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    ALLERGIES & CYTOKINES
    February 16, 2020
    Epigenetic Modifiers
    February 17, 2020

    Evading apoptosis in cancer

    Carcinogenesis is a mechanistically complex and variable process with a plethora of underlying genetic causes. Cancer development consists of a multitude of steps that occur progressively starting with initial driver mutation(s), to tumorigenesis, and ultimately metastasis. During these transitions, cancer cells accumulate a series of genetic alterations that confer upon the cells an unwarranted survival and proliferative advantage. During the course of development, however, cancer cells also encounter a physiologically ubiquitous cellular program that aims to eliminate damaged or abnormal cells: Apoptosis. Thus, it is essential that cancer cells acquire instruments to circumvent programmed cell death. Here we discuss emerging evidence indicating how cancer cells adopt various strategies to override apoptosis including amplifying the anti-apoptotic machinery, downregulating the pro-apoptotic program, or both.

    Roles of Apoptosis and Cellular Senescence in Cancer and Aging.

    Cancer and aging are two similar processes representing the final outcome of timedependent accumulation of various irreversible dysfunctions, mainly caused by stress-induced DNA and cellular damages. Apoptosis and senescence are two types of cellular response to damages that are altered in both cancer and aging, albeit through different mechanisms. Carcinogenesis is associated with a progressive reduction in the ability of the cells to trigger apoptosis and senescence. In contrast, in aging tissues, there is an increased accumulation of senescent cells, and the nature of apoptosis deregulation varies depending on the tissue. Thus, the prevailing model suggests that apoptosis and cellular senescence function as two essential tumor-suppressor mechanisms, ensuring the health of the individual during early and reproductive stages of life, but become detrimental and promote aging later in life. The recent discovery that various anticancer agents, including canonical inducers of apoptosis, act also as inducers of cellular senescence indicates that pro-senescence strategies may have applications in cancer prevention therapy. Therefore, dissection of the mechanisms mediating the delicate balance between apoptosis and cellular senescence will be beneficial in the therapeutic exploitation of both processes in the development of future anticancer and anti-aging strategies, including minimizing the side effects of such strategies. Here, we provide an overview of the roles of apoptosis and cellular senescence in cancer and aging.

    Cellular senescence (CS) is initially defined as an irreversible growth arrest of normal somatic cells, and has been proposed to contribute to tissue and organismal aging itself, and to be an intrinsic safeguard against tumor progression (1). SCs have been shown to have diverse phenotypes, including cellular flattening and hypertrophy, senescence-associated β-galactosidase activity (SAβG), senescence-associated secretory phenotype (SASP), resistance to apoptotic cell death, alterations in nuclear structure and senescence-associated heterochromatic foci (SAHF), mitochondrial expansion, and signaling events, including upregulation of cell cycle inhibitors and -pro-survival effectors (2). SCs accumulated in various tissues in mice with age, and comprised 5–40% of the total cells, depending on the tissue types (3). Although their number are relatively small in tissues, SCs can cause extensive dysfunction of the microenvironment and damage to surrounding cells and tissues, due to their pro-inflammatory senescence-associated secretory phenotype (SASP). Accumulating evidence suggests that CS plays an important role in diverse biological processes, such as embryonic development, diabetes, host immunity, wound healing, tissue renewal, as well as fibrosis, cardiovascular diseases, and cancer (4).

    Since aging is one of major risk factors of human diseases, a variety of aging interventions have been developed to extend health span and to prevent or treat ARDs in in vitro and in vivoexperimental models. Caloric restriction (CR) is the only intervention shown to increase health span as well as to decrease the risk of ARDs in nonhuman primates (5). Recently, clinical trials of CR in non-obese humans revealed that a 15% lower calorie intake for 2 years delayed metabolism accompanied by reduced oxidative damage, suggesting that CR could also slow down the aging process in humans (6). Although CR can enhance healthy aging, the inconvenience of most subjects to maintain CR for a longtime limits its application. Therefore, caloric restriction mimetics (7), and calorie restriction diets or fasting-mimicking diets (8) have been proposed as alternatives. Elucidation of the mechanisms by which aging is regulated also suggested a variety of compounds and medicines, including sirtuin activators (9), AMP dependent protein kinase (AMPK) activators (10), mammalian target of rapamycin (mTOR) inhibitors (11), autophagy activators (12), that might be applicable for use in aging intervention. In addition, the use of geroprotectors, compounds and medicines that slow down aging, and thus lengthen the lifespan of model organisms has also been proposed (13). In present, a curated database of geroprotectors is available, and includes 259 compounds in 13 animal models from yeast to human, obtained from 2,408 literature (http://geroprotectors.org/). An old story tells the rejuvenation effects of young blood. Heterochronic parabiosis, in which an aged mouse and a young one were joined surgically, revealed that some factors in young blood, such as growth differentiation factor 11 with controversial reports and oxytocin enhanced tissue regeneration, and led to improvement of aging phenotypes (14). Similarly, transfusion of young serum also retarded age-related impairments in cognitive function and synaptic plasticity in aged mice (15, 16).

    Although CS is one of hallmarks of aging (17), and accumulation of SCs with age has been suggested to be associated with aging and ARDs (18), direct evidence of a causal relationship between CS and aging or ARDs has only recently been validated in rodent models. Furthermore, senotherapeutics, have been implicated as novel strategies for aging intervention in applications designed to extend healthy aging and to prevent or treat ARDs.

    1. A Balance Between Nf-Y And P53 Governs The Pro-And Anti-Apoptotic Transcriptional Response
    2. A Balance Between The Anti-Apoptotic Activity Of Slug And The Apoptotic Activity Of Msx1 Is Required For The Proper Development Of The Neural Crest
    3. A Biodesign Approach To Obtain High Yields Of Biosimilars By Anti-Apoptotic Cell Engineering: A Case Study To Increase The Production Yield Of Anti-Tnf Alpha Producing …
    4. A Commentary On” Tgf-[Beta] 1-Induced Expression Of The Anti-Apoptotic Pai-1 Protein Requires Egfr Signaling”
    5. A Commentary On” Tgf-Pi-Induced Expression Of The Anti-Apoptotic Pai-1 Protein Requires Egfr Signaling”
    6. A Comprehensive Study Of A Novel Anti-Apoptotic Gene, Bre
    7. A Conserved Mechanism For Binding Of P53 Dna-Binding Domain And Anti-Apoptotic Bcl-2 Family Proteins
    8. A Critical Role For Anti-Apoptotic C-Iap2 Gene In Lps And Tnf-A-Induced Resistance To Hiv-Vpr Mediated Apoptosis In Human Monocytic Cell
    9. A Critical Role For The Anti-Apoptotic Protein Arc (Apoptosis Repressor With Card) In Hypoxia-Induced Pulmonary Hypertension
    10. A Death Receptor-Associated Anti-Apoptotic Protein, Bre, Inhibits Mitochondrial Apoptotic Pathway
    11. A Dna Vaccine Co-Expressing Antigen And An Anti-Apoptotic Molecule Further Enhances The Antigen-Specific Cd8+ T-Cell Immune Response
    12. A Dual Role For The Anti-Apoptotic Bcl-2 Protein In Cancer: Mitochondria Versus Endoplasmic Reticulum
    13. A Fluorescence Based Method For Studying The Membrane Topology Of The Anti-Apoptotic Protein Bcl-Xl
    14. A Functional Erythropoietin Receptor In A Rat Heart Is Linked To Anti-Apoptotic Effects
    15. A Functional Microrna Library Screen Reveals Mir-410 As A Novel Anti-Apoptotic Regulator Of Cholangiocarcinoma
    16. A Functional Yeast Survival Screen Of Tumor-Derived Cdna Libraries Designed To Identify Anti-Apoptotic Mammalian Oncogenes
    17. A Genetic Variant Of The Anti-Apoptotic Protein Akt Predicts Natalizumab-Induced Lymphocytosis And Post-Natalizumab Multiple Sclerosis Reactivation
    18. A Gip Receptor Agonist Exhibits Β-Cell Anti-Apoptotic Actions In Rat Models Of Diabetes Resulting In Improved Β-Cell Function And Glycemic Control
    19. A Hydrophobic Core Sequence Of Anti-Apoptotic Protein Bcl-2 Inserts Into A Model Membrane In An Α Helical Conformation
    20. A Inhibits Sodium Nitroprusside-Induced Cardiac H9C2 Cell Death Through Suppressing Activation Of Jnk And Preserving Mitochondrial Anti-Apoptotic Bcl-2 And Mcl-1
    21. A Lentiviral Expression System Demonstrates That L* Protein Of Theiler’S Murine Encephalomyelitis Virus (Tmev) Has An Anti-Apoptotic Effect In A Macrophage Cell Line
    22. A Link Between The Interleukin‐6/Stat3 Anti‐Apoptotic Pathway And Microrna‐21 In Preimplantation Mouse Embryos
    23. A Male Infertility Mutation Reverts Nanos1 Activity From Anti-Apoptotic To Pro-Apoptotic By Disrupting Repression Of Gadd45A, Gadd45B, Gadd45G And Rhob Genes
    24. A Mechanism Of Atf5 Anti-Apoptotic Action That Promotes Leukemia Cells Survival
    25. A Member Of The Gage Family Of Tumor Antigens Is An Anti-Apoptotic Gene That Confers Resistance To Fas/Cd95/Apo-1, Interferon-G, Taxol And G-Irradiation
    26. A Monoclonal Antibody Targeted To The Functional Peptide Of Αb-Crystallin Inhibits The Chaperone And Anti-Apoptotic Activities
    27. A Multi-Component Herbal Preparation, Stw 5, Shows Anti-Apoptotic Effects In Radiation Induced Intestinal Mucositis In Rats
    28. A Multimeric Model For Murine Anti-Apoptotic Protein Bcl-2 And Structural Insights For Its Regulation By Post-Translational Modification.
