REVERSAL OF OBESITY
September 23, 2022ORGANOTINS
September 23, 2022- Phosphatidylinositol 3‐kinase
- Activation of Phosphatidylinositol 3–kinase by insulin.
- The activation of Phosphatidylinositol 3–kinase by Ras
- Association of focal adhesion kinase with its potential substrate Phosphatidylinositol 3–kinase.
- Phosphatidylinositol 3–kinase related kinases
- Phosphatidylinositol 3–kinase Encoded by Yeast VPS34 Gene Essential for Protein Sorting
- Phosphatidylinositol 3–kinase: structure and expression of the 110 kd catalytic subunit
- Wortmannin is a potent Phosphatidylinositol 3–kinase inhibitor: the role of Phosphatidylinositol 3, 4, 5-trisphosphate in neutrophil responses
- Requirement for Phosphatidylinositol–3 kinase in the prevention of apoptosis by nerve growth factor
- Ras-dependent induction of cellular responses by constitutively active Phosphatidylinositol–3 kinase
- Activation of Phosphatidylinositol–3′ kinase by Src-family kinase SH3 binding to the p85 subunit
- Phosphatidylinositol 3′‐kinase is activated by association with IRS‐1 during insulin stimulation.
- A human Phosphatidylinositol 3‐kinase complex related to the yeast Vps34p‐Vps15p protein sorting system.
- Wortmannin, a potent and selective inhibitor of Phosphatidylinositol–3–kinase
- A specific inhibitor of Phosphatidylinositol 3–kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).
- The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated Phosphatidylinositol 3–kinase
- Membrane localization of Phosphatidylinositol 3–kinase is sufficient to activate multiple signal-transducing kinase pathways
- The Phosphatidylinositol 3–kinase alpha is required for DNA synthesis induced by some, but not all, growth factors.
- Cloning of a novel, ubiquitously expressed human Phosphatidylinositol 3–kinase and identification of its binding site on p85
- Inhibition of Phosphatidylinositol 3–kinase activity by association with 14-3–3 proteins in T cells.
- Phosphatidylinositol 3‘kinase: one of the effectors of Ras
- Association of p21ras with Phosphatidylinositol 3–kinase.
- Interaction of Phosphatidylinositol 3–kinase-associated p85 with epidermal growth factor and platelet-derived growth factor receptors
- ErbB3 is involved in activation of Phosphatidylinositol 3–kinase by epidermal growth factor
- Phosphatidylinositol–3 kinase activity is regulated by BCR/ABL and is required for the growth of Philadelphia chromosome-positive cells
- Activation of the Eck receptor protein tyrosine kinase stimulates Phosphatidylinositol 3–kinase activity.
- Phosphatidylinositol 3–kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation
- The inhibition of Phosphatidylinositol 3–kinase by quercetin and analogs
- Phosphatidylinositol 3–kinase inhibitors block differentiation of skeletal muscle cells
- Studies on the mechanism of Phosphatidylinositol 3–kinase inhibition by wortmannin and related analogs
- CD19 of B cells as a surrogate kinase insert region to bind Phosphatidylinositol 3–kinase
- DNA-dependent protein kinase catalytic subunit: a relative of Phosphatidylinositol 3–kinase and the ataxia telangiectasia gene product
- Involvement of Phosphatidylinositol 3–kinase in Fc gamma receptor signaling.
- The interaction of small domains between the subunits of Phosphatidylinositol 3–kinase determines enzyme activity
- Interkinase domain of kit contains the binding site for Phosphatidylinositol 3‘kinase.
- Mechanism of down-regulation of c-kit receptor. Roles of receptor tyrosine kinase, Phosphatidylinositol 3‘-kinase, and protein kinase C.
- Mouse p170 is a novel Phosphatidylinositol 3–kinase containing a C2 domain
- Inhibition of the Phosphatidylinositol 3–kinase/p70S6-kinase pathway induces B16 melanoma cell differentiation
- Epidermal growth factor-dependent association of Phosphatidylinositol 3–kinase with the erbB3 gene product.
- The structure and function of p55PIK reveal a new regulatory subunit for Phosphatidylinositol 3–kinase
- Phosphatidylinositol 3–kinase and its novel product, Phosphatidylinositol 3-phosphate, are present in Saccharomyces cerevisiae
- Phosphatidylinositol 3–kinase Is an Early Intermediate in the Gβγ-mediated Mitogen-activated Protein kinase Signaling Pathway (∗)
- Phosphatidylinositol (3, 4, 5) P3 interacts with SH2 domains and modulates PI 3–kinase association with tyrosine-phosphorylated proteins
- Rac GTPase interacts specifically with Phosphatidylinositol 3–kinase
- The Phosphatidylinositol 3–kinase serine kinase phosphorylates IRS-1. Stimulation by insulin and inhibition by Wortmannin.
- Insulin stimulation of Phosphatidylinositol 3–kinase activity and association with insulin receptor substrate 1 in liver and muscle of the intact rat.
- A novel recognition motif for Phosphatidylinositol 3–kinase binding mediates its association with the hepatocyte growth factor/scatter factor receptor
- In vitro and in vivo antitumor activity of the Phosphatidylinositol–3–kinase inhibitor, wortmannin.
- Essential role of Phosphatidylinositol 3–kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. Studies with a selective inhibitor …
- Activation of Phosphatidylinositol 3–kinase in cells expressing abl oncogene variants
- Regulation of Phosphatidylinositol 3–kinase activity in liver and muscle of animal models of insulin-resistant and insulin-deficient diabetes mellitus.
- EGF or PDGF receptors activate atypical PKClambda through Phosphatidylinositol 3‐kinase.
- T-cell antigen CD28 interacts with the lipid kinase Phosphatidylinositol 3–kinase by a cytoplasmic Tyr (P)-Met-Xaa-Met motif.
- Investigation of neutrophil signal transduction using a specific inhibitor of Phosphatidylinositol 3–kinase.
- Evidence for Phosphatidylinositol 3–kinase as a regulator of endocytosis via activation of Rab5.
- The tyrosine-phosphorylated hepatocyte growth factor/scatter factor receptor associates with Phosphatidylinositol 3–kinase.
- Insulin activates a p21-activated kinase in muscle cells via Phosphatidylinositol 3–kinase
- Phosphatidylinositol 3–kinase signals activate a selective subset of Rac/Rho-dependent effector pathways
- Inhibition of histamine secretion by wortmannin through the blockade of Phosphatidylinositol 3–kinase in RBL-2H3 cells.
- Phosphatidylinositol 3–kinase binds to α-actinin through the p85 subunit
- Phospholipase C-γ1 and Phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor’s mitogenic signal
- Identification of c‐erbB‐3 binding sites for Phosphatidylinositol 3′‐kinase and SHC using an EGF receptor/c‐erbB‐3 chimera.
- Akt Is a Direct Target of the Phosphatidylinositol 3–kinase: ACTIVATION BY GROWTH FACTORS, v-src and v-Ha-ras, IN Sf9 AND MAMMALIAN CELLS
- SH2 domains of the p85 alpha subunit of Phosphatidylinositol 3–kinase regulate binding to growth factor receptors
- Role for Phosphatidylinositol 3–kinase in the sorting and transport of newly synthesized lysosomal enzymes in mammalian cells.
- Oligodendrocytes and their precursors require Phosphatidylinositol 3–kinase signaling for survival
- Inhibition of the translocation of GLUT1 and GLUT4 in 3T3-L1 cells by the Phosphatidylinositol 3–kinase inhibitor, wortmannin
- Identification of Trk binding sites for SHC and Phosphatidylinositol 3‘-kinase and formation of a multimeric signaling complex.
- Phosphatidylinositol 3–kinase activity is required for early endosome fusion
- CTLA-4 binding to the lipid kinase Phosphatidylinositol 3–kinase in T cells.
- Wortmannin, a specific inhibitor of Phosphatidylinositol–3 kinase, blocks osteoclastic bone resorption
- Activation of RAC-protein kinase by heat shock and hyperosmolarity stress through a pathway independent of Phosphatidylinositol 3–kinase.
- Dominant missense mutations in a novel yeast protein related to mammalian Phosphatidylinositol 3–kinase and VPS34 abrogate rapamycin cytotoxicity
- Membrane ruffling and chemotaxis transduced by the PDGF beta-receptor require the binding site for Phosphatidylinositol 3‘kinase.
- Molecular cloning, cDNA sequence, and chromosomal localization of the human Phosphatidylinositol 3–kinase p110α (PIK3CA) gene
- Phosphatidylinositol 3–kinase Activity Is Required at a Postendocytic Step in Platelet-derived Growth Factor Receptor Trafficking∗
- Requirement of Phosphatidylinositol–3 kinase modification for its association with p60src
- Neurite outgrowth of PC12 cells is suppressed by wortmannin, a specific inhibitor of Phosphatidylinositol 3–kinase.
- Phosphorylation of the PDGF receptor beta subunit creates a tight binding site for Phosphatidylinositol 3 kinase.
- CD28 of T lymphocytes associates with Phosphatidylinositol 3–kinase
- The v-Src SH3 domain binds Phosphatidylinositol 3‘-kinase
- Signal transduction via CD40 involves activation of lyn kinase and Phosphatidylinositol–3–kinase, and phosphorylation of phospholipase C gamma 2.
- Blockage of chemotactic peptide-induced stimulation of neutrophils by wortmannin as a result of selective inhibition of Phosphatidylinositol 3–kinase.
- Hepatocyte growth factor-induced scatter of Madin-Darby canine kidney cells requires Phosphatidylinositol 3–kinase
- Role of Phosphatidylinositol–3–kinase in insulin receptor signaling: studies with inhibitor, LY294002
- Identification of two SH3-binding motifs in the regulatory subunit of Phosphatidylinositol 3–kinase.
- Acute regulation by insulin of Phosphatidylinositol–3–kinase, Rad, Glut 4, and lipoprotein lipase mRNA levels in human muscle.
- Phosphatidylinositol 3‐kinase regulation of fluid phase endocytosis
- Phosphatidylinositol 3–kinase activation in normal human B lymphocytes.
- Wortmannin, a specific Phosphatidylinositol 3–kinase inhibitor, inhibits adipocytic differentiation of 3T3-L1 cells
- A Phosphatidylinositol–3 kinase binds to platelet-derived growth factor receptors through a specific receptor sequence containing phosphotyrosine
- Solution structure and ligand-binding site of the SH3 domain of the p85α subunit of Phosphatidylinositol 3–kinase
- Polyphosphoinositides produced by Phosphatidylinositol 3–kinase are poor substrates for phospholipases C from rat liver and bovine brain
- Stimulation of CD28 triggers an association between CD28 and Phosphatidylinositol 3–kinase in Jurkat T cells.
- A comparison of demethoxyviridin and wortmannin as inhibitors of Phosphatidylinositol 3‐kinase
- Activated Phosphatidylinositol 3–kinase is sufficient to mediate actin rearrangement and GLUT4 translocation in 3T3-L1 adipocytes
- Interactions of Cbl with Grb2 and Phosphatidylinositol 3‘-kinase in activated Jurkat cells
- Membrane Ig cross-linking regulates Phosphatidylinositol 3–kinase in B lymphocytes.
- Growth factor-dependent survival of rodent fibroblasts requires Phosphatidylinositol 3–kinase but is independent of pp70S6K activity.
- Selective CD28pYMNM mutations implicate Phosphatidylinositol 3–kinase in CD86-CD28-mediated costimulation
- Direct activation of the Phosphatidylinositol 3‘-kinase by the insulin receptor.
- Nerve growth factor promotes the activation of Phosphatidylinositol 3–kinase and its association with the trk tyrosine kinase.
- … factor activates protein kinase C epsilon through redundant and independent signaling pathways involving phospholipase C gamma or Phosphatidylinositol 3–kinase.
- Phosphorylation of middle T by pp60c-src: a switch for binding of Phosphatidylinositol 3–kinase and optimal tumorigenesis
- Activation of Src-like protein-tyrosine kinase Lyn and its association with Phosphatidylinositol 3–kinase upon B-cell antigen receptor-mediated signaling.
- Direct Association of Grb2 with the p85 Subunit of Phosphatidylinositol 3–kinase (∗)
- Overexpression of a constitutively active form of Phosphatidylinositol 3–kinase is sufficient to promote Glut 4 translocation in adipocytes
- Antagonists of Phosphatidylinositol 3–kinase block activation of several novel protein kinases in neutrophils
- Interleukin-2 triggers a novel Phosphatidylinositol 3–kinase-dependent MEK activation pathway
- GTPase-activating protein and Phosphatidylinositol 3–kinase bind to distinct regions of the platelet-derived growth factor receptor beta subunit
- Defect in skeletal muscle Phosphatidylinositol–3–kinase in obese insulin-resistant mice.
- Protein kinase C δ specifically associates with Phosphatidylinositol 3–kinase following cytokine stimulation
- p56Lck and p59Fyn regulate CD28 binding to Phosphatidylinositol 3–kinase, growth factor receptor-bound protein GRB-2, and T cell-specific protein-tyrosine kinase …
- Phosphatidylinositol 3–kinase activation is mediated by high-affinity interactions between distinct domains within the p110 and p85 subunits
- AtVPS34, a Phosphatidylinositol 3–kinase of Arabidopsis thaliana, is an essential protein with homology to a calcium-dependent lipid binding domain.
- Efficient coupling with Phosphatidylinositol 3–kinase, but not phospholipase C gamma or GTPase-activating protein, distinguishes ErbB-3 signaling from that of other …
- Requirement for Phosphatidylinositol 3–kinase in epidermal growth factor-induced AP-1 transactivation and transformation in JB6 P+ cells
- Modulation of insulin receptor, insulin receptor substrate-1, and Phosphatidylinositol 3–kinase in liver and muscle of dexamethasone-treated rats.
- Adrenergic Receptors Activate Phosphatidylinositol 3–kinase in Human Vascular Smooth Muscle Cells: ROLE IN MITOGENESIS (∗)
- Phosphatidylinositol–3 kinase activation induced upon Fc gamma RIIIA-ligand interaction.
- Phosphatidylinositol 3–kinase is activated by nerve growth factor and epidermal growth factor in PC12 cells.
- Insulin-stimulated Phosphatidylinositol 3–kinase. Association with a 185-kDa tyrosine-phosphorylated protein (IRS-1) and localization in a low density …
- Regulation of Phosphatidylinositol 3′-kinase by tyrosyl phosphoproteins: full activation requires occupancy of Both SH2 domains in the 85-kDa regulatory …
- Wortmannin causes mistargeting of procathepsin D. evidence for the involvement of a Phosphatidylinositol 3–kinase in vesicular transport to lysosomes.
- Phosphatidylinositol 3–kinase associates, via its Src homology 2 domains, with the activated erythropoietin receptor
- Phosphatidylinositol 3–kinase mediates the inhibitory effect of epidermal growth factor on calcium-dependent chloride secretion
- The Phosphatidylinositol 3–kinase Inhibitor Wortmannin Sensitizes Murine Fibroblasts and Human Tumor Cells to Radiation and Blocks Induction of p53 following …
- 1-Phosphatidylinositol 3–kinase activity is required for insulin-stimulated glucose transport but not for RAS activation in CHO cells.
- The inability of Phosphatidylinositol 3–kinase activation to stimulate GLUT4 translocation indicates additional signaling pathways are required for insulin-stimulated …
- Insulin stimulation of Phosphatidylinositol 3–kinase activity maps to insulin receptor regions required for endogenous substrate phosphorylation.
- Overexpression of catalytic subunit p110α of Phosphatidylinositol 3–kinase increases glucose transport activity with translocation of glucose transporters in …
- Platelet-derived growth factor-induced Phosphatidylinositol 3–kinase activation mediates actin rearrangements in fibroblasts
- Regulated coupling of the Neu receptor to Phosphatidylinositol 3‘-kinase and its release by oncogenic activation.
- Requirement for Phosphatidylinositol 3‘-kinase to protect hemopoietic progenitors against apoptosis depends upon the extracellular survival factor.
- The proto-oncogene product p120CBL and the adaptor proteins CRKL and c-CRK link c-ABL, p190BCR/ABL and p210BCR/ABL to the Phosphatidylinositol–3‘kinase …
- Internalization of activated platelet-derived growth factor receptor-Phosphatidylinositol–3‘kinase complexes: potential interactions with the microtubule cytoskeleton
- A regulatory role for cAMP in Phosphatidylinositol 3–kinase/p70 ribosomal S6 kinase-mediated DNA synthesis in platelet-derived-growth-factor-stimulated bovine …
- Phosphatidylinositol 3–kinase signals activation of p70 S6 kinase in situ through site-specific p70 phosphorylation.
- Bacterial lipopolysaccharide induces the association and coordinate activation of p53/56lyn and Phosphatidylinositol 3–kinase in human monocytes.
- Two types of Phosphatidylinositol 3–kinase from bovine thymus. Monomer and heterodimer form
- Multiple roles of Phosphatidylinositol 3–kinase in regulation of glucose transport, amino acid transport, and glucose transporters in L6 skeletal muscle cells
- Stimulation of Phosphatidylinositol 3‘-kinase association with foca adhesion kinase by platelet-derived growth factor.
- Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation, and Phosphatidylinositol 3–kinase activity are decreased in intact skeletal muscle strips …
- Association of Phosphatidylinositol 3–kinase with SHC in chronic myelogeneous leukemia cells.
- Both Phosphatidylinositol 3–kinase and Phosphatidylinositol 4-kinase products are increased by antigen receptor signaling in B cells.
- Profilin and gelsolin stimulate Phosphatidylinositol 3–kinase activity
- Phosphorylation of tyrosine 397 in focal adhesion kinase is required for binding Phosphatidylinositol 3–kinase
- … Inhibit Stimulated Phospholipase A2 Activity in Swiss 3T3 Cells: WORTMANNIN IS NOT A SPECIFIC INHIBITOR OF Phosphatidylinositol 3–kinase (∗ …
- Insulin and insulinomimetic agents induce activation of Phosphatidylinositol 3‘-kinase upon its association with pp185 (IRS-1) in intact rat livers.
- Multiple cytokines activate Phosphatidylinositol 3–kinase in hemopoietic cells. Association of the enzyme with various tyrosine-phosphorylated proteins.
- IRS-1 activates Phosphatidylinositol 3‘-kinase by associating with src homology 2 domains of p85.
- Requirement of Phosphatidylinositol–3 kinase for epithelial cell migration activated by human macrophage stimulating protein.
- Effect of aging on insulin receptor, insulin receptor substrate-1, and Phosphatidylinositol 3–kinase in liver and muscle of rats
- Biased combinatorial libraries: novel ligands for the SH3 domain of Phosphatidylinositol 3–kinase
- IRS-1 is a common element in insulin and insulin-like growth factor-I signaling to the Phosphatidylinositol 3‘-kinase
- Phosphatidylinositol 3–kinase Recruitment by p185erbB-2 and erbB-3 Is Potently Induced by neu Differentiation Factor/Heregulin during Mitogenesis and Is …
- Genetic analysis of a Phosphatidylinositol 3–kinase SH2 domain reveals determinants of specificity
- Interleukin-10 stimulation of Phosphatidylinositol 3–kinase and p70 S6 kinase is required for the proliferative but not the antiinflammatory effects of the cytokine
- Heregulin Stimulates Mitogenesis and Phosphatidylinositol 3–kinase in Mouse Fibroblasts Transfected with erbB2/neu and erbB3 (∗)
- Phosphatidylinositol–3–kinase in isolated rat adipocytes. Activation by insulin and subcellular distribution.
- A Phosphatidylinositol 3–kinase is induced during soybean nodule organogenesis and is associated with membrane proliferation.
- A role for Phosphatidylinositol 3–kinase in the regulation of beta 1 integrin activity by the CD2 antigen.
- Association of Phosphatidylinositol 3–kinase with a specific sequence of the T cell receptor zeta chain is dependent on T cell activation.
- Interferon-α Engages the Insulin Receptor Substrate-1 to Associate with the Phosphatidylinositol 3′-kinase (∗)
- Platelet-derived growth factor-dependent activation of Phosphatidylinositol 3–kinase is regulated by receptor binding of SH2-domain-containing proteins which …
- Activation of Mitogen-activated Protein kinase and Phosphatidylinositol 3′-kinase Is Not Sufficient for the Hormonal Stimulation of Glucose Uptake …
- … through CD19 activates Vav/mitogen-activated protein kinase pathway and induces formation of a CD19/Vav/Phosphatidylinositol 3–kinase complex in human B cell …
- Novel functions of Phosphatidylinositol 3–kinase in terminally differentiated cells
- Phosphatidylinositol 3–kinase p85 SH2 domain specificity defined by direct phosphopeptide/SH2 domain binding
- Activation of the zeta isozyme of protein kinase C by Phosphatidylinositol 3, 4, 5-trisphosphate.
- … Mitogen-activated Protein kinase Activation by Platelet-activating Factor through a Mechanism Independent of p85/p110-type Phosphatidylinositol 3–kinase …
- Phosphatidylinositol 3–kinase and p70 s6 kinase participate in the regulation of protein turnover in skeletal muscle by insulin and insulin-like growth factor I
- Specific association of the β isoform of the p85 subunit of Phosphatidylinositol–3 kinase with the proto-oncogene c-cbl
- Insulin-mediated Targeting of Phosphatidylinositol 3–kinase to GLUT4-containing Vesicles (∗)
- HGF-mediated chemotaxis and tubulogenesis require activation of the Phosphatidylinositol 3–kinase
- CD28-mediated costimulation in the absence of Phosphatidylinositol 3–kinase association and activation
- Phosphatidylinositol 3–kinase functions upstream of Ras and Raf in mediating insulin stimulation of c-fos transcription
- Expression and characterization of the p85 subunit of the Phosphatidylinositol 3–kinase complex and a related p85β protein by using the baculovirus expression …
- Involvement of Phosphatidylinositol 3–kinase in the activation of extracellular signal-regulated kinase by PDGF in hepatic stellate cells
- Two Distinct Intracytoplasmic Regions of the T-cell Adhesion Molecule CD28 Participate in Phosphatidylinositol 3–kinase Association (∗)
- Receptor tyrosine kinase stimulates cell-matrix adhesion by Phosphatidylinositol 3 kinase and phospholipase C-gamma 1 pathways
- CD28 delivers costimulatory signals independently of its association with Phosphatidylinositol 3–kinase.
- Thrombin-dependent association of Phosphatidylinositol–3 kinase with p60c-src and p59fyn in human platelets
- Polyoma virus middle T antigen-pp60c-src complex associates with purified Phosphatidylinositol 3–kinase in vitro.
- ARIA/HRG regulates AChR epsilon subunit gene expression at the neuromuscular synapse via activation of Phosphatidylinositol 3–kinase and Ras/MAPK pathway.
- Brush Border Phosphatidylinositol 3–kinase Mediates Epidermal Growth Factor Stimulation of Intestinal NaCl Absorption and Na+/H+ Exchange (∗)
- Interaction of the Flt-1 Tyrosine kinase Receptor with the p85 Subunit of Phosphatidylinositol 3–kinase: MAPPING OF A NOVEL SITE INVOLVED IN BINDING …
- Activation of Phosphatidylinositol–3 kinase by ligation of the interleukin-7 receptor is dependent on protein tyrosine kinase activity
- … receptor activation of Phosphatidylinositol 3–kinase. von Willebrand factor stimulates the cytoskeletal association and activation of Phosphatidylinositol 3–kinase and …
- Fc receptor stimulation of Phosphatidylinositol 3–kinase in natural killer cells is associated with protein kinase C-independent granule release and cell-mediated …
- The C-terminal SH2 domain of p85 accounts for the high affinity and specificity of the binding of Phosphatidylinositol 3–kinase to phosphorylated platelet-derived …
- Interleukin‐7 induces the association of Phosphatidylinositol 3‐kinase with the α chain of the interleukin‐7 receptor
- A biosensor approach to probe the structure and function of the p85 alpha subunit of the Phosphatidylinositol 3–kinase complex
- ADP-ribosylation of rho p21 inhibits lysophosphatidic acid-induced protein tyrosine phosphorylation and Phosphatidylinositol 3–kinase activation in cultured …
- Activation of Phosphatidylinositol 3–kinase by epidermal growth factor, basic fibroblast growth factor, and nerve growth factor in PC12 pheochromocytoma cells.
- Insulin Stimulates Phosphatidylinositol‐3‐kinase activity in rat adipocytes
- Wortmannin binds specifically to 1-Phosphatidylinositol 3–kinase while inhibiting guanine nucleotide-binding protein-coupled receptor signaling in neutrophil …
- Erythropoietin-dependent association of Phosphatidylinositol 3–kinase with tyrosine-phosphorylated erythropoietin receptor.
- The colony stimulating factor-1 receptor associates with and activates Phosphatidylinositol–3 kinase
- Phosphatidylinositol–3 kinase and growth regulation
- Divergent regulation of Phosphatidylinositol 3–kinase P85 alpha and P85 beta isoforms upon T cell activation
- Insulin receptor substrate 1 binds two novel splice variants of the regulatory subunit of Phosphatidylinositol 3–kinase in muscle and brain
- Tumor Necrosis Factor Promotes Phosphorylation and Binding of Insulin Receptor Substrate 1 to Phosphatidylinositol 3–kinase in 3T3-L1 Adipocytes (∗)
- A region of the 85-kilodalton (kDa) subunit of Phosphatidylinositol 3–kinase binds the 110-kDa catalytic subunit in vivo
- Phosphatidylinositol 3–kinase acts at an intracellular membrane site to enhance GLUT4 exocytosis in 3T3-L1 cells
- Functional association of CD7 with Phosphatidylinositol 3–kinase: interaction via a YEDM motif
- Roles of 1-Phosphatidylinositol 3–kinase and ras in regulating translocation of GLUT4 in transfected rat adipose cells
- … within the alpha platelet-derived growth factor receptor kinase insert domain abrogate receptor-associated Phosphatidylinositol–3 kinase activity without affecting …
- Nuclear translocation of Phosphatidylinositol 3–kinase in rat pheochromocytoma PC 12 cells after treatment with nerve growth factor.
- Association of phosphorylated insulin-like growth factor-I receptor with the SH2 domains of Phosphatidylinositol 3–kinase p85.
- Phosphatidylinositol 3–kinase activity is required for hepatocyte growth factor-induced mitogenic signals in epithelial cells
- The insulin and insulin-like growth factor-I receptor substrate IRS-1 associates with and activates Phosphatidylinositol 3–kinase in vitro.
- An inhibitory role for Phosphatidylinositol 3–kinase in insulin secretion from pancreatic B cell line MIN6
- Rapid turnover of Phosphatidylinositol 3-phosphate in the green alga Chlamydomonas eugametos: signs of a phosphatidylinositide 3–kinase signalling pathway in …
- Ionizing Radiation Stimulates a Grb2-mediated Association of the Stress-activated Protein kinase with Phosphatidylinositol 3–kinase (∗)
- Essential role of Phosphatidylinositol 3‐kinase in insulin‐induced activation and phosphorylation of the cGMP‐inhibited cAMP phosphodiesterase in rat adipocytes …
- Inhibition of Phosphatidylinositol 3‐kinase blocks T cell antigen receptor/CD3‐induced activation of the mitogen‐activated kinase Erk2
- Insulin receptor substrate-1 mediates Phosphatidylinositol 3‘-kinase and p70S6k signaling during insulin, insulin-like growth factor-1, and interleukin-4 stimulation.
- Purification and characterization of a Phosphatidylinositol 3–kinase complex from bovine brain by using phosphopeptide affinity columns
- Association of the p85 regulatory subunit of Phosphatidylinositol 3–kinase with an essential erythropoietin receptor subdomain
- The cytoplasmic domain of CD28 is both necessary and sufficient for costimulation of interleukin-2 secretion and association with Phosphatidylinositol 3‘-kinase
- A Novel 55-kDa Regulatory Subunit for Phosphatidylinositol 3–kinase Structurally Similar to p55PIK Is Generated by Alternative Splicing of the p85α Gene (∗)
- The Phosphatidylinositol 3–kinase inhibitor wortmannin blocks mast cell exocytosis but not IL-6 production.
- In vivo binding properties of SH2 domains from GTPase-activating protein and Phosphatidylinositol 3–kinase
- … . Rapid induction of tyrosine phosphorylation, activation of syk tyrosine kinase, and phosphorylation of phospholipase C-gamma and Phosphatidylinositol 3–kinase.
- Wortmannin, a potent inhibitor of Phosphatidylinositol 3–kinase, inhibits osteoclastic bone resorption in vitro
- Structure and function of Phosphatidylinositol 3–kinase: a potential second messenger system involved in growth control
- Role of Phosphatidylinositol 3-OH-kinase activity in the inhibition of apoptosis in haemopoietic cells: Phosphatidylinositol 3-OH-kinase inhibitors reveal a difference in …
- Biochemical and pharmacological studies with KT7692 and LY294002 on the role of Phosphatidylinositol 3–kinase in FcεRI-mediated signal transduction
- The SH3 domain of p56lck is involved in binding to Phosphatidylinositol 3‘-kinase from T lymphocytes
- Activation of Phosphatidylinositol 3–kinase by prolactin in Nb2 cells
- Selective inhibition of p70 S6 kinase activation by Phosphatidylinositol 3‐kinase inhibitors
- Expression of Dominant Negative Mutant SHPTP2 Attenuates Phosphatidylinositol 3′-kinase Activity via Modulation of Phosphorylation of Insulin Receptor …
- Src-homology 3 domain of protein kinase p59fyn mediates binding to Phosphatidylinositol 3–kinase in T cells.
- Effect of the Activation of Phosphatidylinositol 3–kinase by a Thiophosphotyrosine Peptide on Glucose Transport in 3T3-L1 Adipocytes (∗)
- A mutational analysis of Phosphatidylinositol–3–kinase activation by human colony-stimulating factor-1 receptor
- Phosphatidylinositol–3 kinase is activated in v-src, v-yes, and v-fps transformed chicken embryo fibroblasts.
- Insulin-mediated inhibition of apolipoprotein B secretion requires an intracellular trafficking event and Phosphatidylinositol 3–kinase activation: studies with brefeldin A …
- Phosphatidylinositol 3–kinase, but Not p70/p85 Ribosomal S6 Protein kinase, Is Required for the Regulation of Phosphoenolpyruvate Carboxykinase …
- Activation of Phosphatidylinositol‐3‐kinase in Jurkat T cells depends on the presence of the p56lck tyrosine kinase
- Embryonic mesoderm cells spread in response to platelet-derived growth factor and signaling by Phosphatidylinositol 3–kinase.
- Inhibition of the signalling enzyme Phosphatidylinositol–3–kinase by antitumor ether lipid analogues
- Formation of c-Cbl· Phosphatidylinositol 3–kinase Complexes on Lymphocyte Membranes by a p56lck-independent Mechanism
- Activation of protein kinase C by Phosphatidylinositol 3, 4, 5-trisphosphate
- Activation of Phosphatidylinositol–3 kinase by ligation of the interleukin-7 receptor on human thymocytes.
- T Cell Activation-dependent Association between the p85 Subunit of the Phosphatidylinositol 3–kinase and Grb2/Phospholipase C-γ1-binding Phosphotyrosyl …
- Phosphatidylinositol 3–kinase-independent signal transduction pathway for platelet-derived growth factor-induced chemotaxis
- Microinjection of the SH2 domain of the 85-kilodalton subunit of Phosphatidylinositol 3–kinase inhibits insulin-induced DNA synthesis and c-fos expression
- Phosphatidylinositol 3–kinase activity is important for progesterone-induced Xenopus oocyte maturation
- Phosphatidylinositol 3–kinase is necessary and sufficient for insulin-stimulated stress fiber breakdown
- Interleukin-2 receptor regulates activation of Phosphatidylinositol 3–kinase
- … interact with the effector molecules phospholipase C-gamma 2, microtubule-associated protein kinase, GTPase-activating protein, and Phosphatidylinositol 3–kinase
- The Src-family kinase, Fyn, regulates the activation of Phosphatidylinositol 3–kinase in an interleukin 2-responsive T cell line.
- Insulin like growth factor-I induces limited association of Phosphatidylinositol 3–kinase to its receptor.
- Requirement for Phosphatidylinositol 3′-kinase Activity in Platelet-derived Growth Factor-stimulated Tyrosine Phosphorylation of p125 Focal Adhesion …
- PDGF-mediated activation of Phosphatidylinositol 3 kinase in human mesangial cells
- Direct association of p110 beta Phosphatidylinositol 3–kinase with p85 is mediated by an N-terminal fragment of p110 beta
- JAK3 protein tyrosine kinase mediates interleukin-7-induced activation of Phosphatidylinositol–3‘kinase
- Activation of Phosphatidylinositol–3 kinase by nerve growth factor involves indirect coupling of the trk proto-oncogene with src homology 2 domains
- … Receptor Stimulation and Interacts in Vivo with Fyn and Syk Tyrosine kinases, Grb2 and Shc Adaptors, and the p85 Subunit of Phosphatidylinositol 3–kinase …
- Signal transduction in neutrophil activation Phosphatidylinositol 3‐kinase is stimulated without tyrosine phosphorylation
- Insulin receptor substrate 1 is phosphorylated by the serine kinase activity of Phosphatidylinositol 3–kinase
- Different Effects of Insulin and Platelet‐Derived Growth Factor on Phosphatidylinositol 3‐kinase at the Subcellular Level in 3T3‐L1 Adipocytes: A Possible Explanation …
- … translation initiation factor 4E phosphorylation, and PHAS-I phosphorylation by insulin requires insulin receptor substrate 1 and Phosphatidylinositol 3–kinase
- A multiwell assay for inhibitors of Phosphatidylinositol–3–kinase and the identification of natural product inhibitors.
- Physiologic Levels of β‐Amyloid Activate Phosphatidylinositol 3‐kinase with the Involvement of Tyrosine Phosphorylation
- Regulation of Phosphatidylinositol 3–kinase by insulin in rat skeletal muscle
- … p120: demonstration of its identity with the c-cbl protooncogene product and in vivo complexes with Fyn, Grb2, and Phosphatidylinositol 3–kinase
- Evidence for a role of Phosphatidylinositol 3–kinase in the regulation of glucose transport in Xenopus oocytes.
- … Stimulates the Tyrosine Phosphorylation of the Insulin Receptor Substrate-1 and Its Association with Phosphatidylinositol 3–kinase in Primary Adipocytes (∗)
- Modification of the 85-kilodalton subunit of Phosphatidylinositol–3 kinase in platelet-derived growth factor-stimulated cells
- Regulation of insulin receptor, insulin receptor substrate-1 and Phosphatidylinositol 3–kinase in 3T3-F442A adipocytes. Effects of differentiation, insulin, and …
- IL-2 binding activates a tyrosine-phosphorylated Phosphatidylinositol–3–kinase.
- Phosphatidylinositol 3–kinase and the actin network are not required for the stimulation of glucose transport caused by mitochondrial uncoupling: comparison with …
- Extracellular human immunodeficiency virus type-1 Tat protein activates Phosphatidylinositol 3–kinase in PC12 neuronal cells
- Evidence that protein tyrosine kinase p56-Lck regulates the activity of Phosphatidylinositol–3‘-kinase in interleukin-2-dependent T-cells.
- Association of IRS-1 with the insulin receptor and the Phosphatidylinositol 3‘-kinase. Formation of binary and ternary signaling complexes in intact cells.
- Differential effects of okadaic acid on insulin-stimulated glucose and amino acid uptake and Phosphatidylinositol 3–kinase activity
- … a mitogen-activated protein kinase (ERK2) by the 5-hydroxytryptamine1A receptor is sensitive not only to inhibitors of Phosphatidylinositol 3–kinase, but to an …
- Association of Phosphatidylinositol 3–kinase, via the SH2 domains of p85, with focal adhesion kinase in polyoma middle t-transformed fibroblasts
- SH2-dependent association of Phosphatidylinositol 3‘-kinase 85-kDa regulatory subunit with the interleukin-2 receptor beta chain.
- Association between Phosphatidylinositol–3 kinase, Cbl and other tyrosine phosphorylated proteins in colony-stimulating factor-1-stimulated macrophages
- Phosphatidylinositol–3–kinase activity is required for the anti-Ig-mediated growth inhibition of a human B-lymphoma cell line
- Role of p85 subunit of Phosphatidylinositol–3–kinase as an adaptor molecule linking the insulin receptor, p62, and GTPase-activating protein.
- Interactions of polyomavirus middle T with the SH2 domains of the pp85 subunit of Phosphatidylinositol–3–kinase
- Association of activated Phosphatidylinositol 3–kinase with p120cbl in antigen receptor-ligated B cells
- The alpha-type 85-kDa subunit of Phosphatidylinositol 3–kinase is phosphorylated at tyrosines 368, 580, and 607 by the insulin receptor.
- Inhibition of Phosphatidylinositol–3′-kinase Prevents Induction of Endotoxin Tolerancein Vitro
- Synthesis and in Vitro Evaluation of New Wortmannin Esters: Potent Inhibitors of Phosphatidylinositol 3–kinase
- Schizosaccharomyces pombe Vps34p, a Phosphatidylinositol-specific PI 3–kinase essential for normal cell growth and vacuole morphology
- Effects of growth factors on Phosphatidylinositol‐3 kinase in astroglial cells
- … -like growth factor induces phosphorylation of immunoreactive insulin receptor substrate and its association with Phosphatidylinositol–3 kinase in human thymocytes.
- Phosphatidylinositol 3′‐kinase associates with p145c‐kit as part of a cell type characteristic multimeric signalling complex.
- The Phosphatidylinositol 3–kinase inhibitor, wortmannin, inhibits insulin-induced activation of phosphatidylcholine hydrolysis and associated protein kinase C …
- Characterization of the bovine brain cytosolic Phosphatidylinositol 3–kinase complex
- Phosphatidylinositol 3–kinase activity is required for the activation process of focal adhesion kinase by platelet-derived growth factor
- Structure of a specific peptide complex of the carboxy‐terminal SH2 domain from the p85 alpha subunit of Phosphatidylinositol 3‐kinase.
- … characterization of Lnk, a signal transduction protein that links T-cell receptor activation signal to phospholipase C gamma 1, Grb2, and Phosphatidylinositol 3–kinase.
- Specific activity of Phosphatidylinositol 3–kinase is increased by insulin stimulation
- Mutations in the juxtamembrane region of the insulin receptor impair activation of Phosphatidylinositol 3–kinase by insulin
- CD38-mediated growth suppression of B-cell progenitors requires activation of Phosphatidylinositol 3–kinase and involves its association with the protein product of …
- Signal transduction by the hepatocyte growth factor receptor, c-met. Activation of the Phosphatidylinositol 3–kinase.
- Transformation-defective mutants of polyomavirus middle T antigen associate with Phosphatidylinositol 3–kinase (PI 3–kinase) but are unable to maintain wild-type …
- Structural features of the colony‐stimulating factor 1 receptor that affect its association with Phosphatidylinositol 3‐kinase.
- Activation of Na+/H+ exchange by platelet-derived growth factor involves Phosphatidylinositol 3‘-kinase and phospholipase C gamma.
- Disruption of GLUT1 glucose carrier trafficking in L6E9 and Sol8 myoblasts by the Phosphatidylinositol 3–kinase inhibitor wortmannin
- Phosphatidylinositol–3 kinase in fission yeast: a possible role in stress responses
- Insulin-dependent formation of a complex containing an 85-kDa subunit of Phosphatidylinositol 3–kinase and tyrosine-phosphorylated insulin receptor …
- Regulation by insulin of Phosphatidylinositol 3‘-kinase bound to alpha-and beta-isoforms of p85 regulatory subunit.
- Herbimycin A inhibits the association of p60v-src with the cytoskeletal structure and with Phosphatidylinositol 3‘kinase.
- Novel quinone antiproliferative inhibitors of Phosphatidylinositol–3–kinase.
- … and insulin-like growth factor-I actions in the bovine luteal cell: regulation of receptor tyrosine kinase activity, Phosphatidylinositol–3–kinase, and deoxyribonucleic acid …
- Oncostatin M activates Phosphatidylinositol–3–kinase in Kaposi’s sarcoma cells.
