis
944. CD36 gene transfer confers capacity for phagocytosis of cells undergoing Apoptosis.
945. p73 induces Apoptosis by different mechanisms
946. MATURE T LYMPHOCYTE Apoptosis—Immune Regulation in a Dynamic and Unpredictable Antigenic Environment
947. The role of hypoxia inducible factor 1 (HIF-1) in hypoxia induced Apoptosis
948. Activation of Apoptosis signalling pathways by reactive oxygen species
949. Apoptosis-inducing activity of vitamin C and vitamin K.
950. Apoptosis: Silencing the death receptors
951. Apoptosis in the developing CNS
952. Apoptosis in the absence of caspase 3
953. Survivin in Apoptosis control and cell cycle regulation in cancer.
954. Aging and regulation of Apoptosis.
955. MicroRNA-1 Regulates Cardiomyocyte Apoptosis by Targeting Bcl-2
956. Eosinophil Apoptosis and the resolution of airway inflammation in asthma.
957. Actin is cleaved during constitutive Apoptosis.
958. Adrenergic regulation of cardiac myocyte Apoptosis