    29. A Multi-Spectroscopic, Computational And Molecular Modeling Studies On Anti-Apoptotic Proteins With Boc-D-Lys-Oh
    30. A Natural Compound Elevates Expression Of Bim That Interacts With Bcl-2 Converting The Anti-Apoptotic Protein To A Pro-Apoptotic Bax-Like Molecule
    31. A New Angiotensin Ii Type I Receptor Blocker, Br-A-657, Reduces Reperfusion Injury Via Anti-Apoptotic/Anti-Inflammatory Effect.
    32. A New Insight Into Meat Toughness Of Callipyge Lamb Loins-The Relevance Of Anti-Apoptotic Systems To Decreased Proteolysis
    33. A New Role For The Anti-Apoptotic Gene A20 In Angiogenesis
    34. A Novel Allosteric Mechanism For Molecular Inhibition Of Anti-Apoptotic Mcl-1
    35. A Novel Anti‐Apoptotic Role For Apolipoprotein L2 In Ifn‐Γ‐Induced Cytotoxicity In Human Bronchial Epithelial Cells
    36. A Novel Anti-Apoptotic Role Of Dmp1 In Normal And Pathological Conditions
    37. A Novel Antibody Blocks Anti-Apoptotic Activity Of Muc1 In Pancreatic Cancer Cell Lines
    38. A Novel Approach To Increase Breast Cancer Cell Chemosensitivity: Disuption Of The Anti-Apoptotic Function Of Translation Factor Eif4E
    39. A Novel Approach To Increase Breast Cancer Chemosensitivity: Disruption Of The Anti-Apoptotic Function Of Translation Factor Eif4E
    40. A Novel Bh 3 Mimetic Efficiently Induces Apoptosis In Melanoma Cells Through Direct Binding To Anti‐Apoptotic Bcl‐2 Family Proteins, Including Phosphorylated Mcl‐1
    41. A Novel Indole Ethyl Isothiocyanate (7Me-Ieitc) With Anti-Proliferative And Pro-Apoptotic Effects On Platinum-Resistant Human Ovarian Cancer Cells
    42. A Novel Parthenin Analog Exhibits Anti-Cancer Activity: Activation Of Apoptotic Signaling Events Through Robust No Formation In Human Leukemia Hl-60 Cells
    43. A Novel Protein, Rtn-X S, Interacts With Both Bcl-X L And Bcl-2 On Endoplasmic Reticulum And Reduces Their Anti-Apoptotic Activity
    44. A Novel Resveratrol Analog: Its Cell Cycle Inhibitory, Pro-Apoptotic And Anti-Inflammatory Activities On Human Tumor Cells
    45. A Novel Selectivity Determinant Informs The Development Of Next-Generation Stapled Peptide Inhibitors Of Anti-Apoptotic Bfl-1/A1
    46. A Plausible Anti-Apoptotic Role Of Up-Regulated Oct4B1 In Bladder Tumors
    47. A Potential Mechanism For The Anti-Apoptotic Property Of Koumine Involving Mitochondrial Pathway In Lps-Mediated Raw 264.7 Macrophages
    48. A Preliminary Study Of The Anti-Inflammatory And Anti-Apoptotic Effects Of Crocin Against Gastric Ischemia-Reperfusion Injury In Rats
    49. A Protein Kinase Cϵ-Anti-Apoptotic Kinase Signaling Complex Protects Human Vascular Endothelial Cells Against Apoptosis Through Induction Of Bcl-2
    50. A Rac1/Phosphatidylinositol 3-Kinase/Akt3 Anti-Apoptotic Pathway, Triggered By Alsinlf, The Product Of The Als2 Gene, Antagonizes Cu/Zn-Superoxide Dismutase …
    51. A Ratiometric Fluorescent Probe For Imaging And Quantifying Anti-Apoptotic Effects Of Gsh Under Temperature Stress
    52. A Review Of The Regulatory Role Of Nicotinamide On Pro-And Anti-Apoptotic Proteins In Neuronal Cells
    53. A Role Of P301L Tau Mutant In Anti-Apoptotic Gene Expression, Cell Cycle And Apoptosis
    54. A Selective Inhibitor Of Drp1, Mdivi-1, Acts Against Cerebral Ischemia/Reperfusion Injury Via An Anti-Apoptotic Pathway In Rats
    55. A Single Amino Acid Change (Asp 53→ Ala53) Converts Survivin From Anti-Apoptotic To Pro-Apoptotic
    56. A Study Of An Anti-Apoptotic Modulator Present In Alcelaphine Herpesvirus-1
    57. A Study On Apoptosis And Anti-Apoptotic Status In Wilson Disease
    58. A Study On Mechanism Of Anti-Apoptotic Effect Of Electroacupuncture In Acute Local Cerebral Ischemia-Re Perfusion Rats
    59. A Survey Of The Anti-Apoptotic Bcl-2 Subfamily Expression In Cancer Types Provides A Platform To Predict The Efficacy Of Bcl-2 Antagonists In Cancer Therapy
    60. A Synthetic Podophyllotoxin Derivative Exerts Anti-Cancer Effects By Inducing Mitotic Arrest And Pro-Apoptotic Er Stress In Lung Cancer Preclinical Models
    61. A Three-Genes Signature Of Anti-Apoptotic Genes Showed Different Mechanisms In Preventing Apoptosis In Acute Myeloid Leukemia Cells And Could Provide An …
    62. A1 Is A Growth-Permissive Anti-Apoptotic Factor Mediating Post-Activation
    63. A2. 3 Anti-Apoptotic Igg Antibodies From Patients With Primary Sjögren’S Syndrome And Systemic Lupus Erythematosus Inhibit The Phagocytosis Of Apoptotic Cells
    64. Aav-Mediated Combination Therapy Of Neurotrophic And Anti-Apoptotic Factors In A Mouse Model Of Inherited Retinal Degeneration
    65. Aberrantly Activated Anti‐Apoptotic Signalling Mechanisms In Chronic Lymphocytic Leukaemia Cells: Clues To The Identification Of Novel Therapeutic Targets
    66. Ability Of Breast Cancer Cell Lines To Stimulate Bone Resorbing Activity Of Mature Osteoclasts Correlates With An Anti-Apoptotic Effect Mediated By Macrophage Colony …
    67. Abnormal Expression Of Anti-Apoptotic Gene Xiap In Chronic Lymphocytic Leukemia And Its Clinical Significance
    68. Abnormal Surfactant Protein Expression And Activation Of Anti-Apoptotic pathways In Severe Interstitial Lung Disease (Ild) In Rubinstein-Taybi Syndrome (Rts)
    69. Abstract A30: Dysregulation Of Bmi1 And Microrna-16 Collaborate To Enhance An Anti-Apoptotic Potential In The Side Population Of Refractory Mantle Cell Lymphoma
    70. Abstract Ap14: Pooled Genomic Screens Identify Anti-Apoptotic Genes As Mediators Of Chemotherapy Resistance In Ovarian Cancer