- Interleukin 2-and polyomavirus middle T antigen-induced modification of Phosphatidylinositol 3–kinase activity in activated T lymphocytes
- Erythropoietin induces the association of Phosphatidylinositol 3′‐kinase with a tyrosine‐phosphorylated protein complex containing the erythropoietin receptor
- Activation of pp70/85 S6 kinases in interleukin-2-responsive lymphoid cells is mediated by Phosphatidylinositol 3–kinase and inhibited by cyclic AMP
- In vitro association of Phosphatidylinositol 3–kinase activity with the activated insulin receptor tyrosine kinase.
- Phosphatidylinositol 3‐kinase activity is not essential for CD28 costimulatory activity in Jurkat T cells: studies with a selective inhibitor, wortmannin
- Effect of epidermal growth factor on Phosphatidylinositol 3–kinase activity in rabbit corneal epithelial cells
- Insulin-stimulated Phosphatidylinositol 3–kinase activity and 2-deoxy-D-glucose uptake in rat skeletal muscles
- Activation and nuclear translocation of mitogen-activated protein kinases by polyomavirus middle-T or serum depend on Phosphatidylinositol 3–kinase
- Localization of mRNA for Phosphatidylinositol 3–kinase in brain of developing and mature rats
- Phosphatidylinositol 3–kinase inhibitor, wortmannin, inhibits 5-hydroxytryptamine-mediated potentiation of platelet aggregation induced by epinephrine.
- The human gene encoding Phosphatidylinositol–3 kinase associated p85α is at chromosome region 5q12–13
- Role of p85 subunit of Phosphatidylinositol–3–kinase as an adaptor molecule linking the insulin receptor to insulin receptor substrate 1.
- An 11-Amino Acid Sequence from c-met Initiates Epithelial Chemotaxis via Phosphatidylinositol 3–kinase and Phospholipase C (∗)
- Specific binding of Fyn and Phosphatidylinositol 3‐kinase to the B cell surface glycoprotein CD19 through their src homology 2 domains
- … Interfere with Chemoattractant-induced Respiratory Burst in Neutrophils as a Result of the Inhibition of Phosphatidylinositol 3–kinase Rather than Receptor …
- Differential effects of spermine on Phosphatidylinositol 3–kinase and Phosphatidylinositol phosphate 5-kinase
- Angiotensin II induces tyrosine phosphorylation of insulin receptor substrate 1 and its association with Phosphatidylinositol 3–kinase in rat heart
- Cooperation of Src homology domains in the regulated binding of Phosphatidylinositol 3–kinase: a role for the Src homology 2 domain
- Evidence for a role of Phosphatidylinositol 3–kinase in IL-4-induced germline Cϵ transcription
- Lovastatin inhibits platelet-derived growth factor (PDGF) stimulation of Phosphatidylinositol 3–kinase activity as well as association of p85 subunit to tyrosine …
- Hepatocyte growth factor-induced proliferation of primary hepatocytes is mediated by activation of Phosphatidylinositol 3–kinase
- Platelet-derived growth factor activates membrane-associated Phosphatidylinositol 3–kinase and mediates its translocation from the cytosol. Detection of …
- Mutations in the SH3 domain of the src oncogene which decrease association of Phosphatidylinositol 3‘-kinase activity with pp60v-src and alter cellular morphology
- T cell receptor-associated alpha-Phosphatidylinositol 3–kinase becomes activated by T cell receptor cross-linking and requires pp56lck.
- … of the free catalytic p110 alpha and the complexed heterodimeric p110 alpha. p85 alpha forms of the mammalian Phosphatidylinositol 3–kinase.
- Translocation, Activation and Association of Protein‐tyrosine kinase (p72syk) with Phosphatidylinositol 3‐kinase are Early Events During Platelet Activation
- Molecular cloning of an amphibian insulin receptor substrate 1-like cDNA and involvement of Phosphatidylinositol 3–kinase in insulin-induced Xenopus oocyte …
- … colony-stimulating factor, but not IL-4, induce tyrosine phosphorylation, activation, and association of SHPTP2 with Grb2 and Phosphatidylinositol 3‘-kinase.
- Thrombin-stimulated immunoprecipitation of Phosphatidylinositol 3–kinase from human platelets.
- Regulation of phosphoinositide kinases in T cells. Evidence that Phosphatidylinositol 3–kinase is not a substrate for T cell antigen receptor-regulated tyrosine …
- Both CD28 ligands CD80 (B7-1) and CD86 (B7-2) activate Phosphatidylinositol 3–kinase, and wortmannin reveals heterogeneity in the regulation of T cell IL-2 …
- Enhanced gene expression for Phosphatidylinositol 3–kinase in the hypoglossal motoneurons following axonal crush
- Phosphatidylinositol 3–kinase
- Agonist-induced association of the p21rasGTPase-activating protein with Phosphatidylinositol 3–kinase
- Insulin induces a change in Rab5 subcellular localization in adipocytes independently of Phosphatidylinositol 3–kinase activation
- Cytoplasmic and nuclear localization sites of Phosphatidylinositol 3–kinase in human osteosarcoma sensitive and multidrug-resistant Saos-2 cells
- Functional interactions of Phosphatidylinositol 3–kinase with GTPase-activating protein in 3T3-L1 adipocytes
- Phosphatidylinositol–3′ kinase is not required for mitogenesis or internalization of the Flt3/Flk2 receptor tyrosine kinase
- … a cysteine residue in polyomavirus middle T antigen abolishes interactions with protein phosphatase 2A, pp60c-src, and Phosphatidylinositol–3 kinase, activation of c …
- Potent activation of Phosphatidylinositol 3‘-kinase by simple phosphotyrosine peptides derived from insulin receptor substrate 1 containing two YMXM motifs for …
- The insulin-elicited 60-kDa phosphotyrosine protein in rat adipocytes is associated with Phosphatidylinositol 3–kinase.
- Specific association of Phosphatidylinositol 3‐kinase with the protooncogene product Cbl in Fcγ receptor signaling
- Insulin and dexamethasone regulate insulin receptors, insulin receptor substrate-1, and Phosphatidylinositol 3–kinase in Fao hepatoma cells
- Phosphatidylinositol 3–kinase activity in murine erythroleukemia cells during DMSO-induced differentiation
- Activation of Src-family protein tyrosine kinases and Phosphatidylinositol 3–kinase in 3T3-L1 mouse preadipocytes by interleukin-11.
- The level of insulin receptor tyrosine kinase activity modulates the activities of Phosphatidylinositol 3–kinase, microtubule-associated protein, and S6 kinases.
- Wortmannin inhibits insulin secretion in pancreatic islets and β-TC3 cells independent of its inhibition of Phosphatidylinositol 3–kinase
- … derived growth factor triggers translocation of the insulin-regulatable glucose transporter (type 4) predominantly through Phosphatidylinositol 3–kinase binding sites on …
- Induction of activator protein (AP)-1 and nuclear factor-kappaB by CD28 stimulation involves both Phosphatidylinositol 3–kinase and acidic sphingomyelinase signals.
- CD28-mediated up-regulation of beta 1-integrin adhesion involves Phosphatidylinositol 3–kinase.
- The HIV-1 Nef Protein Interferes with Phosphatidylinositol 3–kinase Activation 1 (∗)
- Monocyte Colony-stimulating Factor Stimulates Binding of Phosphatidylinositol 3–kinase to Grb2· Sos Complexes in Human Monocytes
- The protein product of the proto-oncogene c-cbl forms a complex with Phosphatidylinositol 3–kinase p85 and CD19 in anti-IgM-stimulated human B-lymphoma …
- Potentiation of insulin stimulation of Phosphatidylinositol 3–kinase by thiazolidinedione-derived antidiabetic agents in Chinese hamster ovary cells expressing human …
- Modulation of the substrate specificity of the mammalian Phosphatidylinositol 3–kinase by cholesterol sulfate and sulfatide
- Insulin-stimulated oocyte maturation requires insulin receptor substrate 1 and interaction with the SH2 domains of Phosphatidylinositol 3–kinase
- Involvement of Phosphatidylinositol 3–kinase in stimulation of glucose transport by growth factors in 3T3-L1 adipocytes.
- 17β-hydroxywortmannin: A potent inhibitor of bone resorption and Phosphatidylinositol–3–kinase
- Activation of Phosphatidylinositol–3–kinase by platelet-derived growth factor and insulin-like growth factor-1 is inhibited by a transmembrane phosphotyrosine …
- CD28-mediated cytotoxicity by the human leukemic NK cell line YT involves tyrosine phosphorylation, activation of Phosphatidylinositol 3–kinase, and protein kinase C …
- Association of Phosphatidylinositol 3 kinase to protein kinase C ζ during interleukin‐2 stimulation
- Interaction of the molecular weight 85K regulatory subunit of the Phosphatidylinositol 3–kinase with the insulin receptor and the insulin-like growth factor-1 (IGF-I) …
- A tyrosine kinase signaling pathway accounts for the majority of Phosphatidylinositol 3, 4, 5-trisphosphate formation in chemoattractant-stimulated human …
- Phorbol ester treatment inhibits Phosphatidylinositol 3–kinase activation by, and association with, CD28, a T-lymphocyte surface receptor.
- Chromosomal localization of human p85 alpha, a subunit of Phosphatidylinositol 3–kinase, and its homologue p85 beta.
- Phosphatidylinositol 3′-kinase, but not p70 ribosomal S6 kinase, is involved in membrane protein recycling: wortmannin inhibits glucose transport and …
- Gastrin stimulates tyrosine phosphorylation of insulin receptor substrate 1 and its association with Grb2 and the Phosphatidylinositol 3–kinase
- Identification of amino acid residues required for a specific interaction between Src-tyrosine kinase and proline-rich region of Phosphatidylinositol–3′ kinase
- Studies with wortmannin suggest a role for Phosphatidylinositol 3–kinase in the activation of glycogen synthase and mitogen-activated protein kinase by insulin in rat …
- Insulin treatment stimulates the tyrosine phosphorylation of the alpha-type 85-kDa subunit of Phosphatidylinositol 3–kinase in vivo.
- NMR Analysis of Interactions of a Phosphatidylinositol 3 ‘-kinase SH2 Domain with Phosphotyrosine Peptides Reveals Interdependence of Major Binding Sites
- Endotoxin tolerance alters phospholipase C-γ1 and Phosphatidylinositol–3′-kinase expression in peritoneal macrophages
- … cytoplasmic domain of the interleukin-2 receptor beta chain is essential for interleukin-2-dependent tyrosine protein kinase and Phosphatidylinositol–3–kinase …
- Phosphatidylinositol–3–kinase is a non-tyrosine phosphorylated member of the insulin receptor signalling complex
- Activation of Phosphatidylinositol–3–kinase by insulin is mediated by both A and B human insulin receptor types
- CD28 co-stimulatory regimes differ in their dependence on Phosphatidylinositol 3–kinase: common co-signals induced by CD80 and CD86
- Naturally occurring ether‐linked phosphatidylcholine activates Phosphatidylinositol 3‐kinase and stimulates cell growth
- … colony-stimulating factor 1 receptor impairs mitogenesis without abrogating tyrosine kinase activity, association with Phosphatidylinositol 3–kinase, or induction of c …
- Interleukin-4 induces association of the c-fes proto-oncogene product with Phosphatidylinositol–3 kinase
- Cyclic peptide inhibitors of Phosphatidylinositol 3–kinase p85 SH2 domain binding
- Studies of partially transforming polyomavirus mutants establish a role for Phosphatidylinositol 3–kinase in activation of pp70 S6 kinase
- Lysophosphatidic acid stimulates glucose transport in Xenopus oocytes via a Phosphatidylinositol 3′-kinase with distinct properties
- Phosphatidylinositol 3-OH kinase activity is not required for activation of mitogen-activated protein kinase by cytokines
- Growth factor-regulated Phosphatidylinositol–3–kinase in astrocytes. Involvement of pp60c-Src.
- Selective inhibition of Phosphatidylinositol 3–kinase by phosphatidic acid and related lipids
- Evidence of the Involvement of Phosphatidylinositol 3–kinase in the Migration, Actin Stress Fiber Formation, and αvβ3-Integrin–Mediated Adherence of Human …
- The effects of wortmannin, a potent inhibitor of Phosphatidylinositol 3–kinase, on insulin-stimulated glucose transport, GLUT4 translocation, antilipolysis, and DNA …
- Phosphatidylinositol 3–kinase binding to polyoma virus middle tumor antigen mediates elevation of glucose transport by increasing translocation of the GLUT1 …
- Phosphatidylinositol 3–kinase participates in p56 (lck)/CD4-dependent down-regulation of LFA-1-mediated T cell adhesion.
- Wortmannin, a specific inhibitor of Phosphatidylinositol–3–kinase, inhibits erythropoietin-induced erythroid differentiation of K562 cells.
- Interleukin-4 (IL-4) induces protein tyrosine phosphorylation of the IL-4 receptor and association of Phosphatidylinositol 3–kinase to the IL-4 receptor in a mouse T cell …
- Mammalian Phosphatidylinositol 3′‐kinase induces a lethal phenotype on expression in Schizosaccharomyces pombe; comparison with the VPS34 gene product
- A role for Phosphatidylinositol 3–kinase in generating T cell help for B cell growth and differentiation.
- Insulin Stimulates Phosphatidylinositol 3‐kinase Activity in Rat Neuronal Primary Cultures
- Comparison of CD28‐B7. 1 and B7. 2 functional interaction in resting human T cells: Phosphatidylinositol 3‐kinase association to CD28 and cytokine production
- Tyrosine 508 of the 85-kilodalton subunit of Phosphatidylinositol 3–kinase is phosphorylated by the platelet-derived growth factor receptor
- Interleukin 7 receptor mediates the activation of Phosphatidylinositol–3 kinase in human B-cell precursors
- Association of Phosphatidylinositol 3‐kinase with the photo‐oncogene product Cbl upon CD38 ligation by a specific monoclonal antibody in THP‐1 cells
- Regulation of CD4-p561ck-associated Phosphatidylinositol 3–kinase (PI 3–kinase) and Phosphatidylinositol 4-kinase (PI 4-kinase)
- … in downstream signaling pathways of p185BCR-ABL in Ph+ ALL involve GTPase-activating protein, phospholipase C-gamma 1, and Phosphatidylinositol 3‘-kinase.
- … That Signals DNA Synthesis in NIH 3T3 Cells Specifically Binds a Complex of Src and Janus Family Tyrosine kinases and Phosphatidylinositol 3–kinase (∗)
- Anti-phosphotyrosine immunoprecipitation of Phosphatidylinositol 3′ kinase activity in different cell types after exposure to epidermal growth factor
- … B cell antigen receptor-related structure of pre-B cell lines induces tyrosine phosphorylation of p85 and p110 subunits and activation of Phosphatidylinositol 3–kinase
- The Gene That Encodes the Phosphatidylinositol–3 kinase Regulatory Subunit (p85α) Maps to Chromosome 13 in the Mouse
- The catalytic subunit of Phosphatidylinositol 3–kinase is a substrate for the activated platelet-derived growth factor receptor, but not for middle-T antigen-pp60c-src …
- Phosphatidylinositol 3 kinase activity is not essential for B7-1-mediated costimulation of proliferation or development of cytotoxicity in murine T cells.
- Effects of phorbol esters on insulin‐induced activation of Phosphatidylinositol 3‐kinase, glucose transport, and glycogen synthase in rat adipocytes
- The E5 gene product of rhesus papillomavirus is an activator of endogenous Ras and Phosphatidylinositol–3′-kinase in NIH 3T3 cells
- … by mutation of the tyrosine residues in the insulin receptor substrate-1 affecting association with the tyrosine phosphatase 2C and Phosphatidylinositol 3–kinase
- … site mutants in the murine colony-stimulating factor-1 receptor are unaffected in their ability to bind or phosphorylate Phosphatidylinositol–3 kinase but show differential …
- Insulin-like growth factor-1 stimulation of cells induces formation of complexes containing Phosphatidylinositol–3–kinase, guanosine triphosphatase-activating protein …
- Phosphatidylinositol 3–kinase
- Vps34p required for yeast vacuolar protein sorting is a multiple specificity kinase that exhibits both protein kinase and Phosphatidylinositol-specific PI 3–kinase …
- Wortmannin-mediated inhibition of Phosphatidylinositol 3–kinase activity triggers apoptosis in normal and neoplastic B lymphocytes which are in cell cycle
- … in 32D cells requires insulin receptor, Shc, and mitogen-activated protein kinase, but not insulin receptor substrate-1 and Phosphatidylinositol 3–kinase …
- … exerts a full insulin-like effect on glucose transport and glucose transporter 4 translocation in human adipocytes: evidence for a Phosphatidylinositol 3–kinase …
- Phosphatidylinositol 3–kinase: inhibition of intrinsic protein-serine kinase activity by phosphoinositides, and of lipid kinase activity by Mn2+
- Alternative binding of p56lck and Phosphatidylinositol 3–kinase in T cells by sulfhydryl oxidation: implication of aberrant signaling due to oxidative stress in T …
- Effect of IGF-I on Phosphatidylinositol 3–kinase in soleus muscle of lean and insulin-resistant obese mice
- Activation of Phosphatidylinositol 3–kinase and Phosphatidylinositol 4-kinase during rat parotid acinar cell proliferation
- A product of Phosphatidylinositol–3 kinase is elevated in dividing HT29 colonic epithelial cells
- Phosphorylation in vitro of the 85 kDa subunit of Phosphatidylinositol 3–kinase and its possible activation by insulin receptor tyrosine kinase
- Structure-activity studies of phosphorylated peptide inhibitors of the association of Phosphatidylinositol 3–kinase with PDGF-β receptor
- Mitogenic inhibition by phorbol esters is associated with decreased Phosphatidylinositol–3 kinase activation
- Structure of 85 kDa subunit of human Phosphatidylinositol 3‐kinase analyzed by using monoclonal antibodies
- Activation of Phosphatidylinositol 3–kinase by concanavalin A through dual signaling pathways, G-protein-coupled and phosphotyrosine-related, and an essential role …
- Rapid and efficient purification of Src homology 2 domain-containing proteins: Fyn, Csk and Phosphatidylinositol 3–kinase p85
- Activation of Akt by nerve growth factor via Phosphatidylinositol–3 kinase in PC12 pheochromocytoma cells
- SH3 domain-mediated dimerization of an n-terminal fragment of the Phosphatidylinositol 3–kinase p85 subunit
- EFFECT OF LOVASTATIN AND FLUOROMEVALONATE ON Phosphatidylinositol 3‐kinase ACTIVITY STIMULATED WITH PDGF
- … factor induces the tyrosine phosphorylation and activation of phospholipase C-gamma 1, Fyn and Lyn kinases, and Phosphatidylinositol 3–kinase in a human B cell …
- Protein kinase C-mediated formation of Phosphatidylinositol 3, 4-bisphosphate in human platelets
- EJ-Ras Inhibits Phospholipase Cγ1 but Not Actin Polymerization Induced by Platelet-Derived Growth Factor-BB via Phosphatidylinositol 3–kinase
- Controlled overexpression of selected domains of the P85 subunit of Phosphatidylinositol 3–kinase reverts v-Ha-Ras transformation
- Insulin-like growth factor-1-mediated association of p85 Phosphatidylinositol 3–kinase with pp 185: requirement of SH2 domains for in vivo interaction.
- The differential activation of Phosphatidylinositol–3 kinase and mitogen-activated protein kinases by PDGF-AA and IGF-I might explain the synergistic effect of the two …
- CD28‐dependent killing by human YT cells requires Phosphatidylinositol 3‐kinase activation
- Phosphoinositide 3-phosphatase segregates from Phosphatidylinositol 3–kinase in EGF-stimulated A431 cells and fails to in vitro hydrolyse Phosphatidylinositol (3, 4 …
- … p21ras-mediated signaling is independent of platelet-derived growth factor receptor interaction with GTPase-activating protein or Phosphatidylinositol–3–kinase.
- Synthesis of Phosphatidylinositol 3, 4-bisphosphate is regulated by protein-tyrosine phosphorylation but the p85α subunit of Phosphatidylinositol 3–kinase may not be …
- Peptide antisera to human colony-stimulating factor 1 receptor detect ligand-induced conformational changes and a binding site for Phosphatidylinositol 3–kinase
- Inhibition of IGF II-induced redistribution of mannose 6-phosphate receptors by the Phosphatidylinositol 3–kinase inhibitor, wortmannin
- A novel pathway for the formation of Phosphatidylinositol 3, 4-bisphosphate. Phosphorylation of Phosphatidylinositol 3-monophosphate by …
- Novel protein kinase/Phosphatidylinositol 3–kinase complex essential for receptor-mediated protein sorting to the vacuole in yeast
- Haematopoietic colony stimulating factors CSF-1 and GM-CSF increase Phosphatidylinositol 3–kinase activity in murine bone marrow-derived macrophages
- Isolation of the active form of RAC‐protein kinase (PKB/Akt) from transfected COS‐7 cells treated with heat shock stress and effects of Phosphatidylinositol 3, 4, 5 …
- Association of the insulin receptor and Phosphatidylinositol 3–kinase requires a third component
- Interleukin-4 activates two distinct pathways of Phosphatidylinositol–3 kinase in the same cells
- Dominant negative effect of the truncated p110 subunit of Phosphatidylinositol‐3 kinase
- … FTI-244 decreases platelet-derived growth factor receptor tyrosine phosphorylation levels and inhibits stimulation of Phosphatidylinositol 3–kinase but not mitogen …
- Inhibition of Neuroblastoma Cell Phosphatidylinositol 3‐kinase by CDP‐Diacylglycerol and Phosphatidate
- Regulation of Phosphatidylinositol–3 kinase by tyrosyl phosphoproteins
- D-myo-Inositol 1, 4, 5-trisphosphate analogues modified at the 3-position inhibit Phosphatidylinositol 3–kinase
- Detection of a 60 kDa tyrosine-phosphorylated protein in insulin-stimulated hepatoma cells that associates with the SH2 domain of Phosphatidylinositol 3–kinase
- Serine-rich region of the IL-2 receptor β-chain is required for activation of Phosphatidylinositol 3–kinase
- In vitro association of the Phosphatidylinositol 3‐kinase regulatory subunit (p85) with the human insulin receptor
- Phosphatidylinositol 3–kinase is involved in TRE-dependent gene expression in response to arginine vasopressin
- Dissociation of Phosphatidylinositol–3 kinase activity and mitogenic inhibition in vascular smooth muscle cells
- … H2O2 and vanadate enhances insulin receptor mediated tyrosine phosphorylation of IRS‐1 leading to IRS‐1 association with the Phosphatidylinositol 3‐kinase
- Characterization of a Phosphatidylinositol-specific phosphoinositide 3–kinase from mammalian cells
- Insulin-dependent Phosphatidylinositol 3′-kinase activity co-precipitates with insulin receptor in human circulating mononuclear cells
- Phosphatidylinositol (PI) 3–kinase and PI 4-kinase binding to the CD4-p56lck complex: the p56lck SH3 domain binds to PI 3–kinase but not PI 4-kinase
- O-17: Overexpression of a constitutively active form of Phosphatidylinositol 3 kinase is sufficient to Promote GLUT 4 translocation in transfected rat adipose cells
- Platelet-Derived Growth Factor Induces Phosphatidylinositol 3–kinase Release from the Middle T-pp60c-src Complex and Association with the Platelet-Derived …
- Phosphatidylinositol 3–kinase: A Novel Signal Transduction Pathway?
- Up-regulation of Expression of Phosphatidylinositol 3–kinase in Psoriatic Lesions
- A Phosphatidylinositol (PI) kinase gene family in Dictyostelium discoideum: biological roles of putative mammalian p110 and yeast Vps34p PI 3–kinase homologs …
- Differential roles of Phosphatidylinositol 3–kinase in mitogen-activated prote in kinase activation by insulin and epidermal growth factor
- Production of monoclonal antibodies specific to the carboxyl terminal region of the 85 kDa subunit of Phosphatidylinositol 3‐kinase: Use of the antibodies in …
- Phosphatidylinositol 3–kinase is involved in the colony-stimulating factor-1-induced spreading of macrophages and osteoclasts.
- Purification of Phosphatidylinositol 3–kinase by SDS-agarose gel electrophoresis and HPEC
- Does Phosphatidylinositol 3‐kinase play a role in insulin‐induced outgrowth of pseudopodial cables in cultured cells derived from micromeres of sea urchin embryos?
- Phosphatidylinositol–3–kinase Pathway is Stimulated by Fungal Lipid Containing Cocoa Butter Equivalents (CBE) in FMet-Leu-Phe (FMLP)-and Phorbolester (PMA) …
- A structural and functional analysis of the Phosphatidylinositol 3–kinase
- Engagement of the osteoclast integrin alpha v beta 3 by osteopontin stimulates Phosphatidylinositol 3-hydroxyl kinase activity
- O-49: A prevalent amino acid polymorphism at codon 325Met-> IIe in the gene encoding the Phosphatidylinositol 3–kinase p85α regulatory subunit is associated with …
- Activation of PRK1 by Phosphatidylinositol 4, 5-Bisphosphate and Phosphatidylinositol 3, 4, 5-Trisphosphate: A COMPARISON WITH PROTEIN kinase C …
- Characterization of tyrosine kinase-associated Phosphatidylinositol–3 kinase.
- The experimental study on Phosphatidylinositol 3–kinase/Akt in neural stem cells in vitro
- Phosphatidylinositol 3–kinase activation by IGF-I is independent of irs-1 in hl-60 cells
- Role of Phosphatidylinositol 3–kinase in growth factor and oncogene signaling
- Purification and characterisation of Phosphatidylinositol 3–kinase from bovine brain
- CD19 and Phosphatidylinositol 3–kinase
- Activation of Phosphatidylinositol 3–kinase in hepatocyte growth and hepatocellular transformation
- Phosphatidylinositol 3–kinase (PI3k) is required for chemoattractant-stimulated homotypic aggregation of human neutropfflls
- Shear stress-induced signal transduction through Phosphatidylinositol–3 kinase in endothelial cells
- Early events in insulin signaling: Tyrosine phosphorylation and Phosphatidylinositol 3–kinase activation
- Profilin and gelsolin stimulate Phosphatidylinositol 3–kinase activity
- Phosphatidylinositol 3–kinase Activity in 3T3-L1 Adipocytes: Effects of Pioglitazone on Insulin-and IGF-1-Stimulated Cells
- Phosphatidylinositol 3–kinase Activity Is Required for Hepatocyte Growth Factor-induced Mitogenic Signals in Epithelial Cells
- Role of Phosphatidylinositol 3–kinase during the first cell cycles of the sea urchin embryo. Effect on map kinase and MPF activities.
- P-62: Role of Phosphatidylinositol–3–kinase and S6 kinase in insulin-stimulated glycogen synthesis
- The effects of fluid shear stress on the activity of protein kinase C, Phosphatidylinositol 3–kinase and Rho in aortic endothelial cells
- Role of p38 and Phosphatidylinositol 3 kinase (PI3K) in the signal transduction of apoptosis of activated human?? T cells induced by restimulating with Mycobacterium …
- Phosphatidylinositol 3 kinase (PI 3 K) regulates glomerular mesangial cell chemotaxis and proliferation: Involvement of mitogen activated protein kinase (MAPK) …
- Phosphatidylinositol 3–kinase regulates actin stress fiber formation and the avidity of the integrin-receptor α, β 3 in human melanoma cells.
- Regulation of early endosomal transport and fusion by ADP-ribosylation factors and Phosphatidylinositol 3–kinase
- P-78: Role of p85 isoforms of Phosphatidylinositol–3–kinase in insulin receptor signaling
- Translocation of Phosphatidylinositol–3 kinase (PI3–kinase) and small GTPase Rho A to the cytoskeleton upon osteoclast attachment to bone.
- Phosphatidylinositol 3–kinase regulates actin stress fiber formation and the avidity of the integrin-receptor αvβ3 in human melanoma cells.
- Tyrosine residue 719 of the c-kit receptor is essential for binding of the P85 subunit of Phosphatidylinositol (PI) 3–kinase and for c-kit-associated PI 3–kinase activity in …
- … derived growth factor triggers translocation of the insulin-regulatable glucose transporter (type 4) predominantly through Phosphatidylinositol 3–kinase binding sites on …
- P-77: Insulinomimetic agent, vanadyl sulfate (VS)-stimulated Phosphatidylinositol 3–kinase (PI 3-K) and RAS/MAP kinase activation is independent of insulin receptor …
- Effect of phosphotyrosyl‐IRS‐1 level and insulin receptor tyrosine kinase activity on insulin‐stimulated Phosphatidylinositol 3, MAP, and S6 kinase activities
- Phosphorylation of Tyrosine 503 in the Erythropoietin Receptor (EpR) Is Essential for Binding the P85 Subunit of Phosphatidylinositol (PI) 3–kinase and for …
- Protein kinase B (c-Akt): a multifunctional mediator of Phosphatidylinositol 3–kinase activation
- A requirement for Phosphatidylinositol 3–kinase in pseudopod extension
- Downstream signalling events regulated by Phosphatidylinositol 3–kinase activity
- p110δ, a novel Phosphatidylinositol 3–kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes
- A specific product of Phosphatidylinositol 3–kinase directly activates the protein kinase Akt through its pleckstrin homology domain
- The role of Phosphatidylinositol 3–kinase in vascular endothelial growth factor signaling
- Cyclin D expression is controlled post-transcriptionally via a Phosphatidylinositol 3–kinase/Akt-dependent pathway
- Role of glycogen synthase kinase–3 in the Phosphatidylinositol 3–kinase/Akt cell survival pathway
- Antiapoptotic signalling by the insulin-like growth factor I receptor, Phosphatidylinositol 3–kinase, and Akt
- Calmodulin activates Phosphatidylinositol 3–kinase
- Phosphatidylinositol 3–kinase-dependent membrane association of the Bruton’s tyrosine kinase pleckstrin homology domain visualized in single living cells
- Regulation of the p85/p110 Phosphatidylinositol 3′-kinase: stabilization and inhibition of the p110α catalytic subunit by the p85 regulatory subunit
- Neuroprotection by brain-derived neurotrophic factor is mediated by extracellular signal-regulated kinase and Phosphatidylinositol 3–kinase
- Phosphatidylinositol 3–kinase couples the interleukin-2 receptor to the cell cycle regulator E2F
- Ezrin, a plasma membrane–microfilament linker, signals cell survival through the Phosphatidylinositol 3–kinase/Akt pathway
- Suppression of transforming growth factor-β-induced apoptosis through a Phosphatidylinositol 3–kinase/Akt-dependent pathway
- Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the Phosphatidylinositol 3–kinase/Akt pathway
- PTEN interactions with focal adhesion kinase and suppression of the extracellular matrix-dependent Phosphatidylinositol 3–kinase/Akt cell survival pathway
- Vascular endothelial growth factor regulates endothelial cell survival through the Phosphatidylinositol 3′-kinase/Akt signal transduction pathway …
- Depolarization and neurotrophins converge on the Phosphatidylinositol 3–kinase–Akt pathway to synergistically regulate neuronal survival
- Relationship between flavonoid structure and inhibition of Phosphatidylinositol 3–kinase: a comparison with tyrosine kinase and protein kinase C inhibition
- Myogenic signaling of Phosphatidylinositol 3–kinase requires the serine-threonine kinase Akt/protein kinase B
- Requirement of Phosphatidylinositol 3–kinase in focal adhesion kinase-promoted cell migration
- Identification of an early endosomal protein regulated by Phosphatidylinositol 3–kinase
- Activation of the Phosphatidylinositol 3–kinase serine kinase by IFN-alpha.
- The Phosphatidylinositol 3‐kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes
- Constitutive activation of Phosphatidylinositol 3–kinase by a naturally occurring mutant epidermal growth factor receptor
- Akt, a target of Phosphatidylinositol 3–kinase, inhibits apoptosis in a differentiating neuronal cell line
- Regulation of the p85/p110α Phosphatidylinositol 3′-kinase: distinct roles for the N-terminal and C-terminal SH2 domains
- Activated Phosphatidylinositol 3–kinase and Akt kinase promote survival of superior cervical neurons
- Increased levels of Phosphatidylinositol 3‐kinase activity in colorectal tumors
- Protein kinase C-ζ as a downstream effector of Phosphatidylinositol 3–kinase during insulin stimulation in rat adipocytes: potential role in glucose transport
- Phosphatidylinositol 3–kinase and Akt protein kinase are necessary and sufficient for the survival of nerve growth factor-dependent sympathetic neurons
- Phosphatidylinositol 3‐kinase‐mediated regulation of neuronal apoptosis and necrosis by insulin and IGF‐I
- Identification and analysis of PH domain-containing targets of Phosphatidylinositol 3–kinase using a novel in vivo assay in yeast
- Phosphatidylinositol 3–kinase is required for integrin-stimulated AKT and Raf-1/mitogen-activated protein kinase pathway activation
- Comparison of the roles of mitogen-activated protein kinase kinase and Phosphatidylinositol 3–kinase signal transduction in neutrophil effector function
- Activation of Phosphatidylinositol 3–kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-κB p65/RelA subunit
- Induction of Vascular Endothelial Growth Factor by Hypoxia Is Modulated by a Phosphatidylinositol 3–kinase/Akt Signaling Pathway in Ha-ras-Transformed Cells …
- Activation of Phosphatidylinositol 3–kinase is sufficient for cell cycle entry and promotes cellular changes characteristic of oncogenic transformation
- STAT3 as an adapter to couple Phosphatidylinositol 3–kinase to the IFNAR1 chain of the type I interferon receptor
- Insulin-dependent translocation of ARNO to the plasma membrane of adipocytes requires Phosphatidylinositol 3–kinase
- Heregulin induces phosphorylation of BRCA1 through Phosphatidylinositol 3–kinase/AKT in breast cancer cells
- Phosphatidylinositol 3–kinase is required for platelet-derived growth factor’s actions on hepatic stellate cells
- FAK is the upstream signal protein of the Phosphatidylinositol 3–kinase-Akt survival pathway in hydrogen peroxide-induced apoptosis of a human …
- An essential role of Phosphatidylinositol 3–kinase in myogenic differentiation
- Phosphatidylinositol 3–kinase-γ activates Bruton’s tyrosine kinase in concert with Src family kinases
- Phosphatidylinositol 3–kinase in interleukin 1 signaling: physical interaction with the interleukin 1 receptor and requirement in NFκB and AP-1 activation
- Insulin-like growth factor 1 inhibits apoptosis using the Phosphatidylinositol 3′-kinase and mitogen-activated protein kinase pathways
- The Phosphatidylinositol 3′-kinase pathway is a dominant growth factor-activated cell survival pathway in LNCaP human prostate carcinoma cells
- … the protein kinase Akt/PKB by the formation of E-cadherin-mediated cell-cell junctions: evidence for the association of Phosphatidylinositol 3–kinase with the E …
- Angiotensin II activates Phosphatidylinositol 3–kinase in vascular smooth muscle cells
- p85α gene generates three isoforms of regulatory subunit for Phosphatidylinositol 3–kinase (PI 3–kinase), p50α, p55α, and p85α, with different PI 3–kinase …
- Effects of free fatty acids on glucose transport and IRS-1–associated Phosphatidylinositol 3–kinase activity
- Nitric oxide stimulates skeletal muscle glucose transport through a calcium/contraction–and Phosphatidylinositol–3–kinase–independent pathway
- Adenoviral gene transfer of activated Phosphatidylinositol 3′-kinase and Akt inhibits apoptosis of hypoxic cardiomyocytes in vitro
- Interleukin 8-stimulated Phosphatidylinositol–3–kinase activity regulates the migration of human neutrophils independent of extracellular signal-regulated kinase and …
- Differentiated phenotype of smooth muscle cells depends on signaling pathways through insulin-like growth factors and Phosphatidylinositol 3–kinase
- The protein-tyrosine phosphatase TCPTP regulates epidermal growth factor receptor-mediated and Phosphatidylinositol 3–kinase-dependent signaling
- Inhibition of adipose differentiation by Phosphatidylinositol 3‐kinase inhibitors
- Induction of vascular endothelial growth factor expression in endothelial cells by platelet-derived growth factor through the activation of Phosphatidylinositol 3–kinase
- Midkine inhibits caspase-dependent apoptosis via the activation of mitogen-activated protein kinase and Phosphatidylinositol 3–kinase in cultured neurons.
- Phosphatidylinositol 3–kinase links the interleukin-2 receptor to protein kinase B and p70 S6 kinase
- Distinct roles of the Phosphatidylinositol 3–kinase and STAT5 pathways in IL-7-mediated development of human thymocyte precursors
- MAP kinases, Phosphatidylinositol 3‐kinase, and p70 S6 kinase mediate the mitogenic response of human endothelial cells to vascular endothelial growth factor
- Requirement for both Shc and Phosphatidylinositol 3′ kinase signaling pathways in polyomavirus middle T-mediated mammary tumorigenesis
- Negative regulation by Phosphatidylinositol 3–kinase of inducible nitric oxide synthase expression in macrophages
- c-Src is required for stimulation of gelsolin-associated Phosphatidylinositol 3–kinase
- Altered expression levels and impaired steps in the pathway to Phosphatidylinositol 3–kinase activation via insulin receptor substrates 1 and 2 in Zucker fatty rats
- Contribution of Phosphatidylinositol 3‐kinase to radiation resistance in human melanoma cells
- Lysophosphatidic acid is a major serum noncytokine survival factor for murine macrophages which acts via the Phosphatidylinositol 3–kinase signaling pathway.
- Increase in nuclear Phosphatidylinositol 3‐kinase activity and Phosphatidylinositol (3, 4, 5) trisphosphate synthesis precede PKC‐ζ translocation to the nucleus of NGF …
- Src-induced activation of inducible T cell kinase (ITK) requires Phosphatidylinositol 3–kinase activity and the Pleckstrin homology domain of inducible T cell kinase
- Epidermal growth factor promotes MDA-MB-231 breast cancer cell migration through a Phosphatidylinositol 3′-kinase and phospholipase C-dependent mechanism
- … oxide synthase phosphorylation sites by mass spectrometry and regulation of phosphorylation and nitric oxide production by the Phosphatidylinositol 3–kinase …
- Matrix-dependent Tiam1/Rac signaling in epithelial cells promotes either cell–cell adhesion or cell migration and is regulated by Phosphatidylinositol 3–kinase
- Platelet-derived growth factor β receptor regulates interstitial fluid homeostasis through Phosphatidylinositol–3′ kinase signaling
- Wortmannin, a specific inhibitor of Phosphatidylinositol–3–kinase, enhances LPS-induced NO production from murine peritoneal macrophages
- Antiapoptotic signaling in LNCaP prostate cancer cells: a survival signaling pathway independent of Phosphatidylinositol 3′-kinase and Akt/protein kinase B
- Extracellular‐regulated kinases and Phosphatidylinositol 3‐kinase are involved in brain‐derived neurotrophic factor‐mediated survival and neuritogenesis of the …
- Phosphatidylinositol 3–kinase mediates mitogen-induced human airway smooth muscle cell proliferation
- Phosphatidylinositol 3‐kinase is recruited to a specific site in the activated IL‐1 receptor I
- Phosphatidylinositol 3–kinase is a negative regulator of cellular differentiation
- Etk/Bmx, a tyrosine kinase with a pleckstrin-homology domain, is an effector of Phosphatidylinositol 3′-kinase and is involved in interleukin 6-induced …
- Tyrosine 1101 of Tie2 is the major site of association of p85 and is required for activation of Phosphatidylinositol 3–kinase and Akt
- The Antiapoptotic Gene mcl-1 Is Up-Regulated by the Phosphatidylinositol 3–kinase/Akt Signaling Pathway through a Transcription Factor Complex Containing …
- Cyclin D1 Expression Mediated by Phosphatidylinositol 3–kinase through mTOR-p70S6K-Independent Signaling in Growth Factor-Stimulated NIH 3T3 Fibroblasts
- Regulation of vascular smooth muscle cell apoptosis: modulation of Bad by a Phosphatidylinositol 3–kinase–dependent pathway
- Activated MEK stimulates expression of AP-1 components independently of Phosphatidylinositol 3–kinase (PI3–kinase) but requires a PI3–kinase signal to stimulate …
- Phosphatidylinositol 3–kinase mediates epidermal growth factor-induced activation of the c-Jun N-terminal kinase signaling pathway
- Distinct Phosphatidylinositol 3–kinase lipid products accumulate upon oxidative and osmotic stress and lead to different cellular responses
- Activation of Phosphatidylinositol 3–kinase through glycoprotein 130 induces protein kinase B and p70 S6 kinase phosphorylation in cardiac myocytes
- Inhibition of Phosphatidylinositol 3–kinase activity blocks depolarization-and insulin-like growth factor I-mediated survival of cerebellar granule cells
- Heregulin regulates cytoskeletal reorganization and cell migration through the p21-activated kinase-1 via Phosphatidylinositol–3 kinase
- p70s6k Integrates Phosphatidylinositol 3–kinase and Rapamycin-Regulated Signals for E2F Regulation in T Lymphocytes
- Inhibition of Phosphatidylinositol 3–kinase activity by adenovirus-mediated gene transfer and its effect on insulin action
- … -permeable AMPA receptors induce phosphorylation of cAMP response element-binding protein through a Phosphatidylinositol 3–kinase-dependent stimulation of the …
- Insulin stimulation of the fatty acid synthase promoter is mediated by the Phosphatidylinositol 3–kinase pathway: involvement of protein kinase B/Akt
- Phosphatidylinositol 3–kinase γ mediates shear stress-dependent activation of JNK in endothelial cells
- Hyperglycemia inhibits insulin activation of Akt/protein kinase B but not Phosphatidylinositol 3–kinase in rat skeletal muscle.
