NON OPIOD ANALGESICS
March 22, 2021ISOFLAVONES
March 22, 2021- Mechanism of action of the immunosuppressant Rapamycin
- Rapamycin in transplantation: a review of the evidence
- Rapamycin: Clinical Results and Future Opportunities1
- Targets for cell cycle arrest by the immunosuppressant Rapamycin in yeast
- The target of Rapamycin (TOR) proteins
- Solubilization of Rapamycin
- Rapamune (Sirolimus, Rapamycin): an overview and mechanism of action.
- Total synthesis of Rapamycin
- Activity of Rapamycin (AY-22, 989) against transplanted tumors
- Rapamycin suppresses 5′TOP mRNA translation through inhibition of p70s6k
- SDZ RAD, a new Rapamycin derivative: pharmacological properties in vitro and in vivo
- Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase
- Regulation of cellular growth by the Drosophila target of Rapamycin dTOR
- Bench to bedside: the development of Rapamycin and its application to stent restenosis
- Rapamycin (AY-22, 989), a new antifungal antibiotic II. Fermentation, isolation and characterization
- Two TOR complexes, only one of which is Rapamycin sensitive, have distinct roles in cell growth control
- Rapamycin (AY-22, 989), a new antifungal antibiotic I. Taxonomy of the producing streptomycete and isolation of the active principle
- The Rapamycin-sensitive signal transduction pathway as a target for cancer therapy
- A mammalian protein targeted by G1-arresting Rapamycin–receptor complex
- Rapamycin inhibits vascular smooth muscle cell migration.
- TOR mutations confer Rapamycin resistance by preventing interaction with FKBP12-Rapamycin
- Isolation of a protein target of the FKBP12-Rapamycin complex in mammalian cells
- Rapamycin selectively represses translation of the” polypyrimidine tract” mRNA family
- Phosphorylation of the translational repressor PHAS-I by the mammalian target of Rapamycin
- Rapamycin: distribution, pharmacokinetics and therapeutic range investigations: an update.
- Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor
- Elucidating TOR signaling and Rapamycin action: lessons from Saccharomyces cerevisiae
- Biosynthesis of erythromycin and Rapamycin
- Blood distribution of Rapamycin.
- Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of Rapamycin
- Regulation of hypoxia-inducible factor 1α expression and function by the mammalian target of Rapamycin
- Studies on the mechanism of resistance to Rapamycin in human cancer cells
- A Rapamycin-sensitive signaling pathway contributes to long-term synaptic plasticity in the hippocampus
- Rapamycin: distribution, pharmacokinetics, and therapeutic range investigations.
- Rapamycin blocks tumor progression: unlinking immunosuppression from antitumor efficacy1
- Structure of the FKBP12-Rapamycin complex interacting with binding domain of human FRAP
- Expression and disruption of the Arabidopsis TOR (target of Rapamycin) gene
- Rapamycin enhances apoptosis and increases sensitivity to cisplatin in vitro
- The biosynthetic gene cluster for the polyketide immunosuppressant Rapamycin
- Mammalian target of Rapamycin (mTOR): pro-and anti-apoptotic
- SDZ RAD, a new Rapamycin derivative: synergism with cyclosporine
- Rapamycin (AY-22, 989), A NEW ANTIFUNGAL ANTIBIOTIC III. IN VITRO AND IN VIVO EVALUATION
- RAFT1: a mammalian protein that binds to FKBP12 in a Rapamycin-dependent fashion and is homologous to yeast TORs
- p53/p21CIP1 cooperate in enforcing Rapamycin-induced G1 arrest and determine the cellular response to Rapamycin
- Raptor, a binding partner of target of Rapamycin (TOR), mediates TOR action
- Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase
- The principal target of Rapamycin‐induced p70s6k inactivation is a novel phosphorylation site within a conserved hydrophobic domain.
- Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases
- The immunosuppressant Rapamycin mimics a starvation-like signal distinct from amino acid and glucose deprivation
- Rapamycin-FKBP inhibits cell cycle regulators of proliferation in vascular smooth muscle cells
- TOR kinase domains are required for two distinct functions, only one of which is inhibited by Rapamycin
- inhibition of cell cycle progression by Rapamycin induces T cell clonal anergy even in the presence of costimulation
- Revised NMR assignments for Rapamycin
- Rapamycin blocks the phosphorylation of 4E‐BP1 and inhibits cap‐dependent initiation of translation.
- Absorption and intestinal metabolism of SDZ-RAD and Rapamycin in rats
- Rapamycin resistance tied to defective regulation of p27Kip1.
- RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/Rapamycin complex
- Targeted disruption of p70s6k defines its role in protein synthesis and Rapamycin sensitivity
- Target of Rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression
- Rapamycin prolongs survival and arrests pathophysiologic changes in murine systemic lupus erythematosus
- Rapamycin-modulated transcription defines the subset of nutrient-sensitive signaling pathways directly controlled by the Tor proteins
- SIROLIMUS (Rapamycin)-BASED THERAPY IN HUMAN RENAL TRANSPLANTATION: Similar Efficacy and Different Toxicity Compared with Cyclosporine: 1, 2
- Inhibitors of mammalian target of Rapamycin as novel antitumor agents: from bench to clinic
- Cytoplasmic–nuclear shuttling of FKBP12-Rapamycin-associated protein is involved in Rapamycin-sensitive signaling and translation initiation
- A protein kinase B-dependent and Rapamycin-sensitive pathway controls skeletal muscle growth but not fiber type specification
- Rapamycin inhibition of the G1 to S transition is mediated by effects on cyclin D1 mRNA and protein stability
- A chemical genomics approach toward understanding the global functions of the target of Rapamycin protein (TOR)
- Mechanism of metabolic control: target of Rapamycin signaling links nitrogen quality to the activity of the Rtg1 and Rtg3 transcription factors
- Leucine stimulates translation initiation in skeletal muscle of postabsorptive rats via a Rapamycin-sensitive pathway
- inhibition of human B lymphocyte cell cycle progression and differentiation by Rapamycin
- Mammalian target of Rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on …
- Two distinct signal transmission pathways in T lymphocytes are inhibited by complexes formed between an immunophilin and either FK506 or Rapamycin.
- Cyclosporin A, FK506 and Rapamycin: more than just immunosuppression
- Rapamycin inhibits human adipocyte differentiation in primary culture
- Rapamycin impairs recovery from acute renal failure: role of cell-cycle arrest and apoptosis of tubular cells
- inhibition of T and B lymphocyte proliferation by Rapamycin.
- Target of Rapamycin (TOR): balancing the opposing forces of protein synthesis and degradation
- Partitioning the transcriptional program induced by Rapamycin among the effectors of the Tor proteins
- Rapamycin (AY-22, 989), A NEW ANTIFUNGAL ANTIBIOTIC IV. MECHANISM OF ACTION
- Control of translation by the target of Rapamycin proteins
- Control of Ser2448 phosphorylation in the mammalian target of Rapamycin by insulin and skeletal muscle load
- Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of Rapamycin mediated by a protein kinase B signaling pathway
- Serum‐stimulated, Rapamycin‐sensitive phosphorylation sites in the eukaryotic translation initiation factor 4GI
- Rapamune®(RAPA, Rapamycin, sirolimus): mechanism of action immunosuppressive effect results from blockade of signal transduction and inhibition of cell cycle …
- Regulation of Ribosome Biogenesis by the Rapamycin-sensitive TOR-signaling Pathway in Saccharomyces cerevisiae
- Enhancement of human platelet aggregation and secretion induced by Rapamycin.
- A Rapamycin-sensitive pathway down-regulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1
- Biochemical correlates of mTOR inhibition by the Rapamycin ester CCI-779 and tumor growth inhibition
- The mammalian target of Rapamycin regulates C2C12 myogenesis via a kinase-independent mechanism
- Hypoxia enhances vascular cell proliferation and angiogenesis in vitro via Rapamycin (mTOR)‐dependent signaling
- Rapamycin, wortmannin, and the methylxanthine SQ20006 inactivate p70s6k by inducing dephosphorylation of the same subset of sites
- Immunopurified mammalian target of Rapamycin phosphorylates and activates p70 S6 kinase α in vitro
- The principal Rapamycin-sensitive p70 (s6k) phosphorylation sites, T-229 and T-389, are differentially regulated by Rapamycin-insensitive kinase kinases.
- Direct inhibition of the signaling functions of the mammalian target of Rapamycin by the phosphoinositide 3‐kinase inhibitors, wortmannin and LY294002.
- The Rapamycin-binding domain governs substrate selectivity by the mammalian target of Rapamycin
- Rapamycin inhibits clonal expansion and adipogenic differentiation of 3T3-L1 cells
- Interaction of RAFT1 with gephyrin required for Rapamycin-sensitive signaling
- Rapamycin causes poorly reversible inhibition of mTOR and induces p53-independent apoptosis in human rhabdomyosarcoma cells
- Suppression of B cell activation by cyclosporin A, FK506 and Rapamycin
- Rapamycin selectively inhibits translation of mRNAs encoding elongation factors and ribosomal proteins
- Rapamycin and FK506 binding proteins (immunophilins)
- Rapamycin inhibits hepatic stellate cell proliferation in vitro and limits fibrogenesis in an in vivo model of liver fibrosis
- On the chemistry and high field nuclear magnetic resonance spectroscopy of Rapamycin
- Solution structure of FKBP, a rotamase enzyme and receptor for FK506 and Rapamycin
- Neurotrophic actions of nonimmunosuppressive analogues of immunosuppressive drugs FK506, Rapamycin and cyclosporin A
- Activated mammalian target of Rapamycin pathway in the pathogenesis of tuberous sclerosis complex renal tumors
- inhibition of the mammalian target of Rapamycin sensitizes U87 xenografts to fractionated radiation therapy
- Atomic structure of the Rapamycin human immunophilin FKBP-12 complex
- The FKBP12-Rapamycin-binding domain is required for FKBP12-Rapamycin-associated protein kinase activity and G1 progression
- A novel pathway regulating the mammalian target of Rapamycin (mTOR) signaling
- Serine phosphorylation and maximal activation of STAT3 during CNTF signaling is mediated by the Rapamycin target mTOR
- Mammalian target of Rapamycin: immunosuppressive drugs uncover a novel pathway of cytokine receptor signaling
- Rapamycin: a bone sparing immunosuppressant?
- Insulin-stimulated phosphorylation of lipin mediated by the mammalian target of Rapamycin
- Mechanism of action of Rapamycin: New insights into the regulation of G1-phase progression in eukaryotic cells
- Preclinical evaluation of a new potent immunosuppressive agent, Rapamycin.
- Early clinical experience with a novel Rapamycin derivative
- Antitumor activity of the Rapamycin analog CCI-779 in human primitive neuroectodermal tumor/medulloblastoma models as single agent and in combination …
- AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of Rapamycin (mTOR) signaling
- Total synthesis of Rapamycin and demethoxyRapamycin
- Rapamycin induces the G0 program of transcriptional repression in yeast by interfering with the TOR signaling pathway
- Identification of phosphorylation sites in the translational regulator, PHAS-I, that are controlled by insulin and Rapamycin in rat adipocytes
- Synergistic interactions of cyclosporine and Rapamycin to inhibit immune performances of normal human peripheral blood lymphocytes in vitro.
- Interaction between FKBP12-Rapamycin and TOR involves a conserved serine residue.
- Comparison of acute Rapamycin nephrotoxicity with cyclosporine and FK506
- Refined structure of the FKBP12–Rapamycin–FRB ternary complex at 2.2 Å resolution
- Immunosuppressants FK506 and Rapamycin function as reversal agents of the multidrug resistance phenotype
- Regulation of the cell integrity pathway by Rapamycin-sensitive TOR function in budding yeast
- Rapamycin, a potent immunosuppressive drug, causes programmed cell death in B lymphoma cells
- Sirolimus (Rapamycin) for the treatment of steroid-refractory acute graft-versus-host disease1
- Hyperlipidemia in renal transplant recipients treated with sirolimus (Rapamycin)
- Effects of Rapamycin on Ryanodine Receptor/Ca2+-Release Channels From Cardiac Muscle
- Conversion to Rapamycin immunosuppression in renal transplant recipients: report of an initial Experience1
- Global and specific translational control by Rapamycin in T cells uncovered by microarrays and proteomics
- Synergistic effects of cyclosporine and Rapamycin in a chronic nephrotoxicity model1
- Rapamycin inhibits constitutive p70s6k phosphorylation, cell proliferation, and colony formation in small cell lung cancer cells
- Total synthesis of (-)-Rapamycin using an Evans-Tishchenko fragment coupling
- FKBP12-Rapamycin-associated protein (FRAP) autophosphorylates at serine 2481 under translationally repressive conditions
- Rapamycin sensitivity in Saccharomyces cerevisiae is mediated by a peptidyl-prolyl cis-trans isomerase related to human FK506-binding protein.
- Rapamycin blocks cell cycle progression of activated T cells prior to events characteristic of the middle to late G1 phase of the cycle
- FKBP12-Rapamycin-associated protein associates with mitochondria and senses osmotic stress via mitochondrial dysfunction
- Modulation of transcription of rRNA genes by Rapamycin
- The effect of Rapamycin on kidney function in the Sprague-Dawley rat.
- Organization of the biosynthetic gene cluster for Rapamycin in Streptomyces hygroscopicus: analysis of the enzymatic domains in the modular polyketide synthase
- Growth-dependent translation of IGF-II mRNA by a Rapamycin-sensitive pathway
- Effects of Rapamycin in experimental organ allografting.
- Metabolic and autocrine regulation of the mammalian target of Rapamycin by pancreatic β-cells
- Predominant nuclear localization of mammalian target of Rapamycin in normal and malignant cells in culture
- Effect of nitrogen source on biosynthesis of Rapamycin by Streptomyces hygroscopicus
- Rapamycin‐sensitive phase of 3T3‐L1 preadipocyte differentiation after clonal expansion
- The mammalian target of Rapamycin phosphorylates sites having a (Ser/Thr)-Pro motif and is activated by antibodies to a region near its COOH terminus
- Rapamycin eluting stent: the onset of a new era in interventional cardiology
- Efficacy of sirolimus (Rapamycin) administered concomitantly with a subtherapeutic dose of cyclosporin in the treatment of severe psoriasis: a randomized controlled …
- B cell receptor-associated protein α4 displays Rapamycin-sensitive binding directly to the catalytic subunit of protein phosphatase 2A
- The immunosuppressant Rapamycin induces inactivation of p70s6k through dephosphorylation of a novel set of sites
- Regulation of translational effectors by amino acid and mammalian target of Rapamycin signaling pathways: possible involvement of autophagy in cultured …
- Molecular mechanisms of immunosuppression by cyclosporine, FK506, and Rapamycin.
- … vascular smooth muscle cell DNA synthesis. inhibition of basic fibroblast growth factor and platelet-derived growth factor action and antagonism of Rapamycin by …
- Mammalian target of Rapamycin pathway regulates insulin signaling via subcellular redistribution of insulin receptor substrate 1 and integrates nutritional signals and …
- Influence of cyclosporin, tacrolimus and Rapamycin on renal function and arterial hypertension after renal transplantation
- Antifungal activities of Rapamycin and its derivatives, prolylRapamycin, 32-desmethylRapamycin, and 32-desmethoxyRapamycin
- Rapamycin inhibits macropinocytosis and mannose receptor–mediated endocytosis by bone marrow–derived dendritic cells
- Pharmacokinetics of Rapamycin.
- The immunosuppressant Rapamycin represses human immunodeficiency virus type 1 replication
- Treatment with Rapamycin and mycophenolic acid reduces arterial intimal thickening produced by mechanical injury and allows endothelial replacement.
- Rapamycin inhibits arterial intimal thickening caused by both alloimmune and mechanical injury. Its effect on cellular, growth factor, and cytokine response in injured …
- Rapamycin reverses chronic graft vascular disease in a novel cardiac allograft model
- Total synthesis of Rapamycin via a novel titanium-mediated aldol macrocyclization reaction
- Cyclosporin A, FK-506, and Rapamycin: pharmacologic probes of lymphocyte signal transduction
- Enhancement of the antifungal activity of Rapamycin by the coproduced elaiophylin and nigericin
- … X-ray structures of the major binding protein for the immunosuppressant FK506 (tacrolimus) in unliganded form and in complex with FK506 and Rapamycin
- Mammalian target of Rapamycin-dependent phosphorylation of PHAS-I in four (S/T) P sites detected by phospho-specific antibodies
- Rapamycin induces apoptosis in monocyte-and CD34-derived dendritic cells but not in monocytes and macrophages
- Activation of mRNA translation in rat cardiac myocytes by insulin involves multiple Rapamycin-sensitive steps
- Clinical development of mammalian target of Rapamycin inhibitors
- Identification of an 11-kDa FKBP12-Rapamycin-binding domain within the 289-kDa FKBP12-Rapamycin-associated protein and characterization of a critical serine …
- COMBINED COSTIMULATION BLOCKADE PLUS Rapamycin BUT NOT CYCLOSPORINE PRODUCES PERMANENT ENGRAFTMENT1
- Effect of amino acids on Rapamycin biosynthesis by Streptomyces hygroscopicus
- Rapamycin antifungal action is mediated via conserved complexes with fkbp12 and tor kinase homologs incryptococcus neoformans
- Rapamycin-induced inhibition of p34cdc2 kinase activation is associated with G1/S-phase growth arrest in T lymphocytes.
- Dominant missense mutations in a novel yeast protein related to mammalian phosphatidylinositol 3-kinase and VPS34 abrogate Rapamycin cytotoxicity.
- … autophagy and activation of lysosome-dependent proteolysis in C2C12 myotubes through a mammalian target of Rapamycin-independent signaling pathway
- Control of PHAS-I by insulin in 3T3-L1 adipocytes: synthesis, degradation, and phosphorylation by a Rapamycin-sensitive and mitogen-activated protein …
- Stress-activated protein kinase-2/p38 and a Rapamycin-sensitive pathway are required for C2C12 myogenesis
- Rapamycin and less immunosuppressive analogs are toxic to Candida albicans and Cryptococcus neoformans via FKBP12-dependent inhibition of TOR
- Rapamycin (sirolimus, rapamune).
- Organisation of the biosynthetic gene cluster for Rapamycin in Streptomyces hygroscopicus: analysis of genes flanking the polyketide synthase
- Rapamycin selectively inhibits angiotensin II–induced increase in protein synthesis in cardiac myocytes in vitro: potential role of 70-kD S6 kinase in angiotensin II …
- Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of Rapamycin-dependent signaling pathway
- Resistance to Rapamycin: a novel anticancer drug
- Carbon source nutrition of Rapamycin biosynthesis in Streptomyces hygroscopicus
- Osteoblastic differentiation is enhanced by Rapamycin in rat osteoblast-like osteosarcoma (ROS 17/2.8) cells
- Regulation of an activated S6 kinase 1 variant reveals a novel mammalian target of Rapamycin phosphorylation site
- The Rapamycin analogue SDZ RAD attenuates bleomycin-induced pulmonary fibrosis in rats
- Regulation of translation elongation factor‐2 by insulin via a Rapamycin‐sensitive signalling pathway.
- The FKBP12‐Rapamycin‐associated protein (FRAP) is a CLIP‐170 kinase
- Rapamycin selectively inhibits the growth of childhood rhabdomyosarcoma cells through inhibition of signaling via the type I insulin-like growth factor receptor
- Molecular characterization of a plant FKBP12 that does not mediate action of FK506 and Rapamycin
- Synergistic effect of Rapamycin and cyclosporin A in the treatment of experimental autoimmune uveoretinitis.
- Rapamycin-insensitive regulation of 4e-BP1 in regenerating rat liver
- Tuberous sclerosis complex-1 and-2 gene products function together to inhibit mammalian target of Rapamycin (mTOR)-mediated downstream signaling
- Evidence that phosphorylation of human Upfl protein varies with intracellular location and is mediated by a wortmannin-sensitive and Rapamycin-sensitive PI 3-kinase …
- Failure of hormone therapy in prostate cancer involves systematic restoration of androgen responsive genes and activation of Rapamycin sensitive signaling
- Differential anti-inflammatory effects of immunosuppressive drugs: cyclosporin, Rapamycin and FK-506 on inducible nitric oxide synthase, nitric oxide, cyclooxygenase …
- cAMP-and Rapamycin-sensitive regulation of the association of eukaryotic initiation factor 4E and the translational regulator PHAS-I in aortic smooth muscle cells
- A Rapamycin-selective 25-kDa immunophilin
- FKBP12‐Rapamycin target TOR2 is a vacuolar protein with an associated phosphatidylinositol‐4 kinase activity.
- Pharmacokinetics and safety of single oral doses of sirolimus (Rapamycin) in healthy male volunteers
- Insulin stimulation of glycogen synthesis and glycogen synthase activity is blocked by wortmannin and Rapamycin in 3T3-L1 adipocytes: evidence for the involvement …
- The TOR (target of Rapamycin) signal transduction pathway regulates the stability of translation initiation factor eIF4G in the yeast Saccharomyces cerevisiae
- Heat capacity changes and hydrophobic interactions in the binding of FK506 and Rapamycin to the FK506 binding protein
- Attenuation of mammalian target of Rapamycin activity by increased cAMP in 3T3-L1 adipocytes
- Rapamycin specifically interferes with the developmental response of fission yeast to starvation.
- CD28 signaling causes a sustained down-regulation of I kappa B alpha which can be prevented by the immunosuppressant Rapamycin.
- Incorporation of acetate, propionate, and methionine into Rapamycin by Streptomyces hygroscopicus
- … Virus 1 Envelope Glycoprotein Complex-induced Apoptosis Involves Mammalian Target of Rapamycin/FKBP12-Rapamycin–associated Protein–mediated p53 …
- The efficacy and toxicity of Rapamycin in murine islet transplantation. In vitro and in vivo studies.
- Rapamycin partially prevents insulin resistance induced by chronic insulin treatment
- Rapamycin potentiates transforming growth factor β-induced growth arrest in nontransformed, oncogene-transformed, and human cancer cells
- Molecular mechanisms of action of new xenobiotic immunosuppressive drugs: tacrolimus (FK506), sirolimus (Rapamycin), mycophenolate mofetil and leflunomide
- Rapamycin-sensitive phosphorylation of PKC on a carboxy-terminal site by an atypical PKC complex
- Prolongation of renal allograft survival in a large animal model by oral Rapamycin monotherapy.
- The effect of a high‐fat meal on the oral bioavailability of the immunosuppressant sirolimus (Rapamycin)
- Intracellular sensing of amino acids in Xenopus laevis oocytes stimulates p70 S6 kinase in a target of Rapamycin-dependent manner
- SIROLIMUS (Rapamycin) HALTS AND REVERSES PROGRESSION OF ALLOGRAFT VASCULAR DISEASE IN NON-HUMAN PRIMATES1
- The isolation, synthesis and characterization of an isomeric form of Rapamycin
- Effects of cyclosporin, FK506, and Rapamycin on graft-vessel disease
- … translational control of GLUT1 and GLUT4 glucose transporter mRNAs in response to insulin: role of mammalian target of Rapamycin, protein kinase b, and …
- Rapamycin inhibition of interleukin-2-dependent p33cdk2 and p34cdc2 kinase activation in T lymphocytes.
- A Unified Total Synthesis of the Immunomodulators (−)-Rapamycin and (−)-27-DemethoxyRapamycin: Assembly of the Common C (1− 20) Perimeter and Final …
- Mechanism of the combination immunosuppressive effects of Rapamycin with either cyclosporine or tacrolimus
- The antimicrobial activities of cyclosporine, FK506, and Rapamycin
- Molecular cloning of a membrane-associated human FK506-and Rapamycin-binding protein, FKBP-13.
- Contrasting impacts of immunosuppressive agents (Rapamycin, FK506, cyclosporin A, and dexamethasone) on bidirectional dendritic cell-T cell interaction during …
- … new protein that forms specific complexes with both immunophilins FKBP59 and FKBP12: prevention by the immunosuppressant drugs FK506 and Rapamycin
- Cytochrome P-450 3A enzymes are responsible for biotransformation of FK506 and Rapamycin in man and rat.
- Rapamycin Inhibits α1-Adrenergic Receptor–Stimulated Cardiac Myocyte Hypertrophy but Not Activation of Hypertrophy-Associated Genes: Evidence for Involvement …
- FK506 and Rapamycin: novel pharmacological probes of the immune response
- Target of Rapamycin
- Mutagenesis of the Rapamycin producer Streptomyces hygroscopicus FC904
- The effect of Rapamycin on T cell development in mice
- The effects of Rapamycin in murine peripheral nerve isografts and allografts
- 4E-binding proteins, the suppressors of eukaryotic initiation factor 4E, are down-regulated in cells with acquired or intrinsic resistance to Rapamycin
- A putative sirolimus (Rapamycin) effector protein
- Rapamycin: In Vitro Profile of a New Immunosuppressive Macrolide.
- The Upregulation of p27Kip1 by Rapamycin Results in G1 Arrest in Exponentially Growing T-Cell Lines
- Generation of novel Rapamycin structures by microbial manipulations
- Consensus guidelines for therapeutic drug monitoring of Rapamycin: report of the consensus panel
- Comparative study of cyclosporine and tacrolimus vs newer immunosuppressants mycophenolate mofetil and Rapamycin on coronary endothelial function
- Convergence of the target of Rapamycin and the Snf1 protein kinase pathways in the regulation of the subcellular localization of Msn2, a transcriptional …
- FKBP-Rapamycin inhibits a cyclin-dependent kinase activity and a cyclin D1-Cdk association in early G1 of an osteosarcoma cell line.
- Neointimal formation after balloon-induced vascular injury in Yucatan minipigs is reduced by oral Rapamycin
- Insulin activates protein kinase B, inhibits glycogen synthase kinase-3 and activates glycogen synthase by Rapamycin-insensitive pathways in skeletal muscle …
- Roles of peptidyl-prolyl cis-trans isomerase and calcineurin in the mechanisms of antimalarial action of cyclosporin A, FK506, and Rapamycin
- Studies on the chemistry of Rapamycin: novel transformations under Lewis-acid catalysis
- Rapamycin on trial
- Effects of Rapamycin on cultured hepatocyte proliferation and gene expression
- Therapeutic monitoring of Rapamycin: a new immunosuppressive drug.
- Chlamydia trachomatis Mip‐like protein has peptidylprolyl cis/trans isomerase activity that is inhibited by FK506 and Rapamycin and is implicated in initiation of …
- MID1 and MID2 homo-and heterodimerise to tether the Rapamycin-sensitive PP2A regulatory subunit, alpha 4, to microtubules: implications for the clinical …
- Rapamycin (sirolimus) inhibits proliferating cell nuclear antigen expression and blocks cell cycle in the G1 phase in human keratinocyte stem cells.
- Rapamycin prevents the onset of insulin‐dependent diabetes mellitus (IDDM) in NOD mice
- Sensitive and specific quantification of sirolimus (Rapamycin) and its metabolites in blood of kidney graft recipients by HPLC/electrospray-mass spectrometry
- … LYMPHOCYTES MAY DISTINGUISH CYCLOSPORINE EFFECT IN RENAL TRANSPLANT RECIPIENTS RECEIVING A CYCLOSPORINE+ Rapamycin REGIMEN1
- Rapamycin, a potential disease-modifying antiarthritic drug.
- The insulin-induced signalling pathway leading to S6 and initiation factor 4E binding protein 1 phosphorylation bifurcates at a Rapamycin-sensitive point immediately …
- Myogenic differentiation is dependent on both the kinase function and the N-terminal sequence of mammalian target of Rapamycin
- Treatment of autoimmune uveoretinitis in the rat with Rapamycin, an inhibitor of lymphocyte growth factor signal transduction
- Rapamycin, a potent immunosuppressive drug for vascularized heart, kidney, and small bowel transplantation in the rat.
- lnterleukin-2-mediated elimination of the p27 Kipl cyclin-dependent kinase inhibitor prevented by Rapamycin
- Atomic structures of the human immunophilin FKBP-12 complexes with FK506 and Rapamycin
- Ultraviolet-induced phosphorylation of p70S6K at Thr389 and Thr421/Ser424 involves hydrogen peroxide and mammalian target of Rapamycin but not Akt and atypical …
- Toxicity of Rapamycin–a comparative and combination study with cyclosporine at immunotherapeutic dosage in the rat.
- L-Asparaginase inhibits the Rapamycin-targeted signaling pathway
- The Rapamycin and FKBP12 target (RAFT) displays phosphatidylinositol 4-kinase activity
- The Target of Rapamycin Signaling Pathway Regulates mRNA Turnover in the Yeast Saccharomyces cerevisiae
- Protein kinase activity and identification of a toxic effector domain of the target of Rapamycin TOR proteins in yeast
- inhibition of in vitro immunoglobulin production by Rapamycin.
- Rapamycin inhibits corneal allograft rejection and neovascularization
- Base catalyzed degradations of Rapamycin
- Rapamycin inhibits the generation of graft-versus-host disease-and graft-versus-leukemia-causing T cells by interfering with the production of Th1 or Th1 cytotoxic …
- The immunosuppressive macrolides FK-506 and Rapamycin act as reciprocal antagonists in murine T cells.
- Rapamycin: FK506’s fraternal twin or distant cousin?
- Substrate specificity for the human rotamase FKBP: a view of FK506 and Rapamycin as leucine-(twisted amide)-proline mimics
- Structure-activity studies of Rapamycin analogs: evidence that the C-7 methoxy group is part of the effector domain and positioned at the FKBP12-FRAP …
- Rapamycin reduces hybridoma cell death and enhances monoclonal antibody production
- A novel FK506-and Rapamycin-binding protein (FPR3 gene product) in the yeast Saccharomyces cerevisiae is a proline rotamase localized to the nucleolus.
- p70s6k integrates phosphatidylinositol 3-kinase and Rapamycin-regulated signals for E2F regulation in T lymphocytes
- DIFFERENTIAL EFFECTS OF CYCLOSPORINE A, METHYLPREDNISOLONE, MYCOPHENOLATE, AND Rapamycin ON CD154 INDUCTION AND REQUIREMENT …
- Target of Rapamycin proteins and their kinase activities are required for meiosis
- Rapamycin-FKBP12 blocks proliferation, induces differentiation, and inhibits cdc2 kinase activity in a myogenic cell line.
- inhibition by Rapamycin of PDGF-and bFGF-induced human tenon fibroblast proliferation in vitro.
- New process control strategy used in a Rapamycin fermentation
- Tacrolimus-Rapamycin combination therapy for experimental autoimmune uveoretinitis
- Serotonin Activates S6 Kinase in a Rapamycin-Sensitive Manner inAplysia Synaptosomes
- A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of Rapamycin in mitogen-stimulated and transformed cells
- Insulin regulates lipoprotein lipase activity in rat adipose cells via wortmannin-and Rapamycin-sensitive pathways
- Phosphate, ammonium, magnesium and iron nutrition of Streptomyces hygroscopicus with respect to Rapamycin biosynthesis
- Constitutive activation of S6 kinase by deletion of amino-terminal autoinhibitory and Rapamycin sensitivity domains.
- Growth of Streptomyces hygroscopicus in rotating-wall bioreactor under simulated microgravity inhibits Rapamycin production
- Structure of Rapamycin: an NMR and molecular‐dynamics investigation
- 40-O-(2-Hydroxyethyl)-Rapamycin Attenuates Pulmonary Arterial Hypertension and Neointimal Formation in Rats
- The Drosophila p70s6k homolog exhibits conserved regulatory elements and Rapamycin sensitivity
- Structure-activity studies of nonmacrocyclic Rapamycin derivatives
- Gene disruption and replacement in the Rapamycin-producing Streptomyces hygroscopicus strain ATCC 29253
- Production of synergistic but nonidentical mechanisms of immunosuppression by Rapamycin and cyclosporine.
- A Unified Total Synthesis of the Immunomodulators (−)-Rapamycin and (−)-27-DemethoxyRapamycin: Construction of the C (21− 42) Perimeters
- Design and Synthesis of a Rapamycin-based high affinity binding FKBP12 ligand
- Synthetic investigations of Rapamycin. 2. Synthesis of a C (22)-C (42) fragment
- The immunosuppressant Rapamycin, alone or with transforming growth factor-b, enhances osteoclast differentiation of RAW264. 7 monocyte-macrophage cells in the …
- Origin and true nature of the starter unit for the Rapamycin polyketide synthase
- … , p70 S6 kinase and glycogen synthase kinase-3 activity in L6 muscle cells: evidence for the involvement of the mammalian target of Rapamycin (mTOR) pathway in the …
- Impaired phosphate handling of renal allografts is aggravated under Rapamycin‐based immunosuppression
- … in stereochemical communication: a strategy for the stereospecific synthesis and stabilization of the triene substructure of Rapamycin through sulfone substitution
- TACROLIMUS (FK506) AND SIROLIMUS (Rapamycin) IN COMBINATION ARE NOT ANTAGONISTIC BUT PRODUCE EXTENDED GRAFT SURVIVAL IN CARDIAC …
- Distinct mechanisms of suppression of murine T cell activation by the related macrolides FK-506 and Rapamycin.
- Raf/MAPK and Rapamycin-sensitive pathways mediate the anti-apoptotic function of p21Ras in IL-3-dependent hematopoietic cells
- Rapamycin INDUCES TRANSFORMING GROWTH FACTOR-β PRODUCTION BY LYMPHOCYTES1
- Insulin release and suppression by tacrolimus, Rapamycin and cyclosporin A are through regulation of the ATP‐sensitive potassium channel
- … kinase-3 by insulin or insulin-like growth factor 1 in the rat skeletal muscle cell line L6 is blocked by wortmannin, but not by Rapamycin: evidence that wortmannin …
- The Pipecolate‐Incorporating Enzyme for the Biosynthesis of the Immunosuppressant Rapamycin—Nucleotide Sequence Analysis, Disruption and Heterologous …
- Graft-versus-host disease prevention by Rapamycin: cellular mechanisms
- Regulation of both glycogen synthase and PHAS-I by insulin in rat skeletal muscle involves mitogen-activated protein kinase-independent and Rapamycin …
- Quantitative analysis of sirolimus (Rapamycin) in blood by high-performance liquid chromatography–electrospray tandem mass spectrometry
- Potentiation of glucocorticoid receptor-mediated gene expression by the immunophilin ligands FK506 and Rapamycin.
- Isolation of two immunosuppressive metabolites after in vitro metabolism of Rapamycin.
- p-Glycoprotein-mediated transport of a fluorescent Rapamycin derivative in renal proximal tubule
- Expression, enzyme activity, and subcellular localization of mammalian target of Rapamycin in insulin-responsive cells
- Insulin regulation of glucose-6-phosphate dehydrogenase gene expression is Rapamycin-sensitive and requires phosphatidylinositol 3-kinase
- Rapamycin blocks IL-2-driven T cell cycle progression while preserving T cell survival
- Molecular cloning of a 25-kDa high affinity Rapamycin binding protein, FKBP25.
- The immediate precursor of the nitrogen-containing ring of Rapamycin is free pipecolic acid
- Cholestasis and regulation of genes related to drug metabolism and biliary transport in rat liver following treatment with cyclosporine A and sirolimus (Rapamycin)
- A novel ring contraction of Rapamycin
- Prolongation of canine pancreatic islet allograft survival with combined Rapamycin and cyclosporine therapy at low doses. Rapamycin efficacy is blood level related.
- inhibition of liver, kidney, and intestine regeneration by Rapamycin
- Ig receptor binding protein 1 (α4) is associated with a Rapamycin-sensitive signal transduction in lymphocytes through direct binding to the catalytic subunit of protein …
- … of the International Society for Heart and Lung Transplantation working formulation for heart transplant biopsy specimens. Rapamycin Cardiac Rejection Treatment …
- Effect of Rapamycin on the cyclosporin A–resistant CD28-mediated costimulatory pathway
- Lack of change of cancellous bone volume with short-term use of the new immunosuppressant Rapamycin in rats
- Studies towards the total synthesis of Rapamycin: A convergent and stereoselective synthesis of the C22 C32 carbon framework
- Rapamycin and wortmannin enhance replication of a defective encephalomyocarditis virus
- … factor and its transcriptional activator, hypoxia inducible factor-1α, through a pathway involving phosphoinositide 3-kinase and the mammalian target of Rapamycin
- … acid-induced translation of TOP mRNAs is fully dependent on phosphatidylinositol 3-kinase-mediated signaling, is partially inhibited by Rapamycin, and is independent …
- Effect of p27 deficiency and Rapamycin on intimal hyperplasia: in vivo and in vitro studies using a p27 knockout mouse model
- The effect of dexamethasone, cyclosporine, and Rapamycin on T-lymphocyte proliferation in vitro: comparison of cells from patients with glucocorticoid-sensitive and …
- Rapamycin increases the cellular concentration of the BCL-2 protein and exerts an anti-apoptotic effect
- Complete amino acid sequence of the FK506 and Rapamycin binding protein, FKBP, isolated from calf thymus
- Effects of Rapamycin, cyclosporin A, and dexamethasone on interleukin 5‐induced eosinophil degranulation and prolonged survival
- Microbial conversion of Rapamycin
- Therapeutic blood levels of sirolimus (Rapamycin) in the allografted rat
- Effect of Rapamycin on the expression of the IL‐2 receptor (CD25)
- Rapamycin inhibits transplant vasculopathy in long-surviving rat heart allografts.
- β-Agonists regulate Na, K-ATPase via novel MAPK/ERK and Rapamycin-sensitive pathways
- Assessment of cell‐signaling pathways in the regulation of mammalian target of Rapamycin (mTOR) by amino acids in rat adipocytes
- Beneficial effects of cyclosporine and Rapamycin in small bowel ischemic injury
- Routine clinical monitoring of sirolimus (Rapamycin) whole-blood concentrations by HPLC with ultraviolet detection
- inhibition by Rapamycin of P‐glycoprotein 170‐mediated export from normal lymphocytes
- Sample clean-up and high-performance liquid chromatographic techniques for measurement of whole blood Rapamycin concentrations
- THE METABOLIC IMPACT OF Rapamycin (SIROLIMUS) IN CHRONIC CANINE ISLET GRAFT RECIPIENTS1
- Rapamycin inhibits ribosomal protein synthesis and induces G1 prolongation in mitogen-activated T lymphocytes.
- Dominant mutations confer resistance to the immunosuppressant, Rapamycin, in variants of a T cell lymphoma
- Effects of cyclosporine and Rapamycin on immunoglobulin production by preactivated human B cells
- Facile synthesis of the “tricarbonyl” subunit in the immunosuppressant Rapamycin
- Effects of FK506 and Rapamycin on excitation‐contraction coupling in skeletal muscle fibres of the rat.
- Involvement of a Rapamycin-sensitive pathway in CD40-mediated activation of murine B cells in vitro
- Degradation of Rapamycin: synthesis of a Rapamycin derived fragment containing the tricarbonyl and triene sectors
- Calcineurin inhibitor‐induced chronic nephrotoxicity in liver transplant patients is reversible using Rapamycin as the primary immunosuppressive agent
- EFFECT OF TACROLIMUS (FK506) AND SIROLIMUS (Rapamycin) MONO-AND COMBINATION THERAPY IN PROLONGATION OF RENAL ALLOGRAFT …
- Efficacy of Rapamycin and FK 506 in prolonging rat hind limb allograft survival.
- Distinct repression of translation by wortmannin and Rapamycin
- Evidence that Rapamycin inhibits interleukin-12-induced proliferation of activated T lymphocytes.
- Determination of Rapamycin in whole blood by HPLC
- Total synthesis of Rapamycin
- Rapamycin inhibits p34cdc2 expression and arrests T lymphocyte proliferation at the G1/S transition.
- Uncoupling p70s6 kinase activation and proliferation: Rapamycin-resistant proliferation of human CD8+ T lymphocytes
- Exogenous shikimic acid stimulates Rapamycin biosynthesis inStreptomyces hygroscopicus
- Ryanodine receptors from rabbit skeletal muscle are reversibly activated by Rapamycin
- Synthetic studies toward Rapamycin: a solution to a problem in chirality merger through use of the Ireland reaction
- The nature of the starter unit for the Rapamycin polyketide synthase
- Invasive aspergillosis in mice immunosuppressed with cyclosporin A, tacrolimus (FK506), or sirolimus (Rapamycin)
- Proinflammatory effects in experimental mesangial proliferative glomerulonephritis of the immunosuppressive agent SDZ RAD, a Rapamycin derivative
- USE OF ANTI-CD25 MONOCLONAL ANTIBODY IN COMBINATION WITH Rapamycin TO ELIMINATE CYCLOSPORINE TREATMENT DURING THE INDUCTION …
- Loss of ypk1 function causes Rapamycin sensitivity, inhibition of translation initiation and synthetic lethality in 14-3-3-deficient yeast
- Acute effects of Rapamycin on glomerular dynamics: a micropuncture study in the rat
- Cyclosporine, FK506, and Rapamycin. Some effects on early activation events in serum-free, mitogen-stimulated mouse spleen cells.
- The cyclohexane moiety of Rapamycin is derived from shikimic acid in Streptomyces hygroscopicus
- Murine recipients of fully mismatched donor marrow are protected from lethal graft-versus-host disease by the in vivo administration of Rapamycin but develop an …
- In vitro and in situ absorption of SDZ-RAD using a human intestinal cell line (Caco-2) and a single pass perfusion model in rats: comparison with Rapamycin
- Degradative studies on the tricarbonyl containing macrolide Rapamycin
- The potential role of Rapamycin in pediatric transplantation as observed from adult studies
- Comparison of the effects of FK-506, cyclosporin A and Rapamycin on IL-2 production.
- Insulin-stimulated kinase from rat fat cells that phosphorylates initiation factor 4E-binding protein 1 on the Rapamycin-insensitive site (serine-111)
- The immunosuppressive and toxic effects of FK-506 are mechanistically related: pharmacology of a novel antagonist of FK-506 and Rapamycin.
- Rapamycin and p53 act on different pathways to induce G1 arrest in mammalian cells
- Effect of Rapamycin on rat aortic ring vasomotion.
- … cycle protein expression in vascular smooth muscle cells in vitro and in vivo is regulated through phosphatidylinositol 3-kinase and mammalian target of Rapamycin
- Rapamycin blocks sexual development in fission yeast through inhibition of the cellular function of an FKBP12 homolog
- Simultaneous on-line extraction and analysis of sirolimus (Rapamycin) and ciclosporin in blood by liquid chromatography–electrospray mass spectrometry
- Both Rapamycin-sensitive and-insensitive pathways are involved in the phosphorylation of the initiation factor-4E-binding protein (4E-BP1) in response to insulin in rat …
- Compared to mycophenolate mofetil, Rapamycin induces significant changes on growth factors and growth factor receptors in the early days postkidney …
- Mammalian RAFT1 kinase domain provides Rapamycin-sensitive TOR function in yeast.
- Conversion from liquid to solid Rapamycin formulations in stable renal allograft transplant recipients
- Secretion of FK506/FK520 and Rapamycin by Streptomyces inhibits the growth of competing Saccharomyces cerevisiae and Cryptococcus neoformans
- Side effects of Rapamycin in the rat
- The effect of Rapamycin on single ENaC channel activity and phosphorylation in A6 cells
- Rapamycin (Sirolimus) inhibits vascular smooth muscle DNA synthesis in vitro and suppresses narrowing in arterial allografts and in balloon-injured carotid arteries …
- Measurement of Rapamycin in whole blood using reverse-phase high-performance liquid chromatography.
- Regulation of the Rapamycin and FKBP-target 1/mammalian target of Rapamycin and cap-dependent initiation of translation by the c-Abl protein-tyrosine kinase
- Rapamycin stimulates viral protein synthesis and augments the shutoff of host protein synthesis upon picornavirus infection.
- Two discrete regions of interleukin-2 (IL2) receptor β independently mediate IL2 activation of a PD98059/Rapamycin/wortmannin-insensitive Stat5a/b serine …
- The tyrosine89 residue of yeast FKBP12 is required for Rapamycin binding
- Assignment of the human FKBP12-Rapamycin-associated protein (FRAP) gene to chromosome 1p36 by fluorescence in situ hybridization
- Rapamycin, but not FK506 and GPI-1046, increases neurite outgrowth in PC12 cells by inhibiting cell cycle progression
- Rapamycin: personal algorithms for use based on 250 treated renal allograft recipients.
- Rapamycin INHIBITS DEVELOPMENT OF OBLITERATIVE AIRWAY DISEASE IN A MURINE HETEROTOPIC AIRWAY TRANSPLANT MODEL1
- The immunosuppressant Rapamycin blocks in vitro responses to hematopoietic cytokines and inhibits recovering but not steady-state hematopoiesis in vivo
- Estrogen and Rapamycin effects on cell cycle progression in T47D breast cancer cells
- The effects of the immunosuppressant Rapamycin on the growth of rheumatoid arthritis (RA) synovial fibroblast
- Deletion of rapQONML from the Rapamycin gene cluster of Streptomyces hygroscopicus gives production of the 16-O-desmethyl-27-desmethoxy analog
- Rapamycin may prevent post-transplant lymphoma
- … π-face selectivity in anti aldol reactions of E-enol borinates from chiral alkoxymethyl ketones: stereocontrolled synthesis of a C24-C32 polyol subunit of Rapamycin
- … of MAP kinases, pp90rsk and pp70‐S6 kinases in mouse mast cells by signaling through the c‐kit receptor tyrosine kinase or FcϵRI: Rapamycin inhibits activation of …
- Intramolecular hydrogen transfer reactions of o-(bromophenyl) dialkylsilyl ethers. Preparation of Rapamycin-d1
- … 3-kinase, protein kinase B, and p70 S6 kinases in lipopolysaccharide-stimulated Raw 264.7 cells: differential effects of Rapamycin, Ly294002, and wortmannin on …
- Rapamycin dissociates p70S6K activation from DNA synthesis stimulated by bombesin and insulin in Swiss 3T3 cells
- Rapamycin inhibits the phosphorylation of p70 S6 kinase in IL-2 and mitogen-activated human T cells
- Rapamycin: immunosuppression, hyporesponsiveness, and side effects in a porcine renal allograft model.
- Effect of cyclosporine, mycophenolic acid, and Rapamycin on the proliferation of rat aortic vascular smooth muscle cells: in vitro study
- Single-channel activity of the Ca2+-dependent K+ channel is modulated by FK506 and Rapamycin
- Use of Rapamycin for the suppression of alloimmune reactions in vivo: schedule dependence, tolerance induction, synergy with cyclosporine and FK 506, and effect on …
- Failure of Rapamycin to block proliferation once resting cells have entered the cell cycle despite inactivation of p70 S6 kinase
- Rapamycin inhibits proteasome activator expression and proteasome activity
- ASSOCIATION OF GLUCOCORTICOIDS AND CYCLOSPORIN A OR Rapamycin PREVENTS E-SELECTIN AND IL-8 EXPRESSION DURING LPS-AND TNFα …
- The zinc finger protein GLI induces cellular sensitivity to the mTOR inhibitor Rapamycin
- Sirolimus (Rapamycin) in clinical transplantation
- Rapamycin inhibits didemnin B‐induced apoptosis in human HL‐60 cells: Evidence for the possible involvement of FK506‐binding protein 25
- Siloxanes: versatile templates for acyclic stereocontrol. Synthesis of the C27-C33 segment of Rapamycin
- Dose-dependent pharmacokinetics of Rapamycin-28-N,N-dimethylglycinate in the mouse
- Interstitial pneumonitis associated with sirolimus (Rapamycin) therapy after liver transplantation
- The relationship of blood concentrations of Rapamycin and cyclosporine to suppression of allograft rejection in a rabbit heterotopic heart transplant model.
- … -severe combined immunodeficient (HuPBL-SCID) mouse/skin allograft model is T cell mediated and inhibited by a combination of cyclosporine and Rapamycin
- … hydration contributions to the thermodynamics of ligand binding by proteins. Enthalpy and heat capacity changes of tacrolimus and Rapamycin binding to FK506 …
- Selective epimerization of Rapamycin via a retroaldol/aldol mechanism mediated by titanium tetraisopropoxide
- inhibition of proliferation but not erythroid differentiation of J2E cells by Rapamycin
- The 14-3-3 proteins positively regulate Rapamycin-sensitive signaling
- Systemic toxicity following administration of sirolimus (formerly Rapamycin) for psoriasis: association of capillary leak syndrome with apoptosis of lesional lymphocytes
- Oral administration of Rapamycin and cyclosporine differentially alter intestinal function in rabbits
- p70 S6 kinase sensitivity to Rapamycin is eliminated by amino acid substitution of Thr229.
- High‐Sensitivity sequencing of large proteins: Partial structure of the Rapamycin‐fkbp12 target
- Renal effects of Rapamycin in the spontaneously hypertensive rat
- Effects of immunosuppressants FK506 and Rapamycin on the heterooligomeric form of the progesterone receptor
- Sirolimus (Rapamycin, Rapamune®) and combination therapy with cyclosporin A in the rat developing adjuvant arthritis model: correlation with blood levels and the …
- The effect of Rapamycin on renal function in the rat: a comparative study with cyclosporine
- Efficient Removal of Pipecolinate from Rapamycin and FK506 by Reaction with n-Bu4N+ CN−
- Rapamycin resistance in ataxia-telangiectasia.
- Regulation of ribosomal S6 kinase 2 by mammalian target of Rapamycin
- Induction of differentiation of human myeloid leukemia cells by immunosuppressant macrolides (Rapamycin and FK506) and calcium/calmodulin-dependent kinase …
- Lipophilic benzamide and anilide derivatives as high-performance liquid chromatography internal standards: application to sirolimus (Rapamycin) determination
- Selective inhibitor of Janus tyrosine kinase 3, PNU156804, prolongs allograft survival and acts synergistically with cyclosporine but additively with Rapamycin
- … by insulin and insulin-like growth factor-I: glycogen synthase activation is antagonized by wortmannin or LY294002 but not by Rapamycin or by inhibiting …
- Pharmacokinetics of Rapamycin: single-dose studies in the rabbit.
- Preferential production of Rapamycin vs prolylRapamycin by Streptomyces hygroscopicus
- Successful myoblast allotransplantation in mdx mice using Rapamycin
- A second type-I PKS gene cluster isolated from Streptomyces hygroscopicus ATCC 29253, a Rapamycin-producing strain
- Pediatric utilization of Rapamycin for severe cardiac allograft rejection
- An application of the suárez reaction to the regiospecific and stereospecific synthesis of the C28-C42 segment of Rapamycin
- Immunopharmacology of Rapamycin
- Manipulation of the Rapamycin effector domain. selective nucleophilic substitution of the C7 methoxy group
- High performance liquid chromatographic isolation, spectroscopic characterization, and immunosuppressive activities of two Rapamycin degradation products
- Antifungal Rapamycin analogues with reduced immunosuppressive activity
- … localization of the human α4/IGBP1 gene, the structure of which is closely related to the yeast TAP42 protein of the Rapamycin-sensitive signal transduction pathway
- Antagonistic roles for CTLA-4 and the mammalian target of Rapamycin in the regulation of clonal anergy: enhanced cell cycle progression promotes recall antigen …
- inhibition by Rapamycin of ornithine decarboxylase and epithelial cell proliferation in intestinal IEC‐6 cells in culture
- Insulin stimulation of muscle protein synthesis in obese Zucker rats is not via a Rapamycin-sensitive pathway
- Stability of sirolimus (Rapamycin) in whole blood
- Automated simultaneous quantification of the immunosuppressants 40-O-(2-hydroxyethyl)Rapamycin and cyclosporine in blood with electrospray-mass spectrometric …
- Cytokine and alloantibody networks in long term cardiac allografts in rat recipients treated with Rapamycin.
- FK506 and Rapamycin modulate the functional activities of human peripheral blood eosinophils
- Sirolimus (Rapamycin) potentiates cyclosporine in prevention of acute lung rejection
- Rapamycin potentiates dexamethasone-induced apoptosis and inhibits JNK activity in lymphoblastoid cells
- FAP1, a homologue of human transcription factor NF‐X1, competes with Rapamycin for binding to FKBP12 in yeast
- Rapamycin destabilizes interleukin-3 mRNA in autocrine tumor cells by a mechanism requiring an intact 3’untranslated region.
- Effect of Rapamycin on morphological and functional parameters in the kidney of the rabbit
- Synthetic investigations of Rapamycin. 1. Synthesis of a C10-C21 fragment
- Suppression of acute rejection in allogeneic rat lung transplantation: a study of the efficacy and pharmacokinetics of Rapamycin derivative (SDZ RAD) used alone and …
- Proton and nitrogen sequential assignments and secondary structure determination of the human FK506 and Rapamycin binding protein
- Abrogation by Rapamycin of accelerated rejection in sensitized rats by inhibition of alloantibody responses and selective suppression of intragraft mononuclear and …
- FK506 binding protein 12 mediates sensitivity to both FK506 and Rapamycin in murine mast cells
- Post-translational reduction of cell surface expression of insulin receptors by cyclosporin A, FK506 and Rapamycin in bovine adrenal chromaffin cells
- Antiproliferative effect of Rapamycin on growth factor-stimulated human adult lung fibroblasts in vitro may explain its superior efficacy for prevention and treatment of …
- Effects of the combination of Rapamycin with tacrolimus or cyclosporin on experimental intimal hyperplasia
- Anisomycin and Rapamycin define an area upstream of p70/85S6k containing a bifurcation to histone H3-HMG-like protein phosphorylation and c-fos-c-jun induction.
- Rapamycin inhibits production of cytotoxic but not noncytotoxic antibodies and preferentially activates T helper 2 cells that mediate long-term survival of heart …
- Studies towards the total synthesis of Rapamycin: Preparation of the C10 C17 carbon unit
- Effects of Rapamycin on apoptosis of rheumatoid synovial cells
- Rapamycin and T cell costimulatory blockade as post-transplant treatment promote fully MHC-mismatched allogeneic bone marrow engraftment under …
- Mean field analysis of FKBP12 complexes with FK506 and Rapamycin: Implications for a role of crystallographic water molecules in molecular recognition and …
- Effects of immunosuppressive peptidyl-prolyl cis-trans isomerase (PPIase) inhibitors, cyclosporin A, FK506, ascomycin and Rapamycin, on hair growth initiation in …
- High performance liquid chromatographic isolation and spectroscopic characterization of three major metabolites from the plasma of rats receiving Rapamycin …
- Implication of alpha4 phosphoprotein and the Rapamycin-sensitive mammalian target-of-Rapamycin pathway in prolactin receptor signalling
- Effects of Rapamycin on human HLA-unrestricted cell killing
- cDNA Cloning of a human 5 kDa FK506 and Rapamycin binding protein
- Identification of a new metabolite of macrolide immunosuppressant, like Rapamycin and SDZ RAD, using high performance liquid chromatography and electrospray …
- Evidence that Rapamycin has differential effects of IL-4 function. Multiple IL-4 signaling pathways and implications for in vivo use.
- Calcium/calmodulin kinase inhibitors and immunosuppressant macrolides Rapamycin and FK506 inhibit progestin-and glucocorticosteroid receptor-mediated …
- CsA, FK506, corticosteroids and Rapamycin inhibit TNFα production by cultured PTEC
- Augmentation of SR Ca2+ release by Rapamycin and FK506 causes K+‐channel activation and membrane hyperpolarization in bladder smooth muscle
- Dihydroxylation of the triene subunit of Rapamycin
- Rituximab and Rapamycin for posttransplant lymphoproliferative disease treatment: report of three cases
- Effect of single-dose Rapamycin-based immunosuppression on the development of cardiac allograft vasculopathy.
