SHBG
May 20, 2022EXTENDS LIFESPAN
May 20, 2022- Identification of UBIAD1 as a novel human menaquinone–4 biosynthetic enzyme
- Comparison of menaquinone–4 and menaquinone-7 bioavailability in healthy women
- Conversion of phylloquinone (Vitamin K1) into menaquinone–4 (Vitamin K2) in mice: two possible routes for menaquinone–4 accumulation in cerebra of mice
- Intestinal flora is not an intermediate in the phylloquinone-menaquinone–4 conversion in the rat
- Phylloquinone and menaquinone–4 distribution in rats: synthesis rather than uptake determines menaquinone–4 organ concentrations
- Vitamin K status in human tissues: tissue-specific accumulation of phylloquinone and menaquinone–4
- Conversion of dietary phylloquinone to tissue menaquinone–4 in rats is not dependent on gut bacteria
- Tissue-specific utilization of menaquinone–4 results in the prevention of arterial calcification in warfarin-treated rats
- Vitamin K distribution in rat tissues: dietary phylloquinone is a source of tissue menaquinone–4
- menaquinone–4 concentration is correlated with sphingolipid concentrations in rat brain
- Prevention of hepatocarcinogenesis with phosphatidylcholine and menaquinone–4: in vitro and in vivo experiments
- Neuroprotective effect of menaquinone–4 (MK-4) on transient global cerebral ischemia/reperfusion injury in rat
- Multiple dietary vitamin K forms are converted to tissue menaquinone–4 in mice
- Colonic absorption of menaquinone–4 and menaquinone-9 in rats
- menaquinone–4 in breast milk is derived from dietary phylloquinone
- menaquinone–4 accumulation in various tissues after and oral administration of phylloquinone in Wistar rats
- menaquinone–4 enhances testosterone production in rats and testis-derived tumor cells
- Combinatorial engineering for improved menaquinone–4 biosynthesis in Bacillus subtilis
- Effects of long-term vitamin K1 (phylloquinone) or vitamin K2 (menaquinone–4) supplementation on body composition and serum parameters in rats
- … (vitamin K3) is a catabolic product of oral phylloquinone (vitamin K1) in the intestine and a circulating precursor of tissue menaquinone–4 (vitamin K2) in rats
- Vitamin K metabolism. menaquinone–4 (MK-4) formation from ingested VK analogues and its potent relation to bone function
- Deuterium-labeled phylloquinone has tissue-specific conversion to menaquinone–4 among Fischer 344 male rats
- Menaquinone 4 increases plasma lipid levels in hypercholesterolemic mice
- Possible effects of one week vitamin K (menaquinone–4) tablets intake on glucose tolerance in healthy young male volunteers with different descarboxy prothrombin …
- Identification of menaquinone–4 metabolites in the rat
- Vitamin K2 (menaquinone 4) reduces serum undercarboxylated osteocalcin level as early as 2 weeks in elderly women with established osteoporosis
- Anti‐arthritis effects of vitamin K2 (menaquinone‐4) − a new potential therapeutic strategy for rheumatoid arthritis
- Comparative uptake, metabolism, and utilization of menaquinone–4 and phylloquinone in human cultured cell lines
- Impact of menaquinone–4 supplementation on coronary artery calcification and arterial stiffness: an open label single arm study
- Elucidation of the mechanism producing menaquinone–4 in osteoblastic cells
- Engineering a ComA Quorum-Sensing circuit to dynamically control the production of menaquinone–4 in Bacillus subtilis
- Vitamin K in milk and infant formulas: determination and distribution of phylloquinone and menaquinone–4
- Vitamin K1 (phylloquinone) and K2 (menaquinone–4) supplementation improves bone formation in a high-fat diet-induced obese mice
- LC–MS/MS quantitative analysis of phylloquinone, menaquinone–4 and menaquinone-7 in the human serum of a healthy population
- menaquinone–4 suppresses lipopolysaccharide-induced inflammation in MG6 mouse microglia-derived cells by inhibiting the NF-κB signaling pathway
- Age and dietary form of vitamin K affect menaquinone–4 concentrations in male Fischer 344 rats
- Atorvastatin decreases renal menaquinone–4 formation in C57BL/6 male mice
- menaquinone–4 Production by a Mutant of Flavobacterium sp. 238-7
- Structure–Activity Relationship of Novel menaquinone–4 Analogues: Modification of the Side Chain Affects their Biological Activities
- Rapid, high performance method for the determination of vitamin K1, menaquinone–4 and vitamin K1 2, 3-epoxide in human serum and plasma using liquid …
- Daily intake and serum concentration of menaquinone–4 (MK-4) in haemodialysis patients with chronic kidney disease
- menaquinone‐4 enhances osteogenic potential of human amniotic fluid mesenchymal stem cells cultured in 2D and 3D dynamic culture systems
- Vitamin K1 (phylloquinone) or vitamin K2 (menaquinone–4) induces intestinal alkaline phosphatase gene expression
- Tissue distribution of phylloquinone and menaquinone–4 in sardine, Sardinops melanostictus
- Enhancement effects of vitamin K1 (phylloquinone) or vitamin K2 (menaquinone–4) on intestinal alkaline phosphatase activity in rats
- Extracellular production of menaquinone–4 by a mutant of Flavobacterium sp. 238-7 with a detergent-supplemented culture
- Vitamin E decreases extra‐hepatic menaquinone‐4 concentrations in rats fed menadione or phylloquinone
- Isolation and characterization of menaquinone–4 as a product of menadione metabolism in chicks and rats.