    71. Abstract B03: The Ews/Fli Oncogene Exerts Pro-Migratory And Anti-Apoptotic Effects Via Dysregulation Of Focal Adhesion Kinase (Fak) Signaling In Ewing Sarcoma
    72. Abstract B09: Targeting The Anti-Apoptotic Protein Mcl-1 With The Mtor Inhibitor Rad001 Sensitizes Luminal Breast Cancers To The Bcl-2/Bcl-Xl Inhibitor Abt-263
    73. Abstract Lb-79: Synergistic Anticancer Effects Of The 9.2. 27Pe Immunotoxin And Abt-737 In Melanoma Involves Silencing Of The Anti-Apoptotic Protein Mcl-1
    74. Abstract P127: A Viral Anti-Apoptotic Serpin, Serp-2, Inhibits Plaque Growth In A Mouse Aortic Transplant Model: Inhibition Of Transplant Vasculopathy Is Granzyme B …
    75. Abstract P4-01-07: Endoplasmic Reticulum-Associated Calcium Regulates Resistance Of The Anti-Apoptotic Protein Bcl-2 To Taxol-Induced Apoptosis In Breast Cancer …
    76. Abstract P5-03-06: Overcoming Mek Inhibitor Resistance In Triple-Negative Breast Cancer By Targeting Myeloid Cell Leukemia-1 (Mcl1), An Anti-Apoptotic Protein
    77. Abstract P6-14-05: A Novel Link Between Anti-Apoptotic Signaling, Nfκb, And Smad7 In Ibc Pathobiology
    78. Abstract Wmp27: Selective Cerebral Vasodilatation And Anti-Apoptotic Therapy With Shockwave-Induced Release Of Nitric Oxide Using Nano Au-Polymersomes/S …
    79. Abstract# 2038: F-Box Protein 10: A Novel Anti-Apoptotic Protein Regulates Trail-Induced Apoptosis
    80. Abstract# 2218: Leptin Induces Migration Of Breast Cancer Cells Via Upregulation Of Anti-Apoptotic Protein, Survivin
    81. Abstract# 3257: Identification Of Interaction Of Anti-Apoptotic Protein Bcl-2 With The Small Gtpase Rac1: A Possible Bh3 Domain-Mediated Binding And Regulation At The …
    82. Abstract# 3279: Omacetaxine Induces The Rapid Loss Of Anti-Apoptotic Short-Lived Proteins In Bcr-Abl Positive Cells
    83. Abstract# 3867: Degradation Of The Anti-Apoptotic Protein Mcl-1 Correlates With Mitotic Cell Death In Response To The Novel Ksp Inhibitor Arry-520.
    84. Abstract# 4583: Ccl25 Blockade Inhibits Anti-Apoptotic Signals In Prostate Cancer Cells And Enhances Cytotoxic Effects Of Etoposide
    85. Abstract# 475: Human Rif1 Encodes An Anti-Apoptotic Factor Required For Dna Repair
    86. Abt-263 Sensitizes Trail-Resistant Hepatocarcinoma Cells By Downregulating The Bcl-2 Family Of Anti-Apoptotic Protein
    87. Abundant Anti‐Apoptotic Bcl‐2 Is A Molecular Target In Leukaemias With T (4; 11) Translocation
    88. Ac154 Carried Out Anti-Apoptotic Role During Acmnpv Infection Process In The Host Insect Cells
    89. Acetone Fraction Of The Red Marine Alga Laurencia Papillosa Reduces The Expression Of Bcl-2 Anti-Apoptotic Marker And Flotillin-2 Lipid Raft Marker In Mcf-7 Breast …
    90. Acetylation Of Lysine 92 Improves The Chaperone And Anti-Apoptotic Activities Of Human Αb-Crystallin
    91. Acetylcholine Has An Anti-Apoptotic Effect On Fas-Induced Apoptosis In Human Keratocytes
    92. Acid Administered At Various Time Points Protects Against Cerebral Infarction By Activating P38 Mapk/P90Rsk/Creb/Bcl-2 Anti-Apoptotic Signaling In The …
    93. Acidic Leucine-Rich Nuclear Phosphoprotein 32 Family Member B (Anp32B), A Novel Caspase-3 Substrate, Exerts Anti-Apoptotic Effects On Acute Myeloid Leukemic …
    94. Acidosis Sensing Receptor Gpr65 Correlates With Anti-Apoptotic Bcl-2 Family Member Expression In Cll Cells: Potential Implications For The Cll …
    95. Acquired Alkylating Drug Resistance Of A Human Ovarian Carcinoma Cell Line Is Unaffected By Altered Levels Of Pro-And Anti-Apoptotic Proteins
    96. Acquired Tamoxifen Resistance And Overexpression Of Anti-Apoptotic Molecules: A Potential Strategy For Overcoming Endocrine Resistance
    97. Acquisition Of Anti-Apoptotic Potential In The Process Of Telomerase-Mediated Immortalizaion Of Human Fetal Lung Fibroblasts
    98. Acrylamide-Induced Apoptosis In Macrophages: Anti-Apoptotic Role Of Atf3
    99. Acth Inhibits A Ras-Dependent Anti-Apoptotic And Mitogenic Pathway In Mouse Y1 Adrenocortical Cells
    100. Activated Apoptotic And Anti‐Survival Effects On Rat Hearts With Fructose Induced Metabolic Syndrome
    101. Activated Cdc42 Kinase Is An Anti-Apoptotic Signal In Drosophila Melanogaster
    102. Activated Protein C Exert Its Anti-Apoptotic Activity Mediates Via Parp Inhibition Against Oxygen-Glucose Deprivation In Cultured Neuronal Cells (P5. 129)
    103. Activated Protein C Protects Against Diabetic Nephropathy In Vivo Via Its Anti-Apoptotic Properties
    104. Activated Protein C Protects Myocardium Via Activation Of Anti-Apoptotic pathways Of Survival In Ischemia-Reperfused Rat Heart
    105. Activating Enzyme Inhibitor Pevonedistat Induces Er Stress/Upr-Mediated Cell Death And Rebalances Homeostasis Of Pro-And Anti-Apoptotic Proteins In Favor Of …
    106. Activation Of Amp-Activated Protein Kinase Α1 Alleviates Endothelial Cell Apoptosis By Increasing The Expression Of Anti-Apoptotic Proteins Bcl-2 And Survivin
    107. Activation Of Ampk/Mnsod Signaling Mediates Anti-Apoptotic Effect Of Hepatitis B Virus In Hepatoma Cells
    108. Activation Of Autophagy Mediates Insulin-Like Growth Factor I (Igf-1)-Induced Anti-Apoptotic Effect In Vascular Smooth Muscle Cells
    109. Activation Of Nf-Κb And Upregulation Of Intracellular Anti-Apoptotic Proteins Via The Igf-1/Akt Signaling In Human Multiple Myeloma Cells: Therapeutic …
    110. Activation Of Pro‐Survival Akt And Erk1/2 Signalling pathways Underlie The Anti‐Apoptotic Effects Of Flavanones In Cortical Neurons
    111. Activation Of Stat5 Triggers Proliferation And Contributes To Anti-Apoptotic Signalling Mediated By The Oncogenic Xmrk Kinase