- Rapamycin, FK506 and cyclosporin A inhibit human prolactin gene expression
- The immunomodulatory drugs cyclosporin A, mycophenolate mofetil, and sirolimus (Rapamycin) inhibit allergen-induced proliferation and IL-5 production by PBMCs …
- Rapamycin selectively blocks interleukin-2-induced proliferating cell nuclear antigen gene expression in T lymphocyte: evidence for inhibition of CREB/ATF …
- Rapamycin treatment depresses intragraft expression of KC/MIP-2, granzyme B, and IFN-gamma in rat recipients of cardiac allografts.
- Reversal of ongoing heart, kidney, and pancreas allograft rejection and suppression of accelerated heart allograft rejection in the rat by Rapamycin.
- Glucocorticoid-induced insulin resistance of protein synthesis is independent of the Rapamycin-sensitive pathways in rat skeletal muscle
- Long-term in vivo effects of Rapamycin on humoral and cellular immune responses in the rat
- … signals that control cell proliferation in mammalian balance epithelia: key roles for phosphatidylinositol-3 kinase, mammalian target of Rapamycin, and S6 kinases in …
- Rapamycin, a potent inhibitor of T-cell function, prevents graft rejection in murine recipients of allogeneic T-cell-depleted donor marrow [published erratum appears in …
- Immunosuppressant Rapamycin inhibits protein kinase C α and p38 mitogen-activated protein kinase leading to the inhibition of chondrogenesis
- FK506 and Rapamycin selectively enhance degradation of IL-2 and GM-CSF mRNA.
- THE IMMUNOSUPPRESSIVE EFFECT OF Rapamycin ON MOUSE SMALL BOWEL TRANSPLANTATION1
- Studies on selective reductions of Rapamycin
- Rapamycin: biological and therapeutic effects, binding by immunophilins and molecular targets of action
- PHARMACOKINETICS AND TOLERABILITY OF 40–0-[2-HYDROXYETHYL] Rapamycin IN DE NOVO LIVER TRANSPLANT RECIPIENTS1
- The synergistic interactions in vitro and in vivo of brequinar sodium with cyclosporine or Rapamycin alone and in triple combination.
- The future role of target of Rapamycin inhibitors in renal transplantation
- Rapamycin-induced long-term allograft survival depends on persistence of alloantigen.
- Effects of Rapamycin on renal hemodynamics, water and sodium excretion, and plasma levels of angiotensin II, aldosterone, atrial natriuretic peptide, and vasopressin …
- Structural identification of three metabolites and a degradation product of the macrolide immunosuppressant sirolimus (Rapamycin) by electrospray-MS/MS after …
- Interleukin 2 stimulation of p70 S6 kinase activity is inhibited by the immunosuppressant Rapamycin.
- Comparison of the effect of Rapamycin and FK506 on release of prostacyclin and endothelin in vitro
- A nonimmunosuppressive triene-modified Rapamycin analog is a potent inhibitor of peptidyl prolyl cis-trans-isomerase
- Cleavage of the cyclohexyl-subunit of Rapamycin results in loss of immunosuppressive activity
- A high performance liquid chromatographic method for the determination of Rapamycin (sirolimus) in rat serum, plasma, and blood and in monkey serum
- Cyclosporin A, FK506, Rapamycin: the use of a quantitative analytic tool to discriminate immunosuppressive drug interactions.
- Quantitative comparison of Rapamycin and cyclosporine effects on cytokine gene expression studied by reverse transcriptase-competitive polymerase chain reaction.
- Methionine Interference in Rapamycin Production Involves Repression of DemethylRapamycin Methyltransferase andS-Adenosylmethionine Synthetase
- A highly convergent strategy towards Rapamycin. Stereoselective construction of the C 8–C 18 fragment
- FK506 and Rapamycin binding to FKBP: Common elements in immunophilin-ligand complexation
- Cloning and sequence analysis of a Rapamycin-binding protein-encoding gene (RBP1) from Candida albicans
- Functional and histopathologic effects of Rapamycin on mouse kidney
- Reversal of multidrug resistance in Chinese hamster ovary cells by the immunosuppressive agent Rapamycin
- Structural basis for peptidomimicry by the effector element of Rapamycin
- Involvement of the Rapamycin-sensitive pathway in the insulin regulation of muscle protein synthesis in streptozotocin-diabetic rats
- COADMINISTRATION OF NEORAL AND THE NOVEL Rapamycin ANALOG, SDZ RAD, TO RAT LUNG ALLOGRAFT RECIPIENTS: Potentiation of …
- Efficacies of sirolimus (Rapamycin) and cyclosporine in allograft vascular disease in non-human primates: trough levels of sirolimus correlate with inhibition of …
- ADJUNCTIVE Rapamycin AND CsA TREATMENT INHIBITS MONOCYTE/MACROPHAGE ASSOCIATED CYTOKINES/CHEMOKINES IN SENSITIZED CARDIAC …
- Rapamycin (sirolimus) inhibits heart cell growth in vitro
- Rapamycin‐resistant phosphorylation of the initiation factor‐4E‐binding protein (4E‐BP1) in v‐SRC‐transformed hamster fibroblasts
- Acid catalyzed functionalization of Rapamycin
- Discordant effects of Rapamycin on proliferation and p70S6 kinase phosphorylation in normal and neoplastic rat chromaffin cells
- Missense mutations at the FKBP12-Rapamycin-binding site of TOR1
- Nutritional and intestinal effects of the novel immunosuppressive agents: deoxyspergualin, Rapamycin, and mycophenolate mofetil
- Rapamycin inhibits protein kinase C activity and stimulates Na+ transport in A6 cells
- inhibition by Rapamycin of leukocyte migration and bronchial hyperreactivity induced by injection of Sephadex beads to guinea‐pigs
- The RB/p107/p130 phosphorylation pathway is not inhibited in Rapamycin-induced G1-prolongation of NIH3T3 cells.
- The mechanism of unresponsiveness to allografts induced by Rapamycin and Rapamycin/cyclosporine treatment in rats.
- Calorimetric measurements of the complexation of cyclosporin A, ascomycin, fujimycin, and Rapamycin with lithium chloride and with an immunophilin
- ANALYSIS OF FUNCTIONAL RENAL ALLOGRAFT TOLERANCE WITH SINGLE-DOSE Rapamycin BASED INDUCTION IMMUNOSUPPRESSION1
- Genetic relationships among actinomycetes that produce the immunosuppressant macrolides FK506, FK520/FK523 and Rapamycin
- Rapamycin inhibits IL-1-mediated interferon-gamma production in the YAC-1 T cell lymphoma
- Rapamycin inhibits airway leukocyte infiltration and hyperreactivity in guinea pigs
- Synthetic approaches to Rapamycin
- Synthesis of the Tricarbonyl Subunit (C8−C19) of Rapamycin via Tandem Chan Rearrangement−Oxidation
- Rapamycin synthetic studies. 2. Elaboration of the C (10)-C (26) perimeter
- Use of Rapamycin in a transplant patient who developed cyclosporin neurotoxicity
- Prolactin and insulin synergize to regulate the translation modulator PHAS-I via mitogen-activated protein kinase-independent but wortmannin-and Rapamycin …
- Manipulation of the C (22)-C (27) region of Rapamycin: stability issues and biological implications
- Opposing effects of Rapamycin and cyclosporin A on activation-induced Ca2+ release
- Detection of noncovalent FKBP-FK506 and FKBP-Rapamycin complexes by capillary electrophoresis-mass spectrometry and capillary electrophoresis-tandem mass …
- Comparative effects of Rapamycin FK 506 and cyclosporine on antibody production, lymphocyte populations and immunoglobulin isotype switching in the rat
- Rapamycin insensitivity in Schistosoma mansoni is not due to FKBP12 functionality
- Lipase mediated hydrolysis of Rapamycin 42-hemisuccinate benzyl and methyl esters
- The effect of the immunophilin ligands Rapamycin and FK506 on proliferation of mast cells and other hematopoietic cell lines.
- Rapamycin: A new and highly active immunosuppressive macrolide with an efficacy superior to cyclosporine
- Effect of a short course of Rapamycin, cyclosporin A, and donor-specific transfusion on rat cardiac allograft survival.
- Cyclosporin A, FK506 and Rapamycin produce multiple, temporally distinct, effects on memory following single-trial, passive avoidance training in the chick
- Effect of Rapamycin on renal allograft survival in canine recipients treated with antilymphocyte serum, donor bone marrow, and cyclosporine.
- Synthesis of I‐125 labeled photoaffinity Rapamycin analogs
- Interleukin 4-inducible phosphorylation of HMG-I (Y) is inhibited by Rapamycin
- inhibition of CTL induction by Rapamycin: IL-2 rescues granzyme B and perforin expression but only partially restores cytotoxic activity.
- Effects of cyclosporin A, Rapamycin, and FK520 on peripheral T-cell deletion and anergy
- The effect of cyclosporin A, FK506 and Rapamycin on the murine contact sensitivity reaction
- Structure of FKBP12. 6 in complex with Rapamycin
- SUPERIORITY OF SIROLIMUS (Rapamycin) OVER CYCLOSPORINE IN AUGMENTING ALLOGRAFT AND XENOGRAFT SURVIVAL IN MICE TREATED WITH …
- Rapamycin but not FK506 inhibits the proliferation of mononuclear phagocytes induced by colony-stimulating factors
- inhibition of host-versus-graft and graft-versus-host responses after small bowel transplantation in rats by Rapamycin.
- Rapamycin and FK506 differentially inhibit mast cell cytokine production and cytokine-induced proliferation and act as reciprocal antagonists.
- DETERMINATION OF AN IMPROVED SIROLIMUS (Rapamycin)-BASED REGIMEN FOR INDUCTION OF ALLOGRAFT TOLERANCE IN MICE TREATED WITH …
- Structure of the human 25 kDa FK506 binding protein complexed with Rapamycin
- The effects of Rapamycin on humoral immunity in vivo. Suppression of primary responses but not of ongoing alloantibody synthesis or memory responses.
- Hypersensitivity to Rapamycin of BJAB B lymphoblastoid cells.
- … IMMUNOMODULATION LEADS TO ENHANCED ALLOGRAFT SURVIVAL IN COMBINATION WITH CYCLOSPORINE A AND Rapamycin, BUT NOT FK5061
- The effect of Rapamycin on c-jun expression in human lymphocytes
- Tritium labelling of RAD001—a new Rapamycin derivative
- Relationship between multiple biologic effects of Rapamycin and the inhibition of pp70S6 protein kinase activity. Analysis in mutant clones of a T cell lymphoma.
- In vivo inhibition of cytokine responsiveness and graft-versus-host disease mortality by Rapamycin leads to a clinical-pathological syndrome discrete from that …
- Rapamycin Prolongs Survival of Murine Recipients of Fully Allogeneic Donor Grafts When Administered during the Graft‐versus‐Host Disease Process a
- Isolation and identification of new Rapamycin dihydrodiol metabolites from dexamethasoneinduced rat liver microsomes
- Rapamycin and FK506 induce long-term potentiation by pairing stimulation via an intracellular Ca2+ signaling mechanism in rat hippocampal CA1 neurons
- … triamcinolone acetonide accumulation in mouse fibroblasts is differently modulated by the immunosuppressants cyclosporin A, FK506, Rapamycin and their analogues …
- … C/EBP homologous protein (CHOP) by amino acid deprivation requires insulin-like growth factor I, phosphatidylinositol 3-kinase, and mammalian target of Rapamycin …
- Insulin regulation of insulin-like growth factor-binding protein-1 gene expression is dependent on the mammalian target of Rapamycin, but independent of …
- Conformational changes of Rapamycin and analogs upon complexing with FKBP associated with activity: an application of second derivative CD spectroscopy
- inhibition of S6 Kinase by Rapamycin Blocks Maturation ofRana dybowskiiOocytes
- Reversible isomerization of Rapamycin demonstrated by liquid chromatography
- The human gene encoding FKBP-Rapamycin associated protein (FRAP) maps to chromosomal band 1p36. 2
- Studies towards the total synthesis of Rapamycin: Preparation of the cyclohexyl C33 C42 fragment and further coupling to afford the C22 C42 carbon unit
- The effect of anti‐IL‐4 monoclonal antibody, Rapamycin and interferon‐γ on airway hyperreactivity to acetylcholine in mice
- IL-2 induces beta2-integrin adhesion via a wortmannin/LY294002-sensitive, Rapamycin-resistant pathway. Phosphorylation of a 125-kilodalton protein correlates with …
- Biochemical and structural studies of the FK506-and Rapamycin-binding proteins (FKBPs).
- Rapamycin-sensitive phosphorylation of ribosomal protein S17 by p70 S6 kinase
- Differential inhibition of cutaneous T-cell-mediated reactions and epidermal cell proliferation by cyclosporin A, FK-506, and Rapamycin
- Cyclosporine and Rapamycin affect protein kinase C induction of the intracellular activation signal, activator of DNA replication.
- The effect of cyclosporin A, FK506, and Rapamycin on the murine chronic graft‐versus‐host response—an in vivo model of Th2‐like activity
- Efficacy of Rapamycin, RS-61443 and cyclophosphamide in the prolongation of survival of discordant pig to rabbit cardiac xenografts.
- Rapamycin graft pretreatment in small bowel and kidney transplantation in the rat.
- Left main Rapamycin-coated stent: Invasive versus noninvasive angiographic follow-up
- Investigation of Rapamycin transport and uptake across absorptive human intestinal cell monolayers
- Effects of wortmannin and Rapamycin on CSF-1-mediated responses in macrophages
- Cyclosporin A, Rapamycin and FK506 decrease prolactin release from rat pituitary cells in primary culture
- Sirolimus: mammalian target of Rapamycin inhibitor to prevent kidney rejection
- Hepatotrophic properties in dogs of human FKBP, the binding protein for FK506 and Rapamycin
- Up-regulation of cell surface sodium channels by cyclosporin A, FK506, and Rapamycin in adrenal chromaffin cells
- Synergistic effect of Rapamycin and cyclosporine in prevention of acute kidney allograft rejection in the mouse
- Isolation of a human cDNA encoding a 25 kDa FK-506 and Rapamycin binding protein
- Suppression of allograft responses by combining alloantigen-specific iv pre-sensitization with suboptimal doses of Rapamycin
- Rapamycin
- Comparison of binding characteristics of four Rapamycin metabolites to the 14 and 52 kDa immunophilins with their pharmacologic activity measured by the mixed …
- Hemolytic uremic syndrome after renal transplantation: immunosuppressive therapy with Rapamycin
- Immunosuppressants FK506 and Rapamycin have different effects on the biosynthesis of cytoplasmic actin during the early period of T cell activation
- Inducible membrane recruitment of small GTP-binding proteins by Rapamycin-based system in living cells
- Intragraft cytokine expressionf in tolerant rat renal allografts with Rapamycin and cyclosporin immunosuppression
- Evidence that Rapamycin rescue therapy delays rejection of major (MHC) plus minor (non-MHC) histoincompatible heart allografts in rats.
- Ethanol potentiates the stimulatory effects of insulin and phosphocholine on mitogenesis by a zinc-dependent and Rapamycin-sensitive mechanism in fibroblasts and …
- … CD8+ T cells tolerized in vivo: employing a model of Ld-specific TCR transgenic mice transplanted with allogenic hearts under the cover of a short-term Rapamycin …
- Insulin regulation of hepatic insulin-like growth factor-binding protein-1 (IGFBP-1) gene expression and mammalian target of Rapamycin (mTOR) signalling is impaired …
- Saccharomyces cerevisiae contains a homolog of human fkbp‐13, a membrane‐associated fk506/Rapamycin binding protein
- An unexpected inhibitory effect of Rapamycin against germination of spores of Bacillus brevis strain Nagano
- Identification of a 14 kDa FK-506/Rapamycin binding immunophilin from calf thymus
- … –electrospray mass spectrometric assay for the specific and sensitive quantification of the novel immunosuppressive macrolide 40-O-(2-hydroxyethyl) Rapamycin
- Rapamycin inhibits activation of ryanodine receptors from skeletal muscle by the fatty acyl CoA–acyl CoA binding protein complex
- Exclusion of the 13-kDa Rapamycin binding protein gene (FKBP2) as a candidate gene for multiple endocrine neoplasia type 1
- Towards the synthesis of the C37-C42 fragment of Rapamycin: intramolecular reactions of allyl silanes with oxonium ions generated from α-alkoxy sulfones.
- Quantitative and temporal analysis of the cellular interaction of FK-506 and Rapamycin in T-lymphocytes.
- … ARE NOT REQUIRED FOR INDUCTION OF ALLOGRAFT TOLERANCE IN MICE TREATED WITH ANTILYMPHOCYTE SERUM, Rapamycin, AND DONOR BONE …
- A comparison of the effects of Rapamycin and cyclosporine on kidney and heart morphology in a rabbit heterotopic heart transplant model
- Murine TRAIL (TNF-related apoptosis inducing ligand) expression induced by T cell activation is blocked by Rapamycin, cyclosporin A, and inhibitors of …
- Cyclosporine, FK-506, Rapamycin, and other immunomodulators
- Rapamycin INDUCES TGF-β PRODUCTION IN LYMPOCYTES
- Marked prolongation of rat skin xenografts induced by intrathymic injection of xenogeneic splenocytes and a short course of Rapamycin in antilymphocyte serum …
- inhibition of cellular transfer of experimental autoimmune uveoretinitis by Rapamycin
- Rapamycin: a future in cancer treatment?
- Reduction of Sephadex-induced lung inflammation and bronchial hyperreactivity by Rapamycin.
- K+ currents responsible for repolarization in mouse ventricle and their modulation by FK-506 and Rapamycin
- 14-3-3τ associates with a translational control factor FKBP12-Rapamycin-associated protein in T-cells after stimulation by pervanadate
- IL-2-dependent induction of G1 cyclins in primary T cells is not blocked by Rapamycin or cyclosporin A
- Evidence that FK506 and Rapamycin block T cell activation at different sites relative to early reversible phosphorylation involving the protein phosphatases PP1 and …
- Partial characterization of a 52 kDa CsA/FK506/Rapamycin binding protein
- Rapamycin: Therapeutic range investigations
- Brief treatment with Rapamycin in vivo increases responsiveness to alloantigens measured by the mixed lymphocyte response
- Anti-CD2 monoclonal antibodies synergize with FK506 but not with cyclosporine or Rapamycin to induce tolerance.
- Up-regulation of insulin-like growth factor binding protein-5 is independent of muscle cell differentiation, sensitive to Rapamycin, but insensitive to wortmannin and …
- The effect of cyclosporine, Rapamycin and FK 506 the survival following allogeneic bone marrow transplantation
- Treatment of normal skeletal muscle with FK506 or Rapamycin results in halothane-induced muscle contracture
- EFFECT OF IN VIVO Rapamycin TREATMENT ON DE NOVO T-CELL DEVELOPMENT IN RELATION TO INDUCTION OF AUTOIMMUNE-LIKE …
- Swinging the vote for Rapamycin
- Activation of 70‐kDa S6 kinase, induced by the cytokines interleukin‐3 and erythropoietin and inhibited by Rapamycin, is not an absolute requirement for cell …
- Rapamycin increases transforming growth factor-β mRNA expression in immortalized rat proximal renal tubular cells
- Divergent effects of Rapamycin on mouse and rat cells following mitogenic stimulation
- Differential effects of the immunosuppressive macrolides FK-506 and Rapamycin on activation-induced T-cell apoptosis
- Induction of tolerance to skin allografts by intrathymic injection of donor splenocytes. Effect of donor-recipient strain combination and supplemental Rapamycin.
- Isolation and identification of a C39 demethylated metabolite of Rapamycin from pig liver microsomes and evaluation of its immunosuppressive activity
- … from pig liver microsomes, identification by electrospray tandem mass spectrometry and in vitro immunosuppressive activity of a Rapamycin tris‐epoxide metabolite
- Ionization of the c7 methoxy group in Rapamycin by 5 M lithium perchlorate-diethyl ether
- Induction of CD5 on B and T cells is suppressed by cyclosporin A, FK-520 and Rapamycin
- Mammalian target of Rapamycin: Immunosuppressive drugs offer new insights into cell growth regulation
- Rapamycin-induced apoptosis is p53-independent in human prostate carcinoma PC-3 cells
- Probing T-cell signal transduction pathways with the immunosuppressive drugs, FK-506 and Rapamycin
- Stereoselective construction of the C 21–C 42 fragment of Rapamycin
- Rapamycin FOR REFRACTORY RENAL ALLOGRAFT REJECTION.
- C‐14 labelling of NVP RAD001—a new Rapamycin derivative
- The immunosuppressive macrolides FK-506 and Rapamycin
- Inhibitors of mammalian target of Rapamycin
- inhibition of the Mr 70,000 S6 kinase pathway by Rapamycin results in chromosome malsegregation in yeast and mammalian cells
- Possible involvement of Rapamycin-sensitive pathway in Bcl-2 expression in human neuroblastoma SH-SY5Y cells
- Ionizing radiation enhances double-strand-break repair in Rapamycin-treated ataxia telangiectasia lymphoblasts
- Effect of Rapamycin on prolactin-stimulated S6 kinase activity and milk product formation in mouse mammary explants
- Differential effect of Rapamycin and cyclosporin A in proliferation in a murine T cell line expressing either intermediate or high affinity receptor for IL-2
- A short-term combination therapy with cyclosporine and Rapamycin or leflunomide induces long-term heart allograft survival in a strongly immunogenic strain …
- FK-506 and Rapamycin but not cyclosporin inhibit aldosterone-stimulated sodium transport in A6 cells
- FK506 and Rapamycin: Differential sensitivity of human, baboon, cynomolgus monkey, dog and pig lymphocytes
- Late adjunctive therapy with single doses of Rapamycin in skin-allografted mice treated with antilymphocyte serum and donor bone marrow cells
- Rapamycin inhibits substance P-induced protein synthesis and phosphorylation of PHAS-I (4E-BP1) and p70 S6 kinase (p70 (S6K)) in human astrocytoma cells
- … peptide corresponding to residues 65–79 of an HLA class II sequence: functional similarities but mechanistic differences with the immunosuppressive drug Rapamycin
- Synthesis and bioactivity of photolabile sirolimus (Rapamycin) analogs
- Rapamycin for GVHD prophylaxis-potential for severe myelotoxicity
- Provocative effects of the immunosuppressants Rapamycin, tacrolimus, and dexamethasone on Pneumocystis carinii pneumonitis in contrast to the anti-Pneumocystis …
- Comparative effects of FK-506, Rapamycin and cyclosporin A, on the in vitro differentiation of dorsal root ganglia explants and septal cholinergic neurons
- Anti‐CD28 antibody‐and IL‐4‐induced human T cell proliferation is sensitive to Rapamycin
- Rapamycin inhibits aldolase A expression during human lymphocyte activation
- The effects of FK 506, cyclosporine, and Rapamycin on liver growth in vitro and in vivo
- Analogous conformations of both binding and effector regions in cyclosporin A, FK506 and Rapamycin
- X-ray Crystal Structure of 28-O-MethylRapamycin complexed with FKBP12: Is the Cyclohexyl Moiety Part of the Effector Domain of Rapamycin?
- Rapamycin, cyclosporine, and perioperative donor-specific transfusions induce prolongation of cardiac allograft survival in the rat.
- Structure-activity relationships involving modifications to the macrolides FK-506 and Rapamycin
- Comparative study of CSA and FK506 versus newer immunosuppressive drugs MMF and Rapamycin on coronary endothelial function in vitro
- PHAS-I phosphorylation in response to foetal bovine serum (FBS) is regulated by an ERK1/ERK2-independent and Rapamycin-sensitive pathway in 3T3-L1 …
- Structural analysis of Rapamycin and related compounds using [M + Li]+ ions generated by liquid secondary ion mass spectrometry
- The gene structure and promoter analysis of mouse lymphocyte signal transduction molecule α4 that is related to the yeast TAP42 involved in a Rapamycin-sensitive …
- The transcriptional profile of Saccharomyces cerevisiae exposed to Rapamycin mimics the profile induced by amino acid starvation
- … with chiral homoallylic ethers: An application to the asymmetric synthesis od (11R, 14S)-anti-and (31R, 34S)-syn-segements of immunosuppressant Rapamycin
- SAFETY AND PHARMACOKINETIC PROFILE OF ASCENDING SINGLE DOSES OF ORAL LIQUID SIROLIMUS (Rapamycin) IN PEDIATRIC PATIENTS WITH STABLE …
- … suppression of T cell responses to minor histocompatibility antigens by chloroquine in combination with tacrolimus and a Rapamycin derivative, SDZ-RAD
- … factor β1 inhibits interleukin‐1‐induced but enhances ionomycin‐induced interferon‐γ production in at cell lymphoma: Comparison with the effects of Rapamycin
- Long-term viability of articular cartilage after microsurgical whole-joint transplantation and immunosuppression with Rapamycin, mycophenolate mofetil, and tacrolimus
- Effect of cyclosporin A, Rapamycin, and FK-506 on corneal epithelial cells and lymphocyte proliferation
- Comparative in vitro studies on the immunosuppressive activities of mycophenolic acid, bredinin, FK 506, cyclosporine, and Rapamycin
- Responsiveness of preactivated B cells to IL-2 and IL-6. Effect of cyclosporine and Rapamycin.
- Differential effects of cyclosporin-A and Rapamycin on in vivo thymocyte maturation
- Immunopharmacology of Rapamycin (A review)
- Synergism between corticosteroids and Rapamycin for the treatment of intraocular inflammation
- Rapamycin induces binding activity to the terminal oligopyrimidine tract of ribosomal protein mRNA in rats
- Intrasplenic liver parenchymal cells in conjunction with low-dose Rapamycin and cyclosporine induce a unique and specific prolongation of rat cardiac and small bowel …
- Target of Rapamycin (TOR) signaling coordinates tRNA and 5S rRNA gene transcription with growth rate in yeast
- HPLC Analysis of Rapamycin
- TGF-beta Provides the Rationale for the Synergistic Immunpsuppression with Rapamycin (RAPA), Cyclosporine (CsA) and Tacrolimus (TAC)
- Pharmacokinetic and pharmacodynamic correlations of cyclosporine (CsA) and Rapamycin (RAPA) in 120 patients treated for at least 2 years at a single center.
- Effects of mycophenolic acid, Rapamycin, and carvedilol on the PDGF-induced fibronectin secretion by rat vascular smooth muscle cells: Implication of MAP kinase
- The Effect of Immunosuppressive Agents (FK‐506, Rapamycin) on Renal P450 Systems in Rat Models
- A comparison of in vivo responses to cyclosporine, FK506, and Rapamycin following allogeneic immune challenge
- Rapamycin inhibits the in vitro release of soluble CD23 by SAC/IL-2/IL-4-activated human peripheral blood B lymphocytes
- Comparison of FK‐506, Rapamycin, Ascomycin, and Cyclosporine in Mouse Models of Host‐versus‐Graft Disease and Heterotopic Heart Transplantation
- Generation and evaluation of putative neuroregenerative drugs: Part 2: Screening virtual libraries of novel polyketides which possess the binding domain of Rapamycin
- Steroids, Rapamycin, and breast cancer cells.
- ADDITION OF Rapamycin TO CYCLOSPORINE-PREDNISONE BASED IMMUNOSUPPRESSION REDUCES THE CLINICAL RISK OF PRETRANSPLANT ANTI …
- Rapamycin treatment depresses
- Osmotic pump delivery of Rapamycin
- An open-label multi-center clinical study of the efficacy and safety of Rapamycin in combination with CsA and steroid to prevent the acute rejection of kidney …
- inhibition of anti-CD3 antibody-induced mouse T cell activation by pentoxifylline in combination with Rapamycin or A77 1726 (leflunomide)
- Prevention of cardiac allograft rejection by FK506 and Rapamycin: assessment by histology and nuclear magnetic resonance
- Induction of IL-5 expression by IL-2 is resistant to the immunosuppressive agents cyclosporin A and Rapamycin.
- Rapamycin inhibits the in vitro release of soluble interleukin-2 receptor by activated peripheral blood mononuclear cells (PBMC) independently of the mode of …
- Rapamycin (Sirolimus) reduces luminal narrowing after balloon angioplasty in porcine coronary arteries
- The Rapamycin sensitivity of human T-cell leukaemia virus type I-induced T-cell proliferation is mediated independently of the polypyrimidine motifs in the 5′ long …
- Signaling Pathways for Translation: Stress, Calcium, and Rapamycin
- Rapamycin and reduced dose cyclosporin produce effective immunosuppression for de novo renal transplant recipients
- Differentiation by Rapamycin
- Generation and evaluation of putative neuroregenerative drugs: Part 1: virtual point mutations to the polyketide Rapamycin
- Triglyceride (TG) elevations in renal transplant recipients treated with sirolimus (Rapamycin, RAPA) added to a cyclosporine (CsA)/prednisone (pred) regimen
- Rapamycin: a new immunosuppressive agent capable of inhibiting chronic rejection?
- Effects of Rapamycin and FK 506 on Rat Sertoli Cells In Vitro
- The Immunosuppressant Rapamycin Induces Inactivation
- Effect of immunosuppressants FK506 and Rapamycin on the function of progesterone receptor: protein” p59-HBI”, intersection between immunology and endocrinology …
- Effects of Rapamycin on the proliferation and the prodution of IL-2, IFN-γ, TNF-α of spleniclymphocytes in mice [J]
- Rapamycin-inducible Secretion of a Therapeutic Protein in the Eye After Transduction With Viral Vectors
- High performance liquid chromatographic isolation and spectroscopic characterization of metabolites from the bile of rats receiving Rapamycin (sirolimus) …
- In vitro IgE production by interleukin 4-stimulated human peripheral blood mononuclear cells is suppressed by Rapamycin
- Conformational sensitivity analysis of FKBP–FK506/Rapamycin complexes
- Rapamycin (sirolimus, RapamuneTM): A novel immunosuppressive agent
- Cytokine expression in a stringent, single-dose Rapamycin, renal allograft model
- Induction of Rapamycin sensitivity by the Gli oncogene.
- Conversion from cyclosporine to Rapamycin in renal transplant recipients-Report of an initial experience.
- IL-2 DEPENDENT Rapamycin RESISTENT SIGNALS ARE REQUIRED FOR TOLERANCE INDUCTION AND T CELL APOPTOSIS
- Supercritical fluid chromatography for therapeutic drug monitoring of immunosuppressants: selectivity for cyclosporine A, FK 506 (tacrolimus), and Rapamycin
- Total syntheses of Rapamycin and 32-(S)-dihydroRapamycin.
- Rapamycin does not improve renal function or reduce profibrotic gene expression in chronic allograft nephropathy
- THE Rapamycin ANALOGUE SDZ RAD INHIBITS LPS AND ANTI-CD3mAb INDUCED IL-10 SYNTHESIS IN VITRO AND IN HUMAN RENAL ALLOGRAFT …
- Studies directed towards the synthesis of Rapamycin
- Choosing rational combinations of therapeutic agents: Contrasting effects of costimulation blockade plus Rapamycin or cyclosporin on intragraft expression of …
- Effects of FK506 and Rapamycin on formation of the neural tube in chick embryos
- Increased LFA-1-mediated homotypic cell adhesion is associated with the G1 growth arrest induced by Rapamycin in a T cell lymphoma
- The biosynthesis of Rapamycin
- Studies towards the total synthesis of Rapamycin
- FOUR-YEAR CONTROL OF A CLINICAL Rapamycin ASSAY
- Control of translation by a novel, Rapamycin-sensitive signaling pathway.
- The total synthesis of (-)-Rapamycin
- Total synthesis of Rapamycin.
- Rapamycin inhibits HMGB1 expression and releases in RAW264. 7 cells induced by lipopolysaccharides in vitro
- Effects of Rapamycin and insulin on the cell cycle and apoptosis of hybridoma cell cultures
- Rapamycin inhibits proliferating cell nuclear antigen expression and arrests keratinocytes in the G 1 phase of the cell cycle in vitro.
- The Immunophilin Ligand Rapamycin: A Probe for the Analysis of the Relationship of Apoptosis to the Cell Cycle
- Comparison between effects of mycophenolate mofetil and Rapamycin on proliferation and apoptosis of cyst-lining epithelial cells of ADPKD patients
- Synthetic methods directed towards the synthesis of Rapamycin.
- … ALLOGRAFT NEPHROPATHY: A PROSPECTIVE RANDOMISED TRIAL OF CYCLOSPORIN REDUCTION WITH OR WITHOUT Rapamycin.: Abstract# 432 Poster …
- Methionine Interference in Rapamycin
- Evaluation of the Influence of FK 506, Rapamycin, and Cyclosporine on Processing and Presentation of Particulate Antigen by Macrophages: Assessment of a …
- Sirolimus (Rapamycin) monotherapy prevents graft vascular disease in non-human primates
- Use of anti-CD25 monoclonal antibody in combination with Rapamycin to reduce or eliminate cyclosporine treatment during the induction phase of …
- Efficacy of 40-O-(2-hydroxyethyl)-Rapamycin in preventing chronic renal allograft rejection in rats
- Effect of cyclosporin A, FK506 and Rapamycin on proliferation and soluble IL-2 receptor release from mitogenically stimulated rat spleen cells
- Coadministered neoral and the new Rapamycin derivative, SDZ RAD, for nonhuman primate lung transplantation: systematic pharmcokinetic-based trials to maximize …
- Effects of Rapamycin on number and activity of endothelial progenitor cells
- Total Synthesis of Rapamycin
- Rapamycin has no effect on established allograft vasculopathy
- Total Synthesis of Rapamycin
- Therapeutic monitoring of cyclosporine, FK-506, and Rapamycin
- Insensitivity towards inhibition by cyclosporin A, Rapamycin and tacrolimus in human intestinal lamina propria T lymphocytes
- Cyclosporine but not Rapamycin stimulates endothelin-1 secretion by endothelial cells: Potential significance in transplant vasculopathy
- Rapamycin RESCUE IN PEDIATRIC LIVER RECIPIENTS WITH TACROLIMUS TOXICITY. A PRELIMINARY EFFECT: CONCENTRATION ANALYSIS.: Abstract# 210 …
- Studies towards the total synthesis of Rapamycin
- Inhibitory Effects of Rapamycin on the Experimental Allograft Rejection
- Innovative technique for immunosuppresion involving administration of Rapamycin loaded formed blood elements
- Regulation and identification of Rapamycin sensitive phosphorylation sites of p70s6k
- Studies directed toward the synthesis of the southern fragment of Rapamycin
- Inhibitors of Mammalian Target of Rapamycin
- Effect of Rapamycin on allograft rejection and immune response in mice
- In vitro and in vivo assessment of Rapamycin as an immunosuppressive agent in the rabbit
- Synthetic studies on the C10-C17 fragment of Rapamycin
- Effects of Rapamycin on the proliferation and the prodution of IL-2, IFN-?, TNF-? of spleniclymphocytes in mice
- Synergism between corticosteroids and Rapamycin for the treatment of intraocular inflammation
- Rapamycin and C (27)-demethoxyRapamycin: An efficient stereocontrolled synthesis of the C (1)-C (20) and C (22)-C (26) fragments.
- The effect of Rapamycin in prologation of adrenal allograft survival in the rat
- inhibition of cellular transfer of experimental autoimmune uveoretinitis by Rapamycin
- Rapamycin and other natural products affect regulation of the growth and differentiation of Saccharomyces cerevisiae.
- Biosynthesis of Rapamycin by streptomyces hygroscopicus
- Rapamycin, FRAP and the Control of 5’TOP mRNA Translation
- Synergistic effects of mycophenolate mofetil (MMF) and sirolimus (Rapamycin, RAPA) in prevention of acute heart, pancreas and kidney allograft rejection and in …
- Therapeutic window of whole blood Rapamycin concentration in recipients of renal transplantation
- Syntheses and biological activities of natural products: Rapamycin, balanol and the maduropeptin chromophore.
- The immunosuppressive effect of Rapamycin on lymphocytic proliferation and DTH, GVHR
- Risk factors for Rapamycin-induced thrombocytopenia and leukopenia in renal transplant recipients
- Immunosuppressive effect of Rapamycin on heart allotransplantation in the rat [J]
- The effect of soy protein on serum lipids in kidney transplant patients receiving Rapamycin.
- Aberrant expression of mammalian target of Rapamycin in stage ⅢB colon cancer and its significance
- Rapamycin Inhibits 3T3-L1 Adipocyte Differentiation Independent of Clonal Expansion
- Effect of Rapamycin on the cyclosporin A-resistant CD28-mediated
- Synthetic approaches to the tricarbonyl subunit of Rapamycin
- Molecular mechanisms of action of the immunosuppressive drugs cyclosporin A, FK506 and Rapamycin.
- Effects of Rapamycin on chronic nephrotoxicity induced by cyclosporine A in rats
- Rapamycin antagonizes interleukin-6 mediated growth arrest and differentiation of myeloblastic M1 cells
- Cyclin D3, a key cyclin in human lymphocyte proliferation and Rapamycin-mediated immunosuppression.
- EXTREME HYPERLIPIDEMIA RESULTING FROM Rapamycin-DERIVED DRUG ADMINISTRATION.: Abstract# 827 Poster Board#-Session: P84-III
- Siloxanes as templates in asymmetric synthesis: Studies directed towards the synthesis of Rapamycin.
- FK 506 versus cyclosponne a for steroid-free synergistic combination therapy with Rapamycin in a discordant large animal donor xenoislet transplant model
- Studies of the Rapamycin-sensitive signaling network using genomics, chemical genetics, and small molecule microarrays.
- Rapamycin increases the expression of genes responsible for extracellular matrix remodelling compared to neoral in rat allografts
- Inhibitory effects of Rapamycin on intimal hyperplasia after PTCA in the porcine coronary model: a 3-month follow-up
- Regulation of the cell integrity pathway by Rapamycin-sensitive TOR function in budding yeast
- Rapamycin Inhibits Estrogen-Mediated Transcription in Breast Cancer Cell Lines
- Tissue Distribution of Rapamycin and Cyclosporine in the Rat: Comparison of Single vs. Dual Drug Therapy
- inhibition by Rapamycin of PDGF-and bFGF-induced human tenon fibroblast proliferation in vitro
- Effects of Rapamycin and wortmannin on the insulin stimulation of protein synthesis in rat skeletal muscle and L6 myoblasts
- The expression of mammalian target of Rapamycin in autogenous vein graft in rats
- The Effects of Immunosuppressants Rapamycin and Cyclosporin A on the Proliferation, Cell Cycle, and Cyclin Expression of Cultured Human Keratinocyte Cell Line …
- The effects of Rapamycin and cyclosporin a on tolerance induction through bone marrow transplantation with costimulation blockade
- Cyclosporin and FK506, but not Rapamycin, increase DNFB induced TNF-alpha expression in human epidermal sheets.
- Mass spectrometric analysis of the Rapamycin-dependent phosphorylation sites of the yeast protein kinase NPR1
- Effects of stent-based delivery of Rapamycin and methotrexate on neointimal formation in a porcine coronary model
- Effects of cyclosporin and Rapamycin on the in vitro activation of human CD8+ lymphocytes in comparison with peripheral blood mononuclear cells.
- Evaluation of Rapamycin coated stents by multi row detector computed angiography: comparison to quantitative angiographic results
- Cyclosporin A and FK506, but not Rapamycin, increase DNFB induced TNF-alpha expression in human epidermal sheets.
- Using natural products to elucidate molecular events within cells: Molecular mechanisms of action of cyclosporine, FK506, and Rapamycin.
- SDZ-RAD PREVENTS CYCLOSPORINE-INDUCED inhibition OF BRAIN ENERGY METABOLISM: COMPARISON WITH Rapamycin.: Abstract# 314 Poster Board …
- Rapamycin POTENTIATES NF-κB AND AP-1 ACTIVATION IN TNF-α TREATED PRIMARY RAT HEPATOCYTES.: Abstract# 308 Poster Board#-Session: P155-I
- The Mechanism of Insulin-Induced Clonal Expansion in Adipocyte Differentiation–the Importance of PI3 Kinae-Rapamycin-Sensitive Pathway
- Inhibitory effects of Rapamycin and ascomycin on hair growth induced by cyclosporin A and FK506 in mice.
- Effects of Rapamycin-treated HSP60-pulsed dendritic cells on the progression of the atherosclerotic plaque in mice
- inhibition of S6 Kinase by Rapamycin Blocks Maturation of Rana dybowskii Oocytes
- Relationship between multiple biological effects of Rapamycin and the inhibition of pp70 S6 protein kinase activity: Analysis in mutant clones of a T cell lymphoma.
- The study of Rapamycin-eluting polymer-coated stents to prevent restenosis in the porcine coronary injury model
- Differential effects of cyclosporine and Rapamycin on costimulation blockade induced allograft tolerance: Intragraft CTL gene expression analysis
- BRIEF COMMUNICATIONS: EFFECT OF Rapamycin ON RENAL ALLOGRAFT SURVIVAL IN CANINE RECIPIENTS TREATED WITH ANTILYMPHOCYTE SERUM …
- Rapamycin RESCUE IN PEDIATRIC LIVER RECIPIENTS WITH TACROLIMUS TOXICITY.: Abstract# 211 Poster Board#-Session: P58-I
- Rapamycin (RAPA) lowers dose requirements of cyclosporin (CsA) in renal transplant patients (RTx)
- … Lewis acid-mediated Mukaiyama aldol reaction of α-alkoxythiolketene acetals with α, β-disubstituted enals: synthesis of the C26–C33 segment of Rapamycin
- Rapamycin selectively inhibits translation of mRNAs encoding elongation factor and ribosomal protein
- FK506 versus CSA for steroid-free synergistic combination therapy with Rapamycin (Rapa) in a discordant xenoislet model
- SHORT TERM ANTILYMPHOCYTE SERUM, Rapamycin AND DONOR BONE MARROW SIGNIFICANTLY SUPPRESS ANTIDONOR ANTIBODY AND PROLONG …
- … studies n bioactive natural products. Part I, An approach towards the nootrophic agent huperzine A. Part II, Synthesis of the tricarbonyl subunit of Rapamycin
- EFFECT OF TACROLIMUS (FK506) AND SIROLIMUS (Rapamycin) MONO-AND COMBINATION THERAPY IN PROLONGATION OF RENAL ALLOGRAFT …
- Coadministration of neoral and the novel Rapamycin analog, sdzrad, to. lung allograft recipients: potentiation of immunosuppressive efficacy and reduction of toxicity …
- Rapamycin (Rapa) And Cyclosporin A (Csa) Enhance Transforming Growth Factor Beta (TGF-β1) Expression in Immortalized Rat Proximal Tubules (IRPTC)† 1840
- Rapamycin (RAPA) ENHANCES TRANSFORMING GROWTH FACTOR BETA (TGF-β1) EXPRESSION IN IMMORTALIZED RAT PROXIMAL TUBULES CELLS …
- Prevention of Arterial Restenosis by Rapamycin and Mycophenolate Mofetil: A New Role for Novel Immunosuppressants in the Prevention of Post-Balloon Angioplasty …
- Rapamycin synergizes with dst plus anti-CD154 to block auto and allo-immune response and induce islet allograft engraftment in spontaneous autoimmune diabetic …
- Mating stimulate protein phosphorylation and synthesis via Rapamycin-and wortmannin-sensitive manner in male accessory glands of D. melanogaster
- Combined use of mycophenolate mofetil (MMF) and Rapamycin (RAPA) in prevention of acute heart allograft rejection and reversal of ongoing cardiac allograft …
- Chronic Rejection in Non-human Primates: Sirolimus (Rapamycin), but not Cyclosporin, Prevents Graft Vascular Disease (GVD) in Aortic Allografts after Acute …
- Provocative effects of the immunosuppressants Rapamycin, tacrolimus, and dexamethasone on Pneumocystis carinii pneumonitis in contrast to the anti-Pneumocystis …
- Synthesis of the C-21-C-42 fragment of Rapamycin and total synthesis of Rapamycin.
- PMA Induced Ser/Thr Phosphorylation of IRS-1 Mediated by Rapamycin-Sensitive Pathway
- Desensitization of Insulin Action through Ser/Thr Phosphorylation and Degradation of IRS-1 by Activation of Rapamycin-Sensitive Pathway
- 24 HPLC (ESI)-MS IDENTIFICATION OF SIROLIMUS (Rapamycin) METABOLITES GENERATED IN A RABBIT MICROSOMAL SYSTEM AND CONFIRMATION WITH …
- Interleukin-2 and Rapamycin regulation of cyclin E-Cdk2 kinase, the Cdk inhibitor, P27KIP1, and the T lymphocyte cell cycle.
- 192 SENSITIVE AND SPECIFIC QUANTIFICATION OF SIROLIMUS (Rapamycin) AND ITS METABOLITES IN BLOOD AND URINE OF KIDNEY GRAFT RECIPIENTS …
- OP-4. Studies towards the Total Synthesis of Rapamycin
- 74 DETERMINATION OF Rapamycin IN WHOLE BLOOD BY HPLC
- # 680 In vitro evaluation of Rapamycin sensitivity and synergy with cisplatin and camptothecin in medulloblastoma
- Purification and characterization of a 50 kiloDalton lymphocyte-derived binding protein for cyclosporin, FK-506 and Rapamycin.
- … from carbohydrates: Application of the (2, 3)-Wittig rearrangement of carbohydrate-derived alpha-alkoxy tertiary allylic ethers to the syntheses of Adda and Rapamycin.
- Efficacy of FK-506 and Rapamycin in Prolongation of Allograft Rat Limb Survival
- # 764 Rapamycin effects phosphorylation of p70S6 kinase and other intermediaries in medulloblastoma
- I. The formal synthesis of FK-506. II. A simple synthesis of vicinal tricarbonyls. III. Studies toward the synthesis of Rapamycin.
- Glucose-induced polypyrimidine-tract-binding protein (PTB) to the 3´-untranslated region of the insulin mRNA is inhibited by Rapamycin
- METABOLISM AND PHARMACOKINETICS OF THE NEW IMMUNOSUPPRESSANT 40-O-(2-HYDROXY)-ETHYL-Rapamycin
- 138 Rapamycin AND CYCLOSPORINE DRUG STUDIES IN THE RAT MODEL
- Rapamycin: an anti-cancer immunosuppressant?
- Determinants of Rapamycin sensitivity in breast cancer cells
- Antileukemic activity of Rapamycin in acute myeloid leukemia
- Molecular organization of target of Rapamycin complex 2
- Rapamycin-induced oligospermia
- mTOR-targeted therapy of cancer with Rapamycin derivatives
- Rapamycin pre-treatment protects against apoptosis
- Activation of Akt and eIF4E survival pathways by Rapamycin-mediated mammalian target of Rapamycin inhibition
- Signaling by target of Rapamycin proteins in cell growth control
- Differential effects of Rapamycin on mammalian target of Rapamycin signaling functions in mammalian cells
- Rapamycin alleviates toxicity of different aggregate-prone proteins
- Prolonged Rapamycin treatment inhibits mTORC2 assembly and Akt/PKB
- Rapamycin attenuates load-induced cardiac hypertrophy in mice
- Use of Rapamycin slows progression of cardiac transplantation vasculopathy
- Rapamycin markedly slows disease progression in a rat model of polycystic kidney disease
- Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells
- Rapamycin is an effective inhibitor of human renal cancer metastasis
- Maintenance immunosuppression with target-of-Rapamycin inhibitors is associated with a reduced incidence of de novo malignancies
- Rapamycin causes regression of astrocytomas in tuberous sclerosis complex
- Campath‐1H induction plus Rapamycin monotherapy for renal transplantation: results of a pilot study
- Phosphorylation of Mammalian Target of Rapamycin (mTOR) at Ser-2448 IsMediated by p70S6 Kinase
- Target of Rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression
- Pathological angiogenesis is induced by sustained Akt signaling and inhibited by Rapamycin
- Characterization of the FKBP⊙ Rapamycin⊙ FRB Ternary Complex
- inhibition of target of Rapamycin signaling by Rapamycin in the unicellular green alga Chlamydomonas reinhardtii
- Insulin/IGF and target of Rapamycin signaling: a TOR de force in growth control
- Targeting the molecular target of Rapamycin (mTOR)
- inhibition of mTOR signaling with Rapamycin regresses established cardiac hypertrophy induced by pressure overload
- The molecular target of Rapamycin (mTOR) as a therapeutic target against cancer
- Regulation of adipocyte differentiation and insulin action with Rapamycin
- Effects of Rapamycin in the Eker rat model of tuberous sclerosis complex
- Targeting the mammalian target of Rapamycin (mTOR): a new approach to treating cancer
- Target of Rapamycin-mediated amino acid signaling in mosquito anautogeny
- Multiple roles of Tap42 in mediating Rapamycin-induced transcriptional changes in yeast
- Rapamycin impairs antigen uptake of human dendritic cells1
- Rapamycin-eluting stents for the treatment of bifurcated coronary lesions: a randomized comparison of a simple versus complex strategy
- Mammalian target of Rapamycin inhibition as therapy for hematologic malignancies
- Dissociation of raptor from mTOR is a mechanism of Rapamycin‐induced inhibition of mTOR function
- GβL, a positive regulator of the Rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR
- Mammalian target of Rapamycin: a new molecular target for breast cancer
- Combination of Rapamycin and protein tyrosine kinase (PTK) inhibitors for the treatment of leukemias caused by oncogenic PTKs
- A novel hypoxia-inducible factor-independent hypoxic response regulating mammalian target of Rapamycin and its targets
- Immunosuppressants and skin cancer in transplant patients: focus on Rapamycin
- Rapamycin promotes expansion of functional CD4+ CD25+ FOXP3+ regulatory T cells of both healthy subjects and type 1 diabetic patients
- Specific binding to intracellular proteins determines arterial transport properties for Rapamycin and paclitaxel
- Rapamycin stimulates apoptosis of childhood acute lymphoblastic leukemia cells
- Targeting mammalian target of Rapamycin synergistically enhances chemotherapy-induced cytotoxicity in breast cancer cells
- Upstream of the mammalian target of Rapamycin: do all roads pass through mTOR?
- Rictor, a novel binding partner of mTOR, defines a Rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
- Phospholipase D confers Rapamycin resistance in human breast cancer cells
- Thr2446 is a novel mammalian target of Rapamycin (mTOR) phosphorylation site regulated by nutrient status
- Nephrotoxicity of Rapamycin: an emerging problem in clinical medicine
- Rapamycin analogs with differential binding specificity permit orthogonal control of protein activity
- The mammalian target of Rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity
- Rapamycin attenuates unilateral ureteral obstruction-induced renal fibrosis
- Rapamycin reduces disease activity and normalizes T cell activation–induced calcium fluxing in patients with systemic lupus erythematosus
- Rapamycin suppresses experimental aortic aneurysm growth
- Rapamycin is active against B-precursor leukemia in vitro and in vivo, an effect that is modulated by IL-7-mediated signaling
- Rapamycin has a deleterious effect on MIN-6 cells and rat and human islets
- Antiangiogenic potential of the mammalian target of Rapamycin inhibitor temsirolimus
- Mammalian TOR complex 2 controls the actin cytoskeleton and is Rapamycin insensitive
- Rapamycin protects allografts from rejection while simultaneously attacking tumors in immunosuppressed mice
- The Pim kinases control Rapamycin-resistant T cell survival and activation
- Akt activates the mammalian target of Rapamycin by regulating cellular ATP level and AMPK activity
- Mammalian target of Rapamycin, a molecular target in squamous cell carcinomas of the head and neck
- Finding new components of the target of Rapamycin (TOR) signaling network through chemical genetics and proteome chips
- Stent implantation activates RhoA in human arteries: inhibitory effect of Rapamycin
- Regulation of targets of mTOR (mammalian target of Rapamycin) signalling by intracellular amino acid availability.
