• SHOP
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      • 2-DEOXY-D-GLUCOSE (2DG)
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      • AMERICAN GINSENG
      • AMYGDALIN
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      • ANGELICA ARCHANGELICA
      • ANGELICA SINENSIS
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      • ISOVITEXIN
      • JACEOSIDIN
      • KAEMPFEROL
      • KIGELIA AFRICANA
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      • LEMON BALM
      • LICORICIDIN
      • LIPOIC ACID
      • LUPEOL
      • MAGNOLOL
      • MENAQUINONE 4
      • MULBERRY LEAF
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    • ABOUT
    • SCIENTIFIC STUDIES
      • ADAPTOGENS
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      • ADDICTION & THE BRAIN
      • ADDICTION & STRESS
      • ADDICTION WITHDRAWAL
      • ADIPOCYTE DEDIFFERENTIATION (THE REVERSAL OF FAT FORMATION)
      • ADIPOCYTE DIFFERENTIATION
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      • ALZHEIMER’S, DEMENTIA, PARKINSON’S
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      • AMPK
      • ANTI AGING
      • ANTIAGING EFFECTS OF COFFEE
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      • ANTI GLYCATIVE
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      • ANTI WRINKLE AGENTS
      • ANXIOLYTIC
      • APOPTOSIS
      • APOPTOSIS IN 3T3-L1
      • AUTOPHAGY
      • BCL-2
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      • BDNF
      • BECLIN-1 & AUTOPHAGY
      • BH3 MIMETICS
      • BIM aka BCL2L11
      • BIOMIMETIC HYDROXYAPATITE
      • BMI-1
      • BPA & OBESITY
      • BRASSINOSTEROIDS
      • CALORIE RESTRICTION
      • CALORIE RESTRICTION & LIFESPAN EXTENSION
      • CARBAMYLATION
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      • CARBONYL STRESS
      • CARDIOPROTECTIVE AGENTS
      • CARDIAC GLYCOSIDES
      • CATALASE
      • CELL CYCLE ARREST
      • CENTENARIANS
      • CDK5
      • CHOLESTEROL EFFLUX
      • COGNITIVE ENHANCEMENT
      • COLD SHOCK PROTEINS
      • COLD-INDUCIBLE RNA-BINDING PROTEIN (CIRBP) & DNA REPAIR
      • CONDITIONED PLACE PREFERENCE
      • CORTICOTROPIN RELEASING FACTOR
      • CRYOTHERAPY
      • CRYOLIPOLYSIS: FREEZING FAT TO DEATH
      • CYP2E1
      • CYTOKINES IN PAIN, INFLAMMATION & AGING
      • DAF-16
      • DEPERSONALIZATION
      • DIABETES & CANCER
      • DIHYDROTESTOSTERONE (DHT)
      • DNA METHYLATION & AGING
      • DNA REPAIR
      • DNA REPAIR VIA FLAVONOIDS & POLYPHENOLS
      • DRY FASTING AND FLUID RESTRICTION FASTING
      • DYNORPHIN
      • ELLAGITANNINS
      • ENDOCRINE DISRUPTING CHEMICALS
      • ENLARGED HEART AND CARDIOMEGALY
      • EPIGENETIC MODIFIERS
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      • ERGOGENIC AGENTS (INCREASE ATHLETIC PERFORMANCE)
      • EXCITOXICITY & THE BRAIN
      • EXTRACELLULAR MATRIX STIFFENING (10TH HALLMARK OF AGING)
      • EXTENDS LIFESPAN
      • EXTINCTION TRAINING
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      • FASTING MIMICKING DIET
      • FEAR EXTINCTION
      • FGF21
      • FLAVONES
      • GABA (γ-AMINOBUTYRIC ACID)
      • GALLOTANNINS
      • GLUCONEOGENESIS
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      • GLUTAMATE & BRAIN
      • GLYCATION
      • GUT BRAIN AXIS
      • KLOTHO
      • K OPIOD RECEPTOR & ADDICTION
      • FASTING, CALORIE RESTRICTION & EXTENDING LIFESPAN
      • FOXO3
      • FOXO4
      • HALLMARKS OF AGING
      • HAIR REPIGMENTATION
      • HEPATOPROTECTIVE AGENTS (KEEPING LIVER HEALTHY)
      • HMGB1
      • HORMESIS
