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Gossypol Exercise prevents diet-induced cellular senescence in adipose tissue Physiological aging: links among adipose tissue dysfunction, diabetes, and frailtyUnbiased analysis of senescence associated secretory phenotype (SASP ) to identify common components following different genotoxic stressesAging and adipose tissue : potential interventions for diabetes and regenerative medicineRoles of chemokine ligand-2 (CXCL2) and neutrophils in influencing endothelial cell function and inflammation of human adipose tissue Ablation of XP-V gene causes adipose tissue senescence and metabolic abnormalitiesThe emerging role of senescent cells in tissue homeostasis and pathophysiology Cellular senescence and the senescent secretory phenotype in age-related chronic diseases JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age Growth hormone action predicts age-related white adipose tissue dysfunction and senescent cell burden in miceAging-related inflammation in osteoarthritis Cellular senescence in type 2 diabetes: a therapeutic opportunity The fat cell senescence hypothesis: a mechanism responsible for abrogating the resolution of inflammation in chronic disease Feast and famine: adipose tissue adaptations for healthy agingMacrophages in age-related chronic inflammatory diseases Proposed metabolic vicious circle in patients with large myocardial infarcts and high plasma-free-fatty-acid concentrations Perspective: targeting the JAK/STAT pathway to fight age-related dysfunction Effect of low-dose rapamycin on senescence markers and physical functioning in older adults with coronary artery disease: results of a pilot study. Systemic DNA damage response and metabolic syndrome as a premalignant state Stem cell senescence and regenerative paradigms Cellular senescence in ageing, age-related disease and longevity Contribution of adipose tissue inflammation to the development of type 2 diabetes mellitusPhytochemicals suppress nuclear factor-κB signaling: impact on health span and the aging process Effect of lipopolysaccharides on adipogenic potential and premature senescence of adipocyte progenitors Developments in our understanding of the effects of growth hormone on white adipose tissue from mice: implications to the clinicCellular senescence in aging and age-related disease: from mechanisms to therapy Deleted in B reast C ancer 1 regulates cellular senescence during obesity Growth differentiation factor 6 derived from mesenchymal stem/stromal cells reduces age-related functional deterioration in multiple tissues Mitochondrial dysfunction induces senescence with a distinct secretory phenotype Impact of growth hormone on regulation of adipose tissue Senescence-associated secretory phenotype (SASP ) involvement in the development of cancer, aging, and age related diseasesClearance of p16Ink4a-positive senescent cells delays ageing-associated disorders Curcumin, inflammation, ageing and age-related diseases Inflammation, ageing and chronic disease Geroscience: linking aging to chronic disease Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!) Mitochondrial dysfunction meets senescence Finding Shangri-La: limiting the impact of senescence on aging Inflamm-ageing Characterization of senescence of culture-expanded human adipose-derived mesenchymal stem cells An experiment to determine the active therapeutic moiety of sulphasalazine Aging of the human innate immune system in HIV infection Metabolic syndrome is a real disease and premalignant state induced by oncogenic stresses to block malignant transformation Mechanisms and metabolic implications of regional differences among fat depots The role of inflammation in age-related disease “Inflammaging” as a druggable target: a senescence-associated secretory phenotype—centered view of type 2 diabetes Antagonizing Effects of Aspartic Acid against Ultraviolet A-Induced Downregulation of the Stemness of Human adipose tissue -Derived Mesenchymal Stem …Cellular senescence: from physiology to pathology RETRACTED: Chronic Inflammation: Accelerator of Biological Aging Senescence associated macrophages and “macroph-aging”: are they pieces of the same puzzle? Cellular senescence and the biology of aging, disease, and frailty Targeting senescent cells enhances adipogenesis and metabolic function in old age Urinary Iodine Concentrations in Mothers and their Term Newborns Aging and osteoarthritis Obesity-associated mechanisms of hepatocarcinogenesis P12 Pathological vascular smooth muscle cells remodelling in murine models of abdominal aortic aneurysm The aging adipose organ: lipid redistribution, inflammation, and cellular senescence Ginsenoside Rd attenuates the inflammatory response via modulating p38 and JNK signaling pathways in rats with TNBS-induced relapsing colitis Impact of cellular senescence signature on ageing research Metabolic and microenvironment changes in the mammary of calorie restricted, normal weight, and obese mice throughout the lifespan Senescent cells: a novel therapeutic target for aging and age‐related diseases … and Metabolic Dysfunction during Aging and Senescence: Effect of lipopolysaccharides on adipogenic potential and premature senescence of adipocyte … Crossing Boundaries to Propel Tissue Engineering into the Clinic Mitochondrial damage induces senescence with a twisted arm Therapeutic effect and mechanism of proanthocyanidins from grape seeds in rats with TNBS-induced ulcerative colitis Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases Pathogenesis of hepatocellular carcinoma development in non-alcoholic fatty liver disease ÔØ Å ÒÙ× Ö ÔØ Aging of the immune system: focus on inflammation and vaccination Molecular mechanisms of ageing and related diseases Senescent cells: SASP ected drivers of age-related pathologiesControl of p53 and NF-κB signaling by WIP1 and MIF: role in cellular senescence and organismal aging p21 both attenuates and drives senescence and aging in BubR1 progeroid mice Stop feeding cancer: pro-inflammatory role of visceral adiposity in liver cancer Cellular senescence and the senescent secretory phenotype: therapeutic opportunities Metabolic control of longevity Cisplatin-induced mesenchymal stromal cells-mediated mechanism contributing to decreased antitumor effect in breast cancer cells Microbiome–Obesity–Liver Cancer Interaction: Senescence of Hepatic Stellate Cells and Bile Acids Play New Roles Ameliorative effects of 3, 4-oxo-isopropylidene-shikimic acid on experimental colitis and their mechanisms in rats Hepatocellular carcinoma and lifestyles Inflammation and cellular senescence: potential contribution to chronic diseases and disabilities with aging Toll like receptor signaling in “inflammaging”: microRNA as new players Depleting senescent cells to combat aging www. aging-us. com AGING 2016, Vol. 8, Advance High-throughput screening reveals enzyme and GPCR targets as putative binding sites for d-deprenyl Adipocytes and neutrophils give a helping hand to pancreatic cancers Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice Anti-inflammatory effects of Pulvis Fellis Suis extract in mice with ulcerative colitis Ageing and the pathogenesis of osteoarthritis Aging of mice is associated with p16 (Ink4a)-and β-galactosidase-positive macrophage accumulation that can be induced in young mice by senescent cells Cellular senescence in aging and osteoarthritis: implications for cartilage repair Oxidative stress and the ageing endocrine system Clinical strategies and animal models for developing senolytic agents Liver cancer: connections with obesity, fatty liver, and cirrhosis Of flies, mice, and men: evolutionarily conserved tissue damage responses and aging Age-dependent dysregulation of innate immunity Endothelial progenitor cells: from senescence to rejuvenation Aging: a common driver of chronic diseases and a target for novel interventions Increased IL-6 secretion by aged human mesenchymal stromal cells disrupts hematopoietic stem and progenitor cells’ homeostasis Extracellular microRNAs and endothelial hyperglycaemic memory: a therapeutic opportunity? The role of oxidative stress and inflammation in cardiovascular aging Cell autonomous and non-autonomous effects of senescent cells in the skin A case of rheumatoid arthritis exhibiting accelerating rheumatoid pleurisy during low-dose weekly methotrexate therapy Mesenchymal stroma: primary determinant and therapeutic target for epithelial cancer The role of senescent cells in ageing Sowing the seeds of cancer: telomeres and age-associated tumorigenesis Tim-3: an emerging target in the cancer immunotherapy landscape Effect of traditional Chinese medicinal enemas on ulcerative colitis of rats Diabetes and cancer, common threads and missing links Hepatocellular carcinoma in nonalcoholic fatty liver: role of environmental and genetic factors Translational research in immune senescence: assessing the relevance of current models Elimination of p19ARF-expressing cells enhances pulmonary function in mice The effects of aging on the development of osteoarthritis Cellular senescence impact on immune cell fate and function Effects of proanthocyanidins from grape seed on treatment of recurrent ulcerative colitis in rats Proanthocyanidins from grape seeds modulate the NF-κB signal transduction pathways in rats with TNBS-induced ulcerative colitis Morphological, molecular and functional differences of adult bone marrow-and adipose-derived stem cells isolated from rats of different ages The role of insulin resistance in nonalcoholic steatohepatitis and liver disease development–a potential therapeutic target? Nonalcoholic fatty liver disease: pathogenesis and disease spectrum The possible mechanisms of Picrasma quassiodes (D. Don) Benn. in the treatment of colitis induced by 2, 4, 6-trinitrobenzene sulfonic acid in mice Aldosterone induces p21‐regulated apoptosis via increased synthesis and secretion of tumour necrosis factor‐α in human proximal tubular cells Senescence as a general cellular response to stress: a mini-review Obesity and liver cancer Cell senescence abrogates the therapeutic potential of human mesenchymal stem cells in the lethal endotoxemia model Reversing multiple age-related pathologies by controlling the senescence-associated secretory phenotype of stem cells Histone macroH2A1. 2 promotes metabolic health and leanness by inhibiting adipogenesis Pivotal role of Sirt6 in the crosstalk among ageing, metabolic syndrome and osteoarthritis Proanthocyanidins from grape seeds modulates the nuclear factor-kappa B signal transduction pathways in rats with TNBS-induced recurrent ulcerative colitis Maternal obesity programs senescence signaling and glucose metabolism in osteo-progenitors from rat and human Immunosurveillance of senescent cells: the bright side of the senescence program Obesity and the gut microbiome: pathophysiological aspects Ageing induced vascular smooth muscle cell senescence in atherosclerosis Cancer and inflammation: an old intuition with rapidly evolving new concepts Obesity and cancer pathogenesis Metabolic consequences of HIV: pathogenic insights Noncoding RNA control of cellular senescence Protective effects of 3, 4-oxo-isopropylidene-shikimic acid on experimental colitis induced by trinitrobenzenesulfonic acid in rats Inflammaging decreases adaptive and innate immune responses in mice and humans Senescence and the pro-tumorigenic stroma Siegesbeckia pubescens ameliorates experimental ulcerative colitis in rats by modulating PPARγ. Therapeutic effect of ginsenoside Rd in rats with TNBS-induced recurrent ulcerative colitis Mice deficient in Rbm38, a target of the p53 family, are susceptible to accelerated aging and spontaneous tumors Serum n3 polyunsaturated fatty acids are depleted in Crohn’s disease The cell secretome, a mediator of cell-to-cell communication Targeting senescent cells: possible implications for delaying skin aging: a mini-review DNA damage and innate immunity: links and trade-offs The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs Protective effect of taurohyodeoxycholic acid from Pulvis Fellis Suis on trinitrobenzene sulfonic acid induced ulcerative colitis in mice Chronic inflammation, immune escape, and oncogenesis in the liver: a unique neighborhood for novel intersections Mesenchymal stem cells in regenerative medicine: focus on articular cartilage and intervertebral disc regeneration Interventions to slow aging in humans: are we ready? Anti-inflammatory activity and mechanisms of a lipid extract from hard-shelled mussel (Mytilus coruscus) in mice with dextran sulphate sodium-induced colitis DNA damage response and autophagy: a meaningful partnership NF-κB pathway activators as potential ageing biomarkers: targets for new therapeutic strategies mTOR signaling from cellular senescence to organismal aging Erdheim–Chester disease: from palliative care to targeted treatment Gerosuppressant metformin: less is more Chemoprevention of obesity-related liver carcinogenesis by using pharmaceutical and nutraceutical agents Workshop report Key data from the 11th International Workshop on Adverse Drug Reactions and Co-Morbidities in HIV Human mesenchymal stem cell-replicative senescence and oxidative stress are closely linked to aneuploidy Immune aging, dysmetabolism, and inflammation in neurological diseases Anti-inflammatory effects of Huangqin tang extract in mice on ulcerative colitis Conditioned media from human umbilical cord blood-derived mesenchymal stem cells inhibits melanogenesis by promoting proteasomal degradation of MITF Speeding up the clock: The past, present and future of progeria Mathematical integration of protein metabolism in growing lambs Short telomeres in key tissues initiate local and systemic aging in zebrafish Modelling age-related metabolic disorders in the mouse Disease drivers of aging Myeloma cells can corrupt senescent mesenchymal stromal cells and impair their anti-tumor activity Diabetes and aging Exercise attenuates the major hallmarks of aging Long noncoding RNAs in diseases of aging Evolving concepts in the pathogenesis of NASH: beyond steatosis and inflammation From cell senescence to age-related diseases: differential mechanisms of action of senescence-associated secretory phenotypes Persistent DNA damage‐induced premature senescence alters the functional features of human bone marrow mesenchymal stem cells Halofuginone reduces the inflammatory responses of DSS-induced colitis through metabolic reprogramming Obesity and cancer Senescence in human mesenchymal stem cells: functional changes and implications in stem cell-based therapy Bile acids and the gut microbiome Aging, clonality, and rejuvenation of hematopoietic stem cells Dysregulated inflammation as a risk factor for pneumonia in the elderly Ageing and the telomere connection: An intimate relationship with inflammation The study of skeletal aging is coming of age: A forum on aging and skeletal health Resveratrol attenuates senescence of adipose-derived mesenchymal stem cells and restores their paracrine effects on promoting insulin secretion of INS-1 … Cancer-associated-fibroblasts and tumour cells: a diabolic liaison driving cancer progression Nuclear lamina defects cause ATM-dependent NF-κB activation and link accelerated aging to a systemic inflammatory response SYSTEMIC DNA DAMAGE RESPONSE AND METABOLIC SYNDROME Secreted microvesicular miR‐31 inhibits osteogenic differentiation of mesenchymal stem cells Are there roles for brain cell senescence in aging and neurodegenerative disorders? Effect of Manuka honey and sulfasalazine in combination to promote antioxidant defense system in experimentally induced ulcerative colitis model in rats Effect of hyperglycemia on hepatocellular carcinoma development in diabetes NF-κB in aging and disease Toward the comprehensive understanding of the gut ecosystem via metabolomics-based integrated omics approach Interleukin‐8 production in tuberculous pleurisy: role of mesothelial cells stimulated by cytokine network involving tumour necrosis factor‐α and interleukin‐1β Energetic interventions for healthspan and resiliency with aging Secretome of human fetal mesenchymal stem cell ameliorates replicative senescence Caloric restriction and aging stem cells: the stick and the carrot? Exercise enhances wound healing and prevents cancer progression during aging by targeting macrophage polarity The promise of slow down ageing may come from curcumin Effects of mimic of manganese superoxide dismutase on 2, 4, 6-trinitrobenzene sulfonic acid-induced colitis in rats Genome-wide chromatin state transitions associated with developmental and environmental cues Oxidative stress, cellular senescence and ageing 7 Immune Senescence What Is Homeostasis? Atypical pyoderma gangrenosum with leukemia INVESTIGATING MOLECULAR PATHWAYS OF ROS-INDUCED PRO-INFLAMMATORY SENESCENCE IN PREADIPOCYTES Vascular wall-resident multipotent stem cells of mesenchymal nature within the process of vascular remodeling: cellular basis, clinical relevance, and … Recombinant HSP70 and mild heat shock stimulate growth of aged mesenchymal stem cells Senescence in chronic obstructive pulmonary disease Fibrogenesis and carcinogenesis in nonalcoholic steatohepatitis (NASH): involvement of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinase … Non-alcoholic steatohepatitis and hepatocellular carcinoma: implications for lycopene intervention Telomeres and age-related disease: how telomere biology informs clinical paradigms Characterization of the human salivary proteome by capillary isoelectric focusing/nanoreversed-phase liquid chromatography coupled with ESI-tandem MS Macromolecular degradation systems and cardiovascular aging Acute phase serum amyloid A induces proinflammatory cytokines and mineralization via toll-like receptor 4 in mesenchymal stem cells Identification of a novel senolytic agent, navitoclax, targeting the Bcl‐2 family of anti‐apoptotic factors Understanding The Regulation Of Adipogenesis And Adipocyte Metabolism In Obesity Reprogramming suppresses premature senescence phenotypes of Werner syndrome cells and maintains chromosomal stability over long-term culture The senescence arrest program and the cell cycle The posttranslational processing of prelamin A and disease Caveolae and signalling in cancer Therapy with multipotent mesenchymal stromal cells protects lungs from radiation-induced injury and reduces the risk of lung metastasis Frailty and sarcopenia as the basis for the phenotypic manifestation of chronic diseases in older adults From experimental design to functional gene networks: DNA microarray contribution to skin ageing research Senescence-associated MCP-1 secretion is dependent on a decline in BMI1 in human mesenchymal stromal cells Tumour biology of obesity-related cancers: understanding the molecular concept for better diagnosis and treatment Protective effect of sanguinarine against acetic acid-induced ulcerative colitis in mice Living Large: What Mouse Models Reveal about Growth Hormone and Obesity Signaling networks determining life span Invariant natural killer T cells recognize a fungal glycosphingolipid that can induce airway hyperreactivity The second international conference “genetics of aging and