BMI-1
January 24, 2020KETONE BODIES
January 24, 2020- … -activated protein kinase kinase kinase 3 (MEKK3) is required for lysophosphatidic acid (LPA)-mediated optimal i [kappa] B kinase [beta](IKK [beta])/nuclear factor …
- … -induced expression of iNOS and COX-2 in BV2 murine microglial cells: possible involvement of reactive oxygen species, p38 MAPK, and IKK/NF-κB signaling …
- … -insufficiency improves cardiac function in early-stages of myocardial infarction by protecting myocardium and increasing angiogenesis by promoting IKK …
- … ) stimulates matrix mentalloproteinase-9 (MMP-9) production in cultured human chorion trophoblast cells through TNF alpha receptor 1 signalling to IKK beta, ERK1/2 …
- … 8 acute infection of endothelial cells induces monocyte chemoattractant protein 1–dependent capillary-like structure formation: role of the IKK/NF-κB pathway
- … acid-induced iNOS gene expression in macrophages possibly through downregulation of toll-like receptor 2-mediated activation of Raf-MEK1/2-ERK1/2-IKK-NFκB
- … and chemosensitizes leukemic cells through inhibition of gene expression regulated by TNF-TNFR1-TRADD-TRAF2-NIK-TAK1-IKK pathway”[Biochem. Pharmacol …
- … and the beautiful: A small dibromotyrosine derivative from Pseudoceratina sp. sponge exhibits potent apoptotic effect through targeting IKK/NFκB signaling pathway
- … antagonist blocks histamine-induced proinflammatory cytokine production through inhibition of Ca2+-dependent protein kinase C, Raf/MEK/ERK and IKK/IκB/NF-κB …
- … as a target to increase apoptosis in primary mediastinal B-cell lymphoma (PMBL): Results of studies with rituximab (RTX), bortezomib (BTZ) and small molecule IKK …
- … attenuates TNF-α-induced iNOS expression in human endothelial cells: Involvement of Syk-mediated activation of PI3K-IKK-IκB signaling pathways
- … between apoptosis in primary mediastinal B-cell lymphoma (PMBL) and NF-\# 954; B Pathway Blockade: Bortezomib (BTZ), small molecule IKK inhibitor ML120B and …
- … cascade leading to apoptosis.) The anti-inflammatory phenolic curcumin from Curcuma species (turmeric)(Zingiberaceae) inhibits the IB kinase (IKK) and thus inhibits …
- … Conditioning and Ventilation held in Hanover for the first time: Air conditioning systems made in the Far East challenge traditional systems; IKK 2001-22. Internationale …
- … deacetylase inhibitors SAHA and NVP-LAQ824 is enhanced by interrupting NF-kappaB activation through a mechanism involving inhibition of IKK-mediated RelA/p65 …
- … disrupts tyrosine-phosphorylated phosphatidylinositol 3-kinase and myeloid differentiation factor-88 association, and inhibits MAPK/AP-1 and IKK/NF-κB-induced …
- … from the Chinese medicinal plant Caesalpinia sappan L., protects neurons from microglia-mediated inflammatory injuries via inhibition of IκB kinase (IKK)-NF-κB and …
- … growth factor-2 15-LOX, 15-lipoxygenase receptor tyrosine kinase LPS, lipopolysaccharide iGlu-R, inhibitory glutamate receptor LT, leukotriene IKK, inhibitor B kinase …
- … Impaired migration and proliferation of bone marrow-derived mesenchymal stem cells from patients with systemic lupus erythematosus were mediated by IKK-β
- … in this paper: ApoE, apolipoprotein E; BAE, bovine aortic endothelial; Coll, collagen; FG, fibrinogen; FN, fibronectin; IHC, immunohistochemistry; IKK, IκB kinase; LN …
- … Increases in Apoptosis in Primary Mediastinal B-Cell Lymphoma (PMBL) and NF-κB Pathway Blockade: Bortezomib (BTZ), Small Molecule IKK Inhibitor ML120B and …
- … inhibitor, suppresses growth and chemosensitizes leukemic cells through inhibition of gene expression regulated by TNF-TNFR1-TRADD-TRAF2-NIK-TAK1-IKK …
- … low-density lipoprotein-induced inflammation in human mesangial cells through upregulation of XBP1 and suppression of the IRE1α/IKK/NF‑κB pathway
- … mortality and district characteristics (IKK) of the TUeV Rheinland; Das Informationssystem ueber Krebsmortalitaet und Kreischarakteristika (IKK) des TUeV Rheinland
- … of Ethanolic Extract of Pericarps of Mangosteen (Garcinia mangostana Linn.) on WiDr Cells and Interaction Study of Alpha-mangosteen to IKK and VEGF Based on …
- … of LPS-induced NO and PGE2 production by asiatic acid via NF-κB inactivation in RAW 264.7 macrophages: possible involvement of the IKK and MAPK pathways
- … of the NF-κ B pathway by the leukemogenic TEL-Jak2 and TEL-Abl fusion proteins leads to the accumulation of antiapoptotic IAP proteins and involves IKK α
- … oxide level in tomato regulated by a mammalian IKK/NF-κB like signaling pathway? Is nitric oxide level in tomato regulated by a mammalian IKK/NFκB-like signaling …
- … Pathways Regulating Hepatic Apolipoprotein B100 Production: Roles of Mitogen-activated Protein Kinases (MAPKs) and Inhibitor of NFkappaB Kinase (IKK) …
- … pylori Induction in Gastric Mucosal Prostaglandin and Nitric Oxide Generation Is Dependent on MAPK/ERK-Mediated Activation of IKK-β and cPLA2 …
- … the DKV planner’s forum at the IKK 2000; Integration lufttechnischer Systemloesungen in die Gebaeudeautomation. Beitrag vom DKV-Planerforum waehrend der IKK …
- … the solution structure of IκB kinase (IKK) subunit γ and its interaction with kaposi sarcoma-associated herpes virus flice-interacting protein and IKK subunit β by EPR …
- 129. OVARIAN PHENOTYPE OF THE IKK CONDITIONAL KNOCKOUT MOUSE
- 147: Inhibitory kappa B kinase (IKK) inhibition attenuates infarct size in a murine model of myocardial ischemia-reperfusion
- 15‐Deoxy‐Δ12,14‐prostaglandin J2 inhibits IL‐1β‐induced IKK enzymatic activity and IκBα degradation in rat chondrocytes through a PPARγ‐independent pathway
- 20-HETE Activates Endothelial ACE via an IKK/NF-kB Dependent Pathway
- 20-SOLA, a Novel Water Soluble 20-HETE Antagonist, Reduces Blood Pressure Through Regulation of Vascular ACE Expression via an IKK Dependent Pathway
- 241 Tnf-α Induction of Infant Murine Brain Inflammation Via IKK/Nf Kappa B Signalling: A Potential Model for Paediatric Neuroinflammation