- Rapamycin for treatment of chronic allograft nephropathy in renal transplant patients
- Sustained activation of the JNK cascade and Rapamycin-induced apoptosis are suppressed by p53/p21Cip1
- Combination of the mTOR inhibitor Rapamycin and CC-5013 has synergistic activity in multiple myeloma
- Rapamycin and interleukin-10 treatment induces T regulatory type 1 cells that mediate antigen-specific transplantation tolerance
- Gene expression-based chemical genomics identifies Rapamycin as a modulator of MCL1 and glucocorticoid resistance
- Rapamycin activates Tap42‐associated phosphatases by abrogating their association with Tor complex 1
- Preliminary observations regarding angiographic pattern of restenosis after Rapamycin-eluting stent implantation
- Mutasynthesis of Rapamycin analogues through the manipulation of a gene governing starter unit biosynthesis
- Curcumin inhibits the mammalian target of Rapamycin‐mediated signaling pathways in cancer cells
- Mammalian target of Rapamycin pathway blockade slows progression of diabetic kidney disease in rats
- The solution structure of the FATC domain of the protein kinase target of Rapamycin suggests a role for redox-dependent structural and cellular stability
- Mammalian target of Rapamycin regulates IRS-1 serine 307 phosphorylation
- The stress-inducted proteins RTP801 and RTP801L are negative regulators of the mammalian target of Rapamycin pathway
- Rapamycin, and not cyclosporin A, preserves the highly suppressive CD27+ subset of human CD4+CD25+ regulatory T cells
- Insights into TOR function and Rapamycin response: chemical genomic profiling by using a high-density cell array method
- Survival signaling by Notch1: mammalian target of Rapamycin (mTOR)–dependent inhibition of p53
- Antitumoral activity of Rapamycin in renal angiomyolipoma associated with tuberous sclerosis complex
- Rapamycin successfully treats post‐transplant autoimmune hepatitis
- Increased activation of the mammalian target of Rapamycin pathway in liver and skeletal muscle of obese rats: possible involvement in obesity-linked insulin resistance
- Rapamycin: signaling in vascular smooth muscle
- Therapeutic potential of target of Rapamycin inhibitors
- Synergistic augmentation of Rapamycin-induced autophagy in malignant glioma cells by phosphatidylinositol 3-kinase/protein kinase B inhibitors
- Rapamycin inhibits proliferation and differentiation of human endothelial progenitor cells in vitro
- Rheb binding to mammalian target of Rapamycin (mTOR) is regulated by amino acid sufficiency
- Rapamycin-sensitive pathway regulates mitochondrial membrane potential, autophagy, and survival in irradiated MCF-7 cells
- Inhibitory effect of Rapamycin on corneal neovascularization in vitro and in vivo
- Regulation of peroxisome proliferator–activated receptor-γ activity by mammalian target of Rapamycin and amino acids in adipogenesis
- inhibition of mTOR signaling with Rapamycin attenuates renal hypertrophy in the early diabetic mice
- Identification of S6 kinase 1 as a novel mammalian target of Rapamycin (mTOR)-phosphorylating kinase
- Rapamycin inhibits IL-4—induced dendritic cell maturation in vitro and dendritic cell mobilization and function in vivo
- Mammalian target of Rapamycin inhibition
- Phase I/II study of the mammalian target of Rapamycin inhibitor everolimus (RAD001) in patients with relapsed or refractory hematologic malignancies
- Mechanical stimuli regulate Rapamycin-sensitive signalling by a phosphoinositide 3-kinase-, protein kinase B-and growth factor-independent mechanism
- Dosing of Rapamycin is critical to achieve an optimal antiangiogenic effect against cancer
- A possible linkage between AMP‐activated protein kinase (AMPK) and mammalian target of Rapamycin (mTOR) signalling pathway
- Rapamycin induces tumor-specific thrombosis via tissue factor in the presence of VEGF
- Acute Rapamycin nephrotoxicity in native kidneys of patients with chronic glomerulopathies
- Rapamycin sensitizes multiple myeloma cells to apoptosis induced by dexamethasone
- AKT activity determines sensitivity to mammalian target of Rapamycin (mTOR) inhibitors by regulating cyclin D1 and c-myc expression
- Inhibitors of the mammalian target of Rapamycin
- Homodirectional changes in transcriptome composition and mRNA translation induced by Rapamycin and heat shock
- Rapamycin, but not FK-506, increases endothelial tissue factor expression: implications for drug-eluting stent design
- Oral Rapamycin after coronary bare-metal stent implantation to prevent restenosis: the Prospective, Randomized Oral Rapamycin in Argentina (ORAR II) Study
- Rapamycin-mediated inhibition of mammalian target of Rapamycin in skeletal muscle cells reduces glucose utilization and increases fatty acid oxidation
- Rapamycin inhibits ezrin-mediated metastatic behavior in a murine model of osteosarcoma
- Rapamycin inhibits the growth and metastatic progression of non-small cell lung cancer
- Effect of Rapamycin alone and in combination with antiangiogenesis therapy in an orthotopic model of human pancreatic cancer
- Efficacy of a Rapamycin analog (CCI‐779) and IFN‐γ in tuberous sclerosis mouse models
- Rapamycin confers preconditioning-like protection against ischemia–reperfusion injury in isolated mouse heart and cardiomyocytes
- Drosophila target of Rapamycin kinase functions as a multimer
- Targeting the Akt/mammalian target of Rapamycin pathway for radiosensitization of breast cancer
- A selective small molecule c-MET Inhibitor, PHA665752, cooperates with Rapamycin
- Arabidopsis TARGET OF Rapamycin interacts with RAPTOR, which regulates the activity of S6 kinase in response to osmotic stress signals
- Rapamycin in cardiovascular medicine
- Mechanical stimuli and nutrients regulate Rapamycin‐sensitive signaling through distinct mechanisms in skeletal muscle
- FKBP12-Rapamycin-associated protein or mammalian target of Rapamycin (FRAP/mTOR) localization in the endoplasmic reticulum and the Golgi apparatus
- S6K1−/−/S6K2−/− mice exhibit perinatal lethality and Rapamycin-sensitive 5′-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein …
- Determinants of sensitivity and resistance to Rapamycin-chemotherapy drug combinations in vivo
- Brain-derived neurotrophic factor induces mammalian target of Rapamycin-dependent local activation of translation machinery and protein synthesis in neuronal …
- In vitro study of release mechanisms of paclitaxel and Rapamycin from drug-incorporated biodegradable stent matrices
- The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of Rapamycin by amino acids and certain cellular stresses
- Rapamycin inhibits cell motility by suppression of mTOR-mediated S6K1 and 4E-BP1 pathways
- Rapamycin‐sensitive signalling in long‐term consolidation of auditory cortex‐dependent memory
- Systemic Rapamycin inhibits retinal and choroidal neovascularization in mice
- inhibition of the mammalian target of Rapamycin (mTOR) by Rapamycin increases chemosensitivity of CaSki cells to paclitaxel
- Target of Rapamycin inhibitors (sirolimus and everolimus) for primary immunosuppression of kidney transplant recipients: a systematic review and meta-analysis of …
- Rapamycin‐treated, alloantigen‐pulsed host dendritic cells induce ag‐specific T cell regulation and prolong graft survival
- Activation of mammalian target of Rapamycin in cytomegalic neurons of human cortical dysplasia
- Mutation in TSC2 and activation of mammalian target of Rapamycin signalling pathway in renal angiomyolipoma
- inhibition of mammalian target of Rapamycin or apoptotic pathway induces autophagy and radiosensitizes PTEN null prostate cancer cells
- Role of mammalian target of Rapamycin signaling in compensatory renal hypertrophy
- Rapamycin synergizes with the epidermal growth factor receptor inhibitor erlotinib in non–small-cell lung, pancreatic, colon, and breast tumors
- Rapamycin ameliorates proteinuria-associated tubulointerstitial inflammation and fibrosis in experimental membranous nephropathy
- Activation of the Akt/mammalian target of Rapamycin/4E-BP1 pathway by ErbB2 overexpression predicts tumor progression in breast cancers
- Autophagy for cancer therapy through inhibition of pro-apoptotic proteins and mammalian target of Rapamycin signaling
- BDNF regulates the translation of a select group of mRNAs by a mammalian target of Rapamycin-phosphatidylinositol 3-kinase-dependent pathway during neuronal …
- Antitumor efficacy of intermittent treatment schedules with the Rapamycin derivative RAD001 correlates with prolonged inactivation of ribosomal protein S6 kinase 1 in …
- The mammalian target of Rapamycin signaling network and gene regulation
- Combination mammalian target of Rapamycin inhibitor Rapamycin and HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin has synergistic activity in multiple …
- Role of glycogen synthase kinase 3β in Rapamycin-mediated cell cycle regulation and chemosensitivity
- Immediate response of mammalian target of Rapamycin (mTOR)‐mediated signalling following acute resistance exercise in rat skeletal muscle
- Proteomic analysis reveals hyperactivation of the mammalian target of Rapamycin pathway in neurofibromatosis 1–associated human and mouse brain tumors
- Rapamycin (sirolimus) for treatment of chronic graft-versus-host disease
- Mutual antagonism of target of Rapamycin and calcineurin signaling
- Rapamycin inhibits the interleukin 10 signal transduction pathway and the growth of Epstein Barr virus B-cell lymphomas
- inhibition of corneal neovascularization by Rapamycin
- Calcineurin inhibitors, but not Rapamycin, reduce percentages of CD4+ CD25+ FOXP3+ regulatory T cells in renal transplant recipients
- Androgens induce prostate cancer cell proliferation through mammalian target of Rapamycin activation and post-transcriptional increases in cyclin D proteins
- Dexamethasone represses signaling through the mammalian target of Rapamycin in muscle cells by enhancing expression of REDD1
- In vitro release of the mTOR inhibitor Rapamycin from poly (ethylene glycol)-b-poly (ε-caprolactone) micelles
- Low-dose oral Rapamycin treatment reduces fibrogenesis, improves liver function, and prolongs survival in rats with established liver cirrhosis
- Antitumor activity of Rapamycin in a transgenic mouse model of ErbB2-dependent human breast cancer
- Translational control via the mammalian target of Rapamycin pathway is critical for the formation and stability of long-term fear memory in amygdala neurons
- Rapamycin induces Smad activity in prostate cancer cell lines
- Resistance exercise increases muscle protein synthesis and translation of eukaryotic initiation factor 2Bϵ mRNA in a mammalian target of Rapamycin …
- Differential effect of calcineurin inhibitors, anti-CD25 antibodies and Rapamycin on the induction of FOXP3 in human T cells
- The mammalian target of Rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif
- Effects of the mammalian target of Rapamycin inhibitor CCI-779 used alone or with chemotherapy on human prostate cancer cells and xenografts
- Rapamycin inhibits doxorubicin-induced NF-κB/Rel nuclear activity and enhances the apoptosis of melanoma cells
- Spatial memory formation and memory-enhancing effect of glucose involves activation of the tuberous sclerosis complex–mammalian target of Rapamycin pathway
- Rapamycin induces heme oxygenase-1 in human pulmonary vascular cells: implications in the antiproliferative response to Rapamycin
- New targets for therapy in breast cancer: mammalian target of Rapamycin (mTOR) antagonists
- Modulation of the mammalian target of Rapamycin pathway by diacylglycerol kinase-produced phosphatidic acid
- Human cytomegalovirus infection induces Rapamycin-insensitive phosphorylation of downstream effectors of mTOR kinase
- Mammalian target of Rapamycin inhibitors activate the AKT kinase in multiple myeloma cells by up-regulating the insulin-like growth factor receptor/insulin receptor …
- … predictors of angiographic restenosis after sirolimus-eluting stent implantation in complex patients: an evaluation from the Rapamycin-Eluting Stent Evaluated At …
- Loss of Tsc1 or Tsc2 induces vascular endothelial growth factor production through mammalian target of Rapamycin
- Ischemia-reperfusion induces glomerular and tubular activation of proinflammatory and antiapoptotic pathways: differential modulation by Rapamycin
- Rpd3p relocation mediates a transcriptional response to Rapamycin in yeast
- Plumbagin induces G2-M arrest and autophagy by inhibiting the AKT/mammalian target of Rapamycin pathway in breast cancer cells
- Randomized phase II study of multiple dose levels of CCI-779, a novel mammalian target of Rapamycin kinase inhibitor, in patients with advanced refractory renal cell …
- Rapamycin-associated post-transplantation glomerulonephritis and its remission after reintroduction of calcineurin-inhibitor therapy
- Activation of the mammalian target of Rapamycin pathway acutely inhibits insulin signaling to Akt and glucose transport in 3T3-L1 and human adipocytes
- Akt1 Activation Can Augment Hypoxia-Inducible Factor-1α Expression by Increasing Protein Translation through a Mammalian Target of Rapamycin–Independent …
- Rapamycin inhibits GM-CSF-induced neutrophil migration
- The mammalian target of the Rapamycin (mTOR) kinase pathway: its role in tumourigenesis and targeted antitumour therapy
- Delayed graft function and cast nephropathy associated with tacrolimus plus Rapamycin use
- Biosynthesis of pipecolic acid by RapL, a lysine cyclodeaminase encoded in the Rapamycin gene cluster
- Recent developments in targeting the mammalian target of Rapamycin (mTOR) kinase pathway
- Domains of Gln3p interacting with karyopherins, Ure2p, and the target of Rapamycin protein
- Rapamycin-eluting stents for the treatment of unprotected left main coronary disease
- Rapamycin induces regression of endometriotic lesions by inhibiting neovascularization and cell proliferation
- Activation of mammalian target of Rapamycin signaling pathway contributes to tumor cell survival in anaplastic lymphoma kinase–positive anaplastic large cell …
- Rapamycin-induced endothelial cell death and tumor vessel thrombosis potentiate cytotoxic therapy against pancreatic cancer
- Activation of mammalian target of Rapamycin (mTOR) by insulin is associated with stimulation of 4EBP1 binding to dimeric mTOR complex 1
- Mammalian target of Rapamycin inhibition promotes response to epidermal growth factor receptor kinase inhibitors in PTEN-deficient and PTEN-intact glioblastoma …
- inhibition of mammalian target of Rapamycin reverses alveolar epithelial neoplasia induced by oncogenic K-ras
- Raptor, a binding partner of target of Rapamycin
- Rapamycin-mediated enrichment of T cells with regulatory activity in stimulated CD4+ T cell cultures is not due to the selective expansion of naturally occurring …
- Rapamycin improves lymphoproliferative disease in murine autoimmune lymphoproliferative syndrome (ALPS)
- Molecular mechanisms through which amino acids mediate signaling through the mammalian target of Rapamycin
- … outcome after drug-eluting stent implantation for the percutaneous treatment of left main coronary artery disease: insights from the Rapamycin-Eluting and Taxus Stent …
- Rapamycin biosynthesis: elucidation of gene product function
- Effect of Rapamycin on mouse chronic lymphocytic leukemia and the development of nonhematopoietic malignancies in Eμ-TCL1 transgenic mice
- Roles of glutamate receptors and the mammalian target of Rapamycin (mTOR) signaling pathway in activity-dependent dendritic protein synthesis in …
- New Rapamycin derivatives by precursor‐directed biosynthesis
- Thyroid Hormone Induces Rapid Activation of Akt/Protein Kinase B-Mammalian Target of Rapamycin-p70S6K Cascade through Phosphatidylinositol 3-Kinase in …
- Target of Rapamycin-dependent activation of S6 kinase is a central step in the transduction of nutritional signals during egg development in a mosquito
- inhibition of mammalian target of Rapamycin activates apoptosis signal-regulating kinase 1 signaling by suppressing protein phosphatase 5 activity
- … growth factor-1 (IGF-1) inversely regulates atrophy-induced genes via the phosphatidylinositol 3-kinase/Akt/mammalian target of Rapamycin (PI3K/Akt/mTOR) …
- Novel role of the small GTPase Rheb: its implication in endocytic pathway independent of the activation of mammalian target of Rapamycin
- Chronic inhibition of mammalian target of Rapamycin signaling downregulates insulin receptor substrates 1 and 2 and AKT activation: a crossroad between cancer and …
- Rapamycin-induced translational derepression of GCN4 mRNA involves a novel mechanism for activation of the eIF2α kinase GCN2
- Control of dendritic arborization by the phosphoinositide-3′-kinase–Akt–mammalian target of Rapamycin pathway
- Rapamycin induces the fusion-type independent downregulation of the EWS/FLI-1 proteins and inhibits Ewing’s sarcoma cell proliferation
- Rapamycin-induced G1 arrest in cycling B-CLL cells is associated with reduced expression of cyclin D3, cyclin E, cyclin A, and survivin
- Mammalian target of Rapamycin as a therapeutic target in leukemia
- Activation of mammalian target of Rapamycin signaling promotes cell cycle progression and protects cells from apoptosis in mantle cell lymphoma
- Nutrient-dependent multimerization of the mammalian target of Rapamycin through the N-terminal HEAT repeat region
- Akt up-regulation increases resistance to microtubule-directed chemotherapeutic agents through mammalian target of Rapamycin
- Mammalian target of Rapamycin (mTOR) inhibitors as anti-cancer agents
- Long-term treatment of bile duct-ligated rats with Rapamycin (sirolimus) significantly attenuates liver fibrosis: analysis of the underlying mechanisms
- Mechanism by which mammalian target of Rapamycin inhibitors sensitize multiple myeloma cells to dexamethasone-induced apoptosis
- Bcr-Abl kinase modulates the translation regulators ribosomal protein S6 and 4E-BP1 in chronic myelogenous leukemia cells via the mammalian target of Rapamycin
- Mammalian target of Rapamycin inhibition induces cell cycle arrest in diffuse large B cell lymphoma (DLBCL) cells and sensitises DLBCL cells to rituximab
- Tristetraprolin regulates Cyclin D1 and c-Myc mRNA stability in response to Rapamycin in an Akt-dependent manner via p38 MAPK signaling
- The Rapamycin analog CCI-779 is a potent inhibitor of pancreatic cancer cell proliferation
- Pilot trial of oral Rapamycin for recalcitrant restenosis
- Effect of Rapamycin on renal ischemia‐reperfusion injury in mice
- Rapamycin delays but does not prevent recovery from acute renal failure: role of acquired tubular resistance
- ErbB2 increases vascular endothelial growth factor protein synthesis via activation of mammalian target of Rapamycin/p70S6K leading to increased angiogenesis and …
- Rapamycin specifically interferes with GM-CSF signaling in human dendritic cells, leading to apoptosis via increased p27KIP1 expression
- Successful conversion to Rapamycin for calcineurin inhibitor-related neurotoxicity following liver transplantation
- Synergistic effect of targeting mTOR by Rapamycin and depleting ATP by inhibition of glycolysis in lymphoma and leukemia cells
- Cyclosporin A and tacrolimus, but not Rapamycin, inhibit MHC-restricted antigen presentation pathways in dendritic cells
- Rapamycin inhibits growth and survival of D816V-mutated c-kit mast cells
- United at last: the tuberous sclerosis complex gene products connect the phosphoinositide 3-kinase/Akt pathway to mammalian target of Rapamycin (mTOR) signalling
- Target of Rapamycin (TOR)-signaling and RAIP motifs play distinct roles in the mammalian TOR-dependent phosphorylation of initiation factor 4E-binding …
- … sunitinib (formerly SU11248) against a variety of human hematologic malignancies: enhancement of growth inhibition via inhibition of mammalian target of Rapamycin …
- Rapamycin attenuates atherosclerosis induced by dietary cholesterol in apolipoprotein-deficient mice through a p27Kip1-independent pathway
- Mammalian target of Rapamycin positively regulates collagen type I production via a phosphatidylinositol 3-kinase-independent pathway
- Human cytomegalovirus infection alters the substrate specificities and Rapamycin sensitivities of raptor-and rictor-containing complexes
- Regulation of Leucine Uptake by tor1+ in Schizosaccharomyces pombe Is Sensitive to Rapamycin
- TCR engagement increases hypoxia-inducible factor-1α protein synthesis via Rapamycin-sensitive pathway under hypoxic conditions in human peripheral T cells
- Early outcome after sirolimus-eluting stent implantation in patients with acute coronary syndromes: insights from the Rapamycin-Eluting Stent Evaluated At Rotterdam …
- Mammalian target of Rapamycin (mTOR) signaling is required for a late-stage fusion process during skeletal myotube maturation
- Local application of Rapamycin inhibits neointimal hyperplasia in experimental vein grafts
- Cyclin D1 and c-myc internal ribosome entry site (IRES)-dependent translation is regulated by AKT activity and enhanced by Rapamycin through a p38 MAPK …
- GATA factor translation is the final downstream step in the amino acid/target-of-Rapamycin-mediated vitellogenin gene expression in the anautogenous …
- Rapamycin attenuates atherosclerotic plaque progression in apolipoprotein E knockout mice: inhibitory effect on monocyte chemotaxis
- Rapamycin attenuates vascular wall inflammation and progenitor cell promoters after angioplasty
- Akt1/Akt2 and mammalian target of Rapamycin/Bim play critical roles in osteoclast differentiation and survival, respectively, whereas Akt is dispensable for cell …
- Fibronectin stimulates non–small cell lung carcinoma cell growth through activation of Akt/mammalian target of Rapamycin/S6 kinase and inactivation of LKB1/AMP …
- Activation of the phosphoinositide 3-kinase-Akt-mammalian target of Rapamycin signaling pathway is required for metabotropic glutamate receptor-dependent long …
- Rapamycin causes down-regulation of CCR5 and accumulation of anti-HIV β-chemokines: an approach to suppress R5 strains of HIV-1
- … in Parkinson brain substantia nigral neurons and mediates death in cellular models of Parkinson’s disease by a mechanism involving mammalian target of Rapamycin …
- Glucagon represses signaling through the mammalian target of Rapamycin in rat liver by activating AMP-activated protein kinase
- Isolation and Characterization of Pre‐Rapamycin, the First Macrocyclic Intermediate in the Biosynthesis of the Immunosuppressant Rapamycin by S. hygroscopicus
- Type D personality predicts death or myocardial infarction after bare metal stent or sirolimus-eluting stent implantation: a Rapamycin-Eluting Stent Evaluated at …
- A high-throughput method for screening of Rapamycin-producing strains of Streptomyces hygroscopicus by cultivation in 96-well microtiter plates
- Phosphatidic acid regulates systemic inflammatory responses by modulating the Akt-mammalian target of Rapamycin-p70 S6 kinase 1 pathway
- Comparative effects of paclitaxel and Rapamycin on smooth muscle migration and survival: role of AKT-dependent signaling
- Production of novel Rapamycin analogs by precursor-directed biosynthesis
- Rapamycin inhibits telomerase activity by decreasing the hTERT mRNA level in endometrial cancer cells1
- Effects of Rapamycin on number activity and eNOS of endothelial progenitor cells from peripheral blood
- Predictive and prognostic role of activated mammalian target of Rapamycin in cervical cancer treated with cisplatin-based neoadjuvant chemotherapy
- Insulin receptor substrate-2 proteasomal degradation mediated by a mammalian target of Rapamycin (mTOR)-induced negative feedback down-regulates …
- A Rapamycin derivative (everolimus) controls proliferation through down-regulation of truncated CCAAT enhancer binding protein β and NF-κB activity in Hodgkin and …
- Two motifs in the translational repressor PHAS-I required for efficient phosphorylation by mammalian target of Rapamycin and for recognition by raptor
- A nuclear transport signal in mammalian target of Rapamycin is critical for its cytoplasmic signaling to S6 kinase 1
- Regulation of B-Raf kinase activity by tuberin and Rheb is mammalian target of Rapamycin (mTOR)-independent
- … undergoing percutaneous intervention in the drug-eluting stent era: an integrated clinical and angiographic analysis based on the Rapamycin-Eluting Stent Evaluated …
- Antiangiogenic and immunomodulatory effects of Rapamycin on islet endothelium: relevance for islet transplantation
- Rapamycin mimics the incompatibility reaction in the fungus Podospora anserina
- Rapamycin effects transcriptional programs in smooth muscle cells controlling proliferative and inflammatory properties
- An open prospective pilot study on the use of Rapamycin after penetrating high-risk keratoplasty
- Ex vivo Rapamycin generates Th1/Tc1 or Th2/Tc2 Effector T cells with enhanced in vivo function and differential sensitivity to post-transplant Rapamycin therapy
- Post-transcriptional regulation of the androgen receptor by Mammalian target of Rapamycin
- Rapamycin induces apoptosis of JN-DSRCT-1 cells by increasing the Bax: Bcl-xL ratio through concurrent mechanisms dependent and independent of its …
- Efficacy of Rapamycin in patient with juvenile rheumatoid arthritis
- Mammalian target of Rapamycin (mTOR) regulates both proliferation of megakaryocyte progenitors and late stages of megakaryocyte differentiation
- Effects of Rapamycin on accumulation of α‐, β‐ and γ‐globin mRNAs in erythroid precursor cells from β‐thalassaemia patients
- Rapamycin and chronic kidney disease: beyond the inhibition of inflammation
- Overexpressed eIF4E is functionally active in surgical margins of head and neck cancer patients via activation of the Akt/mammalian target of Rapamycin pathway
- inhibition of the mammalian target of Rapamycin and the induction of cell cycle arrest in mantle cell lymphoma cells
- LY294002 and Rapamycin co‐operate to inhibit T‐cell proliferation
- The mTOR inhibitor Rapamycin down-regulates the expression of the ubiquitin ligase subunit Skp2 in breast cancer cells
- The immunosuppressant Rapamycin exacerbates neurotoxicity of Aβ peptide
- … transcriptionally and posttranslationally through phosphatidylinositol 3′-kinase/Akt, heat shock protein 90, and mammalian target of Rapamycin in transformed NK …
- From Rapa Nui to Rapamycin: targeting PI3K/Akt/mTOR for cancer therapy
- Evidence for down-regulation of phosphoinositide 3-kinase/Akt/mammalian target of Rapamycin (PI3K/Akt/mTOR)-dependent translation regulatory signaling pathways …
- Statins induce mammalian target of Rapamycin (mTOR)-mediated inhibition of Akt signaling and sensitize p53-deficient cells to cytostatic drugs
- Target of Rapamycin inhibitors (TOR‐I; sirolimus and everolimus) for primary immunosuppression in kidney transplant recipients
- Phophatidylinositol-3 Kinase/Mammalian Target of Rapamycin/p70S6K Regulates Contractile Protein Accumulation in Airway Myocyte Differentiation
- Amino acid signaling through the mammalian target of Rapamycin (mTOR) pathway: role of glutamine and of cell shrinkage
- Rapamycin: friend, foe, or misunderstood?
- Rapamycin inhibits growth of premalignant and malignant mammary lesions in a mouse model of ductal carcinoma in situ
- The product of the UTH1 gene, required for Bax‐induced cell death in yeast, is involved in the response to Rapamycin
- Effects of FK506 and Rapamycin on generation of reactive oxygen species, nitric oxide production and nuclear factor kappa B activation in rat hepatocytes
- Sustained intraocular Rapamycin delivery effectively prevents high-risk corneal allograft rejection and neovascularization in rabbits
- Effects of Rapamycin on the epithelial-to-mesenchymal transition of human peritoneal mesothelial cells
- Mammalian target of Rapamycin
- Rapamycin analogs for stent-based local drug delivery
- Handicapping the race to develop inhibitors of the phosphoinositide 3-kinase/Akt/mammalian target of Rapamycin pathway
- Differential effects of immunosuppressive drugs on chemokine receptor CCR7 in human monocyte-derived dendritic cells: selective upregulation by Rapamycin
- Mutations in the PI3K/PTEN/TSC2 pathway contribute to mammalian target of Rapamycin activity and increased translation under hypoxic conditions
- Rapamycin disrupts cyclin/cyclin-dependent kinase/p21/proliferating cell nuclear antigen complexes and cyclin D1 reverses Rapamycin action by stabilizing these …
- Mechanisms of action of Rapamycin in gliomas
- Enhancement of translation elongation in neurons by brain‐derived neurotrophic factor: Implications for mammalian target of Rapamycin signaling
- Oral Rapamycin to inhibit restenosis after stenting of de novo coronary lesions: the Oral Rapamune to Inhibit Restenosis (ORBIT) study
- Effects of combined treatment with Rapamycin and cotylenin A, a novel differentiation-inducing agent, on human breast carcinoma MCF-7 cells and xenografts
- Group I metabotropic glutamate receptors activate the p70S6 kinase via both mammalian target of Rapamycin (mTOR) and extracellular signal-regulated kinase (ERK …
- Rapamycin and tumor growth: mechanisms behind its anticancer activity
- inhibition of mammalian target of Rapamycin potentiates thrombin-induced intercellular adhesion molecule-1 expression by accelerating and stabilizing NF-κB …
- Insulin stimulates postsynaptic density-95 protein translation via the phosphoinositide 3-kinase-Akt-mammalian target of Rapamycin signaling pathway
- Modulation of insulin action by dietary proteins and amino acids: role of the mammalian target of Rapamycin nutrient sensing pathway
- Rituximab in association with Rapamycin for post-transplant lymphoproliferative disease treatment
- … macrophage colony-stimulating factor in neutrophils: cooperation of a MEK-related, THR421/SER424 kinase and a Rapamycin-sensitive, mTOR-related …
- Rapamycin‐mediated induction of γ‐globin mRNA accumulation in human erythroid cells
- Differing responses of Gat1 and Gln3 phosphorylation and localization to Rapamycin and methionine sulfoximine treatment in Saccharomyces cerevisiae
- Mammalian target of Rapamycin inhibitors in combination with letrozole in breast cancer
- … 4 on non-small cell lung cancer cells is regulated by the phosphatidylinositol 3-kinase/PTEN/AKT/mammalian target of Rapamycin signaling pathway and …
- Rapamycin does not induce anergy but inhibits expansion and differentiation of alloreactive human T cells
- Combination therapy of mycophenolate mofetil and Rapamycin in prevention of chronic renal allograft rejection in the rat1
- Rapamycin worsens renal function and intratubular cast formation in protein overload nephropathy
- Synergistic inhibition of human neuroblastoma-related angiogenesis by vinblastine and Rapamycin
- Rapamycin inhibits human renal epithelial cell proliferation: effect on cyclin D3 mRNA expression and stability
- … identified c-KIT receptor tyrosine kinase ITD in childhood AML induces ligand-independent growth and is responsive to a synergistic effect of imatinib and Rapamycin
- Gln3 phosphorylation and intracellular localization in nutrient limitation and starvation differ from those generated by Rapamycin inhibition of Tor1/2 in …
- Rapamycin preserves renal function compared with cyclosporine A after ischemia/reperfusion injury
- … -inducible factor-1 by the phosphatidylinositol 3-kinase/AKT/Ras homolog enriched in brain (Rheb)/mammalian target of Rapamycin (mTOR) pathway is …
- Superior T-cell suppression by Rapamycin and FK506 over Rapamycin and cyclosporine A because of abrogated cytotoxic T-lymphocyte induction, impaired memory …
- Estrogen-induced activation of mammalian target of Rapamycin is mediated via tuberin and the small GTPase Ras homologue enriched in brain
- … progesterone receptor expression in breast cancer cells via the phosphatidylinositol 3-kinase/Akt/mammalian target of Rapamycin pathway: progesterone receptor as …
- Acceleration of apoptosis in CD4+ CD8+ thymocytes by Rapamycin accompanied by increased CD4+ CD25+ T cells in the periphery1
- Intracellular network of phosphatidylinositol 3‐kinase, mammalian target of the Rapamycin/70 kDa ribosomal S6 kinase 1, and mitogen‐activated protein kinases …
- Interleukin-12-induced interferon-γ production by human peripheral blood T cells is regulated by mammalian target of Rapamycin (mTOR)
- Pilot study of oral Rapamycin to prevent restenosis in patients undergoing coronary stent therapy: Argentina Single-Center Study (ORAR Trial)
- … artery smooth muscle requires activation of phosphatidylinositol 3-kinase/serine-threonine protein kinase B/mammalian target of Rapamycin/p70 ribosomal S6 kinase …
- Interferon α-induced apoptosis in tumor cells is mediated through the phosphoinositide 3-kinase/mammalian target of Rapamycin signaling pathway
- ROS fusion tyrosine kinase activates a SH2 domain–containing phosphatase-2/phosphatidylinositol 3-Kinase/mammalian target of Rapamycin signaling axis to form …
- Hyperactivation of mammalian target of Rapamycin (mTOR) signaling by a gain-of-function mutant of the Rheb GTPase
- Oral Rapamycin inhibits growth of atherosclerotic plaque in apoE knock-out mice
- Rapamycin, an mTOR inhibitor, disrupts triglyceride metabolism in guinea pigs
- inhibition of insulin signaling and adipogenesis by Rapamycin: effect on phosphorylation of p70 S6 kinase vs eIF4E-BP1
- Stable expression of small interfering RNA sensitizes TEL-PDGFβR to inhibition with imatinib or Rapamycin
- Prolonged TCR/CD28 engagement drives IL-2-independent T cell clonal expansion through signaling mediated by the mammalian target of Rapamycin
- Insulin-like growth factor I-mediated protection from Rapamycin-induced apoptosis is independent of Ras-Erk1-Erk2 and phosphatidylinositol 3′-kinase-Akt signaling …
- Efficacy of polyphenon E, red ginseng, and Rapamycin on benzo (a) pyrene-induced lung tumorigenesis in A/J mice
- … of mTOR as a novel bifunctional target in chronic myeloid leukemia: dissection of growth‐inhibitory and VEGF‐suppressive effects of Rapamycin in leukemic cells
- Sustained activation of the mammalian target of Rapamycin nutrient sensing pathway is associated with hepatic insulin resistance, but not with steatosis, in …
- Rapamycin antagonizes NF-κB nuclear translocation activated by TNF-α in primary vascular smooth muscle cells and enhances apoptosis
- Rapamycin inhibits fibronectin-induced migration of the human arterial smooth muscle line (E47) through the mammalian target of Rapamycin
- Rapamycin (sirolimus) as a steroid-sparing agent in dermatomyositis
- Mammalian target of Rapamycin (mTOR) inhibitors
- Glucose-stimulated DNA synthesis through mammalian target of Rapamycin (mTOR) is regulated by KATP channels: effects on cell cycle progression in rodent …
- Targeting the AIB1 oncogene through mammalian target of Rapamycin inhibition in the mammary gland
- Activation of mammalian target of Rapamycin in transformed B lymphocytes is nutrient dependent but independent of Akt, mitogen-activated protein kinase/extracellular …
- Sirolimus-eluting stents remain superior to bare-metal stents at two years: medium-term results from the Rapamycin-Eluting Stent Evaluated at Rotterdam Cardiology …
- Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a Rapamycin-and farnesylation-dependent manner
- Rapamycin analogs with reduced systemic exposure
- Mammalian target of Rapamycin and protein kinase A signaling mediate the cardiac transcriptional response to glutamine
- Rapamycin decreases leukocyte migration in vivo and effectively reduces experimentally induced chronic colitis
- Exercise‐induced alterations in extracellular signal‐regulated kinase 1/2 and mammalian target of Rapamycin (mTOR) signalling to regulatory mechanisms of mRNA …
- Mechanistic insights into impaired dendritic cell function by Rapamycin: inhibition of Jak2/Stat4 signaling pathway
- Cyclin D3 is down-regulated by Rapamycin in HER-2-overexpressing breast cancer cells
- Rapamycin in children after liver transplantation
- inhibition of the phosphatidylinositol 3-kinase/mammalian target of Rapamycin pathway in hematologic malignancies
- Rapamycin and UCN-01 synergistically induce apoptosis in human leukemia cells through a process that is regulated by the Raf-1/MEK/ERK, Akt, and JNK signal …
- Activation of mammalian target of Rapamycin in postmenopausal ovarian endometriosis
- Fatal infection after Rapamycin eluting coronary stent implantation
- Effect of Rapamycin on the healing of the bile duct
- Rapamycin in lung transplantation
- Evidence for cyclin D3 as a novel target of Rapamycin in human T lymphocytes
- Rapamycin in combination with cyclosporine or tacrolimus in liver, pancreas, and kidney transplantation
- Lipase-catalyzed regioselective esterification of Rapamycin: synthesis of temsirolimus (CCI-779)
- Role of oral Rapamycin to prevent restenosis in patients with de novo lesions undergoing coronary stenting: results of the Argentina single centre study (ORAR trial)
- Structure-based design of AP23573, a phosphorus-containing analog of Rapamycin for anti-tumor therapy.
- Rapamycin inhibits proliferation of human neuroblastoma cells without suppression of MycN
- Rapamycin inhibits hTERT telomerase mRNA expression, independent of cell cycle arrest
- … of epidermal growth factor receptor/vascular endothelial growth factor receptor 2 (AEE788) and the mammalian target of Rapamycin (RAD001) offers improved …
- Ex vivo Rapamycin generates donor Th2 cells that potently inhibit graft-versus-host disease and graft-versus-tumor effects via an IL-4-dependent mechanism
- Studies investigating pretransplant donor-specific blood transfusion, Rapamycin, and the CD154-specific antibody IDEC-131 in a nonhuman primate model of skin …
- Early renal benefit of Rapamycin combined with reduced calcineurin inhibitor dose in pediatric heart transplantation patients
- inhibition of the phosphatidylinositol 3-kinase/Akt/mammalian target of Rapamycin pathway but not the MEK/ERK pathway attenuates laminin-mediated small cell lung …
- … Receptor Substrate-1 on Ser307 and Ser612 and Impairs the Phosphatidylinositol 3-Kinase/Akt/Mammalian Target of Rapamycin Insulin Biosynthetic Pathway in …
- Insulin facilitation of muscle protein synthesis following resistance exercise in hindlimb-suspended rats is independent of a Rapamycin-sensitive pathway
- The role of heme oxygenase 1 in Rapamycin-induced renal dysfunction after ischemia and reperfusion injury
- Rapamycin inhibits human in stent restenosis vascular smooth muscle cells independently of pRB phosphorylation and p53
- Synergistic growth inhibition by Iressa and Rapamycin is modulated by VHL mutations in renal cell carcinoma
- Perturbed IFN-γ-Jak-signal transducers and activators of transcription signaling in tuberous sclerosis mouse models: synergistic effects of Rapamycin-IFN-γ treatment
- Roles of phosphatidylinositol 3′-kinase and mammalian target of Rapamycin/p70 ribosomal protein S6 kinase in K-Ras-mediated transformation of intestinal epithelial …
- EFFECT OF Rapamycin ON THE FATE OF P23H OPSIN ASSOCIATED WITH RETINITS PIGMENTOSA (AN AMERICAN OPHTHALMOLOGICAL SOCIETY …
- Synergistic immunosuppressive effects of rosmarinic acid and Rapamycin in vitro and in vivo1
- Long-term islet allograft survival in nonobese diabetic mice treated with tacrolimus, Rapamycin, and anti-interleukin-2 antibody1
- Signaling interactions of Rapamycin combined with erlotinib in cervical carcinoma xenografts
- Rapamycin inhibits release of tumor necrosis factor-[alpha] from human vascular smooth muscle cells
- CD28 regulates the translation of Bcl-xL via the phosphatidylinositol 3-kinase/mammalian target of Rapamycin pathway
- Interaction of FoxO1 and TSC2 induces insulin resistance through activation of the mammalian target of Rapamycin/p70 S6K pathway
- Mammalian target of Rapamycin is required for thrombopoietin‐induced proliferation of megakaryocyte progenitors
- The fission yeast TOR proteins and the Rapamycin response: an unexpected tale
- Safety and pharmacokinetics of ascending single doses of sirolimus (Rapamune®, Rapamycin) in pediatric patients with stable chronic renal failure undergoing …
- Use of Rapamycin-impregnated stents in coronary arteries
- In Vivo and In Vitro Effects of SAR 943, a Rapamycin Analogue, on Airway Inflammation and Remodeling
- Farnesylthiosalicylic Acid Inhibits Mammalian Target of Rapamycin (mTOR) Activity Both in Cells and in Vitro by Promoting Dissociation of the mTOR-Raptor Complex
- Regulation of microtubule-dependent protein transport by the TSC2/mammalian target of Rapamycin pathway
- Pharmacokinetics of sirolimus (Rapamycin) in subjects with mild to moderate hepatic impairment
- Low-dose radiation plus Rapamycin promotes long-term bone marrow chimerism
- Rapamycin-coated expanded polytetrafluoroethylene bypass grafts exhibit decreased anastomotic neointimal hyperplasia in a porcine model
- Anti–third-party veto CTLs overcome rejection of hematopoietic allografts: synergism with Rapamycin and BM cell dose
- Combination of imatinib with Rapamycin or RAD001 acts synergistically only in Bcr-Abl-positive cells with moderate resistance to imatinib
- Outcomes of using Firebird Rapamycin eluting stents in routine coronary intervention practice: one-year results from the pilot study of Firebird in China registry
- Prolactin activates mammalian target-of-Rapamycin through phosphatidylinositol 3-kinase and stimulates phosphorylation of p70S6K and 4E-binding protein-1 …
- Modulation of collagen and MMP-1 gene expression in fibroblasts by the immunosuppressive drug Rapamycin: A direct role as an antifibrotic agent?
- Pmr1, a Golgi Ca2+/Mn2+-ATPase, is a regulator of the target of Rapamycin (TOR) signaling pathway in yeast
- Rapamycin ameliorates experimental autoimmune myocarditis
- First experience with Rapamycin-based immunosuppression to improve kidney function after heart transplantation
- Three-year clinical follow-up of the unrestricted use of sirolimus-eluting stents as part of the Rapamycin-Eluting Stent Evaluated at Rotterdam Cardiology Hospital …
- The mammalian target of Rapamycin-p70 ribosomal S6 kinase but not phosphatidylinositol 3-kinase-Akt signaling is responsible for fibroblast growth factor-9 …
- Differential effects of Rapamycin, cyclosporine A, and FK506 on human coronary artery smooth muscle cell proliferation and signalling
- Rapamycin causes activation of protein phosphatase-2A1 and nuclear translocation of PCNA in CD4+ T cells
- Rapamycin: a new string to the antiproteinuric bow?
- … the treatment of distal left main coronary artery disease in the drug-eluting stenting era. Clinical and angiographic insights into the Rapamycin-Eluting Stent Evaluated …
- Mammalian target of Rapamycin inhibitors in sarcomas
- Liposomal formulations of tacrolimus and Rapamycin increase graft survival and fiber outgrowth of dopaminergic grafts
- Rapamycin treatment is associated with an increased apoptosis rate in experimental vein grafts
- 5‐HT stimulates eEF2 dephosphorylation in a Rapamycin‐sensitive manner in Aplysia neurites
- Blockage of 2-deoxy-D-ribose-induced angiogenesis with Rapamycin counteracts a thymidine phosphorylase-based escape mechanism available for colon cancer …
- Rapamycin in lung transplantation: preliminary results
- Tsc1 haploinsufficiency without mammalian target of Rapamycin activation is sufficient for renal cyst formation in Tsc1+/− mice
- Novel sulfur-containing Rapamycin analogs prepared by precursor-directed biosynthesis
- Rapamycin inhibits Akt-mediated oncogenic transformation and tumor growth
- Synergistic inhibition of human melanoma proliferation by combination treatment with B-Raf inhibitor BAY43-9006 and mTOR inhibitor Rapamycin
- Akt and mammalian target of Rapamycin regulate separate systems of proteolysis in renal tubular cells
- … with targeted therapies against epidermal growth factor receptor/human epidermal growth factor receptor 2 and mammalian target of Rapamycin in breast cancer
- Mammalian target of Rapamycin regulates the growth of mammary epithelial cells through the inhibitor of deoxyribonucleic acid binding Id1 and their functional …
- The effect of Rapamycin on the healing of the ureteric anastomosis and wound healing
- Effect of SU11248 on gastrointestinal stromal tumor‐T1 cells: Enhancement of growth inhibition via inhibition of 3‐kinase/Akt/mammalian target of Rapamycin signaling
- Combination of a Rapamycin analog (CCI‐779) and interferon‐γ is more effective than single agents in treating a mouse model of tuberous sclerosis complex
- Overcoming T cell–mediated rejection of bone marrow allografts by T-regulatory cells: Synergism with veto cells and Rapamycin
- Routine sirolimus eluting stent implantation for unselected in-stent restenosis: insights from the Rapamycin eluting stent evaluated at Rotterdam Cardiology Hospital …
- Rapamycin inhibits liver growth during refeeding in rats via control of ribosomal protein translation but not cap-dependent translation initiation
- … is regulated by phosphorylation and turnover of protein kinase C βII mediated by phosphatidylinositol 3-kinase-and mammalian target of Rapamycin …
- Rapamycin rescue therapy in patients after kidney transplantation: first clinical experience
- Heme oxygenase-1 mediates the protective effects of Rapamycin in monocrotaline-induced pulmonary hypertension
- Successful treatment of a severe case of idiopathic pulmonary fibrosis with Rapamycin
- Evaluation of Rapamycin chemical stability in volatile-organic solvents by HPLC
- Characterization of the cloned full-length and a truncated human target of Rapamycin: activity, specificity, and enzyme inhibition as studied by a high capacity assay
- Rapamycin reduces neointima formation during vascular injury.
- Effects of aerobic exercise training on the protein kinase B (PKB)/mammalian target of Rapamycin (mTOR) signaling pathway in aged skeletal muscle
- Effects of Rapamycin on the arterial inflammatory response in atherosclerotic plaques in Apo-E knockout mice
- Effects of cyclosporin A and a Rapamycin derivative (SAR943) on chronic allergic inflammation in sensitized rats
- Rapamycin induces a caspase‐independent cell death in human monocytes
- Acute renal failure following kidney transplantation associated with myoglobinuria in patients treated with Rapamycin
- Rapamycin inhibits cdk4 activation, p 21WAF1/CIP1 expression and G1‐phase progression in transformed mouse fibroblasts
- Oral Rapamycin to prevent human coronary stent restenosis: a pilot study
- A downstream kinase of the mammalian target of Rapamycin, p70S6K1, regulates human double minute 2 protein phosphorylation and stability
- Rapamycin-resistant proliferation of CD8+ T cells correlates with p27kip1 down-regulation and bcl-xL induction, and is prevented by an inhibitor of …
- In rat hepatocytes glucagon increases mammalian target of Rapamycin phosphorylation on serine 2448 but antagonizes the phosphorylation of its downstream …
- Podospora anserina target of Rapamycin
- Mammalian target of Rapamycin and 3-phosphatidylinositol 3-kinase pathway inhibition enhances growth inhibition of transforming growth factor-β1 in prostate cancer …
- Actin cytoskeleton is required for nuclear accumulation of Gln3 in response to nitrogen limitation but not Rapamycin treatment in Saccharomyces cerevisiae
- Post-Rapamycin proteinuria: incidence, evolution, and therapeutic handling at a single center
- Farnesylthiosalicylic acid blocks mammalian target of Rapamycin signaling in breast cancer cells
- Prevention of lethal acute GVHD with an agonistic CD28 antibody and Rapamycin
- Effects of simian virus 40 large and small tumor antigens on mammalian target of Rapamycin signaling: small tumor antigen mediates hypophosphorylation of eIF4E …
- Rapamycin‐sensitive induction of eukaryotic initiation factor 4F in regenerating mouse liver
- Nutrient restriction differentially modulates the mammalian target of Rapamycin signaling and the ubiquitin-proteasome system in skeletal muscle of cows and their …
- The Saccharomyces cerevisiae phosphatase activator RRD1 is required to modulate gene expression in response to Rapamycin exposure
- Aortic eNOS expression and phosphorylation in Apo-E knockout mice: differing effects of Rapamycin and simvastatin
- Mammalian target of Rapamycin (mTOR) inhibition in chronic lymphocytic B-cell leukemia: a new therapeutic option
- … and activator of transcription-1 (STAT1)-dependent gene transcription by lipopolysaccharide and interferon-γ is regulated by mammalian target of Rapamycin
- The influence of the Rapamycin-derivate SDZ RAD on the healing of airway anastomoses
- Cilomilast, tacrolimus and Rapamycin modulate dendritic cell function in the elicitation phase of allergic contact dermatitis
- The impact of cyclosporine dose reduction with or without the addition of Rapamycin on functional, molecular, and histological markers of chronic allograft nephropathy
- Role of endothelin-1 and nitric oxide bioavailability in transplant-related vascular injury: comparative effects of Rapamycin and cyclosporine
- Characterization of a conserved C-terminal motif (RSPRR) in ribosomal protein S6 kinase 1 required for its mammalian target of Rapamycin-dependent …
- Mammalian target of Rapamycin is a promising target for novel therapeutic strategy against cancer.
- Effects of cyclosporin A, FK506 and Rapamycin on calcineurin phosphatase activity in mouse brain
- Both mitogen activated protein kinase and the mammalian target of Rapamycin modulate the development of functional renal proximal tubules in matrigel
- Activation of phosphatidylinositol 3-kinase, Akt, and mammalian target of Rapamycin is necessary for hypoxia-induced pulmonary artery adventitial fibroblast …
- Effects of Rapamycin on cardiac and skeletal muscle contraction and crossbridge cycling
- Frap, FKBP12 Rapamycin-associated protein, is a candidate gene for the plasmacytoma resistance locus Pctr2 and can act as a tumor suppressor gene
- Farnesyltransferase inhibitors reverse altered growth and distribution of actin filaments in Tsc-deficient cells via inhibition of both Rapamycin-sensitive and-insensitive …
- Modulation of translation‐initiation in CHO‐K1 cells by Rapamycin‐induced heterodimerization of engineered eIF4G fusion proteins
- Rapamycin antagonizes cyclosporin A‐and tacrolimus (FK506)‐mediated augmentation of linker for activation of T cell expression in T cells
- Activation of mammalian target of Rapamycin and the p70 S6 kinase by arsenic trioxide in BCR-ABL–expressing cells
- Proteomic analysis of anti‐angiogenic effects by a combined treatment with vinblastine and Rapamycin in an endothelial cell line
- The PCPH oncoprotein antagonizes the proapoptotic role of the mammalian target of Rapamycin in the response of normal fibroblasts to ionizing radiation
- Sirolimus (Rapamycin) monotherapy prevents graft vascular disease in nonhuman primate recipients of orthotopic aortic allografts
- Mammalian target of Rapamycin inhibitors in renal cell carcinoma: current status and future applications
- Investigating mammalian target of Rapamycin inhibitors for their anticancer properties
- Rapamycin treatment results in GATA factor-independent hyperphosphorylation of the proline utilization pathway activator in Saccharomyces cerevisiae
- The Rapamycin derivative RAD inhibits mesangial cell migration through the CDK-inhibitor p27 Kip1
- Combination therapy for treating breast cancer using antiestrogen, ERA-923, and the mammalian target of Rapamycin inhibitor, temsirolimus
- Generating Rapamycin analogues by directed biosynthesis: starter acid substrate specificity of mono-substituted cyclohexane carboxylic acids
- Electron microscopic and biochemical study of the effects of Rapamycin on glycogen autophagy in the newborn rat liver
- … 4H-1-benzopyran-4-one) acts via phosphatidylinositol 3-kinase-independent pathways to inhibit cell proliferation via mammalian target of Rapamycin (mTOR)-and non …
- Rapamycin in patients with chronic renal allograft dysfunction
- Regulation of the phosphatidylinositol 3-kinase, Akt/protein kinase B, FRAP/mammalian target of Rapamycin, and ribosomal S6 kinase 1 signaling pathways …
- … of metallothionein rescues chronic alcohol intake-induced cardiomyocyte dysfunction: role of Akt, mammalian target of Rapamycin and ribosomal p70s6 kinase
- Rapamycin inhibits E2F-dependent expression of minichromosome maintenance proteins in vascular smooth muscle cells
- Targeting metastatic leiomyosarcoma by Rapamycin plus gemcitabine: an intriguing clinical observation
- Vanadate and Rapamycin synergistically enhance insulin-stimulated glucose uptake
- Rapamycin control of transgene expression from a single AAV vector in mouse salivary glands
- Cutaneous leukocytoclastic vasculitis in a patient with myelodysplatic syndrome after therapy with the Rapamycin analogue everlimus: Case report and review of the …
- Determining sensitivity to Rapamycin and its analogues in breast cancer patients
- Rapamycin pre‐treatment preserves viability, ATP level and catabolic capacity during carbon starvation of Saccharomyces cerevisiae
- Rapamycin and FK506 reduce skeletal muscle voltage sensor expression and function
- Extracellular ATP-induced proliferation of adventitial fibroblasts requires phosphoinositide 3-kinase, Akt, mammalian target of Rapamycin, and p70 S6 kinase …
- The mTOR pathway in estrogen response: A potential for combining the Rapamycin derivative RAD001 with the aromatase inhibitor Letrozole (Femara®) in breast …
- inhibition of mammalian target of Rapamycin modulates expression of adhesion molecules in endothelial cells
- SUMO modification through Rapamycin-mediated heterodimerization reveals a dual role for Ubc9 in targeting RanGAP1 to nuclear pore complexes
- Cyclosporine and Rapamycin act in a synergistic and dose-dependent manner in a model of immunosuppressant-induced kidney damage
- Current Data with Mammalian Target of Rapamycin Inhibitors in Advanced Renal Cell Carcinoma
- Novel site‐specific systemic delivery of Rapamycin with perfluorobutane gas microbubble carrier reduced neointimal formation in a porcine coronary restenosis model
- The phosphatase subunit tap42 functions independently of target of Rapamycin to regulate cell division and survival in Drosophila
- Rapamycin control of exocrine protein levels in saliva after adenoviral vector-mediated gene transfer
- Farnesyltransferase inhibitors and Rapamycin in the treatment of multiple myeloma
- RACK1 mRNA translation is regulated via a Rapamycin-sensitive pathway and coordinated with ribosomal protein synthesis
- Mammalian target of Rapamycin promotes vincristine resistance through multiple mechanisms independent of maintained glycolytic rate
- Bone morphogenetic protein-2–induced transformation involves the activation of mammalian target of Rapamycin
- Rapamycin prolongs susceptibility of responding T cells to tolerance induction by CD8+ veto cells
- Current status of mammalian target of Rapamycin inhibitors in lung cancer
- Rapamycin inhibits vascular remodeling in an experimental model of allograft vasculopathy and attenuates associated changes in fibrosis-associated gene …
- Rapamycin and dendritic cells: keep on movin’
- Involvement of c-Jun NH2 terminal kinase and p38MAPK in Rapamycin-mediated inhibition of neointimal formation in rat carotid arteries
- Involvement of the VDE homing endonuclease and Rapamycin in regulation of the Saccharomyces cerevisiae GSH11 gene encoding the high affinity …
- Immunomodulatory effects of combination of pooled human gammaglobulin and Rapamycin on cell proliferation and apoptosis in the mixed lymphocyte reaction
- Six-month intravascular ultrasound follow-up of coronary bifurcation lesions treated with Rapamycin-eluting stents: technical considerations
- Trace analysis of Rapamycin in human blood by micellar electrokinetic chromatography
- Insulin-like growth factor binding protein-6 and CCI-779, an ester analogue of Rapamycin, additively inhibit rhabdomyosarcoma growth
- Differential translation of TOP mRNAs in Rapamycin-treated human B lymphocytes
- Rapamycin for androgen-independent prostrate cancer (AIPC)
- Rapamycin for cardiac transplant rejection and vasculopathy: one stone, two birds?
- Sirolimus and everolimus: inhibitors of mammalian target of Rapamycin in liver transplantation
- Rapamycin inhibits choroidal neovascularization
- Deletion of HOG1 leads to Osmosensitivity in starvation-induced, but not Rapamycin-dependent Atg8 degradation and proteolysis: Further evidence for different …
- Structure and function of mammalian target of Rapamycin [J]
- Comparison of Rapamycin and paclitaxel eluting stent in patients with multi-vessel coronary disease
- Retracted: Rapamycin Attenuates Liver Graft Injury in Cirrhotic Recipient—The Significance of Down‐Regulation of Rho‐ROCK‐VEGF Pathway
- Pharmacokinetics of Rapamycin-eluting stents in miniswine coronary model.
- Combination therapy with sirolimus (Rapamycin) and tacrolimus (FK-506) in treatment of refractory minimal change nephropathy, a clinical case report
- Combination of the mammalian target of Rapamycin (mTOR) inhibitor everolimus (E) with the insulin like growth factor-1-receptor (IGF-1-R) inhibitor NVP-AEW-541: A …
- Rapamycin and chronic lung rejection
- Synergistic suppression of rat neointimal hyperplasia by Rapamycin and imatinib mesylate: implications for the prevention of accelerated arteriosclerosis
- An intramolecular ionic hydrogen bond stabilizes a cis amide bond rotamer of a ring‐opened Rapamycin‐degradation product
- The effect of combined Rapamycin/cyclosporine on the changes in pro-fibrotic gene expression that occur during the development of allograft vasculopathy in rats …
- Modulation of tissue factor expression by Rapamycin and FK-506 in lipopolysaccharide-stimulated human mononuclear cells and serum-stimulated aortic smooth …
- Effect of Rapamycin on hepatic osteodystrophy in rats with portasystemic shunting
- Preclinical rationale for therapeutic targeting of mTOR by CC-I779 and Rapamycin in Hodgkin lymphoma
- Potential role of mammalian target of Rapamycin inhibitors in breast cancer therapy
- Altered centrosomes in ataxia‐telangiectasia cells and Rapamycin‐treated Chinese hamster cells
- Determination of Rapamycin: quantification of the sodiated species by an ion trap mass spectrometer as an alternative to the ammoniated complex analysis by triple …
- Nutritional studies on the growth of the Rapamycin-producing Streptomyces hygroscopicus
- A novel technique for on‐capillary preconcentration of anionic compounds applied to the trace analysis of Rapamycin in human blood by capillary electrophoresis
- … of the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor gefitinib in combination with the mammalian target of Rapamycin (mTOR) inhibitor everolimus …
- Glucose-induced binding of the polypyrimidine tract-binding protein (PTB) to the 3′-untranslated region of the insulin mRNA (ins-PRS) is inhibited by Rapamycin
- A phase I trial of gefitinib (ZD1839) plus Rapamycin for patients with recurrent malignant glioma
- Clinical use of Rapamycin in renal allograft recipients identifies its relevant toxicity profile and raises unsolved questions: a single-center experience
- Lung toxicity induced by Rapamycin
- Countervailing effects of Rapamycin (sirolimus) on nuclear factor-κB activities in neointimal and medial smooth muscle cells
- Dose-dependent inhibition of myointimal hyperplasia by orally administered Rapamycin
- Association of Rapamycin and co-stimulation blockade using anti-B7 antibodies in renal allotransplantation in baboons
- inhibition of growth and metastasis of hepatocellular carcinoma by Rapamycin: experiment with mice
- Cyclosporine A, FK-506, 40-0-[2-hydroxyethyl] Rapamycin and mycophenolate mofetil inhibit proliferation of human intrahepatic biliary epithelial cells in vitro
- Rapamycin inhibits platelet-derived growth factor-induced collagen, but not fibronectin, synthesis in rat mesangial cells
- A combination of anergic cells’ adoptive transfer and Rapamycin therapy prolongs cardiac allograft survival in mice
- Local application of Rapamycin inhibiting restenosis in experimental vein graft
- Negative regulation of interleukin-12 production by a Rapamycin-sensitive signaling pathway: a brief communication
- Rapamycin-based rescue therapy after chronic rejection in a pediatric liver transplant patient
- Altered trafficking of CD8+ memory T cells after implantation of Rapamycin-eluting stents in patients with coronary artery disease
- Rapamycin at six years can exhibit normal renal function without proteinuria or neoplasia after renal transplantation. A single-center experience
- Expression of placental mammalian target of Rapamycin (mTOR) is altered in relation to fetal growth and mTOR regulates leucine transport
- Regulation of hepatic insulin-like growth factor-binding protein-1 gene expression by insulin: central role for mammalian target of Rapamycin independent of forkhead …
- Rapamycin–a Potential Mechanistically Targeted Therapeutic for Juvenile Myelomonocytic Leukemia.