    112. Activation Of The Anti-Apoptotic Akt/Protein Kinase B Pathway In Human Malignant Gliomas In Vivo.
    113. Activation Of The Ras Signaling Pathway Promotes The Over-Expression Of Anti-Apoptotic Heme Oxygenase-1 In Human Renal Cancer
    114. Active Celiac Disease Induces An Anti-Apoptotic Phenotype Which Limits Apoptosis
    115. Activity Of Cydonia Oblonga Flower Petals, Leaf And Fruit Pellet Ethanolic Extracts. Docking Simulation Of The Active Flavonoids On Anti-Apoptotic Protein Bcl-2
    116. Acute Alcohol Effects On Cardiac Pro-And Anti-Apoptotic pathways In The Perfused Adult Rat Heart
    117. Acute And Long-Term Neuronal Loss Induced By Perinatal Asphyxia: Activation Of Pro-Apoptotic, Anti-Apoptotic And Sentinel Proteins
    118. Acute Effects Of Haemodialysis On Pro-/Anti-Apoptotic Genes In Peripheral Blood Leukocytes
    119. Acute Myeloid Leukaemia Cells Specifically By Activation Of Caspases And Break Radio-And Chemoresistance By Inhibition Of The Anti-Apoptotic Proteins X-Linked …
    120. Acute Myeloid Leukemia Possessing Jumping Translocation Is Related To Highly Elevated Levels Of Eat/Mcl-1, A Bcl-2 Related Gene With Anti-Apoptotic Functions
    121. Acute Organ Failure Following The Loss Of Anti-Apoptotic Cellular Flice-Inhibitory Protein Involves Activation Of Innate Immune Receptors
    122. Acute Sensitization Of Leukemia Cells To Vinblastine By Small-Molecule Inhibitors Of Anti-Apoptotic Bcl-2 Family Proteins
    123. Acute Thermal Stress And Various Heavy Metals Induce Tissue-Specific Pro-Or Anti-Apoptotic Events Via The P38-Mapk Signal Transduction Pathway In Mytilus …
    124. Adaphostin Disrupts Mitogenic And Anti-Apoptotic Signaling By Npm-Alk In Anaplastic Large Cell Lymphomas
    125. Adaptation Of Hepg2 Cells To Silver Nanoparticles-Induced Stress Is Based On The Pro-Proliferative And Anti-Apoptotic Changes In Gene Expression
    126. Adaptation To Chronic Continuous Hypoxia Potentiates Akt/Hk2 Anti-Apoptotic Pathway During Brief Myocardial Ischemia/Reperfusion Insult
    127. Adiol Protects Against 3-Np-Induced Neurotoxicity In Rats: Possible Impact Of Its Anti-Oxidant, Anti-Inflammatory And Anti-Apoptotic Actions
    128. Adipocyte-Secreted Factors Synergistically Promote Mammary Tumorigenesis Through Induction Of Anti-Apoptotic Transcriptional Programs And Proto-Oncogene …
    129. Adiponectin Exerts Cardioprotection Against Ischemia/Reperfusion Injury Partially Via Calreticulin Mediated Anti-Apoptotic And Anti-Oxidative Actions
    130. Adiponectin Exhibits Proliferative And Anti-Apoptotic Effects On Ovarian Cancer Cells Via Pi3K/Akt And Raf/Mek/Erk Pathways
    131. Adiponectin Protects Against Doxorubicin-Induced Cardiomyopathy By Anti-Apoptotic Effects Through Ampk Up-Regulation
    132. Adipose-Derived Stem Cells (Adscs) Delay The Process Of Retinal Degeneration In Rcs Rats By Anti-Apoptotic Mechanisms
    133. Adjunctive Xiap Anti-Apoptotic Therapy In Pdeβ Gene-Replacement Therapy In The Retinal Degeneration 10 (Rd10) Mouse
    134. Administration Of Glucocorticoids To Ovarian Cancer Patients Is Associated With Expression Of The Anti-Apoptotic Genes Sgk1 And Mkp1/Dusp1 In Ovarian Tissues
    135. Adrenomedullin Is Anti‐Apoptotic In Osteoblasts Through Cgrp1 Receptors And Mek‐Erk Pathway
    136. Aerobic Exercise Training Induces An Anti-Apoptotic Milieu In Myocardial Tissue
    137. Against Cholestasis And Ischemia In Vitro By Ursodeoxycholyl Lysophosphatidylethanolamide (Udca-Lpe) Is Associated With Upregulation Of Anti-Apoptotic Proteins
    138. Akt Has An Anti-Apoptotic Role In Abca12-Deficient Keratinocytes
    139. Akt Mediates The Anti‐Apoptotic Effect Of Nmda But Not That Induced By Potassium Depolarization In Cultured Cerebellar Granule Cells
    140. Akt Pathway Is Activated By 1, 25-Dihydroxyvitamin D3 And Participates In Its Anti-Apoptotic Effect And Cell Cycle Control In Differentiating Hl60 Cells
    141. Akt Plays A Central Role In The Anti-Apoptotic Effect Of Estrogen In Endothelial Cells
    142. Akt/Bcl-2 Signaling Is Critical For Anti-Apoptotic Effects Of Carbon Monoxide (Co) Against Tnf-Alpha-Mediated Inflammatory Damage In Cerebral Vascular Endothelial …
    143. Akt‐Mediated Anti‐Apoptotic Effects Of Substance P In Anti‐Fas‐Induced Apoptosis Of Human Tenocytes
    144. Alanyl-Glutamine Heals Indomethacin-Induced Gastric Ulceration In Rats Via Antisecretory And Anti-Apoptotic Mechanisms
    145. Allicin Attenuates Global Cerebral Ischemia/Reperfusion Injury In Gerbils Via Anti-Oxidative And Anti-Apoptotic Pathway
    146. Aloperine Attenuates Hydrogen Peroxide‑Induced Injury Via Anti‑Apoptotic Activity And Suppression Of The Nuclear Factor‑Κb Signaling Pathway
    147. Alteration Of Pro-Apoptotic And Anti-Apoptotic Gene Expression In Breast Cancer Cell Lines
    148. Alteration Of Pro-Apoptotic And Anti-Apoptotic Gene Expression In Breast Cancer Cell Lines (1047.7)
    149. Alterations In The Expression Of The Anti-Apoptotic Factor Hax-1 Upon Seizures-Induced Hippocampal Injury In The Neonatal Rat Brain
    150. Altered Expression Of Anti–And Pro–Apoptotic Genes In Rpe65–/–Mouse Model Of Leber’S Congenital Amaurosis
    151. Altered Expression Of Anti-Apoptotic Proteins In Non-Involved Tissue From Cancer-Containing Breasts
    152. Amelioration Of Diabetes By Imatinib Mesylate (Gleevec®): Role Of Β-Cell Nf-Κb Activation And Anti-Apoptotic Preconditioning
    153. Amentoflavone Enhances The Therapeutic Efficacy Of Sorafenib By Inhibiting Anti-Apoptotic Potential And Potentiating Apoptosis In Hepatocellular Carcinoma In Vivo
    154. Amentoflavone Induces Apoptosis And Inhibits Nf-ĸb-Modulated Anti-Apoptotic Signaling In Glioblastoma Cells
    155. Amentoflavone Induces Apoptosis And Reduces Expression Of Anti-Apoptotic And Metastasis-Associated Proteins In Bladder Cancer
    156. An Alternative Mechanism For Melatonin’S Protective Effects On Metal Ion Toxicity–Modulation Of Pro-/Anti-Apoptotic Proteins
    157. An Anti-Apoptotic B-Cell Lymphoma-2 (Bcl-2) From Channa Striatus: Sequence Analysis And Delayed And Advanced Gene Expression In Response To Fungal, Bacterial …