longevity” Amniotic epithelial cells: a new tool to combat aging and age-related diseases? Mesenchymal stem cells in wound repair, tissue homeostasis, and aging The role and regulation of the nuclear factor kappa B signalling pathway in human labour Physiological regulation of the heat shock response by glutamine: implications for chronic low-grade inflammatory diseases in age-related conditions At the stem of youth and health New Insights into the Management and Therapeutics of Type 2 Diabetes Epigallocatechin-3-gallate ameliorates rats colitis induced by acetic acid Cellular and molecular biology of aging endothelial cells The nuclear lamina in health and disease The Biology of Aging: Role in Cancer, Metabolic Dysfunction, and Health Disparities Cellular and molecular basis of the imbalance between vascular damage and repair in ageing and age-related diseases: as biomarkers and targets for new … Interrater reliability of a clinical scale to assess knee joint effusion Telomeres, oxidative stress and inflammatory factors: partners in cellular senescence? Cell cycle arrest and the evolution of chronic kidney disease from acute kidney injury Biomarkers and Inflammatory Network in Aging: Targets for Therapies Implications of multipotent mesenchymal stromal cell aging Connecting the dots: from DNA damage and repair to aging Metformin‐mediated increase in DICER1 regulates microRNA expression and cellular senescence MicroRNA-34a induces endothelial progenitor cell senescence and impedes its angiogenesis via suppressing silent information regulator 1 Identification of senescent cells in the bone microenvironment Identification of microRNAs dysregulated in cellular senescence driven by endogenous genotoxic stress Melatonin and the theories of aging: a critical appraisal of melatonin’s role in antiaging mechanisms Increasing longevity through caloric restriction or rapamycin feeding in mammals: common mechanisms for common outcomes? Extracellular microRNAs and endothelial hyperglycemic memory: a therapeutic opportunity? Skin mirrors human aging miR‐335 correlates with senescence/aging in human mesenchymal stem cells and inhibits their therapeutic actions through inhibition of AP‐1 activity Effect of different doses of Manuka honey in experimentally induced inflammatory bowel disease in rats Illuminating inflammasome activity in vivo Metabolic exchanges within tumor microenvironment Inflammation and atherosclerosis in rheumatoid arthritis From cellular senescence to age-associated diseases: the miRNA connection Melatonin reduces endoplasmic reticulum stress and autophagy in liver of leptin‐deficient mice Modulation of Membrane Transport Systems The role of chromatin reorganization in the process of cellular senescence Pleiotropic effects of tocotrienols and quercetin on cellular senescence: introducing the perspective of senolytic effects of phytochemicals Role of DNA damage in cardiovascular disease The telomere syndromes Somatic stem cell aging and malignant transformation–impact on therapeutic application Organelle Stress and mTOR in Aging-Associated Inflammation ACC 284 Regulatory roles of miRNAs in aging Evidences of early senescence in multiple myeloma bone marrow mesenchymal stromal cells Mechanisms of metastatic tumor dormancy Liposarcoma Liposarcomas-proliferation, senescence and the role of DDIT3 Senescence bypass in mesenchymal stem cells: a potential pathogenesis and implications of pro-senescence therapy in sarcomas Mechanisms of resveratrol-induced inhibition of clonal expansion and terminal adipogenic differentiation in 3T3-L1 preadipocytes Progressive loss of SIRT1 with cell cycle withdrawal Targeting Senescent Cells to Improve Human Health Defining mesenchymal stromal cells responsiveness to IFNγ as a surrogate measure of suppressive potency The germline/soma dichotomy: implications for aging and degenerative disease Identifying of the causative genes in spontaneous mutant mouse strains by forward-reverse genetics Phenylbutyric Acid: simple structure-multiple effects The role of immunosenescence in the development of age-related diseases Melatonin reverses H2O2‐induced premature senescence in mesenchymal stem cells via the SIRT1‐dependent pathway Recent advances in mouse models of obesity-and nonalcoholic steatohepatitis-associated hepatocarcinogenesis Cellular senescence and vascular disease: novel routes to better understanding and therapy Telomeres, NAFLD and chronic liver disease The emergence of geromirs: A group of micrornas implicated in aging The Role of Stem Cell Genomic Instability in Aging Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic … Regulation of senescence by microRNA biogenesis factors Host resistance and immune aging Coming of age: molecular drivers of aging and therapeutic opportunities ISSN 0975-413X CODEN (USA): PCHHAX Finding Ponce de Leon’s Pill: challenges in screening for anti-aging molecules Thymic involution perturbs negative selection leading to autoreactive T cells that induce chronic inflammation An Arf-Egr-C/EBPβ pathway linked to ras-induced senescence and cancer Growth hormone is a cellular senescence target in pituitary and nonpituitary cells MicroRNAs linking inflamm-aging, cellular senescence and cancer Ionizing radiation promotes the acquisition of a senescence-associated secretory phenotype and impairs angiogenic capacity in cerebromicrovascular endothelial … Medial arterial calcification: an overlooked player in peripheral arterial disease Lessons from Hepatocyte-Specific Cyp51 Knockout Mice: Impaired Cholesterol Synthesis Leads to Oval Cell-Driven Liver Injury Senescence-associated secretory phenotype contributes to pathological angiogenesis in retinopathy Inflammasomes: guardians of cytosolic sanctity As we age: Does slippage of quality control in the immune system lead to collateral damage? Anti-aging pharmacology: promises and pitfalls Neovascularization capacity of mesenchymal stromal cells from critical limb ischemia patients is equivalent to healthy controls Effect of hyperglycemia on hepatocellular carcinoma development in diabetes Expression of HOXD9 in fibroblast-like synoviocytes from rheumatoid arthritis patients The Disrupted Steady-State: Tipping the Balance in Favour of Cancer The Way Forward: Translation Intervention of aging and its effects on cellular health DNA damage response and immune defense: links and mechanisms Towards an evidence-based model of aging iPSCs as a major opportunity to understand and cure age-related diseases The biology of aging: 1985–2010 and beyond DNA damage: from chronic inflammation to age-related deterioration The emerging role of Notch pathway in ageing: focus on the related mechanisms in age-related diseases SPEAKER ABSTRACTS miR-29c-3p promotes senescence of human mesenchymal stem cells by targeting CNOT6 through p53–p21 and p16–pRB pathways Osteopontin, a key mediator expressed by senescent pulmonary vascular cells in pulmonary hypertension NF-κB signaling as a driver of ageing The Cellular Senescence Program Age-related changes in blood-brain barrier integrity in C57BL/6J mice Ultrastructural analysis of changes in neurons of the mouse internal anal sphincter during ageing Age-related changes to lumbosacral spinal cord motoneurons that modulate bladder and bowel functions in male C57BL/6 mice The metabolic regulation of cellular ageing The inflammatory network: bridging senescent stroma and epithelial tumorigenesis Cellular senescence and inflammation in aging and age-related disease Influence of aging on the quantity and quality of human cardiac stem cells Prospects and challenges for the use of stem cell technologies to develop novel therapies for Parkinson disease Hypoxia-inducible histone lysine demethylases: impact on the aging process and age-related diseases Autophagy and cancer metabolism Assessing cell and organ senescence biomarkers Sphingolipids in inflammation: pathological implications and potential therapeutic targets ÔØ Å ÒÙ× Ö ÔØ Metformin and the ATM DNA damage response (DDR): accelerating the onset of stress-induced senescence to boost protection against cancer Cellular senescence in cardiovascular diseases: potential age-related mechanisms and implications for treatment Insulin-like growth factor binding proteins 4 and 7 released by senescent cells promote premature senescence in mesenchymal stem cells Pathogenesis of osteoarthritis Better living through chemistry: caloric restriction (CR) and CR mimetics alter genome function to promote increased health and lifespan Perspectives on translational and therapeutic aspects of SIRT1 in inflammaging and senescence Intestinal anti-inflammatory effect of the rhizome extracts of Menispermum dauricum DC. on trinitrobenzene sulfonic acid induced ulcerative colitis in mice Biosprays: From the biomedical to the clinical sciences Influence of age and physical fitness on miRna-21, TGF-ß and its receptors in leukocytes of healthy women. Caspase inhibition switches doxorubicin-induced apoptosis to senescence MicroRNAs as mediators of the ageing process Modelling ageing and age-related disease PROTECTIVE EFFECT OF RICE BRAN WATER EXTRACT ON PANCREAS OF RATS FED A HIGH-FAT DIET New objective findings after whiplash injuries: high blood flow in painful cervical soft tissue: an ultrasound pilot study Genome integrity in aging: human syndromes, mouse models, and therapeutic options Conditioned medium derived from rat amniotic epithelial cells confers protection against inflammation, cancer, and senescence Endothelial cell senescence and thrombosis: ageing clots A Fungal Glycosphingolipid Directly Activates Natural Killer T Cells and Rapidly Induces Airways Disease NAFLD and hepatocellular Carcinoma: how big a problem is this really? Mast cells and histamine are triggering the NF-κB-mediated reactions of adult and aged perilymphatic mesenteric tissues to acute inflammation Oral submucous fibrosis: Review on mechanisms of pathogenesis and malignant transformation Extracellular vesicles in lung microenvironment and pathogenesis Vascular endothelial senescence: from mechanisms to pathophysiology Autoimmune atherosclerosis in 3D: how it develops, how to diagnose and what to do Physiological roles of the DNA demethylation-associated proteins Gadd45a and Ing1 Stress-induced premature senescence of endothelial and endothelial progenitor cells Regulation of Senescence by microRNAs Muscle stem cell aging: regulation and rejuvenation kk journal of experimental biology. 2.20 Behcet’s disease and miscellaneous rheumatic conditions Inflammatory bowel disease part I: ulcerative colitis–pathophysiology and conventional and alternative treatment options The Buck Institute: An inside look Accelerated epithelial cell senescence in IPF and the inhibitory role of SIRT6 in TGF-β-induced senescence of human bronchial epithelial cells Orphan technology: Unfunded early-stage bioscience is dropped off at the firehouse Computational approaches for the transcriptomics, proteomics and epigenetic analysis in adult stem cells The secret lives of stem cells: Unraveling the molecular basis of stem cell aging Positive and negative effects of cellular senescence during female reproductive aging and pregnancy Global profiling and relative quantifiction of histones, histone PTMs and histone-modifying enzymes in mesenchymal stem cells using LC-MS/MS and a novel … The 10th World Congress on Inflammation Ms. No.: METHODS-D-15-00125 R1–Revised Version Are aging biomarkers clinically relevant in oncogeriatrics? Apocrine secretion: new insights into an old phenomenon Molecular links between cellular senescence, longevity and age-related diseases–a systems biology perspective Practical Laboratory Medicine Stop Aging Disease! ICAD 2014. PROGRESS REPORT ON THE ROLE OF MITOCHONDRIAL ISOCITRATE DEHYDROGENASE 2 IN AGE-RELATED HEARING LOSS IN MICE Impact of physical activity on immune function and inflammation in the elderly Four faces of cellular senescence Interventions to slow aging in humans: Are we ready? Determination of serum visfatin level in patients with Behcet disease, comparing with normal population Senescent fibroblast-derived Chemerin promotes squamous cell carcinoma migration DNA damage: a main determinant of vascular aging The Role of Estrogen Deficiency in Skin Aging and Wound Healing Comparative analysis of gene expression data reveals novel targets of senescence-associated microRNAs Accelerated telomere shortening in acromegaly; IGF-I induces telomere shortening and cellular senescence Salvianolic acid B restored impaired barrier function via downregulation of MLCK by microRNA-1 in rat colitis model IL-6 and related cytokines as the critical lynchpins between inflammation and cancer Anti-stress gene response in cell and tissue ageing: role of transcription factor NF-E2-related factor-2 and effect of dietary activators Protective Effect of Paronychia argentea L. on Acetic Acid Induced Ulcerative Colitis in Mice by Regulating Antioxidant Parameters and Inflammatory Markers 7th Joint Meeting of the European Tissue Repair Society (ETRS) with the Wound Healing Society Human Amniotic Fluid Mesenchymal Stromal cells (AF-MSCs) are Less Prone to in vitro Senescence Process Compared with Bone Marrow MSCs The central role of muscle stem cells in regenerative failure with aging Modulation of ageing characteristics with an anti-ageing compound Insulin pathway and its correlation with ageing and longevity Glucocorticoids suppress selected components of the senescence‐associated secretory phenotype Altered glycolipid and glycerophospholipid signaling drive inflammatory cascades in adrenomyeloneuropathy Stem cells and cancer stem cells Nutritional Modulators of Cellular Senescence In Vitro Non‐cell autonomous or secretory tumor suppression The Aging Superorganism Systemic problems: a perspective on stem cell aging and rejuvenation Modulators of cellular senescence: mechanisms, promises, and challenges from in vitro studies with dietary bioactive compounds Pharmacotherapeutics ECG of the Month Molecular Mechanisms of Lycopene Actions on Liver Disease Outcomes Pathophysiological fundamentals of diabetic cardiomyopathy The gut microbial endocrine organ: bacterially derived signals driving cardiometabolic diseases The role of miRNAs in common inflammatory arthropathies: osteoarthritis and gouty arthritis Similarities in gene expression profiles during in vitro aging of primary human embryonic lung and foreskin fibroblasts Rescuing the regenerative capacity of human mesenchymal stem cells from the elderly Nuclear lamina defects cause ATM-dependent NF-κB activation and link accelerated aging to a systemic inflammatory response Nuclear lamina defects cause ATM-dependent NF Interventions for age-related diseases: Shifting the paradigm An Arf-Egr-C Biomolecular bases of the senescence process and cancer. A new approach to oncological treatment linked to ageing Aging, Immunosenescence, and Cancer A causal role of ATM-and NEMO-dependent NF-κB activation in DNA damage-induced senescence and aging Effect of bisphenol A on stress-induced premature senescence Progerin Expression Disrupts Critical Adult Stem Cell Functions that Mediate Tissue Repair Primarily through a Mechanism that Permanently Farnesylates Lamin A Systemic DNA damage responses in aging and diseases Osteoarthritis in the Elderly MDM2 levels modulate the cellular senescence response to CDK4 inhibition Functional-structural plant modeling Placental origins of chronic disease Inflammatory dysregulation and cancer: From molecular mechanisms to therapeutic opportunities The Role of Integrated Omics in Elucidating the Gut Microbiota Health Potentials Allogeneic mesenchymal stem cells transplantation in patients with refractory RA Stress-Induced Senescence: Molecular Pathways Neovascularization capacity of mesenchymal stromal cells from critical limb ischemia patients is equivalent to healthy controls Twist proteins as oxidative and hypoxic stress regulators The gut microbiota and the liver: implications for clinical practice The Epigenome and Aging Protein expression analysis of rat testes induced testicular toxicity with several reproductive toxicants Glenn Workshop on the Biology of Aging and AFAR Grantee Conference| JOINT MEETING The hallmarks of fibroblast ageing Signaling Networks Controlling Cellular Senescence Evidences of Early Senescence in Multiple Myeloma Bone Marrow Systemic administration of WY-14643, a selective synthetic agonist of peroxisome proliferator activator receptor-alpha, alters spinal neuronal firing in a rodent model of … Development of a mouse model for Hutchinson-Gilford progeria syndrome reveal defects in adult stem cell maintenance A potential role for miR-31 in osteoblastic transition of vascular smooth muscle cells and cortisol-induced osteoporosis Senescent mesenchymal stem cells promote colorectal cancer cells growth via galectin-3 expression BLT2 Protects Skin from the Damage Caused by Type 2 Diabetes Hyperglycemia by Increasing NO Production Through the nNOS Expression Molecular mechanisms of aging in MTDNA mutator mice Reversing stem cell aging: Implications for vascular regeneration Targeting the tumor stroma as a novel therapeutic approach for prostate cancer The Role of Macrophage Migration Inhibitory Factor in Osteoarthritis Evidence supporting the utility of blood cell respiratory capacity as a systemic marker of mitochondrial health and biological age Circadian molecular clock in lung pathophysiology Stop Aging Disease! ICAD 2014 Investigating the differential instructive roles of WT1’s isoforms Osteoporosis and mechanisms of skeletal aging Functional Enrichment Analysis mberHappily (n) ever after: Aging in the context of oxidative stress, proteostasis loss and cellular senescence Skin disease in laminopathy-associated premature aging Cellular and Molecular Mechanisms of Chronic Inflammation in Aging of Skeletal Muscle Oxidative stress-induced JNK activation contributes to proinflammatory phenotype of aging diabetic mesangial cells Histone methylation and aging: lessons learned from model systems Regulation of Phospholipase Isozymes by Nuclear Factor-κB in Human Gestational Tissues in Vitro Fluorescence Spectroscopy Psoriasis and inflammatory bowel disease: links and risks Prelamin A accelerates vascular calcification via activation of the DNA damage response and senescence-associated secretory phenotype in vascular smooth muscle … SIRT1 in endothelial cells as a novel target for the prevention of early vascular aging Cellular senescence as the causal nexus of aging MicroRNAs Regulate p21Waf1/Cip1 Protein Expression and the DNA Damage Response in Human Embryonic Stem Cells Basic Research Nuclear matrix, nuclear envelope and premature aging syndromes in a translational research perspective Relationships Among Body Mass Index, Nutrition, Internalizing Symptoms, and Ethnic Identity of Cherokee Youth Attending a Private American Indian Secondary … The role of the stress response gene Gadd45b in senescence False discovery rate (FDR) FBA Analysis, Plant-Pathogen Interactions Influence of aging on proliferation, pluripotency, immunogenic profiles from bone marrow mesenchymal stem cells Macrophage migration inhibitory factor regulates AKT signaling in hypoxic culture to modulate senescence of human mesenchymal stem cells Cell and molecular aging Loss of HuR leads to senescence-like cytokine induction in rodent fibroblasts by activating NF-κB Role of the nuclear envelope in regulation of ageing Chemotherapy-and Radiation-Induced Accelerated Senescence: Implications for Treatment Response, Tumor Progression and Cancer Survivorship Selenium and Senescence: Centering on Genome Maintenance Author statement Mechanisms of action of anti-TNF-α antibodies in inflammatory bowel disease Immortality: Myth or becoming Reality Skin, Mucosa and Menopause SUPPLEMENTARY TABLES Proteome analysis of formalin-fixed and paraffin-embedded tissue Framework Region (FR-IMGT) Frequent Pattern Mining Founders Effect Fisher’s Test Frequency Frequentist Approach Fitness Forward-scattered Light (FSC) Fluorescent Markers Fluorescence Microscopy Functional/Signature Network Module for Target Pathway/Gene Discovery Forward and Inverse Parameter Estimation for Metabolic Models Feature Selection Fitness Function Feedback Regulation Fibroblasts Feasibility Functional Modules and Complexes FunctionalityType Flux Balance Analysis Fokker–Planck Equation Faceted Browsing Fluorescence-activated Cell Sorting Flow Cytometry Frame Language Function, biological Feed Forward Loop Fluorophore Fluorescence Microscope False Positive Rate Fuzzy Logic Functional Flux Control Coefficient Fluorescence Functor Fourier Transform Infrared Microspectroscopy (FTIR) FuGE Foundational Model of Anatomy Floquet Multiplier Function, Distributed 9.1 Gut Microbiota Ageing and inflammation with focus on end-stage renal diseases: genetic and epigenetic factors The pleiotropic effects of HMG-CoA reductase inhibitors in inflammatory arthritis Assessing Pain and Inflammation in Arthritis Using Novel Imaging Methods The skin as a mirror of the aging process Hyperalgesia and allodynia to superficial and deep-tissue mechanical stimulation within and outside of the UVB irradiated area in human skin IL-6 secreted from senescent mesenchymal stem cells promotes proliferation and migration of breast cancer cells The role of telomere damage in cardiomyocyte ageing Gut Microbiota and HCC Contributions of telomere biology to human age-related disease Adult cardiac stem cells: identity, location and potential Human Population Studies of Transcriptome-wide Expression in Age-related Traits The Role of Age in Cellular Responses to Microenvironmental Cues as a Breast Cancer Susceptibility Factor The effects of chronic and acute toxicological exposures on the expression of the tumor suppressor p16INK4a p53 and NF-κB: different strategies for responding to stress lead to a functional antagonism P13. 