- In vivo and in vitro effect of CCI-779 a Rapamycin analogue on HNSCC.
- Pathologic assessment of cardiomyocytes in heart transplant recipients treated with Rapamycin or cyclosporine
- Pharmacodynamic-guided, modified continuous reassessment method (mCRM)-based, dose finding study of Rapamycin in adult patients with solid tumors
- Pharmacokinetics and safety of ABT-578, a sirolimus (Rapamycin) analogue, after single intravenous bolus injection in healthy male volunteers
- Rapamycin Inhibits Retinal and Choroidal Neovascularization in Mice
- In Vitro and In Vivo Antileukemic Effects of the mTOR-Targeting Drug Rapamycin in Patients with Imatinib-Resistant CML.
- Dual effects of Rapamycin on immuno-suppression and tumor inhibition
- Rapamycin inhibits the pathogenesis of posterior capsule opacification: experimental study on rabbit [J]
- Sphingosine-1-phosphate–induced smooth muscle cell migration involves the mammalian target of Rapamycin
- Phase I study of gefitinib and Rapamycin in patients with recurrent or progressive glioblastoma (Gbm)
- Rapamycin has no effect on fibrosis-associated gene expression or extracellular matrix accumulation when administered to animals with established or early …
- Effect of Rapamycin on cytokine profile in kidney transplant recipients treated with triple drug therapy
- Rapamycin as rescue therapy in a patient supported by biventricular assist device to heart transplantation with consecutive ongoing rejection
- Effect of Rapamycin on Phenotype of Vascular Smooth Muscle Cell and Arterial Intimal Hyperplasia Post Balloon Injury in Rat [J]
- Rapamycin plays a new role as differentiator of vascular smooth muscle phenotype. Focus on “The mTOR/p70 S6K1 pathway regulates vascular smooth muscle …
- … -up of the unrestricted use of the sirolimus-eluting stent compared to the use of a standard bare metal stent as part of the Rapamycin-Eluting-Stent Evaluated at …
- Observations on quadruple immunosuppression maintenance therapy using Rapamycin, low-dose cyclosporine, mycophenolate mofetil, and prednisone following …
- Mode of action of FK506 and Rapamycin
- Phase I study of Rapamycin (R) in combination with CYP3A4 modifier, ketoconazole (K), in patients with advanced malignancies
- Renal calcium handling after Rapamycin conversion in chronic allograft dysfunction
- Studies towards the synthesis of Rapamycin: Regiocontrol in the addition of carbanions to enantiomerically pure epoxides and the formation of a highly substituted …
- Rapamycin.
- Thrombosis caused by active Rapamycin stents
- Effect of Rapamycin and dexamethasone on differentiation and maturation of murine bone marrow-derived dendritic cells
- Comparison of Rapamycin versus FK506 on expression of cytoprotective genes in the rat kidney allografts undergoing chronic allograft nephropathy
- Why inhibitors of mammalian target of Rapamycin will be important in organ transplantation
- Stent release of a Rapamycin analogue: tissue pharmacokinetics of rapid versus delayed release
- Rapamycin: from the laboratory to the treatment of patients’ arteries
- Experimental study on the effects of Rapamycin in prevention of rat corneal allograft rejection
- Rapamycin overcomes multidrug resistance (MDR) mediated by P-glycoprotein (Pgp), Multidrug Resistance Protein-1 (MRP-1), Breast Cancer Resistance Protein …
- Complete assignments of the 1H and 13C resonances of 40‐epi‐(N1‐tetrazolyl)‐Rapamycin and revised 13C assignments for Rapamycin
- The Combination of the mTOR Inhibitor Rapamycin and Proteasome Inhibitor Bortezomib Is Synergistic In Vitro in Multiple Myeloma.
- Oral Rapamycin for the prevention of in-stent restenosis
- Rapamycin Enhances the Cytotoxicity of Bortezomib and Rituximab on Mantle Cell Lymphoma (MCL) Cell Lines.
- Surviving Rapamycin
- Lack of effect of Rapamycin in anti-CCP antibody production in a rheumatoid arthritis kidney allograft recipient
- Mammalian target of Rapamycin inhibitors in transplantation: novel immunosuppressive strategies with sirolimus
- Efficacy of Early Use of Rapamycin for Patients after Renal Transplantation and the Complications
- 1139-52 Biolimus A9: a new generation Rapamycin analogue inhibits intimal hyperplasia in a porcine model
- Rapamycin eluting stents
- Mammalian target of Rapamycin (mTOR) as a target in human breast cancer cells that have acquired resistance to aromatase inhibitor letrozole
- Rapamycin: sc-3504
- Investigation of Rapamycin and Rapamycin metabolites.
- Inhibitors of mammalian target of Rapamycin: mechanism of action explains efficacy and toxicity
- Rapamycin even when combined with cyclosporine attenuates tumor growth but does not induce regression of established walker sarcomas
- Sirolimus (Rapamycin) reduces the incidence of acute rejection episodes in renal transplantation: An initial experience in Taiwan
- Clinic application of Rapamycin-eluting stent for coronary heart disease [J]
- Intravitreal toxicity of Rapamycin
- Two-year experience with Rapamycin in kidney transplantation
- Safety and efficacy of sirolimus-eluting stent (cypher) in acute myocardial infarction: A substudy of the Rapamycin-Eluting Stent Evaluation at Rotterdam Cardiology …
- Sirolimus-eluting stents for treatment of in-stent restenosis in the real world: Preliminary results from the Rapamycin-Eluting Stent Evaluated at Rotterdam Cardiology …
- Rapamycin Combined with Cyclosporine in the Prevention of Acute Renal Allograft Rejection: Randomized Prospective Control Study
- Adverse effects of local or systemic application of Rapamycin for the prevention of neointimal hyperplasia
- Effect of combined regimen of Rapamycin and Cyclosporine on renal transplant recipients [J]
- Short-term Rapamycin for inhibition of neointima formation after balloon-mediated aortic injury in rats: is there a window of opportunity for systemic prophylaxis of …
- Pilot study with oral Rapamycin in patients undergoing stenting in coronary arteries: Buenos Aires experience (ORAR trial)
- CONTRASTING EFFECTS OF CYCLOSPORIN AND Rapamycin IN DE NOVO GENERATION OF ALLOANTIGEN-STIMULATED REGULATORY T CELLS.
- Combination of the mTOR inhibitor Rapamycin and HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin (17AAG) inhibits proliferation and induces apoptosis …
- Effects of Rapamycin-treated HSP60-pulsed dendritic cells on the progression of the atherosclerotic plaque in mice [J]
- Curcumin disrupts the complexes of the mammalian target of Rapamycin
- Review on Rapamycin as a potential therapeutic agent against neurodegenerative disease
- TOR (target of Rapamycin)-mediated regulation of translation
- Comparison of Different Therapies Of CYPHERTM Stent For Patients with Bifurcated Lesion Using Rapamycin
- Experimental study of effect of Rapamycin on proliferation of rat aortic smooth muscle cells
- Influence of CTLA4Ig combined with Rapamycin on the survival of renal allografts in rats [J]
- Local applied slow-releasing Rapamycin inhibits neointima hyperplasia in vein graft
- Rapamycin PREVENTS INTERSTITIAL FIBROSIS IN RENAL ALLOGRAFTS THROUGH DECREASING ANGIOGENESIS AND INFLAMMATION.
- … Regulatory (CD4+ CD25+ CD127LowFOXP3+) Cells to High Purity by Inhibiting Expansion of CD4+ CD25+ CD127HighFOXP3-Conventional T Cells with Rapamycin …
- Rapamycin impairs the healing of the ureteric anastomosis
- Effects of Rapamycin on the early development of zebrafish (Danio rerio)
- The combination of arsenic trioxide and Rapamycin has potent inhibitory effects on acute myeloid leukemia (AML) cells
- avb3-integrin-targeted paramagnetic nanoparticles deliver Rapamycin into the vascular wall and inhibit stenosis following balloon injury
- Treatment of lesions with a high risk of stenosis. comparative study in 300 patients of Rapamycin-and paclitaxel-eluting polymer-based stents, and bare metal stents
- Rapamycin Has Biological Activity in a Subset of Patients with Myelodysplastic Syndrome-Results of a Phase I/II Trial.
- Effect of Mycophenolic Acid and Rapamycin on the Proliferation of Glomerular Mesangial Cell of Rat
- Regulation of the mammalian target of Rapamycin complex 2 (mTORC2)
- Rapamycin NOT CYCLOSPORINE INDUCES REGULATORY CD8+ FOXP3+ CELLS.
- Comparison of the effects of Rapamycin-eluting stent implantation and coronary artery bypass grafting in treatment of patients with multi-vessel coronary disease
- Glucose-stimulated DNA Synthesis through Mammalian Target of Rapamycin (mTOR) Is Regulated by KATP Channels
- Subretinal sustained delivery of Rapamycin in the rabbit eye
- Constitutive Activation of Akt and mTOR by Flt3 Internal Tandem Duplications Mediates Myeloid Leukemogenesis and Can Be Inhibited by Rapamycin.
- Long-term clinical efficiency of endovascular treatment using Cypher Rapamycin-eluting stents in patients with coronary heart disease
- DOES Rapamycin EFFECT WOUND HEALING?
- Successful retransplantation using Rapamycin in a patient with previous calcineurin inhibitor-induced posterior leukoencephalopathy syndrome.
- Rapamycin inhibits the development of gallbladder adenocarcinoma in BK5. erbB2 transgenic mice
- Rapamycin disruption of mTOR-mLST8-raptor complex inhibits cell motility
- In vitro Rapamycin and costimulation generates Th1/Tc1 or Th2/Tc2 central memory effectors: Differential regulation by in vivo Rapamycin after allogeneic BMT
- Effect of combination of curcumin and Rapamycin on proliferation of rat glomerular mesangial cells
- Signaling by Target of Rapamycin Proteins
- Distinct mechanisms by which low and high Rapamycin doses raise plasma triglycerides in guinea pigs
- Everolimus: a classical mammalian target of Rapamycin inhibitor?
- Murine Ultrasonography Confirms That Rapamycin Is Effective Against Autoimmune Lymphoproliferative Syndrome (ALPS).
- STABILIZATION OF LONG-TERM PEDIATRIC RENAL ALLOGRAFTS WITH Rapamycin.
- A tissue selective Rapamycin analog inhibits MDA-MB-231 breast cancer cell-induced osteolytic bone metastases in nude mice
- Rapamycin throws a master switch.
- Rapamycin-CUSTOMIZED DENDRITIC CELLS ARE RESISTANT TO MATURATION INDUCED BY CD40 LIGATION—A CONDITION PIVOTAL TO THEIR …
- USE OF Rapamycin IN CHILDREN POST LIVER TRANSPLANTATION
- Mammalian Target of Rapamycin inhibition Synergistically Increases Cytotoxicity of Vinorelbine in Breast Cancer Cells.
- The role of caspase-3 in Rapamycin-induced apoptosis of hepatocellular carcinoma BEL-7402 cells
- Enhanced Killing of Chronic Myelogenous Leukemia Cells by Rapamycin and Imatinib Is Associated with Differential inhibition of 4E-BP1 and eIF4E Phosphorylation …
- Rapamycin Induces Balb/C Murine CD4+CD25+Foxp3+ T Cells Proliferations.
- Effect of locally administered Rapamycin and cyclosporin A on penetrating keratoplasty rejection rat model
- Curcumin inhibits the mammalian target of Rapamycin-mediated signaling pathways
- Bone-targeted Rapamycin analogs inhibit osteolysis and tumor growth in a PC-3-GFP intratibial bone cancer model in nude mice
- The expression of mammalian target of Rapamycin and its substrates in autogenous vein graft in rats
- Effects of Rapamycin on Notch1/Jagged1 signal pathway and the expression of fibronectin in TGF-β, induced rat renal intertitial fibroblasts [J]
- The mTOR Inhibitor Rapamycin Inhibits Drug Transport in Multidrug Resistant Cell Lines and in Acute Myeloid Leukemia (AML) Cells.
- Effect of Rapamycin on Corneal Neovascularization
- THE EFFECT OF Rapamycin ON BILE DUCT HEALING
- Safety and efficacy comparison between Rapamycin-eluting stent with biodegradable polymer or permanent polymer in patients with coronary artery disease
- Rapamycin added to human CD25+ cell cultures activated through CD3/CD28 enriches for CD4+ CD25+ CD27+ Foxp3+ regulatory T cells
- Effect of Mycophenolic Acid and Rapamycin on the Proliferation and Collagen Synthesis of the Vascular Smooth Muscle Cell of Rat
- Two-year experience with Rapamycin in kidney transplantation
- Effects of Rapamycin on the function of human dendritic cells
- Effects of Rapamycin on Rho-kinase and p27 mRNA expressions in a porcine coronary intimal proliferation model induced by interleukin-1beta
- IN CONTRAST TO CYCLOSPORIN, Rapamycin SPARES FOXP3+ CD4+ T-CELLS IN VIVO.
- Rapamycin THERAPY IN PANCREAS ALLOGRAFT RECIPIENTS
- Sustained Rapamycin drug delivery system in prevention of high risk corneal allograft rejection and neovascularization in rabbits
- The role of GSK3β in Rapamycin-mediated cell cycle regulation
- Rapamycin Treatment Results in GATA
- Possible molecular target therapy with Rapamycin in MDS
- Blocking mTOR by Rapamycin reduces HIF-1α function in human gastric cancer cells in vitro and inhibits angiogenesis and tumor growth in vivo
- Influence of CTLA4Ig combined with Rapamycin on the survival of renal allografts in rats
- Combination therapy of bevacizumab with Rapamycin in antitumor activity.
- EVALUATION OF APOPTOSIS IN PERIPHERAL HUMAN LYMPHOCYTES EXPOSED TO Rapamycin.
- … IN CHRONIC ALLOGRAFT NEPHROPATHY (CAN) FOLLOWING CALCINEURIN INHIBITORS (CNI) WITHDRAWAL AND CONVERSION TO Rapamycin.
- Application of Rapamycin in the patients with liver injury following renal transplantation: a report of 7 cases
- Establishment of a Rapamycin-resistant cell line that retains sensitivity to PI3 kinase inhibitors.
- mTOR (mammalian target of Rapamycin) inhibition with RAD001 induces cell cycle arrest in diffuse large B cell lymphoma (DLBCL) cells and sensitizes DLBCL cells to …
- A Novel Serum-Stable Micelle System for Controlled Release of Rapamycin
- The effects of Rapamycin for the chole-sterol rabbits after balloon injury
- Effect of New Immunosuppressant-Rapamycin on One-Way Mixed Lymphocyte Culture
- inhibition of repopulation is not a determining factor for the radiosensitizing effects of Rapamycin
- Antitumor efficacy of Rapamycin derivertive RAD001 in human ovarian cancer
- Dendritic cells, Rapamycin and transplant tolerance
- Troglitazone Exerts a Cell-Dependent Effect on the Extracellular Secretion of VEGF165 Independently from the Rapamycin Sensitivity or the Level of eIF4E …
- Rapamycin inhibited the growth of hepatocellular carcinoma in nude mice
- Rapamycin-Eluting Stents for the Treatment of In-Stent Restenosis
- Effect of Rapamycin on Renal Ischemia Reperfusion Injury
- Mutant type glutathione S-transferase theta 1 gene homologue to mTOR in myelodysplastic syndrome: possible clinical application of Rapamycin
- A RARE CASE OF Rapamycin INDUCED SECRETORY DIARRHEA IN A LIVER TRANSPLANT PATIENT: 544
- Clinical application of domestic Rapamycin-eluting stents in coronary heart disease patients
- The Studies of Antitumor Effect of Rapamycin on Human Hepatocellular Carcinoma BEL-7402 Cells in vitro
- Investigation of the Function and Regulatory Mechanisms of the Mammalian Target of Rapamycin
- New progress of Rapamycin in prevention and treatment of chronic allograft nephropathy
- Mammalian Target of Rapamycin (mTOR)
- Rapamycin treatment during fractionated radiotherapy causes cell death in 3D culture
- 18F-Labeled analog of Rapamycin for PET imaging
- Rapamycin-SENSITTVE SIGNAL TRANSDUCTION PATHWAYS AND THE CONTROL OF ADIPOGENESIS
- Therapeutic effect of Rapamycin in the treatment of malignancies in recipients after kidney transplantation
- Sirolimus (Rapamycin) impairs renal function
- Rapamycin INHIBITS NK CELL FUNCTION
- … WITH THYMOGLOBULIN/ZENAPAX INDUCTION, TACROLIMUS AND STEROID MAINTENANCE, COMPARING Rapamycin WITH MYCOPHENOLATE MOFETIL …
- Rapamycin modifies the vascular tone of rat isolated aortas
- Rapamycin-INDUCED PROTEINURIA: INCIDENCE, OUTCOME AND THERAPEUTIC HANDLING.
- Prolonged survival of renal allografts with domestic Rapamycin in rats [J]
- … FUNCTIONS OF REGULATORY T CELLS, LEADING, IN CONJUNCTION WITH A BRIEF SUB-THERAPEUTIC COURSE OF Rapamycin, TO ROBUST, DONOR …
- Clinical Benefits of Rapamycin-Eluting Stent Implantation in Patients With Acute Coronary Syndromes
- The role of phosphorylation in the regulation of the mammalian target of Rapamycin.
- The clinical effect of homemade Rapamycin-eluting stent on acute myocardial infarction
- Regulation of skeletal muscle differentiation by a Rapamycin-sensitive signaling pathway
- THE MAMMALIAN TARGET OF Rapamycin (mTOR) AS A TARGET FOR CANCER CHEMOTHERAPY
- Combination therapy targeting hypoxia inducible factor-α (HIF-1 α) and Tissue Factor (TF) by the mTOR inhibitor Rapamycin and the histone deacetylase inhibitor …
- Rapamycin is efficacious against gliomas and acts as an anti-VEGF and anti-invasion agent
- DIFFERENT FUNCTIONAL, HISTOLOGICAL AND INMUNOHISTOCHEMICAL PATTERNS INDUCED BY THE ASSOCIATION OF Rapamycin WITH FK506 OR …
- Orally Administered Rapamycin Can Inhibit Myointimal Hyperplasia: Should It Be Used?
- Effects of Rapamycin-eluted stent on platelet function in patients with coronary heart disease
- Regulation of the GATA-type transcription factor Gln3p by the target of Rapamycin protein (TOR).
- Combination of Rapamycin and somatostatin analogues for the treatment of nonfunctioning pituitary tumors
- The experimental study on the effects of Rapamycin and statin on chronic transplant vasculopathy
- Rapamycin targets Cyclin/Cdk/p21/PCNA complexes and Cyclin D1 reverses Rapamycin action by stabilizing these complexes
- Rapamycin conversion for immunosuppressive therapy in the setting of renal insufficiency in patients with heart transplantation: pilot observations
- Inhibitory Effect of Rapamycin on Corneal Neovascularization induced by Angiogenin in Rabbits
- NURSING IMPLICATIONS REGARDING THE MANAGEMENT OF SIDE EFFECTS IN A PHASE I STUDY USING GEFITINIB WITH Rapamycin.
- Clinical Contrast Investigation of Rapamycin Eluting Stent between Chinese Making and Imported
- The role of mammalian target of Rapamycin (mTOR) in a rat model of autoimmune myocarditis
- Effect of Rapamycin on Mouse Chronic Lymphocytic Leukemia and the Development of Nonhematopoietic Malignancies in Em-TCL1 Transgenic Mice
- Overview of Therapeutic Potential of Rapamycin for Coronary Artery Diseases in the Era of the Drug-Eluting Stent
- Rapamycin-Sensitive Signal Transduction Pathways and the Control of Adipogenesis
- Rapamycin for Cardiac Transplant Rejection and Vasculopathy
- Rapamycin synergistically enhances the cytotoxicity of paclitaxel in breast cancer cells
- Oral Rapamycin attenuates progression of atherosclerotic plaque in ApoE knockout mice
- Clinical Research of Rapamycin-Eluting Stent in Treatment of Multi-Vessel Coronary Disease
- Rapamycin inhibits expression of minichromosome maintenance proteins in vascular smooth muscle cells
- Biocompatibility of Rapamycin-Batroxobin Eluting Stent in Porcine Coronary Artery
- Effect of Rapamycin on anti-HLA donor antibody formation in patients with transplant coronary artery disease
- Combination of the mTOR Inhibitor Rapamycin and Revlimid™(CC-5013) Has Synergistic Activity in Multiple Myeloma (MM).
- Characterization of the FKBP·Rapamycin·FRB Ternary Complex [J. Am. Chem. Soc. 2005, 127, 4715−4721].
- Is there a role for oral Rapamycin in restenosis prevention after bare-metal stent implantation?
- Isolation and Genetic Analysis of Rapamycin-sensitive mutants in Aspergillus nidulans.
- Overexpression of the Bad mutant (S112A) partially disrupts the ability of IGF-I to protect cells from Rapamycin-induced apoptosis
- One year effect of Rapamycin eluting stent in patients with coronary heart disease
- The role of mammalian target of Rapamycin (mTOR) in insulin resistance
- Rapamycin AND SANGLIFEHRIN A CAN INHIBIT INTERLEUKIN-18 PRODUCTION FROM DENDRITIC CELLS IN VITRO AND IN VIVO.
- MRI detection of Rapamycin and AP-Cav therapeutic rescue from endothelial over expression of Akt in transgenic mice
- SENSITIVITY OF HUMAN METASTATIC MELANOMA CELLS TO THE ESTER ANALOG OF Rapamycin, CCI-779
- Synergistic growth inhibition by Iressa and Rapamycin in Renal Cell Carcinoma (RCC) with wild-type VHL
- Six-month results of a biodegradable polymer and Rapamycin-coating stent for coronary artery disease
- The mTOR inhibitor, Rapamycin, inhibits growth of Ewing’s sarcoma in vitro and in vivo
- EEEICACY AND SAFETY OF Rapamycin-BASED IMMUNOSUPPRESSION REGIMEN WITH OR WITHOUT CSA IN RENAL TRANSPLANTATION: A SYSTEMATIC …
- Rapamycin Inhibits Rabbit Corneal Neovascularization Induced by Angiogenin
- Preclinical analysis of Rapamycin plus EGFR or MEK1/2 inhibitors in renal cell carcinoma (RCC)
- Effect of Rapamycin (RPM) on interleukin-10 gene expression in rats with postburn Staphylococcus aureus sepsis
- Effect of Rapamycin on mouse CLL and development of non-hematopoietic malignancies in Eμ-TCL1 transgenic mice
- Effect of isoflavones alone and in combination with Rapamycin on mTOR pathway in human glioblastoma cells (U87).
- Rapamycin INHIBITS THE SPONTANEOUS FORMATION OF DE NOVO CANCER IN P53 KNOCKOUT MICE.
- Urokinase-induced smooth muscle cell migration involves the mammalian target of Rapamycin
- Importance of mammalian target of Rapamycin inhibitors in the prevention of cardiac allograft vasculopathy
- Rapamycin enhances the number and function of alloantigen-induced human CD103+CD8+ regulatory T cells in vitro
- Clinical contrast investigation of Rapamycin eluting stent between Chinese making and imported in the treatment of coronary artery disease
- Rapamycin inhibits activation of STAT3 in renal tissue of IgA nephropathy rats
- The mTOR inhibitor Rapamycin inhibits proadhesive activity of arterial intimal smooth muscle cells
- Identification of a highly effective Rapamycin schedule that markedly reduces the size, multiplicity and phenotypic progression of tobacco carcinogen-induced murine …
- Mammals Target Protein of Rapamycin (mTOR) Expression in Adult Acute Myeloid Leukemia Patients
- A Randomized Comparison Between Paclitaxel-Eluting Stents and Rapamycin-Eluting Stents for Patients With Coronary Artery Diseases
- Silencing mTOR signal by small interfering RNA enhances Rapamycin-induced autophagy in malignant glioma cells.
- CYCLOSPORINE AND Rapamycin ACT IN A SYNERGISTIC AND DOSE-DEPENDENT MANNER IN A MODEL OF IMMUNOSUPPRESSANT-INDUCED KIDNEY …
- The role of the mammalian target of Rapamycin (mTOR) in long term potentiation
- Nursing intervention of chronic renal diseases patients orally taking Rapamycin after underwent kidney transplantation [J]
- The effect of Rapamycin after cyclosporin dose reduction on chronic allograft nephropathy
- The Saccharomyces Cerevisiae Phosphatase Activator YPTPA1/RRD1 is Required to Modulate Gene Expression in Response to Rapamycin Exposure
- COMBINATION OF Rapamycin PLUS MUTANT TGF-b/Fc TO INDUCE IMMUNE TOLERANCE.
- Effect of Akt (PKB) on the activity of mammalian target of Rapamycin (mTOR)
- Effect of Rapamycin Eluting Stent on Level of C-reactive Protein in Patients with Acute Coronary Syndrome After Angioplasty [J]
- PI3K and mTOR signalling pathways: perspectives for Rapamycin and its derivatives as antineoplastic targeted therapies
- Effectiveness and safety of Rapamycin-based immunosuppression regimens on preserving or withdrawing CsA in renal transplantation: a systematic review
- The modulation of neointimal proliferation and p27 kip expression after implanting Rapamycin-eluting stents in the porcine coronary model
- Different released Rapamycin eluting stents to reduce in-stent neointimal hyperplasia in a porcine coronary model
- CHIMERISM PLAYS AN ACTIVE ROLE IN TRANSPLANTATION TOLERANCE INDUCED BY ALS, Rapamycin AND DONOR BONE MARROW INFUSION
- Effect of Biodegradable Rapamycin-Eluting Stent on Neointimal Proliferation in Porcine Coronary Artery Model
- Rapamycin INHIBITS IL-10 INDUCTION BY LATENT MEMBRANE PROTEIN 1 OF EPSTEIN BARR VIRUS.
- Editorial [Hot Topic: Mammalian Target of Rapamycin as a Therapeutic Target in Leukemia (Executive Editors: Francis J. Giles/Maher Albitar)]
- A Gene Expression Connectivity Map Identifies Rapamycin as a Glucocorticoid Resistance Reversal Agent in Lymphoblastic Leukemia.
- Rapamycin-sensitive TOR signaling regulates intestinal growth and morphogenesis in zebrafish
- TARGET OF Rapamycin (TOR) MEDIATES THE ENDODERM-INTESTINE TRANSITION IN ZEBRAFISH: 68
- Lactic-co-glycolic acid polymer with Rapamycin coated stent reduces neo-intimal formation in a porcine coronary model
- The mammalian target of Rapamycin controls cell motility through its effectors S6K1 and 4E-BP1
- SAFETY AND EFFICACY OF A STEROID-FREE REDUCED-DOSE NEORAL/Rapamycin MAINTENANCE IMMUNOSUPPRESSION IN RENAL TRANSPLANTATION …
- inhibition of mTOR signaling with Rapamycin attenuates renal hypertrophy in the early diabetic mice
- Combinations of Cytotoxic Drugs, Ionizing Radiation, and Mammalian Target of Rapamycin (mTOR) Inhibitors
- Effects of stent-based delivery of Rapamycin and methotrexate on neointimal formation in a porcine coronary model
- Rapamycin MANIPULATION OF HOST-DERIVED, ALLOANTIGEN-PULSED DENDRITIC CELLS PLUS POSTOPERATIVE Rapamycin, BUT NOT FK506 …
- Ex Vivo Rapamycin Generates Th2 Cells with Enhanced Mitochondrial Function and Reduced Apoptosis Via Intrinsic and Extrinsic Pathways.
- combination with the immunosuppressive drug Rapamycin, seems to forestall rejection in mice. Transferring this protocol to the human clinic should be fairly straight …
- Rapamycin-generated CD4+, Th2 cells modulate graft-versus-host reaction via an IL-4 dependent mechanism
- The assessment of human islets for transplantation and the effect of the immunosuppressant Rapamycin on MIN-6 cells, rat and human islets
- 549: The Effect of Rapamycin Immunosuppression on Native Polycystic Kidney Volumes in Renal Transplant Patients
- Calcineurin inhibitors but not Rapamycin abrogate activation of the immunomodulatory enzyme indoleamine 2, 3-dioxygenase.
- Translational control of gene expression in rat liver in relation to mammalian target of Rapamycin signaling
- Rapamycin Protects Allografts From Rejection While Simultaneously Attacking Tumors in Immunosuppressed Mice
- Rapamycin and IL-10 induce Ag-specific T regulatory type 1 cells (Tr1) and b-islet allograft tolerance in diabetic mice
- In Vitro and in Vivo Cyclosporine-Induced Tumor Angiogenesis and Tumor Growth Are Blocked By Simultaneous Application of Rapamycin
- Rapamycin INHIBITS EPSTEIN BARR VIRUS+ B CELL LYMPHOMA THROUGH MODULATION OF CELL CYCLE PROTEIN EXPRESSION.
- Newly identified kit ITD in childhood AML induces ligand independent growth and is responsive to a synergistic effect of imatinib and Rapamycin
- Effects of the immunomodulatory drugs tacrolimus, Rapamycin and cilomilast on dendritic cell function in a model of allergic contact dermatitis
- Rapamycin exerts an anti-inflammatory action in vitro and in vivo by inducing monocyte apoptosis and modulating cytokine/chemokines secretion
- Site specific systemic delivery of Rapamycin with perfluorobutane gas microbubble carrier reduced neointimal formation in the porcine coronary restenosis model
- Rapamycin sensitizes tumor cells to chemotherapy-induced apoptosis and induces cell cycle arrest in ALK+ anaplastic large cell lymphoma.
- Sustained Rapamycin Drug Delivery System for Prevention of High Risk Corneal Allograft Rejection and Neovascularization in Rabbits
- Everolimus Is Comparably Effective to Rapamycin Acting Synergistically with Imatinib in the Treatment of Constitutively Active Mutations of the Juxtamembrane …
- Unrestricted Utilization of Sirolimus-Eluting Stents in the “Real World”: The Rapamycin-Eluting Stent Evaluated At Rotterdam Cardiology Hospital …
- Serotonin-mediated activation of Rapamycin-sensitive S6 kinase-S6 ribosomal protein signal transduction pathway in synaptosomes.
- Rapamycin INHIBITS EPSTEIN BARR VIRUS+ B CELL LYMPHOMA PROLIFERATION THROUGH MODULATION OF CELL CYCLE PROTEIN EXPRESSION.
- Effects of Rapamycin Eluting Stents on Blood Tissue Factor and Tissue Factor Pathway Inhibitor in Patients With Acute Coronary Syndromes
- DONOR SPECIFIC TRANSFUSION COMBINED WITH Rapamycin PROLONGED THE CARDIAC GRAFT SURVIVAL IN MICE.
- Activity of panitumumab plus Rapamycin against wild type (WT) and mutant epidermal growth factor receptor (EGFr)-expressing NSCLC xenografts
- TACROLIMUS DECREASES, CYCLOSPORINE INCREASES, AND Rapamycin HAS NO EFFECT ON PROFIBROTIC GENE MRNA EXPRESSION IN RENAL …
- Rapamycin Generated Murine Th2/Tc2 Cells Potently Abrogate Fully MHC-Mismatched Hematopoietic Stem Cell (HSC) Graft Rejection.
- 548: inhibition of the mTOR Pathway by Rapamycin Reverses Renal Cystogenesis in Polycystic Kidney Disease Models
- The mTOR inhibitor Rapamycin inhibits p27 protein degradation by downregulating the expression of its ubiquitin ligase Skp2 in breast cancer
- Induction of apoptosis in Ewing’s Sarcoma cells by simultaneous treatment with antisense oligodeoxynucleotides (AS-ODNs) to the EWS/FLI-1 gene and Rapamycin
- Construction of eukaryotic expression vector of mammalian target of Rapamycin antisense RNA and its expression in vascular smooth muscle cell
- INFLUENCE OF IMMUNOPHILLINS INHIBITORS–CYCLOSPORINE-A, TACROLIMUS AND Rapamycin–ON INSULIN SECRETION IN HEART TRANSPLANT …
- Targeting the ICOS-B7h Costimulatory Pathway Synergizes with Rapamycin to Regulate Alloresponses in Islet Transplantation: 0102
- Short and long-term therapeutic effects of Rapamycin-eluting stent and paclitaxel-eluting stent in treatment of coronary disease with complicated lesions
- The Immunomodulatory Agent Rapamycin Potentiates the Antiviral Activity of the Fusion Inhibitor T20 Against R5 Strains of HIV-1
- Binding of mTOR (Mammalian Target of Rapamycin) to the Raptor-eIF4E-4EBP1 complex changes during myogenic differentiation.
- COMBINATION OF Rapamycin AND ANTI-LFA-1 PREVENTS REJECTION OF RAT ISLET XENOGRAFTS.: 042
- Hypoxia and Rapamycin induced changes to the cell cycle of multicellular spheroids and human tumour xenografts leading to potential therapeutic advantage
- 1853: A Propsective Study With Thymoglobulin/Daclizumab Induction, Tacrolimus and Steroid Maintenance, Comparing Rapamycin With Mycophenolate Mofetil as …
- Anti-angiogenic and immunomodulatory effects of Rapamycin on pancreatic islet endothelial cells: relevance for islets engraftment after transplantation
- A comparison study on FTY720, 40-O-(2-hydroxyethyl)-Rapamycin and cyclosporine to prolong the survival of mouse heart allograft
- Role of p53 in TRAIL-induced apoptosis in glioblastoma multiforme and modulation by taxol, Rapamycin or temozolomide
- DIFFERENTIAL EFFECT OF CALCINEURIN INHIBITORS, ANTI-CD25 ANTIBODIES AND Rapamycin ON THE INDUCTION OF FOXP3 IN HUMAN T-CELLS IN VIVO …
- … mechanisms regulating proliferation, antigen responsiveness, and differentiation of CD4⁺ T lymphocytes: a central role for the mammalian target of Rapamycin (mTOR …
- Overexpression of a critical target of Rapamycin, translation regulatory protein 4E-BP1, is largely restricted to locally advanced breast and prostate cancers and is lost …
- Receptor activator of NF-kB (RANK) and its ligand RANK-L coincide with expression of Rapamycin receptor FKBP12 in neointimal dendritic cells
- The PI3K inhibitor LY294002 and the mTOR inhibitor Rapamycin sensitize melanoma cells to cisplatin and temozolomide
- Rapamycin and Anti-LFA-1 Monoclonal Antibody Prevent the Rejection of Rat Islet Xenografts and Induce Tolerance in BALB/c Mice
- Glucagon Represses Insulin Signaling through Mammalian Target of Rapamycin (mTOR) in Perfused Rat Liver
- MYCOPHENOLATE MOFETIL (MMF)/Rapamycin (RAPA) COMPARED TO OTHER COMMON IMMUNOSUPPRESSIVE REGIMENS IN KIDNEY …
- Ras Homologue Enrich in Brain (Rheb) Enhances Hypertrophic Response via the Mammalian Target of Rapamycin (mTOR)/p70S6K Pathway
- … OF HUMAN BONE MARROW DERIVED MESENCHYMAL PROGENITORS—A SIGNAL TRANSDUCTION BASE FOR PLEIOTROPY OF Rapamycin DERIVATES.
- grammed autophagy in the fat body during the final larval stage. TOR (target of Rapamycin) kinases, the central components of a conserved nutri-ent-sensing …
- ANTI-CD25 MAB, ANTI-IL2 MAB AND IL2 BLOCK TOLERANCE INDUCTION THROUGH ANTI-CD154 MAB AND Rapamycin IN XENOGENEIC ISLET …
- Schedule-dependent activity of combined epidermal growth factor receptor (EGFR) and mammalian target of Rapamycin (mTOR) targeting in PTEN negative breast …
- Differential effects of the immunosuppressive agents cyclosporine A, Rapamycin and FK-506 on drug transport by the ATP-binding cassette (ABC) proteins P …
- Amino acid transporter ASCT2 expression regulates mammalian Target‐of‐Rapamycin (mTOR) growth and survival signaling in human hepatoma cells
- … WITHDRAWAL (PW) TRIAL IN KIDNEY TRANSPLANT PATIENTS TREATED WITH MYCOPHENOLATE SODIUM (MS) COMPARING Rapamycin® VS. C2 DOSED …
- Rapamycin AND ANTI-LFA-1 THERAPY MEDIATE ISLET GRAFT SPECIFIC TOLERANCE IN CONCORDANT XENOGENEIC ISLET TRANSPLANTATION.
- PHARMACOKINETICS OF ONCE A DAY DOSE OF CYCLOSPORINE IN COMBINATION WITH Rapamycin AND PREDNISONE IN RENAL TRANSPLANTATION IN …
- ROLE OF THE MAMMALIAN TARGET OF Rapamycin IN THE REGULATION OF SKELETAL MUSCLE PROTEIN SYNTHESIS AND eIF2B EPSILON mRNA …
- IGF-1 rescues Rapamycin-induced cell growth inhibition
- CONCOMITANT USE OF CYCLOSPORINE-A (CyA) AND Rapamycin (RAPA) WITH A CONSECUTIVE CONVERSION TO RAPA AND MYCOPHENOLATE MOFETIL …
- UP-02.50: A study of the role of insulin like growth factor 1 (IGF1) and Rapamycin sensitive signaling in an androgen independent prostate cancer cell line
- … GROWTH FACTOR RECEPTOR (EGFR) INHIBITOR GEFITINIB AND THE MAMMALIAN TARGET OF Rapamycin (mTOR) INHIBITOR EVEROLIMUS
- QUADRUPLE IMMUNOSUPPERSSIVE MAINTENANCE THERAPY USING Rapamycin, LOW-DOSE CYCLOSPORINE, MYCOPHENOLATE MOFETIL, AND …
- PJ-138 New Sesquiterpene Lactone Compared with Rapamycin Inhibits Migration Rather than Proliferation in Rat Vascular Smooth Muscle Cells
- Combination therapy targeting the EWS/FLI-1 oncogene with antisense oligonucleotides and Rapamycin induces apoptosis of Ewing’s sarcoma cells in vitro and …
- … 3-kinase; RTK, receptor tyrosine kinase; S6K, ribosomal S6 kinase; TNF-α, tumor necrosis factor α; TOR, target of Rapamycin; TSC, tuberous sclerosis complex …
- LONG-TERM LIMB ALLOGRAFT SURVIVAL USING A SHORT COURSE OF ANTI-CD45RB MONOCLONAL ANTIBODY, LF15-0195 AND Rapamycin IN A MOUSE …
- A role for HO-1 in the renal function impairment in Rapamycin-treated animals submitted to ischemic and reperfusion injury (IRI).
- Bone Morphogenetic Protein 2 (BMP-2) promotes foci formation through the activation of mammalian target of Rapamycin
- GSK-3/Rb12 Pathway as a Novel Target of Rapamycin in Prostate Cancer
- PII‐9: Improved platelet function in renal transplant patients after conversion from azathioprin to Rapamycin
- Drug-eluting stents, 5-sirolimus stents and oral Rapamycin
- Autophagic Cell Death in Leukemia Cells Regulated by Ceramide and Sphingosine-1-Phosphate through Mammalian Target of Rapamycin.
- 4-(N-Methyl-N-nitrosamino)-1 (3-pyridyl)-1-butanone (NNK) Restored the Cap-dependent Protein Translation Blocked by Rapamycin
- The Saccharomyces cerevisiae GATA-factor activators’ response to the 14-3-3 proteins, nutrient limitation, Rapamycin and MSX treatment, and cis-acting …
- 1871: Rapamycin and Ischemia on Experimental Transplant Arteriosclerosis
- 1158-52 Proteomic profiling of restenotic lesions unveils increased expression of structural proteins that are inhibited by intramural delivery of Rapamycin
- … and Activator of Transcription-1 (STAT1)-dependent Gene Transcription by Lipopolysaccharide and InterferonγIs Regulated by Mammalian Target of Rapamycin
- P-205 STUDIES ON FUNGAL SECONDARY METABOLISM USING Rapamycin AS A MOLECULAR PROBE
- Sphingosine-1-phosphate–induced smooth muscle cell migration involves the mammalian target of Rapamycin
- Rapamycin: something old, something new, sometimes borrowed and now renewed
- Rapamycin and mTOR kinase inhibitors
- Rapamycin is a neuroprotective treatment for traumatic brain injury
- Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex
- Rapamycin prevents early steps of the development of diabetic nephropathy in rats
- Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanism
- Targeting mammalian target of Rapamycin (mTOR) for health and diseases
- A role for mammalian target of Rapamycin in regulating T cell activation versus anergy
- A rational mechanism for combination treatment of Huntington’s disease using lithium and Rapamycin
- Antitumor activity of Rapamycin in a Phase I trial for patients with recurrent PTEN-deficient glioblastoma
- Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation
- The Rapamycin-binding domain of the protein kinase mammalian target of Rapamycin is a destabilizing domain
- The mammalian target of Rapamycin signaling pathway: twists and turns in the road to cancer therapy
- The mammalian target of Rapamycin complex 2 controls folding and stability of Akt and protein kinase C
- Rapamycin, a specific inhibitor of the mammalian target of Rapamycin, suppresses lymphangiogenesis and lymphatic metastasis
- Neuroprotection of Rapamycin in lactacystin-induced neurodegeneration via autophagy enhancement
- inhibition of the mammalian target of Rapamycin impedes lymphangiogenesis
- Contrasting Effects of Cyclosporine and Rapamycin in De Novo Generation of Alloantigen‐Specific Regulatory T Cells
- Metformin inhibits mammalian target of Rapamycin–dependent translation initiation in breast cancer cells
- Roles of rapH and rapG in positive regulation of Rapamycin biosynthesis in Streptomyces hygroscopicus
- Temsirolimus, an inhibitor of mammalian target of Rapamycin
- The Mammalian target of Rapamycin pathway regulates nutrient-sensitive glucose uptake in man
- Silencing mammalian target of Rapamycin signaling by small interfering RNA enhances Rapamycin-induced autophagy in malignant glioma cells
- Selective survival of naturally occurring human CD4+ CD25+ Foxp3+ regulatory T cells cultured with Rapamycin
- Mammalian target of Rapamycin is activated in human gastric cancer and serves as a target for therapy in an experimental model
- Rapamycin inhibits differentiation of Th17 cells and promotes generation of FoxP3+ T regulatory cells
- mTOR inhibition by Rapamycin prevents β-cell adaptation to hyperglycemia and exacerbates the metabolic state in type 2 diabetes
- The mammalian target of Rapamycin-signaling pathway in regulating metabolism and growth,
- Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML
- Hypoxia-inducible factor 1α is regulated by the mammalian target of Rapamycin (mTOR) via an mTOR signaling motif
- Rapamycin inhibits the growth and muscle-sparing effects of clenbuterol
- Rapamycin treatment for a child with germline PTEN mutation
- Effect of Rapamycin alone and in combination with sorafenib in an orthotopic model of human hepatocellular carcinoma
- PRAS40 is a target for mammalian target of Rapamycin complex 1 and is required for signaling downstream of this complex
- Use of sirolimus (Rapamycin) to treat refractory Crohn’s disease
- Rapamycin affects early fracture healing in mice
- Mammalian target of Rapamycin inhibition as a therapeutic strategy in the management of urologic malignancies
- The role of hypothalamic mammalian target of Rapamycin complex 1 signaling in diet-induced obesity
- Re-evaluating the roles of proposed modulators of mammalian target of Rapamycin complex 1 (mTORC1) signaling
- Mammalian target of Rapamycin inhibitor dyslipidemia in kidney transplant recipients
- Dose-and schedule-dependent inhibition of the mammalian target of Rapamycin pathway with everolimus: a phase I tumor pharmacodynamic study in patients with …
- Rapamycin inhibits F-actin reorganization and phosphorylation of focal adhesion proteins
- Rapamycin prevents thyroid hormone-induced cardiac hypertrophy
- Mammalian target of Rapamycin (mTOR) orchestrates the defense program of innate immune cells
- Rapamycin modulates the eNOS vs. shear stress relationship
- Rapamycin inhibits trypanosome cell growth by preventing TOR complex 2 formation
- The mammalian target of Rapamycin regulates lipid metabolism in primary cultures of rat hepatocytes
- Gonadal impact of target of Rapamycin inhibitors (sirolimus and everolimus) in male patients: an overview
- Phase I trial of the novel mammalian target of Rapamycin inhibitor deforolimus (AP23573; MK-8669) administered intravenously daily for 5 days every 2 weeks to …
- Randomized trial of three Rapamycin-eluting stents with different coating strategies for the reduction of coronary restenosis
- Toll-like receptor–mediated induction of type I interferon in plasmacytoid dendritic cells requires the Rapamycin-sensitive PI (3) K-mTOR-p70S6K pathway
- The role of mammalian target of Rapamycin inhibitors in the treatment of advanced renal cancer
- Effects of immunosuppressive drugs on purified human B cells: evidence supporting the use of MMF and Rapamycin
- Mammalian target of Rapamycin as a therapeutic target in oncology
- Pilot study of Rapamycin in patients with hormone-refractory prostate cancer
- Regulation of androgen receptor transcriptional activity by Rapamycin in prostate cancer cell proliferation and survival
- Changes in tumor metabolism as readout for Mammalian target of Rapamycin kinase inhibition by Rapamycin in glioblastoma
- Response of a neuronal model of tuberous sclerosis to mammalian target of Rapamycin (mTOR) inhibitors: effects on mTORC1 and Akt signaling lead to improved …
- inhibition of Mammalian target of Rapamycin by Rapamycin causes the regression of carcinogen-induced skin tumor lesions
- Chemoprevention and treatment of experimental Cowden’s disease by mTOR inhibition with Rapamycin
- Antitumor activity of Rapamycin and octreotide as single agents or in combination in neuroendocrine tumors
- In human endothelial cells Rapamycin causes mTORC2 inhibition and impairs cell viability and function
- Mammalian target of Rapamycin and glycogen synthase kinase 3 differentially regulate lipopolysaccharide-induced interleukin-12 production in dendritic cells
- Mammalian target of Rapamycin pathway activity in hepatocellular carcinomas of patients undergoing liver transplantation
- Differential impact of mammalian target of Rapamycin inhibition on CD4+CD25+Foxp3+ regulatory T cells compared with conventional CD4+ T cells
- Rapamycin is efficacious against primary effusion lymphoma (PEL) cell lines in vivo by inhibiting autocrine signaling
- Dissecting the Akt/mammalian target of Rapamycin signaling network: emerging results from the head and neck cancer tissue array initiative
- Rapamycin impairs in vivo proliferation of islet beta-cells
- Total synthesis of Rapamycin
- Regulation of elongation phase of mRNA translation in diabetic nephropathy: amelioration by Rapamycin
- Systemic inhibition of mammalian target of Rapamycin inhibits fear memory reconsolidation
- The Target of Rapamycin pathway antagonizes pha-4/FoxA to control development and aging
- Rapamycin monotherapy in patients with type 1 diabetes modifies CD4+ CD25+ FOXP3+ regulatory T-cells
- Mammalian target of Rapamycin in the human placenta regulates leucine transport and is down‐regulated in restricted fetal growth
- The mTOR inhibitor Rapamycin significantly improves facial angiofibroma lesions in a patient with tuberous sclerosis
- Rapamycin inhibits osteoblast proliferation and differentiation in MC3T3‐E1 cells and primary mouse bone marrow stromal cells
- Antidepressive-like effects of Rapamycin in animal models: Implications for mTOR inhibition as a new target for treatment of affective disorders
- Alterations in mammalian target of Rapamycin signaling pathways after traumatic brain injury
- Regulatory effects of mammalian target of Rapamycin-activated pathways in type I and II interferon signaling
- Preparation of Rapamycin-loaded chitosan/PLA nanoparticles for immunosuppression in corneal transplantation
- Bnip3 mediates the hypoxia-induced inhibition on mammalian target of Rapamycin by interacting with Rheb
- Sirolimus (Rapamycin): from the soil of Easter Island to a bright future
- Susceptibility of human mesenchymal stem cells to tacrolimus, mycophenolic acid, and Rapamycin
- AKT1 amplification regulates cisplatin resistance in human lung cancer cells through the mammalian target of Rapamycin/p70S6K1 pathway
- Rapamycin-conditioned dendritic cells are poor stimulators of allogeneic CD4+ T cells, but enrich for antigen-specific Foxp3+ T regulatory cells and promote organ …
- Rapamycin, not cyclosporine, permits thymic generation and peripheral preservation of CD4+ CD25+ FoxP3+ T cells
- Dietary energy balance modulates signaling through the Akt/mammalian target of Rapamycin pathways in multiple epithelial tissues
- Rapamycin attenuates the severity of established nephritis in lupus-prone NZB/WF1 mice
- Isolation of hyperactive mutants of mammalian target of Rapamycin
- P-Rex1 links mammalian target of Rapamycin signaling to Rac activation and cell migration
- Rapamycin inhibits polyglutamine aggregation independently of autophagy by reducing protein synthesis
- Bevacizumab and Rapamycin induce growth suppression in mouse models of hepatocellular carcinoma
- Phosphoprotein pathway mapping: Akt/mammalian target of Rapamycin activation is negatively associated with childhood rhabdomyosarcoma survival
- Delivery of Rapamycin by PLGA nanoparticles enhances its suppressive activity on dendritic cells
- Rapamycin regulates the phosphorylation of rictor
- Inhibitors of mammalian target of Rapamycin downregulate MYCN protein expression and inhibit neuroblastoma growth in vitro and in vivo
- Distinct signaling mechanisms activate the target of Rapamycin in response to different B‐cell stimuli
- Therapeutic effect of Rapamycin on gallbladder cancer in a transgenic mouse model
- Rapamycin sensitivity of the Schizosaccharomyces pombe tor2 mutant and organization of two highly phosphorylated TOR complexes by specific and common …
- Activated mammalian target of Rapamycin is an adverse prognostic factor in patients with biliary tract adenocarcinoma
- Expression of an activated mammalian target of Rapamycin in adenocarcinoma of the cervix: A potential biomarker and molecular target therapy
- The effect of immunosuppressive drug Rapamycin on regulatory CD4+ CD25+ Foxp3+ T cells in mice
- Impact of Rapamycin on liver regeneration
- Curcumin inhibits Akt/mammalian target of Rapamycin signaling through protein phosphatase-dependent mechanism
- Combination of Rapamycin and IL-2 increases de novo induction of human CD4+ CD25+ FOXP3+ T cells
- Translational control of c-MYC by Rapamycin promotes terminal myeloid differentiation
- Rapamycin inhibits proliferation of estrogen-receptor-positive breast cancer cells
- An activated mTOR/p70S6K signaling pathway in esophageal squamous cell carcinoma cell lines and inhibition of the pathway by Rapamycin and siRNA against …
- Mammalian target of Rapamycin contributes to the acquired apoptotic resistance of human mesothelioma multicellular spheroids
- Evaluation of antileukaemic effects of Rapamycin in patients with imatinib‐resistant chronic myeloid leukaemia
- Antiproliferative effects of Rapamycin as a single agent and in combination with carboplatin and paclitaxel in head and neck cancer cell lines
- Rapamycin promotes vascular smooth muscle cell differentiation through insulin receptor substrate-1/phosphatidylinositol 3-kinase/Akt2 feedback signaling
- Mammalian target of Rapamycin: master regulator of cell growth in the nervous system
- Binding of Rapamycin analogs to calcium channels and FKBP52 contributes to their neuroprotective activities
- Epstein Barr virus, Rapamycin, and host immune responses
- Regression of subependymal giant cell astrocytoma with Rapamycin in tuberous sclerosis complex
- Effect of Rapamycin on wound healing: an experimental study
- Saccharomyces cerevisiae FKBP12 binds Arabidopsis thaliana TOR and its expression in plants leads to Rapamycin susceptibility
- ASCT2 silencing regulates mammalian target-of-Rapamycin growth and survival signaling in human hepatoma cells
- Small molecule enhancers of Rapamycin-induced TOR inhibition promote autophagy, reduce toxicity in Huntington’s disease models and enhance killing of …
- Mammalian target of Rapamycin (mTOR) is involved in the neuronal differentiation of neural progenitors induced by insulin
- Defects in skin γδ T cell function contribute to delayed wound repair in Rapamycin-treated mice
- Effective in vivo targeting of the mammalian target of Rapamycin pathway in malignant peripheral nerve sheath tumors
- Rapamycin, but not cyclosporine or FK506, alters natural killer cell function
- IL-1β-driven ST2L expression promotes maturation resistance in Rapamycin-conditioned dendritic cells
- Mitogen-activated protein kinase upregulates the dendritic translation machinery in long-term potentiation by controlling the mammalian target of Rapamycin pathway
- CXCR6 induces prostate cancer progression by the AKT/mammalian target of Rapamycin signaling pathway
- Combination strategy targeting the hypoxia inducible factor-1α with mammalian target of Rapamycin and histone deacetylase inhibitors
- Pharmacometrics and delivery of novel nanoformulated PEG-b-poly (ε-caprolactone) micelles of Rapamycin
- Calcineurin inhibitors and Rapamycin: cancer protection or promotion?
