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      Glycitein
      February 19, 2020
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      Isoorientin
      February 19, 2020

      St. John’s Wort is native to Europe and naturalized elsewhere. In 1793 the first specimen in the United States was collected in Pennsylvania. The Greek physicians Galen and Dioscorides recommended it as a diuretic, wound-healing herb, and treatment for menstrual disorders. During the Middle Ages, remarkable, even mystical properties were attributed to it—St. John’s Wort was thought to be best if harvested on St. John’s Day, June 24. Traditionally it was used for wound healing, especially for lacerations involving damaged nerves, and as a diuretic, astringent, and mild sedative. Now used for mild to moderate depression, in clinical trials, patients who took Hypericum extract felt significant improvement in depressive mood indicators such as feelings of sadness, hopelessness, helplessness, and uselessness, as well as fear and difficult or disturbed sleep. St. John's wort extracts may interact with conventional drugs.

      1. A Chiral‐Pool‐Based Approach To The Core Structure Of (+)‐Hyperforin
      2. A Concise Approach Towards The Bicyclo [3.3. 1] Nonan-9-One Core Present In The Phloroglucin Natural Product Hyperforin
      3. A Simple And Reliable Semipreparative High-Performance Liquid Chromatography Technique For The Isolation Of Marker-Grade Hyperforin From Hypericum Perforatum L …
      4. Abstract# 122: Mechanisms Of Hyperforin As An Anti-Angiogenic Angioprevention Agent
      5. Activation Of Nonselective Cation Channels By Hyperforin–A Novel Mechanism Of Antidepressant Activity
      6. Activity Profiles Of Two Hyperforin-Containing Hypericum Extracts In Behavioral Models
      7. Acute And Chronic Actions Of A Dry Methanolic Extract Of Hypericum Perforatum And A Hyperforin-Rich Extract On Dopaminergic And Serotonergic Neurones In Rat Nucleus …
      8. AdHyperforin: A Homologue Of Hyperforin From Hypericum Perforatum
      9. Advances In Studies On Synthesis And Neuropharmacology Of Hyperforin And Its Derivatives
      10. An In Vitro And Hydroponic Growing System For Hypericin, Pseudohypericin, And Hyperforin Production Of St. John’S Wort (Hypericum Perforatum Cv New Stem)
      11. And Biopharmaceutics Stabilization Of Hyperforin Dicyclohexylammonium Salt With Dissolved Albumin And Albumin Nanoparticles For Studying Hyperforin E Ff Ects …
      12. Antibacterial Activity Of Hyperforin From St John’S Wort
      13. Antibacterial Activity Of Hyperforin From St John’S Wort, Against Multiresistant Staphylococcus Aureus And Gram-Positive Bacteria
      14. Anticancer And Antibacterial Activity Of Hyperforin And Its Derivatives
      15. Antidepressant Activity Of Hyperforin Conjugates Of The St.John’S Wort, Hypericum Perforatum Linn.: An Experimental Study
      16. Antidepressant Activity Of Hypericum Perforatum And Hyperforin: The Neglected Possibility
      17. Antidepressant Hyperforin Up-Regulates Vegf In Cns Tumour Cells
      18. Antidepressant-Like Activity Of Hyperforin And Changes In Bdnf And Zinc Levels In Mice Exposed To Chronic Unpredictable Mild Stress
      19. Anti-Proliferative And Anti-Migratory Effects Of Hyperforin In 2D And 3D Artificial Constructs Of Human Dermal Fibroblasts–A New Option For Hypertrophic Scar Treatment?
      20. Antistress And Antioxidant Activity In Mice After Repeated Treatment With St. John’S Wort Extracts Of Different Hyperforin Content
      21. Arbuscular Mycorrhizal Fungi Altered The Hypericin, Pseudohypericin, And Hyperforin Content In Flowers Of Hypericum Perforatum Grown Under Contrasting P Availability …
      22. Aristoforin, A Novel Stable Derivative Of Hyperforin, Is A Potent Anticancer Agent
      23. Biological Evaluation Of Hyperforin And Its Hydrogenated Analogue On Bacterial Growth And Biofilm Production
      24. Biosynthesis Of Hyperforin And AdHyperforin From Amino Acid Precursors In Shoot Cultures Of Hypericum Perforatum
      25. Biosynthesis Of Hyperforin In Hypericum Perforatum
      26. Biosynthetic And Total Synthetic Approaches For (+)-Hyperforin: A Potent Antidepressant Agent From Hypericum Perforatum Linn.(St. John’S Wort)
      27. Biotechnological Production Of Hyperforin For Pharmaceutical Formulation
      28. Catalytic Asymmetric Total Synthesis Of Ent‐Hyperforin
      29. Cellular And Molecular Effects Of The Antidepressant Hyperforin On Brain Cells: Review Of The Literature
      30. Chemical Unstability And Pharmacological Activity Of Hyperforin
      31. Chemistry And Biology Of The Polycyclic Polyprenylated Acylphloroglucinol Hyperforin
      32. Chemistry Of St. John’S Wort: Hypericin And Hyperforin
      33. Clinical Significance Of Hyperforin For The Efficacy Of Hypericum Extracts On Depressive Disorders Of Different Severities
      34. Comparison Of Methods For The Exhaustive Extraction Of Hypericins, Flavonoids, And Hyperforin From Hypericum Perforatum L.