2 The role of mitochondria in the regulation of gamma rays induced mTOR-dependent senescence Regulation of Forkhead BOX O tumor suppressors by Reactive Oxygen Species CSI-01–Cell Cycle & Checkpoints A novel approach towards finding regulatory microRNAs during phagosomal maturation in infection. The Impact of Physical Activity and Antioxidants on Tumor-Skeletal Muscle Crosstalk during Cancer: Deciphering Signaling Pathways Involved in Tumor Growth and … Par Proteins in Tumor Formation and Progression Identification and characterization of senescence-associated microRNAs in a mouse model of the XFE Progeroid Syndrome Immunoregulatory network and cancer-associated genes: molecular links and relevance to aging Ionizing radiation-mediated premature senescence and paracrine interactions with cancer cells enhance the expression of syndecan 1 in human breast … Telomere fragment induced amnion cell senescence: a contributor to parturition? Islet Biology/Insulin Secretion Telomere dysfunction: Role in arterial aging and hypertension Colorectal cancer-promoting activity of the senescent peritoneal mesothelium Senescent Carcinoma Associated Fibroblasts Up-regulate Interleukin 8 to Enhance Pancreatic Cancer Progression MOVD 2013 The Role of Prolactin in the Cellular Response to DNA Damaging Agents Studies on the Developmental Changes in Parvalbumins of the Catfish, Heteropneustes fossilis (Bloch) Forum on aging and skeletal health: summary of the proceedings of an ASBMR workshop Analysis of temporal gene expression during Bacillus subtilis spore germination and outgrowth Analysis of gene expression during aging of CGNs in culture: implication of SLIT2 and NPY in senescence HIF1α regulates Mitochondrial biogenesis and Cellular senescence induced by Gamma Radiation Roles of senescence escape and epigenetic modifications in liver cancer Autophagy and inflammation in the pathogenesis of idiopathic dilated cardiomyopathy Interventions for age-related diseases: shifting the Differential expression of cellular senescence markers in the assessment of breast cancer development Pleiotropic cellular functions of PARP1 in longevity and aging: genome maintenance meets inflammation The role of Inhibitor of DNA binding 4 (Id4) in mammary gland development and breast cancer The Role of Photodynamic Therapy in Wound Healing and Scarring in Human Skin Melatonin maintains mitochondrial membrane potential and attenuates activation of initiator (casp‐9) and effector caspases (casp‐3/casp‐7) and PARP in UVR … Pathogenesis of intervertebral disc degeneration Thymic involution perturbs negative selection and leads to chronic inflammation Elucidating Molecular Changes in CD8+ T cells During Aging High-throughput Screening of Age-related Changes in Caenorhabditis elegans Causes, consequences, and reversal of immune system aging Senescence and apoptosis: dueling or complementary cell fates? Frequency of the cancer-resistant phenotype in SR/CR mice and the effect of litter seriation Understanding the roles of Non-homologous end joining and p53 after DNA damage IGF-binding protein 2–oncogene or tumor suppressor? Regulatory Mechanisms of NK-Cell-Mediated Immune Surveillance of Senescent Cells Suppression of autophagy during liver regeneration impairs energy charge and hepatocyte senescence in mice Mechanisms of tissue injury in autoimmune liver diseases Telomere dysfunction and senescence in the ageing lung and age-related lung disease HDAC 1 inhibition by melatonin leads to suppression of lung adenocarcinoma cells via induction of oxidative stress and activation of apoptotic pathways Poster session 3 The senescent cell induced bystander effect The Function and Regulation of Senescent Stromal-Derived Osteopontin Effects of chemotherapy and radiotherapy in rectal cancer: significance of different cellular outcomes in tumor behavior Polycomb Repressive Complex 1 Coordinates Enhanced Replication and Transcription in Transit Amplifying Chondrogenic Progenitors. Molecular Tuning Of Telomerase Activity In Senescent Human T Cells Role of squamous cell carcinoma antigen (SCCA) in oncogenic Ras-mediated tumorigenesis Increased oxidative and nitrative stress accelerates aging of the retinal vasculature in the diabetic retina The role of calcification regulatory proteins in the arterial stiffening of chronic kidney disease stages 3 & 4 Age-like Phenotype of Microglia During HIV-1 Infection Characterisation of the molecular and functional changes The biology of aging: implications for diseases of aging and health care in the twenty-first century Cytokine and nitric oxide production in inflammatory arthritis Anti-Aging Effects of the Transcendental Meditation Program: Analysis of Ojas Level and Global Gene Expression Investigating the chondrogenic phenotype in clinically relevant cells: the effect of hTERT expression The diet-microbiota-metabolite axis regulates the host physiology Role of stromal fibroblasts in prostate carcinoma progression and metabolic reprogramming of cancer cells Regulation and inhibition of pro-tumorigenic microenvironments Metal-induced oxidative stress in human fibroblasts: A role in cellular ageing EVALUATING THE ROLE OF NF-êB SUPPRESSION IN AMELIORATING MAMMALIAN DISEASE: AN EXAMINATION OF INFLAMMATORY BOWEL DISEASE AND … Session held on 9 July 2016 MAD2 depletion triggers premature cellular senescence in human primary fibroblasts by activating a p53 pathway preventing aneuploid cells propagation Molecular mechanism underlying the tumor-promoting functions of carcinoma-associated fibroblasts Understanding the pathophysiology and challenges of development of medical countermeasures for radiation-induced vascular/endothelial cell injuries: report of a … Regulation and Inhibition of Pro-Tumorigenic Microenvironments Changes in DNA methylation patterns in mammals with senescence, ageing and energy restriction Methamphetamine accelerates cellular senescence and aging through CYP2D-dependent stimulation of ceramide biosynthesis Program Committee: Sabine Fleming Markus Boehm Knut Schaekel Martin Metz Thomas Tueting Muscle ageing and anabolic response in the context of healthy and chronically HIV infected individuals Pathway Profiling Of Replicative And Induced Senescence Role of Tumor Suppressor DMP1 in the Initiation and Progression of Breast Cancer Revista de Endogenous retroelements in cellular senescence and related pathogenic processes: promising drug targets in age-related diseases Interactions between mitochondria and inflammatory factors during cellular senescence Using drug treatments to control genome behaviour in normal and Hutchinson-Gilford Progeria Syndrome fibroblasts, with and without hTERT immortalisation The chronic lymphocytic leukemia clone disrupts the bone marrow microenvironment Understanding vascular diseases: lessons from premature aging syndromes Epigenetic mechanisms of longevity and aging The role of DNA damage and repair in aging through the prism of Koch-like criteria Nutritional roles of selenium in cellular and mouse aging Anisotropy in the anodic oxidation of silicon in KOH solution Tumor Microenvironment Investigating the role of DNA polymerase beta in the aging phenotype of Down syndrome Diamond Sponsor EXTRACELLULAR MATRIX PROTEINS AND EPITHELIAL CELL PLASTICITY IN PROGRESSION OF BREAST AND PROSTATE CANCER Noncoding RNA in age-related cardiovascular diseases Identification and characterisation of telomere regulatory and signalling pathways after induction of telomere dysfunction Activity and controlled delivery of epigallocatechin 3-gallate in the treatment of degenerative disc disease State-of-the-Art Lecture Whose place is it?: examining the socio-spatial geography of obesity in young adults for an Australian context. Tumor Promoting Aspects of Senescence in Cancer Progression Long noncoding RNA H19 mediates melatonin inhibition of premature senescence of c‐kit+ cardiac progenitor cells by promoting miR‐675 Higher-Order Unfolding of Peri/Centric Satellite Heterochromatin is an Early and Consistent Event in Cell Senescence: A Dissertation Poster session 2 Hallmarks of progeroid syndromes: Lessons from mice and reprogrammed cells Proinflammatory cytokines in breast cancer: mechanisms of action and potential targets for therapeutics Nitrous oxide analgesia for bone marrow aspiration and biopsy–A randomized, controlled and patient blinded study 15th International Biennial Congress of the METASTASIS RESEARCH SOCIETY PLATFORM PRESENTATIONS The Genetic Landscapes of Inflammation-Driven Gastrointestinal Tract Cancers The senescent microenvironment promotes the emergence of heterogeneous cancer stem-like cells Mutual Reinforcement Between Telomere Capping and Canonical Wnt Pathway Activity in the Intestinal Stem Cell Niche The role of nitrosative and metabolic stress in vascular cell senescence Expression of p16INK4a in peripheral blood T‐cells is a biomarker of human aging MMP-2, MMP-9 production was significantly elevated by fibroblast cells isolated from rheumatoid arthritis patient when co-cultured with monocyte (THP-1) with … Evaluating the physiological reserves of older patients with cancer: the value of potential biomarkers of aging? POSTER PRESENTATIONS-Sunday, December 7 Array-based transcriptional analysis of Clostridium sporogenes UC9000 during germination, cell outgrowth and vegetative life Pancreatic Dysfunction in Shwachman-Diamond Syndrome The wound healing, chronic fibrosis, and cancer progression triad Senescence suppressors: their practical importance in replicative lifespan extension in stem cells Contributions of Activated Hepatic Stellate Cells to Hepatocarcinogenesis Principles of Medical Management of Ulcerative Colitis Proceedings of the 26th annual meeting Chiba, Japan, October 18–20, 1984 Roles of the ING1 Epigenetic Regulator in Breast Cancer Directions in Post-Traumatic Arthritis Metabolic regulation of intestinal stem cell function in Drosophila melanogaster Senescent endothelial cells: Potential modulators of immunosenescence and ageing Genotype distribution-based inference of collective effects in genome-wide association studies: insights to age-related macular degeneration disease … Sustained low-dose treatment with the histone deacetylase inhibitor LBH589 induces terminal differentiation of osteosarcoma cells The multiple roles of A-type lamins in cellular aging, cell cycle progression and the DNA damage response. Loss of the osteogenic differentiation potential during senescence is limited to bone progenitor cells and is dependent on p53 Podocyte Injury Causes Chronic Kidney Disease in the Ercc1 Deficient Mouse Model of Accelerated Aging Biological ageing, inflammation and nutrition: how might they impact on systemic sclerosis? Detection of mesenchymal stem cells senescence by prelamin A accumulation at the nuclear level The role of chondrocyte senescence in osteoarthritis A senescent cell bystander effect: Senescence‐induced senescence Changes in regenerative capacity through lifespan Cancer, Senescence, and Aging: Translation from Basic Research to Clinics Accumulation of spontaneous γH2AX foci in long-term cultured mesenchymal stromal cells Extracellular matrix and liver disease Programmed cell senescence during mammalian embryonic development Role of MicroRNA-146a in Vascular Inflammation and Atherosclerosis The effect of radiation on cellular ageing Programmed cell death in aging Update on the mechanisms of action of anti‑TNF‑α antibodies and their clinical implications in inflammatory bowel disease Clinical Investigation Program RCS-MED-300 (R1) Analysis of Temporal Gene Expression Postnatal Hdac3 deficiency in chondrocytes alters cortical bone architecture and increases articular cartilage thickness with age EMT and oxidative stress: a bidirectional interplay affecting tumor malignancy Regulation of 11β-Hydroxysteroid Dehydrogenase Type 1 and 2 in Rheumatoid Arthritis Impacts of Aging and Inflammation on Mycobacterium tuberculosis Control A review of melatonin as a suitable antioxidant against myocardial ischemia–reperfusion injury and clinical heart diseases Long noncoding RNAs (lncRNAs) and the molecular hallmarks of aging Integrative analysis of longevity, age-related diseases and aging-associated processes: Construction of the NetAge database SNEVPrp19/PSO4 deficiency increases PUVA‐induced senescence in mouse skin miR‐17, miR‐19b, miR‐20a, and miR‐106a are down‐regulated in human aging Pašatjaunošanās un paātrinātas novecošanās attiecības normālās un vēža šūnās pēc DNS bojājuma Circulating microRNAs as novel biomarkers for bone diseases–Complex signatures for multifactorial diseases? Aldehyde dehydrogenase activity of breast cancer stem cells is primarily due to isoform ALDH1A3 and its expression is predictive of metastasis Time-and Concentration-dependent response of a liver cell line to Benzo (a) pyrene Practical alternatives to chronic caloric restriction for optimizing vascular function with ageing Manipulation du métabolisme énergétique dans les leucémies aiguës myéloïdes: mitochondrie, apoptose et mécanisme d’action de la metformine Insulin-like growth factor binding protein-6 delays replicative senescence of human fibroblasts Intervention in Genotoxic Stress–Induced Senescence by Cordycepin Through Activation of eIF2α and Suppression of Sp1 p62: linking protein homeostasis and the DNA damage response during ageing Molecular basis of Osteoarthritis and aspects of cellular senescence in disease Etude du facteur de réparation de l’ADN, Xeroderma pigmentosum du groupe C (XPC), dans les cellules souches hématopoïétiques HIV-1 Infection, Antiretroviral Therapies, and HIV-Associated Atherosclerosis The role of the transcriptional regulation of stromal cells in chronic inflammation Cell ageing: a flourishing field for neurodegenerative diseases Senescence of bone marrow mesenchymal stromal cells is accompanied by activation of p53/p21 pathway in myelodysplastic syndromes Rat retinal transcriptome: effects of aging and AMD-like retinopathy Aging of the liver: what this means for patients with HIV Pharmacology and biochemistry of salicylates and related drugs A report to inform the development of a clinical practice guideline for rehabilitation post total knee arthroplasty in a South African public hospital Nutrigerontology: why we need a new scientific discipline to develop diets and guidelines to reduce the risk of aging‐related diseases Cellular responses to zinc involving the transcription factor ZNF658 and its target genes Determining the role of scavenger receptor class B type I as a source of cholesterol for de novo androgen synthesis in castration-resistant prostate cancer Antioxidant properties of mesalamine in colitis inhibit phosphoinositide 3-kinase signaling in progenitor cells Aging and the Host Response to Implanted Biomaterials A role for epigenetics in aging and the age-dependent response to ionizing radiation Interleukin 6 signaling regulates promyelocytic leukemia protein gene expression in human normal and cancer cells Mechanisms of microRNAs in atherosclerosis Mechanisms of Ageing and Development Telomeres and telomerase: their mechanisms of action and the effects of altering their functions Lifespan‐extending caloric restriction or m TOR inhibition impair adaptive immunity of old mice by distinct mechanisms Fourth International Ankle Symposium, July 16–18, 2009, Sydney, Australia Telomeres, Aging, and Nutrition Perspectives in pain research 2014: neuroinflammation and glial cell activation: the cause of transition from acute to chronic pain? On the Role of Prelamin A in the Heart Therapeutic effects and the underlying mechanisms of qing-dai powder against experimental colitis in mice Role of Gut Microbiome in the Modulation of Environmental Toxicants and Therapeutic Agents 43nd Annual Meeting of the Arbeitsgemeinschaft Dermatologische Forschung eV (ADF) furanosidase f Stellate cells Pressure and cold pain threshold reference values in a large, young adult, pain-free population The ENRGISE Pilot Study Protocol A Comparative Analysis of Stress Granule Assembly in Replicative and Stress-Induced Premature Senescence Mutant lamin A links prophase to a p53 independent senescence program Identification and characterization of downstream effector protein (s) regulated by p53 and pRb Long-term efficacy of spironolactone on pain, mood, and quality of life in women with fibromyalgia: An observational case series Telomere shortening and immune activity in war veterans with posttraumatic stress disorder KAROLINSKA INSTITUTET, STOCKHOLM, SWEDEN Interplay between the myc oncoprotein, cyclin-dependent kinases and e3 ubiquitin ligases Calcitonin gene-related peptide (CGRP) in age-associated vascular inflammation and leukocyte trafficking The Contribution of DNA Interstrand Crosslinks to Aging ART. IV.