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REVERSAL OF OBESITY
September 23, 2022
ORGANOTINS
September 23, 2022
  1. Phosphatidylinositol 3‐kinase
  2. Activation of Phosphatidylinositol 3–kinase by insulin.
  3. The activation of Phosphatidylinositol 3–kinase by Ras
  4. Association of focal adhesion kinase with its potential substrate Phosphatidylinositol 3–kinase.
  5. Phosphatidylinositol 3–kinase related kinases
  6. Phosphatidylinositol 3–kinase Encoded by Yeast VPS34 Gene Essential for Protein Sorting
  7. Phosphatidylinositol 3–kinase: structure and expression of the 110 kd catalytic subunit
  8. Wortmannin is a potent Phosphatidylinositol 3–kinase inhibitor: the role of Phosphatidylinositol 3, 4, 5-trisphosphate in neutrophil responses
  9. Requirement for Phosphatidylinositol–3 kinase in the prevention of apoptosis by nerve growth factor
  10. Ras-dependent induction of cellular responses by constitutively active Phosphatidylinositol–3 kinase
  11. Activation of Phosphatidylinositol–3′ kinase by Src-family kinase SH3 binding to the p85 subunit
  12. Phosphatidylinositol 3′‐kinase is activated by association with IRS‐1 during insulin stimulation.
  13. A human Phosphatidylinositol 3‐kinase complex related to the yeast Vps34p‐Vps15p protein sorting system.
  14. Wortmannin, a potent and selective inhibitor of Phosphatidylinositol–3–kinase
  15. A specific inhibitor of Phosphatidylinositol 3–kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).
  16. The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated Phosphatidylinositol 3–kinase
  17. Membrane localization of Phosphatidylinositol 3–kinase is sufficient to activate multiple signal-transducing kinase pathways
  18. The Phosphatidylinositol 3–kinase alpha is required for DNA synthesis induced by some, but not all, growth factors.
  19. Cloning of a novel, ubiquitously expressed human Phosphatidylinositol 3–kinase and identification of its binding site on p85
  20. Inhibition of Phosphatidylinositol 3–kinase activity by association with 14-3–3 proteins in T cells.
  21. Phosphatidylinositol 3‘kinase: one of the effectors of Ras
  22. Association of p21ras with Phosphatidylinositol 3–kinase.
  23. Interaction of Phosphatidylinositol 3–kinase-associated p85 with epidermal growth factor and platelet-derived growth factor receptors
  24. ErbB3 is involved in activation of Phosphatidylinositol 3–kinase by epidermal growth factor
  25. Phosphatidylinositol–3 kinase activity is regulated by BCR/ABL and is required for the growth of Philadelphia chromosome-positive cells
  26. Activation of the Eck receptor protein tyrosine kinase stimulates Phosphatidylinositol 3–kinase activity.
  27. Phosphatidylinositol 3–kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation
  28. The inhibition of Phosphatidylinositol 3–kinase by quercetin and analogs
  29. Phosphatidylinositol 3–kinase inhibitors block differentiation of skeletal muscle cells
  30. Studies on the mechanism of Phosphatidylinositol 3–kinase inhibition by wortmannin and related analogs
  31. CD19 of B cells as a surrogate kinase insert region to bind Phosphatidylinositol 3–kinase
  32. DNA-dependent protein kinase catalytic subunit: a relative of Phosphatidylinositol 3–kinase and the ataxia telangiectasia gene product
  33. Involvement of Phosphatidylinositol 3–kinase in Fc gamma receptor signaling.
  34. The interaction of small domains between the subunits of Phosphatidylinositol 3–kinase determines enzyme activity
  35. Interkinase domain of kit contains the binding site for Phosphatidylinositol 3‘kinase.
  36. Mechanism of down-regulation of c-kit receptor. Roles of receptor tyrosine kinase, Phosphatidylinositol 3‘-kinase, and protein kinase C.
  37. Mouse p170 is a novel Phosphatidylinositol 3–kinase containing a C2 domain
  38. Inhibition of the Phosphatidylinositol 3–kinase/p70S6-kinase pathway induces B16 melanoma cell differentiation
  39. Epidermal growth factor-dependent association of Phosphatidylinositol 3–kinase with the erbB3 gene product.
  40. The structure and function of p55PIK reveal a new regulatory subunit for Phosphatidylinositol 3–kinase
  41. Phosphatidylinositol 3–kinase and its novel product, Phosphatidylinositol 3-phosphate, are present in Saccharomyces cerevisiae
  42. Phosphatidylinositol 3–kinase Is an Early Intermediate in the Gβγ-mediated Mitogen-activated Protein kinase Signaling Pathway (∗)
  43. Phosphatidylinositol (3, 4, 5) P3 interacts with SH2 domains and modulates PI 3–kinase association with tyrosine-phosphorylated proteins
  44. Rac GTPase interacts specifically with Phosphatidylinositol 3–kinase
  45. The Phosphatidylinositol 3–kinase serine kinase phosphorylates IRS-1. Stimulation by insulin and inhibition by Wortmannin.