- αPIX nucleotide exchange factor is activated by interaction with Phosphatidylinositol 3–kinase
- Insulin receptor substrate-1 phosphorylation and Phosphatidylinositol 3–kinase activity in skeletal muscle from NIDDM subjects after in vivo insulin stimulation
- Dedifferentiation of adenocarcinomas by activation of Phosphatidylinositol 3–kinase
- Role of Phosphatidylinositol 3–kinase activation in the hypertrophic growth of adult ventricular cardiomyocytes
- A redox-triggered ras-effector interaction: recruitment of Phosphatidylinositol 3′-kinase to Ras by redox stress
- Intermolecular interactions of the p85α regulatory subunit of Phosphatidylinositol 3–kinase
- Vac1p coordinates Rab and Phosphatidylinositol 3–kinase signaling in Vps45p-dependent vesicle docking/fusion at the endosome
- Requirement of Phosphatidylinositol–3 kinase for activation of JNK/SAPKs by PDGF
- 1α,25-Dihydroxyvitamin D3–Induced Myeloid Cell Differentiation Is Regulated by a Vitamin D Receptor–Phosphatidylinositol 3–kinase Signaling Complex
- Oxidative stress disrupts insulin-induced cellular redistribution of insulin receptor substrate-1 and Phosphatidylinositol 3–kinase in 3T3-L1 adipocytes: a …
- … rescue cerebellar granule neurons from oxidative stress‐mediated apoptotic death: selective involvement of Phosphatidylinositol 3‐kinase and the mitogen‐activated …
- Phosphatidylinositol 3–kinase activation is required for insulin-stimulated sodium transport in A6 cells
- Requirement of Phosphatidylinositol 3–kinase-dependent pathway and Src for Gas6-Axl mitogenic and survival activities in NIH 3T3 fibroblasts
- The p85 subunit of Phosphatidylinositol 3–kinase associates with the Fc receptor γ-chain and linker for activitor of T cells (LAT) in platelets stimulated by …
- Phosphatidylinositol 3–kinase-dependent activation of protein kinase C-ζ in bacterial lipopolysaccharide-treated human monocytes
- Expression of a constitutively active Phosphatidylinositol 3–kinase induces process formation in rat PC12 cells: use of Cre/loxP recombination system
- Inhibition of Phosphatidylinositol 3–kinase induces nitric-oxide synthase in lipopolysaccharide-or cytokine-stimulated C6 glial cells
- Receptors of the glial cell line-derived neurotrophic factor family of neurotrophic factors signal cell survival through the Phosphatidylinositol 3–kinase pathway in spinal …
- AKT2, a Member of the Protein kinase B Family, Is Activated by Growth Factors, v-Ha-ras, and v-src through Phosphatidylinositol 3–kinase in Human Ovarian …
- Activation of protein kinase C-ζ and Phosphatidylinositol 3′-kinase and promotion of macrophage differentiation by insulin-like growth factor-I
- Phosphatidylinositol 3–kinase contributes to Erk1/Erk2 MAP kinase activation associated with hepatocyte growth factor-induced cell scattering
- Downstream of Phosphatidylinositol–3 kinase, a multifunctional signaling molecule, and its regulation in cell responses
- Human dopamine D3 receptors mediate mitogen-activated protein kinase activation via a Phosphatidylinositol 3–kinase and an atypical protein kinase C-dependent …
- Phosphatidylinositol‐3 kinase is involved in ruffled border formation in osteoclasts
- Membrane-targeted Phosphatidylinositol 3–kinase mimics insulin actions and induces a state of cellular insulin resistance
- A function for Phosphatidylinositol 3–kinase β (p85α-p110β) in fibroblasts during mitogenesis: requirement for insulin-and lysophosphatidic acid-mediated signal …
- Phosphatidylinositol 3‐kinase and Akt protein kinase mediate IGF‐I‐and prosaptide‐induced survival in Schwann cells
- Activation of Phosphatidylinositol 3‐kinase, but not extracellular‐regulated kinases, is necessary to mediate brain‐derived neurotrophic factor‐induced motoneuron …
- Phosphatidylinositol 3–kinase contributes to cell volume regulation through effects on ATP release
- Phosphatidylinositol 3–kinase is required for the formation of constitutive transport vesicles from the TGN
- Enhanced Phosphatidylinositol 3–kinase activity and high phosphorylation state of its downstream signalling molecules mediated by ret with the MEN 2B mutation
- A collagen-related peptide regulates phospholipase Cγ2 via Phosphatidylinositol 3–kinase in human platelets
- Phosphatidylinositol 3‐kinase: increased activity and protein level in amyotrophic lateral sclerosis
- Enhanced insulin-stimulated activation of Phosphatidylinositol 3–kinase in the liver of high-fat-fed rats.
- SHP-1 regulates Lck-induced Phosphatidylinositol 3–kinase phosphorylation and activity
- Insulin-like growth factors require Phosphatidylinositol 3–kinase to signal myogenesis: dominant negative p85 expression blocks differentiation of L6E9 muscle cells
- DHEA improves glucose uptake via activations of protein kinase C and Phosphatidylinositol 3–kinase
- Insulin-like growth factor-II, Phosphatidylinositol 3–kinase, nuclear factor-κB and inducible nitric-oxide synthase define a common myogenic signaling pathway
- Phosphorylation of CD19 Y484 and Y515, and linked activation of Phosphatidylinositol 3–kinase, are required for B cell antigen receptor-mediated activation of …
- The B cell antigen receptor activates the Akt (protein kinase B)/glycogen synthase kinase–3 signaling pathway via Phosphatidylinositol 3–kinase
- Endosomal recycling of the Na+/H+ exchanger NHE3 isoform is regulated by the Phosphatidylinositol 3–kinase pathway
- Differential effects of constitutively active Phosphatidylinositol 3–kinase on glucose transport, glycogen synthase activity, and DNA synthesis in 3T3-L1 adipocytes
- Interleukin-6 inhibits transforming growth factor-β-induced apoptosis through the Phosphatidylinositol 3–kinase/Akt and signal transducers and activators of …
- … in response to dexamethasone is associated with inhibition of insulin-like growth factor-I stimulated Phosphatidylinositol 3–kinase activity in cultured muscle …
- Requirement for Phosphatidylinositol–3′-kinase in cytokine-mediated germ cell survival during fetal oogenesis in the mouse
- Insulin receptor substrate (IRS) 1 is reduced and IRS-2 is the main docking protein for Phosphatidylinositol 3–kinase in adipocytes from subjects with non-insulin …
- Defective regulation of Phosphatidylinositol–3–kinase gene expression in skeletal muscle and adipose tissue of non-insulin-dependent diabetes mellitus patients
- … transporter mRNAs in response to insulin: role of mammalian target of rapamycin, protein kinase b, and Phosphatidylinositol 3–kinase in GLUT1 mRNA …
- Grb2-associated binder-1 mediates Phosphatidylinositol 3–kinase activation and the promotion of cell survival by nerve growth factor
- Phosphorylation–dependent interaction of the N‐methyl‐ d‐aspartate receptor ε2 subunit with Phosphatidylinositol 3‐kinase
- Differential regulation of insulin receptor substrates-1 and-2 (IRS-1 and IRS-2) and Phosphatidylinositol 3–kinase isoforms in liver and muscle of the obese diabetic (ob …
- Phosphatidylinositol 3–kinase-mediated Endocytosis of Renal Na+,K+-ATPase α Subunit in Response to Dopamine
- Involvement of Phosphatidylinositol 3–kinase in stromal cell-derived factor-1α-induced lymphocyte polarization and chemotaxis
- Protein kinase B (c-Akt), Phosphatidylinositol 3–kinase, and STAT5 are activated by erythropoietin (EPO) in HCD57 erythroid cells but are constitutively active in an …
- Hepatocyte growth factor promotes migration of human hepatocellular carcinoma via Phosphatidylinositol 3–kinase
- Inhibition of Phosphatidylinositol–3–kinase blocks development of functional embryonic cardiomyocytes
- … prolactin stimulate tyrosine phosphorylation of insulin receptor substrate-1,-2, and-3, their association with p85 Phosphatidylinositol 3–kinase (PI3–kinase), and …
- Roles of Phosphatidylinositol 3–kinase and mitogen-activated protein kinase pathways in stimulation of vascular smooth muscle cell migration and deoxyriboncleic …
- TGF-β1 modulates EGF-stimulated Phosphatidylinositol 3–kinase activity in human airway smooth muscle cells
- Phosphatidylinositol 3–kinase is involved in the protection of primary cultured human erythroid precursor cells from apoptosis
- Phosphatidylinositol 3–kinase is a target for protein tyrosine nitration
- Phosphatidylinositol–3 kinase is necessary for 12-O-tetradecanoylphorbol-13-acetate-induced cell transformation and activated protein 1 activation
- p21 ras and Phosphatidylinositol–3 kinase are required for survival of wild-type and NF1 mutant sensory neurons
- Modulation of insulin receptor substrate-1 tyrosine phosphorylation by an Akt/Phosphatidylinositol 3–kinase pathway
- … -activated protein kinase activation through Fcε receptor I and stem cell factor receptor is differentially regulated by Phosphatidylinositol 3–kinase and calcineurin in …
- Microinjection of activated Phosphatidylinositol–3 kinase induces process outgrowth in rat PC12 cells through the Rac-JNK signal transduction pathway
- Prolactin induced tyrosine phosphorylation of p59fyn may mediate Phosphatidylinositol 3–kinase activation in Nb2 cells.
- Glucagon-like peptide-1 promotes DNA synthesis, activates Phosphatidylinositol 3–kinase and increases transcription factor pancreatic and duodenal homeobox gene …
- Phosphatidylinositol 3–kinase is involved in the induction of macrophage growth by oxidized low density lipoprotein
- Phosphatidylinositol 3–kinase Requirement in Activation of the ras/C-raf-1/MEK/ERK and p70s6k Signaling Cascade by the Insulinomimetic Agent Vanadyl Sulfate
- Ataxia‐telangiectasia without immunodeficiency: Novel point mutations within and adjacent to the Phosphatidylinositol 3‐kinase‐like domain
- Steel factor induces tyrosine phosphorylation of CRKL and binding of CRKL to a complex containing c-Kit, Phosphatidylinositol 3–kinase, and p120CBL
- Modification of Phosphatidylinositol 3–kinase SH2 domain binding properties by Abl-or Lck-mediated tyrosine phosphorylation at Tyr-688
- Identification of a common amino acid polymorphism in the p85α regulatory subunit of Phosphatidylinositol 3–kinase: effects on glucose disappearance constant …
- Region‐specific mRNA expression of Phosphatidylinositol 3‐kinase regulatory isoforms in the central nervous system of C57BL/6J mice
- Heat shock activates c-Src tyrosine kinases and Phosphatidylinositol 3–kinase in NIH3T3 fibroblasts
- Evidence of a role for Phosphatidylinositol 3–kinase activation in the blocking of apoptosis by polyomavirus middle T antigen
- Comparative Effects of GTPγS and Insulin on the Activation of Rho, Phosphatidylinositol 3–kinase, and Protein kinase N in Rat Adipocytes: RELATIONSHIP …
- Nerve growth factor protects PC12 cells against peroxynitrite‐induced apoptosis via a mechanism dependent on Phosphatidylinositol 3‐kinase
- Activation of Phosphatidylinositol 3–kinase, protein kinase B, and p70 S6 kinases in lipopolysaccharide-stimulated Raw 264.7 cells: differential effects of rapamycin …
- Phosphatidylinositol 3–kinase association with the osteoclast cytoskeleton, and its involvement in osteoclast attachment and spreading
- … of the ADP-ribosylation factor-exchange factor GRP1 to the plasma membrane of PC12 cells requires activation of Phosphatidylinositol 3–kinase and the GRP1 …
- Thymocyte activation induces the association of Phosphatidylinositol 3‐kinase and pp120 with CD5
- Heregulin β1-activated Phosphatidylinositol 3–kinase enhances aggregation of MCF-7 breast cancer cells independent of extracellular signal-regulated kinase
- Phosphatidylinositol 3–kinase Is Required for Growth Factor–Induced Amino Acid Uptake by Vascular Smooth Muscle Cells
- The proto-oncogene product p120cbl links c-Src and Phosphatidylinositol 3′-kinase to the integrin signaling pathway
- CD28 receptor endocytosis is targeted by mutations that disrupt Phosphatidylinositol 3–kinase binding and costimulation
- Protein kinase B/Akt is activated by polyomavirus middle-T antigen via a Phosphatidylinositol 3–kinase-dependent mechanism
- Assessment of the roles of mitogen-activated protein kinase, Phosphatidylinositol 3–kinase, protein kinase B, and protein kinase C in insulin inhibition of cAMP …
- Thrombopoietin induces activation of the Phosphatidylinositol‐3′ kinase pathway and formation of a complex containing p85PI3K and the protooncoprotein p120CBL
- Signaling through CD5 activates a pathway involving Phosphatidylinositol 3–kinase, Vav, and Rac1 in human mature T lymphocytes
- Tyrosine phosphorylation of p120cbl in BCR/abl transformed hematopoietic cells mediates enhanced association with Phosphatidylinositol 3–kinase
- Erythropoietin induces the tyrosine phosphorylation of GAB1 and its association with SHC, SHP2, SHIP, and Phosphatidylinositol 3–kinase
- Epidermal growth factor modulates tyrosine phosphorylation of p130Cas: involvement of Phosphatidylinositol 3′-kinase and actin cytoskeleton
- Phosphatidylinositol 3′-kinase and SH2-containing inositol phosphatase (SHIP) are recruited by distinct positive and negative growth-regulatory domains in the …
- Selective up-regulation of Phosphatidylinositol 3′-kinase activity in Th2 cells inhibits caspase-8 cleavage at the death-inducing complex: a mechanism for Th2 …
- Inhibition of Phosphatidylinositol 3–kinase activity elevates c-Jun N-terminal kinase activity in apoptosis of cultured cerebellar granule neurons
- Vanadyl sulfate-stimulated glycogen synthesis is associated with activation of Phosphatidylinositol 3–kinase and is independent of insulin receptor tyrosine …
- Phosphatidylinositol 3–kinase-dependent and-independent cytolytic effector functions
- Activation of Phosphatidylinositol 3–kinase by interleukin-13: an inhibitory signal for inducible nitric-oxide synthase expression in epithelial cell line HT-29
- G1 phase arrest by the Phosphatidylinositol 3–kinase inhibitor LY 294002 is correlated to up-regulation of p27Kip1 and inhibition of G1 CDKs in choroidal …
- Phosphatidylinositol 3′-kinase-independent p70 S6 kinase activation by fibroblast growth factor receptor-1 is important for proliferation but not differentiation …
- … Tyrosine Phosphorylation of p130Cas, Focal Adhesion kinase, and Paxillin: ROLE OF Phosphatidylinositol 3′-kinase AND FORMATION OF A …
- Gastrin stimulates the formation of a p60Src/p125FAK complex upstream of the Phosphatidylinositol 3–kinase signaling pathway
- A Phosphatidylinositol 3–kinase inhibitor induces a senescent-like growth arrest in human diploid fibroblasts
- A Phosphatidylinositol 3–kinase and Phosphatidylinositol transfer protein act synergistically in formation of constitutive transport vesicles from the trans-Golgi …
- Insulin-like growth factor (IGF)-I regulates IGF-binding protein-5 gene expression through the Phosphatidylinositol 3–kinase, protein kinase B/Akt, and p70 S6 …
- α-Adrenergic stimulation mediates glucose uptake through Phosphatidylinositol 3–kinase in rat heart
- A Phosphatidylinositol 3‐kinase inhibitor wortmannin induces radioresistant DNA synthesis and sensitizes cells to bleomycin and ionizing radiation
- Intracellular movement of green fluorescent protein–tagged Phosphatidylinositol 3–kinase in response to growth factor receptor signaling
- Activation and translocation of Rho (and ADP ribosylation factor) by insulin in rat adipocytes: apparent involvement of Phosphatidylinositol 3–kinase
- Intermediate affinity interleukin-2 receptor mediates survival via a Phosphatidylinositol 3–kinase-dependent pathway
- The Phosphatidylinositol 3–kinase inhibitor wortmannin markedly reduces chemotactic peptide-induced locomotion and increases in cytoskeletal actin in human …
- … pervanadate, stimulate glucose transport and GLUT translocation in muscle cells by a mechanism independent of Phosphatidylinositol 3–kinase and protein kinase C.
- The Phosphatidylinositol 3‐kinase inhibitor wortmannin alters the metabolism of the Alzheimer’s amyloid precursor protein
- … tyrosine kinase inhibits inducible nitric oxide synthase (iNOS) expression by murine peritoneal exudate macrophages: Phosphatidylinositol–3 kinase is required for …
- Involvement of Phosphatidylinositol 3–kinase in NFAT activation in T cells
- Endothelin-1 modulates insulin signaling through Phosphatidylinositol 3–kinase pathway in vascular smooth muscle cells.
- Phosphatidylinositol 3–kinase in HL-60 nuclei is bound to the nuclear matrix and increases during granulocytic differentiation
- Multiple isoforms of the regulatory subunit for Phosphatidylinositol 3–kinase (PI3–kinase) are expressed in neurons in the rat brain
- The CC chemokine monocyte chemotactic peptide-1 activates both the class I p85/p110 Phosphatidylinositol 3–kinase and the class II PI3K-C2α
- The p85 and p110 subunits of Phosphatidylinositol 3–kinase-α are substrates, in vitro, for a constitutively associated protein tyrosine kinase in platelets
- Phosphatidylinositol 3–kinase translocation to the nucleus is induced by interleukin 1 and prevented by mutation of interleukin 1 receptor in human osteosarcoma …
- The epidermal growth factor receptor associates with and recruits Phosphatidylinositol 3–kinase to the platelet-derived growth factor β receptor
- The Phosphatidylinositol 3′ kinase pathway is required for the survival signal of leukocyte tyrosine kinase
- Phosphatidylinositol 3–kinase is a requirement for insulin-like growth factor I-induced differentiation, but not for mitogenesis, in fetal brown adipocytes
- Stimulation of IRS-1-associated Phosphatidylinositol 3–kinase and Akt/protein kinase B but not glucose transport by β1-integrin signaling in rat adipocytes
- … colony-stimulating factor-activated signaling pathways in human neutrophils: involvement of Jak2 in the stimulation of Phosphatidylinositol 3–kinase
- CD38 ligation in human B cell progenitors triggers tyrosine phosphorylation of CD19 and association of CD19 with lyn and Phosphatidylinositol 3–kinase.
- MAP kinase activation by mu opioid receptor involves Phosphatidylinositol 3–kinase but not the cAMP/PKA pathway
- Platelet-derived growth factor-dependent cellular transformation requires either phospholipase Cγ or Phosphatidylinositol 3 kinase
- Sublytic C5b-9 induces proliferation of human aortic smooth muscle cells: role of mitogen activated protein kinase and Phosphatidylinositol 3–kinase
- … novel pathway for tumor necrosis factor-α and ceramide signaling involving sequential activation of tyrosine kinase, p21ras, and Phosphatidylinositol 3–kinase
- Synergistic roles of neuregulin-1 and insulin-like growth factor-I in activation of the Phosphatidylinositol 3–kinase pathway and cardiac chamber …
- Calmodulin is involved in membrane depolarization-mediated survival of motoneurons by Phosphatidylinositol–3 kinase-and MAPK-independent pathways
- p70 S6 kinase is activated by sodium arsenite in adult rat cardiomyocytes: roles for Phosphatidylinositol 3–kinase and p38 MAP kinase
- Phosphatidylinositol 3–kinase and Ca2+ influx dependence for ligand-stimulated internalization of the c-Kit receptor
- Epidermal growth factor receptor-regulated human bladder cancer motility is in part a Phosphatidylinositol 3–kinase-mediated process
- Involvement of Phosphatidylinositol–3 kinase in prevention of low K+-induced apoptosis of cerebellar granule neurons
- PTEN modulates cell cycle progression and cell survival by regulating Phosphatidylinositol 3, 4, 5,-trisphosphate and Akt/protein kinase B signaling pathway
- … lipopolysaccharide stimulate extracellularly regulated kinase activation in macrophages by a mechanism involving Phosphatidylinositol 3–kinase and phospholipase D …
- CD28 can promote T cell survival through a Phosphatidylinositol 3‐kinase‐independent mechanism
- SIP/SHIP inhibits Xenopus oocyte maturation induced by insulin and Phosphatidylinositol 3–kinase
- Insulin regulation of glucose-6-phosphate dehydrogenase gene expression is rapamycin-sensitive and requires Phosphatidylinositol 3–kinase
- Lysophosphatidylcholine generates superoxide anions through activation of Phosphatidylinositol 3–kinase in human neutrophils
- Insulin receptor substrate (IRS)-2 is dephosphorylated more rapidly than IRS-1 via its association with Phosphatidylinositol 3–kinase in skeletal muscle cells
- The survival of sympathetic neurons promoted by potassium depolarization, but not by cyclic AMP, requires Phosphatidylinositol 3‐kinase and Akt
- Nuclear translocation of PKCζ during ischemia and its inhibition by wortmannin, an inhibitor of Phosphatidylinositol 3–kinase
- CD7-mediated regulation of integrin adhesiveness on human T cells involves tyrosine phosphorylation-dependent activation of Phosphatidylinositol 3–kinase.
- LCK-phosphorylated human killer cell-inhibitory receptors recruit and activate Phosphatidylinositol 3–kinase
- 14-3–3β protein associates with insulin receptor substrate 1 and decreases insulin-stimulated Phosphatidylinositol 3′-kinase activity in 3T3L1 adipocytes
- Evidence that Phosphatidylinositol 3–kinase and p70S6K protein are involved in differentiation of HL-60 cells induced by calcitriol.
- Inhibition of Phosphatidylinositol 3‐kinase activity blocks cellular differentiation mediated by glial cell line‐derived neurotrophic factor in dopaminergic neurons
- Roles of Phosphatidylinositol 3–kinase and Rac in the nuclear signaling by tumor necrosis factor-α in rat-2 fibroblasts
- Inositol hexaphosphate inhibits cell transformation and activator protein 1 activation by targeting Phosphatidylinositol–3′ kinase
- The role of Phosphatidylinositol 3–kinase, Src kinase, and protein kinase A signaling pathways in insulin and glucagon regulation of CYP2E1 expression
- Mitogen-activated protein kinase and Phosphatidylinositol 3–kinase pathways are not sufficient for insulin-like growth factor I-induced mitogenesis and tumorigenesis
- Fc receptor-mediated platelet activation is dependent on Phosphatidylinositol 3–kinase activation and involves p120cbl
- Variant in the regulatory subunit of Phosphatidylinositol 3–kinase (p85alpha): preliminary evidence indicates a potential role of this variant in the acute insulin …
- … 3–kinase/p70 ribosomal S6 protein kinase pathway is required for the regulation by insulin of the p85α regulatory subunit of Phosphatidylinositol 3–kinase …
- The involvement of Phosphatidylinositol 3–kinase in crystal induced human neutrophil activation.
- Wortmannin inhibits the growth of mammary tumors despite the existence of a novel wortmannin-insensitive Phosphatidylinositol–3–kinase
- … receptors gives rise to the selective modulation of intracellular signaling in B cells: regulation of the association of Phosphatidylinositol 3–kinase and inositol 5 …
- Phosphatidylinositol 3′-kinase and tyrosine-phosphatase activation positively modulate Convulxin-induced platelet activation. Comparison with collagen
- Phosphorylation of cbl after Stimulation of Nb2 Cells with Prolactin and Its Association with Phosphatidylinositol 3–kinase
- Phosphatidylinositol 3–kinase translocates onto liver endoplasmic reticulum and may account for the inhibition of glucose-6-phosphatase during refeeding
- Regulation of endocytic-transcytotic pathways and bile secretion by Phosphatidylinositol 3–kinase in rats
- Cripto-1 induces Phosphatidylinositol 3′-kinase-dependent phosphorylation of AKT and glycogen synthase kinase 3β in human cervical carcinoma cells
- Epidermal growth factor stimulation of Phosphatidylinositol 3–kinase during wound closure in rabbit corneal epithelial cells.
- … induces the tyrosine phosphorylation of insulin receptor substrate-2: an alternate pathway for erythropoietin-induced Phosphatidylinositol 3–kinase activation
- Localization of a class II Phosphatidylinositol 3–kinase, PI3KC2α, to clathrin-coated vesicles
- Role of the vav proto-oncogene product (Vav) in erythropoietin-mediated cell proliferation and Phosphatidylinositol 3–kinase activity
- Possible involvement of Phosphatidylinositol 3‐kinase in regulated exocytosis: studies in chromaffin cells with inhibitor LY294002
- Src-family Tyrosine kinases in Activation of ERK-1 and p85/p110-Phosphatidylinositol 3–kinase by G/CCKBReceptors
- Signaling through the EBV/C3d receptor (CR2, CD21) in human B lymphocytes: activation of Phosphatidylinositol 3–kinase via a CD19-independent pathway
- Cloning of human p55γ, a regulatory subunit of Phosphatidylinositol 3–kinase, by a yeast two-hybrid library screen with the insulin-like growth factor-I receptor
- Angiotensin II induces activation of Phosphatidylinositol 3–kinase in cardiomyocytes
- Involvement of Phosphatidylinositol 3′‐kinase in stem‐cell‐factor‐induced phospholipase D activation and arachidonic acid release
- CD45-induced tumor necrosis factor α production in monocytes is Phosphatidylinositol 3–kinase-dependent and nuclear factor-κB-independent
- Wortmannin, a Phosphatidylinositol 3–kinase inhibitor, blocks antigen-mediated, but not CD3 monoclonal antibody-induced, activation of murine CD4+ T cells.
- Phosphatidylinositol 3–kinase is required for CD28 but not CD3 regulation of the TEC family tyrosine kinase EMT/ITK/TSK: functional and physical interaction of EMT …
- Endothelin-1-induced GLUT4 translocation is mediated via Gαq/11 protein and Phosphatidylinositol 3–kinase in 3T3-L1 adipocytes
- N-Methyl-D-aspartate inhibits apoptosis through activation of Phosphatidylinositol 3–kinase in cerebellar granule neurons: a role for insulin receptor substrate …
- Phosphatidylinositol 3‐kinase binds to profilin through the p85α subunit and regulates cytoskeletal assembly
- HMG-CoA reductase inhibitor-induced L6 myoblast cell death: involvement of the Phosphatidylinositol 3–kinase pathway
- Requirement for Ras and Phosphatidylinositol 3–kinase signaling uncouples the glucocorticoid-induced junctional organization and transepithelial electrical …
- Cell Interactions with Collagen Matrices In Vivo and In Vitro Depend on Phosphatidylinositol 3–kinase and Free Cytoplasmic Calcium
- Affinity modulation of very late antigen-5 through Phosphatidylinositol 3–kinase in mast cells
- Tyrosine phosphorylation of the CD3-ε subunit of the T cell antigen receptor mediates enhanced association with Phosphatidylinositol 3–kinase in Jurkat T …
- Platelet-derived growth factor inhibits insulin stimulation of insulin receptor substrate-1-associated Phosphatidylinositol 3–kinase in 3T3-L1 adipocytes without …
- … choline phosphate-induced mitogenesis in fibroblasts involves activation of pp70 S6 kinase and Phosphatidylinositol 3′-kinase through an extracellular site …
- Functional cooperation of the interleukin-2 receptor β chain and Jak1 in Phosphatidylinositol 3–kinase recruitment and phosphorylation
- … Factor–Activated Signaling Pathways in Human Neutrophils. I. Tyrosine Phosphorylation-Dependent Stimulation of Phosphatidylinositol 3–kinase and Inhibition by …
- Insulin receptor substrate-1 and Phosphatidylinositol 3–kinase regulate extracellular signal-regulated kinase-dependent and-independent signaling pathways during …
- Binding of receptor-recognized forms of α2-macroglobulin to the α2-macroglobulin signaling receptor activates Phosphatidylinositol 3–kinase
- … HT-29 cells is independent of nitric oxide formation: evidence for an interleukin-13-driven Phosphatidylinositol 3–kinase-dependent survival mechanism
- Involvement of protein tyrosine kinase p72syk and Phosphatidylinositol 3–kinase in CD2-mediated granular exocytosis in the natural killer cell line, NK3. 3.
- Expression of Phosphatidylinositol 3–kinase during EGF-Stimulated Wound Repair in Rabbit Corneal Epithelium
- Insulin-like growth factor-1 stimulates rat prolactin gene expression by a Ras, ETS and Phosphatidylinositol 3–kinase dependent mechanism
- SHP-1 associates with both platelet-derived growth factor receptor and the p85 subunit of Phosphatidylinositol 3–kinase
- CD72‐mediated B cell activation involves recruitment of CD19 and activation of Phosphatidylinositol 3‐kinase
- Action of insulin on the surface morphology of hepatocytes: role of Phosphatidylinositol 3–kinase in insulin-induced shape change of microvilli
- Biphasic activation of p21ras by endothelin-1 sequentially activates the ERK cascade and Phosphatidylinositol 3–kinase
- … factor of src-and hepatocyte growth factor-dependent invasiveness of intestinal and kidney epithelial cells: Phosphatidylinositol 3′-kinase is a critical …
- Identification and chromosome assignment of a human gene encoding a novel Phosphatidylinositol–3 kinase
- Phosphatidylinositol 3′-kinase, but not S6-kinase, is required for insulin-like growth factor-I and IL-4 to maintain expression of Bcl-2 and promote survival of myeloid …
- Epidermal growth factor and insulin-induced deoxyribonucleic acid synthesis in primary rat hepatocytes is Phosphatidylinositol 3–kinase dependent and dissociated …
- … (p125FAK) and paxillin in rat pancreatic acini by a phospholipase C-independent process that depends on Phosphatidylinositol 3–kinase, the small GTP …
- Effects of Phosphatidylinositol–3–kinase inhibitors on degranulation and gene induction in allergically triggered mouse mast cells
- Activation of Phosphatidylinositol 3‘-kinase by insulin-like growth factor-I rescues promyeloid cells from apoptosis and permits their differentiation into granulocytes.
- Epidermal growth factor stimulates phospholipase D independent of phospholipase C, protein kinase C or Phosphatidylinositol–3 kinase activation in immortalized …
- … diphosphotyrosine-containing peptide that mimics activated platelet-derived growth factor receptor β induces oligomerization of Phosphatidylinositol 3–kinase
- Monocytic differentiation of HL-60 cells is characterized by the nuclear translocation of Phosphatidylinositol 3–kinase and of definite Phosphatidylinositol-specific …
- Thapsigargin-induced secretion is dependent on activation of a cholera toxin-sensitive and Phosphatidylinositol–3–kinase-regulated phospholipase D in a mast cell …
- Changes in the mitogen-activated protein kinase and Phosphatidylinositol 3–kinase/Akt signaling associated with the induction of apoptosis.
- IL-2 signaling controls actin organization through Rho-like protein family, Phosphatidylinositol 3–kinase, and protein kinase C-zeta.
- A role for Phosphatidylinositol 3–kinase in platelet aggregation in response to low, but not high, concentrations of PAF or thrombin
- Differential association of Phosphatidylinositol 3–kinase with insulin receptor substrate (IRS)-1 and IRS-2 in human thymocytes in response to IL-7.
- Effect of wortmannin, an inhibitor of Phosphatidylinositol 3–kinase, on the first mitotic divisions of the fertilized sea urchin egg
- Platelet‐Derived Growth Factor Stimulates Sodium‐Dependent Pi Transport in Osteoblastic Cells via Phospholipase Cγ and Phosphatidylinositol 3′‐kinase
- Inhibition of human cardiac fibroblast mitogenesis by blockade of mitogen‐activated protein kinase and Phosphatidylinositol 3‐kinase
- Phosphatidylinositol 3–kinase and dynamics of insulin resistance in denervated slow and fast muscles in vivo
- Phosphatidylinositol 4-kinase, but not Phosphatidylinositol 3–kinase, is present in GLUT4-containing vesicles isolated from rat skeletal muscle
- Raf-1 kinase Activation by Angiotensin II in Adrenal Glomerulosa Cells: Roles of Gi, Phosphatidylinositol 3–kinase, and Ca2+ Influx
- The inositol polyphosphate 4-phosphatase forms a complex with Phosphatidylinositol 3–kinase in human platelet cytosol
- … chemokinesis in normal human neutrophils is dependent on D‐glucose concentration and sensitive to inhibitors of tyrosine kinase and Phosphatidylinositol 3‐kinase
- Brain‐derived neurotrophic factor stimulates interactions of Shp2 with Phosphatidylinositol 3‐kinase and Grb2 in cultured cerebral cortical neurons
- Phosphatidylinositol 3–kinase and focal adhesion kinase are early signals in the growth factor–like responses to thrombospondin-1 seen in human vascular smooth …
- Insulin stimulation of K+ uptake in 3T3-L1 fibroblasts involves Phosphatidylinositol 3–kinase and protein kinase C-zeta
- Phosphatidylinositol 3′-kinase and p70s6k are required for insulin but not bisperoxovanadium 1, 10-phenanthroline (bpV (phen)) inhibition of insulin-like …
- … secretagogues activate protein tyrosine phosphorylation and release of arachidonic acid in mast cells via a novel protein kinase C and Phosphatidylinositol 3‐kinase …
- Possible role for Phosphatidylinositol 3–kinase in regulating meiotic maturation of bovine oocytes in vitro
- Insulin receptor substrate (IRS)-1 and IRS-2 are tyrosine-phosphorylated and associated with Phosphatidylinositol 3–kinase in response to brain-derived …
- … C-γ1 renders platelet-derived growth factor β-receptor-expressing cells independent of the Phosphatidylinositol 3–kinase pathway for chemotaxis
- Activation of Phosphatidylinositol 3–kinase is necessary for differentiation of FDC-P1 cells following stimulation of type III receptor tyrosine kinases
- Potentiation of Insulin-Induced Phosphatidylinositol–3 kinase Activity by Phorbol Ester Is Mediated by Protein kinase Cϵ
- Phosphatidylinositol 3–kinase and protein kinase C are required for the inhibition of caspase activity by epidermal growth factor
- Signalling-competent truncated forms of ErbB2 in breast cancer cells: differential regulation by protein kinase C and Phosphatidylinositol 3–kinase
- Involvement of both the tyrosine kinase and the Phosphatidylinositol–3′ kinase signal transduction pathways in the regulation of lipoprotein lipase expression in J774 …
- Role of Phosphatidylinositol 3–kinase in degranulation induced by IgE-dependent and-independent mechanisms in rat basophilic RBL-2H3 (ml) cells
- PDGF-induced glycosaminoglycan synthesis is mediated via Phosphatidylinositol 3–kinase
- … new tyrosine-phosphorylated 97-kDa adaptor protein mediates interleukin-2-induced association of SHP-2 with p85-Phosphatidylinositol 3–kinase in human T …
- Phosphatidylinositol 3–kinase mediates heregulin-induced growth inhibition in human epithelial cells.
- Insulin activation of Phosphatidylinositol 3–kinase in human skeletal muscle in vivo
- … is tyrosine-phosphorylated by interleukin-4 and enhances mitogenic and survival signals of interleukin-4 receptor by linking with the Phosphatidylinositol 3′-kinase …
- Phosphatidylinositol 3–kinase inhibitors block aortic smooth muscle cell proliferation in mid-late G1 phase: effect on cyclin-dependent kinase 2 and the inhibitory …
- The Phosphatidylinositol 3–kinase inhibitor wortmannin sensitizes quiescent but not proliferating MG-63 human osteosarcoma cells to radiation
- Contrasting Signaling Pathways of α1A- and α1B-Adrenergic Receptor Subtype Activation of Phosphatidylinositol 3–kinase and Ras in Transfected NIH3T3 Cells
- Granulocyte-macrophage colony-stimulating factor and IL-5 activate mitogen-activated protein kinase through Jak2 kinase and Phosphatidylinositol 3–kinase inhuman …
- Inositide signalling in Chlamydomonas: characterization of a Phosphatidylinositol 3–kinase gene
- Suppression of insulin-stimulated Phosphatidylinositol 3–kinase activity by the β3-adrenoceptor agonist CL316243 in rat adipocytes
- Characterization of a novel tyrosine phosphorylated 100-kDa protein that binds to SHP-2 and Phosphatidylinositol 3′-kinase in myeloid cells
- Differential regulation of insulin receptor substrate-2 and mitogen-activated protein kinase tyrosine phosphorylation by Phosphatidylinositol 3–kinase inhibitors in SH …
- … and protein kinase C in dibutyryl cAMP-differentiated U937 cells is dependent solely on the tyrosine-kinase activated form of Phosphatidylinositol–3–kinase
- … to membrane expansion during growth of cultured embryonic mouse hippocampal neurons: sensitivity to inhibitors of Phosphatidylinositol 3–kinase and other protein …
- LY294002-mediated inhibition of Phosphatidylinositol 3–kinase activity triggers growth inhibition and apoptosis in CD40-triggered Ramos–Burkitt lymphoma B cells
- Oncogenic Ras-induced germinal vesicle breakdown is independent of Phosphatidylinositol 3–kinase in Xenopus oocytes
- The structural requirement of Phosphatidylinositols as substrate of Phosphatidylinositol 3–kinase
- Phosphatidylinositol 3–kinase regulates differentiation of H9c2 cardiomyoblasts mainly through the protein kinase B/Akt-independent pathway
- H-ras induces glucose uptake in brown adipocytes in an insulin-and Phosphatidylinositol 3–kinase-independent manner
- Interaction of Wild Type and Dominant-Negative p55PIK Regulatory Subunit of Phosphatidylinositol 3–kinase with Insulin-Like Growth Factor-1 Signaling Proteins
- Activation of S6 kinase in human neutrophils by calcium pyrophosphate dihydrate crystals: protein kinase C-dependent and Phosphatidylinositol–3–kinase …
- EGF activates ErbB-2 and stimulates Phosphatidylinositol 3–kinase in human airway smooth muscle cells
- CD16‐mediated activation of Phosphatidylinositol‐3 kinase (Pl‐3K) in human NK cells involves tyrosine phosphorylation of Cbl and its association with Grb2, Shc …
- Retinoic acid inhibits transformation by preventing Phosphatidylinositol 3–kinase dependent activation of the c-fos promoter
- Binding of HIV-1 to its receptor induces tyrosine phosphorylation of several CD4-associated proteins, including the Phosphatidylinositol 3–kinase
- … of bradykinin in the human colon carcinoma cell line SW-480 involves sequential activation of a Gq/11 protein, Phosphatidylinositol 3–kinase β, and protein …
- Insulin signalling in heart involves insulin receptor substrates-1 and-2, activation of Phosphatidylinositol 3–kinase and the JAK 2-growth related pathway
- Wortmannin blocks goldfish retinal Phosphatidylinositol 3–kinase and neurite outgrowth
- … transcription: involvement of the ligand-binding domain of the glucocorticoid receptor and independence from the Phosphatidylinositol 3–kinase and mitogen-activated …
- Binding of CD4 ligands induces tyrosine phosphorylation of Phosphatidylinositol–3 kinase p110 subunit.