- A central role for neuronal AMP-activated protein kinase (AMPK) and mammalian target of Rapamycin (mTOR) in high-protein diet–induced weight loss
- … exercise overcomes the age-related insulin resistance of muscle protein metabolism by improving endothelial function and Akt/mammalian target of Rapamycin …
- Endoplasmic reticulum and Golgi localization sequences for mammalian target of Rapamycin
- Mammalian target of Rapamycin (mTOR) inhibition activates phosphatidylinositol 3-kinase/Akt by up-regulating insulin-like growth factor-1 receptor signaling in acute …
- Rapamycin inhibits cell growth by induction of apoptosis on hepatocellular carcinoma cells in vitro
- Identification of a Highly Effective Rapamycin Schedule that Markedly Reduces the Size, Multiplicity, and Phenotypic Progression of Tobacco Carcinogen–Induced …
- Rapamycin prevents the development of nephritis in lupus-prone NZB/WF1 mice
- Targeting human medulloblastoma: oncolytic virotherapy with myxoma virus is enhanced by Rapamycin
- Rapamycin as an inhibitor of osteogenic differentiation in bone marrow-derived mesenchymal stem cells
- Rapamycin attenuates hypoxia-induced pulmonary vascular remodeling and right ventricular hypertrophy in mice
- Intramural Delivery of Rapamycin With αvβ3-Targeted Paramagnetic Nanoparticles Inhibits Stenosis After Balloon Injury
- FK506 binding protein mediates glioma cell growth and sensitivity to Rapamycin treatment by regulating NF-κB signaling pathway
- Cytoplasmic and nuclear distribution of the protein complexes mTORC1 and mTORC2: Rapamycin triggers dephosphorylation and delocalization of the mTORC2 …
- Oncogenic tyrosine kinase NPM/ALK induces activation of the Rapamycin-sensitive mTOR signaling pathway
- Target of Rapamycin (TOR) signaling controls epithelial morphogenesis in the vertebrate intestine
- Antiangiogenic therapy with mammalian target of Rapamycin inhibitor RAD001 (Everolimus) increases radiosensitivity in solid cancer
- Mammalian target of Rapamycin and S6 kinase 1 positively regulate 6-thioguanine-induced autophagy
- Preparation and characterization of Rapamycin-loaded PLGA coating stent
- Longitudinal inhibition of PI3K/Akt/mTOR signaling by LY294002 and Rapamycin induces growth arrest of adult T-cell leukemia cells
- Suppression of Peutz-Jeghers polyposis by targeting mammalian target of Rapamycin signaling
- Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of Rapamycin inhibitor with potent in …
- Rapamycin retards growth and causes marked alterations in the growth plate of young rats
- … fragile X mental retardation protein (FMRP) with the neuronal protein synthesis-dependent mammalian target of Rapamycin (mTOR) signaling cascade
- Autophagy activation by Rapamycin eliminates mouse Mallory‐Denk bodies and blocks their proteasome inhibitor‐mediated formation
- Mammalian target of Rapamycin inhibitors as possible adjuvant therapy for microscopic residual disease in head and neck squamous cell cancer
- Defective TGF-β signaling sensitizes human cancer cells to Rapamycin
- A retroinhibition approach reveals a tumor cell–autonomous response to Rapamycin in head and neck cancer
- Effects of Rapamycin on gene expression, morphology, and electrophysiological properties of rat hippocampal neurons
- inhibition of mammalian target of Rapamycin induces phosphatidylinositol 3-kinase-dependent and Mnk-mediated eukaryotic translation initiation factor 4E …
- Dietary energy restriction modulates the activity of AMP-activated protein kinase, Akt, and mammalian target of Rapamycin in mammary carcinomas, mammary gland …
- Targeting Protein Translation in Human Non–Small Cell Lung Cancer via Combined MEK and Mammalian Target of Rapamycin Suppression
- Activation of mammalian target of Rapamycin complex 1 and insulin resistance induced by palmitate in hepatocytes
- … concentrations targets the translational machinery to increase the proliferation of human breast cancer cells: involvement of mammalian target of Rapamycin/eIF4E …
- Enhancing mammalian target of Rapamycin (mTOR)–targeted cancer therapy by preventing mTOR/Raptor inhibition-initiated, mTOR/Rictor-independent Akt activation
- Leucine stimulates mammalian target of Rapamycin signaling in C2C12 myoblasts in part through inhibition of adenosine monophosphate-activated protein kinase
- Rapamycin Inhibits Proliferation of Epstein-Barr Virus–Positive B-cell Lymphomas Through Modulation of Cell-Cycle Protein Expression
- Solution structure of the Legionella pneumophila Mip-Rapamycin complex
- Combined therapeutic effects of vinblastine and Rapamycin on human neuroblastoma growth, apoptosis, and angiogenesis
- Azoospermia in a renal transplant recipient during sirolimus (Rapamycin) treatment
- Differential involvement of IκB kinases α and β in cytokine-and insulin-induced mammalian target of Rapamycin activation determined by Akt
- The role of targeting mammalian target of Rapamycin in lung cancer
- Amelioration of protein misfolding disease by Rapamycin: translation or autophagy?
- Monitoring biological action of Rapamycin in renal transplantation
- Efficacy of Rapamycin in scleroderma: a case study
- Statin therapy, alone or with Rapamycin, does not reverse monocrotaline pulmonary arterial hypertension: the rapamcyin-atorvastatin-simvastatin study
- Target of Rapamycin and LST8 proteins associate with membranes from the endoplasmic reticulum in the unicellular green alga Chlamydomonas reinhardtii
- Regulation of mammalian target of Rapamycin activity in PTEN-inactive prostate cancer cells by IκB kinase α
- … regulates hippocampal neurons by elevation of intracellular calcium and activation of calcium/calmodulin protein kinase II and mammalian target of Rapamycin
- The Akt/mammalian target of Rapamycin signal transduction pathway is activated in high-risk myelodysplastic syndromes and influences cell survival and proliferation
- The mammalian target of Rapamycin pathway as a potential target for cancer chemoprevention
- Rapamycin: brain excitability studied in vitro
- Rapamycin‐mediated G1 arrest involves regulation of the Cdk inhibitor Sic1 in Saccharomyces cerevisiae
- Rapamycin-conditioned, alloantigen-pulsed dendritic cells promote indefinite survival of vascularized skin allografts in association with T regulatory cell expansion
- Adiponectin signals in prostate cancer cells through Akt to activate the mammalian target of Rapamycin pathway
- Acidosis-sensing glutamine pump SNAT2 determines amino acid levels and mammalian target of Rapamycin signalling to protein synthesis in L6 muscle cells
- Phosphorylation of ribosomal p70 S6 kinase and Rapamycin sensitivity in human colorectal cancer
- Mammalian Target of Rapamycin Repression by 3, 3′-Diindolylmethane Inhibits Invasion and Angiogenesis in Platelet-Derived Growth Factor-D–Overexpressing …
- Endothelial Akt signaling is rate-limiting for Rapamycin inhibition of mouse mammary tumor progression
- Aging, stem cells, and mammalian target of Rapamycin: a prospect of pharmacologic rejuvenation of aging stem cells
- The mammalian target of Rapamycin kinase and tumor growth inhibition
- Nonimmunosuppressive effects of mammalian target of Rapamycin inhibitors
- Rapamycin reduces VEGF expression in retinal pigment epithelium (RPE) and inhibits RPE-induced sprouting angiogenesis in vitro
- Interplay of PI3K and cAMP/PKA signaling, and Rapamycin-hypersensitivity in TGFβ1 enhancement of FSH-stimulated steroidogenesis in rat ovarian …
- … human vascular smooth muscle cell proliferation and intimal expansion by phosphatidylinositol 3-kinase–dependent mammalian target of Rapamycin raptor complex 1 …
- mTOR is the Rapamycin-sensitive kinase that confers mechanically-induced phosphorylation of the hydrophobic motif site Thr (389) in p70S6k
- Oncolytic virotherapy synergism with signaling inhibitors: Rapamycin increases myxoma virus tropism for human tumor cells
- Juvenile hormone connects larval nutrition with target of Rapamycin signaling in the mosquito Aedes aegypti
- Rapamycin suppresses TLR4-triggered IL-6 and PGE2 production of colon cancer cells by inhibiting TLR4 expression and NF-κB activation
- Protein phosphatase 2A and Rapamycin regulate the nuclear localization and activity of the transcription factor GLI3
- Effect of Rapamycin therapy on coronary artery physiology early after cardiac transplantation
- Low-dose mTOR inhibition by Rapamycin attenuates progression in anti-thy1-induced chronic glomerulosclerosis of the rat
- Immunosuppression and tumor development in organ transplant recipients: the emerging dualistic role of Rapamycin
- Bevacizumab and Rapamycin inhibit tumor growth in peritoneal model of human ovarian cancer
- Effects of the dual phosphatidylinositol 3-kinase/mammalian target of Rapamycin inhibitor NVP-BEZ235 on the tumor vasculature: implications for clinical imaging
- IL-2– and IL-15–induced activation of the Rapamycin-sensitive mTORC1 pathway in malignant CD4+ T lymphocytes
- Mammalian Target of Rapamycin (mTOR) is Activated in Cutaneous Vascular Malformations in Vivo
- Reduction of CCR5 with low-dose Rapamycin enhances the antiviral activity of vicriviroc against both sensitive and drug-resistant HIV-1
- Evaluation of the mammalian target of Rapamycin pathway and the effect of Rapamycin on target expression and cellular proliferation in osteosarcoma cells from dogs
- Differential effects of Rapamycin in anti-GBM glomerulonephritis
- Rapamycin inhibits PAI-1 expression and reduces interstitial fibrosis and glomerulosclerosis in chronic allograft nephropathy
- Coupling of mammalian target of Rapamycin with phosphoinositide 3-kinase signaling pathway regulates protein phosphatase 2a-and glycogen synthase …
- Mammalian target of Rapamycin and caspase inhibitors in polycystic kidney disease
- Pharmacodynamic-guided modified continuous reassessment method–based, dose-finding study of Rapamycin in adult patients with solid tumors
- Statin-dependent suppression of the Akt/mammalian target of Rapamycin signaling cascade and programmed cell death 4 up-regulation in renal cell carcinoma
- Impact of mammalian target of Rapamycin inhibition on lymphoid homing and tolerogenic function of nanoparticle-labeled dendritic cells following allogeneic …
- Antiproliferative and proapoptotic effects of Rapamycin and celecoxib in malignant melanoma cell lines
- Role of the phosphoinositide 3-kinase-Akt-mammalian target of the Rapamycin signaling pathway in long-term potentiation and trace fear conditioning memory in rat …
- Exploiting the mammalian target of Rapamycin pathway in hematologic malignancies
- Simultaneous hybrid coronary revascularization using totally endoscopic left internal mammary artery bypass grafting and placement of Rapamycin eluting stents in the …
- Degradation of Rapamycin and its ring-opened isomer: role of base catalysis
- Sensitizing HER2-overexpressing cancer cells to luteolin-induced apoptosis through suppressing p21WAF1/CIP1 expression with Rapamycin
- Superoxide anions regulate TORC1 and its ability to bind Fpr1: Rapamycin complex
- The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of Rapamycin complex 1
- Topical Rapamycin inhibits tuberous sclerosis tumor growth in a nude mouse model
- Cardiac restricted overexpression of kinase-dead mammalian target of Rapamycin (mTOR) mutant impairs the mTOR-mediated signaling and cardiac function
- Rapamycin at subimmunosuppressive levels inhibits mesangial cell proliferation and extracellular matrix production
- Mammalian target of Rapamycin (mTOR) pathway signalling in lymphomas
- Bronchial and peripheral murine lung carcinomas induced by T790M-L858R mutant EGFR respond to HKI-272 and Rapamycin combination therapy
- Nucleophosmin mediates mammalian target of Rapamycin–Dependent actin cytoskeleton dynamics and proliferation in neurofibromin-deficient astrocytes
- Effects of Rapamycin on cell proliferation and phosphorylation of mTOR and p70S6K in HepG2 and HepG2 cells overexpressing constitutively active Akt/PKB
- Mammalian target of Rapamycin inhibition halts the progression of proteinuria in a rat model of reduced renal mass
- Fatty acid synthase inhibitors modulate energy balance via mammalian target of Rapamycin complex 1 signaling in the central nervous system
- Rapamycin does not improve insulin sensitivity despite elevated mammalian target of Rapamycin complex 1 activity in muscles of ob/ob mice
- inhibition of apoptosis through localized delivery of Rapamycin-loaded nanoparticles prevented neointimal hyperplasia and reendothelialized injured artery
- Epithelial-to-mesenchymal transition of human proximal tubular epithelial cells: effects of Rapamycin, mycophenolate, cyclosporin, azathioprine, and …
- Regulatory effects of mammalian target of Rapamycin-mediated signals in the generation of arsenic trioxide responses
- Leptin induces macrophage lipid body formation by a phosphatidylinositol 3-kinase-and mammalian target of Rapamycin-dependent mechanism
- Non‐human primate fetal kidney transcriptome analysis indicates mammalian target of Rapamycin (mTOR) is a central nutrient‐responsive pathway
- Compared effect of immunosuppressive drugs cyclosporine A and Rapamycin on cholesterol homeostasis key enzymes CYP27A1 and HMG‐CoA reductase
- On the action of cyclosporine A, Rapamycin and tacrolimus on M. avium including subspecies paratuberculosis
- Regulation of proline-rich Akt substrate of 40 kDa (PRAS40) function by mammalian target of Rapamycin complex 1 (mTORC1)-mediated phosphorylation
- Improved blood compatibility of Rapamycin-eluting stent by incorporating curcumin
- Follicle-stimulating hormone increases tuberin phosphorylation and mammalian target of Rapamycin signaling through an extracellular signal-regulated kinase …
- Monitoring antitumor efficacy of Rapamycin in Kaposi sarcoma
- Phosphatidylinositol 3-kinase-AKT-mammalian target of Rapamycin pathway is essential for neuroendocrine differentiation of prostate cancer
- Rapamycin downregulates the inhibitory receptors ILT2, ILT3, ILT4 on human dendritic cells and yet induces T cell hyporesponsiveness independent of FoxP3 …
- Initial testing (stage 1) of the mTOR inhibitor Rapamycin by the pediatric preclinical testing program
- Insulin‐like growth factor‐1 (IGF‐1) and leucine activate pig myogenic satellite cells through mammalian target of Rapamycin (mTOR) pathway
- Rapamycin impairs β-cell proliferation in vivo
- … acid transporters CAT1 and CAT3 mediate NMDA receptor activation-dependent changes in elaboration of neuronal processes via the mammalian target of Rapamycin …
- Upstream signaling inhibition enhances Rapamycin effect on growth of kidney cancer cells
- Hsf1 activation inhibits Rapamycin resistance and TOR signaling in yeast revealed by combined proteomic and genetic analysis
- Cutting edge: Foxp3-mediated induction of pim 2 allows human T regulatory cells to preferentially expand in Rapamycin
- The YCR079w gene confers a Rapamycin-resistant function and encodes the sixth type 2C protein phosphatase in Saccharomyces cerevisiae
- Combination of Rapamycin and 17-allylamino-17-demethoxygeldanamycin abrogates Akt activation and potentiates mTOR blockade in breast cancer cells
- … Signaling Pathway Induces Resistance to the Apoptotic Activities of SCH66336 (Lonafarnib) through Akt/Mammalian Target of Rapamycin–Mediated Increases in …
- Antiproliferative effect of Rapamycin on human T-cell leukemia cell line Jurkat by cell cycle arrest and telomerase inhibition
- A phase 2 clinical trial of deforolimus (AP23573, MK-8669), a novel mammalian target of Rapamycin inhibitor, in patients with relapsed or refractory hematologic …
- Ocular toxicity and distribution of subconjunctival and intravitreal Rapamycin in horses
- Response of U87 glioma xenografts treated with concurrent Rapamycin and fractionated radiotherapy: possible role for thrombosis
- Mammalian target of Rapamycin activation impairs hepatocytic differentiation and targets genes moderating lipid homeostasis and hepatocellular growth
- Regression of pulmonary lymphangioleiomyomatosis (PLAM)-associated retroperitoneal angiomyolipoma post–lung transplantation with Rapamycin treatment
- Regulation of neurogenesis and epidermal growth factor receptor signaling by the insulin receptor/target of Rapamycin pathway in Drosophila
- inhibition of mammalian target of Rapamycin signaling by 2-(morpholin-1-yl) pyrimido [2, 1-α] isoquinolin-4-one
- Further delineation of the continuous human neoplastic enterochromaffin cell line, KRJ-I, and the inhibitory effects of lanreotide and Rapamycin
- Intracellular mechanisms of metabolism regulation: the role of signaling via the mammalian target of Rapamycin pathway and other routes
- Loss of tuberous sclerosis complex-2 function and activation of mammalian target of Rapamycin signaling in endometrial carcinoma
- The mammalian target of Rapamycin pathway and its role in molecular nutrition regulation
- Cotylenin A, a new differentiation inducer, and Rapamycin cooperatively inhibit growth of cancer cells through induction of cyclin G2
- Effects of Rapamycin in liver transplantation.
- Rapamycin inhibits multiple stages of c-Neu/ErbB2–induced tumor progression in a transgenic mouse model of HER2-positive breast cancer
- Rapamycin enriches for CD4+ CD25+ CD27+ Foxp3+ regulatory T cells in ex vivo-expanded CD25-enriched products from healthy donors and patients with …
- Rapamycin down-regulates LDL-receptor expression independently of SREBP-2
- Differential regulation of vascular endothelial growth factor by Akt and mammalian target of Rapamycin inhibitors in cell lines derived from childhood solid tumors
- Forkhead box protein O1 negatively regulates skeletal myocyte differentiation through degradation of mammalian target of Rapamycin pathway components
- Effects of Rapamycin on active Heymann nephritis
- Rationale for a phase I trial of erlotinib and the mammalian target of Rapamycin inhibitor everolimus (RAD001) for patients with relapsed non–small cell lung cancer
- Regulation of interleukin-6-induced hepatic insulin resistance by mammalian target of Rapamycin through the STAT3-SOCS3 pathway
- Targeting the phosphatidylinositol 3-kinase/Akt/mammalian target of Rapamycin module for acute myelogenous leukemia therapy: from bench to bedside
- Rapamycin reduces CCR5 mRNA levels in macaques: potential applications in HIV-1 prevention and treatment
- … and inducible nitric-oxide synthase expression through the integrin/integrin-linked kinase/Akt/mammalian target of Rapamycin pathway in osteoblasts
- Rapamycin reverses NPM-ALK-induced glucocorticoid resistance in lymphoid tumor cells by inhibiting mTOR signaling pathway, enhancing G 1 cell cycle …
- Rapamycin enhances the number of alloantigen-induced human CD103+ CD8+ regulatory T cells in vitro
- GADD34 inhibits mammalian target of Rapamycin signaling via tuberous sclerosis complex and controls cell survival under bioenergetic stress
- Delivery of Rapamycin‐loaded nanoparticle down regulates ICAM‐1 expression and maintains an immunosuppressive profile in human CD34+ progenitor‐derived …
- Four-year clinical follow-up of the Rapamycin-eluting stent evaluated at Rotterdam Cardiology Hospital registry
- Human melanoma cytolysis by combined inhibition of mammalian target of Rapamycin and vascular endothelial growth factor/vascular endothelial growth factor …
- Surgical wound‐healing complications in heart transplant recipients treated with Rapamycin
- Mammalian target of Rapamycin as a target in hematological malignancies
- Does addition of estradiol improve the efficacy of a Rapamycin-eluting stent? Results of the ISAR-PEACE randomized trial
- The effects of Rapamycin in the progression of renal fibrosis
- Mechanism of apoptosis induced by IFN-α in human myeloma cells: role of Jak1 and Bim and potentiation by Rapamycin
- p21-activated kinase 1 is activated through the mammalian target of Rapamycin/p70 S6 kinase pathway and regulates the replication of hepatitis C virus in …
- Effect of supplemental dietary zinc on the mammalian target of Rapamycin (mTOR) signaling pathway in skeletal muscle and liver from post-absorptive mice
- Combined treatment with triptolide and Rapamycin prolongs graft survival in a mouse model of cardiac transplantation
- Synergistic effect of mTOR inhibitor Rapamycin and fluorouracil in inducing apoptosis and cell senescence in hepatocarcinoma cells
- Rapamycin stimulates arginine influx through CAT2 transporters in human endothelial cells
- Mammalian target of Rapamycin is the key effector of phosphatidylinositol-3-OH–initiated proliferative signals in the thyroid follicular epithelium
- Down-regulation of phosphatidylinositol 3′-kinase/AKT/molecular target of Rapamycin metabolic pathway by primary letrozole-based therapy in human breast cancer
- The combination of novel low molecular weight inhibitors of RAF (LBT613) and target of Rapamycin (RAD001) decreases glioma proliferation and invasion
- EMAP-II downregulation contributes to the beneficial effects of Rapamycin after vascular injury
- Rescue of Degradation‐Prone Mutants of the FK506‐Rapamycin Binding (FRB) Protein with Chemical Ligands
- Antiproliferative and overadditive effects of Rapamycin and FTY720 in pancreatic cancer cells in vitro
- Rapamycin for treatment of refractory dysthyroid compressive optic neuropathy
- Randomized trial of Rapamycin-and paclitaxel-eluting stents with identical biodegradable polymeric coating and design
- Nutrient content of diet affects the signaling activity of the insulin/target of Rapamycin/p70 S6 kinase pathway in the African malaria mosquito Anopheles gambiae
- Rapamycin delays growth of Wnt-1 tumors in spite of suppression of host immunity
- Rapamycin together with herceptin significantly increased anti‐tumor efficacy compared to either alone in ErbB2 over expressing breast cancer cells
- Short-and long-term effects of cytochalasin D, paclitaxel and Rapamycin on wall thickening in experimental porcine vein grafts
- Bile acid exposure up-regulates tuberous sclerosis complex 1/mammalian target of Rapamycin pathway in Barrett’s-associated esophageal adenocarcinoma
- A phase II study of oral mammalian target of Rapamycin (mTOR) inhibitor, RAD001 (everolimus), in patients with recurrent endometrial carcinoma (EC)
- Rapamycin shows anticancer activity in primary chronic lymphocytic leukemia cells in vitro, as single agent and in drug combination
- External application of Rapamycin-eluting film at anastomotic sites inhibits neointimal hyperplasia in a canine model
- Rapamycin blunts nutrient stimulation of eIF4G, but not PKCε phosphorylation, in skeletal muscle
- ABT-263 and Rapamycin act cooperatively to kill lymphoma cells in vitro and in vivo
- mTOR inhibitors (Rapamycin and its derivatives) and nitrogen containing bisphosphonates: bi-functional compounds for the treatment of bone tumours
- DCO2 on-line measurement used in Rapamycin fed-batch fermentation process
- Identification of the Rapamycin‐sensitive phosphorylation sites within the Ser/Thr‐rich domain of the yeast Npr1 protein kinase
- Golgi Manganese Transport Is Required for Rapamycin Signaling in Saccharomyces cerevisiae
- How to control lymphangiogenesis: A novel role for Rapamycin
- Decorin-mediated regulation of fibrillin-1 in the kidney involves the insulin-like growth factor-I receptor and Mammalian target of Rapamycin
- Components of the Vid30c are needed for the Rapamycin-induced degradation of the high-affinity hexose transporter Hxt7p in Saccharomyces cerevisiae
- An approach to analyse the specific impact of Rapamycin on mRNA-ribosome association
- Ex vivo Rapamycin generates apoptosis-resistant donor Th2 cells that persist in vivo and prevent hemopoietic stem cell graft rejection
- Rapamycin-regulated control of antiangiogenic tumor therapy following rAAV-mediated gene transfer
- Rapamycin prevents mesenteric neo‐angiogenesis and reduces splanchnic blood flow in portal hypertensive mice
- Upregulation of tissue factor expression and thrombogenic activity in human aortic smooth muscle cells by irradiation, Rapamycin and paclitaxel
- Chylous ascites in a renal transplant recipient under sirolimus (Rapamycin) treatment
- Combination antifungal therapy involving amphotericin B, Rapamycin and 5-fluorocytosine using PEG-phospholipid micelles
- Serotonin Induces Memory-Like, Rapamycin-Sensitive Hyperexcitability in Sensory Axons of Aplysia That Contributes to Injury Responses
- Activation of the mammalian target of Rapamycin complex 1 is both necessary and sufficient to stimulate eukaryotic initiation factor 2Bɛ mRNA translation and protein …
- Human herpesvirus‐8 (HHV‐8)‐associated primary effusion lymphoma in two renal transplant recipients receiving Rapamycin
- An RNA Interference Screen Identifies a Novel Regulator of Target of Rapamycin That Mediates Hypoxia Suppression of Translation in Drosophila S2 Cells
- Identification of AUF1 as a Rapamycin-responsive binding protein to the 5′-terminal oligopyrimidine element of mRNAs
- Mitogen-stimulated and Rapamycin-sensitive glucose transporter 12 targeting and functional glucose transport in renal epithelial cells
- Targeting 14-3-3 sensitizes native and mutant BCR-ABL to inhibition with U0126, Rapamycin and Bcl-2 inhibitor GX15-070
- Modulation of the activities of AMP‐activated protein kinase, protein kinase B, and mammalian target of Rapamycin by limiting energy availability with 2‐deoxyglucose
- PTEN and Rapamycin inhibiting the growth of K562 cells through regulating mTOR signaling pathway
- Role of adenosine 5′-monophosphate-activated protein kinase subunits in skeletal muscle mammalian target of Rapamycin signaling
- Pharmacokinetics of sirolimus (Rapamycin) in subjects with severe hepatic impairment
- … Preconditioning Decreases Myocardial Infarction in Rabbits via Up-regulation of Hypoxia Inducible Factor 1 That Is Mediated by Mammalian Target of Rapamycin
- Stress and IGF-I differentially control cell fate through mammalian target of Rapamycin (mTOR) and retinoblastoma protein (pRB)
- … of the neuronal monocarboxylate transporter MCT2 by translational activation via stimulation of the phosphoinositide 3‐kinase–Akt–mammalian target of Rapamycin …
- Possible involvement of persistent activity of the mammalian target of Rapamycin pathway in the cisplatin resistance of AFP-producing gastric cancer cells
- Cyclin B synthesis and Rapamycin‐sensitive regulation of protein synthesis during starfish oocyte meiotic divisions
- Comparison of a polymer‐free Rapamycin‐eluting stent (YUKON) with a polymer‐based paclitaxel‐eluting stent (TAXUS) in real‐world coronary artery lesions
- The Rheb switch 2 segment is critical for signaling to target of Rapamycin complex 1
- Cyclosporine A and Rapamycin induce in vitro cholesteryl ester transfer protein activity, and suppress lipoprotein lipase activity in human plasma
- Rapamycin reduces CCR5 density levels on CD4 T cells, and this effect results in potentiation of enfuvirtide (T-20) against R5 strains of human immunodeficiency …
- Three‐year clinical outcomes after coronary stenting of chronic total occlusion using sirolimus‐eluting stents: Insights from the Rapamycin‐eluting stent evaluated at …
- Chronic alcohol consumption alters mammalian target of Rapamycin (mTOR), reduces ribosomal p70s6 kinase and p4E-BP1 levels in mouse cerebral cortex
- Intrinsically lower AKT, mammalian target of Rapamycin, and hypoxia-inducible factor activity correlates with increased sensitivity to 2-deoxy-D-glucose under hypoxia …
- … preclinical studies: timing of treatment, combination of a Rapamycin analog (CCI-779) and interferon-gamma, and comparison of Rapamycin to CCI-779
- Rapamycin limits formation of active eukaryotic initiation factor 4F complex following meal feeding in rat hearts
- CD8+ T‐Cell Depletion and Rapamycin Synergize with Combined Coreceptor/Stimulation Blockade to Induce Robust Limb Allograft Tolerance in Mice
- Antineoplastic effect of Rapamycin is potentiated by inhibition of IRS-1 signaling in prostate cancer cells xenografts
- Mammalian target of Rapamycin pathway inhibition enhances the effects of 5-aza-dC on suppressing cell proliferation in human gastric cancer cell lines
- The Cairo kidney center protocol for Rapamycin-based sequential immunosuppression in kidney transplant recipients: 2-year outcomes
- … of insulin-like growth factor binding protein-2 by MCF-7 breast cancer cells is regulated through the phosphatidylinositol 3-kinase/AKT/mammalian target of Rapamycin …
- Total synthesis studies on macrocyclic pipecolic acid natural products: FK506, the antascomicins and Rapamycin
- IGF-I receptor inhibition combined with Rapamycin or temsirolimus inhibits neuroblastoma cell growth
- Chronic allograft dysfunction: can we use mammalian target of Rapamycin inhibitors to replace calcineurin inhibitors to preserve graft function?
- The mammalian target of Rapamycin complex 1 regulates leptin biosynthesis in adipocytes at the level of translation: the role of the 5′-untranslated region in the …
- Rapamycin enhances the anti-tumor effect of gemcitabine in pancreatic cancer cells.
- Renal cortex neuronal nitric oxide synthase in response to Rapamycin in kidney transplantation
- The MAP kinase-activated protein kinase Rck2p plays a role in Rapamycin sensitivity in Saccharomyces cerevisiae and Candida albicans
- … Factor‐1 and Transforming Growth Factor‐β Controls the Quiescence/Cycling Switch of CD34+ Progenitors Through FoxO3 and Mammalian Target of Rapamycin
- The effect of Rapamycin on DNA synthesis in multiple tissues from late gestation fetal and postnatal rats
- Rapamycin reverses TLR4 signaling-triggered tumor apoptosis resistance by disrupting Akt-mediated Bcl-xL upregulation
- Reversal of tacrolimus‐related hypertrophic cardiomyopathy after conversion to Rapamycin in a pediatric liver transplant recipient
- Mechanisms of mammalian target of Rapamycin inhibition in sarcoma: present and future
- siRNA targeting mammalian target of Rapamycin (mTOR) attenuates experimental proliferative vitreoretinopathy
- Synthesis, characterization and antiproliferative activity of Rapamycin-loaded poly (N-isopropylacrylamide)-based nanogels in vascular smooth muscle cells
- Prolongation of cardiac allograft survival by Rapamycin and the invariant natural killer T cell glycolipid agonist OCH
- Rapamycin Inhibits Growth Factor-Induced Cell Cycle Regulation in Pancreatic β Cells
- Molecular impacts of Rapamycin-based drug combinations: combining Rapamycin with gemcitabine or imatinib mesylate (Gleevec) in a human leiomyosarcoma model
- Rapamycin-induced cytotoxic signal transduction pathway
- Effect of rifampicin to inhibit Rapamycin-induced autophagy via the suppression of protein phosphatase 2A activity
- Specific mTOR inhibitor Rapamycin enhances cytotoxicity induced by alkylating agent 1-(4-amino-2-methyl-5-pyrimidinyl) methyl-3-(2-chloroethyl)-3-nitrosourea …
- Requirements of phosphatidylinositol-3 kinase and mammalian target of Rapamycin for estrogen-induced proliferation in uterine leiomyoma-and myometrium-derived …
- Mass balance in Rapamycin autoxidation
- Targeting the mammalian target of Rapamycin in myxoid chondrosarcoma
- Acetaldehyde promotes Rapamycin-dependent activation of p70S6K and glucose uptake despite inhibition of Akt and mTOR in dopaminergic SH-SY5Y human …
- Conversion to Rapamycin immunosuppression for malignancy after kidney transplantation
- Normal phase and reverse phase HPLC-UV-MS analysis of process impurities for Rapamycin analog ABT-578: Application to active pharmaceutical ingredient process …
- Non-Conventional method for evaluation and optimization of medium components for Rapamycin production by Streptomyces hygroscopicus
- Administration of triiodo-L-thyronine into dorsal hippocampus alters phosphorylation of Akt, mammalian target of Rapamycin, p70S6 kinase and 4E-BP1 in rats
- Possible mechanism by which Rapamycin increases cyclosporine nephrotoxicity
- … Extracellular Signal-regulated Kinase 1/2 and c-Jun NH2-Terminal Kinase Downstream of Phosphatidylinositol 3-Kinase and Mammalian Target of Rapamycin
- Adverse effects of mammalian target of Rapamycin inhibitors during the postoperative period after cardiac transplantation
- ABT-869, a multi-targeted tyrosine kinase inhibitor, in combination with Rapamycin is effective for subcutaneous hepatocellular carcinoma xenograft
- Neointimal expression of Rapamycin receptor FK506-binding protein FKBP12: postinjury animal and human in-stent restenosis tissue characteristics
- Successful treatment of post-renal transplant gastric and pulmonary Kaposi’s sarcoma with conversion to Rapamycin treatment
- A comparison of clinical and angiographic outcomes after Excel bioabsorbable polymer versus Firebird durable polymer Rapamycin-eluting stent for the treatment of …
- Effect of Rapamycin on hepatocyte function and proliferation induced by growth factors
- Lentiviral vectors mediate nonimmunosuppressive Rapamycin analog-induced production of secreted therapeutic factors in the brain: regulation at the level of …
- Rapamycin bypasses vesicle-mediated signaling events to activate Gln3 in Saccharomyces cerevisiae
- Nanoparticle albumin-bound (nab) Rapamycin as an anticancer agent
- Rapamycin conditionally inhibits Hsp90 but not Hsp70 mRNA translation in Drosophila: implications for the mechanisms of Hsp mRNA translation
- Differential modulation of mitogen driven proliferation and homeostasis driven proliferation of T cells by Rapamycin, Ly294002 and chlorophyllin
- A phase 1b study of oral Rapamycin (sirolimus) in patients with advanced malignancies
- Rapamycin-loaded poly (lactic-co-glycolic) acid nanoparticles for intraarterial local drug delivery: preparation, characterization, and in vitro/in vivo release
- A Combination of Donor Specific Transfusion and Rapamycin Prolonges Cardiac Allograft Survival in Mice
- Immunoassay determination of Rapamycin: reliability of the method with respect to liquid chromatography mass spectrometric quantification
- Thrombin induces osteoprotegerin synthesis via phosphatidylinositol 3′‐kinase/mammalian target of Rapamycin pathway in human periodontal ligament cells
- Galectin-1 upregulates glucose transporter-1 expression level via protein kinase C, phosphoinositol-3 kinase, and mammalian target of Rapamycin pathways in mouse …
- inhibition of the mammalian target of Rapamycin (mTOR) in a case of refractory primary cutaneous anaplastic large cell lymphoma
- Magic with Rapamycin
- Rapamycin promotes emergence of IL-10-secreting donor lymphocyte infusion-derived T cells without compromising their graft-versus-leukemia reactivity
- Rapamycin and cyclosporine have different effects on expression of Ang-1 and Ang-2 and Tie2 in rat renal allograft with chronic allograft nephropathy
- Phorbol 12-myristate 13-acetate and serum synergize to promote Rapamycin-insensitive cell proliferation via protein kinase C-eta
- A recent application of fluoro-18-deoxyglucose positron emission tomography, treatment monitoring with a mammalian target of Rapamycin inhibitor: an example …
- Orally administered Rapamycin, dacarbazine or both for treatment of human melanoma evaluated in severe combined immunodeficiency mice
- … /p70S6K signaling pathway constitutively activated in esophageal squamous cell carcinona cell lines and inhibition of the pathway by Rapamycin and siRNA against …
- Anti-CD25 mAb, anti-IL2 mAb, and IL2 block tolerance induction through anti-CD154 mAb and Rapamycin in xenogeneic islet transplantation
- Effect of chemotherapy with cisplatin and Rapamycin against Hep-2 cells in vitro
- A new trick for an old drug: mTOR inhibitor Rapamycin augments the effect of fluorouracil on hepatocellular carcinoma by inducing cell senescence
- Loss of phosphatase and tensin homologue deleted on chromosome 10 and phosphorylation of mammalian target of Rapamycin are associated with progesterone …
- … MCF-7 breast cancer tumors are associated with hyperactivation of the mTOR pathway: therapeutic implications for combination therapy with Rapamycin
- Rapamycin, Mycophenolate Mofetil, Methylprednisolone, and Cytotoxic T-Lymphocyte–Associated Antigen 4 Immunoglobulin–Based Conditioning Regimen to Induce …
- Long-term effects of Rapamycin treatment on insulin mediated phosphorylation of Akt/PKB and glycogen synthase activity
- A fast and simple method to prepare the FKBP-Rapamycin binding domain of human target of Rapamycin for NMR binding assays
- Dentritic cell derived IL-18 production is inhibited by Rapamycin and sanglifehrin A, but not cyclosporine A
- Hypoxia-induced hypomyelination in the developing brain is mammalian target of Rapamycin-4E-binding protein-1 signaling dependent
- Combination of Nab-Rapamycin and Perifosine Induces Synergistic Cytotoxicity and Antitumor Activity Via Autophagy and Apoptosis in Multiple Myeloma (MM)
- Effects of mTOR inhibitor Rapamycin on Smad 3 protein and collagen type I expression in rat myocardial fibroblasts infected with coxsackie virus B 3
- Synergistic effect of Rapamycin (RPM) and PD98059 on cell cycle and mTOR signal transduction in human colorectal cancer cells
- A phase II study of mammalian target of Rapamycin (mTOR) inhibitor RAD001 plus imatinib mesylate (IM) in patients with previously treated advanced renal carcinoma …
- Influence of Rapamycin on rat macrophage viability and chemotaxis toward allogenic pancreatic islet supernates
- Orally administered Rapamycin does not modify rat aortic vascular tone
- Rapamycin inhibits the growth of cholangiocarcinoma cells in vitro
- Sirolimus (Rapamycin) induced proteinuria in a patient undergoing allogeneic hematopoietic stem cell transplant
- Induction effect of Rapamycin combined paclitaxel on apoptosis of ovarian cancer cell lines A2780 and SKOV3 and the molecular mechanism
- Temozolomide combined with the PI3K inhibitor LY294002 or the mTOR inhibitor Rapamycin inhibits melanoma cell growth, survival and invasion
- Negative inotropic effect of Rapamycin on isolated human cardiomyocytes
- PDE4B Activity Controls Glucorticoid and Rapamycin Effects in DLBCL.
- Effects of Rapamycin on intracellular cholesterol homeostasis of glomerular mesangial cell in the presence of interleukin-1β
- TOR (target of Rapamycin) as an anti-cancer target
- The expression of mammalian target of Rapamycin in Ishikawa and HEC-1A cells
- Cancer and transplantation intersect at the mammalian target of Rapamycin
- Expression of connective tissue growth factor in renal interstitial fibrosis after ureteral obstruction and effects of Rapamycin thereupon: experiment with rats
- Rapamycin induces Balb/c murine CD4^+ CD25^+ foxp3^+ T cells proliferations
- Mannan and peptidoglycan induce COX‐2 protein in human PMN via the mammalian target of Rapamycin
- Establishment of a Conjugation System for the Rapamycin Producer Streptomyces hygroscopicus NRRL5491 [J]
- Effeet of Rapamycin on mTOR and eIF-4E expression in coxsackievirus B3-induced rat myocardial cells [J]
- Effects of Rapamycin on human hepatocellular carcinoma xenografts in nude mice [J]
- Induction of PPAR gamma signaling and autophagy as a mechanism mediating acquired Rapamycin resistance in breast cancer models
- A drug interaction study of sorafenib (S) and Rapamycin (R) in patients with advanced malignancies
- Regression of Pulmonary Lymphangioleiomyomatosis (PLAM)-Associated Retroperitoneal Angiomyolipoma Post–Lung Transplantation With Rapamycin Treatment
- Initial use of Rapamycin after kidney transplantation
- Combination of CP-751871, a human monoclonal antibody against the IGF-1 receptor, with Rapamycin results in a highly effective therapy for xenografts derived from …
- Rapamycin controls multiple signalling pathways involved in cancer cell survival
- Phosphatidylinositol 3-kinase/mammalian target of Rapamycin pathway is critical for survival and proliferation of pancreatic cancer stem-like side population cells
- Long-term limb allograft survival using a short course of anti-CD45RB monoclonal antibody, LF 15-0195, and Rapamycin in a mouse model
- Resveratrol-and Rapamycin-induced Morphological Changes to Human Epithelial Colon Cancer DLD-1 Cells
- Phosphoinositide 3-kinase (PI3K) and nutrient sensing mTOR (mammalian target of Rapamycin) pathways control T lymphocyte trafficking
- Does the use of paclitaxel or Rapamycin-eluting stent decrease further need for coronary-artery bypass grafting when compared with bare-metal stent?
- Preclinical rationale for combination targeted therapy in advanced clear cell renal cell carcinoma (RCC): Abrogation of Rapamycin-mediated induction of AKT …
- Effect of Rapamycin on CD4 (+) CD25 (+) regulatory T cells in allo-transplantation tolerance model
- Effects of constant magnetic fields on proliferation and migration of endothelial progenitor cells under Rapamycin intervention: experiment with rats
- Effect of Rapamycin on expression of origin recognition complex 1 mRNA in vascular smooth muscle cells [J]
- The different effects of cyclosporin A and Rapamycin on regulatory CD4+CD25+ T cells: potential relationship with transplant tolerance induction
- Experimental study of stent-based delivery of Rapamycin and tirofiban on preventing in-stent thrombosis and restenosis [J]
- The clinical contrast investigation of Rapamycin eluting stent between domestic-made and imported [J]
- Perivascular delivery of Rapamycin in pluronic gel inhibits neointimal hyperplasia in a rat carotid artery injury model, and the complementary role of carotid …
- Effect of Rapamycin on the cell cycle arrest of T lymphocytes
- mTOR kinase inhibitors exhibit properties that distinguish them from Rapamycin
- … insulin-like growth factor-1 receptor (IGF-1R), enhances the anti-tumor activities of Tarceva in non-small cell lung carcinoma (NSCLC) and Rapamycin in sarcoma cell …
- Conversion to Rapamycin in a renal transplant patient with von Hippel-Lindau disease: encouraging results—a case report
- Rapamycin to the rescue!
- Changes in FDG-PET in response to Rapamycin (R) correlated with Akt pathway inhibition and not with clinical outcome
- Rapamycin inhibits proliferation of cells from TSC skin tumors.
- Expression of mammalian target of Rapamycin and p70 S6 kinase in rabbit periodontal tissues remodeling during orthodontic tooth movement
- Glucose transporter 12 and mammalian target of Rapamycin complex 1 signaling: a new target for diabetes-induced renal injury?
- Clinical Application of Mammalian Target of Rapamycin Inhibitor in Kidney Transplantation
- SYNERGISTIC EFFECT OF CYCLOSPORINE IN Rapamycin-INDUCE DIABETIC DISEASE: 1937
- In Vitro Release of Rapamycin Sustained Eluting Stent Detected by a New Designed Circulating Device
- Cause analysis and treatment of Rapamycin-eluting stent thrombosis [J]
- Elevated phosphorylated mammalian target of Rapamycin (p-mTOR) expression in human neoplasms
- Comparison between the Inhibitory and Cytotoxic Effects of Rapamycin and Paclitaxel on Endothelial Cell Proliferation
- Treatment with sodium butyrate and Rapamycin inhibit growth of human cervical cancer cells
- Pediatric Preclinical Testing Program (PPTP) evaluation of the mTOR inhibitor Rapamycin
- The application of Rapamycin drug-eluting stents in elderly patients with acute myocardial infarction [J]
- Effect of mammalian target of Rapamycin inhibitors on neuroblastoma MYCN expression and tumor growth
- Efficacy and Safety Study of Rapamycin in Treating Mesangial Proliferative Glomerulonephritis: Analysis of 11 Cases
- Effect of Orthodontics on Mammalian Target of Rapamycin and p70 S6 Kinase in Rabbit Periodontal Tissues [J]
- Rapamycin affects eIF-4E expression in rat myocardial fibroblasts infected by Coxsackievirus B3
- Local applied Rapamycin inhibits intimal hyperplasia in vein graft after CABG
- Human monoclonal antibody CP751871, combined with Rapamycin is effective treatment for childhood sarcoma xenografts
- P1-084: Mammalian target of Rapamycin (mTOR) inhibition by RAD001 in patients (pts) with reccurent non-small cell lung cancer (NSCLC): Use of 18F …
- The application of Rapamycin drug-eluting stents in elderly patients with coronary heart disease [J]
- Progress of Rapamycin in hepatocellular carcinoma
- Predicting Rapamycin response using pathway profile in a population of genetically engineered hHer2 driven breast tumor model
- Effect of conversion from calcineurin inhibitors to Rapamycin on chronic allograft nephropathy
- The mTOR inhibitor Rapamycin demonstrates activity against AML in combination with imatinib mesylate and with 5-azacytidine.
- Effeet of Rapamycin on mTOR and eIF-4E expression in coxsackievirus B3-induced rat myocardial cells
- Combined regimen of Rapamycin and ciclosporin in long-term follow-up in renal allograft recipients
- Rapamycin modulates the maturation of rat bone marrow-derived dendritic cells
- Experimental study on Rapamycin-batroxobin eluting stent and its prevention of coronary restenosis after angiophaty [J]
- Cellular differentiation of Rapamycin, PI3 kinase and TOR kinase inhibitors
- Histone deacetylase inhibition with LBH589 inhibits the Rapamycin insensitive Rictor-mTOR (mTORC2) complex and translation initiation factor eIF4E activation in …
- 9B-6 inhibition of Smooth Muscle Proliferation by Ultrasound-Triggered Release of Rapamycin from Microbubbles
- Combination of the VEGF receptor tyrosine kinase sunitinib and the mTOR inhibitor Rapamycin leads to tumor regression in the RENCA model
- Toxicology and safety pharmacology of nanoparticle albumin-bound (nab) Rapamycin (ABI-009)
- Rapamycin potentiates the effects of paclitaxel in endometrial cancer cells through inhibition of cell proliferation and induction of apoptosis.
- Expression and secretion of VEGF in solid tumor cells is mediated by the mammalian target of Rapamycin (mTOR)
- The design and pharmacokinetics in vivo of Rapamycin-PLGA membrane eluting stent [J]
- Rapamycin combined with donor bone marrow-derived immature dendritic cells induces mouse skin allograft tolerance
- Anti-Proliferative Effect of Rapamycin on Human T Cell Leukemia Cell Line Jurkat by Cell Cycle Arrest and Telomerase inhibition.
- Phase I study of gefitinib and Rapamycin in adult patients with recurrent glioblastoma multiforme (GBM)
- Rapamycin-induced inhibition of HTLV-I LTR activity is rescued by c-Myb
- Effect of RNA interference targeting mammalian target of Rapamycin on the proliferation of vascular smooth muscle cell and the intimal hyperplasia
- Anti-Cancer Effects of Rapamycin on U937 Cell Line.
- Comparison of inflammatory markers and angiographic outcomes after implantation of Rapamycin and paclitaxel-eluting stents
- The roles of mammalian target of Rapamycin (mTOR) and p21 in the autophagy pathway after DNA mismatch repair processing of 6-thioguanine
- Molecular determinants of sensitivity to Rapamycin in NSCLC
- Dasatinib and Rapamycin synergistically inhibit the proliferation of cells expressing oncogenic KIT kinase via global inhibition of AKT-dependent signaling
- Anti-angiogenic activity of Rapamycin in Rapamycin-sensitive and-resistant tumor xenograft models
- Mammalian target of Rapamycin impairs insulin’s ability to promote protein kinase B phosphorylation in isolated rat skeletal muscle
- Dual Effects of Rapamycin on Immuno-suppression and Tumor inhibition
- Rapamycin Inhibits Proliferation of Human Lung Cancer Cell Lines [J]
- Combination therapy with Rapamycin and atorvastatin
- PI-103, a Dual Inhibitor of Class IA Phosphatidylinositol 3-Kinase and Mammalian Target of Rapamycin, Has Cytotoxic Activity in T-Cell Acute Lymphoblastic …
- The effects of Rapamycin on body weight and insulin resistance in KKAy mice
- Cell Proliferation in Multiple Rat Tissues In Vivo is Rapamycin Resistant
- The Effect of Rapamycin on Repair of Liver Ischemia/Reperfusion Injury
- Genetically engineered murine tumor models for drug response prediction: population based pathway profiles predict response to Rapamycin in a HER2 driven breast …
- The effect of Rapamycin on PSA kinetics in men without prostate cancer
- Chronic exposure to Rapamycin induces endothelial dysfunction in vitro
- Antiproliferative effects of mTOR inhibition with Rapamycin (RAP) either given as a single agent or in combination with carboplatin and paclitaxel in Human Head and …
- P158-M Expression of c-kit, p-mTOR and p-NFKappaB in angiolymphoid hyperplasia with eosinophilia: Potential for therapy with imitanib mesylate, Rapamycin and …
- Use of Rapamycin to inhibit VEGF for the treatment of primary effusion lymphoma
- Rapamycin and CCI-779 suppress the growth of hepatocellular carcinoma cells
- Combined effects of Rapamycin and bicalutamide in androgen-dependent and-independent prostate cancer cells
- Cholangiocarcinoma cells are selectively susceptible to Rapamycin treatment
- The Mammalian Target of Rapamycin and Multiple Myeloma
- Rapamycin modulates the eNOS versus shear stress relationship
- Effect of Rapamycin on the Proliferation and Apoptosis of Human Leukemia Cell Line HL-60 [J]
- EFFECTS OF Rapamycin COMBINED IMMUNOSUPPRESSION ON RENAL FUNCTION AFTER LIVER TRANSPLANTATION
- Effects of Rapamycin on proliferation, function and cell-cycle of mouse T lymphocytes in vitro
- Mammalian target of Rapamycin and leukemia treatment
- Clinical utility of combined administration of Rapamycin and low dose of cyciosporin a in kidney transplantation recipients
- Rapamycin Induced Transactivation of EGFR: Implications in the Regulation of Cellular Apoptosis
- The mammalian target of Rapamycin (mTOR). Foreword.
- Mammalian Target of Rapamycin Activation Impairs
- Clinical application of Rapamycin-eluting stent in coronary artery disease
- Differential response of mTORC1 and mTORC2 to Rapamycin in Rapamycin-sensitive and-resistant tumor xenograft models
- Effect of IGF‐I and Rapamycin on diaphragm muscle atrogenes with malnutrition
- Functional genomic identification and validation of Rapamycin response genes using high throughput RNA interference
- Rapamycin increases sensitivity to cisplatin in mesothelioma cell lines
- Rapamycin inhibition of cell motility is associated with its suppression of synthesis of GTPases
- Yeast as a Model to Study the Immunosuppressive and Chemotherapeutic Drug Rapamycin
- MANAGEMENT AND LONG-TERM OUTCOMES OF WOUND-HEALING COMPLICATIONS ASSOCIATED WITH Rapamycin: 1108
- Rapamycin Augments Akt Activation in In Vitro and In Vivo Models of Cardiac Hypertrophy
- The study of anti-proliferation effect of Rapamycin on human breast cancer MCF-7 cells under hypoxia [J]
- Rapamycin Reduces CCR5 Density Levels
- Rapamycin inhibits Stearoyl-CoA Desaturase 1 expression in breast cancer cell lines.
- Overexpression analysis reveals novel growth regulators in the target of Rapamycin signaling pathway
- Nutrient Stimulation of eIF4G Phosphorylation, but not PKC is Rapamycin Sensitive in Skeletal Muscle
- Role of Rapamycin on cultured human Tenon′ s capsule fibroblasts
- Statins and Rapamycin act synergistically to enhance vascular endothelial cytoprotection
- Antitumor activity of Rapamycin and octreotide as single agents or in combination in neuroendocrine tumors
- Acute Rapamycin Treatment Does Not Improve In Vivo Insulin Action in Ob/Ob or High Fat Fed Mice
- Administration of Rapamycin in vivo and in vitro prolonged allograft survival associated with iTregs
- THE EFFECT OF LIVER REGENERATION ON Rapamycin PHARMACOKINETICS: 1226
- The Clinical Application of Rapamycin Eluting Stent in Elderly Patients with Coronary Heart Disease.
- Rapamycin induced “stunning” on FDG PET/CT in pancreatic cancer
- Protective Effect of Pretreated Rapamycin on Renal Ischemia-Reperfusion Injury in Rats
- Rapamycin impairs skin γδ T cell function resulting in autophagy
- Rapamycin aggravates the renal damage in rats with protein overload nephropathy and the protection of losartan
- Observation in Safety and Short-term Efficacy of Domestic-made Rapamycin-eluting Stent
- Rapamycin Treatment Exacerbates Nutrition-Induced Diabetes in Psammomys obesus.
- Rapamycin‐sensitive inhibition of Id1 and p21 in C2C12 myoblasts
- Effects of Rapamycin on the Liver Regeneration after Partial Hepatectomy in Rats
- Statin therapy, alone or in combination with Rapamycin, does not reverse Monocotaline Pulmonary Arterial Hypertension
- Comparative study on clinical outcomes of two kinds of Chinese Rapamycin-eluting stent in patients with coronary artery disease
- Rapamycin rescues lactacystin-induced dopaminergic neuron injury in vivo
- Modulation of cell cycle progression by combined Rapamycin-octreotide treatment in pituitary tumor cells
- Local application of Rapamycin inhibits neointimal hyperplasia in experimental vein grafts
- Histologic Changes After Intravitreal Injection of Rapamycin and Bevacizumab in a Porcine Model
- Bevacizumab and Rapamycin induce growth suppression in mouse models of hepatocellular carcinoma
- Study on the activation of mammalian target of Rapamycin in two endometrial carcinoma cells
- Study on the changes of mammalian target of Rapamycin with aging in rat kidneys
- 290: Rapamycin-generated Th2 cell therapy of established acute murine GVHD requires Th2 cell secretion of both IL-4 and IL-10
- Rapamycin CAN AMELIORATE CAN IN RAT ALLOGRAFTS BY AFFECTING RHO/ROCK SIGNAL PATHWAY: 2147
- Clinical study on major adverse cardiac events (MACE) rate in patients implanted with Rapamycin-eluting stents [J]
- Preclinical evaluation of sorafenib in combination with Rapamycin for the treatment of acute myeloid leukemia (AML)
- The Development and Molecular Expression in Mammalian Cells of an HA-Tagged Plasmid Encoding for the Target Of Rapamycin (mTOR)
- The Role of Mammalian Target of Rapamycin (mTOR) Inhibitors in the Treatment of Solid Tumors
- INFLUENCE OF Rapamycin ON RENAL TUBULAR FUNCTION IN RATS WITH OR WITHOUT CYCLOSPORINE TREATMENT: 1938
- Drug eluting stents: long term results in clinical practice. Comparison between Rapamycin and paclitaxel eluting stents
- Nucleophosmin Mediates Mammalian Target of Rapamycin
- Rapamycin inhibits activation of Stat3 in kidney tissue of IgA nephropathy rats
- Leukemia Induced by Altered TRK-Signaling Is Sensitive to Rapamycin Treatment in a Preclinical Model
- Mechanisms of urokinase mediated activation of the mammalian target of Rapamycin (mTOR)
- UROKINASE‐INDUCED SMOOTH MUSCLE CELL MIGRATION INVOLVES THE MAMMALIAN TARGET OF Rapamycin
- Anti-inflammatory properties of Rapamycin on leukocyte-endothelial cell interactions following profound hypoperfusion
- Contrasting effects of Cyclosporine and Rapamycin in de novo generation of alloantigen-specific regulatory T cells (88.45)
- Combination treatment of Rapamycin and low dose irradiation causes cell death in human cancer cells cultured as 3-D spheroids
- Rapamycin effects on mTOR signaling in the MCF10AT series of human breast epithelial cells: a model for proliferative breast disease and carcinoma
- Anti-inflammatory drugs, sirolimus, and inhibition of target of Rapamycin and its effect on vascular diseases
- Effect of Rapamycin in inducing naïve murine effector T cell convert to regulatory T cell
- A high throughput assay for mammalian target of Rapamycin (mTOR) kinase activity
- Rapamycin INDUCES AUTOPHAGY IN ISLETS: RELEVANCE FOR ISLETS TRANSPLANTATION: 556
- Angioplasty stenting with Sirolimus (Rapamycin) eluting stents in type 2 diabetic patients
- The Immunosuppressive drugs Rapamycin and FK506 decrease vasodilation by increasing PKCbetai‐mediated phosphorylation of eNOS Thr495
- Rapamycin inhibition of the Akt/mTOR pathway blocks select stages of VEGF-A driven angiogenesis in part through the blockade of S6Kinase
- Combined Rapamycin-octreotide treatment exerts its superior antiproliferative action by dramatically increasing p27/Kip1 expression
- Characterisation of a novel and highly selective kinase inhibitor of the mammalian target of Rapamycin (mTOR)
- ST2L upregulation promotes maturation resistance in Rapamycin‐conditioned dendritic cells
- P286: Mechanisms of urokinase mediated activation of the mammalian target of Rapamycin (mTOR)
- Akt phosphorylates and negatively regulates hnRNPA1-mediated control of cyclin D1 and c-myc translation in response to Rapamycin
- Intravitreal Rapamycin and Bevacizumab Inhibits VEGF Expression in a Swine Model of Neovascularization
- Acute activation of the mammalian target of Rapamycin complex 1 does not impair in vivo insulin action in mice
- Combined Therapeutic Effects of Vinblastine and Rapamycin on Human Neuroblastoma Growth, Apoptosis, and Angiogenesis
- Cell cycle proteins and hTERT telomerase mRNA expression are independent targets of Rapamycin in ovarian cancer cell lines
- Re-evaluating the roles of proposed modulators of mammalian target of Rapamycin complex 1 (mTORC1) signaling
- P39. Rapamycin and the downstream target of mTOR, ribosomal protein L29 (RPL29), regulate prostate cancer cell growth and bone metastatic potential
- Thymidine phosphorylase-related migratory effect of cancer cell is abrogated by m-TOR inhibitor Rapamycin
- Curcumin inhibition of the mammalian target of Rapamycin signaling pathway
- Synergistic combinations of a novel PI3 Kinase inhibitor with Erlotinib and Rapamycin and the associated effects on downstream signalling
- Evaluation of the mTOT inhibitor, Rapamycin in dogs with spontaneously derived osteosarcoma: A focus on preclinical pharmacokinetics and pharmacodynamics
- Activation of Mammalian Target of Rapamycin (mTOR) in Esophageal Squamous Cell Carcinona Cell Line [J]
- The mammalian target of Rapamycin (mTOR) signaling in thymic lymphomagenesis in Atm-/-mice
- Rapamycin-induced remission of Kaposi’s sarcoma is not associated with expansion of cytotoxic T-lymphocyte subsets
- The Mammalian Target of Rapamycin Plays a Critical Role in the Development of Cardiac Hypertrophy in Spontaneously Hypertensive Rats
- Inhibitory effect of Rapamycin and dexamethasone on production of IL-17 and IFN-c in Vogt–Koyanagi–Harada patients
- Targeted therapy for osteosarcoma using 17AAG and Rapamycin: Identification of new targets by gene microarray profiling and miRNA
- Divergent Roles of PI3K and Akt in Rapamycin-induced Cardioprotection against Ischemia-Reperfusion Injury
- The Combination of the mTOR Inhibitor Rapamycin and Protein Kinase C Inhibitors Produces Marked Synergistic Anti-Myeloma Effects.