- 3, 5-Disubstituted-indole-7-carboxamides: The discovery of a novel series of potent, selective inhibitors of IKK-β
- 3D‐QSAR Studies on a Class of IKK‐2 Inhibitors with GALAHAD Used to Develop Molecular Alignment Models
- 3D‐QSAR Study of Pyridine Derivates as IKK‐2 Inhibitors
- 4-Hydroxyestradiol induces neoplastic transformation of human breast epithelial cells by activating IKK-NF-κB signaling: possible involvement of reactive oxygen …
- 5-(1H-Benzimidazol-1-yl)-3-alkoxy-2-thiophenecarbonitriles as potent, selective, inhibitors of IKK-ε kinase
- 57: Pivotal role of the IKK-related kinase IKK epsilon to modulate IL29 or type I IFN induction during hepatitis C virus infection
- A dominant function of IKK/NF-κB signaling in global lipopolysaccharide-induced gene expression
- A feedforward loop of NLRC5 (de) ubiquitination keeps IKK–NF-κB in check
- A key mediator, PTX3, of IKK/IκB/NF-κB exacerbates human umbilical vein endothelial cell injury and dysfunction
- A Kinase Upstream of IKK
- A negative feedback loop between miR‐200b and the nuclear factor‐κB pathway via IKBKB/IKK‐β in breast cancer cells
- A new role for IKK-α in hepatitis C virus-induced lipogenesis.
- A Novel IKK Inhibitor IMD-0560: Suppresses Chronic Remodeling after Myocardial Ischemia
- A Novel IKK Inhibitor Prevents Progression of Neointimal Formation After Arterial Injury in Mice
- A novel IKK inhibitor prevents progression of restenosis after arterial injury in mice
- A novel IKK inhibitor suppresses heart failure and chronic remodeling after myocardial ischemia via MMP alteration
- A novel role for IκB kinase (IKK) α and IKKβ in ERK-dependent up-regulation of MUC5AC mucin transcription by Streptococcus pneumoniae
- A novel X-linked disorder of immune deficiency and hypohidrotic ectodermal dysplasia is allelic to incontinentia pigmenti and due to mutations in IKK-gamma …
- A novel, highly selective, tight binding IκB kinase-2 (IKK-2) inhibitor: a tool to correlate IKK-2 activity to the fate and functions of the components of the nuclear factor-κB …
- A positive feedback loop involving EGFR/Akt/mTORC1 and IKK/NF-κB regulates head and neck squamous cell carcinoma proliferation
- A recurrent deletion in the ubiquitously expressed NEMO (IKK-γ) gene accounts for the vast majority of incontinentia pigmenti mutations
- A selective IKK-2 inhibitor blocks NF-κB-dependent gene expression in interleukin-1β-stimulated synovial fibroblasts
- A selective novel low‐molecular‐weight inhibitor of IκB kinase‐β (IKK‐β) prevents pulmonary inflammation and shows broad anti‐inflammatory activity
- A Specific IKK Inhibitor Suppresses Experimental Autoimmune Myocarditis in Rats
- A TNF &alphaA-responsive kinase activity may play a key role in IKK activation.
- A Truncated Form of IKKa Is Responsible for Specific Nuclear IKK Activity in Colorectal Cancer
- A truncated form of IKKα is responsible for specific nuclear IKK activity in colorectal cancer
- A truncated form of IKKα is responsible for specific nuclear IKK activity in colorectal cancer
- A ubiquitin replacement strategy in human cells reveals distinct mechanisms of IKK activation by TNFα and IL-1β
- A20-binding inhibitor of nuclear factor-B (NF-B)-2 (ABIN-2) is an activator of inhibitor of NF-B (IB) kinase (IKK)-mediated NF-B transcriptional activity
- AB0601 Anti-arthritis effects of (E)-2, 4-bis (P-hydroxyphenyl)-2-butenal through inhibition of IKK-beta activity
- Abnormal morphogenesis but intact IKK activation in mice lacking the IKKα subunit of IκB kinase
- Abstract A41: The ASK1/IKK signaling axis mediates crosstalk between inflammation and apoptosis
- Abstract B59: IKK-mediated phosphorylation of the androgen receptor: A mechanism to modulate AR-cofactor interaction
- Abstract B71: Chemosensitization to bleomycin conferred by a constitutive activation of IKK pathway in viral FLIP expressing cells
- Abstract LB-144: I-kappa-B kinase (IKK) ε expression in pancreatic ductal adenocarcinoma
- Abstract LB-206: A novel scaffold that targets the IKK complex
- Abstract P1-01-11: Nuclear immunohistochemical IKK-εexpression in flat epithelial atypia (FEA) of the breast: A predictor of ipsilateral ADH, in-situ or invasive …
- Abstract P5-05-10: EIA-Induced PP2A Expression Prevents β-Trcp Mediated FOXO3a Degradation and Enhances Chemosensitization by Inhibiting TAK1/IKK …
- Abstract# 1196: Pro-inflammatory cytokine RANKL promotes tumor metastasis through the RANK-IKK\# 945; pathway
- Abstract# 1486: E1A-induced PP2A expression prevents\# 946; TrCP-mediated FOXO3a degradation and enhances chemosensitization by inhibiting TAK1/IKK …
- Abstract# 1790: Different roles of IKK alpha and IKK beta on NF-kB pathway in mantle cell lymphoma and diffuse large B-cell ympoma
- Abstract# 441: TRAF2 phosphorylation at Ser-55 inhibits stress-induced cell death by promoting prolonged IKK activation
- Abstract# 4700: p65 activity and ZAP-70 status predict the sensitivity of chronic lymphocytic leukemia cells to the selective IKK inhibitor BMS-345541
- Abstract# 4958: Pro-inflammatory cytokine RANKL promotes tumor metastasis through the RANK-IKK\# 945; pathway
- Abstract# 5050: 4-Hydroxyestradiol induces anchorage-independent growth of human mammary epithelial cells through ROS-mediated activation of IKK
- Abstract# 5269: TRAF2 suppresses IKK activity and inhibits TNFa-induced cell death independent of NF-kB activation
- Abstract# 5271: PKC-iota associates and phosphorylates IKK-\# 945;/\# 946; in breast cancer cell
- Abstract# 5488: IKK inhibitor Bay 11-7082 induces necrotic cell death in pre-B ALL cells
- Abstract# 5672: The role of IKK\# 946;/TSC1 regulation in tumorigenesis and insulin resistance
- Accumulation of phosphorylated IκBα and activated IKK in nodes of Ranvier
- Acetylation of MEK2 and IκB kinase (IKK) activation loop residues by YopJ inhibits signaling
- Activation mechanisms of endothelial NF-κB, IKK, and MAP kinase by tert-butyl hydroperoxide