      35. Computed Regioselectivity And Conjectured Biological Activity Of Ene Reactions Of Singlet Oxygen With The Natural Product Hyperforin
      36. Construction Of Highly Functionalized Medium‐Sized Rings: Synthesis Of Hyperforin And Perforatumone Model Systems
      37. Content Of Antidepressant Hyperforin Correlates With Translucent Glands In Hypericum Perforatum L.
      38. Correlation Of Hyperforin Content Of Hypericum Perforatum (St John’S Wort) Extracts With Their Effects On Alcohol Drinking In C57Bl/6J Mice: A Preliminary Study
      39. Cover Picture: Oxidative Fragmentation Of The Bridged Β‐Triketone Core Of Hyperforin (Eur. J. Org. Chem. 6/2004)
      40. Cover Picture: Phloroglucinol Derivatives Guttiferone G, Aristoforin, And Hyperforin: Inhibitors Of Human Sirtuins Sirt1 And Sirt2 (Angew. Chem. Int. Ed. 27/2007)
      41. Cyp3A-Inducing Effect Of Hyperforin And Derivatives In Rodents
      42. Design And Synthesis Of Novel Hyperforin Analogues-Fascinating Skeletal Rearrangements Of Polycyclic Polyprenylated Acylphloroglucinols Core
      43. Detection Of Hyperforin In Turkish Species Of Hypericum (Guttiferae)
      44. Determination Of Hyperforin In Human Plasma Using Solid-Phase Extraction And High-Performance Liquid Chromatography With Ultraviolet Detection
      45. Determination Of Hyperforin In Mouse Brain By High-Performance Liquid Chromatography/Tandem Mass Spectrometry
      46. Determination Of Hyperforin, Hypericin, And Pseudohypericin In Human Plasma Using High-Performance Liquid Chromatography Analysis With Fluorescence And …
      47. Determination Of Hypericin And Hyperforin Content In Different Phytopharmaceuticals And Dietary Supplements Containing Hypericum Perforatum Extract
      48. Determination Of Hypericin And Hyperforin Content In Selected Jordanian Hypericum Species
      49. Development Of A High-Performance Liquid Chromatographic Method With Electrochemical Detection For The Determination Of Hyperforin
      50. Development Of A Simple, Rapid And Reproducible Hplc Assay For The Simultaneous Determination Of Hypericins And Stabilized Hyperforin In Commercial St. John’S Wort …
      51. Differential Accumulation Of Hyperforin And SecoHyperforin In Hypericum Perforatum Tissue Cultures
      52. Divergent Effects Of Hyperforin On The Release Of Arachidonic Acid In Human Platelets And Polymorphonuclear Leukocytes
      53. Dna-Protective Activities Of Hyperforin And Aristoforin
      54. Downregulation Of Β1‐Adrenergic Receptors In Rat C6 Glioblastoma Cells By Hyperforin And Hyperoside From St John’S Wort
      55. Downstream Processing Of Hyperforin From Hypericum Perforatum Root Cultures
      56. Drug Membrane Transporters And Cyp3A4 Are Affected By Hypericin, Hyperforin Or Aristoforin In Colon Adenocarcinoma Cells
      57. Dual Modulation Of Striatal Acetylcholine Release By Hyperforin, A Constituent Of St. John’S Wort
      58. Effect Of Borneol And Electroacupuncture On The Distribution Of Hyperforin In The Rat Brain*,*,★
      59. Effect Of Eluent Ph On The Hplc‐Uv Analysis Of Hyperforin From St. John’S Wort (Hypericum Perforatum L.)
      60. Effect Of Hyperforin On Apoptosis Of Cancer Cells By Inhibiting Rxr Transcriptional Activity
      61. Effect Of Hyperforin On Learning And Memory Abilities And Aβ₁₋ ₄₂, Βapp And Bace1 Protein Expressions In Hippocampus Of Alzheimer’S Disease Model Mice
      62. Effect Of Hyperforin-Enriched Extract On Pro-Ejaculatory Effect Of 8-Hydroxy-2-(Di-N-Propylamino) Tetralin In Anesthetized Rats
      63. Effect Of The St. John’S Wort Constituent Hyperforin On Docetaxel Metabolism By Human Hepatocyte Cultures
      64. Effects Of A Methanolic Extract And A Hyperforin-Enriched Co2 Extract Of Hypericum Perforatum On Alcohol Intake In Rats
      65. Effects Of A Methanolic Extract And A Hyperforin-Enriched Co2 Extract Of St. John’S Wort (Hypericum Perforatum) On Intracerebral Field Potentials In The Freely Moving Rat …
      66. Effects Of Acetylate Hyperforin On The Processing Of Amyloid Precursor Protein
      67. Effects Of Cytokinins And Elicitors On The Production Of Hypericins And Hyperforin Metabolites In Hypericum Sampsonii And Hypericum Perforatum
      68. Effects Of Hyperforin On The Fluidity Of Brain Membranes
      69. Effects Of Hypericum Perforatum Hydroalcoholic Extract, Hypericin, And Hyperforin On Cytotoxicity And Cyp3A4 Mrna Expression In Hepatic Cell Lines: A Comparative …
      70. Effects Of St John’S Wort And Its Active Constituents, Hypericin And Hyperforin, On Isolated Rat Urinary Bladder
      71. Electrochemical Oxidation Of Hyperforin On Glassy Carbon Electrode And Determination In Herbal Medicinal Products
      72. Elevated Carbon Supply Altered Hypericin And Hyperforin Contents Of St. John’S Wort (Hypericum Perforatum L. Cv `New Stem’) Grown In Bioreactors
      73. Enhancement Of Proteolytic Processing Of The Β-Amyloid Precursor Protein By Hyperforin