- Expansion of Functional Polyclonal Human T-regulatory Cell Lines Using Artificial Antigen Presenting Cells and Rapamycin.(B159)
- Sepsis associated platelet dysfunction & Rapamycin sensitive pathway of lipopolysaccharide signaling
- COMPARISON OF Rapamycin VS. FK506 ON EXPRESSION OF CYTOPROTECTIVE GENES IN THE RAT-KIDNEY ALLOGRAFTS UNDERGOING CHRONIC …
- Synergistic effect of Rapamycin and Casodex in inhibition of cell growth and survival as well as AR transcriptional activity in androgen dependent and independent …
- Clenbuterol antagonizes Rapamycin-induced atrophy in rat soleus muscle
- Ocular Toxicity and Distribution of Intravitreal and Subconjunctival Rapamycin in Horses
- Rapamycin Withdrawal versus Delayed Initiation: Thrombosis vs. Suppression of Neointimal Hyperplasia after Vascular Injury
- Rapamycin prevents cadmium-induced neuronal apoptosis by suppression of MAPK and mTOR pathways
- Changes in gene expression profile after Rapamycin treatment of ErbB2-positive/ErbB2-negative breast carcinoma in organ culture
- Dual inhibition of the Akt pathway by Rapamycin and Perifosine induces synergistic anti-tumor activity in multiple myeloma
- Clinical Benefits of Rapamycin-Eluting Stent Made in China Appliance and Investigation in Patients with Acute Coronary Syndromes
- Rapamycin Causes Reversible Cell Cycle Slowing, Rather Than Cell Cycle Arrest, in Myeloid and Lymphoid Cell Lines and in Acute Leukemia Cells
- Effective inhibition of tumor growth in patient-derived xenografts of hepatocellular carcinoma by Rapamycin and bevacizumab
- Protein kinase C (μ, θ, ϵ)-dependent Bad phosphorylation is an important signaling pathway in IGF-I rescue of sarcoma cells from Rapamycin-induced apoptosis
- Enzastaurin inhibits growth of head and neck cancer cells and xenografts and synergizes with Rapamycin
- Binding of novel Rapamycin analogs to calcium channels and FKBP52 contributes to their neuroprotective activities
- Combination of somatostatin analogues with Rapamycin analogues as a potential pharmaceutical treatment for non-functioning pituitary adenomas
- Mammalian Target of Rapamycin (mTOR) is Essential for Murine Heart Development
- A spontaneous pancreatic tumor model for monitoring pancreatic lesion and response to Rapamycin treatment through bioluminescence imaging
- Targeted therapy for osteosarcoma using 17AAG and Rapamycin: Identification of new targets using Gene Microarray profiling and MiRNA
- Rapamycin regulates synthesis of transforming growth factor-beta1 and extracellular matrix in arterial neointimal smooth muscle cells
- Utilization of Meso Scale Discovery ELISA technology to quantitate the in vivo pharmacodynamic effects of Rapamycin treatment on the AKT pathway
- Rapamycin blocks leucine‐induced protein synthesis by suppressing mTORC1 activation in skeletal muscle of neonatal pigs
- Rapamycin IS LESS FIBROGENIC THAN FK506 IN RAT MODEL OF CHRONIC ALLOGRAFT NEPHROPATHY: 2144
- Identification and characterization of novel positive regulators of the Target of Rapamycin (TOR) pathway in Drosophila melanogaster
- The Role of Mammalian Target of Rapamycin in the Regulation of Amino Acid Transporters in the Human Placenta
- Rapamycin, mTOR inhibitor, a potent inhibitor for the cell growth and proliferation by p21-dependent mitotic arrest in human gastric cancers
- Role of mechanistic Target of Rapamycin (mTOR) signaling in the crustacean molting gland
- … Scale Expansion of Human Dendritic Cells with Regulatory Function from Peripheral Blood Monocytes Employing Leukapheresis and Rapamycin for Clinical Trials.
- Angioplasty stenting with Sirolimus (Rapamycin) eluting stents in type 2 diabetic patients Angioplastia con stents liberadores de rapamicina en diabéticos tipo 2 …
- Rapamycin prevents tobacco-carcinogen induced lung tumorigenesis and selectively reduces lung-associated Foxp3 positive cells
- Clinical observation of Rapamycin Eluting Stent in acute ST-segment elevated myocardial infarction between domestic and imported product
- Targeted therapy for osteosarcoma using 17AAG and Rapamycin: identification of new targets using l Gene microarray profiling and proteomics
- EARLY IMMUNOSUPPRESSION WEANING AFTER CADAVER LIVER TRANSPLANTATION USING ATG INDUCTION AND Rapamycin: 358
- inhibition effect of Rapamycin on acute graft-versus-host disease after allogeneic bone marrow transplantation in a murine model
- Dual inhibition of phosphoinositide 3-kinase and mammalian target of Rapamycin as a novel therapeutic approach in human ovarian carcinoma
- A small molecule inhibitor against kinase domain of mammalian target of Rapamycin (mTOR) causes autophagic cell death in glioblastoma
- Effects of Imatinib and Rapamycin on the mTOR/S6 Signal Transduction Pathway in CD33+ Cell of CML
- mTOR inhibitors Rapamycin and RAD001 (Everolimus) induce antiproliferative effects in GH3 cell line and human pituitary adenomas
- PNEUMONITIS FROM INHIBITORS OF THE MAMMALIAN TARGET OF Rapamycin (mTOR) IN PATIENTS WITH METASTATIC CANCER
- Targeted therapy for osteosarcoma using 17AAG and Rapamycin: Characterization of induced apoptosis and inhibition of mTOR and AKT/MAP kinase pathways
- Blockage of mTOR signaling pathway by Rapamycin contributes to inhibition of tumor cell proliferation in ALK-positive lymphoid cell strains
- The Yaa locus Confers Apoptosis, NF-κB and Rapamycin Signaling Resistance Through Multiple Receptors in C57BL/6J Mice (129.12)
- Domestic versus foreign Rapamycin-eluting stents for emergency percutaneous coronary intervention in elder patients with acute myocardial infarction: Randomized …
- Tumor suppressor gene ARHI (DIRAS3) is required for spontaneous and Rapamycin-induced autophagy in normal and ovarian cancer cells
- Complete Responses in Patients with Autoimmune Lymphoproliferative Syndrome (ALPS) Using the mTOR Inhibitor Sirolimus (Rapamycin)
- Signaling Downstream of Mammalian Target of Rapamycin Complex 1 (mTORC1) is Derepressed Following Treatment with L‐Asparaginase in the Liver of GCN2 …
- MESENCHYMAL STEM CELLS ATTENUATE ACUTE REJECTION AND SYNERGIZE WITH Rapamycin LEADING TO CARDIAC ALLOGRAFT TOLERANCE: 382
- inhibition of the mammalian target of Rapamycin (mTOR) for the chemoprevention of tobacco-carcinogen induced lung tumorigenesis
- mTORC1 inhibition with Rapamycin or LY294002 alone but not in combination leads to AKT phosphorylation via mTORC2 in melanoma cells
- Corrigendum to “Low-dose oral Rapamycin treatment reduces fibrogenesis, improves liver function, and prolongs survival in rats with established liver cirrhosis”[J …
- FK506 VERSUS Rapamycin HAVE DIFFERENT EFFECTS ON EXPRESSION OF ANGIOPOIETINS1, 2 AND TIE2 IN RAT RENAL ALLOGRAFT WITH CAN: 1925
- Combination Therapy Utilizing Murine Anti-Thymocyte Globulin (ATG) and Rapamycin for the Reversal of Overt Type 1 Diabetes in NOD Mice.
- Rapamycin REDUCES VASCULAR INJURY BUT EXACERBATES PROTEINURIA IN ASSOCIATION WITH inhibition OF VEGF AND VEGF-R IN CHRONIC …
- … Inhibitor Causes Growth inhibition, Cell Cycle Arrest, Apoptosis and Autophagic Cell Death in Mantle Cell Lymphoma Cell Lines: A Distinct Profile from Rapamycin.
- Rapamycin PREFERENTIALLY BLOCKS THE EXPANSION OF POTENTIALLY TOLEROGENIC PLASMACYTOID DENDRITIC CELLS IN VIVO: 2217
- Rapamycin DECREASES CHOLESTEROL EFFLUX AND ABCA1 PROTEIN EXPRESSION WITHIN THP-1 MACROPHAGES: 1931
- TARGETED DELIVERY OF Rapamycin TO DENDRITIC CELLS USING BIODEGRADABLE MICROPARTICLES IS HIGHLY EFFECTIVE IN SUPPRESSING THEIR …
- Mating Stimulates Protein Phosphorylation and Synthesis Via Rapamycin-and Wortmannin-Sensitive Pathways in the Male Accessory Glands of D. melanogaster
- Dietary induced insulin resistance is independent of mammalian target of Rapamycin complex 1 (mTORC1) activity in skeletal muscle of mice
- 191: Rapamycin inhibits endothelial cell recovery after hypoxic injury
- Enhancement of Mammalian Target of Rapamycin Complex-2 (TORC2) Kinase Activity by Fructose-2, 6-Bisphosphate.
- Effect of Rapamycin/Curcumin Co-Loaded Poly (Lactide-Co-Glycolide) Films on Blood Compatibility and Vascular Smooth Muscle Cell Proliferation
- COMBINE TGF-BETA/FC AND Rapamycin FOR REGULATORY T CELLS GENERATION AND ALLOGRAFT TOLERANCE INDUCTION.: 728
- The Wnt Agonist, SKL2020 Inhibits Neointimal Hyperplasia but Facilitates Re-Endothelialization, When Treated with Rapamycin in Porcine Coronary Artery Stent …
- IL-1β-DRIVEN ST2 EXPRESSION PROMOTES MATURATION RESISTANCE IN Rapamycin-CONDITIONED DENDRITIC CELLS: 643
- PRO-TOLEROGENIC PROPERTIES OF Rapamycin THAT FAVOR INDEFINITE HEART ALLOGRAFT SURVIVAL MEDIATED BY REGULATORY T CELLS.: 27
- Mechanism of luteolin-induced apoptosis through suppressing p21 (WAF1/CIP1) expression with Rapamycin in HER2-overexpressing cancer cells
- … ALLOGRAFT SURVIVAL IN UNMANIPULATED HOSTS BY POST-TRANSPLANT INFUSION OF DONOR-SPECIFIC REGULATORY T CELLS AND Rapamycin: 655
- Role of the mammalian Target of Rapamycin (mTOR) Complex 1 signaling in beta‐adrenergic‐stimulated triacylglycerol (TAG) lipolysis and free fatty acid (FFA) …
- A phase I study of the mTOR inhibitor sirolimus (Rapamycin) in combination with nanoparticle albumin-bound paclitaxel (ABI-007, abraxane) in advanced solid cancers
- IMPACT OF IMMUNOSUPPRESSION ON UV-INDUCED SKIN-TUMORS IN MICE: Rapamycin IMPAIRS TUMOR OUTGROWTH AND SHIFTS THE MUTATION …
- Dexamethasone represses signaling through mammalian target of Rapamycin (mTOR) in muscle cells by enhancing expression of REDD1
- inhibition of mammalian target of Rapamycin (mTOR) induces phosphatidylinositol 3 kinase-dependent and Mnk-mediated eIF4E phosphorylation
- Rapamycin, mTOR Inhibitor, a Potent Cell Growth and Proliferation Inhibitor by p21-Dependent Mitotic Arrest in Human Gastric Cancers
- Rapamycin PROMOTES THE ENRICHMENT OF CD4+ CD25HIFOXP3+ T REGULATORY CELLS FROM NAIVE CD4+ T CELLS OF BABOON THAT SUPPRESS …
- … with drug eluting stents but with significant cost saving: long term follow up results from the randomized, controlled ORAR III (Oral Rapamycin in Argentina) Study
- PD2-4 Survival Advantage of Temsirolimus Validates a Role for Mammalian Target of Rapamycin (mTOR) in the Biology of Advanced Renal Cell Carcinoma
- P3-026: A novel Bayesian dose-escalation Phase Ib study design investigating combination of the mammalian target of Rapamycin (mTOR) inhibitor RAD001 with …
- Cell cycle arrest and suppression of the Akt/mammalian target of Rapamycin signaling mediated by yuanhuadine, a daphnane diterpenoid, isolated from Daphne …
- … Smooth Muscle Cell Proliferation and Intimal Expansion by Phosphatidylinositol 3-Kinase–Dependent Mammalian Target of Rapamycin Raptor Complex 1 …
- 155. Tumor Necrosis In Vivo Caused by a Novel Combination of Sorafenib and Rapamycin: Targeting the RAS and Motor Pathways ION Hepatocellular Carcinoma
- 342: Rapamycin Prevents GVHD in Mouse Model through Novel Mechanism: Increase in Regulatory T cells
- … downregulates acetyl-CoA carboxylase alpha and fatty acid synthase by activating AMP-activated protein kinase and suppressing the mammalian target of Rapamycin …
- Glycogen Synthase Kinase-3 (GSK-3) Signaling to Mammalian Target of Rapamycin (mTOR) Regulates DNA Synthesis and Cell Cycle Progression in Rodent and …
- THROMBOSPONDIN-1 (TSP-1) MEDIATES THE ANTI ANGIOGENIC AND IMMUNOMODULATORY EFFECTS OF Rapamycin ON PANCREATIC ISLET …
- 53: Rapamycin Partially Overcomes the in vitro Protective Effect of M2–10B4 Mesenchymal Stromal Cells (MSC) to Murine mCGPR/+ Acute Promyelocytic Leukemic …
- … CXC Chemokine Receptor 4 (CXCR4) by Hypoxia and the Phosphatidylinositol 3‐Kinase (PI‐3‐K)/Mammalian Target of Rapamycin (mTOR) Signaling Pathway
- 234: Rapamycin generated donor Th2/Tc2 cells prevent graft rejection by inhibition of alloreactivity and not by deletion of alloreactive T cells
- FoxP3 Mediated Induction of Pim 2 Allows T Regulatory Cells to Preferentially Expand in Rapamycin
- The Novel Glycolysis Inhibitor, 3-BrOP, Has Broad Activity Against Acute Lymphoblastic Leukemias and Potentiates Methotrexate and Rapamycin.
- … -selective oncolytic adenovirus OBP-405 induces autophagic cell death and enhances the antitumor effect of temozolomide and Rapamycin on glioblastoma cells in …
- … regulatory (CD4+ CD25+ CD127LowFOXP3+) cells to high purity by inhibiting expansion of CD4+ CD25+ CD127HighFOXP3-conventional T cells with Rapamycin
- Late stage efficacy and regulated gene expression profiles by 5-aza-dC, valproic acid, suberoylanilide hydroxamic acid, and Rapamycin in mouse lung tumorigenesis
- 720: inhibition of Proliferation by Rapamycin in RAT Bladder Smooth Muscle Cells
- 307: Initial selection of high affinity CD25+ cells increases the purity of CD4+ CD25+ Foxp3+ T regulatory cells expanded in medium containing Rapamycin
- 518: Medium term renal function of pediatric heart transplant patients on reduced calcineurin inhibitor and Rapamycin
- Automated quantitative analysis of AKT/mTOR pathway in patients treated with nanoparticle albumin-bound paclitaxel (ABI-007, Abraxane) and (sirolimus) Rapamycin
- 51: Rapamycin and its influence on arterial vascular function after short-term incubation
- 336: Relative Contribution of CD127 Negative Selection, Rapamycin, and TGF-β to the Generation of Human Regulatory T Cells that Inhibit Alloreactivity via Dendritic …
- An ATP-competitive mammalian target of Rapamycin inhibitor reveals Rapamycin-resistant functions of mTORC1
- Rapamycin decelerates cellular senescence
- Structure of the human mTOR complex I and its implications for Rapamycin inhibition
- Delayed correlation of mRNA and protein expression in Rapamycin-treated cells and a role for Ggc1 in cellular sensitivity to Rapamycin
- Rapamycin inhibits mTORC1, but not completely
- Mammalian target of Rapamycin: discovery of Rapamycin reveals a signaling pathway important for normal and cancer cell growth
- Rapamycin ameliorates PKD resulting from conditional inactivation of Pkd1
- Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
- Mechanisms of life span extension by Rapamycin in the fruit fly Drosophila melanogaster
- Rapamycin Protects against Neuron Death in In Vitro andIn Vivo Models of Parkinson’s Disease
- Targeting mTOR with Rapamycin: one dose does not fit all
- The role of the mammalian target of Rapamycin (mTOR) in renal disease
- Mammalian target of Rapamycin (mTOR): conducting the cellular signaling symphony
- Potential use of Rapamycin in HIV infection
- Targeting mTOR globally in cancer: thinking beyond Rapamycin
- The complexes of mammalian target of Rapamycin
- The mammalian target of Rapamycin: linking T cell differentiation, function, and metabolism
- Not all substrates are treated equally: Implications for mTOR, Rapamycin-resistance, and cancer therapy
- Rapamycin-induced phosphaturia
- The mammalian target of Rapamycin signaling pathway mediates epileptogenesis in a model of temporal lobe epilepsy
- Mammalian target of Rapamycin complex 1: signalling inputs, substrates and feedback mechanisms
- Rapamycin administration in humans blocks the contraction‐induced increase in skeletal muscle protein synthesis
- Rapamycin extends maximal lifespan in cancer-prone mice
- Active-site inhibitors of mTOR target Rapamycin-resistant outputs of mTORC1 and mTORC2
- Nutrient-dependent regulation of autophagy through the target of Rapamycin pathway
- Biosynthesis of Rapamycin and its regulation: past achievements and recent progress
- inhibition of mTOR by Rapamycin abolishes cognitive deficits and reduces amyloid-β levels in a mouse model of Alzheimer’s disease
- SIRT1 negatively regulates the mammalian target of Rapamycin
- Targeting mammalian target of Rapamycin by Rapamycin prevents tumor progression in an oral-specific chemical carcinogenesis model
- Characterization of the Rapamycin-sensitive phosphoproteome reveals that Sch9 is a central coordinator of protein synthesis
- Rapamycin and quasi-programmed aging: Four years later
- A versatile role of mammalian target of Rapamycin in human dendritic cell function and differentiation
- Autophagy is required for extension of yeast chronological life span by Rapamycin
- Rapid inactivation of proteins by Rapamycin-induced rerouting to mitochondria
- Discovery of GSK2126458, a highly potent inhibitor of PI3K and the mammalian target of Rapamycin
- Ku-0063794 is a specific inhibitor of the mammalian target of Rapamycin (mTOR)
- Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss
- GOLPH3 modulates mTOR signalling and Rapamycin sensitivity in cancer
- Molecular interplay between mammalian target of Rapamycin (mTOR), amyloid-β, and Tau: effects on cognitive impairments
- A Rapamycin-sensitive signaling pathway is essential for the full expression of persistent pain states
- Resveratrol and Rapamycin: are they anti‐aging drugs?
- Metformin and Rapamycin have distinct effects on the AKT pathway and proliferation in breast cancer cells
- Biochemical, cellular, and in vivo activity of novel ATP-competitive and selective inhibitors of the mammalian target of Rapamycin
- Rapamycin protects against rotenone-induced apoptosis through autophagy induction
- Protein synthesis is resistant to Rapamycin and constitutes a promising therapeutic target in acute myeloid leukemia
- Rapamycin reduces seizure frequency in tuberous sclerosis complex
- Pharmacological inhibition of the mammalian target of Rapamycin pathway suppresses acquired epilepsy
- Preliminary characterization of oral lesions associated with inhibitors of mammalian target of Rapamycin in cancer patients
- TORC-specific phosphorylation of mammalian target of Rapamycin (mTOR): phospho-Ser2481 is a marker for intact mTOR signaling complex 2
- Total synthesis of Rapamycin
- Targeted inhibition of mammalian target of Rapamycin signaling inhibits tumorigenesis of colorectal cancer
- AZD8055 is a potent, selective, and orally bioavailable ATP-competitive mammalian target of Rapamycin kinase inhibitor with in vitro and in vivo antitumor activity
- Tti1 and Tel2 are critical factors in mammalian target of Rapamycin complex assembly
- The mTOR pathway is highly activated in diabetic nephropathy and Rapamycin has a strong therapeutic potential
- Role for mammalian target of Rapamycin complex 1 signaling in neuroadaptations underlying alcohol-related disorders
- Dual inhibition of Akt/mammalian target of Rapamycin pathway by nanoparticle albumin-bound–Rapamycin and perifosine induces antitumor activity in multiple …
- Long-term Rapamycin therapy in the Han: SPRD rat model of polycystic kidney disease (PKD)
- Delivery of Rapamycin to dendritic cells using degradable microparticles
- Ras pathway activation in hepatocellular carcinoma and anti-tumoral effect of combined sorafenib and Rapamycin in vivo
- CDC25B mediates Rapamycin-induced oncogenic responses in cancer cells
- Regulation of mTORC1 and mTORC2 complex assembly by phosphatidic acid: competition with Rapamycin
- Curcumin disrupts the Mammalian target of Rapamycin-raptor complex
- HER2YVMA drives rapid development of adenosquamous lung tumors in mice that are sensitive to BIBW2992 and Rapamycin combination therapy
- Chronic Rapamycin treatment causes glucose intolerance and hyperlipidemia by upregulating hepatic gluconeogenesis and impairing lipid deposition in adipose …
- Recent advances in the chemistry, biosynthesis and pharmacology of Rapamycin analogs
- inhibition of target of Rapamycin signaling and stress activate autophagy in Chlamydomonas reinhardtii
- Akt signals through the mammalian target of Rapamycin pathway to regulate CNS myelination
- Beneficial effects of Mammalian target of Rapamycin inhibition on left ventricular remodeling after myocardial infarction
- Mammalian target of Rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways
- Activation of the mammalian target of Rapamycin (mTOR) is essential for oligodendrocyte differentiation
- The Rapamycin-sensitive phosphoproteome reveals that TOR controls protein kinase A toward some but not all substrates
- Sorafenib and Rapamycin induce growth suppression in mouse models of hepatocellular carcinoma
- Mammalian target of Rapamycin: hitting the bull’s-eye for neurological disorders
- Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies
- Mammalian target of Rapamycin (mTOR) inhibition as a potential antiepileptogenic therapy: from tuberous sclerosis to common acquired epilepsies
- inhibition of the mammalian target of Rapamycin (mTOR) in advanced pancreatic cancer: results of two phase II studies
- A pharmacodynamic study of Rapamycin in men with intermediate-to high-risk localized prostate cancer
- Bone growth during Rapamycin therapy in young rats
- Regulation of placental amino acid transporter activity by mammalian target of Rapamycin
- Rapamycin inhibits cytoskeleton reorganization and cell motility by suppressing RhoA expression and activity
- Mammalian target of Rapamycin regulates miRNA-1 and follistatin in skeletal myogenesis
- Topical Rapamycin: a novel approach to facial angiofibromas in tuberous sclerosis
- New inhibitors of the mammalian target of Rapamycin signaling pathway for cancer
- Cutting edge: Rapamycin augments pathogen-specific but not graft-reactive CD8+ T cell responses
- Mammalian target of Rapamycin inhibitors and their potential role in therapy in leukaemia and other haematological malignancies
- Integration of general amino acid control and target of Rapamycin (TOR) regulatory pathways in nitrogen assimilation in yeast
- Specific roles of Target of Rapamycin in the control of stem cells and their progeny in the Drosophila ovary
- Down-regulation of Akt/mammalian target of Rapamycin signaling pathway in response to myostatin overexpression in skeletal muscle
- Infusion of mesenchymal stem cells and Rapamycin synergize to attenuate alloimmune responses and promote cardiac allograft tolerance
- Rapamycin suppresses seizures and neuronal hypertrophy in a mouse model of cortical dysplasia
- Rapamycin inhibition of the Akt/mTOR Pathway Blocks Select Stages of VEGF-A164–Driven Angiogenesis, in Part by Blocking S6Kinase
- Rapamycin Protects Against High Fat Diet–Induced Obesity in C57BL/6J Mice
- Rapamycin regulates stearoyl CoA desaturase 1 expression in breast cancer
- Activation of autophagy and Akt/CREB signaling play an equivalent role in the neuroprotective effect of Rapamycin in neonatal hypoxia-ischemia
- Overexpression of phosphorylated mammalian target of Rapamycin predicts lymph node metastasis and prognosis of chinese patients with gastric cancer
- Mammalian target of Rapamycin (mTOR) activation increases axonal growth capacity of injured peripheral nerves
- Rapamycin promotes β-amyloid production via ADAM-10 inhibition
- Differential responses of human regulatory T cells (Treg) and effector T cells to Rapamycin
- Monitoring mammalian target of Rapamycin (mTOR) activity
- The efficacy of the novel dual PI3-kinase/mTOR inhibitor NVP-BEZ235 compared with Rapamycin in renal cell carcinoma
- Mammalian target of Rapamycin is a critical regulator of cardiac hypertrophy in spontaneously hypertensive rats
- Treatment with Rapamycin prevents fibrosis in tight‐skin and bleomycin‐induced mouse models of systemic sclerosis
- Mammalian target of Rapamycin complex 1 suppresses lipolysis, stimulates lipogenesis, and promotes fat storage
- Regulation of RNA polymerase III transcription involves SCH9-dependent and SCH9-independent branches of the target of Rapamycin (TOR) pathway
- Mammalian target of Rapamycin controls dendritic cell development downstream of Flt3 ligand signaling
- Comparison of human and rat uterine leiomyomata: identification of a dysregulated mammalian target of Rapamycin pathway
- Long‐term administration of Rapamycin reduces adiposity, but impairs glucose tolerance in high‐fat diet‐fed KK/HlJ mice
- Rapamycin inhibits hepatic fibrosis in rats by attenuating multiple profibrogenic pathways
- Regulation of insulin-like growth factor–mammalian target of Rapamycin signaling by microRNA in childhood adrenocortical tumors
- Rapamycin prevents transforming growth factor-α–induced pulmonary fibrosis
- Participation of mammalian target of Rapamycin complex 1 in Toll-like receptor 2–and 4–induced neutrophil activation and acute lung injury
- Use of Rapamycin in the induction of tolerogenic dendritic cells
- Rapamycin versus methotrexate in early diffuse systemic sclerosis: Results from a randomized, single‐blind pilot study
- Insights into the domain and repeat architecture of target of Rapamycin
- A novel mouse model of inflammatory bowel disease links mammalian target of Rapamycin-dependent hyperproliferation of colonic epithelium to inflammation …
- Nutrient availability and lactogenic hormones regulate mammary protein synthesis through the mammalian target of Rapamycin signaling pathway
- The mammalian target of Rapamycin as novel central regulator of puberty onset via modulation of hypothalamic Kiss1 system
- … irinotecan and Rapamycin combination toward colon cancer cells in vivo and in vitro is mediated through cooperative modulation of the mammalian target of Rapamycin …
- Rapamycin rescues TDP-43 mislocalization and the associated low molecular mass neurofilament instability
- Rapamycin-resistant mTORC1 kinase activity is required for herpesvirus replication
- Mammalian target of Rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade
- Celastrol suppresses angiogenesis-mediated tumor growth through inhibition of AKT/mammalian target of Rapamycin pathway
- Critical roles for mTORC2-and Rapamycin-insensitive mTORC1-complexes in growth and survival of BCR-ABL-expressing leukemic cells
- inhibition of the mammalian target of Rapamycin signaling pathway suppresses dentate granule cell axon sprouting in a rodent model of temporal lobe epilepsy
- Oral Rapamycin attenuates inflammation and enhances stability of atherosclerotic plaques in rabbits independent of serum lipid levels
- Myxoma virus virotherapy for glioma in immunocompetent animal models: optimizing administration routes and synergy with Rapamycin
- inhibition of histone deacetylase overcomes Rapamycin-mediated resistance in diffuse large B-cell lymphoma by inhibiting Akt signaling through mTORC2
- Rapamycin promotes the osteoblastic differentiation of human embryonic stem cells by blocking the mTOR pathway and stimulating the BMP/Smad pathway
- Synergistic effect of Rapamycin and cisplatin in endometrial cancer cells
- Activation of mammalian target of Rapamycin controls the loss of TCRζ in lupus T cells through HRES-1/Rab4-regulated lysosomal degradation
- Mammalian target of Rapamycin activation underlies HSC defects in autoimmune disease and inflammation in mice
- Uremic cardiac hypertrophy is reversed by Rapamycin but not by lowering of blood pressure
- Testosterone induces cardiomyocyte hypertrophy through mammalian target of Rapamycin complex 1 pathway
- Rapamycin in islet transplantation: friend or foe?
- Mammalian target of Rapamycin complex 1 (mTORC1) activity is associated with phosphorylation of raptor by mTOR
- Rapamycin, unlike cyclosporine A, enhances suppressive functions of in vitro-induced CD4+CD25+ Tregs
- Mammalian target of Rapamycin signaling is crucial for joint destruction in experimental arthritis and is activated in osteoclasts from patients with rheumatoid arthritis
- Rapamycin has dual opposing effects on proteinuric experimental nephropathies: is it a matter of podocyte damage?
- Distinct roles for mammalian target of Rapamycin complexes in the fibroblast response to transforming growth factor-β
- Expression of an activated mammalian target of Rapamycin (mTOR) in gastroenteropancreatic neuroendocrine tumors
- The somatostatin analogue octreotide confers sensitivity to Rapamycin treatment on pituitary tumor cells
- Rapamycin regulates Akt and ERK phosphorylation through mTORC1 and mTORC2 signaling pathways
- Rapamycin potentiates the effects of paclitaxel in endometrial cancer cells through inhibition of cell proliferation and induction of apoptosis
- ATP-competitive inhibitors of the mammalian target of Rapamycin: design and synthesis of highly potent and selective pyrazolopyrimidines
- Gastric mammalian target of Rapamycin signaling regulates ghrelin production and food intake
- The potential benefits of Rapamycin on renal function, tolerance, fibrosis, and malignancy following transplantation
- Target of Rapamycin signaling in leukemia and lymphoma
- Rapamycin inhibits relapsing experimental autoimmune encephalomyelitis by both effector and regulatory T cells modulation
- Targeted inhibition of mammalian target of Rapamycin for the treatment of advanced renal cell carcinoma
- Target of Rapamycin (TOR) mediates the transduction of nutritional signals into juvenile hormone production
- Rapamycin activates autophagy and improves myelination in explant cultures from neuropathic mice
- Phase II trial of the oral mammalian target of Rapamycin inhibitor everolimus in relapsed or refractory Waldenström macroglobulinemia
- Mammalian target of Rapamycin (mTOR) regulates cellular proliferation and tumor growth in urothelial carcinoma
- The novel orally bioavailable inhibitor of phosphoinositol-3-kinase and mammalian target of Rapamycin, NVP-BEZ235, inhibits growth and proliferation in multiple …
- Mammalian target of Rapamycin: biological function and target for novel anticancer agents
- Mammalian target of Rapamycin signaling activation patterns in neuroendocrine tumors of the lung
- inhibition of mammalian target of Rapamycin as a therapeutic strategy in the management of bladder cancer
- Randomised trial of three Rapamycin-eluting stents with different coating strategies for the reduction of coronary restenosis: 2-year follow-up results
- inhibition of mammalian target of Rapamycin is required for optimal antitumor effect of HER2 inhibitors against HER2-overexpressing cancer cells
- Perifosine inhibits mammalian target of Rapamycin signaling through facilitating degradation of major components in the mTOR axis and induces autophagy
- The effect of Rapamycin on bone growth in rabbits
- Rapamycin pharmacokinetic and pharmacodynamic relationships in osteosarcoma: a comparative oncology study in dogs
- Efficacy of systemically administered oncolytic vaccinia virotherapy for malignant gliomas is enhanced by combination therapy with Rapamycin or cyclophosphamide
- Rapamycin induces transactivation of the EGFR and increases cell survival
- Mammalian target of Rapamycin inhibitors Rapamycin and RAD001 (everolimus) induce anti-proliferative effects in GH-secreting pituitary tumor cells in vitro
- Adiponectin modulates C-jun N-terminal kinase and mammalian target of Rapamycin and inhibits hepatocellular carcinoma
- B55β-associated PP2A complex controls PDK1-directed myc signaling and modulates Rapamycin sensitivity in colorectal cancer
- High entrapment efficiency of chitosan/polylactic acid/tripolyphotspate nanosized microcapsules for Rapamycin by an emulsion-evaporation approach
- Therapeutics by cytotoxic metabolite accumulation: pemetrexed causes ZMP accumulation, AMPK activation, and mammalian target of Rapamycin inhibition
- Chemical genetics screen for enhancers of Rapamycin identifies a specific inhibitor of an SCF family E3 ubiquitin ligase
- Immune regulation by Rapamycin: moving beyond T cells
- First report on a series of HIV patients undergoing Rapamycin monotherapy after liver transplantation
- … leucine content of a complete meal directs peak activation but not duration of skeletal muscle protein synthesis and mammalian target of Rapamycin signaling in rats
- Rapamycin reduces intrahepatic alpha-1-antitrypsin mutant Z protein polymers and liver injury in a mouse model
- Rapamycin inhibits in vitro growth and release of angiogenetic factors in human bladder cancer
- Mammalian target of Rapamycin signaling modulates photic entrainment of the suprachiasmatic circadian clock
- The tuberous sclerosis proteins regulate formation of the primary cilium via a Rapamycin-insensitive and polycystin 1-independent pathway
- Phospho-mTOR and phospho-4EBP1 in endometrial adenocarcinoma: association with stage and grade in vivo and link with response to Rapamycin treatment in vitro
- Different effects of FK506, Rapamycin, and mycophenolate mofetil on glucose-stimulated insulin release and apoptosis in human islets
- Downregulation of Akt/mammalian target of Rapamycin pathway in skeletal muscle is associated with increased REDD1 expression in response to chronic hypoxia
- Dual targeting of AKT and mammalian target of Rapamycin: a potential therapeutic approach for malignant peripheral nerve sheath tumor
- Mammalian target of Rapamycin in spinal cord neurons mediates hypersensitivity induced by peripheral inflammation
- Effect of Rapamycin, an mTOR inhibitor, on radiation sensitivity of lung cancer cells having different p53 gene status
- Leptin modulates the survival of autoreactive CD4+ T cells through the nutrient/energy-sensing mammalian target of Rapamycin signaling pathway
- … skeletal muscle protein synthesis via an indirect mechanism involving endothelial-dependent vasodilation and mammalian target of Rapamycin complex 1 signaling
- Signaling events downstream of mammalian target of Rapamycin complex 2 are attenuated in cells and tumors deficient for the tuberous sclerosis complex tumor …
- A phase I study of the mammalian target of Rapamycin inhibitor sirolimus and MEC chemotherapy in relapsed and refractory acute myelogenous leukemia
- Morpholine derivatives greatly enhance the selectivity of mammalian target of Rapamycin (mTOR) inhibitors
- Intravesical delivery of Rapamycin suppresses tumorigenesis in a mouse model of progressive bladder cancer
- Complex regulation of mammalian target of Rapamycin complex 1 in the basomedial hypothalamus by leptin and nutritional status
- Mammalian target of Rapamycin regulates vascular endothelial growth factor–dependent liver cyst growth in polycystin‐2–defective mice
- Rapamycin sensitizes T-ALL cells to dexamethasone-induced apoptosis
- Generation of high-yield Rapamycin-producing strains through protoplasts-related techniques
- An expeditious route to fluorinated Rapamycin analogues by utilising mutasynthesis
- Mechanisms involved in the enhancement of mammalian target of Rapamycin signalling and hypertrophy in skeletal muscle of myostatin-deficient mice
- Mammalian target of Rapamycin and diabetes: what does the current evidence tell us?
- Mammalian target of Rapamycin inhibition and alloantigen-specific regulatory T cells synergize to promote long-term graft survival in immunocompetent recipients
- Treatment of refractory oral erosive lichen planus with topical Rapamycin: 7 cases
- Cryptotanshinone inhibits cancer cell proliferation by suppressing mammalian target of Rapamycin–mediated cyclin D1 expression and Rb phosphorylation
- Tubers and tumors: Rapamycin therapy for benign and malignant tumors
- The pre-clinical assessment of Rapamycin-eluting, durable polymer-free stent coating concepts
- Rapamycin weekly maintenance dosing and the potential efficacy of combination sorafenib plus Rapamycin but not atorvastatin or doxycycline in tuberous …
- EGFR signaling through an Akt-SREBP-1–dependent, Rapamycin-resistant pathway sensitizes glioblastomas to antilipogenic therapy
- Rapamycin promotes arterial thrombosis in vivo: implications for everolimus and zotarolimus eluting stents
- Expansion of the target of Rapamycin (TOR) kinase family and function in Leishmania shows that TOR3 is required for acidocalcisome biogenesis and animal infectivity
- Long‐term blood vessel removal with combined laser and topical Rapamycin antiangiogenic therapy: Implications for effective port wine stain treatment
- R1507, a fully human monoclonal antibody targeting IGF‐1R, is effective alone and in combination with Rapamycin in inhibiting growth of osteosarcoma xenografts
- EphA2 mutation in lung squamous cell carcinoma promotes increased cell survival, cell invasion, focal adhesions, and mammalian target of Rapamycin …
- Rapamycin prevents early onset of tumorigenesis in an oral-specific K-ras and p53 two-hit carcinogenesis model
- Mammalian target of Rapamycin signaling in the spinal cord is required for neuronal plasticity and behavioral hypersensitivity associated with neuropathy in …
- Rapamycin regulates endothelial cell migration through regulation of the cyclin-dependent kinase inhibitor p27Kip1
- Activated mammalian target of Rapamycin is a potential therapeutic target in gastric cancer
- Mutual regulation of hypoxia-inducible factor and mammalian target of Rapamycin as a function of oxygen availability
- Rapamycin selectively inhibits expression of an inducible keratin (K6a) in human keratinocytes and improves symptoms in pachyonychia congenita patients
- Rapamycin inhibits postprandial-mediated X-box-binding protein-1 splicing in rat liver
- inhibition of human T-cell proliferation by mammalian target of Rapamycin (mTOR) antagonists requires noncoding RNA growth-arrest-specific transcript 5 (GAS5)
- Mammalian target of Rapamycin is activated in association with myometrial proliferation during pregnancy
- Expression status and prognostic significance of mammalian target of Rapamycin pathway members in urothelial carcinoma of urinary bladder after cystectomy
- A phase 2 study of the oral mammalian target of Rapamycin inhibitor, everolimus, in patients with recurrent endometrial carcinoma
- Mammalian target of Rapamycin (mTOR) regulates TLR3 induced cytokines in human oral keratinocytes
- Rapamycin-mediated FOXO1 inactivation reduces the anticancer efficacy of Rapamycin
- Rapamycin for refractory acute graft-versus-host disease
- Life span extension by resveratrol, Rapamycin, and metformin: The promise of dietary restriction mimetics for an healthy aging
- Nucleus accumbens core mammalian target of Rapamycin signaling pathway is critical for cue-induced reinstatement of cocaine seeking in rats
- New approach for local delivery of Rapamycin by bioadhesive PLGA-carbopol nanoparticles
- Activation of the mammalian target of Rapamycin signalling pathway in prostate cancer and its association with patient clinicopathological characteristics
- … triterpenoid, suppresses migration and invasion of human breast cancer cells by modulating c‐Jun N‐terminal kinase, Akt and mammalian target of Rapamycin …
- Rapamycin induces autophagic flux in neurons
- Development and characterization of liposomal formulations for Rapamycin delivery and investigation of their antiproliferative effect on MCF7 cells
- A pilot trial of the mTOR (mammalian target of Rapamycin) inhibitor RAD001 in patients with advanced B-CLL
- Survival benefit with proapoptotic molecular and pathologic responses from dual targeting of mammalian target of Rapamycin and epidermal growth factor …
- Pyrazolopyrimidines as highly potent and selective, ATP-competitive inhibitors of the mammalian target of Rapamycin (mTOR): Optimization of the 1-substituent
- A randomized optical coherence tomography study of coronary stent strut coverage and luminal protrusion with Rapamycin-eluting stents
- The target of Rapamycin complex 2 controls dendritic tiling of Drosophila sensory neurons through the Tricornered kinase signalling pathway
- Mammalian target of Rapamycin signaling and autophagy: roles in lymphangioleiomyomatosis therapy
- Rapamycin (sirolimus) in tuberous sclerosis associated pediatric central nervous system tumors
- Targeted therapy of human osteosarcoma with 17AAG or Rapamycin: characterization of induced apoptosis and inhibition of mTOR and Akt/MAPK/Wnt pathways
- Conversion to Rapamycin immunosuppression for malignancy after kidney transplantation
- cAMP-dependent activation of mammalian target of Rapamycin (mTOR) in thyroid cells. Implication in mitogenesis and activation of CDK4
- Immunosuppression using the mammalian target of Rapamycin (mTOR) inhibitor everolimus: pilot study shows significant cognitive and affective improvement
- Late progression of renal pathology and cyst enlargement is reduced by Rapamycin in a mouse model of nephronophthisis
- Targeting melanoma with dual phosphoinositide 3-kinase/mammalian target of Rapamycin inhibitors
- Oral Rapamycin reduces tumour burden and vascularization in Lkb1+/− mice
- Rapamycin and MPA, but not CsA, impair human NK cell cytotoxicity due to differential effects on NK cell phenotype
- NVP-BEZ235, a novel dual phosphatidylinositol 3-kinase/mammalian target of Rapamycin inhibitor, elicits multifaceted antitumor activities in human gliomas
- Broadening the therapeutic scope for Rapamycin treatment
- Dual phosphoinositide 3-kinase/mammalian target of Rapamycin blockade is an effective radiosensitizing strategy for the treatment of non–small cell lung cancer …
- Upregulation of the mammalian target of Rapamycin complex 1 pathway by Ras homolog enriched in brain in pancreatic β-cells leads to increased β-cell mass and …
- mTORC1 inhibition via Rapamycin promotes triacylglycerol lipolysis and release of free fatty acids in 3T3-L1 adipocytes
- Mammalian target of Rapamycin activator RHEB is frequently overexpressed in human carcinomas and is critical and sufficient for skin epithelial carcinogenesis
- Effects of metformin on mammalian target of Rapamycin in a mouse model of endometrial hyperplasia
- Rapamycin inhibits oncogenic intestinal ion channels and neoplasia in APC Min/+ mice
- Fission yeast TORC1 regulates phosphorylation of ribosomal S6 proteins in response to nutrients and its activity is inhibited by Rapamycin
- Early and late effects of the immunosuppressants Rapamycin and mycophenolate mofetil on UV carcinogenesis
- Curcumin inhibits carcinogen and nicotine-induced Mammalian target of Rapamycin pathway activation in head and neck squamous cell carcinoma
- Differing effects of systemically administered Rapamycin on consolidation and reconsolidation of context vs. cued fear memories
- The antidepressant sertraline inhibits translation initiation by curtailing mammalian target of Rapamycin signaling
- Vascular endothelial growth factor-C protects prostate cancer cells from oxidative stress by the activation of mammalian target of Rapamycin complex-2 and AKT-1
- Rapamycin-induced Gln3 dephosphorylation is insufficient for nuclear localization: Sit4 and PP2A phosphatases are regulated and function differently
- Melatonin attenuates methamphetamine‐induced deactivation of the mammalian target of Rapamycin signaling to induce autophagy in SK‐N‐SH cells
- Monotherapy Rapamycin allows an increase of CD4+ CD25bright+ FoxP3+ T cells in renal recipients
- Rapamycin: the cure for all that ails
- Activation of mammalian target of Rapamycin signaling in spatial learning
- Dual inhibition of mitogen-activated protein kinase kinase and mammalian target of Rapamycin in differentiated and anaplastic thyroid cancer
- Comparison of radiosensitizing effects of the mammalian target of Rapamycin inhibitor CCI-779 to cisplatin in experimental models of head and neck squamous cell …
- The emerging role of the phosphatidylinositol 3-kinase/Akt/mammalian target of Rapamycin signaling network in normal myelopoiesis and leukemogenesis
- MYC activity mitigates response to Rapamycin in prostate cancer through eukaryotic initiation factor 4E–binding protein 1–mediated inhibition of autophagy
- Successful control of intractable hypoglycemia using Rapamycin in an 86-year-old man with a pancreatic insulin-secreting islet cell tumor and metastases
- Generation of high Rapamycin producing strain via rational metabolic pathway‐based mutagenesis and further titer improvement with fed‐batch bioprocess …
- Activity of the novel dual phosphatidylinositol 3-kinase/mammalian target of Rapamycin inhibitor NVP-BEZ235 against T-cell acute lymphoblastic leukemia
- Rapamycin-Insensitive Up-Regulation of MMP2 and Other Genes in Tuberous Sclerosis Complex 2–Deficient Lymphangioleiomyomatosis-Like Cells
- Increasing longevity through caloric restriction or Rapamycin feeding in mammals: common mechanisms for common outcomes?
- Rapamycin inhibits anal carcinogenesis in two preclinical animal models
- Overexpression of the mammalian target of Rapamycin: a novel biomarker for poor survival in resected early stage non-small cell lung cancer
- Mammalian target of Rapamycin complex 1-mediated phosphorylation of eukaryotic initiation factor 4E-binding protein 1 requires multiple protein–protein interactions …
- Downregulation of Notch pathway by a γ-secretase inhibitor attenuates AKT/mammalian target of Rapamycin signaling and glucose uptake in an ERBB2 transgenic …
- A phosphatidylinositol 3-kinase/protein kinase B-independent activation of mammalian target of Rapamycin signaling is sufficient to induce skeletal muscle hypertrophy
- … -1, 3, 5-triazine) derivatives: potent adenosine 5′-triphosphate competitive phosphatidylinositol-3-kinase/mammalian target of Rapamycin inhibitors: discovery of …
- Rapamycin enhances LPS induction of tissue factor and tumor necrosis factor-α expression in macrophages by reducing IL-10 expression
- Rapamycin protects mice from staphylococcal enterotoxin B-induced toxic shock and blocks cytokine release in vitro and in vivo
- Pneumonitis associated with mammalian target of Rapamycin inhibitors in renal transplant recipients: a single-center experience
- Discovery of potent and selective inhibitors of the mammalian target of Rapamycin (mTOR) kinase
- Antimyeloma activity of the orally bioavailable dual phosphatidylinositol 3-kinase/mammalian target of Rapamycin inhibitor NVP-BEZ235
- Rapamycin inhibits IGF-1 stimulated cell motility through PP2A pathway
- Mammalian target of Rapamycin is a biomarker of poor survival in metastatic serous ovarian carcinoma
- Involvement of heterogeneous ribonucleoprotein F in the regulation of cell proliferation via the mammalian target of Rapamycin/S6 kinase 2 pathway
- Treatment with Rapamycin ameliorates clinical and histological signs of protracted relapsing experimental allergic encephalomyelitis in Dark Agouti rats and induces …
- Rapamycin and CCI‐779 inhibit the mammalian target of Rapamycin signalling in hepatocellular carcinoma
- mTOR Ser-2481 autophosphorylation monitors mTORC-specific catalytic activity and clarifies Rapamycin mechanism of action
- Preclinical in vivo evaluation of Rapamycin in human malignant peripheral nerve sheath explant xenograft
- Hypersensitivity of Ph-positive lymphoid cell lines to Rapamycin: Possible clinical application of mTOR inhibitor
- Mammalian target of Rapamycin complex 1 is involved in differentiation of regenerating myofibers in vivo
- Rapamycin as a therapy of choice after renal transplantation in a patient with tuberous sclerosis complex
- Treating triple-negative breast cancer by a combination of Rapamycin and cyclophosphamide: an in vivo bioluminescence imaging study
- Antitumoral activity of Rapamycin mediated through inhibition of HIF-1alpha and VEGF in hepatocellular carcinoma
- Aberrant hyperactivation of akt and Mammalian target of Rapamycin complex 1 signaling in sporadic chordomas
- HIV-associated nephropathy: role of mammalian target of Rapamycin pathway
- The Rapamycin-regulated gene expression signature determines prognosis for breast cancer
- … acid starvation of Saccharomyces cerevisiae and Candida albicans acetolactate synthase (ilv2Δ) mutants is influenced by the carbon source and Rapamycin
- Combined Bcl-2/Mammalian Target of Rapamycin inhibition Leads to Enhanced Radiosensitization via Induction of Apoptosis and Autophagy in Non–Small Cell Lung …
- Rapamycin down-regulates inducible nitric oxide synthase by inducing proteasomal degradation
- Functional interaction of mammalian target of Rapamycin complexes in regulating mammalian cell size and cell cycle
- Efficacy, tolerance, and safety of mammalian target of Rapamycin inhibitors as rescue immunosuppressants in liver transplantation
- Rapamycin induces the TGFβ1/Smad signaling cascade in renal mesangial cells upstream of mTOR
- … 3-kinase (PI3K) and the mammalian target of Rapamycin (mTOR): design, synthesis, and superior antitumor activity of novel wortmannin− Rapamycin conjugates
- Developing antiepileptogenic drugs for acquired epilepsy: targeting the mammalian target of Rapamycin (mTOR) pathway
- Hepatitis C virus NS5A activates the mammalian target of Rapamycin (mTOR) pathway, contributing to cell survival by disrupting the interaction between …
- Naive CD4 t cell proliferation is controlled by mammalian target of Rapamycin regulation of GRAIL expression
- Activation of the mammalian target of Rapamycin signalling pathway in epidermal tumours and its correlation with cyclin‐dependent kinase 2
- The effects of Rapamycin on lens epithelial cell proliferation, migration, and matrix formation: an in vitro study
- Distinct phosphatase requirements and GATA factor responses to nitrogen catabolite repression and Rapamycin treatment in Saccharomyces cerevisiae
- Rapamycin induces growth retardation by disrupting angiogenesis in the growth plate
- … protects mouse and human hematopoietic progenitors from γ-irradiation through extracellular signal-regulated kinase/mammalian target of Rapamycin …
- Rapamycin inhibits cell proliferation in type I and type II endometrial carcinomas: a search for biomarkers of sensitivity to treatment
- Dramatic improvement in pulmonary hypertension with Rapamycin
- High expression of mammalian target of Rapamycin is associated with better outcome for patients with early stage lung adenocarcinoma
- Phase Ib study of weekly mammalian target of Rapamycin inhibitor ridaforolimus (AP23573; MK-8669) with weekly paclitaxel
- Expression of EBV latent antigens, mammalian target of Rapamycin, and tumor suppression genes in EBV-positive smooth muscle tumors: clinical and therapeutic …
- Identification of functional FKB protein in Echinococcus granulosus: its involvement in the protoscolicidal action of Rapamycin derivates and in calcium homeostasis
- The role of phosphoinositide 3‐kinase and phosphatidic acid in the regulation of mammalian target of Rapamycin following eccentric contractions
- Placental mammalian target of Rapamycin and related signaling pathways in an ovine model of intrauterine growth restriction
- Rapamycin inhibits proliferation and migration of hepatoma cells in vitro
- TSC1 loss synergizes with KRAS activation in lung cancer development in the mouse and confers Rapamycin sensitivity
- Rapamycin response in tumorigenic and non-tumorigenic hepatic cell lines
- Activation of the AKT and mammalian target of Rapamycin pathways and the inhibitory effects of Rapamycin on those pathways in canine malignant melanoma cell lines
- Rapamycin as an alternative to surgical treatment of subependymal giant cell astrocytomas in a patient with tuberous sclerosis complex: Case report
- Rapamycin-eluting stents in the arterial duct: experimental observations in the pig model.
- Device-based local delivery of siRNA against mammalian target of Rapamycin (mTOR) in a murine subcutaneous implant model to inhibit fibrous encapsulation
- mTOR inhibitor Rapamycin alone or combined with cisplatin inhibits growth of esophageal squamous cell carcinoma in nude mice
- Exploring mammalian target of Rapamycin (mTOR) inhibition for treatment of mantle cell lymphoma and other hematologic malignancies
- Target of Rapamycin (TOR)-like 1 kinase is involved in the control of polyphosphate levels and acidocalcisome maintenance in Trypanosoma brucei
- Rapid modification of proteins using a Rapamycin-inducible tobacco etch virus protease system
- Concurrent and sequential administration of chemotherapy and the Mammalian target of Rapamycin inhibitor temsirolimus in human cancer cells and xenografts
- Mammalian target of Rapamycin complex 1 (mTORC1) signaling in energy balance and obesity
- Bortezomib can suppress activation of Rapamycin-resistant memory T cells without affecting regulatory T-cell viability in non-human primates
- Rapamycin Prevents and Breaks the Anti-CD3–Induced Tolerance in NOD Mice
- Rapamycin generates anti-apoptotic human Th1/Tc1 cells via autophagy for induction of xenogeneic GVHD
- Polylactide-glycoli acid and Rapamycin coating intraocular lens prevent posterior capsular opacification in rabbit eyes
- Regulation of cell death and epileptogenesis by the mammalian target of Rapamycin (mTOR): a double-edged sword?