- Activation of a Subset of Genes by IFN-γ Requires IKKβ but Not Interferon-Dependent Activation of NF-κB
- Activation of G-protein-coupled estrogen receptor inhibits the migration of human nonsmall cell lung cancer cells via IKK-β/NF-κB signals
- Activation of IKK by thymosin α1 requires the TRAF6 signalling pathway
- Activation of IKK by TNFα requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO
- Activation of IKK/NF-κB provokes renal inflammatory responses in guanylyl cyclase/natriuretic peptide receptor-A gene-knockout mice
- Activation of nuclear factor κB through the IKK complex by the topoisomerase poisons SN38 and doxorubicin: a brake to apoptosis in HeLa human carcinoma cells
- Activation of PI3K/Akt/IKK-α/NF-κB signaling pathway is required for the apoptosis-evasion in human salivary adenoid cystic carcinoma: its inhibition by quercetin
- Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains
- Activation of the IκBα kinase (IKK) complex by double-stranded RNA-binding defective and catalytic inactive mutants of the interferon-inducible protein kinase …
- Activation of the virus-induced IKK/NF-kB signaling axis is critical for the replication of HCMV in quiescent cells
- Activation of the virus‐induced IKK/NF‐κB signalling axis is critical for the replication of human cytomegalovirus in quiescent cells
- Active nuclear IKK correlates with metastatic risk in cutaneous squamous cell carcinoma
- Activity of bortezomib, a proteasome inhibitor, in breast cancer cells: Association with negative estrogen receptor and IKK/NF-κB expression
- Adenovirus mediated gene transfer of mutated IKK and IκBα reveal NF-κB dependent as well as independent pathway of HAS1 activation
- Adenovirus-mediated IKK β KA expression sensitizes prostate carcinoma cells to TRAIL-induced apoptosis
- Adiponectin blocks interleukin-18-mediated endothelial cell death via APPL1-dependent AMP-activated protein kinase (AMPK) activation and IKK/NF-κB/PTEN …
- Advances in targeting IKK and IKK-related kinases for cancer therapy
- Akt-dependent regulation of NF-κB is controlled by mTOR and Raptor in association with IKK
- Akt/IKK [alpha]/Vav1 Signaling in Endothelial Cell Survival and Angiogenesis
- Alpha-lipoic acid inhibits TNF-α induced NF-κB activation through blocking of MEKK1–MKK4–IKK signaling cascades
- Altered TAB1: IKK Interaction Promotes TGF-β-Mediated NF-κB Activation During Breast Cancer Progression
- Amelioration of Arthritis by Intraarticular Dominant Negative IKKβ Gene Therapy Using Adeno-Associated Virus Type 5
- Aminopyridinecarboxamide-based inhaled IKK-2 inhibitors for asthma and COPD: Structure–activity relationship
- An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice
- Angiogenin mediates immune modulation and antiinflammatory reaction attenuating protein kinase IKK-ε in human corneal fibroblast cells
- Annexin-1 interacts with NEMO and RIP1 to constitutively activate IKK complex and NF-κB: implication in breast cancer metastasis
- Anthrax lethal toxin enhances I kappa B kinase (IKK) activation and differentially regulates pro-inflammatory genes in human endothelium (135.3)
- Anti-inflammatory effects of IKK inhibitor XII, thymulin, and fat-soluble antioxidants in LPS-treated mice
- Anticancer agent CHS 828 suppresses nuclear factor‐κB activity in cancer cells through downregulation of IKK activity
- Apigenin potentiates the growth inhibitory effects by IKK-β-mediated NF-κB activation in pancreatic cancer cells
- Apigenin suppresses IKK activation and downstream signaling leading to prostate cancer inhibition.
- Apoptotic role of IKK in T-ALL therapeutic response
- Are the IKKs and IKK-related kinases TBK1 and IKK-ɛ similarly activated?
- Aspirin inhibits IKK-β-mediated prostate cancer cell invasion by targeting matrix metalloproteinase-9 and urokinase-type plasminogen activator
- Association of a Network of Interferon-Stimulated Genes with a Locus Encoding a Negative Regulator of Non-conventional IKK Kinases and IFNB1
- Association of the adaptor TANK with the IκB kinase (IKK) regulator NEMO connects IKK complexes with IKKε and TBK1 kinases
- Astragaloside IV facilitates glucose transport in C2C12 myotubes through the IRS1/AKT pathway and suppresses the palmitate-induced activation of the IKK …
- ATM is required for IκB kinase (IKK) activation in response to DNA double strand breaks
- ATM-and NEMO-dependent ELKS ubiquitination coordinates TAK1-mediated IKK activation in response to genotoxic stress
- ATM-dependent nuclear accumulation of IKK-α plays an important role in the regulation of p73-mediated apoptosis in response to cisplatin
- ATP alters IKK-2 inhibitor affinity for IKK2 enzyme and reveals non-equivalent inhibitor binding sites
- ATS Abstract: IKK-ß Is Required For Rhinovirus Induced IFN-ß, IFN-» And Pro-inflammatory Cytokine Production In Vitro And In Vivo
- Atypical forms of incontinentia pigmenti in male individuals result from mutations of a cytosine tract in exon 10 of NEMO (IKK-γ)
- Aurora and IKK kinases cooperatively interact to protect multiple myeloma cells from Apo2L/TRAIL
- Autophagy protects intestinal epithelial cells against deoxynivalenol toxicity by alleviating oxidative stress via IKK signaling pathway
- BAG3 is required for IKK α nuclear translocation and emergence of castration resistant prostate cancer
- Bcl3 phosphorylation by Akt, Erk2, and IKK is required for its transcriptional activity
- Benznidazole blocks NF-κB activation but not AP-1 through inhibition of IKK
- Benzoxathiolone LYR-64 inhibits NF-kB activation via IKK complexin LPS-stimuated macrophages RAW 264. 7
- Berberine suppresses in vitro migration and invasion of human SCC-4 tongue squamous cancer cells through the inhibitions of FAK, IKK, NF-κB, u-PA and MMP-2 and …
- Betafectin immunomodulator increases the activities of JNK and IKK kinases and increases the nuclear translocation of AP-1 in macrophage cells.