–A Statistical Contribution to our knowledge of Abscess, and other Diseases Consequent upon the Lodgment of Foreign Bodies in the Appendix Vermiformis … Molecular Mechanisms of Cancer Progression: The Central Role of the Retinoblastoma Family Members Determination of Autoantibody IgG Subclass and Partial Sequence using Multi-affinity Purification with Multi-enzymatic Digestion by LC-MS Investigating the role of mitochondrial respiratory chain activity and mitochondrial DNA damage in skin ageing Prevalence of lumbo-pelvic pain and factors associated with it in cyclists in Johannesburg Health Ballistics: Multiple Reference Point Informed Probability Theory Translational Science 2014 Meeting Abstracts Proteomic profiling following cryopreservation Functional interaction between FOXO4 and p53 in response to oncogenic BRAF signaling Translational Science 2014 Meeting Abstracts Mechanism of Tumorigenesis by Cancer-Associated Mutations of INI1/SMARCB1, a Component of the SWI/SNF Chromatin Remodeling Complex Ecology of juvenile salmon in shallow tidal freshwater habitats in the vicinity of the Sandy River delta, lower Columbia River, 2008 The role of bone morphogenetic protein 4 in the pathogenesis of choroidal neovascularization in age-related macular degeneration The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesisSarcopenic obesity or obese sarcopenia: a cross talk between age-associated adipose tissue and skeletal muscle inflammation as a main mechanism of the …Cellular Senescence Biomarker p16INK4a+ Cell Burden in Thigh Adipose is Associated With Poor Physical Function in Older Women Expansion of adipose tissue ‐derived stromal cells at “physiologic” hypoxia attenuates replicative senescenceAge-induced changes in white, brite, and brown adipose depots: a mini-review adipose tissue Rare progerin-expressing preadipocytes and adipocytes contribute to tissue depletion over time Cellular aging contributes to failure of cold-induced beige adipocyte formation in old mice and humans Healthy ageing in 2016: Obesity in geroscience—is cellular senescence the culprit? Micro-RNAS regulate metabolic syndrome-induced senescence in porcine adipose tissue -derived mesenchymal stem cells through the P16/MAPK pathwayTherapeutic doses of doxorubicin induce premature senescence of human mesenchymal stem cells derived from menstrual blood, bone marrow and adipose tissue Growth hormone’s effect on adipose tissue : quality versus quantityAging, cell senescence, and chronic disease: emerging therapeutic strategies Neovascular deterioration, impaired NADPH oxidase and inflammatory cytokine expression in adipose-derived multipotent cells from subjects with metabolic … Dietary restriction ameliorates age-related increase in DNA damage, senescence and inflammation in mouse adipose tissue yFisetin is a senotherapeutic that extends health and lifespan adipose tissue Fat depot-specific differences of macrophage infiltration and cellular senescence in obese bovine adipose tissue sSource of chronic inflammation in aging Aging impairs beige adipocyte differentiation of mesenchymal stem cells via the reduced expression of Sirtuin 1 Maternal high calorie diet induces mitochondrial dysfunction and senescence phenotype in subcutaneous fat of newborn mice Reduction of premature aging markers after gastric bypass surgery in morbidly obese patients Age-and tissue-specific expression of senescence biomarkers in mice Senolytics improve physical function and increase lifespan in old age Silencing of the small GTPase DIRAS3 induces cellular senescence in human white adipose stromal/progenitor cells ANGPTL2―A New Causal Player in Accelerating Heart Disease Development in the Aging― Melatonin prevents senescence of canine adipose-derived mesenchymal stem cells through activating NRF2 and inhibiting ER stress Cellular senescence: a translational perspective Rejuvenating senolytics Regulation of lipogenesis in human adipose tissue : Effect of metabolic stress, dietary intervention and aging.Cellular senescence in osteoarthritis pathology Metabolic memory of dietary restriction ameliorates DNA damage and adipocyte size in mouse visceral adipose tissue Aging of Brown and Beige/Brite adipose tissue Impact of senescence‐associated secretory phenotype and its potential as a therapeutic target for senescence‐associated diseases Cellular Senescence: At the Nexus of Mechanisms of Age-and Obesity-Related Metabolic Dysfunction The Progressive Low Chronic Inflammation On Oral Tissues In Elderly High Circulating Levels of ANGPTL2: Beyond a Clinical Marker of Systemic Inflammation Basic research: killing the old: cell senescence in atherosclerosis Cellular senescence: implications for metabolic disease Melatonin regulates PARP 1 to control the senescence‐associated secretory phenotype (SASP ) in human fetal lung fibroblast cellsExamination of the Inhibitory Protein P21 in Omento Fat as an Indication of Adipocyte Proliferation Augmentation of Dermal Wound Healing by adipose tissue -Derived Stromal Cells (ASC)Cell-free therapy with the secretome of adipose tissue -derived stem cells in rats’ frozen-thawed ovarian graftsThe Complexity of adipose tissue Targeting cellular senescence prevents age-related bone loss in mice Targeting our aging cells to treat metabolic disease Different response to hypoxia of adipose-derived multipotent cells from obese subjects with and without metabolic syndrome Mitochondria in cell senescence: is mitophagy the weakest link? Diabetes and Adipocyte Dysfunction Nonalcoholic fatty liver disease promotes hepatocellular carcinoma through direct and indirect effects on hepatocytes Short-term sustained hyperglycaemia fosters an archetypal senescence-associated secretory phenotype in endothelial cells and macrophages Senescence and aging: Causes, consequences, and therapeutic avenues A summary of the Proceedings of the Thirteenth International Symposium on the Neurobiology and Neuroendocrinology of Aging, Bregenz, Austria July 17–22, 2016 Killing the old: cell senescence in atherosclerosis New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463 Parallels Between Skeletal Muscle and Bone Aging Aging, obesity, and inflammatory age-related diseases Molecular pathology endpoints useful for aging studies Cellular senescence in postmitotic cells: beyond growth arrest Senescent cells: an emerging target for diseases of ageing Prevention of senescence in vasculature through quiescence Resveratrol reduces senescence-associated secretory phenotype by SIRT1/NF-κB pathway in gut of the annual fish Nothobranchius guentheri Inflammageing and metaflammation: the yin and yang of type 2 diabetes Chronic inflammation and sarcopenia: A regenerative cell therapy perspective Ageing: from inflammation to cancer Senotherapy: growing old and staying young? Down-regulation of guanylate binding protein 1 causes mitochondrial dysfunction and cellular senescence in macrophages Cellular senescence: Molecular mechanisms and pathogenicity Anti-inflammatory effect of Chang-An-Shuan on TNBS-induced experimental colitis in rats Senescent B cells in aging and age-related diseases: their role in the regulation of antibody responses The fountain of youth by targeting senescent cells? HIV-associated cellular senescence: a contributor to accelerated aging Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty Activated tissue-resident mesenchymal stromal cells regulate natural killer cell immune and tissue-regenerative function Immunosenescence induced by plasma from individuals with obesity caused cell signaling dysfunction and inflammation Circadian Disruption, Sleep Loss, and Low-Grade Inflammation Histone MacroH2A1: a chromatin point of intersection between fasting, senescence and cellular regeneration PPARα regulates tumor cell proliferation and senescence via a novel target gene carnitine palmitoyltransferase 1C p16 (Ink4a) and senescence-associated β-galactosidase can be induced in macrophages as part of a reversible response to physiological stimuli Novel Role of Blackberries in Senescence and Atherosclerosis in ApoE-/-Mice The Role of Na/K-ATPase Signaling in Oxidative Stress Related to Aging: Implications in Obesity and Cardiovascular Disease Cellular senescence in renal ageing and disease Quantitative analysis of cellular senescence in culture and in vivo Ketone bodies mimic the life span extending properties of caloric restriction Rapamycin inhibits the secretory phenotype of senescent cells by a Nrf2‐independent mechanism Gut microbiota and mTOR signaling: insight on a new pathophysiological interaction Gut microbiota, fatty liver disease, and hepatocellular carcinoma Increase in tumor suppressor Arf compensates gene dysregulation in in vitro aged adipocytes Inhibiting cellular senescence: a new therapeutic paradigm for age-related osteoporosis The Na/K-ATPase oxidant amplification loop regulates aging Role of lncRNAs in aging and age‐related diseases TNFα-senescence initiates a STAT-dependent positive feedback loop, leading to a sustained interferon signature, DNA damage, and cytokine secretion Gut microbiota-mediated inflammation in obesity: a link with gastrointestinal cancer The impact of senescence-associated T cells on immunosenescence and age-related disorders Study on the therapeutic effects of salicylazosulfapyridine on ulcerative colitis in rats Emerging metabolic risk factors in hepatocellular carcinoma and their influence on the liver microenvironment Low-grade inflammation in the relationship between sleep disruption, dysfunctional adiposity, and cognitive decline in aging Musculoskeletal senescence: a moving target ready to be eliminated Inflammatory response in the CNS: friend or foe? Inflammation-accelerated senescence and the cardiovascular system: mechanisms and perspectives Biphasic modeling of mitochondrial metabolism dysregulation during aging Myeloid-derived suppressor cells (MDSC): an important partner in cellular/tissue senescence Mitochondrial peptides modulate mitochondrial function during cellular senescence Senescence of mesenchymal stem cells Sirtuins, a promising target in slowing down the ageing process Endothelin receptor type b blocker attenuates severity of osteoarthritis by clearance of senescent cells The Rbm38-p63 feedback loop is critical for tumor suppression and longevity Identification of senescent cell surface targetable protein DPP4 Caloric Restriction, Sirtuins, and Ageing 5-methoxytryptophan protects MSCs from stress induced premature senescence by upregulating FoxO3a and mTOR SCAMP4 enhances the senescent cell secretome Age-related changes in glucose metabolism, hyperglycemia, and cardiovascular risk Investigating the Role of NRIP1 in Skin Aging: Depletion of NRIP1 Delays Senescence, Reduces Inflammation and Enhances Autophagy in Adipocytes The role of cellular senescence in aging through the prism of Koch-like criteria Heat-induced extracellular HSP72 release is blunted in elderly diabetic people compared with healthy middle-aged and older adults, but it is partially restored by … Drosophila as a Model to Study the Link between Metabolism and Cancer Oxidative stress-mediated senescence in mesenchymal progenitor cells causes the loss of their fibro/adipogenic potential and abrogates myoblast fusion Immune Senescence and Inflammaging in Neurological Diseases Inflammaging and human longevity in the omics era Role of sphingolipids in senescence: implication in aging and age-related diseases Mitochondrial activity and dynamics changes regarding metabolism in ageing and obesity Premature physiologic aging as a paradigm for understanding increased risk of adverse health across the lifespan of survivors of childhood cancer The molecular intersection between senescence and major depression in the elderly Senescent cells: a new Achilles’ heel to exploit for cancer medicine? From cellular senescence to age-associated diseases: miRNAs as tools and targets for healthy ageing Attenuation of inflammation and cartilage degradation by sulfasalazine-containing hyaluronic acid on osteoarthritis rat model Ripk3 regulates cardiac microvascular reperfusion injury: the role of IP3R-dependent calcium overload, XO-mediated oxidative stress and F-action/filopodia-based … The dual role of cellular senescence in developing tumors and their response to cancer therapy Identification of new genes associated to senescent and tumorigenic phenotypes in mesenchymal stem cells Obesity and type-2 diabetes as inducers of premature cellular senescence and ageing Cellular senescence in osteoarthritis and anti-aging strategies Downregulation of miR-130b~ 301b cluster is mediated by aberrant promoter methylation and impairs cellular senescence in prostate cancer Hydrogen sulfide ameliorates aging-associated changes in the kidney The peritoneal “soil” for a cancerous “seed”: a comprehensive review of the pathogenesis of intraperitoneal cancer metastases Aging mechanisms and intervention targets Inflammaging and ‘Garb-aging’ NLRP3 inflammasome activation in inflammaging Mechanisms and functions of cellular senescence The Effects of the Senescent Preadipocyte Secretome on Skeletal Muscle Cells Ras signaling in aging and metabolic regulation Cellular senescence in brain aging and neurodegenerative diseases: evidence and perspectives Anthracycline cardiotoxicity: looking for new therapeutic approaches targeting cell senescence? Coenzyme Q10 prevents senescence and dysfunction caused by oxidative stress in vascular endothelial cells Endothelial cell senescence with aging in healthy humans: prevention by habitual exercise and relation to vascular endothelial function Senescent cells and osteoarthritis: a painful connection Oncogenic KRAS and the Inflammatory Micro-Environment in Pancreatic Cancer Linking cellular stress responses to systemic homeostasis Cellular senescence, senescence-associated secretory phenotype, and chronic kidney disease With great age comes great metastatic ability: ovarian cancer and the appeal of the aging peritoneal microenvironment Lipometabolism and Glycometabolism in Liver Diseases A null mutation in SERPINE1 protects against biological aging in humans CELLULAR STRESS RESPONSE GENES IN ALZHEIMER’S DISEASE: INSIGHTS FROM GENOME-WIDE ASSOCIATION STUDIES Osteoarthritis Biology Fibroblast senescence in the pathology of idiopathic pulmonary fibrosis Oxidative stress in mesenchymal stem cell senescence: regulation by coding and noncoding RNAs Divergent mechanisms of metabolic dysfunction drive fibroblast and T-cell senescence Is the secret for a successful aging to keep track of cancer pathways? Acute genotoxic stress-induced senescence in human mesenchymal cells drives a unique composition of senescence messaging secretome (SMS) HIF1α deletion facilitates adipose stem cells to repair renal fibrosis in diabetic mice Deletion of Nrip1 Extends Female Mice Longevity, Increases Autophagy, and Delays Cell Senescence Calcium signaling and cellular senescence Stress, cell senescence and organismal ageing Senescence as a novel mechanism involved in β-adrenergic receptor mediated cardiac hypertrophy Activation of sirtuin 1 by catalpol-induced down-regulation of microRNA-132 attenuates endoplasmic reticulum stress in colitis Secondary Unconjugated Bile Acids Induce Hepatic Stellate Cell Activation MicroRNA regulation of oxidative stress-induced cellular senescence Yields and chondrogenic potential of primary synovial mesenchymal stem cells are comparable between rheumatoid arthritis and osteoarthritis patients The spectrum of fundamental basic science discoveries contributing to organismal aging Seasonal variation in vitamin D in association with age, inflammatory cytokines, anthropometric parameters, and lifestyle factors in older adults The imbalance between n-6/n-3 polyunsaturated fatty acids and inflammatory bowel disease: a comprehensive review and future therapeutic perspectives Aging, inflammation and the environment Rejuvenation of aged hematopoietic stem cells Pathogenesis of wound healing disorders in the elderly Microvesicles as potential biomarkers for the identification of senescence in human mesenchymal stem cells Aging and the immune system: An overview The light and shadow of senescence and inflammation in cardiovascular pathology and regenerative medicine BBA-Molecular Basis of Disease The impact of the Standard American Diet in rats: Effects on behavior, physiology and recovery from inflammatory injury The macroH2A1. 