      74. Enhancement Of Skin Radical Scavenging Activity And Stratum Corneum Lipids After The Application Of A Hyperforin-Rich Cream
      75. Enrichment Of Hyperforin From St. John’S Wort (Hypericum Perforatum) By Pilot-Scale Supercritical Carbon Dioxide Extraction
      76. Estrogenic Activity Of Hyperforin In Mcf-7 Human Breast Cancer Cells Transfected With Estrogen Receptor
      77. European Journal Of Pharmaceutics And Biopharmaceutics Anti-Proliferative And Anti-Migratory Effects Of Hyperforin In 2D And 3D Artificial Constructs Of Human …
      78. European Journal Of Pharmaceutics And Biopharmaceutics Biotechnological Production Of Hyperforin For Pharmaceutical Formulation
      79. European Journal Of Pharmaceutics And Biopharmaceutics Downstream Processing Of Hyperforin From Hypericum Perforatum Root Cultures
      80. Evaluation Of Hyperforin Analogues For Inhibition Of 5-Lipoxygenase
      81. Extraction Of Hyperforin And AdHyperforin From St. John’S Wort (Hypericum Perforatum L.) By Supercritical Carbon Dioxide
      82. Extraction Of Hyperforin And Hypericin From St. John’S Wort (Hypericum Perforatum L.) With Different Solvents
      83. Fluid Extraction On-Line Coupled With Liquid Chromatography-Uv Absorbance/Electrospray Mass Spectrometry For The Determination Of Hyperforin And Its Degradation …
      84. Fluoxetine And Hyperforin Appear To Act Like A Known Glutamate Reuptake Inhibitor By Increasing Epsp Duration In The Crayfish Neuromuscular Junction
      85. From Ulcers To Depression: How Hyperforin Can Help
      86. Further Degradation Product Of Hyperforin From Hypericum Perforatum (St. John’S Wort)
      87. High-Performance Liquid Chromatography Measurement Of Hyperforin And Its Reduced Derivatives In Rodent Plasma
      88. High-Performance Liquid Chromatography–Electrospray Ionization Mass Spectrometry And Multiple Mass Spectrometry Studies Of Hyperforin Degradation Products
      89. Hplc Separation Of The Hyperforin/AdHyperforin Mixture Isolated From Hypericum Perforatum L.
      90. Hyperforin
      91. Hyperforin A Constituent Of St John’S Wort (Hypericum Perforatum L.) Extract Induces Apoptosis By Triggering Activation Of Caspases And With Hypericin Synergistically …
      92. Hyperforin Activates Gene Transcription Involving Transient Receptor Potential C6 Channels
      93. Hyperforin Activates Nonselective Cation Channels–A New Mechanism Of Antidepressant Activity
      94. Hyperforin Activates Trp Channels Via Tyrosine Kinases
      95. Hyperforin Activates Trpc6 Channels And Modulates Trpc6 And L-Type Calcium Channel Crosstalk In Cardiomyocytes
      96. Hyperforin Acts As An Angiogenesis Inhibitor In Vitro And In Vivo
      97. Hyperforin Alleviates Mood Deficits Of Adult Rats Suffered From Early Separation
      98. Hyperforin Analogues From St. John’S Wort (Hypericum Perforatum)
      99. Hyperforin And Aristoforin Inhibit Lymphatic Endothelial Cell Proliferation In Vitro And Suppress Tumor‐Induced Lymphangiogenesis In Vivo
      100. Hyperforin And Deoxycohumulone As A Larvicidal Agent Against Culex Pipiens (Diptera: Culicidae)
      101. Hyperforin And Deoxycohumulone As Potential Larvicidal Mosquito Agents
      102. Hyperforin And Efficacy In Animal Models For Anxiety And Cognition
      103. Hyperforin And Its Analogues Inhibit Cyp3A4 Enzyme Activity
      104. Hyperforin And Miquelianin From St. Johnʼs Wort Attenuate Gene Expression In Neuronal Cells After Dexamethasone-Induced Stress
      105. Hyperforin As A Possible Antidepressant Component Of Hypericum Extracts
      106. Hyperforin As Cytostatic Agent And Hyperforin Ointment Or Cream As Application Form
      107. Hyperforin Attenuates Aluminum-Induced Aβ Production And Tau Phosphorylation Via Regulating Akt/Gsk-3Β Signaling Pathway In Pc12 Cells
      108. Hyperforin Attenuates Brain Damage Induced By Transient Middle Cerebral Artery Occlusion (Mcao) In Rats Via Inhibition Of Trpc6 Channels Degradation
      109. Hyperforin Attenuates Microglia Activation And Inhibits P65-Ser276 Nfκb Phosphorylation In The Rat Piriform Cortex Following Status Epilepticus
      110. Hyperforin Attenuates Various Ionic Conductance Mechanisms In The Isolated Hippocampal Neurons Of Rat
      111. Hyperforin Blocks Neutrophil Activation Of Matrix Metalloproteinase-9, Motility And Recruitment, And Restrains Inflammation-Triggered Angiogenesis And Lung Fibrosis
      112. Hyperforin Changes The Zinc-Storage Capacities Of Brain Cells
      113. Hyperforin Content Of St John’S Wort Products And Drug Interactions
      114. Hyperforin Contributes To The Hepatic Cyp3A-Inducing Effect Of Hypericum Perforatum Extract In The Mouse
      115. Hyperforin Depletes Synaptic Vesicles Content And Induces Compartmental Redistribution Of Nerve Ending Monoamines
      116. Hyperforin Derivatives, The Use Thereof And Formulations Containing Them
      117. Hyperforin Down‐Regulates Effector Function Of Activated T Lymphocytes And Shows Efficacy Against Th1‐Triggered Cns Inflammatory‐Demyelinating Disease