- BIOCHEMICAL CHARACTERIZATION OF SUPPRESSOR OF IKK-ε AND NAK-ASSOCIATED PROTEIN 1
- Biochemical Properties of IKK and Bcl3
- Bioinformatics Predictions of IKK Related Proteins Binding Long Non-Coding RNAs
- Biologic sequelae of IκB kinase (IKK) inhibition in multiple myeloma: therapeutic implications
- Biomechanical signals inhibit IKK activity to attenuate NF‐κB transcription activity in inflamed chondrocytes
- Bortezomib Increases IL-8 Expression in Ovarian Cancer Cells Through IKK and EGR-1 Pathways
- Brazilin selectively disrupts proximal IL-1 receptor signaling complex formation by targeting an IKK-upstream signaling components
- Breaking resistance of pancreatic cancer cells to an attenuated vesicular stomatitis virus through a novel activity of IKK inhibitor TPCA-1
- C-Terminal Serine Rich Region of IKK– Interacts with Bfl-1, a Homologue of Bcl-2
- C70 THE NEXT NEW THERAPEUTIC TARGET? TRANSLATIONAL STUDIES OF COPD THERAPIES: The Effect Of An Ikgr; b-Kinase-[Beta](IKK [Beta]) Inhibitor On …
- Ca2+/calmodulin-dependent protein phosphatase calcineurin mediates the expression of iNOS through IKK and NF-κB activity in LPS-stimulated mouse peritoneal …
- Caffeic acid regulates LPS-induced NF-κB activation through NIK/IKK and c-Src/ERK signaling pathways in endothelial cells
- Cardiomyocyte-specific IκB kinase (IKK)/NF-κB activation induces reversible inflammatory cardiomyopathy and heart failure
- Carnosic acid modulates Akt/IKK/NF-κB signaling by PP2A and induces intrinsic and extrinsic pathway mediated apoptosis in human prostate carcinoma PC-3 cells
- CD147 promotes IKK/IκB/NF-κB pathway to resist TNF-induced apoptosis in rheumatoid arthritis synovial fibroblasts
- CFC replacement in the focus of attention at the IKK’91 in Essen. IKK 91 in Essen im Zeichen der FCKW-Substitution
- Characterization of the bovine IκB kinases (IKK) α and IKKβ, the regulatory subunit NEMO and their substrate IκBα
- Characterization of the IKK Signaling Complex
- Characterization of the inhibitor of kappaB kinase (IKK) complex in granulosa cell tumors of the ovary and granulosa cell tumor-derived cell lines
- Chemosensitization in non‐small cell lung cancer cells by IKK inhibitor occurs via NF‐κB and mitochondrial cytochrome c cascade
- Chlamydia pneumoniae activates IKK/IκB-mediated signaling, which is inhibited by 4-HNE and following primary exposure
- Chronic alcohol exposure exacerbates inflammation and triggers pancreatic acinar-to-ductal metaplasia through PI3K/Akt/IKK
- cIAP2 negatively regulates proliferation and tumourigenesis by repressing IKK activity and maintaining p53 function
- Ciglitazone ameliorates lung inflammation by modulating the IKK/NF-κB pathway following hemorrhagic shock
- CIGLITAZONE REDUCES NF-κB ACTIVITY BY INHIBITING IKK IN HEMORRHAGIC SHOCK.: 58
- Cis-guggulsterone inhibits the IKK/NF-κB pathway, whereas trans-guggulsterone inhibits MAPK/AP-1 in MCF‑7 breast cancer cells: Guggulsterone regulates …
- CITED2 modulates metastatic ability through effects on IKK-alpha in breast cancer cells
- Classical NF-κB activation impairs skeletal muscle oxidative phenotype by reducing IKK-α expression
- Clinical study on the relationship between the activation of the IKK-IκB-NFκB pathway and insulin resistance
- Cloning and characterization of an IKK homologue from pearl oyster, Pinctada fucata
- Clostridium difficile toxin A promotes dendritic cell maturation and chemokine CXCL2 expression through p38, IKK, and the NF-κB signaling pathway
- Coexpression of proangiogenic factors IL-8 and VEGF by human head and neck squamous cell carcinoma involves coactivation by MEK-MAPK and IKK-NF-κB signal …
- Coincident enrichment of phosphorylated IκBα, activated IKK, and phosphorylated p65 in the axon initial segment of neurons
- Collagen and prostaglandin E2 regulate aromatase expression through the PI3K/AKT/IKK and the MAP kinase pathways in adipose stromal cells
- Combined use of pharmacokinetic modeling and a steady-state delivery approach allows early assessment of IκB kinase-2 (IKK-2) target safety and efficacy
- Complete Reconstitution of Human IκB Kinase (IKK) Complex in Yeast ASSESSMENT OF ITS STOICHIOMETRY AND THE ROLE OF IKKγ ON THE COMPLEX …
- Compound FLZ inhibits lipopolysaccharide-induced inflammatory effects via down-regulation of the TAK-IKK and TAK-JNK/p38MAPK pathways in RAW264. 7 …
- Comprehending the complex connection between PKCβ, TAK1, and IKK in BCR signaling
- Compressive mechanical stress may activate IKK-NF-κB through proinflammatory cytokines in MC3T3-E1 cells
- Conjugated linoleic acids produced by Lactobacillus dissociates IKK-γ and Hsp90 complex in Helicobacter pylori-infected gastric epithelial cells
- Connecting inflammation and cancer through the IKK-NF-κB nexus
- Constitutive Activation of NF-kappaB in Prostate Carcinoma Cells Through a Positive Feedback Loop: Implication of Inducible IKK-Related Kinase (IKKi)
- Constitutive Activation of NF-Kb in Prostate Carcinoma Cells through a Positive Feedback Loop: Implication of Inducible IKK-Related Kinase (IKKi)
- Constitutive activation of TAK1 by HTLV-1 tax-dependent overexpression of TAB2 induces activation of JNK-ATF2 but not IKK-NF-κB
- Constitutive and interleukin-1-inducible phosphorylation of p65 NF-κB at serine 536 is mediated by multiple protein kinases including IκB kinase (IKK)-α, IKKβ, IKKϵ …