    158. An Anti-Apoptotic Bcl-2 Family Protein Index Predicts The Response Of Leukemic Cells To The Pan-Bcl-2 Inhibitor S1.
    159. An Anti-Apoptotic Hek293 Cell Line Provides A Robust And High Titer Platform For Transient Protein Expression In Bioreactors
    160. An Anti-Apoptotic Molecule, Anamorsin, Functions In Both Iron-Sulfur Protein Assembly And Cellular Iron Homeostasis
    161. An Anti-Apoptotic Molecule, Anamorsin, Is Essential For Erythropoiesis Through The Regulation Of Cellular Labile Iron Pool
    162. An Anti-Apoptotic Molecule, Anamorsin, Is Upregulated In Anemia And Essential For Imperative Erytropoiesis
    163. An Anti-Apoptotic Pattern Correlates With Multidrug Resistance In Acute Myeloid Leukemia Patients: A Comparative Study Of Active Caspase-3, Cleaved Parps, Bcl-2 …
    164. An Anti-Apoptotic Peptide Improves Survival In Lethal Total Body Irradiation
    165. An Anti—Apoptotic Protein Expressed Specifically And Highly In The Cardiac Tissue: Arc
    166. An Anti-Apoptotic Protein Human Survivin Is A Direct Inhibitor Of Caspase-3 And-7
    167. An Anti-Apoptotic Protein, Bre, Promotes Growth Of Chemically-Induced Mouse Hepatocellular Carcinoma
    168. An Anti‐Apoptotic Protein, Hax‐1, Inhibits The Hiv‐1 Rev Function By Altering Its Sub‐Cellular Localization
    169. An Anti-Apoptotic Role For Galectin-3 In Diffuse Large B-Cell Lymphomas
    170. An Anti-Apoptotic Role For Gastrin In Barrett’S Oesophagus
    171. An Anti-Apoptotic Role For Ngf Receptors In Human Rhabdomyosarcoma
    172. An Anti-Apoptotic Role For The P53 Family Member, P73, During Developmental Neuron Death
    173. An Anti-Apoptotic Role Of Nf-Κb In Tnfα-Induced Apoptosis In An Ameloblastoma Cell Line
    174. An Anti-Apoptotic Viral Protein That Recruits Bax To Mitochondria
    175. An Anti-Parkinson’S Disease Drug, N-Propargyl-1 (R)-Aminoindan (Rasagiline), Enhances Expression Of Anti-Apoptotic Bcl-2 In Human Dopaminergic Sh-Sy5Y Cells
    176. An Approach To Breast Cancer Immunotherapy: The Apoptotic Activity Of Recombinant Anti‐Interleukin‐6 Monoclonal Antibodies In Intact Tumour Microenvironment Of …
    177. An Epstein-Barr Virus Anti-Apoptotic Protein Constitutively Expressed In Transformed Cells And Implicated In Burkitt Lymphomagenesis: The Wp/Bhrf1 Link
    178. An Extremely Weak Electric Current System Induces Anti-Apoptotic Effects And Anti-Necrotic Effects In Living Cells
    179. An Immunolohistochemical Study Of Anti-Apoptotic Bcl-2 In The Pig’S Oviduct During The Oestrous Cycle
    180. An In Silico Analysis Of Physicochemical Characterization And Protein-Protein Interaction Network Analysis Of Human Anti-Apoptotic Proteins
    181. An In-Vitro Method To Study Anti-Apoptotic Signaling From The Extracellular Environment
    182. An Involvement Of Bdnf And Pi3-K/Akt In The Anti-Apoptotic Effect Of Memantine On Staurosporine-Evoked Cell Death In Primary Cortical Neurons
    183. An Optically Pure Apogossypolone Derivative As Potent Pan-Active Inhibitor Of Anti-Apoptotic Bcl-2 Family Proteins
    184. An Orally Active Anti‐Apoptotic Molecule (Cgp 3466B) Preserves Mitochondria And Enhances Survival In An Animal Model Of Motoneuron Disease
    185. Analysis Of Changes In Pro (Gadd153) And Anti Apoptotic (Grp78) Gene Expression After Ischemic-Reperfusion Injury Of The Small Intestine
    186. Analysis Of Chemotherapy-Induced Cardiotoxicity Suggests A Possible Role Of Suppression Of The Tcl1A/Akt Anti-Apoptotic …
    187. Analysis Of The Anti-Apoptotic Activity Of Four Vaccinia Virus Proteins Demonstrates That B13 Is The Most Potent Inhibitor In Isolation And During Viral Infection
    188. Analysis Of The Anti-Apoptotic Protein Bcl-2 In Oral Squamous Cell Carcinoma
    189. Analysis Of The Anti-Proliferative And The Pro-Apoptotic Efficacy Of Syk Inhibition In Multiple Myeloma
    190. Analysis Of The Genes Encoding The Latency Associated Transcript Of Bovine Herpesvirus Type 1 (Bhv-1) And Herpes Simplex Type 1: Their Anti-Apoptotic Activity And A …
    191. Anaplasma Phagocytophilum Up-Regulates Some Anti-Apoptotic Genes In Neutrophils And Pro-Inflammatory Genes In Mononuclear Cells Of Sheep
    192. And Erufosine Combination Against Castration-Resistant Prostate Cancer: A Promising But Cell-Type Specific Response Associated With The Modulation Of Anti-Apoptotic …
    193. And Functional Implications Of Correlations To Recurrence Status And To Expression Of Matrix Metalloproteinases‐3/9, Retinoic Acid Receptor‐Β, And Anti‐Apoptotic …
    194. And Odq And Protein Kinase G (Pkg) Inhibitor Kt5823 Trigger Apoptotic Dna Fragmentation In Immortalized Uterine Epithelial Cells: Anti‐Apoptotic Effects Of Basal …
    195. And Stem Cellsp60The Pparbeta Agonist Gw0742 Protects Cardiac Myocytes From Oxidative Stress Through Anti-Oxidant, Anti-Inflammatory And Anti-Apoptotic …
    196. And Validation Of Mitochondria-Based Functional Assay As A Useful Tool To Identify Bh3-Like Molecules Selectively Targeting Anti-Apoptotic Bcl-2 Proteins
    197. Androgenic Regulation Of The Anti-Apoptotic Bcl-2 Family Member Mcl-1 In Prostate Cancer Cells.
    198. Angelica Sinensis Exerts Angiogenic And Anti-Apoptotic Effects Against Cerebral Ischemia–Reperfusion Injury By Activating P38Mapk/Hif-1/Vegf-A Signaling In …
    199. Animal Anti-Apoptotic Genes Ameliorate The Loss Of Turgor In Water-Stressed Transgenic Tobacco
    200. Animal Anti–Apoptotic Genes Enhance Recovery From Drought Stress In Tobacco
    201. Annexin V Assay-Proven Anti-Apoptotic Effect Ofascorbic Acid 2-Glucoside After Cold Ischemia/Reperfusion Injury In Rat Liver Transplantation
    202. Antagonism Between Apoptotic (Bax/Bcl‐2) And Anti‐Apoptotic (Iap) Signals In Human Osteoblastic Cells Under Vector‐Averaged Gravity Condition
    203. Antagonism Of Etoposide Cytotoxicity For Neuroblastoma By Retinoic Acid Is Mediated By The Anti-Apoptotic Bcl-2 Family Proteins.