      118. Hyperforin Exhibits Antigenotoxic Activity On Human And Bacterial Cells
      119. Hyperforin Halogenated Derivatives, The Use Thereof And Formulations Containing Them
      120. Hyperforin Improves Post-Stroke Social Isolation‑Induced Exaggeration Of Psd And Psa Via Tgf-Β
      121. Hyperforin In Extracts Of St John’S Wort (Hypericum Perforatum) For Depression
      122. Hyperforin In Extracts Of St John’S Wort (Hypericum Perforatum) For Depression—Reply
      123. Hyperforin In St. John’S Wort Drug Interactions
      124. Hyperforin In St. John’S Wort’S Central Effects: What Is The Mechanism Of Action?
      125. Hyperforin Induces Apoptosis Of Chronic Lymphocytic Leukemia Cells Through Upregulation Of The Bh3-Only Protein Noxa
      126. Hyperforin Induces Apoptosis Through Extrinsic/Intrinsic Pathways And Inhibits Nf-ĸb-Modulated Survival And Invasion Potential In Bladder Cancer
      127. Hyperforin Induces Ca2+-Independent Arachidonic Acid Release In Human Platelets By Facilitating Cytosolic Phospholipase A2 Activation Through Select Phospholipid …
      128. Hyperforin Induces Senescence In Endothelial And Tumor Cells
      129. Hyperforin Inhibits Akt1 Kinase Activity And Promotes Caspase-Mediated Apoptosis Involving Bad And Noxa Activation In Human Myeloid Tumor Cells
      130. Hyperforin Inhibits Cancer Invasion And Metastasis
      131. Hyperforin Inhibits Cell Growth By Inducing Intrinsic And Extrinsic Apoptotic Pathways In Hepatocellular Carcinoma Cells
      132. Hyperforin Inhibits Cell Proliferation And Differentiation In Mouse Embryonic Stem Cells
      133. Hyperforin Inhibits Mmp-9 Secretion By B-Cll Cells And Microtubule Formation By Endothelial Cells
      134. Hyperforin Inhibits P-Gp And Bcrp Activities In Chronic Lymphocytic Leukaemia Cells And Myeloid Cells
      135. Hyperforin Inhibits Vesicular Uptake Of Monoamines By Dissipating Ph Gradient Across Synaptic Vesicle Membrane
      136. Hyperforin Is A Dual Inhibitor Of Cyclooxygenase-1 And 5-Lipoxygenase
      137. Hyperforin Is A Modulator Of Inducible Nitric Oxide Synthase And Phagocytosis In Microglia And Macrophages
      138. Hyperforin Is A Novel Type Of 5-Lipoxygenase Inhibitor With High Efficacy In Vivo
      139. Hyperforin Is A Potent Inhibitor Of Inflammation-Triggered Angiogenesis
      140. Hyperforin Mediated Pxr Activation Is Influenced By The Uptake Transporter Oatp2B1
      141. Hyperforin Mediates Neurite Outgrowth Via Trpc6 Channels In Pc12 Cells
      142. Hyperforin Modulates Dendritic Spine Morphology In Hippocampal Pyramidal Neurons By Activating Ca2+‐Permeable Trpc6 Channels
      143. Hyperforin Modulates Gating Of P-Type Ca2+ Current In Cerebellar Purkinje Neurons
      144. Hyperforin Plasma Level As A Marker Of Treatment Adherence In The National Institutes Of Health Hypericum Depression Trial
      145. Hyperforin Potentiates Antidepressant-Like Activity Of Lanicemine In Mice
      146. Hyperforin Prevents Β-Amyloid Neurotoxicity And Spatial Memory Impairments By Disaggregation Of Alzheimer’S Amyloid-Β-Deposits
      147. Hyperforin Production In Hypericum Perforatum Root Cultures
      148. Hyperforin Promotes Mitochondrial Function And Development Of Oligodendrocytes
      149. Hyperforin Promotes Post-Stroke Functional Recovery Through Interleukin (Il)− 17A-Mediated Angiogenesis
      150. Hyperforin Promotes Post-Stroke Neuroangiogenesis Via Astrocytic Il-6-Mediated Negative Immune Regulation In The Ischemic Brain
      151. Hyperforin Protects Against Acute Cerebral Ischemic Injury Through Inhibition Of Interleukin-17A-Mediated Microglial Activation
      152. Hyperforin Represents The Neurotransmitter Reuptake Inhibiting Constituent Of Hypericum Extract
      153. Hyperforin Stimulates Intracellular Calcium Mobilisation And Enhances Extracellular Acidification In Ddt1-Mf2 Smooth Muscle Cells
      154. Hyperforin Suppresses Tumor Growth And Nf-Κb-Mediated Anti-Apoptotic And Invasive Potential Of Non-Small Cell Lung Cancer
      155. Hyperforin Synthetic Studies
      156. Hyperforin, A Bio‐Active Compound Of St. John’S Wort, Is A New Inhibitor Of Angiogenesis Targeting Several Key Steps Of The Process
      157. Hyperforin, A Major Lipophilic Constituent Of St. John’S Wort, Enhances Paclitaxel Sensitivity In Her2 Overexpressing Breast Cancer Cells.