- Rapamycin inhibits growth of cholangiocarcinoma cells.
- The Insulin-like Growth Factor-1 Receptor–Targeting Antibody, CP-751,871, Suppresses Tumor-Derived VEGF and Synergizes with Rapamycin in Models of …
- Rapamycin induces autophagy in islets: relevance in islet transplantation
- Mammalian target of Rapamycin inhibition abrogates insulin-mediated mammary tumor progression in type 2 diabetes
- Long-term clinical results following stenting of the left main stem: insights from RESEARCH (Rapamycin-Eluting Stent Evaluated at Rotterdam Cardiology Hospital) …
- Rapamycin by itself and additively in combination with carboplatin inhibits the growth of ovarian cancer cells
- Evaluation of in vivo antineoplastic effects of Rapamycin in patients with chemotherapy-refractory AML
- Expression and mechanism of mammalian target of Rapamycin in age-related renal cell senescence and organ aging
- Rapid improvement of nephrogenic systemic fibrosis with Rapamycin therapy: possible role of phospho-70-ribosomal-S6 kinase
- Inactivation of mammalian target of Rapamycin increases STAT1 nuclear content and transcriptional activity in α4-and protein phosphatase 2A-dependent …
- Testing intravitreal toxicity of Rapamycin in rabbit eyes
- Antagonism of the mammalian target of Rapamycin selectively mediates metabolic effects of epidermal growth factor receptor inhibition and protects human malignant …
- ATP-mediated protein kinase B Akt/mammalian target of Rapamycin mTOR/p70 ribosomal S6 protein p70S6 kinase signaling pathway activation promotes …
- Delayed re-endothelialization with Rapamycin-coated stents is rescued by the addition of a glycogen synthase kinase-3β inhibitor
- Regulation of gene expression in hepatic cells by the mammalian Target of Rapamycin (mTOR)
- inhibition of mammalian target of Rapamycin signaling potentiates the effects of all‐trans retinoic acid to induce growth arrest and differentiation of human acute …
- Rapamycin enhances chemotherapy‐induced cytotoxicity by inhibiting the expressions of TS and ERK in gastric cancer cells
- Pilot study: Rapamycin in advanced hepatocellular carcinoma
- Mammalian target of Rapamycin as a novel target in the treatment of hepatocellular carcinoma.
- Mammalian target of Rapamycin: a new target in prostate cancer
- MAPK, phosphatidylinositol 3-kinase, and mammalian target of Rapamycin pathways converge at the level of ribosomal protein S6 phosphorylation to control metabolic …
- Rapamycin delays tumor development in murine livers by inhibiting proliferation of hepatocytes with DNA damage
- The Rapamycin-derivative RAD001 (everolimus) inhibits cell viability and interacts with the Akt–mTOR–p70S6K pathway in human medullary thyroid carcinoma cells
- Rapamycin and the transcription factor C/EBPβ as a switch in osteoclast differentiation: implications for lytic bone diseases
- Mammalian target of Rapamycin (mTOR) is involved in the survival of cells mediated by chemokine receptor 7 through PI3K/Akt in metastatic squamous cell carcinoma …
- Rapamycin inhibits lung metastasis of B16 melanoma cells through down‐regulating alphav integrin expression and up‐regulating apoptosis signaling
- Mammalian target of Rapamycin (mTOR) induces proliferation and de-differentiation responses to three coordinate pathophysiologic stimuli (mechanical strain …
- PKI-179: an orally efficacious dual phosphatidylinositol-3-kinase (PI3K)/mammalian target of Rapamycin (mTOR) inhibitor
- Effect of Rapamycin on lifespan in Drosophila
- Luteinizing hormone stimulates mammalian target of Rapamycin signaling in bovine luteal cells via pathways independent of AKT and mitogen-activated protein kinase …
- The effect of Rapamycin on angiogenesis in chick chorioalantoic membrane
- Mammalian target of Rapamycin pathway promotes tumor-induced angiogenesis in adenoid cystic carcinoma: its suppression by isoliquiritigenin through dual …
- Regulation of gastric hormones by systemic Rapamycin
- Effect of combination treatment of Rapamycin and isoflavones on mTOR pathway in human glioblastoma (U87) cells
- Distinct subsets of Sit4 holophosphatases are required for inhibition of Saccharomyces cerevisiae growth by Rapamycin and zymocin
- Activation of phosphatidylinositol 3-kinase/Akt-mammalian target of Rapamycin signaling pathway in the hippocampus is essential for the acquisition of morphine …
- Rapamycin inhibits re-endothelialization after percutaneous coronary intervention by impeding the proliferation and migration of endothelial cells and …
- Critical and diverse involvement of Akt/mammalian target of Rapamycin signaling in human lung carcinomas
- … yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a Highly Potent, Selective Mammalian Target of Rapamycin (mTOR) Inhibitor for …
- Phosphoinositide 3-kinase (PI3K) and the nutrient sensing mTOR (mammalian target of Rapamycin) pathways control T cell migration
- Glycogen synthase kinase-3 and mammalian target of Rapamycin pathways contribute to DNA synthesis, cell cycle progression, and proliferation in human islets
- Periadventitial Rapamycin-eluting microbeads promote vein graft disease in long-term pig vein-into-artery interposition grafts
- Inhibitory effect of Rapamycin and dexamethasone on production of IL-17 and IFN-γ in Vogt–Koyanagi–Harada patients
- Rap1 promotes multiple pancreatic islet cell functions and signals through mammalian target of Rapamycin complex 1 to enhance proliferation
- Novel mechanism of reducing tumourigenesis: upregulation of the DNA repair enzyme OGG1 by Rapamycin-mediated AMPK activation and mTOR inhibition
- Rapamycin‐Conditioned Donor Dendritic Cells Differentiate CD4+CD25+Foxp3+ T Cells In Vitro with TGF‐β1 for Islet Transplantation
- Mammalian Target of Rapamycin–Dependent Acinar Cell Neoplasia after Inactivation of Apc and Pten in the Mouse Salivary Gland: Implications for Human Acinic Cell …
- The Drosophila FoxA ortholog Fork head regulates growth and gene expression downstream of Target of Rapamycin
- Rescue immunosuppression with mammalian target of Rapamycin inhibitor drugs in liver transplantation
- In-vitro release of Rapamycin from a thermosensitive polymer for the inhibition of vascular smooth muscle cell proliferation
- Influence of combined treatment of low dose Rapamycin and cyclosporin A on corneal allograft survival
- Low-dose Rapamycin reduces kidney volume angiomyolipomas and prevents the loss of renal function in a patient with tuberous sclerosis complex
- Rapamycin attenuates the severity of murine adriamycin nephropathy
- Rapamycin and curcumin induce apoptosis in primary resting B chronic lymphocytic leukemia cells
- Stage 2 combination testing of Rapamycin with cytotoxic agents by the Pediatric Preclinical Testing Program
- Targeting the mammalian target of Rapamycin to inhibit VEGF and cytokines for the treatment of primary effusion lymphoma
- Human Protein Phosphatase PP6 Regulatory Subunits Provide Sit4-Dependent and Rapamycin–Sensitive Sap Function in Saccharomyces cerevisiae
- … cell marker upregulation in normal cutaneous vessels following pulsed‐dye laser exposure and its abrogation by concurrent Rapamycin administration: implications for …
- Monitoring kidney and renal cyst volumes applying MR approaches on a Rapamycin treated mouse model of ADPKD
- Rapamycin promotes the expansion of CD4+ Foxp3+ regulatory T cells after liver transplantation
- … cells treated with mammalian target of Rapamycin inhibitors: rationale for combined treatment with extracellular signal–regulated kinase inhibitors and Rapamycin
- Effective treatment of advanced colorectal cancer by Rapamycin and 5-FU/oxaliplatin monitored by TIMP-1
- Anti-CD154 mAb and Rapamycin induce T regulatory cell mediated tolerance in rat-to-mouse islet transplantation
- Rictor phosphorylation on the Thr-1135 site does not require mammalian target of Rapamycin complex 2
- Comparison of three Rapamycin dosing schedules in A/J Tsc2+/-mice and improved survival with angiogenesis inhibitor or asparaginase treatment in mice …
- Effect of Rapamycin on cue-induced drug craving in abstinent heroin addicts
- Adenosine 5′-monophosphate-activated protein kinase-mammalian target of Rapamycin cross talk regulates brown adipocyte differentiation
- Intracellular parasitism with Toxoplasma gondii stimulates mammalian‐target‐of‐Rapamycin‐dependent host cell growth despite impaired signalling to S6K1 and 4E …
- Dual inhibition of class IA phosphatidylinositol 3-kinase and mammalian target of Rapamycin as a new therapeutic option for T-cell acute lymphoblastic leukemia
- The synergic effects of Rapamycin and extremely low frequency electromagnetic field on angiogenesis
- Rapamycin therapy for renal, brain, and skin lesions in a tuberous sclerosis patient
- Rapamycin effects on mTOR signaling in benign, premalignant and malignant human breast epithelial cells
- Combined inhibition of MEK and mammalian target of Rapamycin abolishes phosphorylation of cyclin-dependent kinase 4 in glioblastoma cell lines and prevents their …
- Structural basis for the association of the redox-sensitive target of Rapamycin FATC domain with membrane-mimetic micelles
- NV‐128, a novel isoflavone derivative, induces caspase‐independent cell death through the Akt/mammalian target of Rapamycin pathway
- Activating transcription factor 4 and CCAAT/enhancer-binding protein-β negatively regulate the mammalian target of Rapamycin via Redd1 expression in response to …
- Epidermal growth factor receptor and mammalian target of Rapamycin as therapeutic targets in malignant glioma: current clinical status and perspectives
- Chemopreventive efficacy of Rapamycin on Peutz–Jeghers syndrome in a mouse model
- … Stents Results in Better Clinical Outcomes During 6-Year Follow-Up Than Bare-Metal Stents: An Analysis of the RESEARCH (Rapamycin-Eluting Stent Evaluated At …
- … repair-deficient colorectal cancers highlight the potential therapeutic role of inhibitors of the phosphatidylinositol 3-kinase-AKT-mammalian target of Rapamycin …
- … of the epidermal growth factor receptor/mammalian target of Rapamycin pathway by epidermal growth factor receptor inhibitors and Rapamycin results in reduced cell …
- inhibition of the mammalian target of Rapamycin promotes cyclic AMP-induced differentiation of NG108-15 cells
- Human CD34-derived myeloid dendritic cell development requires intact phosphatidylinositol 3-kinase–protein kinase B–mammalian target of Rapamycin signaling
- The emerging role of the phosphatidylinositol 3-kinase/Akt/mammalian target of Rapamycin signaling network in cancer stem cell biology
- … -6-aryl-1H-pyrazolo[3,4-d]pyrimidines as Highly Potent and Selective ATP-Competitive Inhibitors of the Mammalian Target of Rapamycin (mTOR): Optimization of the …
- PI3K signaling regulates Rapamycin-insensitive translation initiation complex formation in vaccinia virus-infected cells
- Silymarin inhibits endothelial progenitor cells’ senescence and protects against the antiproliferative activity of Rapamycin: preliminary study
- inhibition of voltage-gated K+ channels in dendritic cells by Rapamycin
- Phase I study of the oral mammalian target of Rapamycin inhibitor everolimus (RAD001) in Japanese patients with relapsed or refractory non-Hodgkin lymphoma
- Regulation by FK506 and Rapamycin of Ca2+ release from the sarcoplasmic reticulum in vascular smooth muscle: the role of FK506 binding proteins and mTOR
- … using bare-metal and drug-eluting stents in previously untreated coronary artery disease: insights from the RESEARCH (Rapamycin-Eluting Stent Evaluated at …
- Rrd1 isomerizes RNA polymerase II in response to Rapamycin
- Tuberous sclerosis complex suppression in cerebellar development and medulloblastoma: separate regulation of mammalian target of Rapamycin activity and p27Kip1 …
- Rapamycin impairs metabolism-secretion coupling in rat pancreatic islets by suppressing carbohydrate metabolism
- If mammalian target of metformin indirectly is mammalian target of Rapamycin, then the insulin-like growth factor-1 receptor axis will audit the efficacy of metformin in …
- The transcription factor SP1 regulates centriole function and chromosomal stability through a functional interaction with the mammalian target of Rapamycin/raptor …
- Involvement of autophagy via mammalian target of Rapamycin (mTOR) inhibition in tributyltin-induced neuronal cell death
- Rapamycin protects heart from ischemia/reperfusion injury independent of autophagy by activating PI3 kinase-Akt pathway and mitochondria KATP channel
- … peroxisome proliferator-activated receptor (PPAR) γ protein translation by suppressing the mammalian target of Rapamycin (mTOR) signaling pathway in …
- SP600125 negatively regulates the mammalian target of Rapamycin via ATF4-induced Redd1 expression
- … in the phosphoinositide 3-kinase/Akt signaling pathway confer sensitivity of thyroid cancer cells to therapeutic targeting of Akt and mammalian target of Rapamycin
- Rapamycin Inhibits VEGF‐Induced Microvascular Hyperpermeability In Vivo
- Iron deficiency down-regulates the Akt/TSC1-TSC2/mammalian Target of Rapamycin signaling pathway in rats and in COS-1 cells
- Interactome mapping of the phosphatidylinositol 3-kinase-mammalian target of Rapamycin pathway identifies deformed epidermal autoregulatory factor-1 as a …
- Bim is the key mediator of glucocorticoid-induced apoptosis and of its potentiation by Rapamycin in human myeloma cells
- Rapamycin for focal segmental glomerulosclerosis: a report of 3 cases
- inhibition of mammalian target of Rapamycin (mTOR) signalling in C2C12 myoblasts prevents myogenic differentiation without affecting the hyperphosphorylation of 4E …
- Regression of left ventricular hypertrophy in kidney transplant recipients: the potential role for inhibition of mammalian target of Rapamycin
- … by leucine supplementation in malnourished rats: possible involvement of the phosphatidylinositol 3-phosphate kinase/mammalian target protein of Rapamycin …
- Rapamycin inhibits cholangiocyte regeneration by blocking interleukin‐6–induced activation of signal transducer and activator of transcription 3 after liver …
- A role for mammalian target of Rapamycin–mTOR-pathway in non alcoholic steatohepatitis related-cirrhosis
- Targeting mammalian target of Rapamycin to both downregulate and disable the P-glycoprotein pump in multidrug-resistant B-cell lymphoma cell lines
- Severe rhabdomyolysis and acute renal failure secondary to concomitant use of simvastatin with Rapamycin plus tacrolimus in liver transplant patient
- Rapamycin promotes the enrichment of CD4+ CD25hiFoxP3+ T regulatory cells from naive CD4+ T cells of baboon that suppress antiporcine xenogenic response in …
- Rapamycin, but not cyclosporine A, inhibits vascularization and incorporation of implanted surgical meshes
- Rapamycin‐treated mature dendritic cells have a unique cytokine secretion profile and impaired allostimulatory capacity
- Rapamycin induces autophagy and exacerbates metabolism associated complications in a mouse model of type 1 diabetes
- Effective inhibition of xenografts of hepatocellular carcinoma (HepG2) by Rapamycin and bevacizumab in an intrahepatic model
- Inducible somatic oocyte destruction in response to Rapamycin requires wild-type regulation of follicle cell epithelial polarity
- Cutaneous T‐cell lymphoma cells are sensitive to Rapamycin
- … ligand mediates follicular lymphoma B-cell proliferation and cyclin D1 expression through phosphatidylinositol 3-kinase–regulated mammalian target of Rapamycin …
- Mammalian target of Rapamycin (mTOR) and S6 kinase down-regulate phospholipase D2 basal expression and function
- Rapamycin enhances the susceptibility of both androgen-dependent and-independent prostate carcinoma cells to docetaxel
- The phosphatidylinositol 3-kinase-AKT-mammalian target of Rapamycin signaling network and the control of normal myelopoiesis
- CD4+ Foxp3+ regulatory T cells converted by Rapamycin from peripheral CD4+ CD25˜. naive T cells display more potent regulatory abilityin vitro
- Chemistry and pharmacology of Rapamycin and its derivatives
- Combining the receptor tyrosine kinase inhibitor AEE788 and the mammalian target of Rapamycin (mTOR) inhibitor RAD001 strongly inhibits adhesion and …
- Mammalian target of the Rapamycin pathway is involved in non-alcoholic fatty liver disease
- Antiproliferative effects of Rapamycin and celecoxib in angiosarcoma cell lines
- Phase 1 and pharmacokinetic study of everolimus, a mammalian target of Rapamycin inhibitor, in combination with docetaxel for recurrent/refractory nonsmall cell lung …
- mTOR inhibitor Rapamycin suppresses striatal post-ischemic LTP
- Ribosomal protein S6 kinase is a critical downstream effector of the target of Rapamycin complex 1 for long-term facilitation in Aplysia
- FK506 and Rapamycin neuroprotect erection and involve different immunophilins in a rat model of cavernous nerve injury
- Rapamycin increases the p53/MDM2 protein ratio and p53-dependent apoptosis by translational inhibition of mdm2 in cancer cells
- MCF-7 breast cancer cells selected for tamoxifen resistance acquire new phenotypes differing in DNA content, phospho-HER2 and PAX2 expression, and Rapamycin …
- Lysosomal accumulation of mTOR is enhanced by Rapamycin
- Systemic Rapamycin without loading dose for restenosis prevention after coronary bare metal stent implantation
- Beclin 1 self‐association is independent of autophagy induction by amino acid deprivation and Rapamycin treatment
- High expression levels of the mammalian target of Rapamycin inhibitor DEPTOR are predictive of response to thalidomide in myeloma
- … of the effects of NF-κB or PI3K pathway inhibitors on the LPS-induced gene expression profile in RAW264. 7 cells: synergistic effects of Rapamycin on LPS-induced …
- Combined administration of a mutant TGF-β1/Fc and Rapamycin promotes induction of regulatory T cells and islet allograft tolerance
- Evidence for cell cycle-dependent, Rapamycin-resistant phosphorylation of ribosomal protein S6 at S240/244
- Rapamycin reduces high-amplitude, mechanical stretch-induced apoptosis in pulmonary microvascular endothelial cells
- Effect of low-dose Rapamycin on tumor growth in two human hepatocellular cancer cell lines
- The serine 2481-autophosphorylated form of mammalian Target Of Rapamycin (mTOR) is localized to midzone and midbody in dividing cancer cells
- Rapamycin: could it enhance vaccine efficacy?
- Rapamycin and tacrolimus differentially modulate acute graft‐versus‐host disease in rats after liver transplantation
- Infarct size is increased in female post-MI rats treated with Rapamycin
- Protein kinase C-δ and phosphatidylinositol 3-kinase/Akt activate mammalian target of Rapamycin to modulate NF-κB activation and intercellular adhesion …
- Glutamate-dependent phosphorylation of the mammalian target of Rapamycin (mTOR) in Bergmann glial cells
- Rapid regression of lymphadenopathy upon Rapamycin treatment in a child with autoimmune lymphoproliferative syndrome
- Lead optimization of N-3-substituted 7-morpholinotriazolopyrimidines as dual phosphoinositide 3-kinase/mammalian target of Rapamycin inhibitors: discovery of PKI …
- mTOR, the mammalian target of Rapamycin
- Oral Rapamycin attenuates atherosclerosis without affecting the arterial responsiveness of resistance vessels in apolipoprotein E-deficient mice
- Glucagon acts in a dominant manner to repress insulin-induced mammalian target of Rapamycin complex 1 signaling in perfused rat liver
- Targeting heat‐shock protein 90 improves efficacy of Rapamycin in a model of hepatocellular carcinoma in mice
- Rapamycin, the mTOR kinase inhibitor, sensitizes acute myeloid leukemia cells, HL-60 cells, to the cytotoxic effect of arabinozide cytarabine
- inhibition of human immunodeficiency virus (HIV‐1) infection in human peripheral blood leucocytes‐SCID reconstituted mice by Rapamycin
- Mammalian target of Rapamycin activity is required for expansion of CD34+ hematopoietic progenitor cells
- Effects of Rapamycin on prostate cancer PC-3 cells
- Five‐year clinical outcomes after coronary stenting of chronic total occlusion using sirolimus‐eluting stents: Insights from the Rapamycin‐eluting stent evaluated at …
- … of essential amino acid deficiency in the anterior piriform cortex, that requires the uncharged tRNA/GCN2 pathway, is sensitive to wortmannin but not Rapamycin
- Failed rescue therapy with Rapamycin after paraquat intoxication
- mTOR pathway inhibitors in cancer therapy: moving past Rapamycin
- A spectrophotometric assay for routine measurement of mammalian target of Rapamycin activity in cell lysates
- Rhabdomyolysis and acute kidney injury secondary to concomitant use of fluvastatin and Rapamycin in a renal transplant recipient
- Rapamycin in combination with donor-specific CD4+ CD25+ Treg cells amplified in vitro might be realize the immune tolerance in clinical organ transplantation
- Shiga toxin 1-induced proinflammatory cytokine production is regulated by the phosphatidylinositol 3-kinase/Akt/mammalian target of Rapamycin signaling pathway
- Triazines incorporating (R)-3-methylmorpholine are potent inhibitors of the mammalian target of Rapamycin (mTOR) with selectivity over PI3Kα
- Timing of conversion to mammalian target of Rapamycin inhibitors is crucial in liver transplant recipients with impaired renal function at transplantation
- Novel benzofuran-3-one indole inhibitors of PI3 kinase-α and the mammalian target of Rapamycin: Hit to lead studies
- Fission yeast TOR and Rapamycin
- Activated mammalian target of Rapamycin is associated with T regulatory cell insufficiency in nasal polyps
- Rapamycin or tacrolimus alone fails to resist cardiac allograft accelerated rejection mediated by alloreactive CD4+ memory T cells in mice
- A functional link between polo-like kinase 1 and the mammalian target-of-Rapamycin pathway?
- The combination of multiple receptor tyrosine kinase inhibitor and mammalian target of Rapamycin inhibitor overcomes erlotinib resistance in lung cancer cell lines …
- Experience with everolimus (RAD001), an oral mammalian target of Rapamycin inhibitor, in patients with systemic mastocytosis
- Antitumor efficacy profile of PKI-402, a dual phosphatidylinositol 3-kinase/mammalian target of Rapamycin inhibitor
- Rapamycin impairs trabecular bone acquisition from high‐dose but not low‐dose intermittent parathyroid hormone treatment
- Steady-state kinetic and inhibition studies of the mammalian target of Rapamycin (mTOR) kinase domain and mTOR complexes
- Rapamycin inhibits hepatectomy-induced stimulation of metastatic tumor growth by reduction of angiogenesis, microvascular blood perfusion, and tumor cell …
- Impact of mammalian target of Rapamycin inhibition on autosomal-dominant polycystic kidney disease
- Limited utility of Rapamycin in severe, refractory Wegener’s granulomatosis
- Rescuing 3T3-L1 adipocytes from insulin resistance induced by stimulation of Akt-mammalian target of Rapamycin/p70 S6 kinase (S6K1) pathway and serine …
- MYC activity mitigates response to Rapamycin in prostate cancer through 4EBP1-mediated inhibition of autophagy
- Target of Rapamycin in the oriental fruit fly Bactrocera dorsalis (hendel): its cloning and effect on yolk protein expression
- Rapamycin enhances aplaviroc anti-HIV activity: implications for the clinical development of novel CCR5 antagonists
- Reducing the risk of left ventricular hypertrophy in kidney transplant recipients: the potential role of mammalian target of Rapamycin
- Molecular pathways involved in hair follicle tumor formation: all about mammalian target of Rapamycin?
- Posttransplantation Therapeutic Rapamycin Concentration Protects Nitric Oxide–Related Vascular Endothelial Function: Comparative Effects in Rat Thoracic Aorta …
- Controversies in breast cancer: the mammalian target of Rapamycin as a target for breast cancer therapy
- WJD008, a dual phosphatidylinositol 3-kinase (PI3K)/mammalian target of Rapamycin inhibitor, prevents PI3K signaling and inhibits the proliferation of transformed …
- AZD6244 (ARRY‐142886) enhances the antitumor activity of Rapamycin in mouse models of human hepatocellular carcinoma
- Increased frequency of regulatory T cells and selection of highly potent CD62L+ cells during treatment of human lung transplant recipients with Rapamycin
- Comparison of Rapamycin-and paclitaxel-eluting stents in patients undergoing primary percutaneous coronary intervention for ST-elevation myocardial infarction
- Regulation of protein kinase Cδ downregulation by protein kinase Cε and mammalian target of Rapamycin complex 2
- Rapamycin reduces proteinuria and renal damage in the rat remnant kidney model
- How does the mammalian target of Rapamycin (mTOR) influence CD8 T-cell differentiation?
- Alteration of REDD1-mediated mammalian target of Rapamycin pathway and hypoxia-inducible factor-1α regulation in human breast cancer
- Immunohistochemical analysis of the mammalian target of Rapamycin signalling pathway in extramammary Paget’s disease
- Preventing restenosis after implantation of bare stents with oral Rapamycin: a randomized angiographic and intravascular ultrasound study with a 5-year clinical follow …
- Rapamycin can Inhibit the Development of Chlamydia pneumoniae, which Might Partly Contribute to the Prevention of In-stent Restenosis
- Depletion of mammalian target of Rapamycin (mTOR) via siRNA mediated knockdown leads to stabilization of β-catenin and elicits distinct features of …
- Indirect antitumor effects of mammalian target of Rapamycin inhibitors against Kaposi sarcoma in transplant patients
- … -pyrrolo [2, 3-b] pyridin-3-yl) methylene-4-hydroxybenzofuran-3 (2H)-ones as potent and selective ATP-competitive inhibitors of the mammalian target of Rapamycin …
- Inhibitors of the mammalian target of Rapamycin and transplant tolerance
- Clinical implications of proteinuria in renal transplant recipients switching to Rapamycin for chronic allograft dysfunction
- Transforming growth factor beta 1 (TGF-β1) and Rapamycin synergize to effectively suppress human T cell responses via upregulation of FoxP3+ Tregs
- Descending serotonergic facilitation mediated by spinal 5-HT3 receptors engages spinal Rapamycin-sensitive pathways in the rat
- … replacement in 6-aryl-1H-pyrazolo [3, 4-d] pyrimidines and 2-arylthieno [3, 2-d] pyrimidines: ATP-competitive inhibitors of the mammalian target of Rapamycin (mTOR)
- Mycophenolate mofetil versus Rapamycin in Han: SPRD rats with polycystic kidney disease
- Rapamycin sensitizes Akt inhibition in malignant human breast epithelial cells
- Protection from Rapamycin-induced apoptosis by insulin-like growth factor-I is partially dependent on protein kinase C signaling
- Suppression of mTOR complex 2‐dependent AKT phosphorylation in melanoma cells by combined treatment with Rapamycin and LY294002
- Antitumour activity of a potent MEK inhibitor RDEA119/BAY 869766 combined with Rapamycin in human orthotopic primary pancreatic cancer xenografts
- Effects of delayed Rapamycin treatment on renal fibrosis and inflammation in experimental ischemia reperfusion injury
- Cutting edge: Expression of the transcription factor E74-like factor 4 is regulated by the mammalian target of Rapamycin pathway in CD8+ T cells
- Loss of inhibitory insulin receptor substrate-1 phosphorylation is an early event in mammalian target of Rapamycin–dependent endometrial hyperplasia and carcinoma
- Rapamycin inhibits yeast nucleotide excision repair independently of Tor kinases
- ID2‐VEGF‐related Pathways in the Pathogenesis of Kaposi’s Sarcoma: A Link Disrupted by Rapamycin
- Phosphorylation of translation factors in response to anoxia in turtles, Trachemys scripta elegans: role of the AMP-activated protein kinase and target of Rapamycin …
- Novel mechanism of Rapamycin in GVHD: increase in interstitial regulatory T cells
- Low-dose calcineurin inhibitor regimen combined with mammalian target of Rapamycin inhibitors preserves kidney functions in renal transplant recipients without …
- Rapamycin for chemoprevention of upper aerodigestive tract cancers
- Mutation of a phosphorylatable residue in Put3p affects the magnitude of Rapamycin-induced PUT1 activation in a Gat1p-dependent manner
- Spreading of mesothelioma cells is Rapamycin‐sensitive and requires continuing translation
- Rapamycin enhances platelet aggregation induced by adenosine diphosphate in vitro
- Insulin resistance without elevated mammalian target of Rapamycin complex 1 activity in muscles of mice fed a high-fat diet
- 4-Substituted-7-azaindoles bearing a ureidobenzofuranone moiety as potent and selective, ATP-competitive inhibitors of the mammalian target of Rapamycin (mTOR)
- Serine 2481-autophosphorylation of mammalian target of Rapamycin (mTOR) couples with chromosome condensation and segregation during mitosis: Confocal …
- Mammalian target of Rapamycin inhibition prevents glomerular hypertrophy in a model of renal mass reduction
- Select nutrients in the ovine uterine lumen. VI. Expression of FK506-binding protein 12-Rapamycin complex-associated protein 1 (FRAP1) and regulators and effectors …
- The effect of Rapamycin liposome gutta inhibiting rat corneal neovascularization
- Retracted: CCR5 blockade in combination with Rapamycin prolongs cardiac allograft survival in mice
- Rapamycin joins the aging fray: maybe Ponce de Leon visited Rapa Nui, not Florida
- Adenovirus-mediated eukaryotic initiation factor 4E binding protein-1 in combination with Rapamycin inhibits tumor growth of pancreatic ductal adenocarcinoma in vivo
- Effective targeting of STAT5-mediated survival in myeloproliferative neoplasms using ABT-737 combined with Rapamycin
- Rapamycin does not adversely affect intrahepatic islet engraftment in mice and improves early islet engraftment in humans
- Late conversion to mammalian target of Rapamycin inhibitor/proliferation signal inhibitors in kidney transplant patients: clinical experience in the last 5 years
- … between a prospective randomised multicentre cutting balloon angioplasty and bare metal stent trial (REDUCE III) and the Rapamycin-Eluting Stent Evaluation At …
- … growth inhibition is augmented by synchronous inhibition of the insulin-like growth factor-1 receptor by NVP-AEW541 and inhibition of mammalian target of Rapamycin …
- Rapamycin suppresses the expansion and differentiation of porcine neonatal pancreas cell clusters
- The possible cellular mechanism for extending lifespan of mice with Rapamycin
- Rapamycin reduces kidney volume and delays the loss of renal function in a patient with autosomal-dominant polycystic kidney disease
- … posttranscriptional regulation of insulin-like growth factor-I receptor level via glycogen synthase kinase-3β and mammalian target of Rapamycin in adrenal chromaffin …
- Preparation of electrospun poly (L-lactide-co-caprolactone-co-glycolide)/phospholipid polymer/Rapamycin blended fibers for vascular application
- Combined effect of Rapamycin and cisplatin on survival of Hep-2 cells in vitro
- Adenosine-triphosphate promoting repair of spinal cord injury by activating mammalian target of Rapamycin/signal transducers and activators of transcription 3 signal …
- Mammalian target of Rapamycin complex 1 signaling opposes the effects of anchorage loss, leading to activation of Cdk4 and Cdc6 stabilization
- Rapamycin for Kaposi’s sarcoma and graft-versus-host disease in bone marrow transplant recipient
- Rapamycin instead of mycophenolate mofetil or azathioprine in treatment of post-renal transplantation urothelial carcinoma
- First-in-man use of polymer-free valsartan-eluting stents in small coronary vessels: a comparison to polymer-free Rapamycin (2%)-eluting stents
- Mammalian target of Rapamycin and autosomal dominant polycystic kidney disease
- Rapamycin-induced proteinuria following allogeneic hematopoietic stem cell transplantation
- Effect of Rapamycin on leukemia cell lines
- inhibition of IGF-I receptor signaling in combination with Rapamycin or temsirolimus increases MYC-N phosphorylation
- Role of GLUT1 in the Mammalian Target of Rapamycin Pathway: Mechanisms of Regulation.
- Exendin-4 protects pancreatic beta cells from the cytotoxic effect of Rapamycin by inhibiting JNK and p38 phosphorylation
- inhibition of mammalian target of Rapamycin (mTOR) in advanced pancreatic cancer: The results of two prospective phase II studies
- Monitoring Molecular-Specific Pharmacodynamics of Rapamycin In vivo with Inducible Gal4→ Fluc Transgenic Reporter Mice
- Combination of tipifarnib and Rapamycin synergistically inhibits the growth of leukemia cells and overcomes resistance to tipifarnib via alteration of cellular signaling …
- Pretreatment with intraluminal Rapamycin nanoparticle perfusion inhibits neointimal hyperplasia in a rabbit vein graft model
- Rapamycin prevents Concanavalin A‐induced liver injury by inhibiting lymphocyte activation
- Treatment algorithms in metastatic renal cell carcinoma, including the potential role of the novel oral mammalian target of Rapamycin inhibitor Everolimus
- Cyclooxygenase 2 mediates the antiangiogenic effect of Rapamycin in Ewing sarcoma
- Rapamycin selectively reduces the association of transcripts containing complex 5′ UTRs with ribosomes in C4‐2B prostate cancer cells
- Regioselective lipase-catalyzed acylation of 41-desmethoxy-Rapamycin without vinyl esters
- Rapamycin inhibits poly (ADP-ribosyl) ation in intact cells
- Early loss of mammalian target of Rapamycin complex 1 (mTORC1) signalling and reduction in cell size during dominant-negative suppression of hepatic …
- Combination Regimens of nab-Rapamycin (ABI-009) Effective Against MDA-MB-231 Breast-Tumor Xenografts.
- Rapamycin Inhibits Activator Protein-1 But Not Nuclear Factor-κB Activity of Mature Bone Marrow-Derived Dendritic Cells
- Autosomal dominant polycystic kidney disease (ADPKD): Rapamycin as a new treatment option
- Synthesis of the northern sector (C8–C19) of Rapamycin via Chan rearrangement and oxidation of an α-acyloxyacetate
- Rapamycin and thalidomide treatment of a patient with refractory metastatic gastroesophageal adenocarcinoma: a case report
- Effects of Rapamycin on Breast Cancer Cell Migration through the Cross-Talk of MAPK Pathway.
- inhibition of mammalian target of Rapamycin: the janus face of immunosuppression?
- Effect of Rapamycin on proliferated human umbilical vein endothelial cell
- … 5‐(2‐chloroethyl)‐2‐acetoxy‐benzyl]‐4‐(2‐chloroethyl)‐phenyl acetate inhibits phosphoinositide 3‐kinase/Akt/mammalian target of Rapamycin signalling through JNK …
- Progression of graft fibrosis under mammalian target of Rapamycin inhibitor‐based regimen
- Effects of Rapamycin on the differentiation and function of macrophages in vitro
- Monotherapy Rapamycin in renal transplant recipients with lymphoma successfully treated with rituximab
- Rapamycin enhances lipopolysaccharide-induced apoptosis and lung injury
- Rapamycin treatment suppresses epileptogenic activity in conditional Pten knockout mice
- Influence of Rapamycin on autophagy and apoptosis of two lepidoptera cell lines.
- Effect of Rapamycin on proliferation of acute myeloid leukemia cell lines HL-60 and HL-60/VCR
- A phase II trial of a mammalian target of Rapamycin inhibitor, temsirolimus, in patients with metastatic breast cancer.
- Molecular pathways in metastatic renal cell carcinoma: the evolving role of mammalian target of Rapamycin inhibitors
- Anti-insulin-like growth factor-1 receptor (IGF-IR) monoclonal antibody cixutumumab plus mammalian target of Rapamycin (mTOR) inhibitor temsirolimus in metastatic …
- Effect of Rapamycin and Cyclosporin A on the expression of TLR5 and Foxp3 in allorejection
- Combination therapy of 5-fluorouracil with Rapamycin for hormone receptor-negative human breast cancer
- … of D-cyclin translation inhibition in myeloma cells treated with mTOR inhibitors: rationale for combined treatment with ERK inhibitors and Rapamycin
- Dual inhibition of Akt/mTOR pathway by nab-Rapamycin and perifosine induces anti-tumor activity in multiple myeloma
- Forever young, slim and fit: Rapamycin to the rescue
- Evaluation of a Rapamycin‐regulated serotype 2 adeno‐associated viral vector in macaque parotid glands
- Recent developments of Rapamycin analogues
- Combination of Rapamycin and IL-2 do not affect antigen presentation ability of rat B cell and could promote Tregs proliferation and inhibitory activity
- Mammalian target of Rapamycin: MasTOR mediator of cellular changes in pathological states?
- Use of a cocktail regimen consisting of soluble galectin-1, Rapamycin and histone deacetylase inhibitor may effectively prevent type 1 diabetes
- Identification of Akt-selective cytotoxic compounds that enhance cytotoxic responses to Rapamycin
- Mammalian target of Rapamycin, Akt, and phosphatidylinositol 3-kinase signaling
- Prevention of hepatic tumor growth and metastasis in rats with Rapamycin
- Effect of Rapamycin on apoptosis in human myelodysplastic syndrome cell line MUTZ-1 and its possible mechanisms
- A phase I dose-finding and pharmacodynamic study of Rapamycin in combination with bevacizumab in patients with unresectable hepatocellular carcinoma.
- Antitumor activity, and antiangiogenic activity of nanoparticle albumin-bound nab-Rapamycin in combination with nab-paclitaxel.
- Mammalian target of Rapamycin (mTOR)-induced pneumonitis: Single-institution experience and treatment.
- inhibition of cell growth by Rapamycin through targeting mammalian target of Rapamycin signaling pathway in nasopharyngeal carcinoma
- Study advance of Rapamycin in the field of transplantation immunology [J]
- Release test of Rapamycin in drug-eluting stents
- The mechanism and influence of Rapamycin on proliferation of NIH3T3 fibroblasts transfected with mTOR gene [J]
- Effects of Rapamycin on angiogenesis and tumor progression in human hepatocellular carcinoma implantation mice
- Correlation factors of vascular restenosis and safety following Rapamycin drug-eluting stent implantation
- Mammalian target of Rapamycin, its mode of action and clinical response in metastatic clear cell carcinoma
- Regulation of bone formation using Rapamycin-induced BMP2 expression system: influence of implanted cell number
- Active-site inhibitors of mTOR target Rapamycin-resistant outputs of mTORC1 and mTORC2, PLoS Biol
- Effect of Rapamycin on proliferation, apoptosis and regulation of chemokine receptor CXCR4 in RPMI8226 cells
- Abstract C62: Identification of GSK2126458, a highly potent inhibitor of phosphoinositide 3‐kinase (PI3K) and the mammalian target of Rapamycin (mTOR)
- Rapamycin and HIV Replication in Liver Transplant Recipients
- Effects of Rapamycin-loaded poly (lactic-co-glycolic) acid nanoparticles on distribution of cell cycle, expression of p27 protein, and proliferation of human umbilical …
- Rapamycin induces apoptosis of lung adenocarcinoma cell A549 under hypoxia and its molecular mechanism
- A phase I study of sirolimus (Rapamycin) and bevacizumab in patients with advanced malignancies.
- Effects of Rapamycin on collagen type Ⅰ expression in rat myocardial cell induced by CVB 3
- Abstract C65: Enhanced antitumor effect by the combination of a PI3K inhibitor ZSTK474 with an mTOR inhibitor Rapamycin
- A stimulating new role for Rapamycin
- Synergistic augmentation of cisplatin-induced apoptosis in HeLa cells by Rapamycin
- Evaluation for synergistic suppression of breast cancer proliferation by Chloroquine in combination with the Rapamycin derivative, Rad001
- Rapamycin enhances lifespan: At last, an advantage for transplant recipients?
- Rapamycin reverses glucocorticoid resistance in human T-cell acute lymphoblastic leukemia CEM-C1 cells [J]
- Effects of Rapamycin on nephropathy of diabetic rats and expressions of vascular endothelial growth factor and its receptor [J]
- Interference of mTOR expression enhances sensitivity of esophageal squamous cell carcinoma EC9706 cells to Rapamycin
- Can phosphatidylinositol 3-kinase/mammalian target of Rapamycin inhibition ERase them all?
- Tuberous Sclerosis Complex and the Mammalian Target of Rapamycin Pathways
- Comparison of the MEIA and HPLC assays for the measurement of Rapamycin concentration in blood of recipients after renal transplantation [J]
- Effects of simvastatin on Rapamycin-treated cardiac microvascular endothelial cells
- Combined Rapamycin eye drop in nanometer vector and poly (lactic acid) wafers of cyclosporine A effectively prevents high-risk corneal allograft rejection in rabbits
- Mammalian target of Rapamycin inhibitors in the treatment of malignancy after organ transplantation
- Target of Rapamycin modulators of and use thereof
- Essential Role of Mammalian Target of Rapamycin (mTOR) in LH-dependent Testosterone Production in Rat Leydig Cells.
- Rapamycin inhibits growth and metastasis of gallbladder cancer GBC-SD cells.
- Pharmacological studies of a novel inhibitor of the mammalian target of Rapamycin (mTOR) signaling pathway
- Effects of Rapamycin on mTOR/p70S6K signaling pathway and tumor growth in xenografted esophageal squamous cell carcinoma.
- Effect of Rapamycin (serolimus) on in vitro cultured human keratinocytes
- Mesenchymal stem cells combined with Rapamycin immuno-regulates the spleniclymphocytes in allogenic mice.
- Effect of Rapamycin on the interaction between Salmonella typhi plasmid pR_ (ST98) and macrophages [J]
- Expression of JAK/STAT signal transduction pathway and the effects of Rapamycin in lupus nephritis-prone MRL/lpr mice
- CIRCULATING CD4CD25 HIGH CD127 LOW REGULATORY T-CELLS AFTER INTRACORONARY IMPLANTATION OF Rapamycin-ELUTING STENTS: PP. 2.73
- Preparation and production efficiency of Rapamycin ointment
- The influence of coronary stenting with Rapamycin-eluting stents on the number of circulating CD4+ CD25high+ regulatory T-cells
- Effect of Rapamycin on Phenotype of Vascular Smooth Muscle Cell and Arterial Intimal Hyperplasia in Rat Cardiac Allograft
- Mammalian target of Rapamycin inhibitors in clinical practice: Case reports of everolimus in renal cell carcinoma
- Application of stereocontrolled aldol coupling to synthesis of segments of immunosuppressants FK-506 and Rapamycin
- Abstract C63: Biological characterization of GSK2126458, a novel and potent inhibitor of phosphoinositide 3‐kinase and the mammalian target of Rapamycin (mTOR)
- Current perspectives in metastatic renal cell carcinoma treatment: the role of mammalian target of Rapamycin (mTOR) inhibition
- Rapamycin decreases proinflammatory and profibrogenic gene expression in experimental NASH
- Expression of mammalian target of Rapamycin and eIF4E signal pathway in cerebral glioma and its clinical significance [J]
- Conditional protein stabilization via the small molecules Shld-1 and Rapamycin increases the signal-to-noise ratio with tet-inducible gene expression
- A case of Kaposi’s sarcoma in the Rapamycin era
- OSI-027, a potent and selective small molecule mTORC1/mTORC2 kinase Inhibitor is mechanistically distinct from Rapamycin
- eIF4E Expression Predicts Apoptosis in Response to Epidermal Growth Factor Receptor inhibition and Mammalian Target of Rapamycin inhibition in Triple Negative …
- Rapamycin and PD98059 collaborative inhibit mammalian target of Rapamycin pathway in the prevention and treatment of mouse colorectal cancer
- Effect of Rapamycin on the growth of hepatocellular carcinoma in nude mice
- Rapamycin-based GvHD prophylaxis after T-cell replete unmanipulated haploidentical peripheral stem cell transplantation for advanced leukaemias: preliminary …
- Effect of Rapamycin administration in humans on the skeletal muscle protein anabolic response to essential amino acid ingestion
- Differential Regulation of TLR4-Mediated TNF-a Release by Mammalian Target of Rapamycin and Glycogen Synthase Kinase-3 in Alveolar Macrophages from …
- A newly developed Rapamycin-eluting stent with a biodegradable polymer reduces neointimal formation while allowing greater endothelialization
- CONVERSION TO LOW DOSE TACROLIMUS OR Rapamycin 3 MONTHS AFTER KIDNEY TRANSPLANT: A PROSPECTIVE, PROTOCOL BIOPSY GUIDED STUDY …
- The Effect of Rapamycin on Cardiac Allograft Vasculopathy in Rats
- Abstract A94: effects of different modes of calorie restriction on mammalian target of Rapamycin (mTOR) and IGF-I signaling pathways in mammary fat pads and tumors
- Rapamycin-Based GvHD Prophylaxis Is Effective in T-Cell Replete Unmanipulated Haploidentical Peripheral Stem Cell Transplantation for Advanced Haematological …
- Role of Rapamycin in renal ischemia-reperfusion injury
- Symbol Domestic Rapamycin-eluted stent for treatment of acute myocardial infarction in 108 cases
- Rapamycin Used in Kidney Transplantation Patients in China: A Meta-analysis of Clinical Curative Effects
- Conversion to Rapamycin in liver transpant recipients with renal insufficiency
- Genomewide Profiling of Rapamycin Sensitivity in Saccharomyces cerevisiae on Synthetic Medium
- Effect of Rapamycin (serolimus) on in vitro cultured human oral mucosa keratinocytes
- Effects of Rapamycin and paclitaxel on different human prostate cancer cells and xenografts
- The Generation of Novel Fluorinated Rapamycin Analogues
- Treg and Rapamycin effects on humoral immunity in young and old mice (84.12)
- EXPERIENCE WITH Rapamycin IN PEDIATRIC LIVER TRANSPLANTATION: 1434
- Inhibitory effect of Rapamycin on proliferation of H_ (22) hepatic cancer in mice
- Effect of Rapamycin on Postoperative Fibrosis After Filtration Surgery in a Rabbit Model
- The mammalian target of Rapamycin in translation and folding
- Effect of Rapamycin on the proliferation and apoptosis of glomerular mesangial cells
- Transcriptional Profile Changes Induced by Rapamycin in Breast Cancer Maintained in Organ Culture.
- Ex Vivo Manufacture of Rapamycin-Resistant Human Th1/Tc1 Cells.
- Effect of Rapamycin on regulator T cells induced by TGF-β1 in vitro
- Study of long-term safety and efficacy of domestic Firebird Rapamycin-eluting stent
- The Role of Mammalian Target of Rapamycin in the Early Development of Mouse Zygotes
- Efficacy of Rapamycin drug-eluting stents in elderly patients with coronary heart disease
- Insights into hepatic carcinogenesis: The effect of Rapamycin on rat liver cell lines
- Rapamycin combined with cisplatin in inhibiting the proliferation of ovarian cancer SKOV-3 cells [J]
- Development of Selective Inhibitors of the Mammalian Target of Rapamycin
- Rapamycin is a potent inhibitor of skin tumor promotion by TPA
- Antiproliferative and antiangiogenic effect of Rapamycin on ADPKD cystic lining epithelial cells
- Abstract B141: Effects of AZD8055, a novel mTOR kinase inhibitor, in human cancer cells developing resistance to Rapamycin
- Abstract A41: Evaluation of maximum tolerated dose of aerosolized Rapamycin in A/J mice
- Rapamycin combined with nimuatine suppresses growth and proliferation of human U87MG glioma cells
- Effect of mTOR inhibition by Rapamycin on promotion of skin tumors in BK5. Aktwt transgenic mice
- Characterization of the Effects and Functions of Sumoylation Through Rapamycin-Mediated Heterodimerization
- Black and white: Rapamycin as a regulator of cardiac mTOR signaling
- Immunomodulatory Effect of Rapamycin on Innate Immune Response Genes
- Clenbuterol increases PGC1a promoter activity via a Rapamycin sensitive mechanism
- Active-Site inhibition of the Mammalian Target of Rapamycin
- Effect of Rapamycin on cell prolification of glomerular mesangial cells by high glucose
- The role of mammalian target of Rapamycin complex 1 in hepatic physiology and disease
- Anti-Leukemia Effect of Rapamycin Alone or Plus Daunorubicin on Acute Lymphoblastic Leukemia Cell Lines
- Rapamycin reduces primary effusion lymphoma progression by targeting VEGF production and VEGF responses
- A Combined Approach of Classical Mutagenesis and Rational Metabolic Engineering for the Improved Production of Rapamycin in Streptomyces hygroscopicus …
- Rapamycin-Induced Abundance Changes in the Proteome of Budding Yeast
- Inhibitory effect of Rapamycin on human renal tubular epithelial-myofibroblast transition
- Rapamycin sensitizes Jurkat T-ALL cells to dexamethasone-induced apoptosis
- Effects of Rapamycin on cell proliferation and apoptosis of melanoma B-16 cells
- The influence of Rapamycin combined with 5-Aza-cdR to interfere in the in vitro culture of MCF-7 cell line
- Mammalian Target of Rapamycin Signaling in Regulation of Aging of Human RPE
- The therapeutic value of Rapamycin in a novel mouse model for tuberous scelrosis
- Novel therapeutic strategy for breast cancer: mammalian target of Rapamycin inhibition
- Effects of Rapamycin on growth and mTOR/4EBP1 Signalling Pathway in Xenograft of Esophageal Squamous Cell Carcinoma
- Comparison of Rapamycin and Mitomycin for Reduction of Postoperative Fibrosis After Filtration Surgery in a Rabbit Model
- Rapamycin enhances G protein signaling in the budding yeast Saccharomyces Cerevisiae
- Pharmacokinetics characterization of Rapamycin ointment in rabbit aqueous humor
- Effects of Rapamycin on nephropathy and expression of VEGF and VEGF receptors in PAN nephritic mice [J]
- … Rapamycin Combination toward Colon Cancer Cells In vivo and In vitro Is Mediated through Cooperative Modulation of the MammalianTarget of Rapamycin …
- The Regulation of STAT1 Nuclear Content by Mammalian Target of Rapamycin
- Mammalian Target of Rapamycin Regulates STAT1 Localization in Lung Epithelial Cells.
- Rapamycin-Induced Allograft Tolerance: Elucidating Mechanisms and Biomarker Discovery
- Rapamycin prevents the post‐exercise increase in protein synthesis and alters cell signaling in human skeletal muscle
- The Rapamycin-sensitive phosphoproteome reveals that TOR controls PKA 3 toward some but not all substrates 4
- CLONING AND CHARACTERIZATION OF THE PARTIAL Rapamycin-BIOSYNTHETIC GENE CLUSTER FROM ACTINOPLANES SP. N902-109
- Expression of mammalian target of Rapamycin/P70S6K in pathologic scars
- Rapamycin‐sensitive Co‐localization of mTOR to the Mitotic Spindle
- Abstract B143: Distinct antitumor mechanisms of VEGFR inhibitor tivozanib (AV‐951) and mTOR inhibitor Rapamycin support rational combination for solid tumors to …
- Effectiveness of Rapamycin drug-eluting stent (Excel stent) in treatment of patients with coronary artery disease
- Defining the clinical role of the mammalian target of Rapamycin (mTOR) in lung cancer
- BETA-CATENIN TARGET GENES ARE UPREGULATED DURING PARTIAL BLADDER OUTLET OBSTRUCTION AND INHIBITED BY Rapamycin
- Effect of Rapamycin on TGF-β1-induced epithelial-mesenchymal transition in LoVo colonic adenocarcinoma cells
- Tolerability of the mTOR inhibitor Rapamycin in cirrhotic patients with advanced hepatocellular carcinoma
- Clinical Application of Domestic Rapamycin-Eluting Stent in the Emergency Intervention of Acute Coronary Syndrome (ACS)
- Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss
- Effect of Rapamycin on regulating Toll-like receptor-4 gene expression in rats with acute liver failure
- The influence of Rapamycin on expression of CCR7 in the rats with renal fibrosis induced by adriamycin
- Rapamycin induces proliferation of CD4~+ CD25~+ FoxP3~+ T regulatory cells in rats
- Mammalian target of Rapamycin complex 2 regulates helper T cell differentiation and function (47.31)
- BLADDER SMOOTH MUSCLE CELL GROWTH IS MEDIATED BY MAMMALIAN TARGET OF Rapamycin (mTOR)
- Expression and significance of phosphorylation-mammalian target of Rapamycin in endometrial carcinoma
- High Levels Of Mammalian Target Of Rapamycin (mTOR) In Pulmonary Hypertension
- Transscleral Passive Delivery of Rapamycin in Rabbit Using a Visulex® Topical Application Device
- Inhibitory effect of Rapamycin on connective tissue growth factor-stimulated cell proliferation and fibronectin secretion in myofibroblasts
- Treatment of malignant gliomas with systemic Rapamycin and convection-enhanced delivery of nanoliposomal CPT-11
- e0519 Rapamycin suppress KrÜppel-Like Factor 2 expression: mechanism of endothelial dysfunction associated with drug-eluting stents
- The mammalian target of Rapamycin inhibitor RAD001 (everolimus) in early breast cancer
- Mammalian target of Rapamycin inhibitors for the targeted therapy of non-small cell lung cancer
- Chronic Rapamycin Therapy Ameliorates Hypertrophy and Systolic Dysfunction in Severe Chronic Heart Failure Due to Pressure Overload
- Physiologic Stimulation Of Bladder Smooth Muscle Cell Growth Is Mediated By Mammalial Target Of Rapamycin (mTOR)
- Treatment of Non-left Main Bifurcation Lesions Using the Rapamycin-Eluting Stent
- Determination of Encapsulation Efficiency of Rapamycin-loaded Poly (lactic-co-glycolic) acid Nanoparticles by HPLC
- Elucidation of chemopreventive effects of aerosolized Rapamycin and dietary myoinositol by mechanistic biomarkers in mouse lung
- Expansion of CD3+/CD4+/CD25+/Foxp3+ T cells in Rapamycin-treated lupus patients (143.52)
- Mammalian target of Rapamycin (mTOR) inhibitors with therapeutic potential for colitis
- PATHOLOGICAL ANGIOGENESIS IN VASCULAR TUMORS IS DRIVEN BY AKT1 AND INHIBITED BY TOPICAL Rapamycin
- Combination Of Simvastatin And Rapamycin Abrogates TSC2-null Tumor Growth In Nude Mice And Improves Animal Survival
- Pathological angiogenesis in vascular tumors is driven by endothelial Akt1 and inhibited by Rapamycin
- Effect of intravenous injection of apoptotic cells combined with Rapamycin on regulatory T cells in rhesus monkey
- Rapamycin Inhibits Store-Operated Ca2+ Entry in Cells Isolated from Endarterectomized Tissues of Patients with Chronic Thromboembolic Pulmonary Hypertension.