- menaquinone–4 (vitamin K2) up-regulates expression of human intestinal alkaline phosphatase in Caco-2 cells
- … –activity relationships in the conversion of vitamin K analogues into menaquinone–4. Substrates essential to the synthesis of menaquinone–4 in cultured human cell …
- Low-dose menaquinone–4 improves γ-carboxylation of osteocalcin in young males: a non-placebo-controlled dose–response study
- menaquinone–4 (vitamin K2) induces proliferation responses in bovine peripheral blood mononuclear cells
- Osteogenic transdifferentiation of vascular smooth muscle cells isolated from spontaneously hypertensive rats and potential menaquinone‐4 inhibiting effect
- A comparatively study of menaquinone-7 isolated from Cheonggukjang with vitamin K1 and menaquinone–4 on osteoblastic cells differentiation and mineralization
- Menaquinone 4 Reduces Bone Loss in Ovariectomized Mice through Dual Regulation of Bone Remodeling
- Circulating levels of vitamin K1, menaquinone–4, and menaquinone-7 in healthy elderly Japanese women and patients with vertebral fractures and patients with hip …
- The formation of menaquinone–4 (vitamin K) and its oxide in some marine invertebrates
- Effects of dietary vitamin K on survival, growth, and tissue concentrations of phylloquinone (PK) and menaquinone–4 (MK-4) for juvenile abalone, Haliotis discus …
- The relative effects of phylloquinone and menaquinone–4 on the blood coagulation factor synthesis in vitamin K-deficient rats
- menaquinone–4 amplified glucose-stimulated insulin secretion in isolated mouse pancreatic islets and INS-1 rat insulinoma cells
- Phylloquinone and menaquinone–4 tissue distribution at different life stages in male and female Sprague–Dawley rats fed different VK levels since weaning or …
- … -phase HPLC determination of chlorophyll a′ and naphthoquinones in photosystem I of red algae: existence of two menaquinone–4 molecules in photosystem I of …
- menaquinone–4 Production by a Sulfonamide-resistant Mutant of Flavobacterium sp. 238–7
- Changes of phylloquinone and menaquinone–4 concentrations in rat liver after oral, intravenous and intraperitoneal administration.
- Enhanced antitumor effects of novel intracellular delivery of an active form of menaquinone–4, menahydroquinone-4, into hepatocellular carcinoma
- menaquinone–4 accelerates calcification of human aortic valve interstitial cells in high-phosphate medium through PXR
- Concentrations of circulating phylloquinone, but not cerebral menaquinone–4, are positively correlated with a wide range of cognitive measures: exploratory findings in …
- Deuterium‐labeled phylloquinone fed to α‐tocopherol‐injected rats demonstrates sensitivity of low phylloquinone‐containing tissues to menaquinone‐4 depletion
- Distribution of menaquinone–4, a therapeutic agent for osteoporosis, in bone and other tissues of rats
- Determination of vitamin K1 in canola oils by high performance liquid chromatography with menaquinone–4 as an internal standard
- Effects of combined menaquinone–4 and PTH1–34 treatment on osetogenesis and angiogenesis in calvarial defect in osteopenic rats
- The Biosynthesis of menaquinone–4: How a Historic Biochemical Pathway Is Changing Our Understanding of Vitamin K Nutrition
- Plasma phylloquinone, menaquinone–4 and menaquinone-7 levels and coronary artery calcification
- Excess α‐tocopherol decreases extrahepatic phylloquinone in phylloquinone‐fed rats but not menaquinone‐4 in menaquinone‐4‐fed rats
- menaquinone‑4 modulates the expression levels of calcification‑associated factors to inhibit calcification of rat aortic vascular smooth muscle cells in a dose …
- Exocrine pancreatic secretion of phospholipid, menaquinone–4, and caveolin-1 in vivo
- menaquinone–4 and-5 in a bacterium.