      158. Hyperforin, A New Lead Compound Against The Progression Of Cancer And Leukemia?
      159. Hyperforin, An Anti-Inflammatory Constituent From St. John’S Wort, Inhibits Microsomal Prostaglandin E
      160. Hyperforin, An Anti-Inflammatory Constituent From St. John’S Wort, Inhibits Microsomal Prostaglandin E2 Synthase-1 And Suppresses Prostaglandin E2 Formation …
      161. Hyperforin, Possibly The Major Non-Nitrogenous Secondary Metabolite Of Hypericum Perforatum L.
      162. Hyperforin, The Active Component Of St. John’S Wort, Induces Il-8 Expression In Human Intestinal Epithelial Cells Via A Mapk-Dependent, Nf-Κb-Independent …
      163. Hyperforin/Hp-Β-Cyclodextrin Enhances Mechanosensitive Ca2
      164. Hyperforin: A Lead For Antidepressants
      165. Hyperforin: A Potent Anti-Depressant Natural Drug
      166. Hyperforin: More Than An Antidepressant Bioactive Compound?
      167. Hyperforin: To Be Or Not To Be An Activator Of Trpc (6)
      168. Hyperforin—A Key Constituent Of St. John’S Wort Specifically Activates Trpc6 Channels
      169. Hyperforin-Antidepressant Activity By A Novel Mechanism Of Action
      170. Hyperforin-Containing Extracts Of St John’S Wort Fail To Alter Gene Transcription In Brain Areas Involved In Hpa Axis Control In A Long-Term Treatment Regimen In …
      171. Hyperforin-Induced Activation Of The Pregnane X Receptor Is Influenced By The Organic Anion-Transporting Polypeptide 2B1
      172. Hyperforin-Loaded Gold Nanoparticle Alleviates Experimental Autoimmune Encephalomyelitis By Suppressing Th1 And Th17 Cells And Upregulating Regulatory T Cells
      173. Hypericin And Hyperforin Production In St. John’S Wort In Vitro Culture: Influence Of Saccharose, Polyethylene Glycol, Methyl Jasmonate, And Agrobacterium Tumefaciens
      174. Hypericin And Hyperforin: Bioactive Components Of St. John’S Wort (Hypericum Perforatum). Their Isolation, Analysis And Study Of Physiological Effect
      175. Identification And Quantitative Determination Of Hyperforin In Some Hypericum Species.
      176. Improved Bioactivity Of The Natural Product 5-Lipoxygenase Inhibitor Hyperforin By Encapsulation Into Polymeric Nanoparticles
      177. Improvement Of Hypericin And Hyperforin Production Using Zinc And Iron Nano-Oxides As Elicitors In Cell Suspension Culture Of St John’S Wort (Hypericum …
      178. In Vitro Antimalarial Activity Of Hyperforin, A Prenylated Acylphloroglucinol. A Structure–Activity Study
      179. In Vitro Binding Studies With Two Hypericum Perforatum Extracts-Hyperforin, Hypericin And Biapigenin-On 5-Ht6, 5-Ht7, Gabaa/Benzodiazepine, Sigma, Npy-Y1/Y2 …
      180. In Vitro Effects Of St. John’S Wort Extract And Hyperforin On 5 Ht Uptake And Efflux In Human Blood Platelets
      181. In Vitro Effects Of The Dicyclohexylammonium Salt Of Hyperforin On Interleukin-6 Release In Different Experimental Models
      182. In Vitro Metabolism Of Hyperforin In Rat Liver Microsomal Systems
      183. In Vivo Neurotransmitter Release In The Locus Coeruleus-Effects Of Hyperforin, Inescapable Shock And Fear
      184. In Vivo Photoprotective And Anti-Inflammatory Effect Of Hyperforin Is Associated With High Antioxidant Activity In Vitro And Ex Vivo
      185. Induction Of Apoptosis In K562 Cells By Dicyclohexylammonium Salt Of Hyperforin Through A Mitochondrial-Related Pathway
      186. Induction Of Cyp3A By St. Johns Wort (Sjw) Depends On Hyperforin (Hyf) Dose
      187. Influence Of Hyperforin On The Morphology Of Internal Organs And Biochemical Parameters, In Experimental Model In Mice
      188. Influence Of Hypericum Perforatum L. Extract Stw 3-Vi, Hyperoside, And Hyperforin On The Binding Behavior And Lateral Mobility Of 5-Ht2A-Receptors
      189. Influence Of Hyperoside And Hyperforin On The Regulation Of Β1-Adrenergic Receptors On Living C6 Glioblastoma Cells: A New Postsynaptic Approach For The Mode Of …
      190. Influence Of Saint John’S Wort (Hypericum Perforatum) Constituent Hyperforin On Phagocytosis And Inducible Nitric Oxide Synthase (Inos) In Microglia
      191. Inhibition Of Synaptosomal Uptake Of 3H-L-Glutamate And 3H-Gaba By Hyperforin, A Major Constituent Of St. John’S Wort: The Role Of Amiloride Sensitive Sodium …
      192. Inhibitory Effects Of St. John’S Wort Extract And Its Component Hyperforin On Cytokine-Induced Apoptosis And Inos Expression In Pancreatic Beta Cells By Down …