  46. Insulin stimulation of Phosphatidylinositol 3–kinase activity and association with insulin receptor substrate 1 in liver and muscle of the intact rat.
  47. A novel recognition motif for Phosphatidylinositol 3–kinase binding mediates its association with the hepatocyte growth factor/scatter factor receptor
  48. In vitro and in vivo antitumor activity of the Phosphatidylinositol–3–kinase inhibitor, wortmannin.
  49. Essential role of Phosphatidylinositol 3–kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. Studies with a selective inhibitor …
  50. Activation of Phosphatidylinositol 3–kinase in cells expressing abl oncogene variants
  51. Regulation of Phosphatidylinositol 3–kinase activity in liver and muscle of animal models of insulin-resistant and insulin-deficient diabetes mellitus.
  52. EGF or PDGF receptors activate atypical PKClambda through Phosphatidylinositol 3‐kinase.
  53. T-cell antigen CD28 interacts with the lipid kinase Phosphatidylinositol 3–kinase by a cytoplasmic Tyr (P)-Met-Xaa-Met motif.
  54. Investigation of neutrophil signal transduction using a specific inhibitor of Phosphatidylinositol 3–kinase.
  55. Evidence for Phosphatidylinositol 3–kinase as a regulator of endocytosis via activation of Rab5.
  56. The tyrosine-phosphorylated hepatocyte growth factor/scatter factor receptor associates with Phosphatidylinositol 3–kinase.
  57. Insulin activates a p21-activated kinase in muscle cells via Phosphatidylinositol 3–kinase
  58. Phosphatidylinositol 3–kinase signals activate a selective subset of Rac/Rho-dependent effector pathways
  59. Inhibition of histamine secretion by wortmannin through the blockade of Phosphatidylinositol 3–kinase in RBL-2H3 cells.
  60. Phosphatidylinositol 3–kinase binds to α-actinin through the p85 subunit
  61. Phospholipase C-γ1 and Phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor’s mitogenic signal
  62. Identification of c‐erbB‐3 binding sites for Phosphatidylinositol 3′‐kinase and SHC using an EGF receptor/c‐erbB‐3 chimera.
  63. Akt Is a Direct Target of the Phosphatidylinositol 3–kinase: ACTIVATION BY GROWTH FACTORS, v-src and v-Ha-ras, IN Sf9 AND MAMMALIAN CELLS
  64. SH2 domains of the p85 alpha subunit of Phosphatidylinositol 3–kinase regulate binding to growth factor receptors
  65. Role for Phosphatidylinositol 3–kinase in the sorting and transport of newly synthesized lysosomal enzymes in mammalian cells.
  66. Oligodendrocytes and their precursors require Phosphatidylinositol 3–kinase signaling for survival
  67. Inhibition of the translocation of GLUT1 and GLUT4 in 3T3-L1 cells by the Phosphatidylinositol 3–kinase inhibitor, wortmannin
  68. Identification of Trk binding sites for SHC and Phosphatidylinositol 3‘-kinase and formation of a multimeric signaling complex.
  69. Phosphatidylinositol 3–kinase activity is required for early endosome fusion
  70. CTLA-4 binding to the lipid kinase Phosphatidylinositol 3–kinase in T cells.
  71. Wortmannin, a specific inhibitor of Phosphatidylinositol–3 kinase, blocks osteoclastic bone resorption
  72. Activation of RAC-protein kinase by heat shock and hyperosmolarity stress through a pathway independent of Phosphatidylinositol 3–kinase.
  73. Dominant missense mutations in a novel yeast protein related to mammalian Phosphatidylinositol 3–kinase and VPS34 abrogate rapamycin cytotoxicity
  74. Membrane ruffling and chemotaxis transduced by the PDGF beta-receptor require the binding site for Phosphatidylinositol 3‘kinase.
  75. Molecular cloning, cDNA sequence, and chromosomal localization of the human Phosphatidylinositol 3–kinase p110α (PIK3CA) gene
  76. Phosphatidylinositol 3–kinase Activity Is Required at a Postendocytic Step in Platelet-derived Growth Factor Receptor Trafficking∗
  77. Requirement of Phosphatidylinositol–3 kinase modification for its association with p60src
  78. Neurite outgrowth of PC12 cells is suppressed by wortmannin, a specific inhibitor of Phosphatidylinositol 3–kinase.
  79. Phosphorylation of the PDGF receptor beta subunit creates a tight binding site for Phosphatidylinositol 3 kinase.
  80. CD28 of T lymphocytes associates with Phosphatidylinositol 3–kinase
  81. The v-Src SH3 domain binds Phosphatidylinositol 3‘-kinase
  82. Signal transduction via CD40 involves activation of lyn kinase and Phosphatidylinositol–3–kinase, and phosphorylation of phospholipase C gamma 2.