- Context-dependent regulation of autophagy by IKK-NF-κB signaling: Impact on the aging process
- Control of canonical NF-κB activation through the NIK–IKK complex pathway
- Control of osteoclast activity and bone loss by IKK subunits: new targets for therapy
- Coordination of the canonical and noncanonical IKK/NF-κB signaling pathways in HTLV-I tax-mediated tumorigenesis
- Correlation between the signal pathway IKK/NF-? B and the anti-oxidant activity in asthma rats and the modulation of Ginkgo biloba extract
- Counter-regulation in the IKK family
- Crosstalk between the NF‐κB activating IKK‐complex and the CSN signalosome
- Crystal structure of a vFlip-IKKγ complex: insights into viral activation of the IKK signalosome
- Curcumin dually inhibits both mTOR and NF-κB pathways through a crossed PI3K/Akt/IKK signaling axis in adenoid cystic carcinoma
- Curcumin Treatment Suppresses IKK Kinase Activity of Salivary Cells of Patients with Head and Neck Cancer: A Pilot Study
- Cutting edge: the IκB kinase (IKK) inhibitor, NEMO-binding domain peptide, blocks inflammatory injury in murine colitis
- Cytokine receptor signaling activates an IKK-dependent phosphorylation of PUMA to prevent cell death
- Cytosolic Hsp60 is involved in the NF-κB-dependent survival of cancer cells via IKK regulation
- Cytotoxic Necrotizing Factor 1 Prevents Apoptosis via the AKT/IKK pathway: Role of NF-κB and Bcl-2
- Daphnetin inhibits TNF‐α and VEGF‐induced angiogenesis through inhibition of the IKK s/IκBα/NF‐κB, Src/FAK/ERK 1/2 and Akt signalling pathways
- Davallia bilabiata Inhibits TNF-α-Induced Adhesion Molecules and Chemokines by Suppressing IKK/NF-kappa B Pathway in Vascular Endothelial Cells
- Dbl and the Rho GTPases activate NFκB by IκB kinase (IKK)-dependent and IKK-independent pathways
- De-ubiquitylation is the most critical step in the ubiquitin-mediated homeostatic control of the NF-jB/IKK basal activity
- De-ubiquitylation is the most critical step in the ubiquitin-mediated homeostatic control of the NF-κB/IKK basal activity
- Deactivation of the kinase IKK by CUEDC2 through recruitment of the phosphatase PP1
- Decreased IKK Signaling in Skeletal Muscle of Patients with Hyperglycemic Crisis.
- Deficient natural killer cell cytotoxicity in patients with IKK-γ/NEMO mutations
- Design and preparation of 2-benzamido-pyrimidines as inhibitors of IKK
- determine distinct IKK α Pleiotropic functions of TNF
- Dextran-g-lauric acid as IKK complex inhibitor carrier
- Differential IKK/NF-kB Activity Is Mediated by TSC2 through mTORC1 in PTEN-Null Prostate Cancer and Tuberous Sclerosis Complex Tumor Cells
- Differential IKK/NF-κB activity is mediated by TSC2 through mTORC1 in PTEN-null prostate cancer and tuberous sclerosis complex tumor cells
- Differential Requirement for the IKK
- Direct Phosphorylation of I kappa B by IKK [small alpha, Greek] and IKK [small beta, Greek]: Discrimination Between Free and NF-kappa B-Bound Substrate
- Direct, noncatalytic mechanism of IKK inhibition by A20
- Discovery of 6-Aryl-7-alkoxyisoquinoline Inhibitors of IκB Kinase-β (IKK-β)
- Discovery of 6-aryl-azabenzimidaoles that inhibit the TBK1/IKK-ε kinases
- Discovery of a novel IKK-β inhibitor by ligand-based virtual screening techniques
- Discovery of novel and selective IKK-β serine-threonine protein kinase inhibitors. Part 1
- DISCOVERY OF NOVEL IKK-Β INHIBITOR BY STRUCTURAL MODIFICATIONS OF CHLORPROPAMIDE AND NATEGLINIDE
- Discovery of novel potent nuclear factor kappa‐B inhibitors (IKK‐β) via extensive ligand‐based modeling and virtual screening
- Discovery of piperidinyl aminopyrimidine derivatives as IKK-2 inhibitors
- Disrupting the inhibitory Kappa B kinase (IKK)-Aurora A axis in cancer
- Disruption of IκB kinase (IKK)-mediated RelA serine 536 phosphorylation sensitizes human multiple myeloma cells to histone deacetylase (HDAC) inhibitors
- Distinct activation mechanisms of NF-κB regulator inhibitor of NF-κB kinase (IKK) by isoforms of the cell death regulator cellular FLICE-like inhibitory protein (cFLIP)
- Distinct B subunits of PP 2A regulate the NF‐κB signalling pathway through dephosphorylation of IKK β, IκBα and RelA
- Distinct roles for JNK and IKK activation in agouti-related peptide neurons in the development of obesity and insulin resistance
- Diversity oriented synthesis and IKK inhibition of aminobenzimidazole tethered quinazoline-2, 4-diones, thioxoquinazolin-4-ones, benzodiazepine-2, 3, 5-triones …
- DMA, a Bisbenzimidazole, Offers Radioprotection by Promoting NFκB Transactivation through NIK/IKK in Human Glioma Cells
- Docosahexaenoic acid inhibition of inflammation is partially via cross-talk between Nrf2/heme oxygenase 1 and IKK/NF-κB pathways
- Domain-specific interaction with the IκB kinase (IKK) regulatory subunit IKKγ is an essential step in Tax-mediated activation of IKK
- Drosophila IKK-related kinase Ik2 and Katanin p60-like 1 regulate dendrite pruning of sensory neuron during metamorphosis
- Drosophila IKK-related kinase regulates nonapoptotic function of caspases via degradation of IAPs
- Dynamic Characterization of the IKK: κBα: NFκB Negative Feedback Loop Using Real-Time Bioluminescence Imaging
- Dynamic interaction of stress granules, DDX3X, and IKK-α mediates multiple functions in hepatitis C virus infection
- E1A inhibition of radiation-induced NF-κB activity through suppression of IKK activity and IκB degradation, independent of Akt activation