      193. Instability Of St. John’S Wort (Hypericum Perforatum L.) And Degradation Of Hyperforin In Aqueous Solutions And Functional Beverage
      194. Investigation Of Pharmacokinetic Data Of Hypericin, Pseudohypericin, Hyperforin And The Flavonoids Quercetin And Isorhamnetin Revealed From Single And Multiple Oral …
      195. Investigation Of The Bioavailability Of Hypericin, Pseudohypericin, Hyperforin And The Flavonoids Quercetin And Isorhamnetin Following Single And Multiple Oral Dosing Of …
      196. In-Vitro Antitumor Activity Evaluation Of Hyperforin Derivatives
      197. Lipid Nanocapsules Containing The Non-Ionic Surfactant Solutol Hs15 Inhibit The Transport Of Calcium Through Hyperforin-Activated Channels In Neuronal Cells
      198. Mass Spectral Characterization Of Phloroglucinol Derivatives Hyperforin And AdHyperforin
      199. Measurement Of Hyperforin A Constituent Of St. John’S Wort In Plasma By High-Performance Liquid Chromatography
      200. Mechanisms Of Hyperforin As An Anti-Angiogenic Angioprevention Agent
      201. Mechanistic Insights Into The Antileukemic Activity Of Hyperforin
      202. Men Reporting Lasting Longer With Hyperforin
      203. Metabolism Of Hyperforin, The Active Constituent Of St. John’S Wort, In Human Liver Microsomes
      204. Metacyc Pathway: Hyperforin And AdHyperforin Biosynthesis
      205. Modular Total Syntheses Of Hyperforin, Papuaforins A, B, And C Via Gold (I)-Catalyzed Carbocyclization
      206. Modulating Action Of Hyperforin On The P-Type Calcium Channels In The Membranes Of Rat Cerebellar Purkinje Neurons
      207. Modulation Of Chemoselectivity By Protein Additives. Remarkable Effects In The Oxidation Of Hyperforin
      208. Mp-12.06: Effect Of Hyperforin Enriched Extract On Pro-Ejaculatory Effect Of 8-Oh-Dpat In Anesthetized Rats
      209. Nature’S Antidepressant For Mild To Moderate Depression: Isolation And Spectral Characterization Of Hyperforin From A Standardized Extract Of St. John’S Wort (Hypericum …
      210. Neurobiological Effects Of Hyperforin And Its Potential In Alzheimer’S Disease Therapy
      211. Neuropharmacology Of Genus Hypericum: Hypericin And Hyperforin
      212. Neuroprotective Role Of Hyperforin On Aluminum Maltolate-Induced Oxidative Damage And Apoptosis In Pc12 Cells And Sh-Sy5Y Cells
      213. New Hyperforin Derivatives From Hypericum Revolutum Vahl With Growth‐Inhibitory Activity Against A Human Colon Carcinoma Cell Line
      214. New Theoretical Insights On Tautomerism Of Hyperforin—A Prenylated Phloroglucinol Derivative Which May Be Responsible For St. John’S Wort (Hypericum …
      215. Nmda Receptor-Antagonistic Properties Of Hyperforin, A Constituent Of St. John’S Wort
      216. No Activation Of Human Pregnane X Receptor By Hyperforin-Related Phloroglucinols
      217. No Clinically Relevant Cyp3A Induction After St. John’S Wort With Low Hyperforin Content In Healthy Volunteers
      218. No Clinically Relevant Interactions Of St. John’S Wort Extract Ze 117 Low In Hyperforin With Cytochrome P450 Enzymes And P‐Glycoprotein
      219. No Relevant Interaction With Alprazolam, Caffeine, Tolbutamide, And Digoxin By Treatment With A Low-Hyperforin St John’S Wort Extract
      220. Novel Insights Into The Effect Of Hyperforin And Photodynamic Therapy With Hypericin On Chosen Angiogenic Factors In Colorectal Micro-Tumors Created On …
      221. Noxa Upregulation Is Associated With Apoptosis Of Chronic Lymphocytic Leukemia Cells Induced By Hyperforin But Not Flavopiridol
      222. Of An Hypericum Perforatum (St. John’S Wort) Extract In Preventing And Reverting A Condition Of Escape Deficit In Rats-The Relevance Of Hyperforin For The Clinical …
      223. Of Serotoninergic 5-Ht1A/2A, Alpha-Adrenergic And Dopaminergic D1 Receptors In St. John’S Wort-Induced Prepulse Inhibition Deficit: A Possible Role Of Hyperforin
      224. On Artemisinin, Cyclopamine, D-Isocitric Acid, Hyperforin, Epigenetics, Sialic Acid, And More
      225. Ontogenetic Variation Regarding Hypericin And Hyperforin Levels In Four Accessions Of Hypericum Perforatum L.
      226. Optimization Of Supercritical Fluid Extraction For The Separation Of Hyperforin And AdHyperforin In St. John’S Wort (Hypericum Perforatum L.)