    204. Antagonistic Efficacy Of Luteolin Against Lead Acetate Exposure-Associated With Hepatotoxicity Is Mediated Via Antioxidant, Anti-Inflammatory, And Anti-Apoptotic …
    205. Antagonists Against Anti-Apoptotic Bcl-2 Family Proteins For Cancer Treatment.
    206. Antagonists Of Bombesin/Gastrin-Releasing Peptide Decrease The Expression Of Angiogenic And Anti-Apoptotic Factors In Human Glioblastoma
    207. Antagonists Of Iap-Family Anti-Apoptotic Proteins-Probe 1
    208. Antagonists Of Iap-Family Anti-Apoptotic Proteins-Probe 2
    209. Anthocyanin-Rich Extracts From Black Raspberries Inhibit Growth Promoting And Anti-Apoptotic Signaling pathways In Human Bladder Carcinoma Cell Lines
    210. Anti Apoptotic Effect Of Qidan Tongmai Tablet In Myocardium Ischemia-Reperfusion Injury Mediated By Pi3K/Akt Signaling Pathway [J]
    211. Anti Apoptotic Role Of Ccr9 In Prostate Cancer
    212. Anti Diabetic Activity Of Seed Of Eugenia Jambolana In Streptozotocin Induced Diabetic Male Albino Rat: An Apoptotic And Genomic Approach
    213. Anti-/Pro-Apoptotic Effects Of Hesperetin Against 7, 12-Dimetylbenz (A) Anthracene-Induced Alteration In Animals
    214. Anti-Alopecia Agent Using Super Anti-Apoptotic Protein Fnk
    215. Anti-Amyloidogenic And Anti-Apoptotic Effect Of Α-Bisabolol Against Aβ Induced Neurotoxicity In Pc12 Cells
    216. Anti-Amyloidogenic And Anti-Apoptotic Role Of Melatonin In Alzheimer Disease
    217. Anti-Amyloidogenic, Anti-Oxidant And Anti-Apoptotic Role Of Gelsolin In Alzheimer’S Disease
    218. Anti-And Pro-Apoptotic Bcl2 Proteins Distribution And Metabolic Profile In Human Coronary Aorta Endothelial Cells Before And After Hyppdt
    219. Anti-Androgen Receptor Activity Of Apoptotic Ck2 Inhibitor Cx4945 In Human Prostate Cancer Lncap Cells
    220. Anti-Angiogenic And Pro-Apoptotic Effects Of A Small-Molecule Jfd-Ws In In Vitro And Breast Cancer Xenograft Mouse Models
    221. Anti-Apoptotic A1 Is Not Essential For Lymphoma Development In Eµ-Myc Mice But Helps Sustain Transplanted Eµ-Myc Tumour Cells
    222. Anti-Apoptotic Action By Hypoxia Inducible Factor 1-Alpha In Human Pituitary Adenoma Cell Line, Hp-75 In Hypoxic Condition
    223. Anti-Apoptotic Action Of (2S, 3S, 4R)-N ″-Cyano-N-(6-Amino-3, 4-Dihydro-3-Hydroxy-2-Methyl-2-Dimethoxymethyl-2H-Benzopyran-4-Yl)-N′-Benzylguanidine (Kr …
    224. Anti-Apoptotic Action Of Anti-Alzheimer Drug, Tv3326 [(N-Propargyl)-(3R)-Aminoindan-5-Yl]-Ethyl Methyl Carbamate, A Novel Cholinesterase-Monoamine Oxidase …
    225. Anti-Apoptotic Action Of Api2-Malt1 Fusion Protein Involved In T (11; 18)(Q21; Q21) Malt Lymphoma
    226. Anti-Apoptotic Action Of Exendin-4 In Ins-1 Beta Cells: Comparative Protein Pattern Analysis Of Isolated Mitochondria
    227. Anti-Apoptotic Action Of Hepatocyte Growth Factor Through Mitogen-Activated Protein Kinase On Human Aortic Endothelial Cells
    228. Anti-Apoptotic Action Of Hydrogen Sulfide Is Associated With Early Jnk Inhibition
    229. Anti-Apoptotic Action Of Insulin-Like Growth Factor-I During Human Preimplantation Embryo Development
    230. Anti-Apoptotic Action Of Macrophage Stimulating Protein (Msp)
    231. Anti-Apoptotic Action Of Nerve Growth Factor In Mouse Osteoblastic Cell Line
    232. Anti-Apoptotic Action Of Polyphenols Derived From Red Wine And Green Tea Against Beta-Amyloid In Hippocampal Cells
    233. Anti‐Apoptotic Action Of Stem Cell Factor On Oocytes In Primordial Follicles And Its Signal Transduction
    234. Anti-Apoptotic Action Of Wnt5A In Dermal Fibroblasts Is Mediated By The Pka Signaling Pathways
    235. Anti-Apoptotic Action Of Zearalenone In Mcf-7 Cells
    236. Anti-Apoptotic Actions Of Insulin-Like Growth Factors: Lessons From Development And Implications In Neoplastic Cell Transformation
    237. Anti-Apoptotic Actions Of Intranasal Insulin-Like Growth Factor Ⅰ And Erythropoietin In Rats With Epilepsy [J]
    238. Anti-Apoptotic Actions Of Ppar-Γ Against Ischemic Stroke
    239. Anti-Apoptotic Actions Of R-2Hmp In Cerebeuar Granule Celis: Changes Of Mitochondrial Membrane Potential And Sub-Cellular Gapdh Protein
    240. Anti-Apoptotic Actions Of The Platelet-Activating Factor Acetylhydrolase I Α2 Catalytic Subunit
    241. Anti-Apoptotic Actions Of Vasopressin In H32 Neurons Involve Map Kinase Transactivation And Bad Phosphorylation
    242. Anti-Apoptotic Activities Of Gage-7C, A Gene Expressed In Multiple Tumors
    243. Anti-Apoptotic Activity And Proteasome-Mediated Degradation Of Xenopus Mcl-1 Protein In Egg Extracts
    244. Anti-Apoptotic Activity In Deep Pelvic Endometriosis
    245. Anti-Apoptotic Activity Of Anthocyanins Has Potential To Inhibit Caspase-3 Signaling
    246. Anti‐Apoptotic Activity Of Bak Foong Pills And Its Ingredients On 6‐Hydroxydopamine‐Induced Neurotoxicity In Pc12 Cells
    247. Anti‐Apoptotic Activity Of Bcl‐2 Is Enhanced By Its Interaction With Rtn3
    248. Anti-Apoptotic Activity Of Caffeic Acid, Ellagic Acid And Ferulic Acid In Normal Human Peripheral Blood Mononuclear Cells: A Bcl-2 Independent Mechanism
    249. Anti-Apoptotic Activity Of Et B Receptor Agonist, Irl-1620, Protects Neural Cells In Rats With Cerebral Ischemia
    250. Anti-Apoptotic Activity Of Gentiopicroside In D-Galactosamine/Lipopolysaccharide-Induced Murine Fulminant Hepatic Failure
    251. Anti-Apoptotic Activity Of Ginsenoside Rb1 In Hydrogen Peroxide-Treated Chondrocytes: Stabilization Of Mitochondria And The Inhibition Of Caspase-3
    252. Anti-Apoptotic Activity Of Hemagglutinin-33 And Botulinum Neurotoxin And Its Implications To Therapeutic And Countermeasure Issues