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      • HSP70, THE ANTI-AGING PROTEIN
      • HSP90 INHIBITORS
      • HYPERGLYCEMIA
      • HYPERALGESIA
      • HYPERINSULINEMIA
      • HYPOTHALAMIC PITUITARY ADRENAL HPA AXIS
      • HYPOACTIVE SEXUAL DESIRE (WHY PEOPLE HAVE ZERO SEX DRIVE)
      • HYPOCRETIN OREXIN
      • IKK
      • IL-6/STAT3
      • IRISIN
      • ISOFLAVONES
      • IMMUNOSENESCENCE
      • INCREASE PROTEIN SYNTHESIS
      • INFECTOBESITY
      • INFLAMMATION & ANXIETY
      • INFLAMMATION & CANCER
      • INFLAMMATION & DEPRESSION
      • INFLAMMATION & OBESITY
      • INFLAMMAGING
      • INHIBITION OF RENAL GLUCOSE REABSORPTION
      • INSULIN & AGING
      • INSULIN & CANCER: HOW INSULIN LITERALLY PROTECTS CANCER CELLS FROM BEING KILLED
      • INSULIN & MTOR
      • INSULIN & OBESITY
      • INSULIN OXIDATIVE STRESS
      • INTERMITTENT FASTING
      • JAK INHIBITION ALLEVIATES SASP
      • JNK ACTIVATION PREVENTS PREMATURE SENESCENCE
      • KETONE BODIES
      • KETOGENIC DIET
      • LEYDIG CELL STEROIDOGENESIS
      • LIFESPAN EXTENSION
      • LIPOLYTIC AGENTS
      • LIPID DROPLETS
      • LIPOLYSIS (THE DECOMPOSITION OF BODY FAT)
      • LOWERING CHOLESTEROL THRU FASTING, DIET & MEDICINAL PLANTS
      • MATRIX METALLOPROTEINASES (MMPs)
      • MCL-1
      • MDM2 INHIBITION AS SASP INHIBITOR
      • MEDITERRANEAN DIET
      • METABOLIC REPROGRAMMING
      • METABOLIC SYNDROME
      • METHIONINE RESTRICTION
      • MITOCHONDRIAL UNCOUPLING
      • MONKEYPOX
      • MSG (MONOSOSODIUM GLUTAMATE)
      • MUSCLE FORCE PRODUCTION
      • MUSCLE ATROPHY (PREVENTING)
      • MYOGENESIS
      • MYOSTATIN INHIBITION
      • MYOSTATIN INHIBITION PRESERVES MUSCLE
      • mTORC2
      • mTOR: THE RAPID AGING PATHWAY
      • NATURAL ANTICOAGULANTS
      • NATURAL AROMATASE INHIBITORS
      • NEUROGENESIS (GROWING NEW BRAIN CELLS)
      • NEUROCHEMISTRY OF ADDICTION
      • NEUROPLASTICITY
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      • NEUTRALIZING OXIDATIVE STRESS WITH MEDICINAL PLANTS
      • NMDA & ANXIETY & DEPRESSION
      • NMDA RECEPTOR & FEAR
      • NON OPIOD ANALGESICS
      • NOOTROPICS
      • NORADRENERGIC
      • NOREPINEPHRINE
      • NRF2: MASTER REGULATOR OF THE AGING PROCESS
      • NF-KB
      • OBESOGENS
      • ONCOGENE ACTIVATION INDUCED SENESCENCE
      • OVERNUTRITION
      • OXIDATIVE STRESS & AGING
      • P16INK4A
      • P38MAPK
      • P53: TUMOR SUPRESSOR
      • PERIODONTITIS
      • PHYTOCHEMICALS
      • PHYTOSTEROLS
      • PHYTOSTANOLS
      • PHYTOECDYSTEROIDS
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      • PROTEIN CARBONYLATION
      • POLYAMINES & THEIR EFFECT ON BRAIN (NMDA, DEPRESSION, SUICIDE RISK)
      • POLYPHENOLS AS COVID-19 TREATMENT & PREVENTION
      • PPARY2
      • PREMATURE SENESCENCE
      • PREVENTING SKIN AGING
      • PUFAS
      • PURGATIVES
      • RAPAMYCIN (MTOR INHIBITION)
      • RED WINE
      • RENAL (KIDNEY) PROTECTIVE AGENTS
      • REMINERALIZATION OF TEETH
      • REPAIR OF DNA BREAKS “DOUBLE STRAND”
      • RESTORE INSULIN SENSITIVITY
      • SASP & ADIPOSE TISSUE
      • SEX HORMONE BINDING GLOBULIN
      • SENESCENT CELLS, SASP & SENOLYTICS
      • SENESCENCE-BETA-GALACTOSIDASE (SA-β-gal or SABG)
      • SGLT2 INHIBITORS
      • SGLT2 INHIBITION FOR LIFESPAN EXTENSION
      • SHBG
      • SIRT1
      • SKELETAL MUSCLE HYPERTROPHY (THE SCIENCE OF BUILDING MUSCLE)
      • SKIN ELASTICITY
      • SKIN PHOTOAGING (Preventing & Repairing)
      • SLEEP DEPRIVATION AS THERAPY FOR DEPRESSION
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      • STEM CELL EXHAUSTION