- Effect and mechanism of IKK-2 receptor blocker on corneal stromal fibroblasts
- Effect and significance of anisodamine on I-kappaB kinase (IKK) in traumatic lung injury
- Effect of Collaterals-smoothing Drugs on Expressions of IκB-a and IKK-a in Sciatic Nerve of Diabetic Rats
- Effect of FK506 and Cyclosporin A on IκBα Degradation and IKK Pathway in Bronchial Epithelial Cells, Monocytes, Lymphocytes and Alveolar Macrophages
- Effect of IKK-2 Inhibitor on Local Th1 and Th2 Type Inflammation
- Effect of IKK-beta specific inhibitor PS1145 on NF-kappaB activity and apoptosis in prostate carcinoma cell lines
- Effect of Kuijieling decoction on proteins expression of IKK-alpha in colonic mucosa of ulcerative colitis model rats
- Effect of Rosiglitazone on Insulin Resistance and ROS. IKK Signaling Pathway in Vascular Endothelial Cells
- Effect of rosiglitazone on phosphorylation IKK and IκBα in the Heart of STZ Diabetic Rats [J]
- Effective suppression of pro‐inflammatory molecules by DHCA via IKK‐NF‐κB pathway, in vitro and in vivo
- Effects of a brief high-fat diet and acute exercise on the mTORC1 and IKK/NF-κB pathways in rat skeletal muscle
- Effects of IKK inhibitor PS1145 on NF-κ B function, proliferation, apoptosis and invasion activity in prostate carcinoma cells
- Effects of P-MAPA immunomodulator on Toll-like receptor 2, ROS, nitric oxide, MAPKp38 and IKK in PBMC and macrophages from dogs with visceral leishmaniasis
- Effects of Soothing Liver and Invigorating Spleen Recipes on the IKK-NF-B Signaling Pathway in Kupffer Cells of Nonalcoholic Steatohepatitis Rats
- Effects of TCDD upon IκB and IKK subunits localized in microsomes by proteomics
- El BUSINESS If IKK
- Embryonic lethality, liver degeneration, and impaired NF-κB activation in IKK-β-deficient mice
- EMMPRIN activates multiple transcription factors in cardiomyocytes, and induces interleukin-18 expression via Rac1-dependent PI3K/Akt/IKK/NF-κB andMKK7/JNK …
- Endothelial cell injury and dysfunction induced by silver nanoparticles through oxidative stress via IKK/NF-κB pathways
- Endothelial IKK β Signaling is Required for Monocyte Adhesion under Laminar Flow Conditions
- Endothelial-specific Deletion of Inhibitor of Kappa-B Kinase-β (IKK-β)
- Energy calibration of the IKK fast chopper with 238U standards
- Epithelial-cell-intrinsic IKK-β expression regulates intestinal immune homeostasis
- Epstein-Barr virus-encoded EBNA1 inhibits the canonical NF-κB pathway in carcinoma cells by inhibiting IKK phosphorylation
- Epstein–Barr virus-encoded latent infection membrane protein 1 regulates the processing of p100 NF-κ B2 to p52 via an IKK γ/NEMO-independent signalling …
- ER stress activates NF-κB by integrating functions of basal IKK activity, IRE1 and PERK
- ERK is an anti-inflammatory signal that suppresses expression of NF-κB-dependent inflammatory genes by inhibiting IKK activity in endothelial cells
- Erratum to” Discovery of novel and selective IKK-b serine-threonine protein kinase inhibitors. Part 1″-(Bioorg. Med. Chem. Lett. 13 (2003) 913)
- Etanercept Reverses Downregulation of Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Alpha (IKK [alpha]) in Psoriasis
- Evidence that TNF-TNFR1-TRADD-TRAF2-RIP-TAK1-IKK pathway mediates constitutive NF-κ B activation and proliferation in human head and neck …
- Exclusion from the Golgi and very low levels of HTLV-2 Tax ubiquitination do not prevent IKK-gamma/NEMO relocalization and NF-B activation
- Exclusion from the Golgi and very low levels of HTLV-2 Tax ubiquitination do not prevent IKK-gamma/NEMO relocalization and NF-κB activation
- Exploring Suppressor of IKK Epsilon’s Interaction with Cytoskeletal Proteins
- Expression and function of NIK‐and IKK 2‐binding protein (NIBP) in mouse enteric nervous system
- Expression and regulation of inducible IκB kinase (IKK-i) in human fibroblast-like synoviocytes
- Expression, purification and functional characterization of IκB kinase-2 (IKK-2) mutants
- Faculty, IKK
- FAF1 suppresses IκB kinase (IKK) activation by disrupting the IKK complex assembly
- Falcarindiol impairs the expression of inducible nitric oxide synthase by abrogating the activation of IKK and JAK in rat primary astrocytes
- Fanconi anemia protein complex is a novel target of the IKK signalsome
- Feed-forward signaling of TNF-α and NF-κB via IKK-β pathway contributes to insulin resistance and coronary arteriolar dysfunction in type 2 diabetic mice
- Fentanyl Suppresses the Survival of CD4+ T Cells Isolated from Human Umbilical Cord Blood through Inhibition of IKKs‐mediated NF‐κB Activation
- fibrosis) at 28-days post reperfusion, which was markedly reduced by the late administration of IKK16. Conclusion: The late inhibition of IKK may, therefore, have …
- Flavokawain B, the hepatotoxic constituent from kava root, induces GSH-sensitive oxidative stress through modulation of IKK/NF-κB and MAPK signaling pathways
- Fluticasone reduces IL-6 and IL-8 production of cystic fibrosis bronchial epithelial cells via IKK-β kinase pathway
- FOXO 3 as a new IKK‐ε‐controlled check‐point of regulation of IFN‐β expression
- FoxO transcription factor is delocalized in CML patients by Bcr-Abl induced PI3K/AKT activation and IKK pathway and can be reactivated by Imatinib treatment
- FoxO Transcription Factor Is Delocalized in CML Patients by Bcr-Abl Induced PI3K/AKT Activation and IKK Pathway and Can Be Reactivated by Imatinib Treatment.