- Pharmacokinetic characterization of menaquinone–4 in dogs by sensitive HPLC determination
- Simultaneous determination of vitamin K1, vitamin K1 2, 3-epoxide and menaquinone–4 in human plasma by high-performance liquid chromatography with fluorimetric …
- Maximal dose-response of vitamin-K2 (menaquinone–4) on undercarboxylated osteocalcin in women with osteoporosis
- Excretion of menaquinone–4 by a Mutant of Flavobacterium sp. 238-7 in a Detergent-supplemented Culture
- Reversed phase uplc/apci-ms determination of vitamin k1 and menaquinone–4 in human plasma: Application to a clinical study
- Genistein and menaquinone–4 treatment-induced alterations in the expression of mRNAs and their products are beneficial to osteoblastic MC3T3-E1 cell …
- Development of a liquid chromatography mass spectrometry method for the determination of vitamin K1, menaquinone–4, menaquinone-7 and vitamin K1-2, 3 epoxide …
- The placental and mammary transport of [14C] menaquinone–4 in rats
- Effect of solubilizer on the metabolic fate of menaquinone–4 in rats
- Selective Release of menaquinone–4 from Cells of a Mutant of Flavobacterium sp. 238–7 with a Detergent
- Stereobiochemical aspects of warfarin isomers for inhibition of enzymatic alkylation of menaquinone-0 to menaquinone–4 in chick liver.
- The secondary electron acceptor of photosystem I in Gloeobacter violaceus PCC 7421 is menaquinone–4 that is synthesized by a unique but unknown …
- Interactions and structure—organizations of menaquinone–4 and egg yolk phosphatidylcholine mixtures: Formation of bilayer and nonbilayer structures in an aqueous …
- Enzymatic Alteration in the Shikimate Pathway during Derivation of menaquinone–4-producing Mutants of Flavobacterium sp. 238-7
- Simultaneous determination of menaquinone–4 and its metabolite in human osteoblasts by high-performance liquid chromatography/atmospheric pressure chemical …
- Upregulation of thrombomodulin antigen levels in u937 cells by combined stimulation with estradiol-17β and vitamin K2 (menaquinone 4)
- Supplementation of rats with a lutein mixture preserved with vitamin E reduces tissue phylloquinone and menaquinone–4
- Changes of K vitamins in portal and femoral venous plasma of rats after oral administration of phylloquinone and menaquinone–4.
- The effect of menaquinone–4 administration on the expression of proinflammatory factors following transient global cerebral ischemia/reperfusion in the hippocampus …
- … of isoprenoid quinones. I. Separation of homologues, geometrical isomers and decomposition products of phylloquinone, menaquinone–4 and ubiquinone-10
- Dietary intake of menaquinone–4 may determine hepatic and pancreatic menaquinone–4 in chickens
- Vitamin K (menaquinone–4) metabolism in liver disease
- Metabolic fate of menaquinone–4 in dogs (I): Absorption, distribution, metabolism and excretion after a single oral administration
- Effects of combined human parathyroid hormone (1–34) and menaquinone–4 treatment on the interface of hydroxyapatite-coated titanium implants in the femur of …
- Synthetic studies on isoprenoidquinones. II. Syntheses of Ubiquinone-10, phylloquinone, and menaquinone–4 by a chain-extending method utilizing terminally …
- The Interaction of menaquinone–4 with Phopholipid Membranes
- Simultaneous Determination of Vitamins D3 (Calcitriol, Cholecalciferol) and K2 (menaquinone–4 and menaquinone-7) in Dietary Supplements by UHPLC
- Atorvastatin Decreases menaquinone‐4 Formation in C57Bl6 Male Mice
- New Development of Vitamin K Research: Identification of Human menaquinone–4 Biosynthetic Enzyme.