      227. Oral Bioavailability Of Hyperforin From Hypericum Extracts In Rats And Human Volunteers
      228. Oxidative Chemistry Of Hyperforin, The Major Phloroglucinol From St. John’S Wort
      229. Oxidative Fragmentation Of The Bridged Β‐Triketone Core Of Hyperforin
      230. Persistence Of Stat‐1 Inhibition And Induction Of Cytokine Resistance In Pancreatic Β Cells Treated With St John’S Wort And Its Component Hyperforin
      231. Phloroglucinol Derivatives Guttiferone G, Aristoforin, And Hyperforin: Inhibitors Of Human Sirtuins Sirt1 And Sirt2
      232. Photochemical Degradation Of Hyperforin
      233. Physiologically Based Pharmacokinetic Modelling Of Hyperforin To Predict Drug Interactions With St John’S Wort
      234. Potential Anticlastogenic Effect Of Hyperforin
      235. Potential Antidepressant Properties Of Idn 5491 (Hyperforin–Trimethoxybenzoate), A Semisynthetic Ester Of Hyperforin
      236. Pro-Apoptotic Properties Of Hyperforin In Leukemic Cells From Patients With B-Cell Chronic Lymphocytic Leukemia
      237. Process Optimization For The Extraction Of Hyperforin And Hypericin From St. John’S Wort
      238. Profiling Auspicious Butyrylcholinesterase Inhibitory Activity Of Two Herbal Molecules: Hyperforin And Hyuganin C
      239. Protective Effect Of Hyperforin On Β Amyloid Protein Induced Apoptosis In Pc12 Cells And Colchicine Induced Alzheimer’S Disease: An Anti-Oxidant And Anti-Inflammatory …
      240. Protective Effects Of St. John’S Wort Extract And Its Component Hyperforin Against Cytokine-Induced Cytotoxicity In A Pancreatic Β-Cell Line
      241. Protonophore Properties Of Hyperforin Are Essential For Its Pharmacological Activity
      242. Pseudohypericin And Hyperforin In Hypericum Perforatum From Northern Turkey: Variation Among Populations, Plant Parts And Phenological Stages
      243. Pseudohypericin And Hyperforin In Two Turkish Hypericum Species: Variation Among Plant Parts And Phenological Stages
      244. Quantitative Changes Of Dianthrones, Hyperforin And Flavonoids Content In The Flower Ontogenesis Of Hypericum Perforatum
      245. Quantitative Characterization Of Direct P‐Glycoprotein Inhibition By St John’S Wort Constituents Hypericin And Hyperforin
      246. Quantitative Determination Of Hyperforin In Hypericum Perforatum By Hplc
      247. Radical Protection In The Visible And Infrared By A Hyperforin‐Rich Cream – In Vivo Versus Ex Vivo Methods
      248. Recent Enhancement Of The Immunity In Aids And Other Immunocompromised Patients By Hyperforin An Antibiotic From Hypericum Perforatum L. (In Vitro …
      249. Reduced Alzheimer’S Disease Pathology By St. John’S Wort Treatment Is Independent Of Hyperforin And Facilitated By Abcc1 And Microglia Activation In Mice
      250. Reduction Of High-Affinity Β2-Adrenergic Receptor Binding By Hyperforin And Hyperoside On Rat C6 Glioblastoma Cells Measured By Fluorescence Correlation …
      251. Research On The Antidepressant Effect Of The Association Hyperforin-Sertralin
      252. Reveals A Distinct Molecular Profile Of Cellular Stress Following Incubation Of Ddt1-Mf2 Smooth Muscle Cells In The Presence Of A High Concentration Of Hyperforin
      253. Role Of Hyperforin In Diabetes And Its Associated Hyperlipidemia In Rats
      254. Separate Isolation Of Hyperforin From Hypericum Perforatum (St. John’S Wort) Pursuant To The Coefficents Log Kow, Pka And …
      255. Short Term Treatment With St. John’S Wort, Hypericin Or Hyperforin Fails To Induce Cyp450 Isoforms In The Swiss Webster Mouse
      256. Simultaneous Determination Of Hypericin And Hyperforin In Human Plasma And Serum Using Liquid–Liquid Extraction, High-Performance Liquid Chromatography And …
      257. Simultaneous Determination Of Hypericin And Hyperforin In Human Plasma With Liquid Chromatography–Tandem Mass Spectrometry
      258. Simultaneous Determination Of Total Hypericin And Hyperforin In St. John’S Wort Extracts By Hplc With Electrochemical Detection
      259. Single-Drop Liquid-Phase Microextraction For The Determination Of Hypericin, Pseudohypericin And Hyperforin In Biological Fluids By High Performance Liquid …
      260. Some Effects Of Light Quantity And Quality On Secondary Metabolites Hyperforin, Pseudohypericin And Hypericin, In Hypericum Perforatum
      261. St. John’S Wort (Hypericum Perforatum) And Breastfeeding: Concentrations Of Hyperforin In Nursing Infants And Breast Milk
      262. St. John’S Wort (Hypericum Perforatum) And Breastfeeding: Plasma And Breast Milk Concentrations Of Hyperforin For 5 Mothers And 2 Infants.
      263. St. John’S Wort And Its Component Hyperforin Alleviate Experimental Autoimmune Encephalomyelitis Through Expansion Of Regulatory T-Cells
      264. St. John’S Wort Extract And Hyperforin Inhibit Multiple Phosphorylation Steps Of Cytokine Signaling And Prevent Inflammatory And Apoptotic Gene Induction In Pancreatic …
      265. St. John’S Wort Extract And Hyperforin Protect Rat And Human Pancreatic Islets Against Cytokine Toxicity
      266. St. John’S Wort In Mild To Moderate Depression: The Relevance Of Hyperforin For The Clinical Efficacy
      267. Stabilization Of Hyperforin Dicyclohexylammonium Salt With Dissolved Albumin And Albumin Nanoparticles For Studying Hyperforin Effects On 2D Cultivation Of …
      268. Stabilized Hyperforin Solutions For Oral Administration
      269. Stable Hyperforin Salts, Method For Producing Same And Their Use In The Treatment Of Alzheimer’S Disease
      270. Stereoselective Total Synthesis Of (±)-Hyperforin Via Intramolecular Cyclopropanation
      271. Stimulation Of Glutamate, Aspartate And Gamma-Aminobutyric Acid Release From Synaptosomes By Hyperforin
      272. Stimulation Of Hippocampal Acetylcholine Release By Hyperforin, A Constituent Of St. John’S Wort
      273. Store-Depletion And Hyperforin Activate Distinct Types Of Ca2+-Conducting Channels In Cortical Neurons
      274. Structural Investigations Of Isomeric Oxidised Forms Of Hyperforin By Hplc‐Nmr And Hplc‐Msn
      275. Super Antibiotics, Part I. Hyperforin
      276. Super Antibiotics, Part Ii. Hyperforin, Mass Spectroscopy (Ms) And Gas Chromatography-Mass Spectrometry (Gc-Ms), Evidence Of Permeability Of The Blood …
      277. Super Antibiotics, Part Iv. Hyperforin, Relative And Absolute Stereochemistry Elucidated By Gas-Chromatography Mass-Spectrometry With Supersonic …
      278. Super Antibiotics, Part Vi: Hyperforin, Revision Of Stereochemistry. Short Communications
      279. Super Antibiotics: Part Iii. Hyperforin, Revision Of The Relative And Absolute Stereochemistry Presented By Bystrov Et Al.