- Functional analysis of astroglial IKK/NF-KappaB signaling in brain development and homeostasis
- Functional Role of c-Src in IL-1–Induced NF-κB Activation: c-Src Is a Component of the IKK Complex
- GD2+ breast cancer stem cell growth is dependent on NFκB signaling and suppressed by the IKK inhibitor BMS345541 in vitro and in vivo
- Genistein sensitizes bladder cancer cells to HCPT treatment in vitro and in vivo via ATM/NF-κB/IKK pathway-induced apoptosis
- Ghrelin Suppression of Helicobacter pylori-Induced Gastric Mucosal Expression of iNOS is Mediated through the Inhibition of IKK-β Activation by cNOS …
- Gold compound auranofin inhibits IκB kinase (IKK) by modifying Cys-179 of IKKβ subunit
- GPx-1 Gene Delivery Modulates NFκB Activation Following Diverse Environmental Injuries Through a Specific Subunit of the IKK Complex
- GW26-e1432 Effect of Rosiglitazone on Insulin Resistance and ROS/IKK Signaling Pathway in Vascular Endothelial Cells
- GW26-e2212 Effect of Atorvastatin on IKK/NF-кB Pathway of Insulin Resistance in Vascular Endothelial Cells
- GW27-e0848 Effect of Celastrol on Insulin Resistance and ROS/IKK Signaling Pathway in Vascular Endothelial Cells
- H-RN, a novel antiangiogenic peptide derived from hepatocyte growth factor inhibits inflammation in vitro and in vivo through PI3K/AKT/IKK/NF-κB signal pathway
- hCINAP negatively regulates NF-κB signaling by recruiting the phosphatase PP1 to deactivate IKK complex
- HDAC/IKK inhibition therapies in solid tumors.
- Heat shock treatment suppresses angiotensin II-induced activation of NF-κB pathway and heart inflammation: a role for IKK depletion by heat shock?
- Hematopoietic progenitor kinase-1 (HPK1) stress response signaling pathway activates IκB kinases (IKK-α/β) and IKK-β is a developmentally regulated …
- Hepatic activation of IKK/NFκB signaling induces liver fibrosis via macrophage‐mediated chronic inflammation
- Hepatitis C virus infection activates an innate pathway involving IKK-α in lipogenesis and viral assembly
- Hepatocyte-specific IKK-β activation enhances VLDL-triglyceride production in APOE* 3-Leiden mice
- Hepatoprotective effect of quercetin against LPS/d-GalN induced acute liver injury in mice by inhibiting the IKK/NF-κB and MAPK signal pathways
- High glucose-induced IKK-Hsp-90 interaction contributes to endothelial dysfunction
- Hijacking of host cell IKK signalosomes by the transforming parasite Theileria
- Histone deacetylase (HDAC) inhibition induces IκB kinase (IKK)-dependent interleukin-8/CXCL8 expression in ovarian cancer cells
- Histone H3 phosphorylation by IKK-α is critical for cytokine-induced gene expression
- Hit Identification of IKK-beta Natural Product Inhibitor
- Hit-to-lead studies: the discovery of potent, orally active, thiophenecarboxamide IKK-2 inhibitors
- Honokiol ameliorates endothelial dysfunction through suppression of PTX3 expression, a key mediator of IKK/IκB/NF-κB, in atherosclerotic cell model
- Honokiol inhibits TNF-α-stimulated NF-κB activation and NF-κB-regulated gene expression through suppression of IKK activation
- Host and parasite-derived IKK activities direct distinct temporal phases of NF-κB activation and target gene expression following Toxoplasma gondii infection
- How NF-κB is activated: the role of the IκB kinase (IKK) complex
- HSP27 regulates IL-1 stimulated IKK activation through interacting with TRAF6 and affecting its ubiquitination
- Hsp90 inhibition results in autophagy-mediated proteasome-independent degradation of IκB kinase (IKK)
- HTLV-1 tax functions as a ubiquitin E3 ligase for direct IKK activation via synthesis of mixed-linkage polyubiquitin chains
- HTLV-1 tax induces formation of the active macromolecular IKK complex by generating Lys63-and Met1-linked hybrid polyubiquitin chains
- HTLV-1 Tax protein induces autophagy via IKK in human astroglioma cells: a protective mechanism against death receptor-mediated apoptosis (610.1)
- HTLV-1 Tax stimulates ubiquitin E3 ligase, ring finger protein 8, to assemble lysine 63-linked polyubiquitin chains for TAK1 and IKK activation
- Hyaluronan induces MMP-9 secretion through FAK-IKK/IκBα pathways and 17-AAG down-regulates these pathways in human glioma cells
- Hydrogen peroxide has opposing effects on IKK activity and I κ B α breakdown in airway epithelial cells
- Hyper activation of β‐catenin signalling induced by IKK ε inhibition thwarts colorectal cancer cell proliferation
- Hypothalamic programming of systemic ageing involving IKK-β, NF-κB and GnRH
- Hypoxia activates IKK–NF-κB and the immune response in Drosophila melanogaster
- I-kappa-kinase-2 (IKK-2) inhibition potentiates vincristine cytotoxicity in non-Hodgkin’s lymphoma
- Icariin attenuates lipopolysaccharide-induced microglial activation and resultant death of neurons by inhibiting TAK1/IKK/NF-κB and JNK/p38 MAPK pathways
- Identification of Human IKK-2 Inhibitors of Natural Origin (Part I): Modeling of the
- Identification of human IKK-2 inhibitors of natural origin (part I): modeling of the IKK-2 kinase domain, virtual screening and activity assays
- Identification of human IKK-2 inhibitors of natural origin (Part II): in Silico prediction of IKK-2 inhibitors in natural extracts with known anti-inflammatory activity
- Identification of mutations in TRAPPC9, which encodes the NIK-and IKK-β-binding protein, in nonsyndromic autosomal-recessive mental retardation
- IDENTIFICATION OF NOVEL SUBSTRATE I-TRAF OF IKK-i KINASE
- Identification of plumericin from Himatanthus Sucuuba as a novel potent inhibitor of the NF-κB pathway directly targeting IKK-β
- IFIT5 positively regulates NF-κB signaling through synergizing the recruitment of IκB kinase (IKK) to TGF-β-activated kinase 1 (TAK1)