- Involvement of Phosphatidylinositol 3–kinase and mitogen-activated protein kinase pathways in AII-mediated enhanced expression of Gi proteins in vascular smooth …
- … -1–induced cell-cycle progression: involvement of extracellular signal-regulated kinase, protein kinase C, and Phosphatidylinositol 3–kinase at distinct points
- Phosphatidylinositol 3–kinase in myogenesis
- Involvement of Phosphatidylinositol 3–kinase in the mediation of erythropoietin-induced activation of p70S6k
- Liver microsomal glucose-6-phosphatase is competitively inhibited by the lipid products of Phosphatidylinositol 3–kinase
- Interleukin-3 induces association of the protein-tyrosine phosphatase SHP2 and Phosphatidylinositol 3–kinase with a 100-kDa tyrosine-phosphorylated …
- Structural and biochemical evaluation of the interaction of the Phosphatidylinositol 3–kinase p85α Src homology 2 domains with phosphoinositides and …
- Phosphatidylinositol 3–kinase is required for the induction of ornithine decarboxylase in leukemia cells stimulated to growth
- Corneal epithelial wound healing increases the expression but not long lasting activation of the p85a subunit of Phosphatidylinositol–3 kinase
- Wortmannin, a Phosphatidylinositol 3–kinase inhibitor, blocks the assembly of peptide-MHC class II complexes.
- Design of peptidomimetics that inhibit the association of Phosphatidylinositol 3–kinase with platelet-derived growth factor-β receptor and possess cellular activity
- Monocyte adherence induced by lipopolysaccharide involves CD14, LFA-1, and cytohesin-1: regulation by Rho and Phosphatidylinositol 3–kinase
- Inhibition of MG‐63 cell proliferation and PDGF‐stimulated cellular processes by inhibitors of Phosphatidylinositol 3‐kinase
- Phosphorylation of Cbl following stimulation with interleukin-3 and its association with Grb2, Fyn, and Phosphatidylinositol 3–kinase
- JNK/SAPK activation by platelet-derived growth factor in A431 cells requires both the phospholipase C-γ and the Phosphatidylinositol 3–kinase signaling pathways of …
- Evidence for Phosphatidylinositol 3–kinase-dependent T cell antigen receptor (TCR) signal transduction
- Effects of Phosphatidylinositol 3–kinase inhibitors, wortmannin and LY294002, on germinal vesicle breakdown (GVBD) in porcine oocytes
- Phosphatidylinositol 3–kinase is not required for recycling of mannose 6-phosphate receptors from late endosomes to the trans-Golgi network.
- Islet transplantation restores normal levels of insulin receptor and substrate tyrosine phosphorylation and Phosphatidylinositol 3–kinase activity in skeletal muscle and …
- Cripto-1 inhibits beta-casein expression in mammary epithelial cells through a p21ras-and Phosphatidylinositol 3‘-kinase-dependent pathway.
- An Insulin-like Growth Factor-mediated, Phosphatidylinositol 3′ kinase-independent Survival Signaling Pathway in β Tumor Cells
- … a patient with severe insulin resistance: association of defective insulin-stimulated glucose transport with impaired Phosphatidylinositol 3–kinase activity in fibroblasts
- Hydrogen peroxide-induced activation of SAPK/JNK regulated by Phosphatidylinositol 3–kinase in Chinese hamster V79 cells
- Synergistic role of the Phosphatidylinositol 3–kinase and mitogen-activated protein kinase cascade in the regulation of insulin receptor trafficking
- Evidence that thrombin-stimulated DNA synthesis in pulmonary arterial fibroblasts involves Phosphatidylinositol 3–kinase-dependent p70 ribosomal S6 kinase …
- Phosphatidylinositol 3′-kinase associates with an insulin receptor substrate-1 serine kinase distinct from its intrinsic serine kinase
- Possibility of Distinct Insulin-Signaling Pathways Beyond Phosphatidylinositol 3–kinase–Mediating Glucose Transport and Lipogenesis
- Insulin‐stimulated cell growth in insulin receptor substrate‐1–deficient ZR‐75‐1 cells is mediated by a Phosphatidylinositol‐3‐kinase–independent pathway
- Down regulation of the expression of the p110, p85 and p55 subunits of Phosphatidylinositol 3–kinase during colon cancer cell anchorage-independent growth.
- c-Src and Phosphatidylinositol 3–kinase are involved in NGF-dependent tyrosine phosphorylation of Shc in PC12 cells
- Is stimulation of class-1 Phosphatidylinositol 3–kinase activity by insulin sufficient to activate pathways involved in glucose metabolism.
- Phenylarsine oxide inhibits insulin activation of Phosphatidylinositol 3′-kinase
- Interaction of insulin receptor substrate-1 (IRS-1) with Phosphatidylinositol 3–kinase: effect of substitution of serine for alanine in potential IRS-1 serine phosphorylation …
- Phosphorylation of the Grb2-and Phosphatidylinositol 3–kinase p85–binding p36/38 by Syk in Lck-Negative T Cells
- Tyrosine phosphorylation of Phosphatidylinositol 3–kinase and of the thromboxane A2 (TXA2) receptor by the TXA2 mimetic I-BOP in A7r5 cells
- … in neonatal rat ventricular myocytes by Ras is mediated by Ral guanine nucleotide dissociation stimulator (Ral. GDS) and Phosphatidylinositol 3–kinase in addition to …
- Effect of Ethanol on Intracellular Vesicular Transport from Golgi to the Apical Cell Membrane: Role of Phosphatidylinositol 3‐kinase and Phospholipase A2 in Golgi …
- Evidence that a kinase distinct from protein kinase C and Phosphatidylinositol 3–kinase mediates ligation-dependent serine/threonine phosphorylation of the T …
- Interleukin-4 (IL-4) induces Phosphatidylinositol 3–kinase (p85) dephosphorylation: implications for the role of SHP-1 in the IL-4-induced signals in human B …
- Inhibition of Kit expression by IL-4 and IL-10 in murine mast cells: role of STAT6 and Phosphatidylinositol 3′-kinase
- Phosphatidylinositol 3–kinase is required for the regulation of hepatitis B surface antigen production and mitogen-activated protein kinase activation by insulin but not …
- Formation of distinct signalling complexes involving Phosphatidylinositol 3‐kinase activity with stimulation of epidermal growth factor or insulin‐like growth factor‐I in …
- Secretory IgA-mediated basophil activation: II. Roles of GTP-binding regulatory proteins and Phosphatidylinositol 3–kinase
- Identification of protein kinase B (PKB) as a Phosphatidylinositol 3, 4, 5-trisphosphate binding protein in Dictyostelium discoideum
- Density dependent elevation of Phosphatidylinositol–3 kinase level in rat 3Y1 cells
- CD40-triggered protein tyrosine phosphorylation on Vav and on Phosphatidylinositol 3–kinase correlates with survival of the Ramos–Burkitt lymphoma B cell line
- Phosphatidylinositol 3–kinase translocation to the nucleus is an early event in the interleukin-1 signalling mechanism in human osteosarcoma Saos-2 cells.
- … and insensitive intracellular signalling pathways in undifferentiated 3T3‐L1 cells stimulated by insulin converge with Phosphatidylinositol 3‐kinase upstream of the …
- Phosphatidylinositol 3′-kinase is associated with a serine kinase that is activated by okadaic acid
- Phosphatidylinositol 3–kinase in Cumulus Cells is Responsible for Meiotic Progression from MI to M II Stage in Porcine Follicular Oocytes
- IL-2, but not IL-4 and other cytokines, induces phosphorylation of a 98-kDa protein associated with SHP-2, Phosphatidylinositol 3′-kinase, and Grb2
- … Nucleotide Exchange Factor and Ha-Ras: EVIDENCES FOR A FUNCTION OF Raf-1 AND Phosphatidylinositol 3–kinase UPSTREAM TO Ras
- … in tyrosine phosphorylation of insulin receptor and insulin receptor substrate-1 (IRS-1) and association of p85 subunit of Phosphatidylinositol 3–kinase with IRS-1 after …
- Polymorphism and CH… O interaction of wortmannin, a Phosphatidylinositol 3–kinase inhibitor
- … stimulation lowers the activation threshold and enhances the alloreactivity of cord blood T cells by activating the Phosphatidylinositol 3–kinase pathway and inducing …
- … ) and activating protein 1 (AP-1) by oncogenic 70Z Cbl requires an intact phosphotyrosine binding domain but not Crk (L) or p85 Phosphatidylinositol 3–kinase …
- Role of Phosphatidylinositol 3–kinase in platelet aggregation
- Down‐regulation of LFA‐1‐mediated T cell adhesion induced by the HIV envelope glycoprotein gp160 requires Phosphatidylinositol‐3‐kinase activity
- Phosphatidylinositol-4-phosphate 5-kinase isozymes catalyze the synthesis of 3-phosphate-containing Phosphatidylinositol signaling molecules
- … -(Hexadecyloxy)-3 (5)-Methoxybutanephosphonate (C4-PI), Inhibits Epithelial Cell Proliferation and is a Substrate but not an Inhibitor of Phosphatidylinositol 3–kinase
- Up-regulation of Phosphatidylinositol 3–kinase in psoriatic lesions
- … of connexin-43, gap junctional protein, in cumulus cells is regulated by mitogen-activated protein kinase and Phosphatidylinositol 3–kinase during in vitro meiotic …
- Inhibition of Phosphatidylinositol 3–kinase
- 1 , 25-Dihydroxyvitamin D 3–induced Myeloid Cell Differentiation Is Regulated by a Vitamin D Receptor–Phosphatidylinositol 3–kinase Signaling Complex
- Immunocytochemical detection of Phosphatidylinositol 3 kinase in Burkitt lymphoma cells
- Defect in long-term activation of Phosphatidylinositol 3–kinase by insulin in vivo: studies in insulin-resistant hHTg rats
- Hexamethylenebisacetamide modulation of thyroglobulin and protein levels in thyroid cells is not mediated by Phosphatidylinositol–3–kinase: A study with wortmannin
- The regulation and function of Phosphatidylinositol 3–kinase
- A role for Phosphatidylinositol 3–kinase in platelet aggregation
- Activation of the Phosphatidylinositol 3–kinase Serine kinase by 1FN-a’
- Phosphatidylinositol 3–kinase mediates interleukin-l-induced activation of NFB and AP-1 Shrikanth
- Regulation of the p85/p110 Phosphatidylinositol 3–kinase
- Through Phosphatidylinositol 3–kinase in Rat Heart
- Cloning and characterisation of novel isoforms of Phosphatidylinositol 3–kinase
- REGULATION OF CHOLANGIOCYTE CL SECRETION BY Phosphatidylinositol 3–kinase
- Bidirectional Effect of Regulatory Subunits of Phosphatidylinositol 3–kinase Dependent Signalling Pathway
- Role of Phosphatidylinositol 3–kinase as an effector of Ras
- Mechanism of radiation sensitization by wortmannin, a Phosphatidylinositol–3 kinase inhibitor
- Up-regulation of Phosphatidylinositol 3–kinase in psoriatic lesions
- Activation of Phosphatidylinositol 3–kinase via epidermal growth factor receptor in isolated rat hepatocytes
- Studies of a Phosphatidylinositol 3–kinase complex linked to vesicular trafficking in human cells
- Comparison of insulin and platelet-derived growth factor signaling: focusing on Phosphatidylinositol 3–kinase
- Activation of p70S6K and ERK as well as Akt by Heat Shock and Hyperosmorality Stress is Phosphatidylinositol 3–kinase Dependent
- Inhibition of proliferation by wortmannin through the blokade of Phosphatidylinositol 3–kinase in mast cell line P815
- Antagonists of Phosphatidylinositol 3–kinase block phosphorylation-dependent activation of the leukocyte NADPH oxidase in a cell-free system
- Phosphatidylinositol 3–kinase AND cAMP INVOLVEMENT IN THE GROWTH HORMONE REGULATION OF ION TRANSPORT IN CACO-2 CELLS
- Serendipitous studies in cell signaling: The role of Phosphatidylinositol 3–kinase (PI3K) in signal transduction, identification of new PI3K targets, and the …
- Activation of Phosphatidylinositol 3–kinase by interleukin-13 in colonic epithelial cells: regulation of nitric oxide and apoptosis
- Phosphatidylinositol–3 kinase dependent pathways: the role in control of cell growth, survival, and malignant transformation.
- Beclin–Phosphatidylinositol 3–kinase complex functions at the trans-Golgi network
- Phosphatidylinositol 3–kinase signaling controls levels of hypoxia-inducible factor
- New role for Shc in activation of the Phosphatidylinositol 3–kinase/Akt pathway
- Regulation of B-cell activation and differentiation by the Phosphatidylinositol 3–kinase and phospholipase Cgamma pathway.
- Phosphatidylinositol 3–kinase/AKT-mediated activation of estrogen receptor α: a new model for anti-estrogen resistance
- Phosphatidylinositol 3–kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endothelial cells
- Tyrosine phosphorylation of p85 relieves its inhibitory activity on Phosphatidylinositol 3–kinase
- A Phosphatidylinositol 3–kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus
- The Phosphatidylinositol 3′-kinase p85α gene is an oncogene in human ovarian and colon tumors
- Two Distinct Vps34 Phosphatidylinositol 3–kinase Complexes Function in Autophagy and Carboxypeptidase Y Sorting inSaccharomyces cerevisiae
- Regulation of neutrophil apoptosis: a role for protein kinase C and Phosphatidylinositol–3–kinase
- Ischemic preconditioning activates Phosphatidylinositol–3–kinase upstream of protein kinase C
- Role of Phosphatidylinositol 3–kinase-Akt pathway in nucleophosmin/anaplastic lymphoma kinase-mediated lymphomagenesis
- Phosphatidylinositol 3–kinase signaling inhibits DAF-16 DNA binding and function via 14-3–3-dependent and 14-3–3-independent pathways
- Phosphatidylinositol 3–kinase-dependent activation of trypsinogen modulates the severity of acute pancreatitis
- Phosphatidylinositol 3‐kinase mediates neuroprotection by estrogen in cultured cortical neurons
- Anti-apoptotic signaling by hepatocyte growth factor/Met via the Phosphatidylinositol 3–kinase/Akt and mitogen-activated protein kinase pathways
- Phosphatidylinositol 3–kinase regulates Raf1 through Pak phosphorylation of serine 338
- Transforming ability of MEN2A-RET requires activation of the Phosphatidylinositol 3–kinase/AKT signaling pathway
- Phosphatidylinositol 3–kinase as a mediator of TNF-induced NF-κB activation
- Expression of constitutively active Phosphatidylinositol 3–kinase inhibits activation of caspase 3 and apoptosis of cardiac muscle cells
- In Vivo and in Vitro Ovarian Carcinoma Growth Inhibition by a Phosphatidylinositol 3–kinase Inhibitor (LY294002)
- Opposing actions of Phosphatidylinositol 3‐kinase and glycogen synthase kinase‐3β in the regulation of HSF‐1 activity
- Phosphatidylinositol 3–kinase function is required for transforming growth factor β-mediated epithelial to mesenchymal transition and cell migration
- Substrate specificity of αvβ3integrin-mediated cell migration and Phosphatidylinositol 3–kinase/AKT pathway activation
- Role of reactive oxygen species and Phosphatidylinositol 3–kinase in cardiomyocyte differentiation of embryonic stem cells
- Phosphatidylinositol 3–kinase/Akt activity regulates c-FLIP expression in tumor cells
- The tumor suppressor PTEN positively regulates macroautophagy by inhibiting the Phosphatidylinositol 3–kinase/protein kinase B pathway
- The Phosphatidylinositol 3–kinase/AKT kinase pathway in multiple myeloma plasma cells: roles in cytokine-dependent survival and proliferative responses
- Myotubularin, a phosphatase deficient in myotubular myopathy, acts on Phosphatidylinositol 3–kinase and Phosphatidylinositol 3-phosphate pathway
- Insulin-like growth factor-mediated muscle differentiation: collaboration between Phosphatidylinositol 3–kinase-Akt-signaling pathways and myogenin
- The β2-Adrenergic Receptor Delivers an Antiapoptotic Signal to Cardiac Myocytes Through Gi-Dependent Coupling to Phosphatidylinositol 3′-kinase
- Phosphatidylinositol 3–kinase activity in epidermal growth factor-stimulated matrix metalloproteinase-9 production and cell surface association
- The osteopontin-CD44 survival signal involves activation of the Phosphatidylinositol 3–kinase/Akt signaling pathway
- Latent membrane protein 2A-mediated effects on the Phosphatidylinositol 3–kinase/Akt pathway
- The p75 neurotrophin receptor activates Akt (protein kinase B) through a Phosphatidylinositol 3–kinase-dependent pathway
- Pancreatic cancer cell proliferation is Phosphatidylinositol 3–kinase dependent
- Lipoarabinomannan from Mycobacterium tuberculosis promotes macrophage survival by phosphorylating Bad through a Phosphatidylinositol 3–kinase/Akt …
- Kit/stem cell factor receptor-induced activation of Phosphatidylinositol 3′-kinase is essential for male fertility
- Hypoxia activates a platelet-derived growth factor receptor/Phosphatidylinositol 3–kinase/Akt pathway that results in glycogen synthase kinase–3 inactivation
- Insulin rescues retinal neurons from apoptosis by a Phosphatidylinositol 3–kinase/Akt-mediated mechanism that reduces the activation of caspase-3
- Regulation of the protein kinase Raf-1 by oncogenic Ras through Phosphatidylinositol 3–kinase, Cdc42/Rac and Pak
- BCR/ABL regulates expression of the cyclin-dependent kinase inhibitor p27Kip1 through the Phosphatidylinositol 3–kinase/AKT pathway
- A novel role for Phosphatidylinositol 3–kinase β in signaling from G protein-coupled receptors to Akt
- Platelet-derived growth factor-induced H2O2 production requires the activation of Phosphatidylinositol 3–kinase
- Modulation of hypoxia-inducible factor 1α expression by the epidermal growth factor/Phosphatidylinositol 3–kinase/PTEN/AKT/FRAP pathway in human prostate …
- Regulation of melanogenesis through Phosphatidylinositol 3–kinase-Akt pathway in human G361 melanoma cells
- Hypoxia induces the activation of the Phosphatidylinositol 3–kinase/Akt cell survival pathway in PC12 cells: protective role in apoptosis
- Cytokines promote motoneuron survival through the Janus kinase-dependent activation of the Phosphatidylinositol 3–kinase pathway
- Nucleophosmin–anaplastic lymphoma kinase associated with anaplastic large-cell lymphoma activates the Phosphatidylinositol 3–kinase/Akt antiapoptotic signaling …
- A Phosphatidylinositol 3–kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor …
- Phosphatidylinositol 3 kinase contributes to the transformation of hematopoietic cells by the D816V c-Kit mutant
- α7 nicotinic receptor transduces signals to Phosphatidylinositol 3–kinase to block A β-amyloid-induced neurotoxicity
- The bile acid taurochenodeoxycholate activates a Phosphatidylinositol 3–kinase-dependent survival signaling cascade
- The hepatitis B virus-X protein activates a Phosphatidylinositol 3–kinase-dependent survival signaling cascade
- Phosphorylation of PDE3B by Phosphatidylinositol 3–kinase associated with the insulin receptor
- Phosphatidylinositol 3–kinase, not extracellular signal-regulated kinase, regulates activation of the antioxidant-responsive element in IMR-32 human …
- A specific function for Phosphatidylinositol 3–kinase α (p85α-p110α) in cell survival and for Phosphatidylinositol 3–kinase β (p85α-p110β) in de novo DNA synthesis of …
- Stimulation of Phosphatidylinositol 3–kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins
- Overexpression of Phosphatidylinositol 3–kinase in human lung cancer
- Angiopoietin-1 regulates endothelial cell survival through the Phosphatidylinositol 3′-kinase/Akt signal transduction pathway
- Restricted accumulation of Phosphatidylinositol 3–kinase products in a plasmalemmal subdomain during Fcγ receptor-mediated phagocytosis
- Inhibition of mitogen-activated protein kinase and Phosphatidylinositol 3–kinase activity in MCF-7 cells prevents estrogen-induced mitogenesis
- Role of Phosphatidylinositol 3–kinase and Rab5 effectors in phagosomal biogenesis and mycobacterial phagosome maturation arrest
- Roles of Phosphatidylinositol 3–kinase in interferon-γ-dependent phosphorylation of STAT1 on serine 727 and activation of gene expression
- Phosphatidylinositol 3–kinase is required for insulin-like growth factor-I–induced vascular smooth muscle cell proliferation and migration
- Association of Phosphatidylinositol 3–kinase with nuclear transcription sites in higher plants
- A novel positive feedback loop mediated by the docking protein Gab1 and Phosphatidylinositol 3–kinase in epidermal growth factor receptor signaling
- Human cytomegalovirus up-regulates the Phosphatidylinositol 3–kinase (PI3-K) pathway: inhibition of PI3-K activity inhibits viral replication and virus-induced signaling
- … endothelial growth factor induces expression of connective tissue growth factor via KDR, Flt1, and Phosphatidylinositol 3–kinase-akt-dependent pathways in …
- Signaling complexes and protein-protein interactions involved in the activation of the Ras and Phosphatidylinositol 3–kinase pathways by the c-Ret receptor …
- Hepatitis B virus X protein inhibits transforming growth factor-β-induced apoptosis through the activation of Phosphatidylinositol 3–kinase pathway
- Haptotactic migration induced by midkine: involvement of protein-tyrosine phosphatase ζ, mitogen-activated protein kinase, and Phosphatidylinositol 3–kinase
- The survival function of the Bcr-Abl oncogene is mediated by Bad-dependent and-independent pathways: roles for Phosphatidylinositol 3–kinase and Raf
- Interferon α/β promotes cell survival by activating nuclear factor κB through Phosphatidylinositol 3–kinase and Akt
- Angiopoietin-2 at high concentration can enhance endothelial cell survival through the Phosphatidylinositol 3′-kinase/Akt signal transduction pathway
- A Phosphatidylinositol 3–kinase/Akt pathway, activated by tumor necrosis factor or interleukin-1, inhibits apoptosis but does not activate NFκB in human …
- Induction of vascular endothelial growth factor receptors and Phosphatidylinositol 3′-kinase/Akt signaling by global cerebral ischemia in the rat
- … life span of skeletal muscle satellite cells by enhancing g1/s cell cycle progression via the activation of Phosphatidylinositol 3′-kinase/akt signaling pathway
- Phosphatidylinositol 3–kinase, Cdc42, and Rac1 act downstream of Ras in integrin-dependent neurite outgrowth in N1E-115 neuroblastoma cells
- Adrenomedullin induces endothelium-dependent vasorelaxation via the Phosphatidylinositol 3–kinase/Akt–dependent pathway in rat aorta
- Association of increased Phosphatidylinositol 3–kinase signaling with increased invasiveness and gelatinase activity in malignant gliomas
- Glycogen synthase kinase–3β activity is critical for neuronal death caused by inhibiting Phosphatidylinositol 3–kinase or Akt but not for death caused by nerve …
- The insulin-like growth factor-Phosphatidylinositol 3–kinase-Akt signaling pathway regulates myogenin expression in normal myogenic cells but not in …
- Phosphatidylinositol 3–kinase/Akt signaling controls endothelial cell sensitivity to Fas-mediated apoptosis via regulation of FLICE-inhibitory protein (FLIP)
- Inhibition of the Phosphatidylinositol 3–kinase pathway contributes to HT29 and Caco-2 intestinal cell differentiation
- A member of Forkhead family transcription factor, FKHRL1, is one of the downstream molecules of Phosphatidylinositol 3–kinase-Akt activation pathway in …
- Human SMG-1, a novel Phosphatidylinositol 3–kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the …
- Redistribution of Bruton’s tyrosine kinase by activation of Phosphatidylinositol 3‐kinase and Rho‐family GTPases
- Parallel and independent regulation of interleukin-3 mRNA turnover by Phosphatidylinositol 3–kinase and p38 mitogen-activated protein kinase
- Phosphatidylinositol 3–kinase C2α contains a nuclear localization sequence and associates with nuclear speckles
- The Phosphatidylinositol 3–kinase/AKT Signal Transduction Pathway Plays a Critical Role in the Expression of p21WAF1/CIP1/SDI1 Induced by Cisplatin and …
- Amino acid-induced translation of TOP mRNAs is fully dependent on Phosphatidylinositol 3–kinase-mediated signaling, is partially inhibited by rapamycin, and is …
- Nerve growth factor functions as a chemoattractant for mast cells through both mitogen-activated protein kinase and Phosphatidylinositol 3–kinase signaling pathways
- Role of Phosphatidylinositol 3′ kinase and a Downstream Pleckstrin Homology Domain–Containing Protein in Controlling Chemotaxis inDictyostelium
- Prevention of Phosphatidylinositol 3′-kinase-Akt survival signaling pathway during topotecan-induced apoptosis
- Signal transduction by the chemokine receptor CXCR3: activation of Ras/ERK, Src, and Phosphatidylinositol 3–kinase/Akt controls cell migration and …
- Oleate activates Phosphatidylinositol 3–kinase and promotes proliferation and reduces apoptosis of MDA-MB-231 breast cancer cells, whereas palmitate has opposite …
- Myogenic differentiation requires signalling through both Phosphatidylinositol 3–kinase and p38 MAP kinase
- Insulin-induced actin filament remodeling colocalizes actin with Phosphatidylinositol 3–kinase and GLUT4 in L6 myotubes
- … up-regulates vascular endothelial growth factor expression in human glioblastoma cells via a pathway involving Phosphatidylinositol 3′-kinase and distinct from that …
- Insulin Activates ATP-Sensitive K+ Channels in Pancreatic β-Cells Through a Phosphatidylinositol 3–kinase–Dependent Pathway
- Interferon-α promotes survival of human primary B-lymphocytes via Phosphatidylinositol 3–kinase
- … acetate induces neutrophil NADPH‐oxidase activity by two separate signal transduction pathways: dependent or independent of Phosphatidylinositol 3‐kinase
- The role of genetic abnormalities of PTEN and the Phosphatidylinositol 3–kinase pathway in breast and ovarian tumorigenesis, prognosis, and therapy
- Phosphatidylinositol 3–kinase inhibition enhances human sperm motility
- Extracellular zinc activates p70 S6 kinase through the Phosphatidylinositol 3–kinase signaling pathway
- Cooperative signaling between α6β4integrin and ErbB-2 receptor is required to promote Phosphatidylinositol 3–kinase-dependent invasion
- … -inducible factor (HIF)-1α, HIF-2α, and vascular endothelial growth factor expression and their regulation by the Phosphatidylinositol 3′-kinase/Akt signaling pathway
- α5β1 integrin protects intestinal epithelial cells from apoptosis through a Phosphatidylinositol 3–kinase and protein kinase B–dependent pathway
- Protein kinase C-ζ phosphorylates insulin receptor substrate-1 and impairs its ability to activate Phosphatidylinositol 3–kinase in response to insulin
- Cell cycle protein expression in vascular smooth muscle cells in vitro and in vivo is regulated through Phosphatidylinositol 3–kinase and mammalian target of …
- The EphA8 receptor regulates integrin activity through p110γ Phosphatidylinositol–3 kinase in a tyrosine kinase activity-independent manner
- The tyrosine phosphatase SHP-2 is required for mediating Phosphatidylinositol 3–kinase/Akt activation by growth factors
- Growth hormone induces cellular insulin resistance by uncoupling Phosphatidylinositol 3–kinase and its downstream signals in 3T3-L1 adipocytes
- … : Neuroprotection mediated by glial group‐II metabotropic glutamate receptors requires the activation of the MAP kinase and the Phosphatidylinositol‐3‐kinase …
- Scatter factor/hepatocyte growth factor protects against cytotoxic death in human glioblastoma via Phosphatidylinositol 3–kinase-and AKT-dependent pathways
- Cyclic AMP inhibits extracellular signal-regulated kinase and Phosphatidylinositol 3–kinase/Akt pathways by inhibiting Rap1
- The classical progesterone receptor associates with p42 MAPK and is involved in Phosphatidylinositol 3–kinase signaling inXenopus oocytes
- Cbl-b, a RING-type E3 ubiquitin ligase, targets Phosphatidylinositol 3–kinase for ubiquitination in T cells
- The inhibition of Phosphatidylinositol‐3‐kinase induces neurite retraction and activates GSK3
- Inhibitory mechanisms of tea polyphenols on the ultraviolet B-activated Phosphatidylinositol 3–kinase-dependent pathway
- Preconditioning enhanced glucose uptake is mediated by p38 MAP kinase not by Phosphatidylinositol 3–kinase
- Tec kinase signaling in T cells is regulated by Phosphatidylinositol 3–kinase and the Tec pleckstrin homology domain
- Trypanosoma cruzi: Phosphatidylinositol 3–kinase and protein kinase B activation is associated with parasite invasion
- A Phosphatidylinositol 3–kinase docking site in the cytoplasmic tail of the Jaagsiekte sheep retrovirus transmembrane protein is essential for envelope-induced …
- Phosphatidylinositol 3‐kinase and mTOR mediate lipopolysaccharide‐stimulated nitric oxide production in macrophages via interferon‐β
- Epstein-Barr virus immediate-early protein BRLF1 induces the lytic form of viral replication through a mechanism involving Phosphatidylinositol–3 kinase activation
- L-leucine availability regulates Phosphatidylinositol 3–kinase, p70 S6 kinase and glycogen synthase kinase–3 activity in L6 muscle cells: evidence for the involvement …
- Glycoprotein 130 regulates cardiac myocyte survival in doxorubicin-induced apoptosis through Phosphatidylinositol 3–kinase/Akt phosphorylation and Bcl-xL/caspase …
- Role of extracellular signal-regulated kinase and Phosphatidylinositol–3 kinase in chemoattractant and LPS delay of constitutive neutrophil apoptosis
- TNF-α-induced sphingosine 1-phosphate inhibits apoptosis through a Phosphatidylinositol 3–kinase/Akt pathway in human hepatocytes
- Activation of Phosphatidylinositol 3–kinase and Akt bytert-butylhydroquinone is responsible for antioxidant response element-mediated rGSTA2 induction in H4IIE cells
- Erythropoietin regulates vascular smooth muscle cell apoptosis by a Phosphatidylinositol 3 kinase-dependent pathway
- S338 phosphorylation of Raf-1 is independent of Phosphatidylinositol 3–kinase and Pak3
- … factor rapidly increases activity and cell surface expression of the EAAC1 subtype of glutamate transporter through activation of Phosphatidylinositol 3–kinase
- Oncogenic Ras blocks anoikis by activation of a novel effector pathway independent of Phosphatidylinositol 3–kinase
- Up-regulation of urokinase-type plasminogen activator by insulin-like growth factor-I depends upon Phosphatidylinositol–3 kinase and mitogen-activated protein …
- TEL-JAK2 mediates constitutive activation of the Phosphatidylinositol 3′-kinase/protein kinase B signaling pathway
- An inhibitory role of the Phosphatidylinositol 3–kinase-signaling pathway in vascular endothelial growth factor-induced tissue factor expression
- … fructose absorption by the extracellular signal-regulated kinase, p38 mitogen-activated kinase and Phosphatidylinositol 3–kinase intracellular signalling pathways …
- c-Src is required for glial cell line-derived neurotrophic factor (GDNF) family ligand-mediated neuronal survival via a Phosphatidylinositol–3 kinase (PI-3K)-dependent …
- … neurotrophic factor (BDNF) induces dendritic targeting of BDNF and tyrosine kinase B mRNAs in hippocampal neurons through a Phosphatidylinositol–3 kinase …
- Urokinase stimulates human vascular smooth muscle cell migration via a Phosphatidylinositol 3–kinase-Tyk2 interaction
- Phosphatidylinositol 3‐kinase and ERK are required for NF‐κB activation but not for phagocytosis
- Phosphatidylinositol 3–kinase potentiates, but does not trigger, T cell proliferation mediated by the IL-2 receptor
- Quercetin inhibits Shc-and Phosphatidylinositol 3–kinase-mediated c-Jun N-terminal kinase activation by angiotensin II in cultured rat aortic smooth muscle cells
- Differential effects of Phosphatidylinositol 3–kinase inhibition on intracellular signals regulating GLUT4 translocation and glucose transport
- Regulation of gene expression by glucose in pancreatic β-cells (MIN6) via insulin secretion and activation of Phosphatidylinositol 3′-kinase
- The essential role of Phosphatidylinositol 3–kinase and of p38 mitogen-activated protein kinase activation in the antioxidant response element-mediated rGSTA2 …
- Phosphatidylinositol 3–kinase signaling is important for smooth muscle cell replication after arterial injury
- Trypanosoma cruzi trans-sialidase: A potent and specific survival factor for human Schwann cells by means of Phosphatidylinositol 3–kinase/Akt signaling
- C5b-9 terminal complement complex protects oligodendrocytes from death by regulating Bad through Phosphatidylinositol 3–kinase/Akt pathway
- Putative role of the Phosphatidylinositol 3–kinase—Akt signaling pathway in the survival of granulosa cells
- Activation of Phosphatidylinositol–3 kinase (PI-3K) and extracellular regulated kinases (Erk1/2) is involved in muscarinic receptor-mediated DNA synthesis in neural …
- Insulin accelerates inter-endosomal GLUT4 traffic via Phosphatidylinositol 3–kinase and protein kinase B
- The Ras/Phosphatidylinositol 3–kinase and Ras/ERK pathways function as independent survival modules each of which inhibits a distinct apoptotic signaling …
- A Novel B Lymphocyte–associated Adaptor Protein, Bam32, Regulates Antigen Receptor Signaling Downstream of Phosphatidylinositol 3–kinase
- Involvement of the pathway Phosphatidylinositol–3–kinase/AKT-1 in the establishment of the survival response to ionizing radiation
- Reduction of potassium currents and Phosphatidylinositol 3–kinase-dependent AKT phosphorylation by tumor necrosis factor-α rescues axotomized retinal ganglion …
- Novel role of Phosphatidylinositol 3–kinase in CD28-mediated costimulation
- Hepatocyte growth factor protects cultured rat cerebellar granule neurons from apoptosis via the Phosphatidylinositol‐3 kinase/Akt pathway
- Halenaquinone, a novel Phosphatidylinositol 3–kinase inhibitor from a marine sponge, induces apoptosis in PC12 cells
- Stem cell factor induces Phosphatidylinositol 3′-kinase–dependent Lyn/Tec/Dok-1 complex formation in hematopoietic cells
- X-linked inhibitor of apoptosis protein activates the Phosphatidylinositol 3–kinase/Akt pathway in rat granulosa cells during follicular development
- Phosphatidylinositol–3 kinase and extracellular signal-regulated kinase mediate the chemotactic and mitogenic effects of insulin-like growth factor-I in human hepatic …
- Thapsigargin-induced degranulation of mast cells is dependent on transient activation of Phosphatidylinositol–3 kinase
- Phosphatidylinositol 3–kinase is necessary but not sufficient for thrombopoietin-induced proliferation in engineered Mpl-bearing cell lines as well as in primary …
- Specific requirement for the p85-p110α Phosphatidylinositol 3–kinase during epidermal growth factor-stimulated actin nucleation in breast cancer cells
- Cooperative regulation of Mcl-1 by Janus kinase/stat and Phosphatidylinositol 3–kinase contribute to granulocyte-macrophage colony-stimulating factor-delayed …
- Phosphatidylinositol–3 kinase acts in parallel to the ERK MAP kinase in the FGF pathway during Xenopus mesoderm induction
- Phosphatidylinositol 3′ kinase signaling in mammary tumorigenesis
- Neuregulin rescues PC12-ErbB4 cells from cell death induced by H2O2: regulation of reactive oxygen species levels by Phosphatidylinositol 3–kinase
- Apoptosis suppression by Raf-1 and MEK1 requires MEK-and Phosphatidylinositol 3–kinase-dependent signals
- Insulin regulates alternative splicing of protein kinase C βII through a Phosphatidylinositol 3–kinase-dependent pathway involving the nuclear serine/arginine …
- fMet-Leu-Phe stimulates proinflammatory cytokine gene expression in human peripheral blood monocytes: the role of Phosphatidylinositol 3–kinase
- Retention of PDGFR-β function in mice in the absence of Phosphatidylinositol 3′-kinase and phospholipase Cγ signaling pathways
- Activation of the Ral and Phosphatidylinositol 3′ kinase signaling pathways by the ras-related protein TC21
- The SH3 domain directs acto-myosin-dependent targeting of v-Src to focal adhesions via Phosphatidylinositol 3–kinase
- Caveolin 1-mediated regulation of receptor tyrosine kinase-associated Phosphatidylinositol 3–kinase activity by ceramide
- Phosphatidylinositol 3–kinase activation and interaction with focal adhesion kinase in Escherichia coli K1 invasion of human brain microvascular endothelial …
- Targets of B-cell antigen receptor signaling: the Phosphatidylinositol 3–kinase/Akt/glycogen synthase kinase–3 signaling pathway and the Rap1 GTPase.