- Immune regulatory effect of Rapamycin and cyclosporine A on experimental corneal allograft survival
- Effect of Rapamycin Eluting Stent for inhibition of Neointimal Hyperplasia in Diabetic Porcine Model
- Supplemental Information Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster
- Effects of high glucose and Rapamycin intervention on expression of type Ⅳ collagen and matrix metalloproteinase-9 in podocytes
- Cigarette Smoke And Rapamycin Up-regulate Matrix Metalloproteinase-1 Expression In Endothelial Cells Through mTOR Activation
- Preparation and in vitro release study of Rapamycin in poly (lactic-co-glycolic) acid microsphere for topical administration
- PDGFR alpha is overexpressed in synovial sarcomas and can mediate Rapamycin induced Akt activation
- Enhanced tumor cytotoxicity of a combinational therapy using liposomal copper-doxorubicin, Rapamycin, and ultrasound
- Rapamycin-CONDITIONED HUMAN DENDRITIC CELLS EXHIBIT INCREASED IL-12P70 PRODUCTION UPON EXPOSURE TO PRO-INFLAMMATORY …
- Rapamycin eye drops inhibit rat corneal neovascularization: Role of vascular endothelial growth factor and inflammatory factor☆
- The mammalian target of Rapamycin signaling pathway in bovine mammary epithelial cells
- Characterisation of the effects and mechanism of action of Rapamycin and genistein on acute myeloid leukemia using high-throughput techniques
- New Drug Development in Sarcoma: Exploration of Novel Targets, Particularly the Mammalian Target of Rapamycin (mTOR) Pathway
- 45A: TARGETED SITE SPECIFIC IMMUNOSUPPRESSION WITH TOPICAL Rapamycin AND MYCOPHENOLIC ACID IN COMPOSITE TISSUE …
- 1, 4-phenylenebis (methylene) selenocyanate (p-XSC) inhibits mammalian target of Rapamycin complex 2 (mTORC2) signaling in prostate cancer cells
- Pre-clinical and Clinical Study Results for the Coracto™ Rapamycin-eluting Stent–A New-generation Drug-eluting Stent
- The Protective Effect of mammalian Target of Rapamycin (mTOR) in Cisplatin Induced Nephropathy
- Contact-dependent suppression pathways in non-human primate Tregs expanded ex vivo in the presence of Rapamycin (141.36)
- The effects of l-leucine, contractions, and Rapamycin on the Akt/mTOR pathway in rat skeletal muscle
- Rapamycin IMPAIRS PROLIFERATION OF TRANSPLANTED ISLET BETA CELLS: 791
- Rapamycin inhibits epidermal cell proliferation in a xenograft model of tuberous sclerosis skin tumors
- Effect of the combination of retinoic acid and Rapamycin on cerebellar granule cell and medulloblastoma proliferation
- Nutrient signaling, mammalian target of Rapamycin and ovine conceptus development
- Effect of combination of CCR5 antisense peptide nucleic acid and lose-dose Rapamycin on islet allograft survival
- Rapamycin inhibits cyst growth, IGF-1-mediated VEGF secretion and cell proliferation in polycystin-2 defective mice
- Is Oral Rapamycin Plus Bare Metal Stents a Feasible Alternative to Drug‐Eluting Stents? Lessons Learned from Argentina Observational and Randomized Studies …
- Rapamycin-Induced Autophagy Generates Anti-Apoptotic Th1/Tc1 Cells That Mediate Increased Xenogeneic Gvhd.
- Rapamycin impairs metabolism-secretion coupling in rat pancreatic islets by suppressing carbohydrate metabolism in the Krebs cycle
- Combination of antagonists of growth hormone-releasing hormone antagonist (GHRH) with Rapamycin as a potential therapy in human breast cancers.
- Role of mammalian target of Rapamycin signalling in bone destruction by gingival squamous cell carcinoma
- Rapamycin potentiates the effects of paclitaxel in uterine papillary serous carcinoma (UPSC) cells through inhibition of cell proliferation and induction of apoptosis
- Symbol Effect of Rapamycin-poly (lactide-acid)/magnetic microsphere composite materials on the proliferation of vascular smooth muscle cells
- Retinoblastoma Tumor Burden Control: Periocular m-TOR Inhibitor Rapamycin Decreases Tumor Burden in Advanced LHBETATAG Murine Retinoblastoma
- Effects of Mycophenolic Acid and Rapamycin on Toll-like Receptor Expression in Hypoxic Human Proximal Tubular Epithelial Cells
- The Impact of Iron Deficiency During Development on Mammalian Target of Rapamycin Signaling, Neuronal Structure, and Learning and Memory Behavior
- Mammalian Target of Rapamycin: A Bump in the Pathway to NF-κB Activation and ICAM-1 Expression in Endothelial Cells.
- Increased Frequency Of Regulatory T-Cells And Selection Of Highly Potent CD62L+ Cells During Treatment Of Human Lung Recipients With Rapamycin
- The IGF-1 receptor targeting antibody, CP-751,871, suppresses tumor-derived VEGF and synergizes with Rapamycin in models of childhood sarcoma
- Targeting mammalian target of Rapamycin (mTOR) signaling in the Han: SPRD rat, a model for polycystic kidney disease
- Chemical Genetic Dissection of TOR Signaling Through Identification and Characterization of Small Molecule Enhancers of Rapamycin
- Mammalian Target of Rapamycin Signaling and the Suprachiasmatic Circadian Clock
- Abstract# 3712: OXA-01, a novel potent mTORC1/TORC2 inhibitor displays improved anti-tumor activity in comparison to Rapamycin, an mTORC1 selective inhibitor
- inhibition of mammalian target of Rapamycin induces phenotypic reversion in three-dimensional cultures of malignant breast epithelial cells
- Rapamycin mediated inhibition of mTOR prevents postprandial activation of the unfolded protein response and upregulation of fatty acid synthase
- Distinct phosphatase requirements and GATA factor responses to nitrogen catabolite repression and Rapamycin treatment in S. cerevisiae
- Use of Rapamycin Reveals Evidence of the Physiological Roles of FKBP12 and FKBP12. 6 In Cardiac Excitation-Contraction Coupling
- e0520 Statin effects in stent thrombosis induced by Rapamycin releasing from drug-eluting stents through KrÜppel-Like Factor 2 overexpression
- Rapamycin enhanced in vitro and in vivo activity of dexamethasone against acute lymphoblastic leukemia and lymphoma preclincal models via inhibition of p70S6 …
- Human T Cell Rapamycin Resistance And Th1/Tc1 Polarization Augment Xenogeneic Graft-Versus-Host Disease
- Abstract# 4363: inhibition of mammalian target of Rapamycin (mTOR) in advanced pancreatic cancer-the results of two prospective phase II studies.
- In vitro enhancing oxidative phosphorylation by Rapamycin in proliferative CD8+ T cells during antigenic priming augments the generation of long-lived memory T cells …
- Comparasion of therapeutic effects of Chinese Rapamycin-eluting stent and imported paclitaxel-eluting stent in treatment of acute myocardial infarction
- Generation of tolerogenic human DC through Rapamycin conditioning and genetic modification with HLA-G.
- Prolonged Exposure of Myeloid Dendritic Cells To Rapamycin enhances LPS-induced IL-12p70 production, but does not promote Th1 responses (141.29)
- The mammalian target of Rapamycin mediates the angiogenic and chemotactic effects of leptin in human hepatic stellate cells.
- Calorie restriction and Rapamycin, but not exercise, inhibit MMTV-Wnt-1 mammary tumor growth in a mouse model of postmenopausal obesity
- Abstract# LB-135: Grapefruit juice significantly increases bioavailability of weekly Rapamycin (sirolimus)-evidence of safety and activity in a phase 1 study
- Mammalian Target of Rapamycin (mTOR)-mediated Effect on Disease Progression in Autosomal Dominant Polycystic Kidney Disease (ADPKD)
- Vitamin K_3 induces autophagy in HeLa cells through downregulating the mammalian target of Rapamycin (mTOR) pathway
- Pharmacodynamic (PD) study of pre-prostatectomy Rapamycin in men with advanced localized prostate cancer (PC): A DOD Prostate Cancer Clinical Trials …
- Effects of high-fat vs. low-fat diets on mammalian target of Rapamycin signaling and metabolic measures in spontaneously hypertensive rats
- Anti-liver fibrotic effect of Salvia miltiorthiza and Shugan-Huayu powder combining with or without Rapamycin in animal models.
- Rapidly Inducible Protein Modification Using Rapamycin-mediated Complementation Of Tobacco Etch Virus (TEV) Protease
- Modulatory Role of Mammalian Target of Rapamycin in Regulating Endothelial ICAM‐1 Expression and Lung PMN Recruitment
- Erratum: Mammalian target of Rapamycin activator RHEB is frequently overexpressed in human carcinomas and is critical and sufficient for skin epithelial …
- Rapamycin AND MYCOPHENOLIC ACID, BUT NOT CYCLOSPORIN A, IMPAIR HUMAN NK CELL CYTOLYTIC ACTIVITY DUE TO DIFFERENTIAL EFFECTS ON …
- 198 Modulation of CCR5 density with low doses of the transplant drug Rapamycin sensitizes Vicriviroc-resistant R5 HIV-1
- Rapamycin and IL-2 Prevents Lethal Acute Graft-Versus Host Disease by Expansion of Donor Type CD4+CD25+Foxp3+ Regulatory T Cells.
- Abstract# 4648: Rapamycin inhibits tube formation of lymphatic endothelial cells by targeting TORC1-mediated expression of Flt4
- Abstract LB-74: A high-throughput RNAi sensitization screen of Rapamycin identifies targets for rational drug combination strategies
- Abstract# 2770: Over-expression of the mammalian target of Rapamycin (mTOR): a novel biomarker for poor survival in resected early stage non-small cell lung cancer
- Abstract# 2014: ATP competitive inhibitors of the mammalian target of Rapamycin (mTOR): Design and synthesis of novel, highly selective pyrazolopyrimidines with …
- The Mammalian Target of Rapamycin (mTOR) Is a Novel Regulator of HMW-Hyaluronan-Mediated Pulmonary Endothelial Barrier Enhancement.
- COMBINED ADMINISTRATION OF A NOVEL MUTANT TGF-β1/FC AND Rapamycin MODULATES THE IMMUNE BALANCE BETWEEN TREG AND TH17 AND …
- CD28: FC AND Rapamycin CAN PREVENT TH17-MEDIATED ALLOGRAFT REJECTION IN MOUSE PANCREATIC ISLET TRANSPLANTATION MODEL: 700
- Androgen receptor antagonist bicalutamide sensitizes androgen-independent prostate cancer cells to mTOR inhibitor Rapamycin by regulating phosphorylation of …
- Abstract# 1735: Rapamycin inhibits hyperactivation of mTORC1 signaling in a novel xenograft model of tuberous sclerosis complex skin tumors
- ET-29. ONCOLYTIC VIRUS COMBINED WITH Rapamycin TARGETING BRAIN TUMOR-INITIATING CELLS
- … Multicenter phase I clinical trial of an insulin like growth factor (IGF‐R) inhibitor (IMC‐A12) in combination with a mammalian target of Rapamycin (mTOR) inhibitor (CCI …
- Mouse Oocytes Promote the Mechanistic Target of Rapamycin (Serine/Threonine Kinase, mTOR) Pathway in Cumulus Cells by Suppressing the Expression of DNA …
- … oral protein: time‐dependent concordance/discordance between muscle protein synthesis (MPS) and mammalian target of Rapamycin (mTOR)‐associated signaling
- Relationship between expression of mutant type glutathione S-transferase theta-1 gene and reactivity of Rapamycin in myelodysplastic syndrome
- Rapamycin CONDITIONED DENDRITIC CELLS FOR IN VITRO DIFFERENTIATION OF DONOR-SPECIFIC CD4+ CD25+ FOXP3+ REGULATORY T CELLS FOR …
- … DEVELOPMENT OF CD8+ CD44+ CD62L+ MEMORY T CELLS PROMOTE SPECIFIC TOLERANCE TO CARDIAC ALLOGRAFTS FOLLOWING Rapamycin …
- Abstract# 4050: Increased cytotoxicity with nifurtimox and Rapamycin combination therapy in neuroblastoma.
- The Effect of Insulin-like Growth Factor 1 (IGF-1) and Exercise on the Protein Expression of Mammalian Target of Rapamycin (mTOR) and Androgen Receptor (AR) in …
- Abstract# 3711: Superior cellular anti-tumor effects of a dual mTORC1/mTORC2 kinase inhibitor OXA-01 relative to the mTORC1 inhibitor Rapamycin
- Erratum 2: Testosterone induces cardiomyocyte hypertrophy through mammalian target of Rapamycin complex 1 pathway
- Erratum 2: Testosterone induces cardiomyocyte hypertrophy through mammalian target of Rapamycin complex 1 pathway (vol 202, pg 299, 2009)
- Abstract# 156: Is irinotecan and Rapamycin combination, targeting mTOR/HIF-1 alpha axis, a new effective therapy in high grade brain tumors?
- Intra-Nuclear Function for PP2A Phosphatase: Pph21/22 Are Required for Rapamycin-Induced GATA Factor Binding to the DAL5 Promoter in Yeast
- Activating transcription factor 4 negatively regulates the mammalian target of Rapamycin via Redd1 expression in response to 2-deoxyglucose
- Abstract# 5237: The combination of Rapamycin and bicalutamide induce apoptosis in prostate cancer cells by simultaneously inhibiting the mTORC1/eIF4 and AR …
- TORC1/2 inhibitors have more potent anti-leukemic efficacy and are less immunosuppressive than Rapamycin
- Abstract# 2824: The Src inhibitor AZD0530 enhances the anti-tumor effect of Rapamycin in hepatocellular carcinoma (HCC) cells
- Abstract LB-159: An orthotopic model of head and neck squamous carcinoma reveals that mTOR inhibition with Rapamycin halts lymph node metastasis
- Abstract# 3842: High expression of mTOR (mammalian target of Rapamycin) is associated with better outcome in non-small cell lung cancer
- Abstract# 1079: CD133 expression is affected by Rapamycin in cancer cells.
- Abstract# 2879: inhibition of mammalian target of Rapamycin as a therapeutic strategy in the management of bladder cancer
- Abstract# 3757: Antiproliferative effects of Rapamycin and doxorubicin combination on human Erbb2 overexpressing breast epithelial cell lines.
- Abstract# 2818: Growth inhibition of human breast cancer cells with an iron chelator and a dual phosphatidylinositol 3-kinase/mammalian target of Rapamycin inhibitor
- Abstract# 2302: NVP-BEZ235 a dual inhibitor of phosphatidylinositol 3-Kinase (PI3 Kinase) and mammalian target of Rapamycin (mTOR) potently enhances the effects …
- Liposomal KRN7000 (RGI-2001) Synergizes with Low-Dose Rapamycin in Preventing GvHD by promoting expansion of naturally-Occurring CD4+FOXP3+ …
- Abstract P3-14-17: Trastuzumab (H) and Rapamycin (R) for Treatment of HER-2 Overexpressing Metastatic Breast Cancer (BC) with Prior Disease Progression on H …
- … : HQO-0601, an amide-containing 3, 4-dihydroquinolinone derivative, against human hematologic malignancies through inhibition of mammalian target of Rapamycin …
- Rapamycin slows aging in mice
- Fighting neurodegeneration with Rapamycin: mechanistic insights
- Target of Rapamycin (TOR) in nutrient signaling and growth control
- Rapamycin and glucose-target of Rapamycin (TOR) protein signaling in plants
- Rapamycin passes the torch: a new generation of mTOR inhibitors
- Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity
- Autophagy activation by Rapamycin reduces severity of experimental osteoarthritis
- Protein translocation as a tool: The current Rapamycin story
- Relieving autophagy and 4EBP1 from Rapamycin resistance
- Chronic inhibition of mammalian target of Rapamycin by Rapamycin modulates cognitive and non-cognitive components of behavior throughout lifespan in mice
- Paradoxical aspects of Rapamycin immunobiology in transplantation
- Rapamycin and mTOR: a serendipitous discovery and implications for breast cancer
- Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice
- TOR signaling and Rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO
- Rapamycin for treating Tuberous sclerosis and Autism spectrum disorders
- The mammalian target of Rapamycin regulates cholesterol biosynthetic gene expression and exhibits a Rapamycin-resistant transcriptional profile
- A photocleavable Rapamycin conjugate for spatiotemporal control of small GTPase activity
- Target of Rapamycin signaling regulates metabolism, growth, and life span in Arabidopsis
- Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice
- Rapamycin reverses impaired social interaction in mouse models of tuberous sclerosis complex
- Rapamycin and other longevity‐promoting compounds enhance the generation of mouse induced pluripotent stem cells
- mTOR and Rapamycin in the kidney: signaling and therapeutic implications beyond immunosuppression
- Inducing autophagy by Rapamycin before, but not after, the formation of plaques and tangles ameliorates cognitive deficits
- … enhances the anti-tumor activity of the mTOR inhibitor Rapamycin in multiple breast cancer cell lines mainly by suppressing Rapamycin-induced AKT signaling
- Common toxicities of mammalian target of Rapamycin inhibitors
- Topical Rapamycin therapy to alleviate the cutaneous manifestations of tuberous sclerosis complex
- Rapamycin treatment augments motor neuron degeneration in SOD1G93A mouse model of amyotrophic lateral sclerosis
- Activating mutations of TOR (target of Rapamycin)
- Rapamycin reverses cellular phenotypes and enhances mutant protein clearance in Hutchinson-Gilford progeria syndrome cells
- Rapamycin/IL-2 combination therapy in patients with type 1 diabetes augments Tregs yet transiently impairs β-cell function
- Mammalian target of Rapamycin: a signaling kinase for every aspect of cellular life
- Mammalian target of Rapamycin: a central node of complex signaling cascades
- Induction of tolerance to factor VIII by transient co‐administration with Rapamycin
- Once again on Rapamycin-induced insulin resistance and longevity: despite of or owing to
- Haploinsufficiency of target of Rapamycin attenuates cardiomyopathies in adult zebrafish
- Stability of human Rapamycin-expanded CD4+ CD25+ T regulatory cells
- Autophagy and cardiovascular aging: lesson learned from Rapamycin
- Rapamycin extends lifespan and delays tumorigenesis in heterozygous p53+/− mice
- A pulse Rapamycin therapy for infantile spasms and associated cognitive decline
- Hyperplexing: a method for higher-order multiplexed quantitative proteomics provides a map of the dynamic response to Rapamycin in yeast
- Rapamycin protects against myocardial ischemia–reperfusion injury through JAK2–STAT3 signaling pathway
- Mammalian target of Rapamycin and the kidney. I. The signaling pathway
- The ketogenic diet inhibits the mammalian target of Rapamycin (mTOR) pathway
- Preventive and therapeutic effects of Rapamycin, a mammalian target of Rapamycin inhibitor, on food allergy in mice
- Shedding new light on neurodegenerative diseases through the mammalian target of Rapamycin
- Lifelong Rapamycin administration ameliorates age‐dependent cognitive deficits by reducing IL‐1β and enhancing NMDA signaling
- Mammalian target of Rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth
- Mammalian target of Rapamycin signaling in diabetic cardiovascular disease
- Rapamycin promotes autophagy and reduces neural tissue damage and locomotor impairment after spinal cord injury in mice
- Folate-conjugated Rapamycin slows progression of polycystic kidney disease
- Mammalian target of Rapamycin (mTOR) signaling network in skeletal myogenesis
- Rapamycin suppresses mossy fiber sprouting but not seizure frequency in a mouse model of temporal lobe epilepsy
- Chronic mTOR inhibition by Rapamycin induces muscle insulin resistance despite weight loss in rats
- Wound healing complications and the use of mammalian target of Rapamycin inhibitors in kidney transplantation: a critical review of the literature
- Rapamycin increases oxidative stress response gene expression in adult stem cells
- inhibition of mammalian target of Rapamycin reduces epileptogenesis and blood–brain barrier leakage but not microglia activation
- Rapamycin As an Antiaging Therapeutic?: Targeting Mammalian Target of Rapamycin to Treat Hutchinson–Gilford Progeria and Neurodegenerative Diseases
- Successful treatment of angiofibromata of tuberous sclerosis complex with Rapamycin
- Rapamycin protects against middle cerebral artery occlusion induced focal cerebral ischemia in rats
- Rapamycin Causes Upregulation of Autophagy and Impairs Islets Function Both In Vitro and In Vivo
- Therapeutic role of mammalian target of Rapamycin (mTOR) inhibition in preventing epileptogenesis
- Monitoring autophagic flux by an improved tandem fluorescent-tagged LC3 (mTagRFP-mWasabi-LC3) reveals that high-dose Rapamycin impairs autophagic flux in …
- Prevention of age-related macular degeneration–like retinopathy by Rapamycin in Rats
- Mammalian target of Rapamycin: a valid therapeutic target through the autophagy pathway for Alzheimer’s disease?
- The interaction between early life epilepsy and autistic-like behavioral consequences: a role for the mammalian target of Rapamycin (mTOR) pathway
- Current and future directions in mammalian target of Rapamycin inhibitors development
- Gli inhibitor GANT61 causes apoptosis in myeloid leukemia cells and acts in synergy with Rapamycin
- Target of Rapamycin regulates development and ribosomal RNA expression through kinase domain in Arabidopsis
- Mammalian target of Rapamycin complex 1 activation is required for the stimulation of human skeletal muscle protein synthesis by essential amino acids
- The PI3K/Akt/mTOR pathway is activated in murine lupus nephritis and downregulated by Rapamycin
- inhibition of mammalian target of Rapamycin augments lipopolysaccharide-induced lung injury and apoptosis
- New nanoformulation of Rapamycin Rapatar extends lifespan in homozygous p53−/− mice by delaying carcinogenesis
- Combinatorial effects of lapatinib and Rapamycin in triple-negative breast cancer cells
- Phase II study of the mammalian target of Rapamycin inhibitor ridaforolimus in patients with advanced bone and soft tissue sarcomas
- Impaired autophagy in neurons after disinhibition of mammalian target of Rapamycin and its contribution to epileptogenesis
- Rapamycin delays disease onset and prevents PrP plaque deposition in a mouse model of Gerstmann–Sträussler–Scheinker disease
- Identification of Akt-independent regulation of hepatic lipogenesis by mammalian target of Rapamycin (mTOR) complex 2
- Rapamycin reverses elevated mTORC1 signaling in lamin A/C–deficient mice, rescues cardiac and skeletal muscle function, and extends survival
- Retinoic acid and Rapamycin differentially affect and synergistically promote the ex vivo expansion of natural human T regulatory cells
- Rapamycin increases rDNA stability by enhancing association of Sir2 with rDNA in Saccharomyces cerevisiae
- Review of cytomegalovirus infection findings with mammalian target of Rapamycin inhibitor-based immunosuppressive therapy in de novo renal transplant recipients
- Low‐Dose Rapamycin Treatment Increases the Ability of Human Regulatory T Cells to Inhibit Transplant Arteriosclerosis In Vivo
- Stable isotope-labelling analysis of the impact of inhibition of the mammalian target of Rapamycin on protein synthesis
- Managing stomatitis in patients treated with Mammalian target of Rapamycin inhibitors.
- Rapamycin reverses hypertrophic cardiomyopathy in a mouse model of LEOPARD syndrome–associated PTPN11 mutation
- Rapamycin blocks production of KSHV/HHV8: insights into the anti-tumor activity of an immunosuppressant drug
- inhibition of mechanistic target of Rapamycin promotes dendritic cell activation and enhances therapeutic autologous vaccination in mice
- Therapeutic value of prenatal Rapamycin treatment in a mouse brain model of tuberous sclerosis complex
- Selective pharmacogenetic inhibition of mammalian target of Rapamycin complex I (mTORC1) blocks long-term synaptic plasticity and memory storage
- Rapamycin slows aging in mice
- Amino acids activate mammalian target of Rapamycin complex 2 (mTORC2) via PI3K/Akt signaling
- Suppression of replicative senescence by Rapamycin in rodent embryonic cells
- inhibition of the mammalian target of Rapamycin blocks epilepsy progression in NS‐Pten conditional knockout mice
- The mTOR inhibitor Rapamycin suppresses DNA double-strand break repair
- Autophagy stimulation by Rapamycin suppresses lung inflammation and infection by Burkholderia cenocepacia in a model of cystic fibrosis
- Rapamycin for treatment of type I autosomal dominant polycystic kidney disease (RAPYD-study): a randomized, controlled study
- Differing effects of Rapamycin or calcineurin inhibitor on T‐regulatory cells in pediatric liver and kidney transplant recipients
- Neuronal and glia abnormalities in Tsc1-deficient forebrain and partial rescue by Rapamycin
- Post-treatment with Rapamycin does not prevent epileptogenesis in the amygdala stimulation model of temporal lobe epilepsy
- Mammalian target of Rapamycin and the kidney. II. Pathophysiology and therapeutic implications
- Rapamycin inhibits proliferation of hemangioma endothelial cells by reducing HIF-1-dependent expression of VEGF
- Optimization of Rapamycin-loaded acetalated dextran microparticles for immunosuppression
- Rapamycin induces glucose intolerance in mice by reducing islet mass, insulin content, and insulin sensitivity
- Mammalian target of Rapamycin regulates neutrophil extracellular trap formation via induction of hypoxia-inducible factor 1 α
- Stress-responsive sestrins link p53 with redox regulation and mammalian target of Rapamycin signaling
- Rapamycin ameliorates age-dependent obesity associated with increased mTOR signaling in hypothalamic POMC neurons
- Oral Rapamycin in the treatment of patients with hamartoma syndromes and PTEN mutation
- Oral adverse events associated with tyrosine kinase and mammalian target of Rapamycin inhibitors in renal cell carcinoma: a structured literature review
- Efficacy and safety of sorafenib in combination with mammalian target of Rapamycin inhibitors for recurrent hepatocellular carcinoma after liver transplantation
- Involvement of the mammalian target of Rapamycin signaling in the antidepressant-like effect of group II metabotropic glutamate receptor antagonists
- N‐acetylcysteine reduces disease activity by blocking mammalian target of Rapamycin in T cells from systemic lupus erythematosus patients: A randomized, double …
- … lactate dehydrogenase predicts for overall survival benefit in patients with metastatic renal cell carcinoma treated with inhibition of mammalian target of Rapamycin
- Antitumor activity of Triolimus: a novel multidrug-loaded micelle containing Paclitaxel, Rapamycin, and 17-AAG
- Rapamycin-induced glucose intolerance: hunger or starvation diabetes
- Induction of biogenic magnetization and redox control by a component of the target of Rapamycin complex 1 signaling pathway
- Rapamycin resistance is linked to defective regulation of Skp2
- Rapamycin ameliorates kidney fibrosis by inhibiting the activation of mTOR signaling in interstitial macrophages and myofibroblasts
- Roles of the mammalian target of Rapamycin, mTOR, in controlling ribosome biogenesis and protein synthesis
- The mTOR inhibitor Rapamycin has limited acute anticonvulsant effects in mice
- Multiple roles for mammalian target of Rapamycin signaling in both glutamatergic and GABAergic synaptic transmission
- Rapamycin suppresses self-renewal and vasculogenic potential of stem cells isolated from infantile hemangioma
- Rapamycin-induced enhancement of vaccine efficacy in mice
- Regulating mammalian target of Rapamycin to tune vaccination-induced CD8+ T cell responses for tumor immunity
- Biosynthesis of the immunosuppressants FK506, FK520, and Rapamycin involves a previously undescribed family of enzymes acting on chorismate
- A comprehensive review of everolimus clinical reports: a new mammalian target of Rapamycin inhibitor
- Selective activation of Akt1 by mammalian target of Rapamycin complex 2 regulates cancer cell migration, invasion, and metastasis
- Rab5 proteins regulate activation and localization of target of Rapamycin complex 1
- Mutations in the Arabidopsis homolog of LST8/GβL, a partner of the target of Rapamycin kinase, impair plant growth, flowering, and metabolic adaptation to long days
- Mammalian target of Rapamycin (mTOR) inhibition: potential for antiseizure, antiepileptogenic, and epileptostatic therapy
- Expanding human T regulatory cells with the mTOR-inhibitor Rapamycin
- Effects of Rapamycin and TOR on aging and memory: implications for Alzheimer’s disease
- Naturally secreted amyloid-β increases mammalian target of Rapamycin (mTOR) activity via a PRAS40-mediated mechanism
- Phospholipase D mediates nutrient input to mammalian target of Rapamycin complex 1 (mTORC1)
- Rapamycin activates autophagy in Hutchinson-Gilford progeria syndrome: implications for normal aging and age-dependent neurodegenerative disorders
- Plasma membrane recruitment and activation of the AGC kinase Ypk1 is mediated by target of Rapamycin complex 2 (TORC2) and its effector proteins Slm1 and Slm2
- Rapamycin induces Bad phosphorylation in association with its resistance to human lung cancer cells
- Mycobacterial induction of autophagy varies by species and occurs independently of mammalian target of Rapamycin inhibition
- Third target of Rapamycin complex negatively regulates development of quiescence in Trypanosoma brucei
- Rapamycin toxicity in MIN6 cells and rat and human islets is mediated by the inhibition of mTOR complex 2 (mTORC2)
- Rapamycin attenuates airway hyperreactivity, goblet cells, and IgE in experimental allergic asthma
- mTOR inhibition with Rapamycin causes impaired insulin signalling and glucose uptake in human subcutaneous and omental adipocytes
- Progeria, Rapamycin and normal aging: recent breakthrough
- Resveratrol inhibits inflammatory responses via the mammalian target of Rapamycin signaling pathway in cultured LPS-stimulated microglial cells
- High-dose Rapamycin induces apoptosis in human cancer cells by dissociating mTOR complex 1 and suppressing phosphorylation of 4E-BP1
- Systemic inhibition of the mammalian target of Rapamycin (mTOR) pathway reduces neuropathic pain in mice
- The differential effects of prenatal and/or postnatal Rapamycin on neurodevelopmental defects and cognition in a neuroglial mouse model of tuberous sclerosis …
- Induction of autophagy by palmitic acid via protein kinase C-mediated signaling pathway independent of mTOR (mammalian target of Rapamycin)
- Nucleolar disruption in dopaminergic neurons leads to oxidative damage and parkinsonism through repression of mammalian target of Rapamycin signaling
- Rapamycin and IL-2 reduce lethal acute graft-versus-host disease associated with increased expansion of donor type CD4+CD25+Foxp3+ regulatory T cells
- The mTOR kinase inhibitor Rapamycin decreases iNOS mRNA stability in astrocytes
- Insulin-like peptides and the target of Rapamycin pathway coordinately regulate blood digestion and egg maturation in the mosquito Aedes aegypti
- Heightened uterine mammalian target of Rapamycin complex 1 (mTORC1) signaling provokes preterm birth in mice
- inhibition of the mammalian target of Rapamycin pathway by Rapamycin blocks cocaine-induced locomotor sensitization
- Tolerance induction by exosomes from immature dendritic cells and Rapamycin in a mouse cardiac allograft model
- Rapamycin is a potent inhibitor of skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate
- Characterization of the metabolic phenotype of Rapamycin-treated CD8+ T cells with augmented ability to generate long-lasting memory cells
- Light regulation of protein dimerization and kinase activity in living cells using photocaged Rapamycin and engineered FKBP
- Mammalian target of Rapamycin signaling is a key regulator of the transit-amplifying progenitor pool in the adult and aging forebrain
- Metformin promotes progesterone receptor expression via inhibition of mammalian target of Rapamycin (mTOR) in endometrial cancer cells
- A critical role for non-coding RNA GAS5 in growth arrest and Rapamycin inhibition in human T-lymphocytes
- Structure-activity analysis of niclosamide reveals potential role for cytoplasmic pH in control of mammalian target of Rapamycin complex 1 (mTORC1) signaling
- Dramatic improvement of facial angiofibromas in tuberous sclerosis with topical Rapamycin: optimizing a treatment protocol
- Mapping the spatio-temporal pattern of the mammalian target of Rapamycin (mTOR) activation in temporal lobe epilepsy
- Rapamycin inhibits lymphatic endothelial cell tube formation by downregulating vascular endothelial growth factor receptor 3 protein expression
- Anticancer peptidylarginine deiminase (PAD) inhibitors regulate the autophagy flux and the mammalian target of Rapamycin complex 1 activity
- Rapamycin exerts antifungal activity in vitro and in vivo against Mucor circinelloides via FKBP12-dependent inhibition of Tor
- Mammalian target of Rapamycin complex 1 (mTORC1) and 2 (mTORC2) control the dendritic arbor morphology of hippocampal neurons
- Mammalian target of Rapamycin complex 2 (mTORC2) negatively regulates Toll-like receptor 4-mediated inflammatory response via FoxO1
- Proteomic identification of novel targets regulated by the mammalian target of Rapamycin pathway during oligodendrocyte differentiation
- Phosphoproteomic profiling of in vivo signaling in liver by the mammalian target of Rapamycin complex 1 (mTORC1)
- The influence of co-solvents on the stability and bioavailability of Rapamycin formulated in self-microemulsifying drug delivery systems
- Altered APP processing in insulin-resistant conditions is mediated by autophagosome accumulation via the inhibition of mammalian target of Rapamycin pathway
- Rapamycin has a biphasic effect on insulin sensitivity in C2C12 myotubes due to sequential disruption of mTORC1 and mTORC2
- Rapamycin attenuates aggressive behavior in a rat model of pilocarpine-induced epilepsy
- inhibition of mTOR by Rapamycin in the amygdala or hippocampus impairs formation and reconsolidation of inhibitory avoidance memory
- Convergence of the mammalian target of Rapamycin complex 1-and glycogen synthase kinase 3-β–signaling pathways regulates the innate inflammatory response
- Rapamycin for Treatment of Epilepsy: Antiseizure, Antiepileptogenic, Both, or Neither? Rapamycin for Treatment of Epilepsy
- Rapamycin reduces clinical signs and neuropathic pain in a chronic model of experimental autoimmune encephalomyelitis
- Stimulation of autophagy by Rapamycin protects neurons from remote degeneration after acute focal brain damage
- The physiology and pathophysiology of Rapamycin resistance: implications for cancer
- Combination therapy targeting Akt and mammalian target of Rapamycin improves functional outcome after controlled cortical impact in mice
- Rapamycin paradox resolved
- Combining mTOR inhibitors with Rapamycin-resistant T cells: a two-pronged approach to tumor elimination
- Circadian regulation of mammalian target of Rapamycin signaling in the mouse suprachiasmatic nucleus
- Mammalian Target of Rapamycin (mTOR) Inhibitors
- Dietary restriction but not Rapamycin extends disease onset and survival of the H46R/H48Q mouse model of ALS
- Rapamycin with antiretroviral therapy in AIDS-associated Kaposi sarcoma: an AIDS Malignancy Consortium study
- Rapamycin reduces reactive oxygen species in cultured human corneal endothelial cells
- mTOR-dependent regulation of PHLPP expression controls the Rapamycin sensitivity in cancer cells
- Mammalian target of Rapamycin integrates diverse inputs to guide the outcome of antigen recognition in T cells
- Targeting the mammalian target of Rapamycin (mTOR) in cancer therapy: lessons from past and future perspectives
- … mechanism of atorvastatin to protect mesenchymal stem cells from hypoxia and serum deprivation via AMP-activated protein kinase/mammalian target of Rapamycin …
- Consolidation and reconsolidation of contextual fear memory requires mammalian target of Rapamycin-dependent translation in the dorsal hippocampus
- Effects of cyclosporine, tacrolimus and Rapamycin on renal calcium transport and vitamin D metabolism
- AMP-dependent kinase/mammalian target of Rapamycin complex 1 signaling in T-cell acute lymphoblastic leukemia: therapeutic implications
- Ghrelin contributes to derangements of glucose metabolism induced by Rapamycin in mice
- TORC1 of fission yeast is Rapamycin‐sensitive
- Target-of-Rapamycin complex 1 (Torc1) signaling modulates cilia size and function through protein synthesis regulation
- Therapy of sclerodermatous chronic graft-versus-host disease with mammalian target of Rapamycin inhibitors
- The tuberous sclerosis complex–mammalian target of Rapamycin pathway maintains the quiescence and survival of naive T cells
- Low dose Rapamycin exacerbates autoimmune experimental uveitis
- Rapamycin impairs proliferation of transplanted islet β cells
- The role of mammalian target of Rapamycin (mTOR) in the regulation of pancreatic β-cell mass: implications in the development of type-2 diabetes
- Observations on enhanced port wine stain blanching induced by combined pulsed dye laser and Rapamycin administration
- Kinome-wide selectivity profiling of ATP-competitive mammalian target of Rapamycin (mTOR) inhibitors and characterization of their binding kinetics
- Adiponectin induces vascular smooth muscle cell differentiation via repression of mammalian target of Rapamycin complex 1 and FoxO4
- Activation of PI3K/AKT and MAPK pathway through a PDGFRβ-dependent feedback loop is involved in Rapamycin resistance in hepatocellular carcinoma
- Cannabinoid receptor agonists modulate oligodendrocyte differentiation by activating PI3K/Akt and the mammalian target of Rapamycin (mTOR) pathways
- Redox regulates mammalian target of Rapamycin complex 1 (mTORC1) activity by modulating the TSC1/TSC2-Rheb GTPase pathway
- Campylobacter jejuni induces colitis through activation of mammalian target of Rapamycin signaling
- Mechanistic target of Rapamycin inhibitors in solid organ transplantation: from benchside to clinical use
- Dihydroartemisinin ameliorates inflammatory disease by its reciprocal effects on Th and regulatory T cell function via modulating the mammalian target of Rapamycin …
- Differing effects of Rapamycin and mTOR kinase inhibitors on protein synthesis
- Coupling nutrient sensing to metabolic homoeostasis: the role of the mammalian target of Rapamycin complex 1 pathway
- Impairment of object recognition memory by Rapamycin inhibition of mTOR in the amygdala or hippocampus around the time of learning or reactivation
- Discovery of a potent, selective, and orally available class I phosphatidylinositol 3-kinase (PI3K)/mammalian target of Rapamycin (mTOR) kinase inhibitor (GDC-0980) …
- Phosphatidic acid activates mammalian target of Rapamycin complex 1 (mTORC1) kinase by displacing FK506 binding protein 38 (FKBP38) and exerting an …
- A topical combination of Rapamycin and tacrolimus for the treatment of angiofibroma due to tuberous sclerosis complex (TSC): a pilot study of nine Japanese patients …
- Assessing the effectiveness of Rapamycin on angiomyolipoma in tuberous sclerosis: a two years trial
- Resveratrol inhibits cancer cell metabolism by down regulating pyruvate kinase M2 via inhibition of mammalian target of Rapamycin
- Rapamycin partially mimics the anticancer effects of calorie restriction in a murine model of pancreatic cancer
- PDGF receptor alpha is an alternative mediator of Rapamycin-induced Akt activation: implications for combination targeted therapy of synovial sarcoma
- The emerging role of mammalian target of Rapamycin inhibitors in the treatment of sarcomas
- Differential effects of Rapamycin on rods and cones during light-induced stress in albino mice
- Evaluation of Rapamycin-induced cell death
- Rapid cytoplasmic turnover of yeast ribosomes in response to Rapamycin inhibition of TOR
- … mammalian target of Rapamycin (mTOR) inhibitor activates extracellular signal-regulated kinase (ERK) in multiple myeloma cells via a target of Rapamycin …
- Rapamycin attenuates the expression of cocaine‐induced place preference and behavioral sensitization
- The mammalian target of Rapamycin inhibitor everolimus (RAD001) in early breast cancer: results of a pre-operative study
- L-tryptophan-mediated enhancement of susceptibility to nonalcoholic fatty liver disease is dependent on the mammalian target of Rapamycin
- Starvation and Rapamycin differentially regulate host cell lysosome exocytosis and invasion by Trypanosoma cruzi metacyclic forms
- Paradoxical effects of Rapamycin on experimental house dust mite-induced asthma
- Magnetic nanoparticles and Rapamycin encapsulated into polymeric nanocarriers
- Rapamycin inhibits osteolysis and improves survival in a model of experimental bone metastases
- Rapamycin synergizes cisplatin sensitivity in basal-like breast cancer cells through up-regulation of p73
- Rapamycin inhibits transforming growth factor β‐induced peritoneal angiogenesis by blocking the secondary hypoxic response
- Calorie restriction and Rapamycin inhibit MMTV-Wnt-1 mammary tumor growth in a mouse model of postmenopausal obesity
- Facial angiofibromas treated with topical Rapamycin: an excellent choice with fast response
- Rapamycin blocks hepatoblastoma growth in vitro and in vivo implicating new treatment options in high-risk patients
- Regulatory T cells require mammalian target of Rapamycin signaling to maintain both homeostasis and alloantigen-driven proliferation in lymphocyte-replete mice
- Spinal cord NMDA receptor-mediated activation of mammalian target of Rapamycin is required for the development and maintenance of bone cancer-induced pain …
- SIRT1 is required for the effects of Rapamycin on high glucose-inducing mesangial cells senescence
- The Akt/mammalian target of Rapamycin pathway is activated and associated with adverse prognosis in soft tissue leiomyosarcomas
- inhibition of Rapamycin-induced autophagy causes necrotic cell death associated with Bax/Bad mitochondrial translocation
- Emerging roles for mammalian target of Rapamycin inhibitors in the treatment of solid tumors and hematological malignancies
- An increase in basal BDNF provokes hyperactivation of the Akt-mammalian target of Rapamycin pathway and deregulation of local dendritic translation in a mouse …
- Novel synergistic antitumor effects of Rapamycin with bortezomib on hepatocellular carcinoma cells and orthotopic tumor model
- Mammalian target of Rapamycin regulates isoliquiritigenin-induced autophagic and apoptotic cell death in adenoid cystic carcinoma cells
- The mechanism of mTOR (mammalian target of Rapamycin) in a mouse model of polycystic ovary syndrome (PCOS)
- Discovery and optimization of a series of benzothiazole phosphoinositide 3-kinase (PI3K)/mammalian target of Rapamycin (mTOR) dual inhibitors
- Mammalian target of Rapamycin signaling in the podocyte
- Transcriptional regulation of gene expression during osmotic stress responses by the mammalian target of Rapamycin
- Mao-B elevation decreases parkin’s ability to efficiently clear damaged mitochondria: protective effects of Rapamycin
- Immunoregulatory properties of Rapamycin-conditioned monocyte-derived dendritic cells and their role in transplantation
- Novel feedback inhibition of surface antigen synthesis by mammalian target of Rapamycin (mTOR) signal and its implication for hepatitis B virus tumorigenesis and …
- A Hexane Fraction of Guava Leaves (Psidium guajava L.) Induces Anticancer Activity by Suppressing AKT/Mammalian Target of Rapamycin/Ribosomal p70 S6 …
- Clinical activity of mammalian target of Rapamycin inhibitors in solid tumors
- A novel application of topical Rapamycin formulation, an inhibitor of mTOR, for patients with hypomelanotic macules in tuberous sclerosis complex
- Targeting notch pathway enhances Rapamycin antitumor activity in pancreas cancers through PTEN phosphorylation
- Rapamycin ameliorates dystrophic phenotype in mdx mouse skeletal muscle
- Mammalian target of Rapamycin expression in poorly differentiated endocrine carcinoma: clinical and therapeutic future challenges
- Clinical and histopathologic characteristics of rash in cancer patients treated with mammalian target of Rapamycin inhibitors
- Grape polyphenols inhibit Akt/mammalian target of Rapamycin signaling and potentiate the effects of gefitinib in breast cancer
- Rapamycin increases the yield and effector function of human γδ T cells stimulated in vitro
- Rapamycin combined with TGF-β converts human invariant NKT cells into suppressive Foxp3+ regulatory cells
- Effect of dietary choline on growth, intestinal enzyme activities and relative expressions of target of Rapamycin and eIF4E-binding protein2 gene in muscle …
- Cancer cell survival following DNA damage-mediated premature senescence is regulated by mammalian target of Rapamycin (mTOR)-dependent inhibition of …
- Role of mammalian target of Rapamycin in hypoxic or ischemic brain injury: potential neuroprotection and limitations
- Spinal phosphinositide 3-Kinase–Akt–Mammalian target of Rapamycin signaling cascades in inflammation-induced hyperalgesia
- Enteric-delivered Rapamycin enhances resistance of aged mice to pneumococcal pneumonia through reduced cellular senescence
- Mechanistic or mammalian target of Rapamycin (mTOR) may determine robustness in young male mice at the cost of accelerated aging
- Intermittent supplementation with Rapamycin as a dietary restriction mimetic
- Modularity and hormone sensitivity of the Drosophila melanogaster insulin receptor/target of Rapamycin interaction proteome
- The histone H3 lysine 56 acetylation pathway is regulated by target of Rapamycin (TOR) signaling and functions directly in ribosomal RNA biogenesis
- TOR: target of Rapamycin
- Ksp1 kinase regulates autophagy via the target of Rapamycin complex 1 (TORC1) pathway
- Multiple site acetylation of Rictor stimulates mammalian target of Rapamycin complex 2 (mTORC2)-dependent phosphorylation of Akt protein
- Clinical outcomes in kidney transplant recipients receiving long‐term therapy with inhibitors of the mammalian target of Rapamycin
- Rapamycin preconditioning attenuates transient focal cerebral ischemia/reperfusion injury in mice
- … of 32-kDa (DARPP-32)-dependent activation of extracellular signal-regulated kinase (ERK) and mammalian target of Rapamycin complex 1 (mTORC1) …
- Mammalian target of Rapamycin and head and neck squamous cell carcinoma
- Rapamycin-insensitive mTORC1 activity controls eIF4E: 4E-BP1 binding
- Mammalian target of Rapamycin is a therapeutic target for murine ovarian endometrioid adenocarcinomas with dysregulated Wnt/β-catenin and PTEN
- Rapamycin suppresses axon sprouting by somatostatin interneurons in a mouse model of temporal lobe epilepsy
- Targeting the phosphatidylinositol 3-kinase/Akt/mammalian target of Rapamycin signaling network in cancer stem cells
- Resistin promotes cardiac hypertrophy via the AMP-activated protein kinase/mammalian target of Rapamycin (AMPK/mTOR) and c-Jun N-terminal kinase …
- Mechanistic mammalian target of Rapamycin (mTOR) cell signaling: effects of select nutrients and secreted phosphoprotein 1 on development of mammalian …
- The mTOR (mammalian target of Rapamycin) kinase maintains integrity of mTOR complex 2
- Rapamycin-mediated mTOR inhibition attenuates survivin and sensitizes glioblastoma cells to radiation therapy
- Creating diverse target-binding surfaces on FKBP12: synthesis and evaluation of a Rapamycin analogue library
- Rapamycin has paradoxical effects on S6 phosphorylation in rats with and without seizures
- A retrospective review of oral low-dose sirolimus (Rapamycin) for the treatment of active uveitis
- Elimination of proliferating cells unmasks the shift from senescence to quiescence caused by Rapamycin
- Drosophila insulin and target of Rapamycin (TOR) pathways regulate GSK3 beta activity to control Myc stability and determine Myc expression in vivo
- Rapamycin treatment inhibits CHO cell death in a serum‐free suspension culture by autophagy induction
- Mammalian target of Rapamycin (mTOR) inhibitors slow skin carcinogenesis, but impair wound healing
- Rapamycin Reverses Splenomegaly and Inhibits Tumor Development in a Transgenic Model of Epstein-Barr Virus–Related Burkitt’s Lymphoma
- A combined approach of classical mutagenesis and rational metabolic engineering improves Rapamycin biosynthesis and provides insights into methylmalonyl-CoA …
- The risk of skin rash and stomatitis with the mammalian target of Rapamycin inhibitor temsirolimus: a systematic review of the literature and meta-analysis
- Rapamycin reduces oxidative stress in frataxin-deficient yeast cells
- Advantage of Rapamycin over mycophenolate mofetil when used with tacrolimus for simultaneous pancreas kidney transplants: randomized, single‐center trial at 10 …
- Phosphorylation of Raptor by p38β participates in arsenite-induced mammalian target of Rapamycin complex 1 (mTORC1) activation
- Synergistic activity of Rapamycin and dexamethasone in vitro and in vivo in acute lymphoblastic leukemia via cell-cycle arrest and apoptosis
- … and a signaling core formed by bifunctional Akt, extracellular signal-regulated kinase (ERK) 1/2, and mammalian target of Rapamycin complex 1 (mTORC1) …
- LST8 regulates cell growth via target-of-Rapamycin complex 2 (TORC2)
- The mammalian target of Rapamycin pathway is widely activated without PTEN deletion in renal cell carcinoma metastases
- Rapamycin induces p53-independent apoptosis through the mitochondrial pathway in non-small cell lung cancer cells
- Evaluation of sphingolipid metabolism in renal cortex of rats with streptozotocin-induced diabetes and the effects of Rapamycin
- Dissecting mammalian target of Rapamycin to promote longevity
- Rapamycin treatment augments both protein ubiquitination and Akt activation in pressure-overloaded rat myocardium
- Impact of Rapamycin on peritoneal fibrosis and transport function
- Predictive biomarkers for the activity of mammalian target of Rapamycin (mTOR) inhibitors
- Rapamycin‐Induced Hypophosphatemia and Insulin Resistance Are Associated With mTORC2 Activation and Klotho Expression
- Phospshoinositide 3-kinase (PI3K)/mammalian target of Rapamycin (mTOR) dual inhibitors: discovery and structure–activity relationships of a series of quinoline and …
- Emergence of the phosphoinositide 3-kinase-Akt-mammalian target of Rapamycin axis in transforming growth factor-β-induced epithelial-mesenchymal transition
- Activation of mammalian target of Rapamycin pathway confers adverse outcome in nonsmall cell lung carcinoma
- Dual inhibition of phosphatidylinositol 3‐kinase/Akt and mammalian target of Rapamycin signaling in human nonsmall cell lung cancer cells by a dietary flavonoid …
- S6 kinase 1 is required for Rapamycin-sensitive liver proliferation after mouse hepatectomy
- Metabolic regulation, mitochondria and the life-prolonging effect of Rapamycin: a mini-review
- Induction of melanogenesis by Rapamycin in human MNT-1 melanoma cells
- Calcineurin inhibitor sparing regimens using m‐target of Rapamycin inhibitors: an opportunity to improve cardiovascular risk following kidney transplantation?
- The mammalian target of Rapamycin pathway as a therapeutic target in multiple myeloma
- … and its associated cell death by “sphingolipid rheostat”: reciprocal role of ceramide and sphingosine 1-phosphate in the mammalian target of Rapamycin …
- Rapamycin sensitive mTOR activation mediates nerve growth factor (NGF) induced cell migration and pro-survival effects against hydrogen peroxide in retinal pigment …
- Regulation of the glutamate transporter EAAT3 by mammalian target of Rapamycin mTOR
- Ubiquitin-specific peptidase 9, X-linked (USP9X) modulates activity of mammalian target of Rapamycin (mTOR)
- The mammalian target of Rapamycin inhibitor RAD001 (everolimus) synergizes with chemotherapeutic agents, ionizing radiation and proteasome inhibitors in …
- Stromal liver kinase B1 [STK11] signaling loss induces oviductal adenomas and endometrial cancer by activating mammalian Target of Rapamycin Complex …
- NVP-BEZ235 and NVP-BGT226, dual phosphatidylinositol 3-kinase/mammalian target of Rapamycin inhibitors, enhance tumor and endothelial cell …
- An elaborate regulation of Mammalian target of Rapamycin activity is required for somatic cell reprogramming induced by defined transcription factors
- Rapamycin-induced posterior reversible encephalopathy in a kidney transplantation patient
- Mammalian target of Rapamycin pathway activation is associated to RET mutation status in medullary thyroid carcinoma
- … secretion via down-regulation of surface expression of adrenergic α2A receptor through the mTOR (mammalian target of Rapamycin) pathway: implication in …
- Rapamycin enhances docetaxel-induced cytotoxicity in a androgen-independent prostate cancer xenograft model by survivin downregulation
- Beta cell function during Rapamycin monotherapy in long-term type 1 diabetes
- Temporal regulation of Rapamycin on memory CTL programming by IL-12
- Rapamycin prevents endothelial cell migration by inhibiting the endothelial-to-mesenchymal transition and matrix metalloproteinase-2 and-9: an in vitro study
- TGFβ‐and bleomycin‐induced extracellular matrix synthesis is mediated through Akt and mammalian target of Rapamycin (mTOR)
- cAMP inhibits mammalian target of Rapamycin complex-1 and-2 (mTORC1 and 2) by promoting complex dissociation and inhibiting mTOR kinase activity
- Enhanced delivery of Rapamycin by V156K-apoA-I high-density lipoprotein inhibits cellular proatherogenic effects and senescence and promotes tissue regeneration
- Interpreting mammalian target of Rapamycin and cell growth inhibition in a genetically engineered mouse model of Nf1-deficient astrocytes
- First report of a novel abluminal groove filled biodegradable polymer Rapamycin-eluting stent in de novo coronary artery disease: results of the first in man FIREHAWK …
- Autophagy induced by Rapamycin and carbon‐starvation have distinct proteome profiles in Aspergillus nidulans
- An emerging role for the mammalian target of Rapamycin in “pathological” protein translation: relevance to cocaine addiction
- Rapamycin-cyclodextrin complexation: improved solubility and dissolution rate
- inhibition of autophagy as a strategy to augment radiosensitization by the dual phosphatidylinositol 3-kinase/mammalian target of Rapamycin inhibitor NVP-BEZ235
- Regulation of mammalian target of Rapamycin and mitogen activated protein kinase pathways by BCR–ABL
- mTOR in podocyte function: is Rapamycin good for diabetic nephropathy?
- Yin Yang 1 deficiency in skeletal muscle protects against Rapamycin-induced diabetic-like symptoms through activation of insulin/IGF signaling
- ULK1, mammalian target of Rapamycin, and mitochondria: linking nutrient availability and autophagy
- Mammalian target of Rapamycin mediates the angiogenic effects of leptin in human hepatic stellate cells
- Forced degradation studies of Rapamycin: Identification of autoxidation products
- Inactivation of mammalian target of Rapamycin (mTOR) by Rapamycin in a murine model of lipopolysaccharide-induced acute lung injury
- Pharmacological targeting of mammalian target of Rapamycin inhibits ovarian granulosa cell tumor growth
- Innovations therapy: mammalian target of Rapamycin (mTOR) inhibitors for the treatment of neuroendocrine tumors
- Nitrogen-responsive regulation of GATA protein family activators Gln3 and Gat1 occurs by two distinct pathways, one inhibited by Rapamycin and the other by …
- Myopathy caused by mammalian target of Rapamycin complex 1 (mTORC1) inactivation is not reversed by restoring mitochondrial function
- Remarkable inhibition of mTOR signaling by the combination of Rapamycin and 1, 4‐phenylenebis (methylene) selenocyanate in human prostate cancer cells
- Regulatory T cells expanded by Rapamycin in vitro suppress colitis in an experimental mouse model
- Combination of an allosteric Akt Inhibitor MK-2206 with etoposide or Rapamycin enhances the antitumor growth effect in neuroblastoma
- Localized ultrasound enhances delivery of Rapamycin from microbubbles to prevent smooth muscle proliferation
- inhibition of Akt (ser473) phosphorylation and Rapamycin-resistant cell growth by knockdown of mammalian target of Rapamycin with small interfering RNA in vascular …