1–PARP1 axis at the intersection between stress response and metabolism Integrative Cardiovascular Physiology and Pathophysiology: Endothelial cell senescence with aging in healthy humans: prevention by habitual exercise and … Circulating markers of ageing and allostatic load: A slow train coming Health relevance of the modification of low grade inflammation in ageing (inflammageing) and the role of nutrition The Role of p16-Positive Senescent Cells in an Age-Related Disease and Aging Itself Regulation of normal and leukemic stem cells through cytokine signaling and the microenvironment Autophagy and the cell biology of age-related disease Using comparative biology to understand how aging affects mitochondrial metabolism Maternal obesity impairs skeletal development in adult offspring Cellular senescence links aging and diabetes in cardiovascular disease Apelin/APJ system: A novel promising target for anti-aging intervention The gut–liver axis and the intersection with the microbiome Targeting senescent cells in fibrosis: pathology, paradox, and practical considerations A new mouse model of frailty: the Cu/Zn superoxide dismutase knockout mouse Mesenchymal stem cells secretory responses: senescence messaging secretome and immunomodulation perspective Cell cycle and apoptosis regulator 2 at the interface between DNA damage response and cell physiology Mechanisms of normal tissue injury from irradiation Immunological aspects of age-related diseases Happily (n) ever after: aging in the context of oxidative stress, proteostasis loss and cellular senescence Senescence in hepatic stellate cells as a mechanism of liver fibrosis reversal: a putative synergy between retinoic acid and PPAR-gamma signalings Senescence in health and disease Linking a role of lncRNAs (long non-coding RNAs) with insulin resistance, accelerated senescence, and inflammation in patients with type 2 diabetes Emerging players at the intersection of chondrocyte loss of maturational arrest, oxidative stress, senescence and low-grade inflammation in osteoarthritis Mandibuloacral dysplasia: A premature ageing disease with aspects of physiological ageing Immunologic Nutrient sensing pathways as therapeutic targets for healthy ageing Articular cartilage aging-potential regenerative capacities of cell manipulation and stem cell therapy Fibroblast activation and senescence in oral cancer MicroRNAs and the metabolic hallmarks of aging Genomic profiling and metabolic homeostasis in primary liver cancers Mitochondria, oxidative stress and innate immunity Human menstrual blood: a renewable and sustainable source of stem cells for regenerative medicine Balancing between aging and cancer: molecular genetics meets traditional Chinese medicine The mechanism of alopolysaccharide protecting ulceralive colitis Glutathione peroxidase 3 delivered by hiPSC-MSCs ameliorated hepatic IR injury via inhibition of hepatic senescence Novel strategies for anti-aging drug discovery Cellular and molecular mechanisms of asthma and COPD The role of kinase modulators in cellular senescence for use in cancer treatment Inflammaging Sex-specific differences in hypertension and associated cardiovascular disease Comparison of several commonly used detection indicators of cell senescence Loss of SATB1 Induces a p21 Dependent Cellular Senescence Phenotype in Dopaminergic Neurons Effects of bioactive compounds on senescence and components of senescence associated secretory phenotypes in vitro The integration of inflammaging in age-related diseases Sphingolipids at the Crossroads of NAFLD and Senescence Mitochondria, telomeres and cell senescence: implications for lung ageing and disease SASP SASP Mechanisms of dysfunction in the aging vasculature and role in age-related disease Knockdown of IL-8 Provoked Premature Senescence of Placenta-Derived Mesenchymal Stem Cells Treating Age-Related Diseases with Somatic Stem Cells Controlling insulin resistance through modulation of interplay between mediators of cellular senescence: A mathematical study Mechanisms of renal fibrosis Nitric oxide-heat shock protein axis in menopausal hot flushes: neglected metabolic issues of chronic inflammatory diseases associated with deranged heat shock … Characterization of brusatol self-microemulsifying drug delivery system and its therapeutic effect against dextran sodium sulfate-induced ulcerative colitis in mice Innate immunity and cellular senescence: The good and the bad in the developmental and aged brain Stellate cells in tissue repair, inflammation, and cancer YAP inhibits the apoptosis and migration of human rectal cancer cells via suppression of JNK-Drp1-mitochondrial fission-HtrA2/Omi pathways DHA-enriched fish oil upregulates cyclin-dependent kinase inhibitor 2A (P16INK) expression and downregulates telomerase activity without modulating effects of … Antioxidant and anti-senescence effect of metformin on mouse olfactory ensheathing cells (mOECs) may be associated with increased brain-derived neurotrophic … Senescent intervertebral disc cells exhibit perturbed matrix homeostasis phenotype Procancerogenic activity of senescent cells: A case of the peritoneal mesothelium Key proteins and pathways that regulate lifespan miRNAs in stem cell aging and age-related disease Unhealthy Stem Cells: When Health Conditions Upset Stem Cell Properties Cellular senescence and inflammaging in age-related diseases Rapamycin increases oxidative metabolism and enhances metabolic flexibility in human cardiac fibroblasts Isolation and prolonged expansion of oral mesenchymal stem cells under clinical-grade, GMP-compliant conditions differentially affects “stemness” properties Extracellular vesicles in the tumor microenvironment: therapeutic resistance, clinical biomarkers, and targeting strategies Down-regulation of hepatic MBOAT7 by hyperinsulinemia favors steatosis development The Impact of the Mediterranean Diet on Aging, Frailty, and Longevity The epigenetics of inflammaging: The contribution of age-related heterochromatin loss and locus-specific remodelling and the modulation by environmental … Program & Book of Abstracts: IUBMB Advanced School Nutrition, Metabolism and Aging 2018 Immune senescence: significance of the stromal microenvironment Extracellular vesicles and aging Senescence and cell death in chronic liver injury: roles and mechanisms underlying hepatocarcinogenesis Energy to Fight Infection Senescent, dysfunctional human cardiac progenitor cells (CPCs) accumulate in the aged heart and elimination of senescent cells enhances CPC activation and … Cellular senescence, geroscience, cancer and beyond Stem Cell Applications in Rejuvenation Progeria and accelerated cardiovascular aging Camellia Oil (Camellia oleifera Abel.) Modifies the Composition of Gut Microbiota and Alleviates Acetic Acid-Induced Colitis in Rats Ionizing radiation-induced cellular senescence promotes tissue fibrosis after radiotherapy. A review Major trauma and acceleration of the ageing process Inflammatory bowel diseases: Current therapeutic approaches and potential of using stem cells PINK1-PARK2-mediated mitophagy in COPD and IPF pathogeneses Obesity, Metabolism, and Aging: A Multiscalar Approach PPARγ-activation increases intestinal M1 macrophages and mitigates formation of serrated adenomas in mutant KRAS mice Current Approaches of Anti-inflammatory-Dependent Antiaging Strategies Immunosenescence in neurocritical care Age-dependent increase in angiopoietin-like protein 2 accelerates skeletal muscle loss in mice Cellular senescence: a view throughout organismal life Effect of Mst1 on endometriosis apoptosis and migration: role of Drp1-related mitochondrial fission and parkin-required mitophagy Ceramide synthase 4: a novel metabolic regulator of oncogene-induced senescence Regulation and function of p53: A perspective from Drosophila studies Relevance of the p53–MDM2 axis to aging Administration of hydrogen-rich water prevents vascular aging of the aorta in LDL receptor-deficient mice Exercise and bone health across the lifespan Urothelial senescence in the pathophysiology of diabetic bladder dysfunction-a novel hypothesis Gut microbiota’s relationship with liver disease and role in hepatoprotection by dietary natural products and probiotics Developmental programming of aging trajectory Senescent microvesicles: a novel advance in molecular mechanisms of atherosclerotic calcification Long noncoding RNA Bmncr regulates mesenchymal stem cell fate during skeletal aging Disruptions in gut microbial-host co-metabolism and the development of metabolic disorders In vivo effects of DNA lesions in Nucleotide Excision Repair deficient mice Bone Research Society, Annual Meeting 2017 Proceedings The clinical potential of senolytic drugs Anti-senescence compounds: a potential nutraceutical approach to healthy aging Loss of ovarian hormones and accelerated somatic and mental aging Inflammation and premature aging in advanced chronic kidney disease C. elegans eats its own intestine to make yolk leading to multiple senescent pathologies Aging With HIV and Oxidative Stress Risk factors and prevention of hepatocellular carcinoma in the era of precision medicine DICER1: a key player in rheumatoid arthritis, at the crossroads of cellular stress, innate immunity, and chronic inflammation in aging miR-125a induces apoptosis, metabolism disorder and migrationimpairment in pancreatic cancer cells by targeting Mfn2-related mitochondrial fission Biology of Aging Cellular senescence in tissue repair: every cloud has a silver lining Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis Automated image analysis detects aging in clinical-grade mesenchymal stromal cell cultures Cellular senescence, neurological function, and redox state Mesenchymal stem cell therapy protects lungs from radiation-induced endothelial cell loss by restoring superoxide dismutase 1 expression Mechanisms of vascular aging Environmental and Physiological Cues on the Hypothalamus During Aging Reaction time in healthy elderly is associated with chronic low-grade inflammation and advanced glycation end product Phospholipase C delta 4 (PLCδ4) is a nuclear protein involved in cell proliferation and senescence in mesenchymal stromal stem cells Epigenetics in cardiac fibrosis: emphasis on inflammation and fibroblast activation Hematopoietic insults damage bone marrow niche by activating p53 in vascular endothelial cells PGC-1α protects RPE cells of the aging retina against oxidative stress-induced degeneration through the regulation of senescence and mitochondrial quality control … Pro-resolving lipid mediators: Agents of anti-ageing? Hyperglycaemia Stress-Induced Renal Injury is Caused by Extensive Mitochondrial Fragmentation, Attenuated MKP1 Signalling, and Activated JNK-CaMKII-Fis1 … Energy restriction in renal protection Targeting cancer stem cells and their niche: Perspectives for future therapeutic targets and strategies Senescence-associated microRNAs Cellular senescence and liver disease: Mechanisms and therapeutic strategies Gene expression hallmarks of cellular ageing Facing up to the global challenges of ageing Melatonin and inflammation—Story of a double‐edged blade The role of myeloid-derived suppressor cells (MDSC) in the inflammaging process Genomic deletion of GIT2 induces a premature age-related thymic dysfunction and systemic immune system disruption In vivo and in vitro study on the efficacy of terpinen-4-ol in dextran sulfate sodium-induced mice experimental colitis The emerging roles of microRNAs in stem cell aging Bone marrow-derived mesenchymal stromal cells promote colorectal cancer cell death under low-dose irradiation Umbilical cord–derived mesenchymal stromal cell–conditioned medium exerts in vitro antiaging effects in human fibroblasts Tetraploidy in cancer and its possible link to aging Senescent cells: a therapeutic target for cardiovascular disease Non-Cell autonomous effects of the senescence-associated secretory phenotype in cancer therapy The effect of green tea extract compounds on regulation of glucose homoeostasis in insulin-sensitive and breast cancer cells Mammalian STE20-Like Kinase 1 Deletion Alleviates Renal Ischaemia-Reperfusion Injury via Modulating Mitophagy and the AMPK-YAP Signalling Pathway Immunosenescence: the role of aging in the predisposition to neuro-infectious complications arising from the treatment of multiple sclerosis SIPS as a model to study age-related changes in proteolysis and aggregate formation Epithelial cell cycle behaviour in the injured kidney Immunosenescence and Ageing in HIV Long-term persistent organic pollutants exposure induced telomere dysfunction and senescence-associated secretary phenotype Aging, Telomere Integrity, and Antioxidant Food Advances in tendon mechanobiology DICER1: a key player in rheumatoid arthritis, at the crossroads of cellular stress, innate immunity and chronic inflammation in ageing G Protein-Coupled Receptor Systems as Crucial Regulators of DNA Damage Response Processes NR4A1 contributes to high-fat associated endothelial dysfunction by promoting CaMKII-Parkin-mitophagy pathways Age, gender and UV-exposition related effects on gene expression in in vivo aged short term cultivated human dermal fibroblasts Role Of COX2 In Cellular Senescence Tissue aging: the integration of collective and variant responses of cells to entropic forces over time Counterregulatory Effects of Ptx3 on Inflammation and Cellular Aging Resveratrol as an Activator or Inhibitor of Enzymes and Proteins Induction of a senescence-like phenotype in cultured human fetal microglia during HIV-1 infection Vitamin C, aging and Alzheimer’s disease Screening and treating prostate cancer in the older patient: decision making across the clinical spectrum Mechanisms driving the ageing heart Autophagy deficient keratinocytes display increased DNA damage, senescence and aberrant lipid composition after oxidative stress in vitro and in vivo Biomedical Research in Aging Modelling of mitochondrial metabolism in breast cancer Age and age-related diseases: role of inflammation triggers and cytokines Inducers of senescence, toxic compounds, and Senolytics: the multiple faces of Nrf2-activating phytochemicals in Cancer adjuvant therapy Epidermal Growth Factor Therapy Impact on Scar Tissue Resilience of Diabetic Lower Limbs Ulcers-An Enlightening Hypothesis The Impact of Membrane Phospholipid Composition and Extracellular Vesicles on the Immunoregulative Properties of Human Mesenchymal Stromal Cells Autophagy regulation in preeclampsia: Pros and cons The interplay between immunity and aging in Drosophila Reversing the immune ageing clock: lifestyle modifications and pharmacological interventions Nitric Oxide Regulates H2O2-Induced Senescence via S-Nitrosylation of NF-κB in Endothelial Cells Biliary bile acids in hepatobiliary injury–What is the link? Cover ImageReport and Abstracts of the 14th Meeting of IIM, the Interuniversity Institute of Myology,-Assisi (Italy), October 12-15, 2017 Role of the inflammation-autophagy- Novel treatment strategies for chronic kidney disease: insights from the animal kingdom Aging hallmarks: the benefits of physical exercise mTORC inhibitors as broad-spectrum therapeutics for age-related diseases Bioactive nutrients and nutrigenomics in age-related diseases The nematode Caenorhabditis elegans as a model for aging research Sleep health: reciprocal regulation of sleep and innate immunity Osteoblast suppression in multiple myeloma bone disease Yap regulates gastric cancer survival and migration via SIRT1/Mfn2/mitophagy Hypoxia Prevents Mitochondrial Dysfunction and Senescence in Human Cardiac Progenitor Cells Senolytika-současný stav In vivo and in vitro study of pancreatic islets aging: impact of endothelial senescence and microparticles on islet function Mechanisms of Obesity-related Hepatocarcinogensis Identification of rare and common genetic variants associated with hepatocellular carcinoma in patients with nonalcoholic fatty liver disease: mechanisms and clinical … Nutrient supply affects the mRNA expression profile of the porcine skeletal muscle Application of kinase inhibitors for anti-aging intervention Telomeres, aging and exercise: guilty by association? Long noncoding RNAs and RNA-binding proteins in oxidative stress, cellular senescence, and age-related diseases Effects of exercise on inflammatory, oxidative, and neurotrophic biomarkers on cognitively impaired individuals diagnosed with dementia or mild cognitive impairment … DNA damage-induced inflammation and nuclear architecture Hormonal modulation of ageing skin microstructure and mechanical properties The protective effects of Poria cocos-derived polysaccharide CMP33 against IBD in mice and its molecular mechanism Prospects of Pharmacological Interventions to Organismal Aging Induction, regulation and roles of neural adhesion molecule L1CAM in cellular senescence Investigating senescence in cellular plasticity and tissue regeneration DNA damage and senescence in osteoprogenitors expressing Osx1 may cause their decrease with age Targeting mitochondria to counteract age-related cellular dysfunction Attenuated Macrophage Infiltration in Glomeruli of Aged Mice Resulting in Ameliorated Kidney Injury in Nephrotoxic Serum Nephritis Mechanisms of Action of Drugs for Treating Endothelial Dysfunction in Diabetes Mellitus Nutrient supply affects the mRNA expression profile of the porcine skeletal muscle Oncogenic roles of the PI3K/AKT/mTOR axis Organ reserve, excess metabolic capacity, and aging Studies of Novel Factors from Fetal Mesenchymal Stem Cell and Their Applications in Bone and Cartilage Repair Secreted α-Klotho maintains cartilage tissue homeostasis by repressing NOS2 and ZIP8-MMP13 catabolic axis Extracellular vesicles and their miRNA cargo in ageing and age-associated diseases The Pathobiology of Osteoarthritis in Obesity: The Role of Synovial Inflammation, Joint Insulin Resistance, and Dysbiosis of the Gut Microbiome Osteobiology of aging PTEN enhances nasal epithelial cell resistance to TNFα‑induced inflammatory injury by limiting mitophagy via repression of the TLR4‑JNK‑Bnip3 pathway Recent advances in understanding cross-talk between Bile Acids and Gut Microbiota. Open J Proteom Genom 3 (1): 024-034 Interleukin 1 gene polymorphism and susceptibility to disease Age-dependent increase in angiopoietin-like protein 2 accelerates skeletal muscle loss in mice Patent Highlights February–March 2018 Microbiome and NAFLD: potential influence of aerobic fitness and lifestyle modification Advances in Therapeutic Approaches to Extend Healthspan: a perspective from the 2nd Scripps Symposium on the Biology of Aging Workshop on Synergies Between Alzheimer’s Research and Clinical Gerontology and Geriatrics: Current Status and Future Directions WSB1 overcomes oncogene-induced senescence by targeting ATM for degradation A double-blind, randomized trial on the effect of a broad-spectrum dietary supplement on key biomarkers of cellular aging including inflammation, oxidative … Innate and adaptive immunity in atherosclerosis Functional interaction between melatonin signaling and noncoding RNAs Shared molecular and cellular mechanisms of premature ageing and ageing-associated diseases Nicotinamide Phosphoribosyltransferase In Smooth Muscle Cells And Aortic Integrity Analysis of Aortic Valve Function in the Absence of Endothelial Retinoblastoma Protein Oxidative stress and the epigenetics of cell senescence: Insights from progeroid syndromes The RNA world of human ageing A system for the expression and release of heterologous proteins from the core of Bacillus subtilis spores THE CANCER AND BONE SOCIETY (CABS) ANNUAL CONFERENCE The versatile role of exosomes in cancer progression: diagnostic and therapeutic implications Vascular aging: molecular mechanisms and potential treatments for vascular rejuvenation The interplay between immunity and aging in Drosophila Submission to the British Geriatrics Society Amulree Prize 2017 The cancer and bone society (CABS) annual conference Sheraton indianapolis hotel at keystone crossing. Indianapolis, Indiana. May 4-6, 2017 AAVvector-mediated in vivo reprogramming into pluripotency Age-Related Adverse Inflammatory and Metabolic Changes Begin Early in Adulthood Toll-like receptor-4 signaling pathway in aorta aging and diseases:“its double nature” The Relevance of Induced Pluripotent Stem Cells for the Study of Physiological and Premature Aging Turning Round: Optimizing the Anti-Inflammatory Properties of Equine Bone Marrow Derived Mesenchymal Stem Cells for Osteoarthritis Through Three-Dimensional … Immunomodulatory properties and senescence-associated secretory phenotypes in human mesenchymal stem cell aging Potency of Human Cardiosphere‐Derived Cells from Patients with Ischemic Heart Disease Is Associated with Robust Vascular Supportive Ability Stem cells, scaffolds and small molecules for orthopedic tissue regeneration Cardiac Effects of Antirheumatic Drugs C. Elegans Eats Its Own Intestine to Make Yolk: A Cause of Senescent Polymorbidity Senescence Induced by DNA Demethylating Drugs to Treat Solid Tumors Autophagy-dependent gut-to-yolk biomass conversion generates visceral polymorbidity in aging C. elegans Identification of Molecular Determinants of Cellular Senescence in Cancer and Aging as a model for aging research Old maids: aging and its impact on microglia function Key Age-Imposed Signaling Changes That Are Responsible for the Decline of Stem Cell Function The effect of metformin on absolute telomere length The role of melatonin, a multitasking molecule, in retarding the processes of ageing Chromatin architectural changes during cellular senescence and aging Nuclear translocation of argonaute 2 in cytokine-induced senescence Inflammation and CMV-associated lymphocyte senescence in chronic HIV infection