- Regulation of Cyclin D1 Expression and DNA Synthesis by Phosphatidylinositol 3–kinase in Airway Smooth Muscle Cells
- Interleukin‐6 activates Phosphatidylinositol‐3 kinase, which inhibits apoptosis in human prostate cancer cell lines
- Cooperation between STAT5 and Phosphatidylinositol 3–kinase in the IL-3-dependent survival of a bone marrow derived cell line
- Endocytosis and nuclear trafficking of adeno-associated virus type 2 are controlled by rac1 and Phosphatidylinositol–3 kinase activation
- Phosphatidylinositol 3–kinase-dependent stabilization of α1(I) collagen mRNA in human lung fibroblasts
- GTPases and Phosphatidylinositol 3–kinase are critical for insulin-like growth factor-I-mediated Schwann cell motility
- The role of Phosphatidylinositol 3–kinase and the mitogen-activated protein kinases in insulin-like growth factor-I-mediated effects in vascular endothelial cells
- Thrombopoietin potentiates collagen receptor signaling in platelets through a Phosphatidylinositol 3–kinase–dependent pathway
- Regulation of intracellular trafficking of the EGF receptor by Rab5 in the absence of Phosphatidylinositol 3–kinase activity
- NK cell‐mediated lysis of autologous antigen‐presenting cells is triggered by the engagement of the Phosphatidylinositol 3‐kinase upon ligation of the natural …
- Role of Gab proteins in Phosphatidylinositol 3–kinase activation by thrombopoietin (Tpo)
- Phosphatidylinositol 3–kinase and NF-κB/Rel are at the divergence of CD40-mediated proliferation and survival pathways
- Distinct roles for extracellular-signal-regulated protein kinase (ERK) mitogen-activated protein kinases and Phosphatidylinositol 3–kinase in the regulation of Mcl-1 …
- … vascular endothelial cells by a phosphatase inhibitor: possible involvement of extracellular signal-regulated kinase and Phosphatidylinositol 3–kinase
- Growth hormone exerts antiapoptotic and proliferative effects through two different pathways involving nuclear factor-κB and Phosphatidylinositol 3–kinase
- Factor VIIa/tissue factor-induced signaling via activation of Src-like kinases, Phosphatidylinositol 3–kinase, and Rac
- … agonists increase expression of glutamate transporter GLT-1 in astrocytes through pathways dependent on Phosphatidylinositol 3–kinase and transcription factor NF …
- Both src-dependent and-independent mechanisms mediate Phosphatidylinositol 3–kinase regulation of colony-stimulating factor 1-activated mitogen-activated protein …
- Regulation of nuclear factor κB transactivation: implication of Phosphatidylinositol 3–kinase and protein kinase C ζ in c-Rel activation by tumor necrosis factor α
- Phosphatidylinositol 3‐kinase and the control of endosome dynamics: new players defined by structural motifs
- … of tyrosine residues in vascular endothelial growth factor receptor-2/FLK-1 involved in activation of Phosphatidylinositol 3–kinase and cell proliferation
- Tyr612 and Tyr632 in human insulin receptor substrate-1 are important for full activation of insulin-stimulated Phosphatidylinositol 3–kinase activity and translocation of …
- … of tyrosine residues in constitutively activated fibroblast growth factor receptor 3 involved in mitogenesis, Stat activation, and Phosphatidylinositol 3–kinase activation
- 1α, 25-Dihydroxyvitamin D3-induced monocyte antimycobacterial activity is regulated by Phosphatidylinositol 3–kinase and mediated by the NADPH …
- … effects of morphine in peroxynitrite-induced apoptosis of primary rat neonatal astrocytes: potential involvement of G protein and Phosphatidylinositol 3–kinase (PI3 …
- Phosphatidylinositol 3–kinase–dependent translocation of phospholipase Cγ2 in mouse megakaryocytes is independent of Bruton tyrosine kinase translocation
- Phosphatidylinositol 3–kinase-dependent extracellular calcium influx is essential for CX3CR1-mediated activation of the mitogen-activated protein kinase …
- Up-regulation of endothelial nitric-oxide synthase promoter by the Phosphatidylinositol 3–kinase γ/Janus kinase 2/MEK-1-dependent pathway
- … domain of Flt-1 (VEGFR-1) constitutively inhibits vascular endothelial growth factor-dependent Phosphatidylinositol 3′-kinase activation and endothelial cell …
- ErbB2-overexpressing human mammary carcinoma cells display an increased requirement for the Phosphatidylinositol 3–kinase signaling pathway in anchorage …
- Regulatory role of Phosphatidylinositol 3–kinase on TNF-α–Induced cyclooxygenase 2 expression in colonic epithelial cells
- Cytokines prevent dexamethasone-induced apoptosis via the activation of mitogen-activated protein kinase and Phosphatidylinositol 3–kinase pathways in a new …
- The Gab1 docking protein links the b cell antigen receptor to the Phosphatidylinositol 3–kinase/Akt signaling pathway and to the SHP2 tyrosine phosphatase
- Phosphatidylinositol 3–kinase mediates integrin-dependent NF-(κ) B and MAPK activation through separate signaling pathways
- Diversification of cardiac insulin signaling involves the p85α/β subunits of Phosphatidylinositol 3–kinase
- The expression of the p85α subunit of Phosphatidylinositol 3–kinase is induced by activation of the peroxisome proliferator-activated receptor γ in human adipocytes
- Stimulation of human neutrophils by chemotactic factors is associated with the activation of Phosphatidylinositol 3–kinase γ
- Roles of insulin receptor substrate-1, Phosphatidylinositol 3–kinase, and release of intracellular Ca2+ stores in insulin-stimulated insulin secretion in β-cells
- Differential regulation of the Phosphatidylinositol 3–kinase/Akt and p70 S6 kinase pathways by the α1A-adrenergic receptor in rat-1 fibroblasts
- Phosphatidylinositol 3–kinase, protein kinase B and ribosomal S6 kinases in the stimulation of thyroid epithelial cell proliferation by cAMP and growth factors in the …
- Src transduces erythropoietin-induced differentiation signals through Phosphatidylinositol 3–kinase
- Glial cell line-derived neurotrophic factor-stimulated Phosphatidylinositol 3–kinase and Akt activities exert opposing effects on the ERK pathway: importance …
- The bile acid–activated Phosphatidylinositol 3–kinase pathway inhibits Fas apoptosis upstream of bid in rodent hepatocytes
- Cross-talk between Phosphatidylinositol 3–kinase and sphingomyelinase pathways as a mechanism for cell survival/death decisions
- Reciprocal regulation of glycogen phosphorylase and glycogen synthase by insulin involving Phosphatidylinositol–3 kinase and protein phosphatase-1 in HepG2 cells
- Stimulation of tetrahydrobiopterin synthesis induced by insulin: possible involvement of Phosphatidylinositol 3–kinase
- Insulin-like growth factor (IGF) binding protein-3 potentiation of IGF action is mediated through the Phosphatidylinositol–3–kinase pathway and is associated with …
- Glut-1 Translocation in FRTL-5 Thyroid Cells: Role of Phosphatidylinositol 3–kinase and N-Glycosylation
- Persistent activation of Phosphatidylinositol 3–kinase causes insulin resistance due to accelerated insulin-induced insulin receptor substrate-1 degradation in 3T3-L1 …
- Five isoforms of the Phosphatidylinositol 3‐kinase regulatory subunit exhibit different associations with receptor tyrosine kinases and their tyrosine phosphorylations
- Phosphatidylinositol–3 kinase regulates p21ras activation during IgE-mediated stimulation of human basophils
- Ceramide regulates lipopolysaccharide-induced Phosphatidylinositol 3–kinase and Akt activity in human alveolar macrophages
- Insulin stimulates NHE1 activity by sequential activation of Phosphatidylinositol 3‐kinase and protein kinase C ζ in human erythrocytes
- Evidence for a Functional Association between Phosphatidylinositol 3–kinase and c-src in the Spreading Response of Osteoclasts to Colony-Stimulating Factor-1
- A Specific Role of Phosphatidylinositol 3–kinase γ: A Regulation of Autonomic Ca2+ Oscillations in Cardiac Cells
- Stabilization of cyclin D1 mRNA via the Phosphatidylinositol 3–kinase pathway in MCF-7 human breast cancer cells
- Protein phosphatase 2A and Phosphatidylinositol 3–kinase regulate the activity of Sp1-responsive promoters
- Tyrosine phosphorylation of the p85 subunit of Phosphatidylinositol 3–kinase correlates with high proliferation rates in sublines derived from the Jurkat leukemia
- Constitutively active Phosphatidylinositol 3–kinase and AKT are sufficient to stimulate the epithelial Na+/H+ exchanger 3
- Insulin-like growth factor-1 protects H9c2 cardiac myoblasts from oxidative stress-induced apoptosis via Phosphatidylinositol 3–kinase and extracellular signal …
- … protein phosphatase by insulin in vascular smooth muscle cells: evaluation of the role of Rho kinase and Phosphatidylinositol–3–kinase-dependent signaling pathways
- Phosphatidylinositol 3′-kinase blocks CD95 aggregation and caspase-8 cleavage at the death-inducing signaling complex by modulating lateral diffusion of CD95
- Platelet-derived growth factor activates porcine thecal cell Phosphatidylinositol–3–kinase-Akt/PKB and Ras-extracellular signal-regulated kinase-1/2 kinase signaling …
- Insulin-like growth factor I-induced degradation of insulin receptor substrate 1 is mediated by the 26S proteasome and blocked by Phosphatidylinositol 3′-kinase …
- 15-Deoxy-Δ12, 14-prostaglandin J2 and thiazolidinediones activate the MEK/ERK pathway through Phosphatidylinositol 3–kinase in vascular smooth muscle …
- Association of Phosphatidylinositol 3–kinase composed of p110β-catalytic and p85-regulatory subunits with the small GTPase Rab5
- Interleukins 4 and 13 increase intestinal epithelial permeability by a Phosphatidylinositol 3–kinase pathway: lack of evidence for STAT 6 involvement
- ERK regulates the hepatocyte growth factor-mediated interaction of Gab1 and the Phosphatidylinositol 3–kinase
- Intracellular signals that control cell proliferation in mammalian balance epithelia: key roles for Phosphatidylinositol–3 kinase, mammalian target of rapamycin, and S6 …
- Cutting edge: gab2 mediates an inhibitory Phosphatidylinositol 3′-kinase pathway in T cell antigen receptor signaling
- Brain‐derived neurotrophic factor induces excitotoxic sensitivity in cultured embryonic rat spinal motor neurons through activation of the Phosphatidylinositol 3‐kinase …
- Phosphatidylinositol 3–kinase signaling to Akt mediates survival in isolated canine islets of Langerhans
- … (VEGF) receptor-1 down-modulates VPF/VEGF receptor-2-mediated endothelial cell proliferation, but not migration, through Phosphatidylinositol 3–kinase …
- Involvement of a Phosphatidylinositol 3–kinase–p38 mitogen activated protein kinase pathway in antigen-induced IL-4 production in mast cells
- … growth factor/scatter factor stimulates migration of rat mammary fibroblasts through both mitogen‐activated protein kinase and Phosphatidylinositol 3‐kinase/Akt …
- Nerve Growth Factor Uses Ras/ERK and Phosphatidylinositol 3–kinase Cascades to Up-regulate theN-Methyl-d-aspartate Receptor 1 Promoter
- Glial cell line-derived neurotrophic factor promotes survival and induces differentiation through the Phosphatidylinositol 3–kinase and mitogen-activated protein kinase …
- A Phosphatidylinositol 3–kinase of Candida albicans influences adhesion, filamentous growth and virulence
- A link between insulin resistance and hyperinsulinemia: inhibitors of Phosphatidylinositol 3–kinase augment glucose-induced insulin secretion from islets of lean, but …
- Requirement of Phosphatidylinositol 3–kinase activity for translocation of exogenous aFGF to the cytosol and nucleus
- In vitro hormone induction of final oocyte maturation in striped bass (Morone saxatilis) follicles is inhibited by blockers of Phosphatidylinositol 3–kinase activity
- Tyrosine kinase-dependent, Phosphatidylinositol 3′-kinase, and mitogen-activated protein kinase-independent signaling pathways prevent lung adenocarcinoma …
- … preproinsulin gene expression and nucleartrans-location of pancreatic duodenum homeobox-1 require activation of Phosphatidylinositol 3–kinase but not p38 …
- Activation of Phosphatidylinositol 3‐kinase by a complex of p59fyn and the receptor tyrosine kinase Xmrk is involved in malignant transformation of pigment cells
- … protein-5 helps accelerate progression to androgen-independence in the human prostate LNCaP tumor model through activation of Phosphatidylinositol 3′-kinase …
- Dual Signaling via Protein kinase C and Phosphatidylinositol 3′-kinase/Akt Contributes to Bradykinin B2Receptor-induced Cardioprotection in Guinea Pig Hearts
- Insulin-like growth factor I potentiates kainate receptors through a Phosphatidylinositol 3–kinase dependent pathway
- Regulation of Id2 gene expression by the insulin-like growth factor I receptor requires signaling by Phosphatidylinositol 3–kinase
- Basic fibroblast growth factor stimulates surface expression and activity of Na+/H+ exchanger NHE3 via mechanism involving Phosphatidylinositol 3–kinase
- Aggretin, a C-type lectin protein, induces platelet aggregation via integrin α2β1 and GPIb in a Phosphatidylinositol 3–kinase independent pathway
- A molecular basis for T cell suppression by IL‐10: CD28‐associated IL‐10 receptor inhibits CD28 tyrosine phosphorylation and Phosphatidylinositol 3‐kinase binding
- Regulation of oxidative stress-induced calcium release by Phosphatidylinositol 3–kinase and Bruton’s tyrosine kinase in B cells
- Cyclooxygenase-2 inducing Mcl-1-dependent survival mechanism in human lung adenocarcinoma CL1. 0 cells: involvement of Phosphatidylinositol 3–kinase …
- Impaired muscle glycogen synthase in type 2 diabetes is associated with diminished Phosphatidylinositol 3–kinase activation
- … and luteinizing hormone in cultured porcine granulosa-luteal cells: possible convergence of protein kinase a, Phosphatidylinositol 3–kinase, and mitogen-activated …
- Role of Phosphatidylinositol 3–kinase and specific protein kinase B isoforms in the suppression of apoptosis mediated by the Abelson protein-tyrosine kinase
- The expression of the γ subunit of Na-K-ATPase is regulated by osmolality via C-terminal Jun kinase and Phosphatidylinositol 3–kinase-dependent mechanisms
- Ras activation of Phosphatidylinositol 3–kinase and Akt
- Involvement of Phosphatidylinositol 3–kinase and mitogen-activated protein kinases in glycine-extended gastrin-induced dissociation and migration of gastric …
- Direct interaction between the cytoplasmic tail of ADAM 12 and the Src homology 3 domain of p85α activates Phosphatidylinositol 3–kinase in C2C12 cells
- Regulation of epidermal growth factor receptor endocytosis by wortmannin through activation of Rab5 rather than inhibition of Phosphatidylinositol 3–kinase
- The insulin receptor substrate (IRS)-1 recruits Phosphatidylinositol 3–kinase to Ret: evidence for a competition between Shc and IRS-1 for the binding to Ret
- Activation of the Phosphatidylinositol 3–kinase-Akt/protein kinase B signaling pathway in arachidonic acid-stimulated human myeloid and endothelial cells …
- An SH2-domain-containing kinase negatively regulates the Phosphatidylinositol–3 kinase pathway
- The Phosphatidylinositol 3–kinase pathway selectively controls sIL-1RA not interleukin-1β production in the septic leukocytes
- T cell activation induces direct binding of the Crk adapter protein to the regulatory subunit of Phosphatidylinositol 3–kinase (p85) via a complex mechanism …
- Involvement of phospholipase D in sphingosine 1-phosphate-induced activation of Phosphatidylinositol 3–kinase and Akt in Chinese hamster ovary cells …
- The T cell antigen receptor activates Phosphatidylinositol 3‐kinase‐regulated serine kinases protein kinase B and ribosomal S6 kinase 1
- Rac and Phosphatidylinositol 3–kinase regulate the protein kinase B in FcεRI signaling in RBL 2H3 mast cells
- Activation of Phosphatidylinositol 3 kinase by muscarinic receptors in astrocytoma cells
- … with Thyrotropin-induced G1-S Transition Mediated by cAMP-dependent Protein kinase and Phosphatidylinositol 3–kinase: INVOLVEMENT OF RhoA AND …
- Expression of a constitutively active form of Phosphatidylinositol 3–kinase inhibits the induction of nitric oxide synthase in human astrocytes
- Role of Phosphatidylinositol 3–kinase in anti-IgM-and anti-IgD-induced apoptosis in B cell lymphomas
- Insulin-mediated cell proliferation and survival involve inhibition of c-Jun N-terminal kinases through a Phosphatidylinositol 3–kinase-and mitogen-activated protein …
- Enteric neuroblasts require the Phosphatidylinositol 3‐kinase pathway for GDNF‐stimulated proliferation
- The CK2 phosphorylation of vitronectin: Promotion of cell adhesion via the αvβ3–Phosphatidylinositol 3–kinase pathway
- β-Adrenergic stimulation of rat cardiac fibroblasts promotes protein synthesis via the activation of Phosphatidylinositol 3–kinase
- … 1 fusion protein of the t (6; 8) translocation induces cell survival mediated by mitogen-activated protein kinase and Phosphatidylinositol 3–kinase/Akt/mTOR pathways
- Ca2+-and Phosphatidylinositol 3–kinase-dependent nitric oxide generation in lung endothelial cells in situ with ischemia
- Compartmentalization and insulin-induced translocations of insulin receptor substrates, Phosphatidylinositol 3–kinase, and protein kinase B in rat liver
- Sites of action of protein kinase C and Phosphatidylinositol 3–kinase are distinct in oxidized low density lipoprotein-induced macrophage proliferation
- Role of Phosphatidylinositol–3 kinase and its association with Gab1 in thrombopoietin-mediated up-regulation of platelet function
- Heregulin‐β is especially potent in activating Phosphatidylinositol 3‐kinase in nontransformed human mammary epithelial cells
- Interaction of the insulin receptor β-subunit with Phosphatidylinositol 3–kinase in bovine ROS
- IL‐12 selectively regulates STAT4 via Phosphatidylinositol 3‐kinase and Ras‐independent signal transduction pathways
- Phosphatidylinositol 3–kinase stimulates muscle differentiation by activating p38 mitogen-activated protein kinase
- … rendered erythropoietin independent by infection with Friend spleen focus-forming virus show constitutive activation of Phosphatidylinositol 3–kinase and Akt kinase …
- Epidermal growth factor-induced Phosphatidylinositol 3–kinase activation and DNA synthesis: identification of Grb2-associated binder 2 as the major mediator …
- Platelet‐activating factor activates mitogen‐activated protein kinases through the activation of Phosphatidylinositol 3‐kinase and tyrosine kinase in human eosinophils
- Phosphatidylinositol 3–kinase is required for the trophic, but not the survival-promoting, actions of NGF on sympathetic neurons
- HIV‐1 Tat protein down‐regulates CREB transcription factor expression in PC12 neuronal cells through a Phosphatidylinositol 3‐kinase/AKT/cyclic nucleoside …
- LY 294002, an inhibitor of Phosphatidylinositol 3–kinase, inhibits GH-mediated expression of the IGF-I gene in rat hepatocytes
- Hck enhances the adherence of lipopolysaccharide-stimulated macrophages via Cbl and Phosphatidylinositol 3–kinase
- … apoptosis by crystals of calcium pyrophosphate dihydrate is mediated by the extracellular signal-regulated kinase and Phosphatidylinositol 3–kinase/Akt pathways up …
- Phosphatidylinositol 3–kinase confers resistance to encephalomyocarditis and herpes simplex virus-induced cell death through the activation of distinct downstream …
- Regulation of p85α Phosphatidylinositol–3–kinase expression by peroxisome proliferator-activated receptors (PPARs) in human muscle cells
- The Rho/Rho‐kinase and the Phosphatidylinositol 3‐kinase pathways are essential for spontaneous locomotion of Walker 256 carcinosarcoma cells
- Interactions between Phosphatidylinositol 3–kinase and nitric oxide: explaining the paradox
- The roles of Phosphatidylinositol 3–kinase and protein kinase Cζ for thrombopoietin-induced mitogen-activated protein kinase activation in primary murine …
- Inhibition of Phosphatidylinositol–3 kinase/Akt or mitogen-activated protein kinase signaling sensitizes endothelial cells to TNF-α cytotoxicity
- Activation of the Phosphatidylinositol 3–kinase/Akt pathway protects against interleukin-3 starvation but not DNA damage-induced apoptosis
- Enhanced cell killing by overexpression of dominant‐negative Phosphatidylinositol 3‐kinase subunit, Δp85, following genotoxic stresses
- … is required for efficient induction of chronic myeloid leukemia–like disease in mice but not for lymphoid leukemogenesis or activation of Phosphatidylinositol 3–kinase
- Phosphatidylinositol 3–kinase activity regulates α-thrombin-stimulated G1 progression by its effect on cyclin D1 expression and cyclin-dependent kinase 4 …
- … promotes the expression of peroxisome proliferator-activated receptor γ in vascular smooth muscle cells by a Phosphatidylinositol 3–kinase/Akt signaling pathway
- Mechanism of Phosphatidylinositol 3–kinase-dependent increases in BAC1. 2F5 macrophage-like cell density in response to M-CSF: Phosphatidylinositol 3–kinase …
- … effect of hepatocyte growth factor and fibronectin in anchorage-independent survival of mammary carcinoma cells: requirement for Phosphatidylinositol 3–kinase …
- Interleukin-6 protects rat PC12 cells from serum deprivation or chemotherapeutic agents through the Phosphatidylinositol 3–kinase and STAT3 pathways
- Phosphatidylinositol 3–kinase and Ras/mitogen-activated protein kinase signaling pathways are required for the regulation of 5-aminolevulinate synthase gene …
- Tyrosine kinase and Phosphatidylinositol 3–kinase activation are required for cyclic adenosine 3′, 5′-monophosphate-dependent potentiation of deoxyribonucleic …
- LFA-1-mediated costimulation of CD8+ T cell proliferation requires Phosphatidylinositol 3–kinase activity
- Phosphatidylinositol–3′ kinase-dependent vesicle formation in macrophages in response to macrophage colony stimulating factor
- A Phosphatidylinositol 3‐kinase of Candida albicans: molecular cloning and characterization
- Tyrosine phosphorylation is involved in Phosphatidylinositol 3–kinase activation in bovine rod outer segments
- Phosphatidylinositol 3–kinase-dependent pathways oppose fas-induced apoptosis and limit chloride secretion in human intestinal epithelial cells: implications …
- Phosphatidylinositol 3‐kinase activity is required for the expression of glial fibrillary acidic protein upon cAMP‐dependent induction of differentiation in rat C6 glioma
- Phosphatidylinositol 3–kinase in cumulus cells and oocytes is responsible for activation of oocyte mitogen-activated protein kinase during meiotic progression beyond …
- Neurotrophic factor protection against ethanol toxicity in rat cerebellar granule cell cultures requires Phosphatidylinositol 3–kinase activation
- Phosphatidylinositol 3–kinase activity in murine motoneuron disease: the progressive motor neuropathy mouse
- Phosphatidylinositol 3‐kinase Translocates to the Nucleus of Osteoblast‐Like MC3T3‐E1 Cells in Response to Insulin‐Like Growth Factor I and Platelet‐Derived …
- … a combined treatment with epidermal growth factor and transforming growth factor-β in rat hepatocytes: role of Phosphatidylinositol 3–kinase-induced AP-1 …
- Phosphatidylinositol 3–kinase is required for adherens junction-dependent mammary epithelial cell spheroid formation
- Role of Phosphatidylinositol 3–kinase in acetylcholine-induced dilatation of rat basilar artery
- … growth factor receptor 1 expressed in Xenopus laevis oocytes after fibroblast growth factor 1 addition: Role of Grb2, Phosphatidylinositol 3‐kinase, Src tyrosine kinase …
- Effect of long-term caloric restriction on GLUT4, Phosphatidylinositol–3 kinase p85 subunit, and insulin receptor substrate-1 protein levels in rhesus monkey skeletal …
- Phosphatidylinositol 3–kinase inhibitors, Wortmannin or LY294002, inhibited accumulation of p21 protein after γ-irradiation by stabilization of the protein
- Further evidence for the involvement of insulin receptor substrates in epidermal growth factor‐induced activation of Phosphatidylinositol 3‐kinase
- Rosiglitazone (BRL 49653) enhances insulin secretory response via Phosphatidylinositol 3–kinase pathway
- Anchorage-independent activation of mitogen-activated protein kinase through Phosphatidylinositol–3 kinase by insulin-like growth factor I
- Regulation of gene expression during severe caloric restriction: lack of induction of p85alpha Phosphatidylinositol 3–kinase mRNA in skeletal muscle of patients with …
- Tyrosine phosphorylation of the catalytic subunit p110 of Phosphatidylinositol–3 kinase induced by HMG-CoA reductase inhibitor inhibits its kinase activity in …
- Hepatocyte growth factor-induced differential activation of phospholipase Cγ1 and Phosphatidylinositol 3–kinase is regulated by tyrosine phosphatase SHP-1 …
- MIP-1α induces activation of Phosphatidylinositol–3 kinase that associates with Pyk-2 and is necessary for B-cell migration
- Phosphatidylinositol–3–kinase activation and atypical protein kinase C ζ phosphorylation characterize the DMSO signalling in erythroleukemia cells
- Inhibition of Phosphatidylinositol 3–kinase and protein kinase C attenuates extracellular matrix protein-induced vascular smooth muscle cell chemotaxis
- Phosphatidylinositol 3‐kinase inhibitors prevent mouse cytotoxic T‐cell development in vitro
- Phosphatidylinositol 3′-kinase-mediated calcium mobilization regulates chemotaxis in phosphatidic acid-stimulated human neutrophils
- Membrane depolarization-mediated survival of sympathetic neurons occurs through both Phosphatidylinositol 3–kinase-and CaM kinase II-dependent pathways
- Involvement of insulin receptor substrates in epidermal growth factor induced activation of Phosphatidylinositol 3‐kinase in rat hepatocyte primary culture
- Surfactant protein A regulates pulmonary surfactant secretion via activation of Phosphatidylinositol 3–kinase in type II alveolar cells
- Subcellular localization of insulin receptor substrate family proteins associated with Phosphatidylinositol 3–kinase activity and alterations in lipolysis in primary mouse …
- Phosphatidylinositol 3–kinase in zymosan-and bacteria-induced signalling to mobilisation of arachidonic acid in macrophages
- A human class II MHC–derived peptide antagonizes Phosphatidylinositol 3–kinase to block IL-2 signaling
- Induction of Phosphatidylinositol 3–kinase and serine-threonine kinase-like immunoreactivity in rabbit spinal cord after transient ischemia
- Phosphorylation of unnatural Phosphatidylinositols with Phosphatidylinositol 3–kinase
- Hepatic glutamine transporter activation in burn injury: role of amino acids and Phosphatidylinositol–3–kinase
- VCAM-1 activates Phosphatidylinositol 3–kinase and induces p120Cbl phosphorylation in human airway smooth muscle cells
- Inhibition of Phosphatidylinositol 3–kinase or Mitogen-Activated Protein kinase kinase Leads to Suppression of p34cdc2 kinase Activity and Meiotic Progression …
- DNA Damage-Induced G1 Arrest in Hematopoietic Cells Is Overridden following Phosphatidylinositol 3–kinase-Dependent Activation of Cyclin-Dependent kinase 2
- Phosphatidylinositol 3–kinase and trypsin activation in pancreatitis
- Expression of a prenylation-deficient Rab4 inhibits the GLUT4 translocation induced by active Phosphatidylinositol 3–kinase and protein kinase B
- … induction of tissue inhibitors of metalloproteinase-1 expression and secretion is mediated by mitogen-activated protein kinase and Phosphatidylinositol 3–kinase …
- Interaction of oestrogen receptor with the regulatory subunit of Phosphatidylinositol–3-OH kinase
- A direct interaction between oncogenic Ha-Ras and Phosphatidylinositol 3–kinase is not required for Ha-Ras-dependent transformation of epithelial cells
- … IV Collagen Interacts with a Novel Binding Site on the β3Subunit of Integrin αvβ3 and Stimulates Focal Adhesion kinase and Phosphatidylinositol 3–kinase …
- … 7, 8-tetrachlorodibenzo-p-dioxin (TCDD)-mediated aryl hydrocarbon receptor transformation and CYP1A1 induction by the Phosphatidylinositol 3–kinase inhibitor 2-(4 …
- The protein-tyrosine kinase fer associates with signaling complexes containing insulin receptor substrate-1 and Phosphatidylinositol 3–kinase
- Regulation of human neutrophil‐mediated cartilage proteoglycan degradation by Phosphatidylinositol‐3‐kinase
- … of the C/EBP homologous protein (CHOP) by amino acid deprivation requires insulin-like growth factor I, Phosphatidylinositol 3–kinase, and mammalian target of …
- Modulation of the basal activity of Phosphatidylinositol–3–kinase/protein kinase B signaling pathway in human hepatocarcinoma cells.
- Cytokine-stimulated T cells induce macrophage IL-10 production dependent on Phosphatidylinositol 3–kinase and p70S6K: implications for rheumatoid …
- Phosphatidylinositol 3–kinase in bovine lens and its stimulation by insulin and IGF-1
- Insulin activation of mitogen-activated protein (MAP) kinase and Akt is Phosphatidylinositol 3–kinase-dependent in rat adipocytes
- Inhibition of basophil histamine release by tyrosine kinase and Phosphatidylinositol 3–kinase inhibitors
- Stimulation of glycogen synthesis by insulin requires S6 kinase and Phosphatidylinositol‐3‐kinase in HTC‐IR cells
- Thrombin‐stimulated Phosphatidylinositol 3‐kinase activity in platelets is associated with activation of PYK2 tyrosine kinase: activation of both enzymes is aggregation …
- HIV-Nef enhances interleukin-2 production and Phosphatidylinositol 3–kinase activity in a human T cell line
- Exercise training prevents maturation-induced decreases in insulin receptor substrate-1 and Phosphatidylinositol 3–kinase in rat skeletal muscle
- Involvement of both Phosphatidylinositol 3–kinase and p44/p42 mitogen-activated protein kinase pathways in the short-term regulation of pyruvate kinase L by insulin
- Induction of Akt phosphorylation in rat primary astrocytes by H2O2 occurs upstream of Phosphatidylinositol 3–kinase: no evidence for oxidative inhibition of PTEN
- Gene encoding the catalytic subunit p110beta of human Phosphatidylinositol 3–kinase: cloning, genomic structure, and screening for variants in patients with type 2 …
- CD19 signal transduction in normal human B cells: linkage to downstream pathways requires Phosphatidylinositol 3‐kinase, protein kinase C and Ca2+
- Activation of Phosphatidylinositol 3–kinase by oxidative stress leads to the induction of microsomal epoxide hydrolase in H4IIE cells
- Direct identification of a major autophosphorylation site on vascular endothelial growth factor receptor Flt-1 that mediates Phosphatidylinositol 3′-kinase binding
- Rap1 is a potent activation signal for leukocyte function-associated antigen 1 distinct from protein kinase C and Phosphatidylinositol–3-OH kinase
- Phosphatidylinositol 3–kinase and protein kinase C contribute to the inhibition by interleukin 6 of phosphoenolpyruvate carboxykinase gene expression in cultured rat …
- Protein tyrosine kinase‐dependent regulation of adenylate cyclase and Phosphatidylinositol 3‐kinase activates the expression of glial fibrillary acidic protein upon …
- Odor-stimulated Phosphatidylinositol 3–kinase in lobster olfactory receptor cells
- 3-Deoxy-3-substituted-D-myo-inositol imidazolyl ether lipid phosphates and carbonate as inhibitors of the Phosphatidylinositol 3–kinase pathway and cancer cell …
- IL-10 inhibits apoptosis of promyeloid cells by activating insulin receptor substrate-2 and Phosphatidylinositol 3′-kinase
- Roles of Phosphatidylinositol 3‐kinase and phospholipase D in temporal activation of superoxide production in FMLP‐stimulated human neutrophils
- Association of Phosphatidylinositol 3–kinase with the insulin receptor: compartmentation in rat liver
- Prolactin signaling to pim-1 expression: a role for Phosphatidylinositol 3–kinase
- IGF-I stimulates chemotaxis of human neuroblasts. Involvement of type 1 IGF receptor, IGF binding proteins, Phosphatidylinositol–3 kinase pathway and plasmin …
- Interleukin‐10 and interleukin‐13 inhibit proinflammatory cytokine‐induced ceramide production through the activation of Phosphatidylinositol 3‐kinase
- Eicosanoid 12 (S)-HETE activates Phosphatidylinositol 3–kinase
- … receptor (CR2, CD21) on human B lymphocyte surface triggers tyrosine phosphorylation of the 95-kDa nucleolin and its interaction with Phosphatidylinositol 3 kinase
- Expression of Phosphatidylinositol–3 kinase in lung cancer
- Ca2+-evoked serotonin secretion by parafollicular cells: roles in signal transduction of Phosphatidylinositol 3′-kinase, and the γ and ζ isoforms of protein kinase C
- Activation of Phosphatidylinositol 3–kinase is required for transcriptional activity of F-type 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase: assessment of the …
- Dynamin inhibits Phosphatidylinositol 3–kinase in hematopoietic cells
- Evidence for the involvement of Phosphatidylinositol 3–kinase in fMLP-stimulated neutrophil adhesion to ICAM-1-transfected cells
- CRKII participation in the cellular effects of growth hormone and insulin-like growth factor-1: Phosphatidylinositol–3 kinase dependent and independent effects
- … library to identify basic residues in A-Raf required to mediate binding to the Src homology 2 domains of the p85 subunit of Phosphatidylinositol 3′-kinase
- Structural organization of the mouse Phosphatidylinositol 3–kinase p110d gene
- Involvement of tyrosine kinase and Phosphatidylinositol 3–kinase in phagocytosis by ascidian hemocytes
- Phosphatidylinositol 3–kinase modulates IL-18-induced nuclear factor-kappa B activation.
- … -induced glucose transport pathway in 3T3-L1 adipocytes is mediated by gab-1 and requires Gab-1-associated Phosphatidylinositol 3–kinase activity for full …
- Protein kinase C and Phosphatidylinositol 3–kinase independently contribute to P-glycoprotein-mediated drug secretion in the mouse proximal tubule
- Activation of NF-κB binding in HT-29 colon cancer cells by inhibition of Phosphatidylinositol 3–kinase
- Involvement of sphingomyelinase in insulin‐induced Phosphatidylinositol 3‐kinase activation
- Mitogenic signaling by cyclic adenosine monophosphate in chromaffin cells involves Phosphatidylinositol 3‐kinase activation
- … induces eukaryotic initiation factor 4E-binding protein 1 phosphorylation via a Ca2+-dependent pathway independent of Phosphatidylinositol 3–kinase/Akt
- … cascades initiated by fibroblast growth factor 1 on Xenopus oocytes expressing MDA-MB-231 mRNAs: role of Grb2, Phosphatidylinositol 3–kinase, Src tyrosine kinase …
- Activation of phospholipase D in porcine tracheal smooth muscle: role of Phosphatidylinositol 3–kinase and RhoA activation
- Role of the conserved acidic residue Asp21 in the structure of Phosphatidylinositol 3–kinase Src homology 3 domain: circular dichroism and nuclear magnetic …
- Inhibition of Phosphatidylinositol 3–kinase does not alter forskolin-stimulated Cl− secretion by T84 cells
- Modulation of the basal activity of N-acetylglucosaminyltransferase V by Phosphatidylinositol–3–kinase/protein kinase B signaling pathway in human hepatocarcinoma …
- … of IGF-I on type 2 nitric oxide synthase expression in Ins-1 cells and protection against activation-dependent apoptosis: involvement of Phosphatidylinositol 3–kinase.
- Regulation of the very late antigen‐4‐mediated adhesive activity of normal and nonreleaser basophils: roles for Src, Syk, and Phosphatidylinositol 3‐kinase
- Phosphatidylinositol 3–kinase and prostaglandylinositol cyclic phosphate (cyclic PIP), a mediator of insulin action, in the signal transduction of insulin
- Association of impaired Phosphatidylinositol 3–kinase activity in GLUT1-containing vesicles with malinsertion of glucose transporters into the plasma membrane of …
- Interactions of Phosphatidylinositol 3‐kinase Src homology 3 domain with its ligand peptide studied by absorption, circular dichroism, and UV resonance Raman …
- Cardiac insulin resistance is associated with an impaired recruitment of Phosphatidylinositol 3–kinase to GLUT4 vesicles.
- Glucosamine enhances platelet-derived growth factor-induced DNA synthesis via Phosphatidylinositol 3–kinase pathway in rat aortic smooth muscle cells
- Phosphatidylinositol‐3‐OH kinase regulatory subunits are differentially expressed during development of the rat cerebellum
- Grb-2-Associated Binder-1 Is Involved in Insulin-Induced egr-1 Gene Expression through its Phosphatidylinositol 3′-kinase Binding Site
- Identification of tyrosine residues involved in ligand recognition by the Phosphatidylinositol 3–kinase Src homology 3 domain: Circular dichroism and UV resonance …
- Sensitizing effect of the Phosphatidylinositol 3–kinase inhibitor wortmannin on thermal neutron irradiation with or without boron compound.
- Interleukin-1β Induced Synthesis of Protein kinase C-δ and Protein kinase C-ε in EL4 Thymoma Cells: Possible Involvement of Phosphatidylinositol 3–kinase
- In cardiomyocyte hypoxia, insulin-like growth factor-I-induced antiapoptotic signaling requires Phosphatidylinositol–3-OH-kinase-dependent and mitogen-activated …
- Ultrastructural modifications and Phosphatidylinositol–3–kinase expression and activity in myocardial tissue deriving from rats in different experimental conditions
- Troglitazone Enhances Glucose Uptake Induced By α‐Adrenoceptor Stimulation Via Phosphatidylinositol 3‐kinase In Rat Heart
- Involvement of regulating the Phosphatidylinositol 3–kinase signaling pathway in the process of herbimycin A-induced erythroid cell differentiation in the K562 …
- Phosphatidylinositol 3–kinase regulates proliferation of RAW 264.7 macrophages
- Regulation of cellular differentiation and cellular function by Phosphatidylinositol 3–kinase
- Up-regulation of Phosphatidylinositol–3 kinase Signaling in plcg1 Gene Null Fibroblasts.
- Tumor Necrosis Factor-α, Sphingomyelinase and Ceramides Activate Tyrosine kinase, P21ras and Phosphatidylinositol 3–kinase: Implications for Glucose Transport …
- Arginine-specific ADP-ribosyltransferase on the surface of gizzard smooth muscle cells and the involvement of Phosphatidylinositol 3–kinase in maintaining the activity …
- Casein kinase I associates with members of the centaurin-α family of Phosphatidylinositol 3, 4, 5-trisphosphate-binding proteins
- Glucose-induced insulin resistance of Phosphatidylinositol 3′-OH kinase and AKT/PKB is mediated by the hexosamine biosynthesis pathway
- TPO regulates Bcl-xL gene expression through Stat5 and Phosphatidylinositol–3–kinase activation pathways
- Wortmannin, A Specific Phosphatidylinositol 3–kinase Inhibitor, Blocks In Vitro Fertilization and Embryonic Development of Bovine Oocytes Matured In Vitro with …
- Activation of Phosphatidylinositol 3–kinase (PI3K) as a predictor of clinical outcome in breast cancer patients
- Phosphatidylinositol 3–kinase and NF
- The cloning and functional characterisation of murine Phosphatidylinositol 3–kinase gamma
- Phosphatidylinositol 3–kinase is involved in IL-18-stimulated AP-1 activation
- Investigation of Phosphatidylinositol–3–kinase (PI3K) and extracellular signal-regulated kinase 1/2 (ERK1/2) activation
- A novel mechanism of regulation of Phosphatidylinositol 3–kinase: Tyrosine phosphorylation of p85 residue 688
- A Role of Phosphatidylinositol 3–kinase (PI3K) on H-ras-lnduced Invasive phenotype
- The role and regulation of Phosphatidylinositol–3 kinase, PTEN, and AKT in tumorigenesis
- Rac and Phosphatidylinositol 3–kinase
- A Role of Phosphatidylinositol 3–kinase (PI3K) on H-ras-Induced Invasive phenotype
- The relationship of Met326Ile variant of p85? regulatory subunit of Phosphatidylinositol 3–kinase (PI3-K) with type 2 diabetes
- Phosphatidylinositol 3-OH kinase–Akt/protein kinase B pathway mediates Gas6 induction of scavenger receptor a in immortalized human vascular smooth muscle cell …
- Activation of Phosphatidylinositol 3–kinase (PI3K) is Required for Invasiveness and Motility in H-ras MCE10A Cells
- The Role of Nuclear Factor kB and Phosphatidylinositol 3–kinase in Trypsinogen Activation in Cerulein-Stimulated Rat Pancreatic Acini
- Phosphatidylinositol 3–kinase BUT NOT TUBERIN IS REQUIRED FOR PDGF-INDUCED CELL MIGRATION
- THE ESSENTIAL ROLE OF Phosphatidylinositol 3–kinase IN THE INDUCTION OF MICROSOMAL EPOXIDE HYDROLASE
- Role of Conserved Acidic Residue Asp21 in the Structure of Phosphatidylinositol 3–kinase Src Homology 3 Domain: Circular Dichroism and Nuclear Magnetic …
- Retinoic acid inhibits transformation by modulating Phosphatidylinositol 3–kinase signaling to the nucleus
- Regulation of hematopoietic cell proliferation by cytokine-activated Phosphatidylinositol 3–kinase
- Involvement of Phosphatidylinositol 3–kinase in the Insulin Signaling in Preimplantation Mouse Embryos
- Regulation of FRTL-5 thyroid cell growth by Phosphatidylinositol (OH) 3 kinase-dependent Akt-mediated signaling
- Expression of Phosphatidylinositol 3–kinase during the proliferation of the hypoxic rat pulmonary arterial smooth muscle cells
- Regulation of lysosomal pH in macrophages via Phosphatidylinositol 3–kinase and protein kinase C
- Activation of Phosphatidylinositol 3–kinase-protein kinase B (PI3K-PKB) induced by 17?-estradiol in endometrial carcinoma cell (Ishikawa)
- Cytokines Prevent Dexamethasone-induced Apoptosis via the Activation of Mitogen-activated Protein kinase and Phosphatidylinositol 3–kinase Pathways in a …
- An Inhibitory Role of the Phosphatidylinositol 3–kinase-signaling Pathway in Vascular Endothelial Growth Factor-induced Tissue Factor Expression
- c-CBL is the bridge molecule linking BCR/ABL to Phosphatidylinositol–3 kinase
- Fas and ceramide inhibition of the Phosphatidylinositol–3–kinase (PI3K) cell survival pathway in human granulosa luteal cells (hGLC).