      280. Suppression Of Receptor-Mediated Ca2+ Mobilization And Functional Leukocyte Responses By Hyperforin
      281. Synthesis And Biological Evaluation Of Hyperforin Analogues. Part I. Modification Of The Enolized Cyclohexanedione Moiety
      282. Synthesis Of Ent-Hyperforin
      283. Synthesis Of Hyperforin
      284. Synthesis Of The Core Bicyclic System Of Hyperforin And Nemorosone
      285. Synthetic Approach To Bonandiol And Hyperforin.
      286. Synthetic Studies Toward The Ppap Natural Products, Prolifenones A And B And Hyperforin: An Effenberger Cyclization Approach
      287. Synthetic Studies Towards The Phloroglucin Natural Product Hyperforin: Construction Of The Fully Prenylated Bicyclic Core
      288. The Acylphloroglucinols Hyperforin And Myrtucommulone A Cause Mitochondrial Dysfunctions In Leukemic Cells By Direct Interference With Mitochondria
      289. The Antidepressant Hyperforin Increases The Phosphorylation Of Creb And The Expression Of Trkb In A Tissue-Specific Manner
      290. The Effect Of St. John’S Wort Supercritical Extract And Hyperforin Solution On Biological Subjects
      291. The Extent Of Induction Of Cyp3A By St. John’S Wort Varies Among Products And Is Linked To Hyperforin Dose
      292. The First Catalytic Asymmetric Total Synthesis Of Ent-Hyperforin
      293. The First Prenylation Step In Hyperforin Biosynthesis
      294. The Hyperforin Derivative Idn5706 Occludes Spatial Memory Impairments And Neuropathological Changes In A Double Transgenic Alzheimer’S Mouse Model
      295. The Involvement Of Sodium And Calcium Ions In The Release Of Amino Acid Neurotransmitters From Mouse Cortical Slices Elicited By Hyperforin
      296. The Potential Of Hypericin And Hyperforin For Antiadhesion Therapy To Prevent Metastasis Of Parental And Oxaliplatin-Resistant Human Adenocarcinoma Cells (Ht-29)
      297. The Pro-Apoptotic And Anti-Invasive Effects Of Hypericin-Mediated Photodynamic Therapy Are Enhanced By Hyperforin Or Aristoforin In Ht-29 Colon Adenocarcinoma …
      298. The Production Of Hypericins And Hyperforin By In Vitro Cultures Of St. John’S Wort (Hypericum Perforatum)
      299. The Reaction Of Hyperforin With Hydride Reducing Agents
      300. The Total Synthesis Of Hyperforin
      301. The Trpc6 Channel Activator Hyperforin Induces The Release Of Zinc And Calcium From Mitochondria
      302. Topical Application Of St John’S Wort (Hypericum Perforatum L.) And Of Its Metabolite Hyperforin Inhibits The Allostimulatory Capacity Of Epidermal Cells
      303. Total Syntheses Of Hyperforin And Papuaforins A–C
      304. Total Syntheses Of Hyperforin And Papuaforins A–C, And Formal Synthesis Of Nemorosone Through A Gold (I)‐Catalyzed Carbocyclization
      305. Total Synthesis Of (+)-Hyperforin
      306. Total Synthesis Of Hyperforin
      307. Toward Enhanced Hyperforin Production In St. John’S Wort Root Cultures
      308. Towards The Total Synthesis Of Polycyclic Polyprenylated Acyl Phloroglucin (Ppap) Natural Products: Garsubellin A And Hyperforin
      309. Treatment With Hypericum Perforatum L. Does Not Trigger Decreased Resistance In Staphylococcus Aureus Against Antibiotics And Hyperforin
      310. Trpc6 Activator Hyperforin Facilitates Arrhythmias Via Activating Store-Operated Calcium Entry
      311. Ultrasonic Extraction Of Hyperforin And Its Assay With Hplc
      312. Understanding Drug Interactions With St John’S Wort (Hypericum Perforatum L.): Impact Of Hyperforin Content
      313. Use Of Hyperforin And Hyperforin-Containing Extracts In The Treatment And Prophylaxis Of Dementing Diseases
      314. Use Of Hyperforin For Treating Cancer, Or In Topical Compositions Optionally Together With Hypericin For Treating Eg Inflammatory Skin Disease, Skin Aging Or Bacterial Skin …
      315. Variability Of Hypericins And Hyperforin In Hypericum Species From The Sicilian Flora
      316. Variation Of Hyperforin In Hypericum Montbretii During Its Phenological Cycle
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