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    FOXO4
    February 10, 2020
    SUGAR & AGING
    February 10, 2020
    1. A glaucolide-type sesquiterpene lactone from Vernonia galamensis ssp. nairobensis
    2. A review of plant species assessedin vitro for antiamoebic activity or both antiamoebic and antiplasmodial properties
    3. A study on the involvement of TLR4/STAT3 signaling in the antimelanoma effects of atractylenolide II/Fu Xiuqiong.
    4. Allergic contact dermatitis from sesquiterpenoids of the Compositae family of plants
    5. Annexin A2 upregulation protects human retinal endothelial cells from oxygen‑glucose deprivation injury by activating autophagy
    6. Antibacterial constituents of the Nepalese medicinal herb, Centipeda minima
    7. Antimalarial activity of plant metabolites
    8. Antiparasitic activity in Asteraceae with special attention to ethnobotanical use by the tribes of Odisha, India
    9. Antiproliferative effects of short-chain fatty acids on human colorectal cancer cells via gene expression inhibition
    10. Antiprotozoal activities of Centipeda minima
    11. Anti-Protozoal Potential of Heterocyclic Compounds Against Giardiasis
    12. Antiviral Activity of the Sesquiterpene Lactones from Centipeda minima against Influenza a Virus in vitro
    13. Arnicolide D, from the herb Centipeda minima, Is a Therapeutic Candidate against Nasopharyngeal Carcinoma
    14. Baicalein, as a Prooxidant, Triggers Mitochondrial Apoptosis in MCF-7 Human Breast Cancer Cells Through Mobilization of Intracellular Copper and Reactive …
    15. Biomarker development for hepatocellular carcinoma early detection: current and future perspectives
    16. Bioprospecting for drug research and functional foods for the prevention of diseases—Role of flavonoids in drug development
    17. Brevilin A induces apoptosis and autophagy of colon adenocarcinoma cell CT26 via mitochondrial pathway and PI3K/AKT/mTOR inactivation
    18. Brevilin A Induces Cell Cycle Arrest and Apoptosis in Nasopharyngeal Carcinoma
    19. Brevilin A promotes oxidative stress and induces mitochondrial apoptosis in U87 glioblastoma cells
    20. Brevilin A , a novel natural product, inhibits janus kinase activity and blocks STAT3 signaling in cancer cells
    21. Brevilin A , a Sesquiterpene Lactone, Inhibits the Replication of Influenza A Virus In Vitro and In Vivo
    22. Bulbine frutescens Phytochemicals as a Promising Anti-cancer Drug Discovery Source: A Computational Study
    23. Centipeda minima extract exerts antineuroinflammatory effects via the inhibition of NF-κB signaling pathway
    24. Chemical constituents from Centipeda minima
    25. Constituents of Helenium Species. VII. Bitter Principles of H. pinnatifidum (Nutt.) Rydb., H vernale Walt., H. brevifolium (Nutt.) A. Wood and H. flexuosum Raf.1
    26. Constituents of Helenium species. XXI. Sesquiterpene lactones of Helenium alternifolium. Structures of Brevilin A , linifolin A, and alternilin
    27. Cryptotanshinone, a Stat3 inhibitor, suppresses colorectal cancer proliferation and growth in vitro
    28. Dehydrocrenatidine is a novel janus kinase inhibitor
    29. Detarium microcarpum Stem Bark Extracts Induce Apoptosis in Human Breast Adenocarcinoma MDA MB 231 Cells via cJNK Activation and Mitochondrial Cytochrome …
    30. Discovery and evaluation of Atopaxar hydrobromide, a novel JAK1 and JAK2 inhibitor, selectively induces apoptosis of cancer cells with constitutively activated STAT3
    31. EGFL7 promotes hepatocellular carcinoma cell proliferation and inhibits cell apoptosis through increasing CKS2 expression by activating Wnt/β‐catenin signaling
    32. Exploring QSAR of antiamoebic agents of isolated natural products by MLR, ANN, and RTO
    33. Functions and Implications of Autophagy in Colon Cancer
    34. Handbook of compounds with antiprotozoal activity isolated from plants
    35. Hecogenin acetate inhibits reactive oxygen species production and induces cell cycle arrest and senescence in the A549 human lung cancer cell line
    36. Helenanolides, guaianolide glucosides and other constituents of two Helenium donianum varieties
    37. Hepatocellular carcinoma confirmation, treatment, and survival in surveillance, epidemiology, and end results registries, 1992‐2008