- The Link between Insulin Resistance and Hyperinsulinemia: Inhibition of Phosphatidylinositol 3–kinase (PI3K) by Wortmannin Augments Glucose (G)-Induced Insulin …
- Wortmannin, A Specific Phosphatidylinositol 3–kinase Inhibitor, Blocks In Vitro Fertilization and Embryonic Development of Bovine Oocytes Matured In Vitro with …
- Lysophosphatidylcholine generates superoxide anions through activation of Phosphatidylinositol 3–kinase in human neutrophils
- Coincident signaling of cAMP with Phosphatidylinositol 3‘kinase and mitogen-activated protein kinase signal transduction cascades: A role in regulating gene …
- The role of nucleoside diphosphate kinase and Phosphatidylinositol 3–kinase in the expression and cellular localization of the glial fibrillary acidic protein …
- Insulin Regulates Alternative Splicing of Protein kinase C ßII through a Phosphatidylinositol 3–kinase-dependent Pathway Involving the Nuclear Serine …
- Evidence for Involvement of Gab-1 Associated Phosphatidylinositol 3–kinase in Osmotic Shock Induced Glucose Transport in 3T3-L1 Adipocytes
- Human SMG-1, a novel Phosphatidylinositol 3–kinase-related protein kinase, associates with components of the mRNA surveillance complex and involved in the …
- Aggretin, a C-Type Lectin Protein, Induces Platelet Aggregation Via Integrin 21 and Gpib in a Phosphatidylinositol 3–kinase Independent Pathway
- Interleukin-1 receptor associated kinase 1 and Phosphatidylinositol 3 kinase regulate the NF-kappaB activation induced by IL-1
- AtPIP5K1, an Arabidopsis thaliana Phosphatidylinositol phosphate kinase, synthesizes PtdIns (3, 4) P2 and PtdIns (4, 5) P2 in vitro and is inhibited by phosphorylation
- Role of the Phosphatidylinositol (PI) 3–kinase/Akt protein kinase signaling pathway in the survival of rat sympathetic neurons
- The Phosphatidylinositol 3–kinase–AKT pathway in human cancer
- Leading the way: directional sensing through Phosphatidylinositol 3–kinase and other signaling pathways
- Prostanoid receptors and Phosphatidylinositol 3–kinase: a pathway to cancer?
- Analysis of the Phosphatidylinositol 3′-kinase Signaling Pathway in Glioblastoma Patients in Vivo
- A crucial role for the p110δ subunit of Phosphatidylinositol 3–kinase in B cell development and activation
- Phosphatidylinositol–3 kinase inhibitors enhance the anti-leukemia effect of STI571
- The Phosphatidylinositol 3–kinase, p38, and extracellular signal-regulated kinase pathways are involved in osteoclast differentiation
- Rapid accumulation of Akt in mitochondria following Phosphatidylinositol 3‐kinase activation
- Inhibition of Phosphatidylinositol 3–kinase enhances mitogenic actions of insulin in endothelial cells
- The Phosphatidylinositol 3–kinase (PI3K)-Akt pathway suppresses Bax translocation to mitochondria
- Role of the Phosphatidylinositol 3–kinase/Akt and mTOR/P70S6-kinase pathways in the proliferation and apoptosis in multiple myeloma
- Role of the Phosphatidylinositol 3 kinase-Akt pathway in the regulation of IL-10 and IL-12 by Porphyromonas gingivalis lipopolysaccharide
- Anti-cancer alkyl-lysophospholipids inhibit the Phosphatidylinositol 3–kinase–Akt/PKB survival pathway
- The Phosphatidylinositol 3–kinase-Akt pathway limits lipopolysaccharide activation of signaling pathways and expression of inflammatory mediators in human …
- Inhibition of Phosphatidylinositol 3′-kinase Increases Efficacy of Paclitaxel in in Vitro and in Vivo Ovarian Cancer Models
- Phosphatidylinositol 3–kinase/Akt signaling in the response of vascular endothelium to ionizing radiation
- Role of the Phosphatidylinositol 3′-kinase/PTEN/Akt kinase pathway in the overexpression of fatty acid synthase in LNCaP prostate cancer cells
- Receptor-specific regulation of Phosphatidylinositol 3′-kinase activation by the protein tyrosine phosphatase Shp2
- A Phosphatidylinositol 3–kinase–phosphodiesterase 3B–cyclic AMP pathway in hypothalamic action of leptin on feeding
- Phosphatidylinositol 3‐kinase is involved in Toll‐like receptor 4‐mediated cytokine expression in mouse macrophages
- Src kinase mediates Phosphatidylinositol 3–kinase/Akt-dependent rapid endothelial nitric-oxide synthase activation by estrogen
- The role of focal adhesion kinase–Phosphatidylinositol 3–kinase-akt signaling in hepatic stellate cell proliferation and type I collagen expression
- Inhibition of the Phosphatidylinositol 3′-kinase-AKT Pathway Induces Apoptosis in Pancreatic Carcinoma Cells in Vitro and in Vivo
- Phosphatidylinositol 3–kinase mediates proliferative signals in intestinal epithelial cells
- Phosphatidylinositol 3–kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin
- Role of Phosphatidylinositol 3–kinase in oxidative stress-induced disruption of tight junctions
- Targeting the Phosphatidylinositol 3–kinase/Akt pathway for enhancing breast cancer cells to radiotherapy
- Phosphorylation of glycogen synthase kinase–3β during preconditioning through a Phosphatidylinositol–3–kinase–dependent pathway is cardioprotective
- Activation of fatty acid synthesis during neoplastic transformation: role of mitogen-activated protein kinase and Phosphatidylinositol 3–kinase
- Human mammary epithelial cell transformation through the activation of Phosphatidylinositol 3–kinase
- Phosphatidylinositol 3–kinase regulates the induction of long-term potentiation through extracellular signal-related kinase-independent mechanisms
- Regulation of hypoxia-inducible factor-1α protein level during hypoxic conditions by the Phosphatidylinositol 3–kinase/Akt/glycogen synthase kinase 3β …
- Role of translation initiation factor 2B in control of cell survival by the Phosphatidylinositol 3–kinase/Akt/glycogen synthase kinase 3β signaling pathway
- Constitutively activated Phosphatidylinositol–3 kinase (PI-3K) is involved in the defect of apoptosis in B-CLL: association with protein kinase Cδ
- Activation of the Phosphatidylinositol 3–kinase/protein kinase Akt pathway mediates nitric oxide-induced endothelial cell migration and angiogenesis
- Involvement of protein kinase C and Phosphatidylinositol 3–kinase pathways in the survival of B-cell chronic lymphocytic leukemia cells
- Phosphatidylinositol 3–kinase/Akt stimulates androgen pathway through GSK3β inhibition and nuclear β-catenin accumulation
- Suppression versus induction of androgen receptor functions by the Phosphatidylinositol 3–kinase/Akt pathway in prostate cancer LNCaP cells with different …
- Mutant epidermal growth factor receptor signaling down-regulates p27 through activation of the Phosphatidylinositol 3–kinase/Akt pathway in glioblastomas
- Normoxic induction of the hypoxia-inducible factor 1α by insulin and interleukin-1β involves the Phosphatidylinositol 3–kinase pathway
- Effects of deguelin on the Phosphatidylinositol 3–kinase/Akt pathway and apoptosis in premalignant human bronchial epithelial cells
- Native group‐III metabotropic glutamate receptors are coupled to the mitogen‐activated protein kinase/Phosphatidylinositol‐3‐kinase pathways
- … factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and Phosphatidylinositol 3–kinase signaling in colon …
- Phosphatidylinositol 3–kinase Functionally Compartmentalizes the Concurrent Gs Signaling During β2-Adrenergic Stimulation
- Modulation of Rab5 and Rab7 recruitment to phagosomes by Phosphatidylinositol 3–kinase
- Immunocytochemical detection of Phosphatidylinositol 3–kinase activation by insulin and leptin
- Activation of Phosphatidylinositol 3–kinase/Akt pathway by androgen through interaction of p85α, androgen receptor, and Src
- The endothelial receptor tyrosine kinase Tie1 activates Phosphatidylinositol 3–kinase and Akt to inhibit apoptosis
- Phosphatidylinositol 3–kinase interacts with the adaptor protein Dab1 in response to Reelin signaling and is required for normal cortical lamination
- Phosphatidylinositol 3–kinase: a molecule mediating BDNF-dependent spatial memory formation
- Phosphatidylinositol 3–kinase regulates nuclear translocation of NF-E2-related factor 2 through actin rearrangement in response to oxidative stress
- Endurance training improves responsiveness to insulin and modulates insulin signal transduction through the Phosphatidylinositol 3–kinase/Akt-1 pathway
- Activation of the Phosphatidylinositol 3–kinase/Akt signaling pathway by retinoic acid is required for neural differentiation of SH-SY5Y human neuroblastoma …
- Inhibition of Phosphatidylinositol 3–kinase-Akt signaling blocks growth, promotes apoptosis, and enhances sensitivity of small cell lung cancer cells to chemotherapy
- Src family protein-tyrosine kinases alter the function of PTEN to regulate Phosphatidylinositol 3–kinase/AKT cascades
- Herceptin-induced inhibition of Phosphatidylinositol–3 kinase and Akt Is required for antibody-mediated effects on p27, cyclin D1, and antitumor action
- Microphthalmia associated transcription factor is a target of the Phosphatidylinositol–3–kinase pathway
- Cannabinoids promote oligodendrocyte progenitor survival: involvement of cannabinoid receptors and Phosphatidylinositol–3 kinase/Akt signaling
- E-cadherin homophilic ligation directly signals through Rac and Phosphatidylinositol 3–kinase to regulate adhesive contacts
- Phosphatidylinositol 3–kinase is required for the expression but not for the induction or the maintenance of long-term potentiation in the hippocampal CA1 region
- Early expression of myocardial HIF-1α in response to mechanical stresses: regulation by stretch-activated channels and the Phosphatidylinositol 3–kinase signaling …
- Phosphatidylinositol 3–kinase/Akt signaling is neither required for hypoxic stabilization of HIF-1α nor sufficient for HIF-1-dependent target gene transcription
- Phosphatidylinositol 3–kinase redistribution is associated with skeletal muscle insulin resistance in gestational diabetes mellitus
- Phosphatidylinositol 3‐kinase is a central mediator of NMDA receptor signalling to MAP kinase (Erk1/2), Akt/PKB and CREB in striatal neurones
- Genomic copy number analysis of non-small cell lung cancer using array comparative genomic hybridization: implications of the Phosphatidylinositol 3–kinase …
- Requirement of BMP-2-induced Phosphatidylinositol 3–kinase and Akt serine/threonine kinase in osteoblast differentiation and Smad-dependent BMP-2 gene …
- Phosphatidylinositol 3–kinase regulates the CD4/CD8 T cell differentiation ratio
- Endocytosed transferrin receptors recycle via distinct dynamin and Phosphatidylinositol 3–kinase-dependent pathways
- Insulin activation of Phosphatidylinositol 3–kinase in the hypothalamic arcuate nucleus: a key mediator of insulin-induced anorexia
- Regulation of TRAIL expression by the Phosphatidylinositol 3–kinase/Akt/GSK-3 pathway in human colon cancer cells
- RANKL regulates endothelial cell survival through the Phosphatidylinositol 3′‐kinase/Akt signal transduction pathway
- Characterization of the Met326Ile variant of Phosphatidylinositol 3–kinase p85α
- Caveolin-induced activation of the Phosphatidylinositol 3–kinase/Akt pathway increases arsenite cytotoxicity
- Protective effect of dopamine D2 agonists in cortical neurons via the Phosphatidylinositol 3 kinase cascade
- Regulation of rat Sertoli cell function by FSH: possible role of Phosphatidylinositol 3–kinase/protein kinase B pathway
- Protective effects of docosahexaenoic acid in staurosporine‐induced apoptosis: involvement of Phosphatidylinositol‐3 kinase pathway
- Respiratory syncytial virus inhibits apoptosis and induces NF-κB activity through a Phosphatidylinositol 3–kinase-dependent pathway
- Role of the Phosphatidylinositol 3′-kinase/PTEN/Akt kinase pathway in tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in non-small cell …
- Aldosterone regulates vascular reactivity: short-term effects mediated by Phosphatidylinositol 3–kinase–dependent nitric oxide synthase activation
- ERK negatively regulates the epidermal growth factor-mediated interaction of Gab1 and the Phosphatidylinositol 3–kinase
- Vanadate-induced expression of hypoxia-inducible factor 1α and vascular endothelial growth factor through Phosphatidylinositol 3–kinase/Akt pathway and …
- Eph B4 receptor signaling mediates endothelial cell migration and proliferation via the Phosphatidylinositol 3–kinase pathway
- Critical involvement of the Phosphatidylinositol 3–kinase/Akt pathway in anchorage-independent growth and hematogeneous intrahepatic metastasis of liver cancer
- Cannabinoids protect astrocytes from ceramide-induced apoptosis through the Phosphatidylinositol 3–kinase/protein kinase B pathway
- Molecular basis of cell membrane estrogen receptor interaction with Phosphatidylinositol 3–kinase in endothelial cells
- … lethal effects of pharmacological cyclin-dependent kinase inhibitors in human leukemia cells proceed through a Phosphatidylinositol 3–kinase/Akt-dependent process
- Kaposi’s sarcoma-associated herpesvirus induces the Phosphatidylinositol 3–kinase-PKC-ζ-MEK-ERK signaling pathway in target cells early during infection …
- C5a delays apoptosis of human neutrophils by a Phosphatidylinositol 3–kinase-signaling pathway
- Phosphatidylinositol 3–kinase activity negatively regulates stability of cyclooxygenase 2 mRNA
- CD40 induces human multiple myeloma cell migration via Phosphatidylinositol 3–kinase/AKT/NF-κB signaling
- Ras mediates radioresistance through both Phosphatidylinositol 3–kinase-dependent and Raf-dependent but mitogen-activated protein kinase/extracellular signal …
- β1 integrin regulates fibroblast viability during collagen matrix contraction through a Phosphatidylinositol 3–kinase/Akt/protein kinase B signaling pathway
- … growth factor-induced migration of multiple myeloma cells is associated with β1 integrin-and Phosphatidylinositol 3–kinase-dependent PKCα activation
- Activated Gαq inhibits p110α Phosphatidylinositol 3–kinase and Akt
- Regulation of Fas expression by STAT3 and c-Jun is mediated by Phosphatidylinositol 3–kinase-AKT signaling
- Ureteric bud outgrowth in response to RET activation is mediated by Phosphatidylinositol 3–kinase
- … tumor cells can be overcome through restoration of PTEN function or pharmacologic modulation of constitutive Phosphatidylinositol 3′-kinase/Akt pathway signaling
- The role of Phosphatidylinositol 3‐kinase in neural cell adhesion molecule‐mediated neuronal differentiation and survival
- Reduced activation of Phosphatidylinositol–3 kinase and increased serine 636 phosphorylation of insulin receptor substrate-1 in primary culture of skeletal muscle …
- IL-12 provides proliferation and survival signals to murine CD4+ T cells through Phosphatidylinositol 3–kinase/Akt signaling pathway
- Regulation of Phosphatidylinositol 3–kinase activity and Phosphatidylinositol 3, 4, 5-trisphosphate accumulation by neutrophil priming agents
- Implication of Phosphatidylinositol 3–kinase membrane recruitment in hydrogen peroxide-induced activation of PI3K and Akt
- Phosphatidylinositol 3–kinase controls human intestinal epithelial cell differentiation by promoting adherens junction assembly and p38 MAPK activation
- Phosphatidylinositol 3–kinase Regulates Human Immunodeficiency Virus Type 1 Replication following Viral Entry in Primary CD4+ T Lymphocytes and Macrophages
- CD40-dependent activation of Phosphatidylinositol 3–kinase/Akt pathway mediates endothelial cell survival and in vitro angiogenesis
- The phospholipase Cγ1-dependent pathway of FcϵRI-mediated mast cell activation is regulated independently of Phosphatidylinositol 3–kinase
- Subversion of cell signaling pathways by hepatitis C virus nonstructural 5A protein via interaction with Grb2 and P85 Phosphatidylinositol 3–kinase
- IKKβ and Phosphatidylinositol 3–kinase/Akt participate in non-pathogenic Gram-negative enteric bacteria-induced RelA phosphorylation and NF-κB activation …
- The Phosphatidylinositol 3‐kinase inhibitor LY294002 potently blocks Kv currents via a direct mechanism
- Transduction of growth or mitogenic signals into translational activation of TOP mRNAs is fully reliant on the Phosphatidylinositol 3–kinase-mediated pathway but …
- … cell motility and nuclear factor κB-mediated secretion of urokinase type plasminogen activator through Phosphatidylinositol 3–kinase/Akt signaling pathways …
- Expression of a mutated form of the p85α regulatory subunit of Phosphatidylinositol 3–kinase in a Hodgkin’s lymphoma-derived cell line (CO)
- Brain-derived neurotrophic factor activation of TrkB protects neuroblastoma cells from chemotherapy-induced apoptosis via Phosphatidylinositol 3′-kinase pathway
- … of HER2 by ansamycins induces growth arrest and apoptosis in cells with HER2 overexpression via a HER3, Phosphatidylinositol 3′-kinase-AKT-dependent pathway
- … gene inactivation in mantle cell lymphoma mainly occurs by truncating mutations and missense mutations involving the Phosphatidylinositol–3 kinase domain and is …
- Inactivation of the antiapoptotic Phosphatidylinositol 3–kinase-Akt pathway by the combined treatment of taxol and mitogen-activated protein kinase kinase inhibition
- … -1 protects human breast epithelial cells against intrinsic apoptotic cell death via the focal adhesion kinase/Phosphatidylinositol 3–kinase and MAPK signaling …
- Phosphatidylinositol 3‐kinase coordinately activates the MEK/ERK and AKT/NFκB pathways to maintain osteoclast survival
- Negative regulation of Phosphatidylinositol 3–kinase and Akt signalling pathway by PKC
- The role of Phosphatidylinositol 3–kinase, rho family GTPases, and STAT3 in Ros-induced cell transformation
- Dysregulation of Phosphatidylinositol 3‐kinase and downstream effectors in human breast cancer
- Insulin down-regulates insulin receptor substrate-2 expression through the Phosphatidylinositol 3–kinase/Akt pathway
- Reciprocal modulation of Toll-like receptor-4 signaling pathways involving MyD88 and Phosphatidylinositol 3–kinase/AKT by saturated and polyunsaturated …
- Estrogen receptor alpha forms estrogen-dependent multimolecular complexes with insulin-like growth factor receptor and Phosphatidylinositol 3–kinase in the adult rat …
- Androgens stimulate hypoxia-inducible factor 1 activation via autocrine loop of tyrosine kinase receptor/Phosphatidylinositol 3′-kinase/protein kinase B in prostate …
- A Phosphatidylinositol 3–kinase-independent insulin signaling pathway to N-WASP/Arp2/3/F-actin required for GLUT4 glucose transporter recycling
- Hepatocyte growth factor induced human trophoblast motility involves Phosphatidylinositol–3–kinase, mitogen-activated protein kinase, and inducible nitric oxide …
- Evidence that SHIP-1 contributes to Phosphatidylinositol 3, 4, 5-trisphosphate metabolism in T lymphocytes and can regulate novel phosphoinositide 3–kinase …
- Insulin-like growth factor-I inhibits progesterone receptor expression in breast cancer cells via the Phosphatidylinositol 3–kinase/Akt/mammalian target of rapamycin …
- … hormone-treated astrocytes is mediated by epidermal growth factor/mitogen-activated protein kinase–Phosphatidylinositol 3–kinase pathways and involves …
- Cyclin-dependent kinase-5 is involved in neuregulin-dependent activation of Phosphatidylinositol 3–kinase and Akt activity mediating neuronal survival
- Interaction between Nef and Phosphatidylinositol–3–kinase leads to activation of p21-activated kinase and increased production of HIV
- Potential role of Phosphatidylinositol 3 kinase, rather than DNA-dependent protein kinase, in CpG DNA–induced immune activation
- p38 Mitogen‐activated protein kinase and Phosphatidylinositol 3‐kinase activities have opposite effects on human neutrophil apoptosis
- Activation of Phosphatidylinositol 3–kinase is important for erythropoietin-induced erythropoiesis from CD34+ hematopoietic progenitor cells
- PTEN and Phosphatidylinositol 3′-kinase inhibitors up-regulate p53 and block tumor-induced angiogenesis: evidence for an effect on the tumor and endothelial …
- Phosphatidylinositol 3–kinase and NF-κB regulate motility of invasive MDA-MB-231 human breast cancer cells by the secretion of urokinase-type plasminogen …
- The Role of Novel Oncogenes Squamous Cell Carcinoma-related Oncogene and Phosphatidylinositol 3–kinase p110α in Squamous Cell Carcinoma of the Oral …
- Signal transduction from N-cadherin increases Bcl-2: regulation of the Phosphatidylinositol 3–kinase/Akt pathway by homophilic adhesion and actin …
- Thrombopoietin regulates Bcl-xL gene expression through Stat5 and Phosphatidylinositol 3–kinase activation pathways
- Parallel Phosphatidylinositol–3 kinase and p42/44 mitogen-activated protein kinase signaling pathways subserve the mitogenic and antiapoptotic actions of insulin-like …
- CD28 and inducible costimulatory protein Src homology 2 binding domains show distinct regulation of Phosphatidylinositol 3–kinase, Bcl-xL, and IL-2 expression in …
- TAPP1 and TAPP2 are targets of Phosphatidylinositol 3–kinase signaling in B cells: sustained plasma membrane recruitment triggered by the B-cell antigen receptor
- Evidence that rheumatoid arthritis synovial T cells are similar to cytokine‐activated T cells: involvement of Phosphatidylinositol 3‐kinase and nuclear factor κB …
- Epstein-Barr virus latent membrane protein 1 (LMP1) activates the Phosphatidylinositol 3–kinase/Akt pathway to promote cell survival and induce actin filament …
- Ephrin-B2 induces migration of endothelial cells through the Phosphatidylinositol–3 kinase pathway and promotes angiogenesis in adult vasculature
- Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated Phosphatidylinositol 3–kinase activity in muscle
- Insulin-like growth factor-1 induces adhesion and migration in human multiple myeloma cells via activation of β1-integrin and Phosphatidylinositol 3′-kinase/AKT …
- Grb10 inhibits insulin-stimulated insulin receptor substrate (IRS)-Phosphatidylinositol 3–kinase/Akt signaling pathway by disrupting the association of IRS-1 …
- Synchronous activation of ERK and Phosphatidylinositol 3–kinase pathways is required for collagen and extracellular matrix production in keloids
- EGF receptor mediates adhesion-dependent activation of the Rac GTPase: a role for Phosphatidylinositol 3–kinase and Vav2
- Epidermal growth factor receptor-dependent, NF-κB-independent activation of the Phosphatidylinositol 3–kinase/Akt pathway inhibits ultraviolet irradiation …
- Sustained Production of H2O2Activates Pro-matrix Metalloproteinase-2 through Receptor Tyrosine kinases/Phosphatidylinositol 3–kinase/NF-κB Pathway
- Insulin stimulates hypoxia-inducible factor 1 through a Phosphatidylinositol 3–kinase/target of rapamycin-dependent signaling pathway
- Insulin-like growth factor-I inhibits transcriptional responses of transforming growth factor-β by Phosphatidylinositol 3–kinase/Akt-dependent suppression of the …
- … lucidum inhibits spontaneous and Fas‐mediated apoptosis in human neutrophils through activation of the Phosphatidylinositol 3 kinase/Akt signaling pathway
- Phosphatidylinositol 3 kinase regulates synapse specificity of hippocampal long-term depression
- Phosphatidylinositol–3–kinase–Akt kinase and p42/p44 mitogen-activated protein kinases mediate neurotrophic and excitoprotective actions of a secreted form of …
- … induces an autocrine‐paracrine survival pathway via platelet‐derived growth factor (PDGF)‐B/PDGF‐β receptor/Phosphatidylinositol 3‐kinase/Akt signaling in RN46A …
- Characterization of Phosphatidylinositol 3–kinase-dependent phosphorylation of the hydrophobic motif site Thr389 in p70 S6 kinase 1
- Insulin-Like Growth Factor-1–Induced Phosphorylation of Transcription Factor FKHRL1 Is Mediated by Phosphatidylinositol 3–kinase/Akt kinase and Role of This …
- Selective PDZ protein-dependent stimulation of Phosphatidylinositol 3–kinase by the adenovirus E4-ORF1 oncoprotein
- … endothelial growth factor induces protein kinase C (PKC)-dependent Akt/PKB activation and Phosphatidylinositol 3′-kinase-mediated PKCδ phosphorylation: role of …
- Augmentation of sodium butyrate-induced apoptosis by Phosphatidylinositol 3′-kinase inhibition in the KM20 human colon cancer cell line
- Phosphatidylinositol 3–kinase regulates PMA-induced differentiation and superoxide production in HL-60 cells
- … of FcϵRI‐and FcγRI‐mediated degranulation and TNF‐α synthesis in human mast cells: selective utilization of Phosphatidylinositol‐3‐kinase for FcγRI‐induced …
- The oncogene Phosphatidylinositol 3′-kinase catalytic subunit α promotes angiogenesis via vascular endothelial growth factor in ovarian carcinoma
- Tauroursodeoxycholic acid prevents amyloid-β peptide-induced neuronal death via a Phosphatidylinositol 3–kinase-dependent signaling pathway
- Functional cooperation among Ras, STAT5, and Phosphatidylinositol 3–kinase is required for full oncogenic activities of BCR/ABL in K562 cells
- … expression of the hypoxia marker MN/carbonic anhydrase IX in the absence of hypoxia-inducible factor 1α stabilization: a role for Phosphatidylinositol 3′-kinase
- Involvement of Phosphatidylinositol 3–kinase γ in neutrophil apoptosis
- Activation of Phosphatidylinositol 3–kinase contributes to insulin-like growth factor I-mediated inhibition of pancreatic β-cell death
- Inhibition of net HepG2 cell apolipoprotein B secretion by the citrus flavonoid naringenin involves activation of Phosphatidylinositol 3–kinase, independent of insulin …
- The Phosphatidylinositol 3–kinase/Akt signaling pathway modulates the endocrine differentiation of trophoblast cells
- Src and Phosphatidylinositol 3–kinase mediate soluble E-selectin–induced angiogenesis
- Dietary cod protein restores insulin-induced activation of Phosphatidylinositol 3–kinase/Akt and GLUT4 translocation to the T-tubules in skeletal muscle of high-fat-fed …
- Phosphatidylinositol 3–kinase but not tuberin is required for PDGF-induced cell migration
- Inhibition of Phosphatidylinositol 3–kinase sensitizes vascular endothelial cells to cytokine-initiated cathepsin-dependent apoptosis
- The growth arrest-specific gene product Gas6 promotes the survival of human oligodendrocytes via a Phosphatidylinositol 3–kinase-dependent pathway
- Macrophage-colony-stimulating factor-induced activation of extracellular-regulated kinase involves Phosphatidylinositol 3–kinase and reactive oxygen species in …
- The in Vitro and in Vivo Effects of 2-(4-Morpholinyl)-8-phenyl-chromone (LY294002), a Specific Inhibitor of Phosphatidylinositol 3′-kinase, in Human Colon Cancer …
- Essential Role of Phosphatidylinositol 3–kinase-Dependent CCAAT/Enhancer Binding Protein β Activation in the Induction of Glutathione S-Transferase by Oltipraz
- Betacellulin induces angiogenesis through activation of mitogen‐activated protein kinase and Phosphatidylinositol 3‘‐kinase in endothelial cells
- Oncogenic H-Ras Enhances DNA Repair through the Ras/Phosphatidylinositol 3–kinase/Rac1 Pathway in NIH3T3 Cells: Evidence for association with …
- Evidence for Phosphatidylinositol 3–kinase—Akt—p70S6K pathway activation and transduction of mitogenic signals by platelet-derived growth factor in human …
- Laminin-10/11 and fibronectin differentially prevent apoptosis induced by serum removal via Phosphatidylinositol 3–kinase/Akt-and MEK1/ERK-dependent …
- The Neuron-Specific Rai (ShcC) Adaptor Protein Inhibits Apoptosis by Coupling Ret to the Phosphatidylinositol 3–kinase/Akt Signaling Pathway
- … expression of early growth response factor-1 by EP4, but not EP2, prostanoid receptors via the Phosphatidylinositol 3–kinase and extracellular signal …
- Phosphatidylinositol 3–kinase Suppresses Glucose-Stimulated Insulin Secretion by Affecting Post-Cytosolic [Ca2+] Elevation Signals
- Requirement for Phosphatidylinositol–3 kinase activity during progression through S-phase and entry into mitosis
- Bile acid depletion and repletion regulate cholangiocyte growth and secretion by a Phosphatidylinositol 3–kinase–dependent pathway in rats
- The effects of lidocaine on the activity of glutamate transporter EAAT3: the role of protein kinase C and Phosphatidylinositol 3–kinase
- β-Arrestin1 mediates insulin-like growth factor 1 (IGF-1) activation of Phosphatidylinositol 3–kinase (PI3K) and anti-apoptosis
- Phosphatidylinositol 3–kinase, protein kinase C, and MEK1/2 kinase regulation of dopamine transporters (DAT) require N-terminal DAT phosphoacceptor sites
- Tumor necrosis factor alpha-induced interleukin-8 production via NF-κB and Phosphatidylinositol 3–kinase/Akt pathways inhibits cell apoptosis in human hepatocytes
- IL-13-induced changes in the goblet cell density of human bronchial epithelial cell cultures: MAP kinase and Phosphatidylinositol 3–kinase regulation
- … -cytokine cross-talk: the ELR+ CXC chemokine LIX (CXCl5) amplifies a proinflammatory cytokine response via a Phosphatidylinositol 3–kinase-NF-κB pathway
- Activation of vascular endothelial growth factor receptor-1 sustains angiogenesis and Bcl-2 expression via the Phosphatidylinositol 3–kinase pathway in endothelial …
- Nerve growth factor signals through TrkA, Phosphatidylinositol 3–kinase, and Rac1 to inactivate RhoA during the initiation of neuronal differentiation of PC12 …
- Semaphorin 3F antagonizes neurotrophin-induced Phosphatidylinositol 3–kinase and mitogen-activated protein kinase kinase signaling: a mechanism for growth cone …
- Phosphatidylinositol 3–kinase: a key regulator of vascular tone?