    253. Anti-Apoptotic Activity Of Human Matrix Metalloproteinase-2 Attenuates Diabetes Mellitus
    254. Anti-Apoptotic Activity Of Hydroxytyrosol And Hydroxytyrosyl Laurate
    255. Anti-Apoptotic Activity Of Hydroxytyrosol And Hydroxytyrosyl Laurate. Food Chem. Toxicol.
    256. Anti-Apoptotic Activity Of Japanese Encephalitis Virus Ns5 Protein In Human Medulloblastoma Cells Treated With Interferon-Β
    257. Anti-Apoptotic Activity Of Laminarin Polysaccharides And Their Enzymatically Hydrolyzed Oligosaccharides From Laminaria Japonica
    258. Anti‐Apoptotic Activity Of Porcine Cflip In Ovarian Granulosa Cell Lines
    259. Anti-Apoptotic Activity Of The Glutathione Peroxidase Homologue Encoded By Hiv-1
    260. Anti-Apoptotic Agents For The Treatment Of Vascular Disease
    261. Anti-Apoptotic And Angiogenic Effects Of Intelectin-1 In Rat Cerebral Ischemia
    262. Anti-Apoptotic And Anti-Glycative Effects Of Asiatic Acid In The Brain Of D-Galactose Treated Mice
    263. Anti-Apoptotic And Anti-Inflammatory Activities Of Edible Fresh Water Algae Prasiola Japonica In Uvb-Irradiated Skin Keratinocytes
    264. Anti-Apoptotic And Anti-Inflammatory Effect Of Piperine On 6-Ohda Induced Parkinson’S Rat Model
    265. Anti-Apoptotic And Anti-Inflammatory Effects Of Hydrogen Sulfide In A Rat Model Of Regional Myocardial I/R
    266. Anti-Apoptotic And Anti-Inflammatory Effects Of Naringin On Cisplatin-Induced Renal Injury In The Rat
    267. Anti-Apoptotic And Anti-Inflammatory Effects Of Olive Leaf Extract Against Cisplatin-Induced Nephrotoxicity In Male Rats
    268. Anti-Apoptotic And Anti-Inflammatory Effects Of Silybum Marianum In Treatment Of Experimental Steatohepatitis
    269. Anti-Apoptotic And Antioxidant Defenses In The Freeze Tolerant Wood Frog, Rana Sylvatica
    270. Anti-Apoptotic And Antioxidant Effect Of Cerium Oxide Nanoparticles On Cyclophosphamide-Induced Hepatotoxicity.
    271. Anti-Apoptotic And Antioxidant Effect Of Leptin On Ccl4-Induced Acute Liver Injury In Rats
    272. Anti-Apoptotic And Anti-Oxidant Effects Of Caffeic Acid Phenethyl Ester On Cadmium-Induced Testicular Toxicity In Rats
    273. Anti‐Apoptotic And Anti‐Oxidant Effects Of Grape Seed Proanthocyanidin Extract In Preventing Cyclosporine A‐Induced Nephropathy
    274. Anti-Apoptotic And Antioxidant Effects Of Low Dose Gamma Irradiation Against Diabetes-Induced Brain Injury In Rats
    275. Anti-Apoptotic And Anti-Oxidant Proteins In Glioblastomas: Immunohistochemical Expression Of Beclin And Dj-1 And Its Correlation With Prognosis
    276. Anti-Apoptotic And Anti-Oxidative Mechanisms Of Minocycline Against Sphingomyelinase/Ceramide Neurotoxicity: Implication In Alzheimer’S Disease And Cerebral …
    277. Anti-Apoptotic And Anti-Oxidative Roles Of Quercetin After Traumatic Brain Injury
    278. Anti-Apoptotic And Antiproliferative Effect Of Bcl-2 Gene Transferred To E1A+ Cha-Ras-Transformed Cells
    279. Anti-Apoptotic And Anti-Senescence Effects Of Klotho On Vascular Endothelial Cells
    280. Anti-Apoptotic And Apoptotic Action Of (2)-Deprenyl And Its Metabolites
    281. Anti-Apoptotic And Apoptotic Effects Of Xrel3 In Human Cervical Cancer Cells
    282. Anti-Apoptotic And Apoptotic Pathway Analysis Of Arsenic Trioxide‑Induced Apoptosis In Human Gastric Cancer Sgc-7901 Cells
    283. Anti-Apoptotic And Beneficial Metabolic Activities Of Resveratrol In Type Ii Gaucher Disease
    284. Anti-Apoptotic And Cardioprotective Effects Of A Novel Cell-Permeable Peptide In The Isolated Rat Heart
    285. Anti-Apoptotic And Cytoprotective Effect Of Enicostemma Littorale Against Oxidative Stress In Islets Of Langerhans
    286. Anti-Apoptotic And Growth-Promoting Markers In Adult Medulloblastomas.
    287. Anti-Apoptotic And Growth-Stimulatory Functions Of Ck1 Delta And Epsilon In Ductal Adenocarcinoma Of The Pancreas Are Inhibited By Ic261 In Vitro And In Vivo
    288. Anti-Apoptotic And Hepatoprotective Effects Of Gomisin A On Fulminant Hepatic Failure Induced By D-Galactosamine And Lipopolysaccharide In Mice
    289. Anti-Apoptotic And Moderate Anti-Inflammatory Effects Of Berberine In Sulfur Mustard Exposed Keratinocytes
    290. Anti-Apoptotic And Myocardial Protective Effects Of Ethyl Pyruvate After Regional Ischaemia/Reperfusion Myocardial Damage In An In Vivo Rat Model
    291. Anti-Apoptotic And Neuroprotective Effects Of Alpha-Lipoic Acid On Spinal Cord Ischemia–Reperfusion Injury In Rabbits
    292. Anti-Apoptotic And Neuroprotective Effects Of Edaravone Following Transient Focal Ischemia In Rats
    293. Anti-Apoptotic And Neuroprotective Effects Of Edaravone On Neurological Tissue After Acute Spinal Cord Injury In Rats
    294. Anti-Apoptotic And Neuroprotective Effects Of Oxysophoridine On Cerebral Ischemia Both In Vivo And In Vitro
    295. Anti-Apoptotic And Neuroprotective Effects Of Tetramethylpyrazine Following Spinal Cord Ischemia In Rabbits
    296. Anti-Apoptotic And Neuroprotective Effects Of Tetramethylpyrazine Following Subarachnoid Hemorrhage In Rats
    297. Anti-Apoptotic And Neuroprotective Effects Of The Antioxidant Edaravone In Rats Subjected To Cerebral Ischemia-Reperfusion Injury [J]
    298. Anti-Apoptotic And Neuroregenerative Effects Of Soluble Protein Fraction Of The Epidermal Secretion From The Arabian Gulf Catfish Following Sciatic Nerve Crush Injury …
    299. Anti-Apoptotic And Oncogenic Function Of Hsp27
    300. Anti-Apoptotic And Oncogenic Properties Of The Dsrna-Binding Protein Of Vaccinia Virus, E3L
    301. Anti-Apoptotic And Ontogenetic Effects Of The Pituitary Adenylate Cyclase-Activating Peptide In The Postnatal Rat Retina
    302. Anti-Apoptotic And Pro-Apoptotic Effect Of Nepp11 On Manganese-Induced Apoptosis And Jnk Pathway Activation In Pc12 Cells
    303. Anti-Apoptotic And Pro-Apoptotic Gene Expression Evaluated From Eutopic Endometrium In The Proliferative Phase Of The Menstrual Cycle Among Women With …
    304. Anti-Apoptotic And Pro-Apoptotic Molecular And Cellular pathways Induced By Viral Agents Of Human And Animal Gastroenteritis: A Comprehensive Review
    305. Anti-Apoptotic And Pro-Apoptotic Roles Of Nf-Κb In Cancer [J]
    306. Anti-Apoptotic And Pro-Inflammatory Signaling In Cancer Cells: Status And Modulation By Chemotherapeutic Drugs
    307. Anti-Apoptotic And Pro-Survival Effect Of Alpinate Oxyphyllae Fructus (Aof) In A D-Galactose-Induced Aging Heart