- IKK Alfred, Crosby-house, 95, Bishopsgate-street
- IKK alpha coordinates with RAS to switch well-differentiated papillomas to poorly differentiated malignant carcinomas in skin
- IKK alpha induces angiogenesis
- IKK alpha play an inhibitory role in malignant skin tumor progression
- IKK and (Beta)-Catenin in Breast Cancer
- IKK and Caspases in Regulating Cell Shape
- IKK and Diabetic Nephropathy [J]
- IKK and NF‐κB‐mediated regulation of Claspin impacts on ATR checkpoint function
- IKK antagonizes activation-induced cell death of CD4+ T cells in aged mice via inhibition of JNK activation
- IKK antagonizes CD95 ligation-mediated apoptosis by regulating NF-κB activity
- IKK at the 580 revolutions the “down” run was made
- IKK biology
- IKK Capt. Gabriel J., 6, Belsize-park, Hampstead
- IKK Charles Henry, 51, King’s-road, Camden-town
- IKK connects autophagy to major stress pathways
- IKK cuts both ways in Huntington’s disease
- IKK Electric F40LW-RS-WMII at approximately 1000
- IKK epsilon Deficiency Exacerbates Inflammation in the Absence of an Interferon Response in Murine Arthritis by Delaying Neutrophil Apoptosis
- IKK epsilon kinase is crucial for viral G protein-coupled receptor tumorigenesis
- IKK epsilon, STAT1, and IFIT2 define a novel innate immune effector pathway against West Nile virus infection
- IKK exceptional, viz. the temperature high and the air
- IKK expression as an immunohistochemical marker for diagnosis of high risk flat epithelial atypia (FEA) of the breast
- IKK Goes BAD
- IKK have not saved, and to bury them when
- IKK Henry Charles, 86, South-hill-park, Hampstead
- IKK inhibition by BMS-345541 suppresses breast tumorigenesis and metastases by targeting GD2+ cancer stem cells
- IKK inhibition increases bortezomib effectiveness in ovarian cancer
- IKK inhibition prevents PM2. 5-exacerbated cardiac injury in mice with type 2 diabetes
- IKK inhibitor PS1145 increases sensitivity of pancreatic cancer cells to TRAIL-induced apoptosis.
- IKK inhibitor suppresses epithelial-mesenchymal transition and induces cell death in prostate cancer
- IKK inhibitory activities of imidazo [1, 2-a] pyrazine, imidazo [1, 2-a] quinoxaline, imidazo [1, 5-a] quinoxaline and pyrazolo [1, 5-a] quinoxaline derivatives.
- IKK interacts with rictor and regulates mTORC2
- IKK is a therapeutic target in KRAS-induced lung cancer with disrupted p53 activity
- IKK jar of the previous dayforgiven, if not for
- IKK kinase assay for assessment of canonical NF-κB activation in neurons
- IKK Links the Steroid Receptor Coactivator to Immune Responses
- IKK low much or how little it surprised
- IKK M.-What is memory aging the aging of? Developmental Psychology. 1978, 14
- IKK mediates ischemia-induced neuronal death
- IKK my passage-money is more than I can
- IKK NBD peptide inhibits LPS induced pulmonary inflammation and alters sphingolipid metabolism in a murine model
- IKK of ease, and little alle
- IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome
- IKK phosphorylates RelB to modulate its promoter specificity and promote fibroblast migration downstream of TNF receptors
- IKK phosphorylation of NF-κB at serine 536 contributes to acquired cisplatin resistance in head and neck squamous cell cancer
- IKK Phosphorylation, ICAM–1, and CD11a/LFA–1 Increases Are Correlated With VEGF–Induced Blood–Retinal Barrier Breakdown and Are Blocked by Triamcinolone …
- IKK Proverb,” that he who i
- IKK regulates the deubiquitinase CYLD at the postsynaptic density
- IKK regulation and human genetics
- IKK results are included AAAAA
- IKK SCienCe
- IKK Targets PI3K
- IKK that the fact was not suspected in his life
- IKK the night and the morrow in that disa
- IKK The North Central High School, Spökano
- IKK to British subjects, residing at Zan
- IKK to us, nor could it have influenced our
- IKK were entitled to protection against this system of
- IKK with ebonite is shown in the following
- IKK with Mr. E, Jones, Hibernian Schools, Liver.
- IKK yearly by government auditor, and pub
- IKK α represses a network of inflammation and proliferation pathways and elevates c-Myc antagonists and differentiation in a dose-dependent manner in the …
- IKK β in postnatal perichondrium remotely controls endochondral ossification of the growth plate through downregulation of MCP-5
- IKK β inhibitor identification: a multi-filter driven novel scaffold
- IKK β programs to turn on the GADD45α/MKK4/JNKs apoptotic cascade specifically via p50 NF-κB in arsenite response
- IKK β regulates endothelial thrombomodulin in a Klf2‐dependent manner
- IKK β-targeted anti-inflammatory activities of a butanol fraction of artificially cultivated Cordyceps pruinosa fruit bodies
- IKK-±: An Alternative Player In Inflammation-Induced Loss Of Muscle Oxidative Phenotype In COPD?
- IKK-1 and IKK-2: cytokine-activated IκB kinases essential for NF-κB activation
- IKK-2
- IKK-2 inhibitor TPCA-1 represses nasal epithelial inflammation in vitro.
- IKK-2 is required for TNF-α-induced invasion and proliferation of human mesenchymal stem cells
- IKK-2/NF-κB-DEPENDENT TRANSCRIPTION
- IKK-alpha PROTEIN, NUCLEIC ACID ENCODING THE SAME AND METHOD
- IKK-and NF-κB-mediated functions in carcinogenesis
- IKK-Beta Deletion Alleviates the Atherogenetic Effect of Intermittent Hypoxia Induced Macrophage Foam Cell Formation
- IKK-dependent activation of NF-κB contributes to myeloid and lymphoid leukemogenesis by BCR-ABL1
- IKK-dependent, NF-κB-independent control of autophagic gene expression
- IKK-epsilon contributes to the malignant progression of ovarian cancer
- IKK-Epsilon, a novel factor identified by proteomics, contributes to prostate cancer cell-induced osteoclast activity in vitro.