- Estrogen regulation of c-fos gene expression through Phosphatidylinositol–3–kinase-dependent activation of serum response factor in MCF-7 breast cancer cells
- Synapsin I-associated Phosphatidylinositol 3–kinase mediates synaptic vesicle delivery to the readily releasable pool
- Putative Phosphatidylinositol 3–kinase (PI3K) binding motifs in ovine betaretrovirus Env proteins are not essential for rodent fibroblast transformation and PI3K/Akt …
- Phosphatidylinositol 3–kinase is essential for the proliferation of lymphoblastoid cells
- Taurolithocholic acid exerts cholestatic effects via Phosphatidylinositol 3–kinase-dependent mechanisms in perfused rat livers and rat hepatocyte couplets
- The Phosphatidylinositol‐3 kinase (PI3K)‐Akt pathway suppresses neurite branch formation in NGF‐treated PC12 cells
- Involvement of Phosphatidylinositol 3–kinase, but not RalGDS, in TC21/R-Ras2-mediated transformation
- Interferon beta promotes survival in primary astrocytes through Phosphatidylinositol 3–kinase
- Role of Phosphatidylinositol 3–kinase/Akt pathway in angiotensin II and insulin-like growth factor-1 modulation of nitric oxide synthase in vascular smooth muscle cells
- Acetylcholine leads to free radical production dependent on KATP channels, Gi proteins, Phosphatidylinositol 3–kinase and tyrosine kinase
- Hepatitis B virus X protein activates a survival signaling by linking SRC to Phosphatidylinositol 3–kinase
- … sugar absorption is regulated by phosphorylation and turnover of protein kinase C βII mediated by Phosphatidylinositol 3–kinase-and mammalian target of …
- The α5β1 integrin selectively enhances epidermal growth factor signaling to the Phosphatidylinositol–3–kinase/Akt pathway in intestinal epithelial cells
- Src mediates prolactin-dependent proliferation of T47D and MCF7 cells via the activation of focal adhesion kinase/Erk1/2 and Phosphatidylinositol 3–kinase pathways
- Phosphatidylinositol 3–kinase and calcium-activated transcription pathways are required for VLDL-induced smooth muscle cell proliferation
- Estrogen enhances depolarization-induced glutamate release through activation of Phosphatidylinositol 3–kinase and mitogen-activated protein kinase in cultured …
- Regulatory role for SRC and Phosphatidylinositol 3–kinase in initiation of fibronectin matrix assembly
- TC21 mediates transformation and cell survival via activation of Phosphatidylinositol 3–kinase/Akt and NF-κB signaling pathway
- … CD44 interaction with RhoGEF and Rho kinase promotes Grb2-associated binder-1 phosphorylation and Phosphatidylinositol 3–kinase signaling leading to …
- Necessary role of Phosphatidylinositol 3‐kinase in transforming growth factor β–mediated activation of Akt in normal and rheumatoid arthritis synovial fibroblasts
- … motility and nuclear factor κB-mediated secretion of urokinase type plasminogen activator by inhibiting the Phosphatidylinositol 3′-kinase activity in breast …
- Attenuated 5‐HT1A receptor signaling in brains of suicide victims: involvement of adenylyl cyclase, Phosphatidylinositol 3‐kinase, Akt and mitogen‐activated protein …
- … nitric-oxide synthase by tumor necrosis factor-α: a novel pathway involving sequential activation of neutral sphingomyelinase, Phosphatidylinositol–3′ kinase, and …
- … cell line via a novel nongenomic mechanism involving the glucocorticoid receptor, protein kinase C, Phosphatidylinositol 3–kinase, and mitogen-activated protein …
- Phosphatidylinositol 3–kinase is a key regulator of early phase differentiation in keratinocytes
- Activation of Protein kinase C-ζ by Insulin and Phosphatidylinositol–3,4,5-(PO4)3 Is Defective in Muscle in Type 2 Diabetes and Impaired Glucose Tolerance …
- Evidence that Phosphatidylinositol 3–kinase-and mitogen-activated protein kinase kinase-4/c-Jun NH2-terminal kinase-dependent pathways cooperate to …
- Interleukin-3-mediated cell survival signals include Phosphatidylinositol 3–kinase-dependent translocation of the glucose transporter GLUT1 to the cell surface
- … growth factor I-mediated protection from rapamycin-induced apoptosis is independent of Ras-Erk1-Erk2 and Phosphatidylinositol 3′-kinase-Akt signaling pathways
- Requirement of Phosphatidylinositol 3–kinase activation and calcium influx for leukotriene B4-induced enzyme release
- Studies of the mitogen-activated protein kinases and Phosphatidylinositol–3 kinase in the lens. 1. The mitogenic and stress responses
- The cross-talk between angiotensin and insulin differentially affects Phosphatidylinositol 3–kinase-and mitogen-activated protein kinase-mediated signaling in rat heart …
- Impaired insulin action on Phosphatidylinositol 3–kinase activity and glucose transport in skeletal muscle of pancreatic cancer patients
- Etk/Bmx transactivates vascular endothelial growth factor 2 and recruits Phosphatidylinositol 3–kinase to mediate the tumor necrosis factor-induced angiogenic …
- Phosphatidylinositol 3′-kinase is required for growth of mast cells expressing the kit catalytic domain mutant
- Cell cycle activation in lung adenocarcinoma cells by the ErbB3/Phosphatidylinositol 3–kinase/Akt pathway
- HIV-1-Tat protein activates Phosphatidylinositol 3–kinase/AKT-dependent survival pathways in Kaposi’s sarcoma cells
- Activation of CR3‐mediated phagocytosis by MSP requires the RON receptor, tyrosine kinase activity, Phosphatidylinositol 3‐kinase, and protein kinase C ζ
- Insulin activates CCAAT/enhancer binding proteins and proinflammatory gene expression through the Phosphatidylinositol 3–kinase pathway in vascular …
- Insulin inhibits apoptosis of macrophage cell line, THP-1 cells, via Phosphatidylinositol–3–kinase–dependent pathway
- 1α,25-Dihydroxyvitamin D3 Induces Vascular Smooth Muscle Cell Migration via Activation of Phosphatidylinositol 3–kinase
- Phosphatidylinositol 3′-kinase-dependent activation of renal mesangial cell Ki-Ras and ERK by advanced glycation end products
- … -like growth factor-1 receptor activation inhibits oxidized LDL-induced cytochrome C release and apoptosis via the Phosphatidylinositol 3 kinase/Akt signaling pathway
- Phosphatidylinositol 3–kinase controls antineutrophil cytoplasmic antibodies—induced respiratory burst in human neutrophils
- Follicle-stimulating hormone promotes nuclear exclusion of the forkhead transcription factor FoxO1a via Phosphatidylinositol 3–kinase in porcine granulosa cells
- Role of Phosphatidylinositol 3‐kinase in neuronal survival and axonal outgrowth of adult mouse dorsal root ganglia explants
- μ-opioid receptor activation prevents apoptosis following serum withdrawal in differentiated SH-SY5Y cells and cortical neurons via Phosphatidylinositol 3–kinase
- Minimal mutation of the cytoplasmic tail inhibits the ability of E-cadherin to activate Rac but not Phosphatidylinositol 3–kinase: direct evidence of a role for …
- Dexamethasone impairs insulin signalling and glucose transport by depletion of insulin receptor substrate-1, Phosphatidylinositol 3–kinase and protein kinase B in …
- Regulation of the Phosphatidylinositol 3–kinase, Akt/protein kinase B, FRAP/mammalian target of rapamycin, and ribosomal S6 kinase 1 signaling pathways …
- The role of Phosphatidylinositol 3′-kinase and its downstream signals in erbB-2-mediated transformation
- Distinct role of Phosphatidylinositol 3–kinase and Rho family GTPases in Vav3-induced cell transformation, cell motility, and morphological changes
- … -like peptide-1 inhibits apoptosis of insulin-secreting cells via a cyclic 5′-adenosine monophosphate-dependent protein kinase A-and a Phosphatidylinositol 3–kinase …
- Phosphatidylinositol 3–kinase and Src family kinases are required for phosphorylation and membrane recruitment of Dok-1 in c-Kit signaling
- Early stage-specific inhibitions of cardiomyocyte differentiation and expression of Csx/Nkx-2.5 and GATA-4 by Phosphatidylinositol 3–kinase inhibitor LY294002
- Role of the insulin receptor substrate 1 and Phosphatidylinositol 3–kinase signaling pathway in insulin-induced expression of sterol regulatory element binding protein …
- High-fat diet and leptin treatment alter skeletal muscle insulin-stimulated Phosphatidylinositol 3–kinase activity and glucose transport
- … of interferon-γ-inducible GTPase inhibits coxsackievirus B3-induced apoptosis through the activation of the Phosphatidylinositol 3–kinase/Akt pathway and …
- Transformation of mouse fibroblasts by Jaagsiekte sheep retrovirus envelope does not require Phosphatidylinositol 3–kinase
- Y box-binding protein 1 induces resistance to oncogenic transformation by the Phosphatidylinositol 3–kinase pathway
- … growth factor protects against 6-hydroxydopamine-induced oxidative stress by increasing expression of heme oxygenase-1 in a Phosphatidylinositol 3–kinase …
- Phosphatidylinositol 3‐kinase is essential for kit ligand‐mediated survival, whereas interleukin‐3 and flt3 ligand induce expression of antiapoptotic Bcl‐2 family …
- Insulin Resistance, Defective Insulin Receptor Substrate 2—Associated Phosphatidylinositol–3′ kinase Activation, and Impaired Atypical Protein kinase C (ζ/λ) …
- Phosphatidylinositol 3–kinase may mediate isoproterenol-induced vascular relaxation in part through nitric oxide production
- Inhibition of activator protein-1 binding activity and Phosphatidylinositol 3–kinase pathway by nobiletin, a polymethoxy flavonoid, results in augmentation of tissue …
- B cell receptor-mediated Syk-independent activation of Phosphatidylinositol 3–kinase, Ras, and mitogen-activated protein kinase pathways
- High-resolution structure of the pleckstrin homology domain of protein kinase b/akt bound to Phosphatidylinositol (3, 4, 5)-trisphosphate
- Phosphatidylinositol 3–kinase activity is required for epidermal growth factor to suppress proteolysis
- A new role for the p85-Phosphatidylinositol 3–kinase regulatory subunit linking FRAP to p70 S6 kinase activation
- Phosphatidylinositol 3‐kinase and extracellular signal‐regulated kinase are recruited for Fc receptor‐mediated phagocytosis during monocyte‐to‐macrophage …
- Phosphatidylinositol 3–kinase in cumulus cells is responsible for both suppression of spontaneous maturation and induction of gonadotropin-stimulated …
- Inhibition of Phosphatidylinositol 3‐kinase and p70S6 kinase blocks osteogenic protein‐1 induction of alkaline phosphatase activity in fetal rat calvaria cells
- Neuroprotection by scatter factor/hepatocyte growth factor and FGF‐1 in cerebellar granule neurons is Phosphatidylinositol 3‐kinase/akt‐dependent and MAPK/CREB …
- Down-regulation of the Phosphatidylinositol 3–kinase/Akt pathway is involved in retinoic acid-induced phosphorylation, degradation, and transcriptional …
- … -mediated endocytosis and recycling of the neuron-specific Na+/H+ exchanger NHE5 isoform: regulation by Phosphatidylinositol 3′-kinase and the actin …
- Stretch-induced retinal vascular endothelial growth factor expression is mediated by Phosphatidylinositol 3–kinase and protein kinase C (PKC)-ζ but not by …
- Antagonism of rat β-cell voltage-dependent K+ currents by exendin 4 requires dual activation of the cAMP/protein kinase A and Phosphatidylinositol 3–kinase …
- Inhibition of Phosphatidylinositol 3‐kinase signaling negates the growth advantage imparted by a mutant epidermal growth factor receptor on human glioblastoma …
- Up-regulation of Phosphatidylinositol 3–kinase and glucose transporter 4 in muscle of rats subjected to maternal undernutrition
- AKT and the Phosphatidylinositol 3–kinase/AKT pathway: important molecular targets for lung cancer prevention and treatment
- Insulin inhibits extracellular regulated kinase 1/2 phosphorylation in a Phosphatidylinositol 3‐kinase (PI3) kinase‐dependent manner in Neuro2a cells
- Vascular endothelial growth factor causes pulmonary vasodilation through activation of the Phosphatidylinositol–3–kinase-nitric oxide pathway in the late …
- Src-Dependent Association of Cas and p85 Phosphatidylinositol 3′-kinase in v-crk-Transformed Cells
- Differential activation of Phosphatidylinositol 3–kinase signaling during proliferation and differentiation of lens epithelial cells
- … -1-Phosphate and Lysophosphatidic Acid Prevent Apoptosis in Osteoblastic Cells via a Signaling Pathway Involving Gi Proteins and Phosphatidylinositol–3 kinase
- Sphingosine-1-phosphate stimulates human glioma cell proliferation through Gi-coupled receptors: Role of ERK MAP kinase and Phosphatidylinositol 3–kinase β
- Purinergic P2Y12 receptor blockade inhibits shear-induced platelet Phosphatidylinositol 3–kinase activation
- Adrenomedullin reduces VEGF-induced endothelial adhesion molecules and adhesiveness through a Phosphatidylinositol 3′-kinase pathway
- Fibronectin enhances viability and alters cytoskeletal functions (with effects on the Phosphatidylinositol 3‐kinase pathway) in small cell lung cancer
- Phosphatidylinositol 3–kinase-dependent, MEK-independent proliferation in response to CaR activation
- Studies of the mitogen-activated protein kinases and Phosphatidylinositol–3 kinase in the lens. 2. The intercommunications
- Lipid rafts as the signaling scaffold for NK cell activation: tyrosine phosphorylation and association of LAT with Phosphatidylinositol 3‐kinase and phospholipase C‐γ …
- Noncatalytic domain of uPA stimulates human extravillous trophoblast migration by using phospholipase C, Phosphatidylinositol 3–kinase and mitogen-activated …
- Co-activation of the Phosphatidylinositol–3–kinase/Akt signaling pathway by N-methyl-D-aspartate and TrkB receptors in cerebellar granule cell neurons
- 1α, 25-dihydroxyvitamin D3 stimulates activator protein 1 DNA-binding activity by a Phosphatidylinositol 3–kinase/Ras/MEK/extracellular signal regulated …
- Selenite-induced survival of HuH7 hepatoma cells involves activation of focal adhesion kinase–Phosphatidylinositol 3–kinase-Akt pathway and Rac1
- Glucose-induced Phosphatidylinositol 3–kinase and mitogen-activated protein kinase-dependent upregulation of the platelet-derived growth factor-β receptor …
- Synthetic studies of the Phosphatidylinositol 3–kinase inhibitor LY294002 and related analogues
- … from PC12 Cells by Increasing Ca2+-Responsible Secretory Vesicles through the Activation of Mitogen-Activated Protein kinase and Phosphatidylinositol 3–kinase
- Phosphatidylinositol 3–kinase regulates bone morphogenetic protein-2 (BMP-2)-induced myocyte enhancer factor 2A-dependent transcription of BMP-2 gene …
- … TCRγδ+ and Vδ2+ TCRγδ+ T lymphocytes from healthy donors and multiple sclerosis patients: Involvement of Phosphatidylinositol 3 kinase and calcium calmodulin …
- Phosphatidylinositol 3–kinase and mek1/2 are necessary for insulin-like growth factor-I-induced vascular endothelial growth factor synthesis in prostate epithelial cells …
- … up-regulated uncoupling protein-1 expression is mediated by insulin receptor substrate 1 through the Phosphatidylinositol 3–kinase/Akt signaling pathway in …
- Pathogenic T cells in murine lupus exhibit spontaneous signaling activity through Phosphatidylinositol 3‐kinase and mitogen‐activated protein kinase pathways
- Growth factor receptor-binding protein 10 (Grb10) as a partner of Phosphatidylinositol 3–kinase in metabolic insulin action
- Phosphatidylinositol 3–kinase p85 adaptor function in T-cells: co-stimulation and regulation of cytokine transcription independent of associated p110
- Peroxynitrite activates NF-E2-related factor 2/antioxidant response element through the pathway of Phosphatidylinositol 3–kinase: the role of nitric oxide synthase in rat …
- BMP‐2 regulates cardiomyocyte contractility in a Phosphatidylinositol 3 kinase‐dependent manner
- Phosphatidylinositol 3–kinase in angiotensin II-induced hypertrophy of vascular smooth muscle cells
- Granulocyte-macrophage colony-stimulating factor signals for increased glucose transport via Phosphatidylinositol 3–kinase-and hydrogen peroxide …
- Autocrine signaling through Ras regulates cell survival activity in human glioma cells: potential cross-talk between Ras and the Phosphatidylinositol 3–kinase-Akt …
- Inhibition of the Phosphatidylinositol 3‘-kinase signaling pathway increases the responsiveness of pancreatic carcinoma cells to sulindac
- … factor/scatter factor inhibits UVB-induced apoptosis of human keratinocytes but not of keratinocyte-derived cell lines via the Phosphatidylinositol 3–kinase/AKT …
- Phosphatidylinositol 3‘-kinase and MAPK/ERK kinase 1/2 differentially regulate expression of vascular endothelial growth factor in human malignant astrocytoma cells
- The Phosphatidylinositol 3–kinase inhibitor LY294002 binds the estrogen receptor and inhibits 17β-estradiol-induced transcriptional activity of an estrogen sensitive …
- Inhibition of lymphocyte kinase Lck and Phosphatidylinositol 3–kinase by a novel immunosuppressant, lymphostin
- Role of Phosphatidylinositol 3‐kinase in the binding of Bordetella pertussis to human monocytes
- Human neutrophil-expressed CD28 interacts with macrophage B7 to induce Phosphatidylinositol 3–kinase-dependent IFN-γ secretion and restriction of Leishmania …
- … of a signature of interferon-γ-induced polypeptides that includes manganese-superoxide dismutase and the p85β subunit of Phosphatidylinositol 3–kinase
- Decay‐accelerating factor induction by tumour necrosis factor‐α, through a Phosphatidylinositol‐3 kinase and protein kinase C‐dependent pathway, protects murine …
- Platelet factor 4 inhibits FGF2-induced endothelial cell proliferation via the extracellular signal–regulated kinase pathway but not by the Phosphatidylinositol 3–kinase …
- Targeting of Mitogen-Activated Protein kinases and Phosphatidylinositol 3 kinase Inhibits Hepatocyte Growth Factor/Scatter Factor–Induced Angiogenesis
- Preferential binding of Grb2 or Phosphatidylinositol 3–kinase to the met receptor has opposite effects on HGF-induced myoblast proliferation
- Hypoxia protects human lung microvascular endothelial and epithelial-like cells against oxygen toxicity: role of Phosphatidylinositol 3–kinase
- … in human basophils by p38 mitogen‐activated protein kinase: phosphorylation is sensitive to the effects of Phosphatidylinositol 3‐kinase inhibitors and calcium …
- Inhibition of nuclear factor κB and Phosphatidylinositol 3‐kinase/Akt is essential for massive hepatocyte apoptosis induced by tumor necrosis factor α in mice
- … induces intracellular accumulation of multivesicular bodies and major histocompatibility complex class II complexes: potential role of Phosphatidylinositol 3–kinase
- Regulatory role of cAMP on expression of Cdk4 and p27Kip1 by inhibiting Phosphatidylinositol 3–kinase in corneal endothelial cells
- … ) tyrosine kinase phosphorylates and activates phosphoinositide-dependent kinase 1 (PDK1): an alternative Phosphatidylinositol 3–kinase-independent pathway to …
- … acid stimulates DNA synthesis in human microvascular endothelial cells via activation of Jak/STAT and Phosphatidylinositol 3–kinase/Akt signaling, leading to …
- Necessity of tyrosine 719 and Phosphatidylinositol 3′-kinase–mediated signal pathway in constitutive activation and oncogenic potential of c-kit receptor tyrosine …
- Recruitment of Phosphatidylinositol 3–kinase to CD28 inhibits HIV transcription by a Tat-dependent mechanism
- Calcium receptor-induced serotonin secretion by parafollicular cells: role of Phosphatidylinositol 3–kinase-dependent signal transduction pathways
- Motility enhancement by tumor-derived mutant E-cadherin is sensitive to treatment with epidermal growth factor receptor and Phosphatidylinositol 3–kinase inhibitors
- Phosphatidylinositol 3–kinase regulates glycosylPhosphatidylinositol hydrolysis through PLC-γ2 activation in erythropoietin-stimulated cells
- A new class of mutations reveals a novel function for the original Phosphatidylinositol 3–kinase binding site
- Involvement of Phosphatidylinositol 3–kinase in nuclear translocation of protein kinase C ζ induced by C2-ceramide in rat hepatocytes
- Enhancement of ischemia‐induced tyrosine phosphorylation of Kv1. 2 by vascular endothelial growth factor via activation of Phosphatidylinositol 3‐kinase
- Involvement of the Src kinase Lyn in phospholipase C-γ2 phosphorylation and Phosphatidylinositol 3–kinase activation in Epo signalling
- … granulocyte–macrophage colony‐stimulating factor and interleukin‐5, inhibits apoptosis of human basophils through Phosphatidylinositol 3‐kinase: requirement of NF …
- Insulin promotes formation of polymerized microtubules by a Phosphatidylinositol 3–kinase-independent, actin-dependent pathway in 3T3-L1 adipocytes
- … (EPO)-induced erythroid differentiation of K562 cells is accompanied by the nuclear translocation of Phosphatidylinositol 3–kinase and intranuclear generation of …
- Leptin constrains phospholipase C-protein kinase C-induced insulin secretion via a Phosphatidylinositol 3–kinase-dependent pathway
- β‐Adrenergic receptor‐mediated DNA synthesis in neonatal rat cardiac fibroblasts proceeds via a Phosphatidylinositol 3‐kinase dependent pathway refractory to the …
- Regulation of phospholipase C-γ2 via Phosphatidylinositol 3–kinase in macrophages
- Degradation of IκBα in activated RAW264. 7 cells is blocked by the Phosphatidylinositol 3–kinase inhibitor LY294002
- LY294002, an inhibitor of Phosphatidylinositol–3–kinase, causes preferential induction of apoptosis in human multidrug resistant cells
- Involvement of Phosphatidylinositol–3–kinase in membrane ruffling induced by P-glycoprotein substrates in multidrug-resistant carcinoma cells
- Aspirin protects Caco-2 cells from apoptosis after serum deprivation through the activation of a Phosphatidylinositol 3–kinase/AKT/p21Cip/WAF1pathway
- Lactate-induced translocation of GLUT1 and GLUT4 is not mediated by the Phosphatidylinositol–3–kinase pathway in the rat heart
- Insulin‐like growth factor‐1 rescues the mutated FGF receptor 3 (G380R) expressing ATDC5 cells from apoptosis through Phosphatidylinositol 3‐kinase and MAPK
- Insulin stimulates spreading of skeletal muscle cells involving the activation of focal adhesion kinase, Phosphatidylinositol 3‐kinase and extracellular signal regulated …
- Binding of Phosphatidylinositol 3, 4, 5-trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational change
- … -regulates the transcription of mouse lon homology ATP-dependent protease through extracellular signal-regulated protein kinase-and Phosphatidylinositol–3–kinase …
- Phosphatidylinositol 3–kinase-like activity in Tetrahymena. Effects of wortmannin and LY 294002
- Involvement of Phosphatidylinositol 3 kinase in the progesterone-induced oocyte maturation in Rana dybowskii
- Growth arrest of PC12 cells by nerve growth factor is dependent on the Phosphatidylinositol 3‐kinase/Akt pathway via p75 neurotrophin receptor
- … bad and glycogen synthase kinase–3 in a protein kinase A-dependent manner and prevents apoptosis following inhibition of Phosphatidylinositol 3–kinase
- Wortmannin, a specific inhibitor of Phosphatidylinositol–3–kinase influences neurotrophin-induced spiral ganglion neurite growth
- … -activated receptor gamma impedes Porphyromonas gingivalis lipopolysaccharide interference with salivary mucin synthesis through Phosphatidylinositol 3–kinase …
- External Qi of Yan Xin life science technology can revive or suppress enzyme activity of Phosphatidylinositol 3–kinase
- Matrix-independent activation of Phosphatidylinositol 3–kinase, Stat3, and cyclin A-associated Cdk2 Is essential for anchorage-independent growth of v-Ros …
- Phosphatidylinositol 3–kinase is required for insulin-stimulated tyrosine phosphorylation of Shc in 3T3-L1 adipocytes
- Transient ischemia enhances tyrosine phosphorylation and binding of the NMDA receptor to the Src homology 2 domain of Phosphatidylinositol 3‐kinase in the rat …
- Kit/stem cell factor receptor‐induced Phosphatidylinositol 3′‐kinase signalling is not required for normal development and function of interstitial cells of Cajal in …
- Cytoskeletal reorganization induced by insulin: involvement of Grb2/Ash, Ras and Phosphatidylinositol 3‐kinase signalling
- Selective pharmacological inhibitors reveal the role of Syk tyrosine kinase, phospholipase C, Phosphatidylinositol–3′-kinase, and p38 mitogen-activated protein …
- Phospholipase C and Phosphatidylinositol 3‐kinase signaling are involved in the exogenous arachidonic acid‐stimulated respiratory burst in human neutrophils
- Control of proteolysis by norepinephrine and insulin in brown adipocytes: role of ATP, Phosphatidylinositol 3–kinase, and p70 S6K
- … papillomavirus type 1 nucleotide 3225 3′ splice site can be rescued in a cell lacking splicing factor ASF/SF2 through activation of the Phosphatidylinositol 3–kinase …
- Gene expression of the p85α regulatory subunit of Phosphatidylinositol 3–kinase in skeletal muscle from type 2 diabetic subjects
- Detection of the p110 beta subunit of Phosphatidylinositol 3–kinase complexed with neutral endopeptidase.
- Phosphatidylinositol 3–kinase mediates inhibitory effect of angiotensin II on sodium/glucose cotransporter in renal epithelial cells
- Involvement of signaling through protein kinase C and Phosphatidylinositol 3–kinase in the excystation and metacystic development of Entamoeba invadens
- … of glial cell‐derived neurotrophic factor and cardiotrophin‐1 protects PC12 cells from injury: Involvement of the Phosphatidylinositol 3‐kinase and mitogen‐activated …
- α4 integrin signaling activates Phosphatidylinositol 3–kinase and stimulates T cell adhesion to intercellular adhesion molecule-1 to a similar extent as CD3, but …
- Prolongation of insulin-induced activation of mitogen-activated protein kinases ERK 1/2 and Phosphatidylinositol 3–kinase by vanadyl sulfate, a protein tyrosine …
- Cbl PYXXM motifs activate the P85 subunit of Phosphatidylinositol 3–kinase, Crk, atypical protein kinase C, and glucose transport during thiazolidinedione action in …
- An E2F-binding site mediates the activation of the proliferative isoform of 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase by Phosphatidylinositol 3–kinase
- Association between the Met326Ile Polymorphism of the p85α Regulatory Subunit of Phosphatidylinositol 3–kinase and Prostate Cancer Risk: A Prospective Study
- … coli K-1 interaction with human brain micro-vascular endothelial cells triggers phospholipase C-γ1 activation downstream of Phosphatidylinositol 3–kinase
- Exposure to asphalt fumes activates activator protein-1 through the Phosphatidylinositol 3–kinase/Akt signaling pathway in mouse epidermal cells
- … Ethanol on the Rat Glutamate Excitatory Amino Acid Transporter Type 3 Expressed in Xenopus Oocytes: Role of Protein kinase C and Phosphatidylinositol 3‐kinase
- Functional role of Phosphatidylinositol 3–kinase in direct tumor lysis by human natural killer cells
- Involvement of type I protein kinase A in the differentiation of L6 myoblast in conjunction with Phosphatidylinositol 3–kinase.
- … cell cycle progression through the synthesis of c-Myc protein by internal ribosome entry site–mediated translation via Phosphatidylinositol 3–kinase pathway in human …
- Src tyrosine kinase-induced loss of luteinizing hormone responsiveness is via a Ras-dependent, Phosphatidylinositol–3–kinase independent pathway
- A positive role of Phosphatidylinositol 3–kinase in aging phenotype expression in cultured human diploid fibroblasts
- Interleukin-2 receptors and interleukin-2-mediated signaling in myelin: activation of diacylglycerol kinase and Phosphatidylinositol 3–kinase
- Phosphatidylinositol 3–kinase Inhibitor Failed to Reduce Cerebral Vasospasm in Dog Model of Experimental Subarachnoid Hemorrhage
- Roles of tyrosine kinase–, 1-Phosphatidylinositol 3–kinase–, and mitogen-activated protein kinase–signaling pathways in ethanol-induced contractions of rat aortic …
- Activation and Phosphatidylinositol 3–kinase-dependent phosphorylation of protein kinase C-epsilon by the B cell antigen receptor
- Two modes of secretion in pancreatic acinar cells: involvement of Phosphatidylinositol 3–kinase and regulation by capacitative Ca2+ entry
- Lipidomic processes in homeostatic and LPS-modified cell renewal cycle. Role of Phosphatidylinositol 3–kinase pathway in biomembrane synthesis and restitution of …
- … pylori Lipopolysaccharide Interference with Gastric Mucin Synthesis by Peroxisome Proliferator‐Activated Receptor γ Activation Involves Phosphatidylinositol 3‐kinase …
- Defective Activation of Atypical Protein kinase C ζ and λ by Insulin and Phosphatidylinositol–3,4,5-(PO4)3 in Skeletal Muscle of Rats Following High-Fat Feeding and …
- Rosiglitazone reverses insulin secretion altered by chronic exposure to free fatty acid via IRS-2-associated Phosphatidylinositol 3–kinase pathway.
- α2 Adrenoceptor‐mediated vasoconstriction in porcine palmar lateral vein: role of Phosphatidylinositol 3‐kinase and EGF receptor transactivation
- … factor-beta mediated contraction of human dermal fibroblast populated lattices is inhibited by Rho/GTPase inhibitor but does not require Phosphatidylinositol–3‘kinase.
- ATP-sensitive K+ channel-mediated glucose uptake is independent of IRS-1/Phosphatidylinositol 3–kinase signaling
- Phosphatidylinositol‐3 kinase p85 enhances expression from the myelin basic protein promoter in oligodendrocytes
- Differential ligand recognition by the Src and Phosphatidylinositol 3–kinase Src homology 3 domains: circular dichroism and ultraviolet resonance Raman studies
- The role of Phosphatidylinositol 3–kinase (PI3K) in CO2 stimulation of the Na+/HCO3-cotransporter (NBC)
- Growth-inhibitory effect of Phosphatidylinositol 3–kinase inhibitor on human pancreatic cancer cells and expression of Bcl-2 family.
- Growth and Molecular Profile of Lung Cancer Cells Expressing Ectopic LKB1 Down-Regulation of the Phosphatidylinositol 3′-Phosphate kinase/PTEN Pathway
- ARNO but not cytohesin‐1 translocation is Phosphatidylinositol 3‐kinase‐dependent in HL‐60 cells
- Stimulated tyrosine phosphorylation of Phosphatidylinositol 3–kinase causes acidic pH-induced contraction in spontaneously hypertensive rat aorta
- Signal transducer and activator of transcription-3 and Phosphatidylinositol–3 kinase as coordinate regulators of melanoma cell response to glucocorticoid hormones
- Phosphatidylinositol–3 kinase-dependent activation of Akt does not correlate with either high mitogenicity or cell migration induced by FGF-1.
- The Phosphatidylinositol–3 kinase pathway is not essential for insulin-like growth factor I receptor-mediated clonogenic radioresistance
- PDGF stimulates DNA synthesis in human vascular smooth muscle cells via a novel wortmannin-insensitive Phosphatidylinositol 3–kinase
- Promoter polymorphisms− 359T/C and− 303A/G of the catalytic subunit p110β gene of human Phosphatidylinositol 3–kinase are not associated with insulin secretion …
- Co-operation of Phosphatidylinositol transfer protein with phosphoinositide 3–kinase g in vitro
- Activation of Phosphatidylinositol 3–kinase in human breast carcinoma
- Cell adhesion induces the plasminogen activator inhibitor-1 gene expression through Phosphatidylinositol 3–kinase/Akt activation in anchorage dependent cells
- Choline phosphate potentiates sphingosine-1-phosphate-induced Raf-1 kinase activation dependent of Ras–Phosphatidylinositol–3–kinase pathway
- In the article “Phosphatidylinositol 3–kinase Is Required for the Expression But Not for the Induction or the Maintenance of Long-Term Potentiation in the Hippocampal …
- … cultured with a fusion protein of insulin‐like growth factor II (IGF‐II) and interleukin 3 (IL‐3) is associated with increases in Bcl‐xL and Phosphatidylinositol‐3 kinase …
- Search for a molecular determinant in Phosphatidylinositol–3–kinase molecules, involved in the interaction with the beta-gamma-G protein dimer
- Expression of an active p110 catalytic subunit of Phosphatidylinositol 3‐kinase alters the proliferative capacity of interleukin‐2 receptor signals
- CD40 induces human multiple myeloma cell migration via Phosphatidylinositol 3–kinase/AKT/NF-B signaling
- Novel non-transcriptional mechanisms for estrogen receptor signaling in the cardiovascular system: Interaction of estrogen receptor α with Phosphatidylinositol 3-OH …
- Role of the Phosphatidylinositol 3 kinase-Akt
- TNF-alpha induced chondrocyte apoptosis in NF-κB suppression is augmented by inhibition of p38 mitogen-activated protein kinase or Phosphatidylinositol 3–kinase
- Defective Hyphal Induction of a Candida albicans Phosphatidylinositol 3-Phosphate 5-kinase Null Mutant on Solid Media Does Not Lead to Decreased Virulence
- The biological effect of the Phosphatidylinositol 3–kinase wortmannin following thermal neutron irradiation
- Acetylcholine-induced production of reactive oxygen species in adult rabbit ventricular myocytes is dependent on Phosphatidylinositol 3-and Src-kinase activation and …
- A Role for the Phosphatidylinositol–3–kinase Pathway in Preconditioning
- Roles of Phosphatidylinositol 3–kinase (PI3K) and Rac1
- Roles of Phosphatidylinositol 3–kinase (PI3K) and Rac 1
- Gene expression profile analysis of the Phosphatidylinositol 3–kinase pathway in the developing small intestine
- Defining the physiological role of Phosphatidylinositol 3–kinase protein kinase activity
- Characterisation of aggresome formation by the class III Phosphatidylinositol 3–kinase and its adaptor protein, p150.
- Class IA Phosphatidylinositol 3–kinase involvement in cytoskeletal regulation
- Novel age-associated induction of components of the Phosphatidylinositol–3 kinase (PI3K)/Akt signaling in the intestine
- TEL/platelet-derived growth factor receptor β activates Phosphatidylinositol 3 (PI3) kinase and requires PI3 kinase to regulate the cell cycle
- Negative regulation of transforming growth factorbeta/SMAD by Phosphatidylinositol 3–kinase pathway in neuroblastomas
- Investigating the effect of altered nutrition on signalling via Drosophila class 1A Phosphatidylinositol–3 kinase (PI3K), and functional analysis of PI3K mutated …
- Connective tissue growth factor inhibits apoptosis of human hypertrophic scar fibroblasts through Phosphatidylinositol 3–kinase/protein kinase B signal pathway
- Regulation of androgen receptor activity and degradation by the Phosphatidylinositol–3–kinase/Akt pathway, PTEN tumor suppressor, and Mdm2
- Epidermal growth factor-induced DNA synthesis: key roles for Phosphatidylinositol 3–kinase and the adaptor protein Gab2
- Requirement of BMP-2-induced Phosphatidylinositol 3–kinase and Akt serine/threonine kinase in osteoblast differentiation and Smad-dependent BMP-2 gene …
- In vivo administration of glucosamine inhibited Phosphatidylinositol 3–kinase activity without affecting tyrosine phosphorylation of the insulin receptor or insulin …
- Functional Cooperation among Ras, STAT5, and Phosphatidylinositol 3–kinase Is Required for Full Oncogenic Activities of BCR/ABL in K562 Cells
- Apoptosis of differentiated HL-60 cells induced by inhibitor of Phosphatidylinositol 3–kinase
- 1141. Insulin-Like Growth Factor-1 Enhances Plasmid Transgene Expression through a Phosphatidylinositol 3–kinase-Dependent Pathway
- Phosphatidylinositol (3, 4, 5) P3 is essential but not sufficient for protein kinase B (PKB) activation; Phosphatidylinositol (3, 4) P2 is required for PKB …
- DEFECTS IN INTERMEDIATE INSULIN SIGNALING IN SKELETAL MUSCLE: Phosphatidylinositol (PI) 3–kinase AND GLUCOSE TRANSPORT
- … CANCER: ANTIMONY VERSUS TECHNETIUM-99 FILTERED SULFUR COLLOID52. THE INVOLVEMENT OF Phosphatidylinositol 3–kinase (PI3-K)/AKT …
- Insulin activates CCAAT/enhancer binding proteins and proinflammatory gene expression through the Phosphatidylinositol 3–kinase pathway in vascular smooth …
- Phosphatidylinositol kinase enzymes regulate the retrograde axonal transport of NT‐3 and NT‐4 in sympathetic and sensory neurons
- The Role of Phosphatidylinositol 3‘-OH kinase Signaling in Mammary Tumorigenesis
- Epithelial–mesenchymal transition in development and cancer: role of Phosphatidylinositol 3′ kinase/AKT pathways
- The pivotal role of Phosphatidylinositol 3–kinase–Akt signal transduction in virus survival
- Phosphatidylinositol 3–kinase mutations identified in human cancer are oncogenic
- Targeting the Phosphatidylinositol–3 kinase/Akt pathway for the treatment of cancer.
- Inhibition of Rho-kinase leads to rapid activation of Phosphatidylinositol 3–kinase/protein kinase Akt and cardiovascular protection
- The prognostic significance of Phosphatidylinositol 3–kinase pathway activation in human gliomas
- Exercise activates the Phosphatidylinositol 3–kinase pathway
- Early involvement of the Phosphatidylinositol 3–kinase/Akt pathway in lung cancer progression
- Postconditioning: a form of “modified reperfusion” protects the myocardium by activating the Phosphatidylinositol 3–kinase-Akt pathway
- Cell type-specific expression of the IκB kinases determines the significance of Phosphatidylinositol 3–kinase/Akt signaling to NF-κB activation
- Type I transforming growth factor β receptor binds to and activates Phosphatidylinositol 3–kinase
- Phosphatidylinositol 3–kinase–Akt pathway plays a critical role in early cardiomyogenesis by regulating canonical Wnt signaling
- Regulation of Cu/Zn-superoxide dismutase expression via the Phosphatidylinositol 3 kinase/Akt pathway and nuclear factor-κB
- The Phosphatidylinositol‐3 kinase pathway regulates bladder cancer cell invasion
- Novel role for Na, K-ATPase in Phosphatidylinositol 3–kinase signaling and suppression of cell motility
- Inhibition of Phosphatidylinositol 3–kinase dephosphorylates BAD and promotes apoptosis in myeloid leukemias.