    38. High-Throughput Drug Screening Based on Cancer Signaling in Natural Product Screening
    39. Historical Development of STAT3 Inhibitors and Early Results in Clinical Trials
    40. Human antimicrobial peptides as therapeutics for viral infections
    41. Immune Modulation of Asian Folk Herbal Medicines and Related Chemical Components for Cancer Management
    42. Improved procedure for the Reformatsky reaction of aliphatic aldehydes and ethyl bromoacetate
    43. In vitro evaluation of anti-hepatoma activity of Brevilin A : involvement of Stat3/Snail and Wnt/β-catenin pathways
    44. Inhibitor of signal transducer and activator of transcription 3 (STAT3) suppresses ovarian cancer growth, migration and invasion and enhances the effect of …
    45. Insights into Thymus Development and Viral Thymic Infections
    46. Kinase inhibitors as potential agents in the treatment of multiple myeloma
    47. Marine natural products: Biodiscovery, biodiversity, and bioproduction
    48. Mechanisms of photochemical reactions in solution. LIII. Cycloaddition of carbonyl compounds to allenes
    49. Medicinal plants of Nepal: ethnomedicine, pharmacology, and phytochemistry
    50. N6-substituted adenosine analogues, a novel class of JAK2 inhibitors, potently block STAT3 signaling in human cancer cells
    51. Natural products as important tyrosine kinase inhibitors
    52. Natural products as potential antiparasitic drugs
    53. Natural Products as Promising Leads Against Oncogenic Transcription Factors and Associated Signalling Pathways
    54. Natural products targeting STAT3 signaling pathways in cancer cells
    55. Non-canonical programmed cell death mechanisms triggered by natural compounds
    56. NSs Filament Formation Is Important but Not Sufficient for RVFV Virulence In Vivo
    57. Phytochemical Investigation and Ant Arthritic Activity of Centipeda minima and Bauhinia Purpuria
    58. Phytochemical studies and bioactivity of Centipeda and Eremophila species
    59. Pseudoguaianolides in Compositae
    60. Qualitative and quantitative analysis of chemical constituents of Centipeda minima by HPLC-QTOF-MS & HPLC-DAD
    61. Qualitative and quantitative analysis of sesquiterpene lactones in Centipeda minima by UPLC–Orbitrap–MS & UPLC-QQQ-MS
    62. Secondary metabolites and biosynthetic pathway approach in medicinal plant Centipeda minima
    63. Sesquiterpene lactone 6‑O‑angeloylplenolin reverses vincristine resistance by inhibiting YB‑1 nuclear translocation in colon carcinoma cells
    64. Sesquiterpene lactones and flavonoids from Helenium radiatum
    65. Sesquiterpene lactones as taxonomic characters in the Asteraceae
    66. Signal transducers and activators of transcription 3 function in lung cancer
    67. Sinoporphyrin Sodium-Mediated Sonodynamic Therapy Inhibits RIP3 Expression and Induces Apoptosis in the H446 Small Cell Lung Cancer Cell Line
    68. Solvent shift studies on pseudoguaianolides of the helenalin series
    69. STAT3 inhibitors in cancer: a comprehensive update
    70. Structure elucidation of antiplasmodial sesquiterpene lactones from Vernonia Staehelinoides and Oncosiphon piluliferum
    71. Targeting JAK-STAT signal transduction pathways in human carcinomas
    72. Targeting PI3K/AKT/mTOR-mediated autophagy for tumor therapy
    73. Taxonomy of Helenium sect. Actinea (Asteraceae)
    74. The 40 kDa Linear Polyethylenimine Inhibits Porcine Reproductive and Respiratory Syndrome Virus Infection by Blocking Its Attachment to Permissive Cells
    75. The JAK2/STAT3 pathway is involved in the anti-melanoma effects of Brevilin A
    76. The relationship between Janus kinase pathways and microRNAs
    77. Therapeutic modulators of STAT signalling for human diseases
    78. Timosaponin A‑III induces autophagy of T‑cell acute lymphoblastic leukemia Jurkat cells via inhibition of the PI3K/Akt/mTOR pathway
    79. Transcription factor STAT3 as a novel molecular target for cancer prevention
    80. Virtual screening based on ensemble docking targeting wild‐type p53 for anticancer drug discovery
    81. Zelnorm, an agonist of 5-Hydroxytryptamine 4-receptor, acts as a potential antitumor drug by targeting JAK/STAT3 signaling
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