    308. Anti-Apoptotic And Pro-Survival Effect Of Protocatechuic Acid On Hypertensive Hearts
    309. Anti-Apoptotic And Pro-Survival Effects Of Exercise Training On Hypertensive Hearts
    310. Anti-Apoptotic And Pro-Survival Effects Of Food Restriction On High-Fat Diet-Induced Obese Hearts
    311. Anti-Apoptotic And Protective Effects Of Balsamic Vinegar On The Liver Tissue And Lipid Profiles In Rats Under High-Fat Diet
    312. Anti-Apoptotic Arc Protein Confers Chemoresistance By Controlling Leukemia-Microenvironment Interactions Through A Nfκb/Il1Β Signaling Network
    313. Anti-Apoptotic Bag3 Gene In Tako-Tsubo Cardiomyopathy
    314. Anti-Apoptotic Bcl2 And Bcl-Xl Proteins Involved In Stroma-Induced Drug Tolerance To Hsp70 And Hsp90 Inhibitors In Leukemia And B-Cell Lymphoma
    315. Anti‐Apoptotic Bcl‐2 Enhancing Requires Fgf‐2/Fgf Receptor 1 Binding In Mouse Osteoblasts
    316. Anti-Apoptotic Bcl-2 Fails To Form Efficient Complexes With Pro-Apoptotic Bak To Protect From Celecoxib-Induced Apoptosis
    317. Anti-Apoptotic Bcl-2 Family Member Mcl-1 Regulates Cell Viability And Bone-Resorbing Activity Of Osteoclasts
    318. Anti-Apoptotic Bcl-2 Family Members Confer Resistance To Calicheamicin-Based Antibody-Drug Conjugate Therapy Of Acute Leukemia
    319. Anti-Apoptotic Bcl-2 Family Members In Development
    320. Anti-Apoptotic Bcl-2 Family Proteins Disassemble Ceramide Channels
    321. Anti-Apoptotic Bcl-2 Family Proteins In Acute Neural Injury
    322. Anti-Apoptotic Bcl-2 Gene Modified Rat Mscs Improves Heart Function After Myocardial Infarction
    323. Anti-Apoptotic Bcl-2 Gene Transfection Of Human Articular Chondrocytes Protects Against Nitric Oxide-Induced Apoptosis
    324. Anti-Apoptotic Bcl-2 Mrna Expression And Long-Term Corneal Endothelial Cell Survival Against Oxidative Stress Ex Vivo: Effect Of Vip
    325. Anti-Apoptotic Bcl-2 Proteins Govern Cellular Outcome Following B-Raf V600E Inhibition And Can Be Targeted To Reduce Resistance
    326. Anti-Apoptotic Bcl-2 Proteins Via Their Bh4 Domain Are Novel Associated Proteins And Inhibitors Of Ryanodine Receptors
    327. Anti-Apoptotic Bcl-2 Proteins: Structure, Function And Relevance For Radiation Biology
    328. Anti-Apoptotic Bcl-2 Uses Not Only The Bh1-3 Groove But Also The Bh4 Region To Bind And Inhibit Pro-Apoptotic Bax Oligomerization
    329. Anti-Apoptotic Bcl2L2 Increases Megakaryocyte Proplatelet Formation In Cultures Of Human Cord Blood
    330. Anti-Apoptotic Bcl-X L But Not Mcl-1 Contributes To Protection Against Virus-Induced Apoptosis
    331. Anti‐Apoptotic Bcl‐Xl Protein In Complex With Bh3 Peptides Of Pro‐Apoptotic Bak, Bad, And Bim Proteins: Comparative Molecular Dynamics Simulations
    332. Anti-Apoptotic Benzodiazepine Receptor Ligand Inhibitors
    333. Anti-Apoptotic Bfl-1 Is The Major Effector In Activation-Induced Human Mast Cell Survival
    334. Anti-Apoptotic Bioactive Coatings Including Chondroitin Sulphate And Epidermal Growth Factor
    335. Anti‐Apoptotic Brain And Reproductive Organ‐Expressed Proteins Enhance Cisplatin Resistance In Lung Cancer Cells Via The Protein Kinase B Signaling Pathway
    336. Anti-Apoptotic But Not Mitotic Effects Of 3, 3′, 5-Triiodo-L-Thyronine In The Liver Of Brain Dead Rats
    337. Anti-Apoptotic Cardioprotective Effects Of Shp-1 Gene Silencing Against Ischemia–Reperfusion Injury: Use Of Deoxycholic Acid-Modified Low Molecular Weight …
    338. Anti‐Apoptotic Defense Of Bcl‐2 Gene Against Hydroperoxide‐Induced Cytotoxicity Together With Suppressed Lipid Peroxidation, Enhanced Ascorbate Uptake, And …
    339. Anti-Apoptotic Effect And The Mechanism Of Orientin On Ischaemic/Reperfused Myocardium
    340. Anti-Apoptotic Effect By The Suppression Of Irf1 As A Downstream Of Wnt/Β-Catenin Signaling In Colorectal Cancer Cells
    341. Anti-Apoptotic Effect Of 3-Aminobenzamide, An Inhibitor Of Poly (Adp-Ribose) Polymerase, Against Multiple Organ Damage Induced By Gamma Irradiation In Rats
    342. Anti-Apoptotic Effect Of Acetyl-L-Carnitine And L-Carnitine In Primary Cultured Neurons
    343. Anti-Apoptotic Effect Of Activated Protein C On Lipopolysaccharide-Stimulated Human Umbilical Vein Endothelial Cells Is Associated With The Inhibition Of The Caspase-3 …
    344. Anti-Apoptotic Effect Of Astragalus Polysaccharide On Myeloid Cells
    345. Anti-Apoptotic Effect Of Atorvastatin In Experimental Nephropathy Induced By Isoproterenol In Rats
    346. Anti‐Apoptotic Effect Of Atorvastatin, A 3‐Hydroxy‐3‐Methylglutaryl Coenzyme A Reductase Inhibitor, On Cardiac Myocytes Through Protein Kinase C Activation
    347. Anti-Apoptotic Effect Of Banhasasim-Tang On Chronic Acid Reflux Esophagitis
    348. Anti‐Apoptotic Effect Of Benidipine, A Long‐Lasting Vasodilating Calcium Antagonist, In Ischaemic/Reperfused Myocardial Cells
    349. Anti-Apoptotic Effect Of Bivalirudin In Rat Islets Isolation
    350. Anti-Apoptotic Effect Of Caspase Inhibitors On H2O2-Treated Hela Cells Through Early Suppression Of Its Oxidative Stress
    351. Anti-Apoptotic Effect Of Cgmp In Cultured Astrocytes Inhibition By Cgmp-Dependent Protein Kinase Of Mitochondrial Permeable Transition Pore
    352. Anti-Apoptotic Effect Of Claudin-1 In Tamoxifen-Treated Human Breast Cancer Mcf-7 Cells
    353. Anti-Apoptotic Effect Of Claudin-1 On Tnf-Α-Induced Apoptosis In Human Breast Cancer Mcf-7 Cells
    354. Anti-Apoptotic Effect Of Clusterin On Cisplatin-Induced Cell Death Of Retinoblastoma Cells
    355. Anti-Apoptotic Effect Of Combined Melatonin And Exercise Following Focal Cerebral Ischemic In Rats
    356. Anti-Apoptotic Effect Of Dexamethasone In An Ototoxicity Model
    357. Anti-Apoptotic Effect Of Esculin On Dopamine-Induced Cytotoxicity In The Human Neuroblastoma Sh-Sy5Y Cell Line
    358. Anti-Apoptotic Effect Of Ethanol Extract Of Bojungbangamtang On Cisplatin-Induced Apoptosis In Rat Mesangial Cells
    359. Anti-Apoptotic Effect Of Exercise On Neuropsychiatric Disorders
    360. Anti-Apoptotic Effect Of Fermented Citrus Sunki Peel Extract On Chemical Hypoxia-Induced Neuronal Injury
    361. Anti-Apoptotic Effect Of Ferulic Acid Through Modification Of Sirt1, Sirt7 And Caspase 6 Gene Expression
    362. Anti-Apoptotic Effect Of Ginsenoside Rg1 On Neuron After Neonatal Hypoxia Ischemia Brain Damage
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