- … growth factor transcriptional activation is mediated by hypoxia-inducible factor 1α, HDM2, and p70S6K1 in response to Phosphatidylinositol 3–kinase/AKT …
- … metabolites stimulate endothelial cell growth and angiogenesis via mitogen-activated protein kinase and Phosphatidylinositol 3–kinase/Akt signaling pathways
- Focal adhesion kinase is upstream of Phosphatidylinositol 3–kinase/Akt in regulating fibroblast survival in response to contraction of type I collagen matrices …
- Pancreatic stellate cell migration: role of the Phosphatidylinositol 3–kinase (PI3–kinase) pathway
- Inhibition of the Phosphatidylinositol 3–kinase/Akt pathway by inositol pentakisphosphate results in antiangiogenic and antitumor effects
- Tobacco Carcinogen-Induced Cellular Transformation Increases Activation of the Phosphatidylinositol 3′-kinase/Akt Pathway in Vitro and in Vivo
- Phosphatidylinositol–3–kinase signaling is required for erythropoietin-mediated acute protection against myocardial ischemia/reperfusion injury
- Activation of the Phosphatidylinositol 3–kinase/Akt pathway contributes to survival of primary epithelial cells infected with the periodontal pathogen Porphyromonas …
- Cutting edge: T cell development requires the combined activities of the p110γ and p110δ catalytic isoforms of Phosphatidylinositol 3–kinase
- Auxin-induced reactive oxygen species production requires the activation of Phosphatidylinositol 3–kinase
- Involvement of the Phosphatidylinositol 3–kinase/rac1 and cdc42 pathways in radial migration of cortical neurons
- Nongenomic androgen activation of Phosphatidylinositol 3‐kinase/Akt signaling pathway in MC3T3‐E1 osteoblasts
- Flavivirus activates Phosphatidylinositol 3–kinase signaling to block caspase-dependent apoptotic cell death at the early stage of virus infection
- Activation of the pro-survival Phosphatidylinositol 3–kinase/AKT pathway by transforming growth factor-β1 in mesenchymal cells is mediated by p38 MAPK …
- Phosphatidylinositol 3–kinase activates ERK in primary sensory neurons and mediates inflammatory heat hyperalgesia through TRPV1 sensitization
- Interleukin-18 is a pro-hypertrophic cytokine that acts through a Phosphatidylinositol 3–kinase-phosphoinositide-dependent kinase-1-Akt-GATA4 signaling …
- The p85α subunit of Phosphatidylinositol 3′-kinase binds to and stimulates the GTPase activity of Rab proteins
- Knockdown of MTP18, a novel Phosphatidylinositol 3–kinase-dependent protein, affects mitochondrial morphology and induces apoptosis
- Cross-Talk between Phosphatidylinositol 3–kinase/AKT and c-Jun NH2-Terminal kinase Mediates Survival of Isolated Human Islets
- Endoplasmic reticulum stress–induced apoptosis is partly mediated by reduced insulin signaling through Phosphatidylinositol 3–kinase/Akt and increased glycogen …
- Bisphenol a accelerates terminal differentiation of 3T3-L1 cells into adipocytes through the Phosphatidylinositol 3–kinase pathway
- Lithium activates the Wnt and Phosphatidylinositol 3–kinase Akt signaling pathways to promote cell survival in the absence of soluble survival factors
- Synergistic augmentation of rapamycin-induced autophagy in malignant glioma cells by Phosphatidylinositol 3–kinase/protein kinase B inhibitors
- Adrenomedullin infusion attenuates myocardial ischemia/reperfusion injury through the Phosphatidylinositol 3–kinase/Akt-dependent pathway
- Activation of Phosphatidylinositol 3–kinase by cellular prion protein and its role in cell survival
- BDNF regulates the translation of a select group of mRNAs by a mammalian target of rapamycin-Phosphatidylinositol 3–kinase-dependent pathway during neuronal …
- Inhibition of Phosphatidylinositol 3′-kinase/AKT signaling promotes apoptosis of primary effusion lymphoma cells
- The Phosphatidylinositol 3–kinase/Akt pathway enhances Smad3-stimulated mesangial cell collagen I expression in response to transforming growth factor-β1
- Phosphatidylinositol 3′-kinase activation leads to multidrug resistance protein-1 expression and subsequent chemoresistance in advanced prostate cancer cells
- Latent membrane protein 2A inhibits transforming growth factor-β1-induced apoptosis through the Phosphatidylinositol 3–kinase/Akt pathway
- Microglia release activators of neuronal proliferation mediated by activation of mitogen‐activated protein kinase, Phosphatidylinositol‐3‐kinase/Akt and delta–Notch …
- Acanthamoeba castellanii Induces Host Cell Death via a Phosphatidylinositol 3–kinase-Dependent Mechanism
- Regulation of muscle protein degradation: coordinated control of apoptotic and ubiquitin-proteasome systems by Phosphatidylinositol 3 kinase
- Both mitogen-activated protein kinase and Phosphatidylinositol 3–kinase signalling are required in epidermal growth factor-induced human trophoblast migration
- … protein regulation of early osteoblast genes in human marrow stromal cells is mediated by extracellular signal-regulated kinase and Phosphatidylinositol 3–kinase …
- Ceramide-1-phosphate promotes cell survival through activation of the Phosphatidylinositol 3–kinase/protein kinase B pathway
- … inhibits vascular endothelial growth factor-induced angiogenesis; inhibition of endothelial cell survival and proliferation by targeting Phosphatidylinositol 3′-kinase …
- Gi-protein-dependent inhibition of IL-12 production is mediated by activation of the Phosphatidylinositol 3–kinase-protein 3 kinase B/Akt pathway and JNK
- … through proteasomal degradation of HER2/neu in HER2/neu-overexpressing breast cancer cells via the Phosphatidylinositol 3–kinase/Akt-dependent pathway
- Emodin inhibits tumor cell migration through suppression of the Phosphatidylinositol 3–kinase-Cdc42/Rac1 pathway
- Inhibition of Phosphatidylinositol 3–kinase sensitizes ovarian cancer cells to carboplatin and allows adjunct chemotherapy treatment
- … Induces Rapid Activation of Akt/Protein kinase B-Mammalian Target of Rapamycin-p70S6K Cascade through Phosphatidylinositol 3–kinase in Human Fibroblasts
- REDD1 integrates hypoxia-mediated survival signaling downstream of Phosphatidylinositol 3–kinase
- Mechanisms of erythropoietin‐mediated cardioprotection during ischemia‐reperfusion injury: role of protein kinase C and Phosphatidylinositol 3‐kinase signaling
- Sequential Activation of Phosphatidylinositol 3–kinase, βPix, Rac1, and Nox1 in Growth Factor-Induced Production of H2O2
- Production of matrix metalloproteinase‐9 by activated human monocytes involves a Phosphatidylinositol‐3 kinase/Akt/IKKα/NF‐κB pathway
- Isoflurane protects against myocardial infarction during early reperfusion by activation of Phosphatidylinositol–3–kinase signal transduction: evidence for anesthetic …
- … progenitors and differentiated osteoblasts by β-catenin-dependent and-independent signaling cascades involving Src/ERK and Phosphatidylinositol 3–kinase …
- Differential membrane localization of ERas and Rheb, two Ras-related proteins involved in the Phosphatidylinositol 3–kinase/mTOR pathway
- Human placental growth hormone increases expression of the p85 regulatory unit of Phosphatidylinositol 3–kinase and triggers severe insulin resistance in skeletal …
- Induction of androgen receptor expression by Phosphatidylinositol 3–kinase/Akt downstream substrate, FOXO3a, and their roles in apoptosis of LNCaP …
- Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and Phosphatidylinositol 3–kinase/Akt signaling
- WAVE3-mediated cell migration and lamellipodia formation are regulated downstream of Phosphatidylinositol 3–kinase
- Role of Phosphatidylinositol 3–kinase in the development of hepatocyte preconditioning
- Overexpression of NBS1 contributes to transformation through the activation of Phosphatidylinositol 3–kinase/Akt
- TGF-β1 represses activation and resultant death of microglia via inhibition of Phosphatidylinositol 3–kinase activity
- Inhibition of Phosphatidylinositol 3–kinase amplifies TEGDMA-induced apoptosis in primary human pulp cells
- Mutant epidermal growth factor receptor displays increased signaling through the Phosphatidylinositol–3 kinase/AKT pathway and promotes radioresistance in cells of …
- Atypical protein kinase C (PKCζ/λ) is a convergent downstream target of the insulin-stimulated Phosphatidylinositol 3–kinase and TC10 signaling pathways
- Lipopolysaccharide-induced c-Jun NH2-terminal kinase activation in human neutrophils: role of Phosphatidylinositol 3–kinase and Syk-mediated pathways
- Modulation of Phosphatidylinositol‐3‐kinase/protein kinase B‐and mitogen‐activated protein kinase‐pathways by tea polyphenols in human prostate cancer cells
- Inhibition of Phosphatidylinositol–3–kinase causes increased sensitivity to radiation through a PKB-dependent mechanism
- Statins prevent oxidized LDL-induced injury of glomerular podocytes by activating the Phosphatidylinositol 3–kinase/AKT-signaling pathway
- Akt2, a novel functional link between p38 mitogen-activated protein kinase and Phosphatidylinositol 3–kinase pathways in myogenesis
- Leptin increases cardiomyocyte hyperplasia via extracellular signal-regulated kinase-and Phosphatidylinositol 3–kinase-dependent signaling pathways
- Regulation of heme oxygenase-1 expression through the Phosphatidylinositol 3–kinase/Akt pathway and the Nrf2 transcription factor in response to the …
- Mammalian target of rapamycin positively regulates collagen type I production via a Phosphatidylinositol 3–kinase-independent pathway
- Alteration of Phosphatidylinositol 3–kinase cascade in the multilobulated nuclear formation of adult T cell leukemia/lymphoma (ATLL)
- Aging is associated with decreased pancreatic acinar cell regeneration and Phosphatidylinositol 3–kinase/Akt activation
- Insulin-like growth factor-1 (IGF-1) inversely regulates atrophy-induced genes via the Phosphatidylinositol 3–kinase/Akt/mammalian target of rapamycin (PI3K …
- PIKE (Phosphatidylinositol 3–kinase enhancer)-A GTPase stimulates Akt activity and mediates cellular invasion
- Se-methylselenocysteine inhibits Phosphatidylinositol 3–kinase activity of mouse mammary epithelial tumor cells in vitro
- CXCL16 signals via Gi, Phosphatidylinositol 3–kinase, Akt, IκB kinase, and nuclear factor-κB and induces cell-cell adhesion and aortic smooth muscle cell …
- Dexamethasone induces apoptosis in proliferative chondrocytes through activation of caspases and suppression of the Akt-Phosphatidylinositol 3′-kinase signaling …
- WNK1 activates SGK1 by a Phosphatidylinositol 3–kinase-dependent and non-catalytic mechanism
- Phosphatidylinositol 3–kinase-Mediated Effects of Glucose on Vacuolar H+-ATPase Assembly, Translocation, and Acidification of Intracellular Compartments in Renal …
- The Phosphatidylinositol–3–kinase inhibitor PX-866 overcomes resistance to the epidermal growth factor receptor inhibitor gefitinib in A-549 human non–small cell …
- … protein Gab1 is an essential component of an indirect mechanism for fibroblast growth factor stimulation of the Phosphatidylinositol 3–kinase/Akt antiapoptotic pathway
- Transforming growth factor-β activation of Phosphatidylinositol 3–kinase is independent of Smad2 and Smad3 and regulates fibroblast responses via p21-activated …
- Isoflurane-induced myocardial preconditioning is dependent on Phosphatidylinositol–3–kinase/Akt signalling
- PTEN, but not SHIP2, suppresses insulin signaling through the Phosphatidylinositol 3–kinase/Akt pathway in 3T3-L1 adipocytes
- Retroinfusion of embryonic endothelial progenitor cells attenuates ischemia-reperfusion injury in pigs: role of Phosphatidylinositol 3–kinase/AKT kinase
- … stress induces insulin resistance by activating the nuclear factor-κB pathway and disrupting normal subcellular distribution of Phosphatidylinositol 3–kinase
- Phosphatidylinositol 3–kinase C2α is essential for ATP-dependent priming of neurosecretory granule exocytosis
- … -macrophage colony-stimulating factor signaling and microglial proliferation by anti-CD45RO: role of Hck tyrosine kinase and Phosphatidylinositol 3–kinase/Akt
- Phosphatidylinositol 3–kinase and mTOR signaling pathways regulate RNA polymerase I transcription in response to IGF-1 and nutrients
- Presenilins mediate Phosphatidylinositol 3–kinase/AKT and ERK activation via select signaling receptors: selectivity of PS2 in platelet-derived growth factor …
- Cross-talk between CD14 and complement receptor 3 promotes phagocytosis of mycobacteria: regulation by Phosphatidylinositol 3–kinase and cytohesin-1
- Carbon monoxide differentially modulates STAT1 and STAT3 and inhibits apoptosis via a Phosphatidylinositol 3–kinase/Akt and p38 kinase-dependent STAT3 …
- Phosphatidylinositol 3‐kinase and Akt effectors mediate insulin‐like growth factor‐I neuroprotection in dorsal root ganglia neurons
- Transformation potential of Ras isoforms correlates with activation of Phosphatidylinositol 3–kinase but not ERK
- Hypoxia-induced activation of p38 mitogen-activated protein kinase and Phosphatidylinositol 3′-kinase signaling pathways contributes to expression of interleukin 8 …
- Participation of prolactin receptors and Phosphatidylinositol 3–kinase and MAP kinase pathways in the increase in pancreatic islet mass and sensitivity to …
- … ligand (TRAIL) induces rheumatoid arthritis synovial fibroblast proliferation through mitogen-activated protein kinases and Phosphatidylinositol 3–kinase/Akt
- A3 adenosine receptor activation inhibits cell proliferation via Phosphatidylinositol 3–kinase/Akt-dependent inhibition of the extracellular signal-regulated …
- … -I regulates proliferation and osteoblastic differentiation of calcifying vascular cells via extracellular signal-regulated protein kinase and Phosphatidylinositol 3–kinase …
- … affecting the cell cycle, growth, maintenance, and drug sensitivity are preferentially regulated by anti-HER2 antibody through Phosphatidylinositol 3–kinase …
- Increased phosphorylation of AKAP by inhibition of Phosphatidylinositol 3–kinase enhances human sperm motility through tail recruitment of protein kinase A
- Vacuolar H+-ATPase binding to microfilaments: regulation in response to Phosphatidylinositol 3–kinase activity and detailed characterization of the actin …
- Inhibition of Phosphatidylinositol 3–kinase modifies boar sperm motion parameters
- Semaphorin 4D/plexin-B1 induces endothelial cell migration through the activation of PYK2, Src, and the Phosphatidylinositol 3–kinase-Akt pathway
- Phosphatidylinositol 3–kinase inhibition down-regulates survivin and facilitates TRAIL-mediated apoptosis in neuroblastomas
- Phosphatidylinositol 3–kinase/Akt regulates angiotensin II–induced inhibition of apoptosis in microvascular endothelial cells by governing survivin expression and …
- Insulin-mediated down-regulation of apolipoprotein A5 gene expression through the Phosphatidylinositol 3–kinase pathway: role of upstream stimulatory factor
- Dual regulation of MMP-2 expression by the type 1 insulin-like growth factor receptor: the Phosphatidylinositol 3–kinase/Akt and Raf/ERK pathways transmit …
- … induced expression of CXC chemokine receptor 4 on non-small cell lung cancer cells is regulated by the Phosphatidylinositol 3–kinase/PTEN/AKT/mammalian …
- Phosphatidylinositol 3–kinase is required for rhinovirus-induced airway epithelial cell interleukin-8 expression
- Zn2+ inhibits mitochondrial movement in neurons by Phosphatidylinositol 3–kinase activation
- … activate the AKT kinase in multiple myeloma cells by up-regulating the insulin-like growth factor receptor/insulin receptor substrate-1/Phosphatidylinositol 3–kinase …
- Activation of Phosphatidylinositol 3–kinase and extracellular signal-regulated kinase is required for glial cell line-derived neurotrophic factor-induced migration and …
- Platelet-derived growth factor stimulates membrane lipid synthesis through activation of Phosphatidylinositol 3–kinase and sterol regulatory element-binding …
- Phosphatidylinositol 3–kinase is involved in α2 (I) collagen gene expression in normal and scleroderma fibroblasts
- IGF-I inhibits apoptosis through the activation of the Phosphatidylinositol 3–kinase/Akt pathway in pituitary cells
- Phosphatidylinositol 3–kinase Offsets cAMP-Mediated Positive Inotropic Effect via Inhibiting Ca2+ Influx in Cardiomyocytes
- Formation of E-cadherin-mediated cell-cell adhesion activates AKT and mitogen activated protein kinase via Phosphatidylinositol 3 kinase and ligand-independent …
- Lipoteichoic acid induces nuclear factor‐κB activation and nitric oxide synthase expression via Phosphatidylinositol 3‐kinase, Akt, and p38 MAPK in RAW 264.7 …
- Glucocorticoid receptor counteracts tumorigenic activity of Akt in skin through interference with the Phosphatidylinositol 3–kinase signaling pathway
- Phosphatidylinositol–3 kinase/Akt and GSK-3 mediated cytoprotective effect of epigallocatechin gallate on oxidative stress-injured neuronal-differentiated N18D3 cells
- Identification of nonsteroidal anti-inflammatory drug-activated gene (NAG-1) as a novel downstream target of Phosphatidylinositol 3–kinase/AKT/GSK-3β …
- … -dependent insulinotropic polypeptide (GIP) stimulation of pancreatic β-cell survival is dependent upon Phosphatidylinositol 3–kinase (PI3K)/protein kinase B …
- Role of the Phosphatidylinositol 3′-kinase–Akt signal pathway in the proliferation of human pancreatic ductal carcinoma cell lines
- Signal regulatory protein α ligation induces macrophage nitric oxide production through JAK/STAT-and Phosphatidylinositol 3–kinase/Rac1/NAPDH oxidase/H2O2 …
- Stable activation of Phosphatidylinositol 3–kinase in the T cell immunological synapse stimulates Akt signaling to FoxO1 nuclear exclusion and cell growth control
- Activation of the Phosphatidylinositol 3–kinase/Akt pathway prevents radiation-induced apoptosis in breast cancer cells
- Hyaluronic acid induces osteopontin via the Phosphatidylinositol 3–kinase/Akt pathway to enhance the motility of human glioma cells
- … regulated by coexpression of human epidermal growth factor receptor 2 and epidermal growth factor receptor via Phosphatidylinositol 3–kinase/AKT signaling pathway …
- CD28 regulates the translation of Bcl-xL via the Phosphatidylinositol 3–kinase/mammalian target of rapamycin pathway
- Impaired activation of Phosphatidylinositol 3–kinase by leptin is a novel mechanism of hepatic leptin resistance in diet-induced obesity
- Regulation of cholinergic gene expression by nerve growth factor depends on the Phosphatidylinositol‐3′‐kinase pathway
- Inhibition of Phosphatidylinositol 3′-kinase induces preferentially killing of PTEN-null T leukemias through AKT pathway
- Nickel Compounds Act through Phosphatidylinositol–3–kinase/Akt-Dependent, p70S6k-Independent Pathway to Induce Hypoxia Inducible Factor Transactivation and …
- Enteric neuroblasts require the Phosphatidylinositol 3–kinase/Akt/Forkhead pathway for GDNF-stimulated survival
- Differential activation of the Phosphatidylinositol 3′-kinase/Akt survival pathway by ionizing radiation in tumor and primary endothelial cells
- Activation of Rac1 by Phosphatidylinositol 3‐kinase in vivo: role in activation of mitogen‐activated protein kinase (MAPK) pathways and retinoic acid‐induced …
- Induction of KLF2 by fluid shear stress requires a novel promoter element activated by a Phosphatidylinositol 3–kinase-dependent chromatin-remodeling …
- Insulin generates free radicals by an NAD (P) H, Phosphatidylinositol 3′-kinase-dependent mechanism in human skin fibroblasts ex vivo
- Insulin-like growth factor-1 regulates endogenous RUNX2 activity in endothelial cells through a Phosphatidylinositol 3–kinase/ERK-dependent and Akt …
- Phosphatidylinositol 3–kinase and frabin mediate Cryptosporidium parvum cellular invasion via activation of Cdc42
- … /human herpesvirus 8 envelope glycoprotein gB induces the integrin-dependent focal adhesion kinase-Src-Phosphatidylinositol 3–kinase-rho GTPase signal pathways …
- Nerve growth factor promotes the survival of sympathetic neurons through the cooperative function of the protein kinase C and Phosphatidylinositol 3–kinase …
- Roles of the Ras-MEK-mitogen-activated protein kinase and Phosphatidylinositol 3–kinase-Akt-mTOR pathways in Jaagsiekte sheep retrovirus-induced transformation …
- Inhibition of p38 mitogen-activated protein kinase and Phosphatidylinositol 3–kinase decreases UVB-induced activator protein-1 and cyclooxygenase-2 in a SKH-1 …
- … induces proliferation, migration, and TGF-β1 expression in mouse glomerular endothelial cells via mitogen-activated protein kinase and Phosphatidylinositol 3–kinase
- p38 and EGF receptor kinase-mediated activation of the Phosphatidylinositol 3–kinase/Akt pathway is required for Zn2+-induced cyclooxygenase-2 expression
- Follicle-stimulating hormone activation of hypoxia-inducible factor-1 by the Phosphatidylinositol 3–kinase/AKT/Ras homolog enriched in brain (Rheb) …
- … line-derived neurotrophic factor increases intracellular calcium concentration: role of calcium/calmodulin in the activation of the Phosphatidylinositol 3–kinase …
- Reciprocal control of Forkhead box O 3a and c-Myc via the Phosphatidylinositol 3–kinase pathway coordinately regulates p27Kip1 levels
- Facilitation of conditioned fear extinction by d-cycloserine is mediated by mitogen-activated protein kinase and Phosphatidylinositol 3–kinase cascades and requires …
- … box transcription factor FOXO3a regulates estrogen receptor alpha expression and is repressed by the Her-2/neu/Phosphatidylinositol 3–kinase/Akt signaling pathway
- Medroxyprogesterone acetate induces cell proliferation through up-regulation of cyclin D1 expression via Phosphatidylinositol 3–kinase/Akt/nuclear factor-κB cascade …
- … is enhanced by N-methyl-D-aspartate receptor activation: essential role of a TNF receptor 2-mediated Phosphatidylinositol 3–kinase-dependent NF-κB …
- LY294002 inhibits LPS-induced NO production through a inhibition of NF-κB activation: independent mechanism of Phosphatidylinositol 3–kinase
- Resistin promotes smooth muscle cell proliferation through activation of extracellular signal–regulated kinase 1/2 and Phosphatidylinositol 3–kinase pathways
- A late, prolonged activation of the Phosphatidylinositol 3–kinase pathway is required for T cell proliferation
- Morphine enhances isoflurane-induced postconditioning against myocardial infarction: the role of Phosphatidylinositol–3–kinase and opioid receptors in rabbits
- Calcium-induced Human Keratinocyte Differentiation Requires src- and fyn-mediated Phosphatidylinositol 3–kinase–dependent Activation of Phospholipase C-γ1
- FGF-2 induced by interleukin-1β through the action of Phosphatidylinositol 3–kinase mediates endothelial mesenchymal transformation in corneal endothelial …
- … of peroxisome proliferator-activated receptor-γ by insulin and C-peptide in kidney proximal tubular cells: dependent on Phosphatidylinositol 3–kinase activity
- IL-18 induces monocyte chemotactic protein-1 production in macrophages through the Phosphatidylinositol 3–kinase/Akt and MEK/ERK1/2 pathways
- Erythropoietin just before reperfusion reduces both lethal arrhythmias and infarct size via the Phosphatidylinositol–3 kinase-dependent pathway in canine hearts
- FSH activates Phosphatidylinositol 3–kinase/protein kinase B signaling pathway in 20-day-old Sertoli cells independently of IGF-I
- Dexamethasone suppresses antigen-induced activation of Phosphatidylinositol 3–kinase and downstream responses in mast cells
- Inhibition of the Phosphatidylinositol 3–kinase/Akt/mammalian target of rapamycin pathway but not the MEK/ERK pathway attenuates laminin-mediated small cell lung …
- Apoptosis and inhibition of the Phosphatidylinositol 3–kinase/Akt signaling pathway in the anti-proliferative actions of dehydroepiandrosterone
- Identification of transcription factor binding sites upstream of human genes regulated by the Phosphatidylinositol 3–kinase and MEK/ERK signaling pathways
- Up-regulation of endothelial nitric oxide synthase via Phosphatidylinositol 3–kinase pathway contributes to ischemic tolerance in the CA1 subfield of gerbil …
- TRAIL-induced apoptosis in human vascular endothelium is regulated by Phosphatidylinositol 3–kinase/Akt through the short form of cellular FLIP and Bcl-2
- Topical treatment with inhibitors of the Phosphatidylinositol 3′-kinase/Akt and Raf/mitogen-activated protein kinase kinase/extracellular signal-regulated kinase …
- Nitric oxide induces hypoxia-inducible factor 1 activation that is dependent on MAPK and Phosphatidylinositol 3–kinase signaling
- A hypoxia-independent hypoxia-inducible factor-1 activation pathway induced by Phosphatidylinositol–3 kinase/Akt in HER2 overexpressing cells
- IL-2 increases human telomerase reverse transcriptase activity transcriptionally and posttranslationally through Phosphatidylinositol 3′-kinase/Akt, heat shock protein …
- FasL (CD95L/APO-1L) resistance of neurons mediated by Phosphatidylinositol 3–kinase-Akt/protein kinase B-dependent expression of lifeguard/neuronal membrane …
- A role for Phosphatidylinositol 3–kinase in TCR-stimulated ERK activation leading to paxillin phosphorylation and CTL degranulation
- Systematic evaluation of anti-apoptotic growth factor signaling in vascular smooth muscle cells: only Phosphatidylinositol 3′-kinase is important
- Neuroprotective effects of the synthetic cannabinoid HU-210 in primary cortical neurons are mediated by Phosphatidylinositol 3–kinase/AKT signaling
- Restoration of SHIP activity in a human leukemia cell line downregulates constitutively activated Phosphatidylinositol 3–kinase/Akt/GSK-3β signaling and leads to an …
- Trophic signals acting via Phosphatidylinositol–3 kinase are required for normal pre-implantation mouse embryo development
- Human mesothelioma cells exhibit tumor cell–specific differences in Phosphatidylinositol 3–kinase/AKT activity that predict the efficacy of Onconase
- … lipoprotein inhibits thrombin-induced endothelial tissue factor expression through inhibition of RhoA and stimulation of Phosphatidylinositol 3–kinase but not Akt …
- Inhibition of Phosphatidylinositol 3–kinase-and ERK MAPK-regulated protein synthesis reveals the pro-apoptotic properties of CD40 ligation in carcinoma cells
- HIV‐1 gp120‐induced TNF‐α production by primary human macrophages is mediated by Phosphatidylinositol‐3 (PI‐3) kinase and mitogen‐activated protein (MAP) …
- … proliferator-activated receptor-γ by rosiglitazone protects human islet cells against human islet amyloid polypeptide toxicity by a Phosphatidylinositol 3′-kinase …
- A linear signal transduction pathway involving Phosphatidylinositol 3–kinase, protein kinase Cϵ, and MAPK in mesangial cells regulates interferon-γ-induced …
- Inhibition of Phosphatidylinositol 3–kinase/Akt and histone deacetylase activity induces apoptosis in non–small cell lung cancer in vitro and in vivo
- Interaction and functional analyses of human VPS34/p150 Phosphatidylinositol 3‐kinase complex with Rab7
- The pro-inflammatory mediator leukotriene D4 induces Phosphatidylinositol 3–kinase and Rac-dependent migration of intestinal epithelial cells
- … -Induced Oocyte Maturation in Atlantic Croaker (Micropogonias undulatus) Is Dependent on Activation of the Phosphatidylinositol 3–kinase/Akt Signal Transduction …
- Inhibition of the Phosphatidylinositol 3′-kinase signaling pathway leads to decreased insulin-stimulated adiponectin secretion from 3T3-L1 adipocytes
- Treating breast cancer through novel inhibitors of the Phosphatidylinositol 3‘-kinase pathway
- Phosphatidylinositol 3‐kinase and Akt participate in the FSH‐induced meiotic maturation of mouse oocytes
- Neurofibromatosis 2 (NF2) tumor suppressor merlin inhibits Phosphatidylinositol 3–kinase through binding to PIKE-L
- Activation of Phosphatidylinositol 3–kinase, Akt, and mammalian target of rapamycin is necessary for hypoxia-induced pulmonary artery adventitial fibroblast …
- The magnitude of Akt/Phosphatidylinositol 3′-kinase proliferating signaling is related to CD45 expression in human myeloma cells
- Response of Non–Small Cell Lung Cancer Cells to the Inhibitors of Phosphatidylinositol 3–kinase/Akt- and MAPK kinase 4/c-Jun NH2-Terminal kinase Pathways …
- RhoA activation mediates Phosphatidylinositol 3–kinase–dependent proliferation of human vascular endothelial cells: an alloimmune mechanism of chronic allograft …
- Insulin-like growth factor 1 inhibits extracellular signal-regulated kinase to promote neuronal survival via the Phosphatidylinositol 3–kinase/protein kinase A/c-Raf …
- … substrate metabolism of mouse cumulus-oocyte complexes: response to follicle-stimulating hormone is mediated by the Phosphatidylinositol 3–kinase pathway and is …
- A Rac1/Phosphatidylinositol 3–kinase/Akt3 anti-apoptotic pathway, triggered by AlsinLF, the product of the ALS2 gene, antagonizes Cu/Zn-superoxide …
- Protein phosphatase-2Cα as a positive regulator of insulin sensitivity through direct activation of Phosphatidylinositol 3–kinase in 3T3-L1 adipocytes
- Suppression of Phosphatidylinositol 3–kinase/Akt signaling pathway is a determinant of the sensitivity to a novel histone deacetylase inhibitor, FK228, in lung …
- Phosphatidylinositol 3–kinase signaling is involved in neurogenesis during Xenopus embryonic development
- Phosphatidylinositol‐3 kinase is distinctively required for µ‐, but not κ‐opioid receptor‐induced activation of c‐Jun N‐terminal kinase
- AMPA protects cultured neurons against glutamate excitotoxicity through a Phosphatidylinositol 3‐kinase‐dependent activation in extracellular signal‐regulated …
- N-WASP and WAVE2 acting downstream of Phosphatidylinositol 3–kinase are required for myogenic cell migration induced by hepatocyte growth factor
- Differential sensitivity of Phosphatidylinositol 3–kinase p110γ to isoforms of G protein βγ dimers
- Epidermal growth factor stimulation of RPE cell survival: contribution of Phosphatidylinositol 3–kinase and mitogen-activated protein kinase pathways
- PWT-458, a novel pegylated-17-hydroxywortmannin, inhibits Phosphatidylinositol 3–kinase signaling and suppresses growth of solid tumors
- Phosphatidylinositol 3–kinase/Akt induced by erythropoietin renders the erythroid differentiation factor GATA-1 competent for TIMP-1 gene transactivation
- Post-ischemic cardioprotection by A2A adenosine receptors: dependent of Phosphatidylinositol 3–kinase pathway
- Calorie restriction increases the ratio of Phosphatidylinositol 3–kinase catalytic to regulatory subunits in rat skeletal muscle
- nitric oxide triggers the Phosphatidylinositol 3–kinase/Akt survival pathway in insulin-producing RINm5F cells by arousing Src to activate insulin receptor substrate-1
- Phosphatidylinositol 3–kinase regulates thymic exit
- … Group A2 Potentiates Genotoxic Stress in Part through the Modulation of Basal and DNA Damage–Dependent Phosphatidylinositol 3–kinase–Related Protein kinase …
- Dynamic reorganization of the astrocyte actin cytoskeleton elicited by cAMP and PACAP: a role for Phosphatidylinositol 3‐kinase inhibition
- Pulmonary surfactant protein A activates a Phosphatidylinositol 3–kinase/calcium signal transduction pathway in human macrophages: participation in the up …
- Novel mechanism of interaction of p85 subunit of Phosphatidylinositol 3–kinase and ErbB3 receptor-derived phosphotyrosyl peptides
- Role for the pleckstrin homology domain-containing protein CKIP-1 in Phosphatidylinositol 3–kinase-regulated muscle differentiation
- VEGF165 and angiopoietin-1 decreased myocardium infarct size through Phosphatidylinositol–3 kinase and Bcl-2 pathways
- Hypothalamic Phosphatidylinositol 3‐kinase‐phosphodiesterase 3B‐cyclic AMP pathway of leptin signalling is impaired following chronic central leptin infusion
- Akt2, Phosphatidylinositol 3–kinase, and PTEN are in lipid rafts of intestinal cells: role in absorption and differentiation
- CD40/CD40 homodimers are required for CD40-induced Phosphatidylinositol 3–kinase-dependent expression of B7. 2 by human B lymphocytes
- A permissive role for Phosphatidylinositol 3–kinase in the Stat5-mediated expression of cyclin D2 by the interleukin-2 receptor
- Epidermal growth factor–induced cyclooxygenase-2 expression is mediated through Phosphatidylinositol–3 kinase, not mitogen-activated protein/extracellular signal …
- The Phosphatidylinositol 3–kinase/protein kinase B signaling pathway is activated by lipoteichoic acid and plays a role in Kupffer cell production of interleukin-6 (IL-6) …
- Differential regulation of Phosphatidylinositol 3–kinase/Akt, mitogen-activated protein kinase, and AMP-activated protein kinase pathways during menadione-induced …
- Mammary epithelial-mesenchymal interaction regulates fibronectin alternative splicing via Phosphatidylinositol 3–kinase
- Costimulation by CD137/4–1BB inhibits T cell apoptosis and induces Bcl‐xL and c‐FLIPshort via Phosphatidylinositol 3‐kinase and AKT/protein kinase B
- A specific antagonist of the p110δ catalytic component of Phosphatidylinositol 3′-kinase, IC486068, enhances radiation-induced tumor vascular destruction
- The role of phospholipase C and Phosphatidylinositol 3–kinase in vascular smooth muscle cell migration and proliferation
- … hydroxy estradiol induces expression of hypoxia-inducible factor 1α and vascular endothelial growth factor A through Phosphatidylinositol 3–kinase/Akt/FRAP pathway …
- … class I antibodies confers resistance to endothelial cells against antibody complement‐mediated lysis by regulating Bad through the Phosphatidylinositol 3‐kinase/Akt …
- Calcium-sensing receptor induces proliferation through p38 mitogen-activated protein kinase and Phosphatidylinositol 3–kinase but not extracellularly regulated …
- SH2-B promotes insulin receptor substrate 1 (IRS1)-and IRS2-mediated activation of the Phosphatidylinositol 3–kinase pathway in response to leptin
- The mammalian target of rapamycin-p70 ribosomal S6 kinase but not Phosphatidylinositol 3–kinase-Akt signaling is responsible for fibroblast growth factor-9 …
- … -induced signaling pathway in endothelial cells resulting in the overexpression of vascular endothelial growth factor involves Ras and Phosphatidylinositol 3–kinase
- Low [Mg2+]e Enhances Arterial Spontaneous Tone via Phosphatidylinositol 3–kinase in DOCA-Salt Hypertension
- Inhibition of either Phosphatidylinositol 3–kinase/Akt or the mitogen/extracellular-regulated kinase, MEK/ERK, signaling pathways suppress growth of breast cancer …
- Phosphatidylinositol 3–kinase (PI-3K)/Akt but not PI-3K/p70 S6 kinase signaling mediates IGF-1-promoted lens epithelial cell survival
- … -δ12, 14-prostaglandin J2 inhibits the inflammatory response in primary rat astrocytes via down-regulating multiple steps in Phosphatidylinositol 3–kinase-akt-NF-κB …
- The bile acid tauroursodeoxycholic acid modulates phosphorylation and translocation of bad via Phosphatidylinositol 3–kinase in glutamate-induced apoptosis of rat …
- Comparison of Phosphatidylinositol–3–kinase signalling within a panel of human colorectal cancer cell lines with mutant or wild-type PIK3CA
- Gαq inhibits cardiac L-type Ca2+ channels through Phosphatidylinositol 3–kinase
- The influence of Phosphatidylinositol 3‐kinase/Akt pathway on the ischemic injury during rat liver graft preservation
- … ‐stimulating factor‐, or IL‐3‐dependent survival of macrophages, but not proliferation, requires the expression of p21Waf1 through the Phosphatidylinositol 3‐kinase …
- RhoA controls myoblast survival by inducing the Phosphatidylinositol 3‐kinase‐Akt signaling pathway
- Functional integrity of nuclear factor κB, Phosphatidylinositol 3′-kinase, and mitogen-activated protein kinase signaling allows tumor necrosis factor α-evoked Bcl-2 …
- Phosphatidylinositol 3–kinase, phosphoinositide-specific phospholipase-Cγ and protein kinase-C signal myelin phagocytosis mediated by complement receptor-3 …
- M-CSF stimulated differentiation requires persistent MEK activity and MAPK phosphorylation independent of Grb2–Sos association and Phosphatidylinositol 3–kinase …
- … Aminoimidazole-4-carboxamide riboside suppresses lipopolysaccharide-induced TNF-α production through inhibition of Phosphatidylinositol 3–kinase/Akt activation in …
- Activation of nuclear factor kappa B by diesel exhaust particles in mouse epidermal cells through Phosphatidylinositol 3–kinase/Akt signaling pathway
- Phosphatidylinositol 3–kinase is a determinant of responsiveness to B cell antigen receptor-mediated Epstein-Barr virus activation
- Phosphatidylinositol 3–kinase inhibitors reveal a unique mechanism of enhancing insulin secretion in 832/13 rat insulinoma cells
- The integrin β1 subunit transmembrane domain regulates Phosphatidylinositol 3–kinase-dependent tyrosine phosphorylation of Crk-associated substrate
- Integrin activation by bacterial fimbriae through a pathway involving CD14, Toll‐like receptor 2, and Phosphatidylinositol‐3‐kinase
- cAMP-stimulated Na+ transport in H441 distal lung epithelial cells: role of PKA, Phosphatidylinositol 3–kinase, and sgk1
- Roles of Phosphatidylinositol 3′-kinase and mammalian target of rapamycin/p70 ribosomal protein S6 kinase in K-Ras-mediated transformation of intestinal epithelial …
- … regulation of human mucin MUC4 by bile acids in oesophageal cancer cells is promoter-dependent and involves activation of the Phosphatidylinositol 3–kinase …
- … cells via MyD88, interleukin-1 receptor-associated kinase, tumor necrosis factor receptor-associated factor 6, c-Src, Phosphatidylinositol 3–kinase, Akt, c-Jun …
- … Pathway Leads to Phosphorylation of Insulin Receptor Substrate-1 on Ser307 and Ser612 and Impairs the Phosphatidylinositol 3–kinase/Akt/Mammalian Target of …
- Phosphatidylinositol 3–kinase inhibitors are a triple threat to ovarian cancer
- Diosgenin induces hypoxia-inducible factor-1 activation and angiogenesis through estrogen receptor-related Phosphatidylinositol 3–kinase/Akt and p38 mitogen …
- Role of Phosphatidylinositol 3–kinase-γ in mediating lung neutrophil sequestration and vascular injury induced by E. coli sepsis
- Aquaporin-2 is retrieved to the apical storage compartment via early endosomes and Phosphatidylinositol 3–kinase-dependent pathway
- Regulation of granulocyte apoptosis by Phosphatidylinositol 3–kinase
- … in human breast cancer cells does not rely on direct induction of mitogen-activated protein kinase/extracellularly regulated kinase or Phosphatidylinositol 3–kinase
- Phosphatidylinositol 3–kinase-dependent signaling modulates taurochenodeoxycholic acid-induced liver injury and cholestasis in perfused rat livers
- Control of cell size through phosphorylation of upstream binding factor 1 by nuclear Phosphatidylinositol 3–kinase
- Activation of Phosphatidylinositol 3‐kinase and c‐Jun‐N‐terminal kinase cascades enhances NF‐κB‐dependent gene transcription in BCG‐stimulated macrophages …
- Mouse embryonic stem cells and preimplantation embryos require signaling through the Phosphatidylinositol 3‐kinase pathway to suppress apoptosis
- Opposing roles of endothelial and smooth muscle Phosphatidylinositol 3–kinase in vasoconstriction: effects of rho-kinase and hypertension
- … -independent activation of GABAergic neurotransmission and receptor-dependent nontranscriptional activation of Phosphatidylinositol 3–kinase/protein kinase Akt …
- Muscarinic M2 receptor stimulation of Cav1. 2b requires Phosphatidylinositol 3–kinase, protein kinase C, and c-Src
- Vav-dependent and vav-independent Phosphatidylinositol 3–kinase activation in murine B cells determined by the nature of the stimulus
- … of the heavy chain of tetanus toxin rescues cerebellar granule neurones from apoptotic death: involvement of Phosphatidylinositol 3‐kinase and mitogen‐activated …
- Phosphatidylinositol 3–kinase/Akt pathway mediates heme oxygenase-1 regulation by lipopolysaccharide.
- Possible involvement of Phosphatidylinositol 3–kinase/Akt pathway in insulin-like growth factor-I-induced alkaline phosphatase activity in osteoblasts
- Deregulation of the Phosphatidylinositol–3 kinase signaling cascade is associated with neurodegeneration in Npc1−/− mouse brain
- Hydrogen peroxide and epidermal growth factor activate Phosphatidylinositol 3–kinase and increase sodium transport in A6 cell monolayers
- Involvement of Phosphatidylinositol 3–kinase and insulin-like growth factor-I in YXLST-mediated neuroprotection
- Survivin contributes to the anti-apoptotic activities of transforming growth factor alpha in mouse blastocysts through Phosphatidylinositol 3‘-kinase pathway
- … inhibits β-amyloid peptide (1-42)-mediated hippocampal neuronal apoptosis through activation of mitogen-activated protein kinase and Phosphatidylinositol 3–kinase …
- Phosphatidylinositol 3‐kinase inhibition enhances human sperm motility and sperm–zona pellucida binding
- Modulation of Phosphatidylinositol 3–kinase signaling reduces intimal hyperplasia in aortocoronary saphenous vein grafts
- α1A-Adrenoceptors Activate Glucose Uptake in L6 Muscle Cells through a Phospholipase C-, Phosphatidylinositol–3 kinase-, and Atypical Protein kinase C …
- Differential effects of P2Y1 and P2Y12 nucleotide receptors on ERK1/ERK2 and Phosphatidylinositol 3‐kinase signalling and cell proliferation in serum‐deprived …
- … via modulation of involucrin and transglutaminase expression through the integrin α3β1 and the Phosphatidylinositol 3–kinase/Akt signaling pathway
- Phosphatidylinositol 3–kinase modulates vascular smooth muscle contraction by calcium and myosin light chain phosphorylation-independent and-dependent …
- … -1 and HNF-4 and the coactivator p300 are involved in insulin-regulated glucokinase gene expression via the Phosphatidylinositol 3–kinase/protein kinase B …
- Mammalian target of rapamycin and 3–Phosphatidylinositol 3–kinase pathway inhibition enhances growth inhibition of transforming growth factor-β1 in prostate cancer …
- Fibroblast growth factor-2 induces osteoblast survival through a Phosphatidylinositol 3–kinase-dependent,-β-catenin-independent signaling pathway
- Activation of MMP-2 in response to vascular injury is mediated by Phosphatidylinositol 3–kinase-dependent expression of MT1-MMP
- Adhesion-independent α6β4 integrin clustering is mediated by Phosphatidylinositol 3–kinase
- … -induced integrin affinity maturation promotes recruitment of αVβ3 integrin to focal adhesions in endothelial cells: Evidence for a role of Phosphatidylinositol 3–kinase …
- NGF-induced Phosphatidylinositol 3–kinase signaling pathway prevents thapsigargin-triggered ER stress-mediated apoptosis in PC12 cells
- Optimal windows of statin use for immediate infarct limitation: 5′-nucleotidase as another downstream molecule of Phosphatidylinositol 3–kinase
- Complementation of human papillomavirus type 16 E6 and E7 by Jagged1-specific Notch1-Phosphatidylinositol 3–kinase signaling involves pleiotropic oncogenic …
- Phosphatidylinositol 3–kinase activator reduces motor neuronal cell death induced by G93A or A4V mutant SOD1 gene
- Transient Phosphatidylinositol 3–kinase inhibition protects immature primary cortical neurons from oxidative toxicity via suppression of extracellular signal …
- Exogenous tissue inhibitor of metalloproteinase‐1 promotes endothelial cell survival through activation of the Phosphatidylinositol 3‐kinase/Akt pathway
- Phosphatidylinositol 3–kinase activation is required for sulfonylurea stimulation of glucose transport in rat skeletal muscle
- Enhancement of osteopontin expression in HepG2 cells by epidermal growth factor via Phosphatidylinositol 3–kinase signaling pathway
- Cloning of Brassica napus phospholipase C2 (BnPLC2), Phosphatidylinositol 3–kinase (BnVPS34) and Phosphatidylinositol synthase1 (BnPtdIns S1)—comparative …
- Biochemical and biological responses induced by coupling of Gab1 to Phosphatidylinositol 3–kinase in RET-expressing cells
- … receptor β/δ (PPARβ/δ) increases the expression of prostaglandin E2 receptor subtype EP4: the roles of Phosphatidylinositol 3–kinase and CCAAT/enhancer …
- Phosphatidylinositol 3–kinase p85α subunit-dependent interaction with BCR/ABL-related fusion tyrosine kinases: molecular mechanisms and biological …
- α-Thrombin-mediated Phosphatidylinositol 3–kinase activation through release of Gβγ dimers from Gαq and Gαi2
- Angiotensin II Regulation of the Na+ Pump Involves the Phosphatidylinositol–3 kinase and p42/44 Mitogen-Activated Protein kinase Signaling Pathways in Vascular …
- Resensitization of P2Y Receptors by Growth Factor–Mediated Activation of the Phosphatidylinositol–3 kinase in Retinal Glial Cells
- Upregulated function of Phosphatidylinositol‐3‐kinase in genetically hypertensive rats: a moderator of arterial hypercontractility
- Adenosine A2A receptor facilitates calcium-dependent protein secretion through the activation of protein kinase A and Phosphatidylinositol–3 kinase in PC12 cells
- … , a diterpenoid triepoxide, induces antitumor proliferation via activation of c-Jun NH2-terminal kinase 1 by decreasing Phosphatidylinositol 3–kinase activity in human …
- Leptin decreases renal medullary Na (+), K (+)-ATPase activity through Phosphatidylinositol 3–kinase dependent mechanism.
- Differential involvement of Phosphatidylinositol 3–kinase and p42/p44 mitogen activated protein kinase pathways in brain-derived neurotrophic factor-induced trophic …
- … epidermal growth factor‐like growth factor stimulates cell proliferation in cerebral cortical cultures through Phosphatidylinositol 3′‐kinase and mitogen‐activated …
- Two distinct regulatory mechanisms of neurotransmitter release by Phosphatidylinositol 3‐kinase
- AND-34 Activates Phosphatidylinositol 3–kinase and Induces Anti-Estrogen Resistance in a SH2 and GDP Exchange Factor–Like Domain-Dependent Manner
- Calcium oscillation and Phosphatidylinositol 3–kinase positively regulate integrin αIIbβ3-mediated outside-in signaling
- Overexpression of the N-terminal end of the p55γ regulatory subunit of Phosphatidylinositol 3–kinase blocks cell cycle progression in gastric carcinoma cells
- Inhibition of Phosphatidylinositol–3–kinase synergizes with gemcitabine in low-passage tumor cell lines correlating with Bax translocation to the mitochondria
- … neurones by brain‐derived neurotrophic factor and Raf‐1 protein kinase: role of extracellular signal‐regulated protein kinase and Phosphatidylinositol 3‐kinase
- Phosphatidylinositol–3–kinase activation mediates proline-rich tyrosine kinase 2 phosphorylation and recruitment to β1-integrins in human CD34+ cells
- Angiopoietin-1 attenuates H2O2-induced SEK1/JNK phosphorylation through the Phosphatidylinositol 3–kinase/Akt pathway in vascular endothelial cells
- RNA interference, A potential strategy for isoform-specific Phosphatidylinositol 3–kinase targeted therapy in ovarian cancer
- Expression of insulin receptor substrates 1-3, glucose transporters GLUT-1-4, signal regulatory protein 1α, Phosphatidylinositol 3–kinase and protein kinase B at the …
- Phosphatidylinositol 3–kinase regulates Ca2+ signaling in pancreatic acinar cells through inhibition of sarco(endo)plasmic reticulum Ca2+-ATPase
- In vitro metabolism of the Phosphatidylinositol 3–kinase inhibitor, wortmannin, by carbonyl reductase
- Interleukin-2-induced survival of natural killer (NK) cells involving Phosphatidylinositol–3 kinase-dependent reduction of ceramide through acid sphingomyelinase …
- T cell leukemia-1 modulates TCR signal strength and IFN-γ levels through Phosphatidylinositol 3–kinase and protein kinase C pathway activation
- Adenosine A3 receptor-mediated regulation of p38 and extracellular-regulated kinase ERK1/2 via Phosphatidylinositol–3′-kinase
- Negative Feedback Regulation of Phosphatidylinositol 3‐kinase/Akt Pathway by Over‐Expressed Cyclooxygenase‐2 in Human Epidermal Cancer Cells
- Group IB secretory phospholipase A2 promotes matrix metalloproteinase-2-mediated cell migration via the Phosphatidylinositol 3–kinase and Akt pathway
- Phosphatidylinositol 3–kinase/Akt-dependent and-independent protection against apoptosis in normal human melanocytes
- Generation and functional in vivo characterization of a lipid kinase defective Phosphatidylinositol 3–kinase Vps34p of Candida albicans
- Phosphatidylinositol‐3 kinase inhibitors reproduce the selective antiproliferative effects of imatinib on chronic myeloid leukaemia progenitor cells
- … adhesion is controlled by src-kinases, whereas PF-4–mediated exocytosis requires the additional activation of p38 MAP kinase and Phosphatidylinositol 3–kinase
- Prolactin and heregulin override DNA damage-induced growth arrest and promote Phosphatidylinositol–3 kinase-dependent proliferation in breast cancer cells
- Hemangiopoietin inhibits apoptosis of MO7e leukemia cells through Phosphatidylinositol 3–kinase–AKT pathway