- Synthesis of all trans [3′‐14C]menaquinone‐4
- 2. DELTA.-Stereocontrolled Entry to (E)-or (Z)-Prenyl Aromatics and Quinones. Synthesis of menaquinone–4
- Enhanced Intracellular Delivery and Improved Antitumor Efficacy of menaquinone–4
- An UFLC-DAD Method for the Quantification of menaquinone–4 in Spiked Rabbit Plasma
- Simultaneous Determination of menaquinone–4 and Its Metabolite in Human Osteoblasts by High-Performance Liquid Chromatography/Atmospheric Pressure …
- Menaquinone 4 Alters Plasma Lipid Profile In Hypercholesterolemic Mice
- Metabolic Fate of menaquinone–4 in Dogs (II): Absorption, Distribution, Metabolism and Excretion after Repeated Oral Administration
- Effect of vitamin K2 (menaquinone–4) and vitamin D3 on bone mineralization in young and adult female rats
- The effect of menaquinone–4 administration on the expression of pro-inflammatory factors following transient global cerebral ischemia/reperfusion in the hippocampus …
- Vitamin K Tissue Distribution Is Modified by Large-Dose Warfarin and menaquinone–4 Content of the Diet
- Synthesis Vitamin K Derivatives with High Conversion Rates to menaquinone–4
- The Enzymatic Conversion of Phylloquinone to menaquinone–4
- Menadione is an Intermediate in the Phylloquinone to menaquinone‐4 Conversion
- … Develop and Validate a UPLC-QToFMS Method for Simultaneous Estimation of Ergocalciferol, Cholecalciferol, Phylloquinone, menaquinone–4, menaquinone-7, and …
- Conversion of phylloquinone to menaquinone–4 in chickens, rats and cultured cells
- Mode of Action of menaquinone–4 on Blood Coagulation
- menaquinone–4 effects on working memory impairment and anxiety behavior after transient cerebral ischemia/reperfusion in male wistar rat
- Correlation between serum concentrations of menaquinone–4 and developmental quotients in children with autism spectrum disorder
- The effect of vitamin K2 (menaquinone–4) on the cognitive impairments and anxiety in transient cerebral global Ischemia
- Reduction of ovariectomy-induced bone loss in rats by menaquinone–4, cholecalciferol, and (n-3) polyunsaturated fats
- Tissue‐Specific Proportions of Phylloquinone to menaquinone‐4 Concentrations Differ in Response to Dietary Phylloquinone Manipulation in Lean Male Zucker Rats
- Oral Administration of Cal K2 Containing menaquinone–4 (Vitamin K2) Enhances Serum r-Carboxylated Osteocalcin and Biochemical Components in the Femoral …
- A Rationale for an Approach to Preventing and Treating Bisphosphonate-related Osteonecrosis of the Jaw With Vitamin K2 menaquinone–4
- Changes in analgesia and hyperalgesia induced by intraperitoneal administration of morphine in the formalin test during intrathecal administration of menaquinone–4 …
- UBIAD1 combined with menaquinone–4 induce aPoPtosis in human bladder carcinoma T24 cell line via c-Jun N-terminal Kinase/P53 Pathways
- 5.2. 3 Tissue-specific proportions of phylloquinone to menaquinone–4 concentrations differ in response to dietary phylloquinone manipulation in lean male Zucker rats
- A methyl 4-oxo-4-phenylbut-2-enoate with in vivo activity against MRSA that inhibits MenB in the bacterial menaquinone biosynthesis pathway
- Bioconversion of farnesol and 1, 4-dihydroxy-2-naphthoate to menaquinone by an immobilized whole-cell biocatalyst using engineered Elizabethkingia …
- The acid–base and redox properties of menaquinone MK-4, MK-7, and MK-9 (vitamin K2) in DMPC monolayers on mercury
- Aerobic culture of Propionibacterium freudenreichii ET-3 can increase production ratio of 1, 4-dihydroxy-2-naphthoic acid to menaquinone
- PROGRESS TOWARDS THE SYNTHESIS OF THE SUBSTRATE FOR THE BACTERIAL menaquinone BIOSYNTHETIC ENZYME, 1, 4-DIHYDROXY-6 …
- Design, synthesis and antitumor activity of phthalazine-1, 4-dione-based menaquinone analogs