Length-independent telomere damage drives cardiomyocyte senescence VRK1 phosphorylates Tip60 acetyltransferase and promotes its accumulation in response to both DNA damage and mitogens Induced Cell Turnover: A Novel Therapeutic Modality for In Situ Tissue Regeneration Induction de la sénescence endothéliale auriculaire par l’angiotensine II et la thrombine: rôle du stress oxydant et caractérisation du phénotype pro-thrombotique, pro … Gestational chronodisruption leads to persistent changes in the rat fetal and adult adrenal clock and function Induction of atrial endothelial senescence by angiotensin II and thrombin: role of oxidative stress and characterization of pro-thrombotic, pro-adhesive, proteolytic and … Induction of iPS Cell Differentiation Into Connexin26 Positive Cells with Gap Junction Plaques and Characterization of Cochlear Feeder Cell AGE-ASSOCIATED LAMIN-B1 REDUCTION IN THE THYMIC EPITHELIAL CELLS AND ITS ROLE IN THYMIC INVOLUTION The role of epigenetics in renal ageing Cancer and aging-the inflammatory connection The role of melanocyte senescence in skin ageing Restoring the quantity and quality of elderly human mesenchymal stem cells for autologous cell-based therapies Regulation of the Pro-Tumorigenic Senescence-Associated Secretory Phenotype LE POTENTIEL HEPATIQUE DES CELLULES SOUCHES MESENCHYMATEUSES RAJEUNNIES ET DES PROGENITEURS ENDODERMIQUES: CONTRIBUTION … Different transcriptional profiling between senescent and non-senescent human coronary artery endothelial cells (HCAECs) by omeprazole and lansoprazole … Adoptive autophagy activation: a much-needed remedy against chemical induced neurotoxicity/developmental neurotoxicity Aging and Antiaging Strategies Comparison of mesenchymal stem cells obtained by suspended culture of synovium from patients with rheumatoid arthritis and osteoarthritis Antiretroviral Drug Mediated Astrocyte Senescence as a Contributor to HIV-1-Associated Neurocognitive Disorders Senescent Cells Drive Frailty through Systemic Signals Changes in the biochemical taste of cytoplasmic and cell-free DNA are major fuels for inflamm-aging The association between back muscle characteristics and pressure pain sensitivity in low back pain patients Role of pattern recognition receptors of the neurovascular unit in inflamm-aging Hepatic potential of Reversed-age Mesenchymal Stem Cells and Endodermal Progenitors: Contribution of LGR5 and Cdc42 cell signaling pathways Mitochondria in the spotlight of aging and idiopathic pulmonary fibrosis Synthetic lethal treatment strategies for tumor cell senescence ISEV2018 abstract book Aging, Cellular Senescence, and Kidney Fibrosis Sex hormones and immunosenescence Telomerase may paradoxically accelerate aging of the DNA methylome CD36 initiates the secretory phenotype during the establishment of cellular senescence A novel in vitro macrophage senescence model to study macrophaging A novel in vitro macrophage senescence model to study macrophaging Ageing Astrocytes-Implications for Motoneuron Dysfunction and Sarcopenia BMP-7: role and regulation in osteoarthritis Aging and Malignant Hemopathies: A Complex Multistep Process Biomarkers for Identification of the Dormancy Phenotypes Senescence and Quiescence in Malignancy Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) and liver fibrosis: A review Modulating Ageing Anti-Ageing An in vivo and in vitro study of stress-induced senescence in neurones and its role in neurodegeneration Gene Expression, Epigenetics and Ageing German Congress of Laboratory Medicine: 15th Annual Congress of the DGKL (German Society of Clinical Chemistry and Laboratory Medicine) and the 3rd … Aging Mouse Models Reveal Complex Tumor-Microenvironment Interactions in Cancer Progression The role of neutrophils in telomere induced senescence via bystander effects MITOCHONDRIAL STRESS COMMUNICATION IN MAMMALIAN CELLS GATA4-dependent regulation of the secretory phenotype via MCP-1 underlies lamin A-mediated human mesenchymal stem cell aging Sirt1 and Parp1 as epigenome safeguards and microRNAs as SASP -associated signals, in cellular senescence and agingExosome-based immunomodulation during aging: a nano-perspective on inflamm-aging Leukocyte count, systemic inflammation, and health status in older adults: a narrative review Two Conserved Histone H3 Lys9 Demethalases KDM3A and KDM4C Regulate MSCs Senescence Progress Nutrient Sensing, Signaling and Ageing: The Role of IGF-1 and mTOR in Ageing and Age-Related Disease Identification of HSP90 inhibitors as a novel class of senolytics Aging of the Bone Emerging therapies for idiopathic pulmonary fibrosis, a progressive age-related disease PREMATURE IMMUNOSENESCENCE IN WOMEN NEWLY DIAGNOSED WITH BREAST CANCER–ROLE OF EARLY-LIFE STRESS Mitochondria-targeted hydrogen sulfide attenuates endothelial senescence by selective induction of splicing factors HNRNPD and SRSF2 Sex and the Aging Immune System Molecular pathology: the roles of P53 in the oxidative stress and DNA damage responses in chronic liver disease and hepatocellular carcinoma A Computational System for Automated Meta-Analysis of Gene Expression Data Modulating Aged Macrophages and Osteoprogenitors with a Calcium Phosphate Drug Delivery System Examining Autophagy and Mitophagy as Inducible Mechanisms of Cellular Remodelling Proteotoxicity links therapy-induced cancer cell senescence to Alzheimer’s disease Macrophages in M1/M2 states and exposed to amyloid-beta: a RNA-seq analysis in human cells Atorvastatin inhibits inflammatory response, attenuates lipid deposition, and improves the stability of vulnerable atherosclerotic plaques by modulating … Werner Syndrome as a Model of Human Aging Targeted apoptosis of senescent cells restores tissue homeostasis in response to chemotoxicity and aging Cytokine profile of breast cell lines after different radiation doses Exercise and circulating factors associated with skeletal muscle and bone health in older age Microbiota, NASH, HCC and the potential role of probiotics Autophagy and Signaling β-Hydroxybutyrate prevents vascular senescence through hnRNP A1-mediated upregulation of Oct4 Sarcopenia: aging-related loss of muscle mass and function Zinc finger protein ZFP36L1 promotes osteoblastic differentiation but represses adipogenic differentiation of mouse multipotent cells Elucidating the role of metabolic changes in modulating cell fate following treatment with anti-mitotic drugs TGF-β signaling accelerates senescence of human bone-derived CD271 and SSEA-4 double-positive mesenchymal stromal cells Progenitor cells from the adult heart A rising star in pancreatic diseases: pancreatic stellate cells Secretome analysis of testicular peritubular cells as a clue for solving the puzzle of the human spermatogonial stem cell niche Functional Identification of MicroRNAs Counteracting Cellular Senescence The Geriatrician’s Perspective on Surgery in the Geriatric Population Senescence of bone marrow-derived mesenchymal stem cells from patients with idiopathic pulmonary fibrosis The Long Noncoding RNA H19 Controls Endothelial Cell Functions by STAT3 Repression Clinical Implications for Mitochondrial Stress Induced Senescence and Potential Interventions S The effects of aging in the hippocampus and cognitive decline Human Cytomegalovirus as a driving force towards Immunosenescence Hematopoietic Stem Cell Aging and Malignant Hemopathies Role of Autophagy in Liver Regeneration Old age causes de novo intracortical bone remodeling and porosity in mice Aging Kidney and Aging-Related Disease Melatonin rescued interleukin 1β-impaired chondrogenesis of human mesenchymal stem cells Senescence-associated IL-6 and IL-8 cytokines induce a self-and cross-reinforced senescence/inflammatory milieu strengthening tumorigenic capabilities in … Model of Chaperones in Aging Senescent Cells Differentially Translate Senescence-Related mRNAs Via Ribosome Heterogeneity Accumulation of prelamin A drives inflammation in the heart with implications for treatment of inherited and acquired cardiomyopathies Senescence in COPD and its comorbidities Characterizing Senescence in Astrocytes and its Effect on Neurons Barshop Symposium on Aging 2017 Abstracts Role of vascular smooth muscle cell derived-exosomes in age-related vascular amyloidosis Cancer metabolism in space and time: beyond the Warburg effect Melatonin protected cardiac microvascular endothelial cells against oxidative stress injury via suppression of IP3R-[Ca2+]c/VDAC-[Ca2+]m axis by activation of … Tumor Microenvironment, Therapeutic Resistance, and Personalized Medicine Liver regeneration in aged mice: new insights In medio stat virtus: unanticipated consequences of telomere dysequilibrium The contribution of oxidative stress and inflamm-aging in human and equine asthma NR4A1 promotes diabetic nephropathy by activating mff-mediated mitochondrial fission and suppressing parkin-mediated mitophagy DNA damage induced by Strontium-90 exposure at low concentrations in mesenchymal stromal cells: the functional consequences Cardiac ageing: extrinsic and intrinsic factors in cellular renewal and senescence Role of primary cilia in non-dividing and post-mitotic cells The role of cancer-associated fibroblasts and fibrosis in liver cancer Reversibility of chemotherapy-induced senescence is independent of autophagy and a potential model for tumor dormancy and cancer recurrence. Cancer Cells Exploit Notch Signaling To Redefine A Tumor Supportive Cytokine Milieu Programmed cell senescence in skeleton during late puberty Metabolic reprogramming for cancer cells and their microenvironment: Beyond the Warburg Effect SIRT4 interacts with OPA1 and regulates mitochondrial quality control and mitophagy Psychological stress and mitochondria: a conceptual framework Immunosenescence and hurdles in the clinical management of older HIV-patients Stress granules counteract senescence by sequestration of PAI‐1 The power behind the throne: senescence and the hallmarks of cancer The exercise and diet-microbiome paradigm: influences of physical activity and dietary nutrition on the human gut microbiome Empagliflozin rescues diabetic myocardial microvascular injury via AMPK-mediated inhibition of mitochondrial fission The functions and regulation of the PTEN tumour suppressor: new modes and prospects Distribution and molecular characterization of South African Bacillus Anthracis strains and their associated bacteriophages TARGETING ASCT2/SLC1A5 FOR INHIBITION OF CELLULAR GROWTH AND METABOLISM IN TRIPLE-NEGATIVE BREAST CANCER Cellular Senescence and Inflammaging in Age-Related Diseases The gut microbiome and liver cancer: mechanisms and clinical translation BBA-Reviews on Cancer RNA Binding Proteins, Ageing and Caloric Restriction Controlling senescence by PML and PML nuclear bodies Ataxia telangiectasia syndrome: moonlighting ATM ER stress and impaired autophagy flux in neuronal degeneration and brain injury Leukotriene D4 induces cellular senescence in osteoblasts Understanding the Basis of Gene Regulation of Common Complex Diseases by Computational Analysis of Next-generation Sequencing Data Matrix stiffness regulates oxidative stress response of human dermal fibroblasts Inflammation and the Gut-Liver Axis in the Pathophysiology of Cholangiopathies Dendritic Polyglycerol Sulfate Hydrogels as a Potential Viscosupplement for Treatment of Osteoarthritis Bile acids and cancer: direct and environmental-dependent effects INVOSSATM–a cell and gene therapy for osteoarthritis In vitro proinflammatory gene expression predicts in vivo telomere shortening: A preliminary study Enhancer function driving cellular senescence, DNA damage repair, differentiation, and nuclear organization Investigating strategies to boost cutaneous varicella zoster virus-specific immune responses in ageing humans Natural variations in yeast aging reveal genetic and environmental factors Circulating levels of soluble Receptor for Advanced Glycation End-products (sRAGE) decrease with aging and may predict age-related cardiac remodeling Age-associated metabolic reprogramming, oxidative stress response, and cancer progression Impact of age-associated estrogen deficiency on innate immune responses to myocardial ischemic injury in the female rat heart Antioxidant and oxidative stress: A mutual interplay in age-related diseases MicroRNAs deregulation in prostate cancer Vaccination in the elderly: The challenge of immune changes with aging From rapalogs to anti-aging formula Biomarkers of monitoring and functional reserve of physiological systems over time in HIV: expert opinions for effective secondary prevention IDENTIFICATION OF INTRINSIC REGULATORS IN NORMAL AND MALIGNANT HUMAN HEMATOPOIESIS Epigenome-wide DNA methylation and mitochondrial DNA content in relation to in utero PM2.5 exposure l-Carnitine inhibits the senescence-associated secretory phenotype of aging adipose tissue by JNK/p53 pathwayadipose tissue Growth hormone impact on adipose tissue and agingadipose tissue adipose tissue Targeting senescent cells alleviates obesity‐induced metabolic dysfunction adipose tissue Age-Dependent and-Independent Effects of Perivascular adipose tissue and Its Paracrine Activities during Neointima FormationSenolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease Targeting senescence improves angiogenic potential of adipose-derived mesenchymal stem cells in patients with preeclampsia Heparanase upregulation from adipocyte associates with inflammation and endothelial injury in diabetic condition Cellular senescence: at the nexus between ageing and diabetes OBESITY INDUCES MESENCHYMAL STEM CELL SENESCENCE AND DYSFUNCTION Histologic analysis and lipid profiling reveal reproductive age-associated changes in peri-ovarian adipose tissue In vitro model of chronological aging of adipocytes: Interrelationships with hypoxia and oxidation Sympathetic nervous system as a target for aging and obesity-related cardiovascular diseases Senescent cells in the development of cardiometabolic disease Expression of lipogenic markers is decreased in subcutaneous adipose tissue and adipocytes of older women and is negatively linked to GDF15 expressionRelationship between Circulating Protein p53 and High Sensitivity C-Reactive Protein in Central Obesity Men with Inflammaging Extracellular fraction of adipose tissue as an innovative regenerative approach for vitiligo treatmentNormal breast tissue at risk for cancer development: A breast cancer initiating role for mammary adipocytes Age-associated inflammation alters the aging trajectory Life-span Extension Drug Interventions Affect adipose tissue Inflammation in AgingCellular senescence and senescence‐associated T cells as a potential therapeutic target Mitochondrial Uncoupling Protein-2 Is a Putative Link Between Mitochondrial Dysfunction and Fibroblast Senescence in Age-Related Lung Fibrosis Lipotoxicity, aging, and muscle contractility: does fiber type matter? Skeletal muscle as potential central link between sarcopenia and immune senescence Ileal Transposition Increases Pancreatic β Cell Mass and Decreases β Cell Senescence in Diet-Induced Obese Rats ALCAT1 Deficiency Attenuates Obesity Induced Cellular Senescence in P16-3MR Transgenic Mice Short exposure to cold atmospheric plasma induces senescence in human skin fibroblasts and adipose mesenchymal stromal cells Recent advances in understanding tumor stroma-mediated chemoresistance in breast cancer Alteration of Hypoxia-Associated Gene Expression in Replicatively Senescent Mesenchymal Stromal Cells under Physiological Oxygen Level Rejuvenating Strategies of Tissue-specific Stem Cells for Healthy Aging Novel contributors and mechanisms of cellular senescence in hypertension-associated premature vascular aging β Cell Senescence as a Common Contributor to Type 1 and Type 2 Diabetes Obesity and cancer: A mechanistic overview of metabolic changes in obesity that impact genetic instability Age-dependent impairment of adipose-derived stem cells isolated from horses Can physical activity ameliorate immunosenescence and thereby reduce age-related multi-morbidity? Therapeutic Irradiation: Consequences for Bone and Bone Marrow Adipose The Role of the Gut Microbiome and its Derived Mediators in Nonalcoholic Fatty Liver Disease Inflamm-Aging Is Associated with Lower Plasma PTX3 Concentrations and an Impaired Capacity of PBMCs to Express hTERT following LPS Stimulation Impaired immunomodulatory ability of type 2 diabetic adipose-derived mesenchymal stem cells in regulation of inflammatory condition in mixed leukocyte … 3D printing breast tissue models: A review of past work and directions for future work Aged‐senescent cells contribute to impaired heart regeneration Chemotherapy-induced cellular senescence suppresses progression of Notch-driven T-ALL Senescent cells: A new Achilles’ heel to exploit for cancer medicine? The NADase CD38 is induced by factors secreted from senescent cells providing a potential link between senescence and age-related cellular NAD+ decline Bone marrow mesenchymal stem cells: Aging and tissue engineering applications to enhance bone healing The burden of metabolic syndrome on osteoarthritic joints Modulation of senoinflammation by calorie restriction based on biochemical and Omics big data analysis Remodeling the Microenvironment before Occurrence and Metastasis of Cancer Immune senescence and cardiomyopathy associated with obesity The role of cellular senescence in diabetes mellitus and osteoporosis: molecular pathways and potential interventions Filamin B and CD13 Are Components of Senescent Secretomes That May Be Involved in Primary (Stress Induced) and Paracrine Senescence of Mesenchymal … and Ahmet Turan Isik β‐Cell senescence in the pathogenesis of type 2 diabetes Inflammation, Frailty and Cardiovascular Disease Cellular Senescence in the Kidney Heat shock response to exercise in pancreatic islets of obese mice Regulation of senescence and the SASP The Links Between Osteoporosis and Sarcopenia in Women Increased renal cellular senescence in murine high-fat diet: effect of the senolytic drug quercetin Type 2 diabetes is associated with the accumulation of senescent T cells Elimination of senescent osteoclast progenitors has no effect on the age‐associated loss of bone mass in mice Aging-related inflammation driven by cellular senescence enhances NAD consumption via activation of CD38+ pro-inflammatory macrophages Adipokines: New Therapeutic Target for Osteoarthritis? Major depression and enhanced molecular senescence abnormalities in young and middle-aged adults Expansion and cell-cycle arrest: Common denominators of cellular senescence Mechanisms of obesity-induced metabolic and vascular dysfunctions Redefining Chronic Inflammation in Aging and Age-Related Diseases: Proposal of the Senoinflammation Concept Mixing old and young: enhancing rejuvenation and accelerating aging Involvement of adiponectin in age-related increases in tear production in mice LPS-induced premature osteocyte senescence: Implications in inflammatory alveolar bone loss and periodontal disease pathogenesis Emerging roles of and therapeutic strategies targeting BRD4 in cancer In situ evidence of cellular senescence in Thymic Epithelial Cells (TECs) during human thymic involution Cellular senescence in bone Effect of aging on behaviour of mesenchymal stem cells Earlier changes in mice after D-galactose treatment were improved by mitochondria derived small peptide MOTS-c Pleiotropic effect of fibrates on senescence and autophagy in osteoarthritis Low-dose quercetin positively regulates mouse healthspan Microbial metabolites in non-alcoholic fatty liver disease Elevated Local Senescence in Diabetic Wound Healing Is Linked to Pathological Repair via CXCR2 The potential role of senescence in limiting fibrosis caused by aging Metabolic Alterations in Aging Macrophages: Ingredients for Inflammaging? Protective role of polyphenols against vascular inflammation, aging and cardiovascular disease TGF-β Signaling in Cellular Senescence and Aging-Related Pathology Obesity-induced cellular senescence drives anxiety and impairs neurogenesis Reduced subcutaneous adipogenesis in human hypertrophic obesity is linked to senescent precursor cells Targeting normal and cancer senescent cells as a strategy of senotherapy Senescent and apoptotic osteocytes and aging: Exercise to the rescue? Senotherapeutics: Emerging strategy for healthy aging and age-related disease Extracellular vesicles circulating in young organisms promote healthy longevity Effectiveness of stage by stage bariatric interventions for regression of comorbidity at obese class III patients L1 drives IFN in senescent cells and promotes age-associated inflammation The STATus of STAT3 in Lung Cell Senescence? Intraarticular senescent chondrocytes impair the cartilage regeneration capacity of mesenchymal stem cells Senescent dermal fibroblasts negatively influence fibroblast extracellular matrix‐related gene expression partly via secretion of complement factor D Mitochondria and cellular senescence: Implications for musculoskeletal ageing Age and Frailty as Risk Factors for the Development of Osteoarthritis The biology of frailty in humans and animals: Understanding frailty and promoting translation Turning back time with emerging rejuvenation strategies Senescence and senotherapeutics: A new field in cancer therapy Senescence marker activin A is increased in human diabetic kidney disease: association with kidney function and potential implications for therapy The Safe and Efficacious Use of Secretome From Fibroblasts and Adipose-derived (but not Bone Marrow-derived) Mesenchymal Stem Cells for Skin … Cellular Senescence and the Immune System in Cancer Advanced liver steatosis accompanies an increase in hepatic inflammation, colonic, secondary bile acids and Lactobacillaceae/ KRAS, YAP, and obesity in pancreatic cancer: A signaling network with multiple loops Chronic inflammation in the etiology of disease across the life span Pan-senescence transcriptome analysis identified RRAD as a marker and negative regulator of cellular senescence Flavonoids: Broad Spectrum Agents on Chronic Inflammation Astrocyte senescence in an Alzheimer’s disease mouse model is mediated by TGF-β1 and results in neurotoxicity mTOR as a central regulator of lifespan and aging Vascular Diseases and Gangliosides Muscle-derived miR-34a increases with age in circulating extracellular vesicles and induces senescence of bone marrow stem cells Aging and lineage allocation changes of bone marrow skeletal (stromal) stem cells Looking for immortality: Review of phytotherapy for stem cell senescence Gangliosides Contribute to Vascular Insulin Resistance Emerging senolytic agents derived from natural products Vitamin E: Regulatory Role on Signal Transduction Experimental strategies of mesenchymal stem cell propagation: Adverse events and potential risk of functional changes Introductory Chapter: Nonalcoholic Fatty Liver Disease-What Should We Know? The role of probiotics in nonalcoholic fatty liver disease: a new insight into therapeutic strategies Cellular senescence and chronological age in various human tissues: A systematic review and meta‐analysis Nrf2 exerts mixed inflammation and glucose metabolism regulatory effects on murine RAW264. 7 macrophages Chronic Low-grade Inflammatory Phenotype (CLIP) and Senescent Immune Dysregulation Obesity May Accelerate the Aging Process Manufacturing of primed mesenchymal stromal cells for therapy Pyrroloquinoline quinone prevents estrogen deficiency-induced osteoporosis by inhibiting oxidative stress and osteocyte senescence Obesity is a common soil for premature cardiac aging and heart diseases-role of autophagy Culinary medicine: advancing a framework for healthier eating to improve chronic disease management and prevention Mesenchymal stem cell senescence alleviates their intrinsic and seno-suppressive paracrine properties contributing to osteoarthritis development Senescence in the lung: is this getting old? TGF-β mediates aortic smooth muscle cell senescence in Marfan syndrome Cellular senescence in cardiac diseases Bone marrow niches for skeletal progenitor cells and their inhabitants in health and disease Potential role of senescence in radiation-induced damage of the aged skeleton The kynurenine pathway: a finger in every pie Cell aging and cellular senescence in skin aging—Recent advances in fibroblast and keratinocyte biology The Senescent Cell, SC Mitochondria-driven elimination of cancer and senescent cells Use of MSCs in Antiaging Strategies Dynamic role of the codon 72 p53 single-nucleotide polymorphism in mammary tumorigenesis in a humanized mouse model Promotion and induction of liver cancer by gut microbiome-mediated modulation of bile acids Cellular cross-talks in the diseased and aging heart Conditioned Medium of Mesenchymal Stromal Cells: A New Class of Therapeutics Coexisting frailty with heart failure Barshop Symposium on Aging 2018 Abstracts Amitosenescence and Pseudomitosenescence: Putative New Players in the Aging Process HIF1α‐mediated AIMP3 suppression delays stem cell aging via the induction of autophagy Inflammaging as a common ground for the development and maintenance of sarcopenia, obesity, cardiomyopathy and dysbiosis Inflammation: a common contributor to cancer, aging, and cardiovascular diseases—expanding the concept of cardio-oncology Inflammation as a mediator of arterial ageing LINE-1 derepression in senescent cells triggers interferon and inflammaging Cells exhibiting strong p16INK4a promoter activation in vivo display features of senescence Early vascular ageing and cellular senescence in chronic kidney disease Childhood obesity and leucocyte telomere length Cell-Free Culture Supernatant of Probiotic Lactobacillus fermentum Protects Against H2O2-Induced Premature Senescence by Suppressing ROS-Akt-mTOR Axis in … Raman fingerprints as promising markers of cellular senescence and aging Where Metabolism Meets Senescence: Focus on Endothelial Cells Exercise Training for the Elderly: Inflammaging and the Central Role for HSP70 Proteomic analysis of human mesenchymal stromal cell secretomes: a systematic comparison of the angiogenic potential BubR1 allelic effects drive phenotypic heterogeneity in mosaic-variegated aneuploidy progeria syndrome Quantifying Senescence-Associated Phenotypes in Primary Multipotent Mesenchymal Stromal Cell Cultures Roles of JAK2 in aging, inflammation, hematopoiesis and malignant transformation Independent Roles of Estrogen Deficiency and Cellular Senescence in the Pathogenesis of Osteoporosis: Evidence in Young Adult Mice and Older Humans Cellular senescence in arterial diseases 25-Hydroxyvitamin D3 positively regulates periodontal inflammaging via SOCS3/STAT signaling in diabetic mice Inflammation, Infection and Atherosclerosis Obesity-Associated Hypermetabolism and Accelerated Senescence of Bone Marrow Stromal Stem Cells Suggest a Potential Mechanism for Bone Fragility Chronic whole-body heat treatment relieves atherosclerotic lesions, cardiovascular and metabolic abnormalities, and enhances survival time restoring the anti … The chemistry of senescence Stem Cell Senescence: the Obstacle of the Treatment of Degenerative Disk Disease Autophagy Dysfunction, Cellular Senescence, and Abnormal Immune-Inflammatory Responses in AMD: From Mechanisms to Therapeutic Potential Breast tissue biology expands the possibilities for prevention of age-related breast cancers Senescent cell clearance by the immune system: Emerging therapeutic opportunities Metformin and Aging: A Review Non-Alcoholic Fatty Liver Disease, and the Underlying Altered Fatty Acid Metabolism, Reveals Brain Hypoperfusion and Contributes to the Cognitive Decline in APP … Senile Osteoporosis: The Involvement of Differentiation and Senescence of Bone Marrow Stromal Cells Muscle and Bone Biology–Similarities and Differences COPD as a Disease of Immunosenescence Sex hormones and anticancer immunity Targeting chronic innate inflammatory pathways, the main road to prevention of osteoarthritis progression Autofluorescence is a Reliable in vitro Marker of Cellular Senescence in Human Mesenchymal Stromal Cells Methionine restriction delays senescence and suppresses the senescence-associated secretory phenotype in the kidney through endogenous hydrogen sulfide Identification of Aberrantly Expressed Genes during Aging in Rat Nucleus Pulposus Cells Role of the Gut–Liver Axis in Liver Inflammation, Fibrosis, and Cancer: A Special Focus on the Gut Microbiota Relationship Type 2 diabetes: how much of an autoimmune disease? Urine-Derived Stem Cells Secreting Small Extracellular Vesicles Loaded in Acellular Amniotic Membrane for Wound Healing Promotion in Aged Mice Type 2 Diabetes: How Much of an Autoimmune Disease? Fasting and rapamycin: diabetes versus benevolent glucose intolerance Roles of the Immune System in the Development and Progression of Hepatocellular Carcinoma Genetic Stability of Mesenchymal Stromal Cells for Regenerative Medicine Applications: A Fundamental Biosafety Aspect Regulation of cellular senescence by retinoid X receptors and their partners Secretome of Mesenchymal Stem Cells and its Impact on Chronic Obstructive Pulmonary Disease Defective induction of the proteasome associated with T‐cell receptor signaling underlies T‐cell senescence Lifestyle and Food Habits Impact on Chronic Diseases: Roles of PPARs When the skin is in the center of interest-An aging issue New frontiers in osteoporosis therapy Aging and Cardiovascular Diseases: The Role of Cellular Senescence Oxidative Stress and Non-Alcoholic Fatty Liver Disease: Effects of Omega-3 Fatty Acid Supplementation Efficacy of 3D Culture Priming is Maintained in Human Mesenchymal Stem Cells after Extensive Expansion of the Cells Potential Mechanisms of 3, 4-Oxo-Isopropylidene-Shikimic Acid in Ameliorating 2, 4, 6-Trinitrobenzenesulfonic Acid-Induced Colitis in Rats Principal Criteria for Evaluating the Quality, Safety and Efficacy of hMSC-Based Products in Clinical Practice: Current Approaches and Challenges The clinical impact and biological mechanisms of skeletal muscle aging Chronic Kidney Disease and the Vascular Endothelium Current Knowledge and New Challenges in Exercise Immunology Aspirin ameliorates the long‐term adverse effects of doxorubicin through suppression of cellular senescence Aging, Immunity, and Neuroinflammation: The Modulatory Potential of Nutrition Perspectives of the International Society of Cell & Gene Therapy Gastrointestinal Scientific Committee on the Intravenous Use of Mesenchymal Stromal Cells in … Cellular senescence: aging, cancer, and injury Searching for the Holy Grail Will Need Biomarkers DNA damage response manages cell cycle restriction of senile multipotent mesenchymal stromal cells The role of mitochondria-derived peptides in cardiovascular disease: Recent updates Tackling Aging by Using miRNA as a Target and a Tool Selective elimination of senescent cells by mitochondrial targeting is regulated by ANT2 Premature aging and cancer development in transgenic mice lacking functional CYLD Obesity-Induced Sympathoexcitation is Associated with Nrf2 Dysfunction in the Rostral VentroLateral Medulla Senescence‐induced immunophenotype, gene expression and electrophysiology changes in human amniocytes The senescence-associated secretory phenotype and its regulation An early‐senescence state in aged mesenchymal stromal cells contributes to hematopoietic stem and progenitor cell clonogenic impairment through the activation of a … Extracellular vesicles and redox modulation in aging Survival of aging CD264+ and CD264− populations of human bone marrow mesenchymal stem cells is independent of colony‐forming efficiency Seno-suppressive molecules as new therapeutic perspectives in rheumatic diseases Identification of senescent cells in multipotent mesenchymal stromal cell cultures: current methods and future directions The ING1a model of rapid cell senescence The key players of tumor microenvironment and their role in breast cancer Skin barrier immunity and ageing Integration of heterogeneous functional genomics data in gerontology research to find genes and pathway underlying aging across species Metabolic requirements of human pro-inflammatory B cells in aging and obesity Aging and bone Control of Inflammation by Calorie Restriction Mimetics: On the Crossroad of Autophagy and Mitochondria PGC1α repression in IPF fibroblasts drives a pathologic metabolic, secretory and fibrogenic state Loss of epitranscriptomic control of selenocysteine utilization engages senescence and mitochondrial reprogramming☆ The Molecular Physiology of Ageing: New Targets for Regenerative Medicine Knockdown of angiopoietin-like 2 induces clearance of vascular endothelial senescent cells by apoptosis, promotes endothelial repair and slows … Obesity and Hepatocarcinogenesis Lifestyle Choices, Psychological Stress and Their Impact on Ageing: The Role of Telomeres Mechanisms of Calorie Restriction: A Review of Genes Required for the Life-Extending and Tumor-Inhibiting Effects of Calorie Restriction Exosomes may be the potential new direction of research in osteoarthritis management Mitochondrial protection partly mitigates kidney cellular senescence in swine atherosclerotic renal artery stenosis Molecular insights into Hutchinson-Gilford progeria syndrome and age-associated disease: from mechanisms to treatment strategy Rapid detection of senescent mesenchymal stromal cells by a fluorescent probe Iron and iron-dependent reactive oxygen species in the regulation of macrophages and fibroblasts in non-healing chronic wounds Low‐Dose Pesticide Mixture Induces Accelerated Mesenchymal Stem Cell Aging In Vitro Maternal Sleep in Pregnancy and Postpartum Part II: Biomechanisms and Intervention Strategies Hydroxyurea‐induced Senescent Peripheral Blood Mesenchymal Stromal Cells Inhibit Bystander Cell Proliferation of JAK2V617F‐positive Human Erythroleukemia … Doxorubicin and liposomal doxorubicin induce senescence by enhancing nuclear factor kappa B and mitochondrial membrane potential The Upregulation of Toll-Like Receptor 3 via Autocrine IFN-β Signaling Drives the Senescence of Human Umbilical Cord Blood-Derived Mesenchymal Stem … Myeloid-derived suppressor cells: not only in tumor immunity Moderate hyperoxia induces senescence in developing human lung fibroblasts Senolytics and senostatics as adjuvant tumour therapy The link between endometrial stromal cell senescence and decidualization in female fertility: the art of balance Melatonin attenuates renal fibrosis in diabetic mice by activating the AMPK/PGC1α signaling pathway and rescuing mitochondrial function Molecular taxonomy of osteoarthritis for patient stratification, disease management and drug development: biochemical markers associated with emerging clinical … Differential Expression of Human N-Alpha-Acetyltransferase 40 (hNAA40), Nicotinamide Phosphoribosyltransferase (NAMPT) and Sirtuin-1 (SIRT-1) Pathway … Regulation of inflammation as an anti‐aging intervention Aiding and Abetting: How the Tumor Microenvironment Protects Cancer from Chemotherapy Relationships between ion channels, mitochondrial functions and inflammation in human aging Targeting senescent cells in translational medicine Recent insights into the multiple pathways driving nonalcoholic steatohepatitis-derived hepatocellular carcinoma Aging, sex, inflammation, frailty, and CMV and HIV Infections Low-grade inflammation causes gap junction-coupled cell dysfunction throughout the body, which can lead to the spread of systemic inflammation The upregulation of Toll-like receptor 3 via autocrine IFN-beta signaling drives the senescence of human mesenchymal stem cells through JAK1 Pak2 kinase promotes cellular senescence and organismal aging Molecular Pathogenesis of Oral Submucous Fibrosis: A Critical Appraisal Mechanisms of aging and potential role of selected polyphenols in extending healthspan The role of lipids in aging-related metabolic changes Emerging Role of Stem cell-derived Extravesicular MicroRNAs in Age-associated Human Diseases and in Different Therapies of Longevity The genetics of human ageing Inflammation in osteoarthritis: is it time to dampen the alarm (in) in this debilitating disease? Estrogen deprivation triggers an immunosuppressive phenotype in breast cancer cells Liver and Steroid Hormones—Can a Touch of p53 Make a Difference? Impacts of the late adulthood diet-induced obesity onset on behavior, immune function, redox state and life span of male and female mice The Mediterranean Diet Slows Down the Progression of Aging and Helps to Prevent the Onset of Frailty: A Narrative Review Exosome: Advanced Development and a Novel Therapeutic Strategy for Osteoarthritis and Cartilage Injury Diabetes drugs in the fight against Alzheimer’s disease Patient-Derived Organoids from Human Bile: An In Vitro Method to Study Cholangiopathies The Aging Thyroid: A Reappraisal Within the Geroscience Integrated Perspective Immune Modulation by Transplanted Calcium Phosphate Biomaterials and Human Mesenchymal Stromal Cells in Bone Regeneration Bone marrow-derived mesenchymal stem cells in three-dimensional co-culture attenuate degeneration of nucleus pulposus cells Roles of sleep deprivation in cardiovascular dysfunctions micro (RNA)-managing muscle wasting Stem cell derived exosomes: microRNA therapy for age-related musculoskeletal disorders Astrocyte senescence: Evidence and significance FGF21 Mediates Mesenchymal Stem Cell Senescence via Regulation of Mitochondrial Dynamics Aging and the Biological Response to Liver Injury Age-Related Thymic Atrophy: Mechanisms and Outcomes The Effects of Early-Life Drug and Dietary Interventions on Late-Life Disease Development Preclinical Evidence for the Role of Stem/Stromal Cells in COPD Melatonin attenuates myocardial ischemia‐reperfusion injury via improving mitochondrial fusion/mitophagy and activating the AMPK‐OPA1 signaling pathways Therapeutic effect of n-butanol fraction of Huang-lian-Jie-du Decoction on ulcerative colitis and its regulation on intestinal flora in colitis mice Future Cell and Gene Therapy for Osteoarthritis (OA): Potential for Using Mammalian Protein Production Platforms, Irradiated and Transfected Protein … Gut microbiota in liver disease: too much is harmful, nothing at all is not helpful either Embryonic stem cell-derived extracellular vesicles enhance the therapeutic effect of mesenchymal stem cells Tumor microenvironment-driven non-cell-autonomous resistance to antineoplastic treatment Pharmacology of metformin–An update Restoring mechano-adaptation in aged murine bone Slowing Down Ageing: The Role of Nutrients and Microbiota in Modulation of the Epigenome Integrating cellular senescence with the concept of damage accumulation in aging: Relevance for clearance of senescent cells Mechanistic complexities of bone loss in Alzheimer’s disease: a review Investigation on Spectrum-Effect Correlation between Constituents Absorbed into Blood and Bioactivities of Baizhu Shaoyao San before and after Processing on … Lifelong aerobic exercise protects against inflammaging and cancer Distinct effects of epirubicin, cisplatin and cyclophosphamide on ovarian somatic cells of prepuberal ovaries The Emerging Role of Exosomal Non-coding RNAs in Musculoskeletal Diseases Mitochondria in the signaling pathways that control longevity and health span Crosstalk between P53 and DNA Damage Response in Ageing Diabetic gut microbiota dysbiosis as an inflammaging and immunosenescence condition that fosters progression of retinopathy and nephropathy Dual faced HMGB1 plays multiple roles in cardiomyocyte senescence and cardiac inflammatory injury Melatonin and chromatin Mst1 facilitates hyperglycemia-induced retinal pigmented epithelial cell apoptosis by evoking mitochondrial stress and activating the Smad2 signaling pathway Circular RNA CircCCNB1 sponges micro RNA-449a to inhibit cellular senescence by targeting CCNE2 Failure of immunosurveillance accelerates aging Rationally-based therapeutic disease modification in systemic sclerosis: Novel strategies Extracellular vesicles in human skin: cross-talk from senescent fibroblasts to keratinocytes by miRNAs Pharmacodynamics OF TNF α inhibitors for the treatment of psoriasis Integrated Theories of Biological Aging Organismal Aging and Oxidants Beyond Macromolecules Damage<? Qry msg=” Please provide author biographies for up to three authors (each biography not … The Role of Curcumin in the Modulation of Ageing The Impending Epidemic of Cardiovascular Diseases in Patients With Cancer in Japan Pro-and anti-tumorigenic functions of the senescence-associated secretory phenotype Silencing of long noncoding RNA HOXA11-AS inhibits the Wnt signaling pathway via the upregulation of HOXA11 and thereby inhibits the proliferation … Novel clinico-molecular insights into the role of bisphenol-A (BPA) in the etiology of diabetes Mitochondria and aging—The role of exercise as a countermeasure A novel form of Deleted in breast cancer 1 (DBC1) lacking the N-terminal domain does not bind SIRT1 and is dynamically regulated in vivo INJURY SENESCENCE OF THE IMMUNE SYSTEM Directed elimination of senescent cells attenuates development of osteoarthritis by inhibition of c-IAP and XIAP Loss of SATB1 Induces p21-Dependent Cellular Senescence in Post-mitotic Dopaminergic Neurons Moving beyond the current limits of data analysis in longevity and healthy lifespan studies Cellular senescence and the kidney: potential therapeutic targets and tools The Biology of Senescence The clock is ticking: the impact of ageing on T cell metabolism Ribosomal DNA instability: an evolutionary conserved fuel for inflammaging Role of microRNA-141 in the aging musculoskeletal system: a current overview Activation of immunosuppressive network in the aging process Senescence cell–associated extracellular vesicles serve as osteoarthritis disease and therapeutic markers Molecular biology of acute and chronic inflammation Transcriptomic analysis reveals the mechanism of sulfasalazine-induced liver injury in mice Inflammatory bone marrow microenvironment Cell and Gene Therapy for Spine Regeneration: Mammalian Protein Production Platforms for Overproduction of Therapeutic Proteins and Growth Factors Interleukin-17 and senescence regulate the foreign body response Nuclear-encoded Mitochondrial Genetic Variation in Human Aging and Longevity Transient introduction of human telomerase mRNA improves hallmarks of progeria cells DNA Damage Induced Cell Fates during Aging Chromosomal instability and pro-inflammatory response in aging Understanding the role of chondrocytes in osteoarthritis: utilizing proteomics Emerging Roles of Complement Protein C1q in Neurodegeneration Growth hormone in the tumor microenvironment NAD+ Metabolism in Aging and Cancer Cellular Stress and General Pathological Processes A prospect of cell immortalization combined with matrix microenvironmental optimization strategy for tissue engineering and regeneration The expression of P16 and S100 associated with elastin degradation and fibrosis of the Ligamentum Flavum hypertrophy Risk Factors for Frailty and Cardiovascular Diseases: Are They the Same? MicroRNAs in the Functional Defects of Skin Aging Aging, Melatonin, and the Pro-and Anti-Inflammatory Networks Huang-Lian-Jie-Du decoction ameliorates acute ulcerative colitis in mice via regulating NF-κB and Nrf2 signaling pathways and enhancing intestinal barrier function Cellular senescence in cultured human brainstem astrocytes: Effect of oxidative stress A murine aging cell atlas reveals cell identity and tissue-specific trajectories of aging Exosomal long noncoding RNAs in aging and age‐related diseases Cellular senescence in the lung across the age spectrum Modulation of Human Neutrophil Peptides on P. aeruginosa Killing, Epithelial Cell Inflammation and Mesenchymal Stromal Cell Secretome Profiles Stabilizing heterochromatin by DGCR8 alleviates senescence and osteoarthritis Alpha-1 Antitrypsin Deficiency and Accelerated Aging: A New Model for an Old Disease? ERR agonism reverses mitochondrial dysfunction and inflammation in aging Senescent hepatocytes in decompensated liver show reduced UPRMT and its key player, CLPP, attenuates senescence in vitro Thrombin Induces Angiotensin II-Mediated Senescence in Atrial Endothelial Cells: Impact on Pro-Remodeling Patterns Preventive role of Resveratrol against inflammatory cytokines and related diseases Towards a unified mechanistic theory of aging Iguratimod: a valuable remedy from the Asia Pacific region for ameliorating autoimmune diseases and protecting bone physiology Autophagy and Immune Tolerance Investigating the role of microRNAs in the hypoxic response in prostate cancer Clinical Inference of Serum and Bone Sclerostin Levels in Patients with End-Stage Kidney Disease Healthy aging: A bibliometric analysis of the literature Danger signals and inflammaging in osteoarthritis Length‐independent telomere damage drives post‐mitotic cardiomyocyte senescence Orexins as novel therapeutic targets in inflammatory and neurodegenerative diseases Skin Health from the Inside Out SFRR-E 2019 ANNUAL MEETING “REDOX HOMEOSTASIS: FROM SIGNALING TO DAMAGE” Oleuropein, a Bioactive Compound from Olea europaea L., as a Potential Preventive and Therapeutic Agent in Non-Communicable Diseases Interleukin-1 and related cytokines in the regulation of inflammation and immunity Plenary Sessions Premature aging syndromes: From patients to mechanism Understanding the origin and diversity of macrophages to tailor their targeting in solid cancers Oxytocin Alleviates Cellular Senescence through Oxytocin Receptor‐Mediated ERK/Nrf2 Signalling Inflammation and cancer: triggers, mechanisms, and consequences Probiotic bacteria as modulators of cellular senescence: emerging concepts and opportunities Immunobiology of atherosclerosis: a complex net of interactions Beneficial effect of physical exercise on telomere length and aging, and genetics of aging-associated noncommunicable diseases Inflammaging and oxidative stress in human diseases: from molecular mechanisms to novel treatments Candesartan Neuroprotection in Rat Primary Neurons Negatively Correlates with Aging and Senescence: a Transcriptomic Analysis Methylglyoxal Acts as a Tumor-Promoting Factor in Anaplastic Thyroid Cancer The potential role of necroptosis in inflammaging and aging Multidimensional informatic deconvolution defines gender-specific roles of hypothalamic GIT2 in aging trajectories Enhancement of epithelial cell autophagy induced by sinensetin alleviates epithelial barrier dysfunction in colitis Age-related inflammation triggers skeletal stem/progenitor cell dysfunction Quantitative proteomic analyses in blood: A window to human health and disease The bystander effect contributes to the accumulation of senescent cells in vivo. Inhibition of JAK-STAT Signaling with Baricitinib Reduces Inflammation and Improves Cellular Homeostasis in Progeria Cells Antioxidative nanomaterials and biomedical applications Health Benefits of Anti-aging Drugs Exercise and dietary interventions in a rat model of metabolic knee osteoarthritis Tissue Engineering and Regenerative Medicine Therapies for Cell Senescence in Bone and Cartilage Placental Ageing in Adverse Pregnancy Outcomes: Telomere Shortening, Cell Senescence, and Mitochondrial Dysfunction Regulatory mechanisms and clinical manifestations of musculoskeletal aging Sex Steroids, Cognate Receptors, and Aging Epigenetic changes during aging and their reprogramming potential NAD+ therapy in age-related degenerative disorders: A benefit/risk analysis Premature cell senescence in human skin: dual face in chronic acquired pigmentary disorders 140-3D Hydrogels and Bioinks for Realistic In Vitro Modelling and Bioprinting Impact of aging on bone, marrow and their interactions FRI0531 THE ARTICULAR PROTECTION EFFECT OF ISORHAMNETIN IN THE RATS OF MONOSODIUM IODOACETATE-INDUCED OSTEOARTHRITIS Benefits of tree nuts consumption on aging and age-related diseases: mechanisms of actions Regulation of Wound Healing by the NRF2 Transcription Factor—More Than Cytoprotection Enhancement of therapeutic efficacy by immunomodulation in human mesenchymal stem cells PAK4 signaling in development and cancer Transposable Elements, Inflammation and Neurological Disease Drugs that target aging: how do we discover them? Extracellular matrix roles in cardiorenal fibrosis: Potential therapeutic targets for CVD and CKD in the elderly Murine models of accelerated aging and musculoskeletal disease Identification of differentially expressed transcription factors and dissecting the role of DREAM complex associated components in cellular senescence Inflammation and Liver Cancer: Molecular Mechanisms and Therapeutic Targets Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer’s disease model Acquired Immune Response to Infection MHY2233 Attenuates Replicative Cellular Senescence in Human Endothelial Progenitor Cells via SIRT1 Signaling Methods to Quantify the NF-κB Pathway During Senescence Somatic mutations in healthy cells and age-associated diseases HER2 recruits AKT1 to disrupt STING signalling and suppress antiviral defence and antitumour immunity Investigating the immune system in chrONIC kidney disease-the SONIC study JOINT MEETING AGI–SIMAG Rejuvenation: Turning back the clock of aging kidney Characterisation of an in vitro aged cell culture model L1CAM and its role in cellular senescence The role of the cell-matrix interface in aging and its interaction with the renin-angiotensin system in the aged vasculature Time for the systems-level integration of aging: Resilience enhancing strategies to prevent Alzheimer’s disease Epigenetics and Pharmacoepigenetics of Age-Related Neurodegenerative Disorders Molecular basis of senescence transmitting in the population of human endometrial stromal cells Shared and distinct mechanisms of fibrosis Skeletal Muscle Stem Cells Are There Reliable Biomarkers for Immunosenescence and Inflammaging? Epidermal growth factor (EGF) intralesional infiltrations: from the bench to the diabetic ulcers cells Senescence surveillance: the interplay between the immune system and senescent cells Exosomes as Emerging Pro-Tumorigenic Mediators of the Senescence-Associated Secretory Phenotype Age-Associated Changes in the Immune System and Blood–Brain Barrier Functions Recent advances in understanding the phenotypes of osteoarthritis Inducing Age Related Changes in Microglia as a Model for Neurodegenerative Disease Convallatoxin protects against dextran sulfate sodium-induced experimental colitis in mice by inhibiting NF-κB signaling through activation of PPARγ Innate immune cell crosstalk induces melanoma cell senescence Characterization and Analysis of Neural Progenitor Cells from Primary Progressive Multiple Sclerosis Patients Targeting Cell Senescence for the Treatment of Age-Related Bone Loss Ell3 functions as a critical decision maker at the crossroad between stem cell senescence and apoptosis The role of exosomes in regenerative medicine Mitochondrial dysfunction and cell senescence: deciphering a complex relationship The Effects of IL-1β on Astrocytes are Conveyed by Extracellular Vesicles and Influenced by Age The role of senescence in cancer development 41th Volume Index The proteome of ulcerative colitis-Functional analyses of the active disease and the remission state in comparison with healthy controls Allostatic load and ageing: linking the microbiome and nutrition with age-related health Rosiglitazone ameliorates senescence and promotes apoptosis in ovarian cancer induced by olaparib Novel insights of elevated systemic levels of bisphenol-A (BPA) linked to poor glycemic control, accelerated cellular senescence and insulin resistance in patients with … Methods for CPP Functionalization Probing the impact of the maternal environment on foetal development: Can high-resolution telomere analysis predict prenatal adversity? Bone marrow stromal cells from β-thalassemia patients have impaired hematopoietic supportive capacity Recurrent circadian fasting (RCF) improves blood pressure, biomarkers of cardiometabolic risk and regulates inflammation in men Noncoding RNAs: Bridging Regulation of Circadian Rhythms and Inflammation Accelerated cardiomyocyte senescence contributes to late-onset doxorubicin-induced cardiotoxicity. SEXUAL ABUSE: HOW CAN WE KNOW? Metabolic phenotyping of the human microbiome Reduced RNA turnover as a driver of cellular senescence The role of metabolism in the anti-tumor cytotoxicity of natural killer cells Microncronucleus index in epithelial exfoliated cells of urothelium and buccal mucosa, and peripheral blood lymphocytes of patients with papillary urothelial … Transient non-integrative nuclear reprogramming promotes multifaceted reversal of aging in human cells Senolytic activity of small molecular polyphenols from olive restores chondrocyte redifferentiation and cartilage regeneration in osteoarthritis PTEN loss regulates alveolar epithelial cell senescence in pulmonary fibrosis depending on Akt activation Mitophagy, Mitochondrial Dynamics, and Homeostasis in Cardiovascular Aging TGF-β in Hepatic Stellate Cell Activation and Liver Fibrogenesis—Updated 2019 Know your enemy: Genetics, aging, exposomic and inflammation in the war against triple negative breast cancer NAD+ in brain aging and neurodegenerative disorders Prelamin A mediates myocardial inflammation in dilated and HIV-associated cardiomyopathies miR-140 Attenuates the Progression of Early-Stage Osteoarthritis by Retarding Chondrocyte Senescence The dark side of fibroblasts: cancer-associated fibroblasts as mediators of immunosuppression in the tumor microenvironment The role of signaling pathways of inflammation and oxidative stress in development of senescence and aging phenotypes in cardiovascular disease Emerging targets of disease-modifying therapy for systemic sclerosis Identification and characterization of inter-species aging-related transcriptomic regulators Mouse Models of Accelerated Cellular Senescence Cranberries–potential benefits in patients with chronic kidney disease Mitochondrial Homeostasis and Cellular Senescence Amelioration of age‐related brain function decline by Bruton’s tyrosine kinase inhibition NLRP3 inflammasome suppression improves longevity and prevents cardiac aging in male mice Paeonol prevents IL-1β-induced inflammatory response and degradation of type II collagen in human primary chondrocytes Scarless wound healing: From development to senescence β cell responses to inflammation The modular proteome and its significance Activated Fibroblast Program Orchestrates Tumor Initiation and Progression; Molecular Mechanisms and the Associated Therapeutic Strategies Ferroptosis, a new form of cell death: opportunities and challenges in cancer Senescence-associated metabolomic phenotype in primary and iPSC-derived mesenchymal stromal cells Leukocyte Telomere Length in Patients with Radiographic Knee Osteoarthritis Concepts in Inflammatory Bowel Disease Management Protein Signatures of Centenarians and Their Offspring Suggest Centenarians Age Slower than Other Humans Tumor microenvironment: Interactions and therapy The TGF-β1/p53/PAI-1 Signaling Axis in Vascular Senescence: Role of Caveolin-1 Stromal cell-derived factor-1 (CXCL12) and its role in bone and muscle biology Measuring biological aging in humans: A quest Amelioration of Ductular Reaction by Stem Cell Derived Extracellular Vesicles in MDR2 Knockout Mice via Lethal‐7 microRNA Activation of melatonin receptor 2 but not melatonin receptor 1 mediates melatonin‐conferred cardioprotection against myocardial ischemia/reperfusion injury Proteomic Markers for Depression Induction of Fibroblast Senescence During Mouse Corneal Wound Healing Regulation of Thirst and Vasopressin Release Hyper-osmolarity environment-induced oxidative stress injury promotes nucleus pulposus cell senescence in vitro Novel drug targets in idiopathic pulmonary fibrosis Sleep, stress, and immunity Meeting report: Metastasis Research Society (MRS) 17th Biennial conference and associated Young Investigator Satellite Meeting (YISM) on cancer metastasis Targeting pro-senescence mitogen activated protein kinase (Mapk) enzymes with bioactive natural compounds Coordination of immune-stroma crosstalk by IL-6 family cytokines Long non-coding RNA CDKN2B-AS1 reduces inflammatory response and promotes cholesterol efflux in atherosclerosis by inhibiting ADAM10 expression Proceedings of the 2018 Santa Fe Bone Symposium: Advances in the Management of Osteoporosis The telomere world and aging: Analytical challenges and future perspectives The cross-talk between sphingolipids and insulin-like growth factor signaling: significance for aging and neurodegeneration Young Hematopoietic Stem Cells Ameliorate Age-Associated Phenotypes and Extend Lifespan in Mice MicroRNA networks modulate oxidative stress in cancer The RXFP3 receptor is functionally associated with cellular responses to oxidative stress and DNA damage Crosstalk between HGF and TGF-ß signaling pathways in adult liver progenitor cells and hepatocellular carcinoma cells The Evolving Role of CD8+ CD28− Immunosenescent T Cells in Cancer Immunology Astrocytes autophagy in aging and neurodegenerative disorders Stem cells: a path towards improved epilepsy therapies Novel function of PiT1/SLC20A1 in LPS-related inflammation and wound healing Biomarkers of Aging (With a Clinical Potential in Oncology) Mitochondrial oxidative stress-induced transcript variants of ATF3 mediate lipotoxic brain microvascular injury MOTOR BEHAVIOR Mediterranean Diet (Prong-4) Resveratrol: A New Potential Therapeutic Agent for Melanoma? EFFECT OF ADVANCED MATERNAL AGE ON PREGNANCY