  83. Blockage of chemotactic peptide-induced stimulation of neutrophils by wortmannin as a result of selective inhibition of Phosphatidylinositol 3–kinase.
  84. Hepatocyte growth factor-induced scatter of Madin-Darby canine kidney cells requires Phosphatidylinositol 3–kinase
  85. Role of Phosphatidylinositol–3–kinase in insulin receptor signaling: studies with inhibitor, LY294002
  86. Identification of two SH3-binding motifs in the regulatory subunit of Phosphatidylinositol 3–kinase.
  87. Acute regulation by insulin of Phosphatidylinositol–3–kinase, Rad, Glut 4, and lipoprotein lipase mRNA levels in human muscle.
  88. Phosphatidylinositol 3‐kinase regulation of fluid phase endocytosis
  89. Phosphatidylinositol 3–kinase activation in normal human B lymphocytes.
  90. Wortmannin, a specific Phosphatidylinositol 3–kinase inhibitor, inhibits adipocytic differentiation of 3T3-L1 cells
  91. A Phosphatidylinositol–3 kinase binds to platelet-derived growth factor receptors through a specific receptor sequence containing phosphotyrosine
  92. Solution structure and ligand-binding site of the SH3 domain of the p85α subunit of Phosphatidylinositol 3–kinase
  93. Polyphosphoinositides produced by Phosphatidylinositol 3–kinase are poor substrates for phospholipases C from rat liver and bovine brain
  94. Stimulation of CD28 triggers an association between CD28 and Phosphatidylinositol 3–kinase in Jurkat T cells.
  95. A comparison of demethoxyviridin and wortmannin as inhibitors of Phosphatidylinositol 3‐kinase
  96. Activated Phosphatidylinositol 3–kinase is sufficient to mediate actin rearrangement and GLUT4 translocation in 3T3-L1 adipocytes
  97. Interactions of Cbl with Grb2 and Phosphatidylinositol 3‘-kinase in activated Jurkat cells
  98. Membrane Ig cross-linking regulates Phosphatidylinositol 3–kinase in B lymphocytes.
  99. Growth factor-dependent survival of rodent fibroblasts requires Phosphatidylinositol 3–kinase but is independent of pp70S6K activity.
  100. Selective CD28pYMNM mutations implicate Phosphatidylinositol 3–kinase in CD86-CD28-mediated costimulation
  101. Direct activation of the Phosphatidylinositol 3‘-kinase by the insulin receptor.
  102. Nerve growth factor promotes the activation of Phosphatidylinositol 3–kinase and its association with the trk tyrosine kinase.
  103. … factor activates protein kinase C epsilon through redundant and independent signaling pathways involving phospholipase C gamma or Phosphatidylinositol 3–kinase.
  104. Phosphorylation of middle T by pp60c-src: a switch for binding of Phosphatidylinositol 3–kinase and optimal tumorigenesis
  105. Activation of Src-like protein-tyrosine kinase Lyn and its association with Phosphatidylinositol 3–kinase upon B-cell antigen receptor-mediated signaling.
  106. Direct Association of Grb2 with the p85 Subunit of Phosphatidylinositol 3–kinase (∗)
  107. Overexpression of a constitutively active form of Phosphatidylinositol 3–kinase is sufficient to promote Glut 4 translocation in adipocytes
  108. Antagonists of Phosphatidylinositol 3–kinase block activation of several novel protein kinases in neutrophils
  109. Interleukin-2 triggers a novel Phosphatidylinositol 3–kinase-dependent MEK activation pathway
  110. GTPase-activating protein and Phosphatidylinositol 3–kinase bind to distinct regions of the platelet-derived growth factor receptor beta subunit
  111. Defect in skeletal muscle Phosphatidylinositol–3–kinase in obese insulin-resistant mice.
  112. Protein kinase C δ specifically associates with Phosphatidylinositol 3–kinase following cytokine stimulation
  113. p56Lck and p59Fyn regulate CD28 binding to Phosphatidylinositol 3–kinase, growth factor receptor-bound protein GRB-2, and T cell-specific protein-tyrosine kinase …
  114. Phosphatidylinositol 3–kinase activation is mediated by high-affinity interactions between distinct domains within the p110 and p85 subunits
  115. AtVPS34, a Phosphatidylinositol 3–kinase of Arabidopsis thaliana, is an essential protein with homology to a calcium-dependent lipid binding domain.
  116. Efficient coupling with Phosphatidylinositol 3–kinase, but not phospholipase C gamma or GTPase-activating protein, distinguishes ErbB-3 signaling from that of other …
  117. Requirement for Phosphatidylinositol 3–kinase in epidermal growth factor-induced AP-1 transactivation and transformation in JB6 P+ cells
  118. Modulation of insulin receptor, insulin receptor substrate-1, and Phosphatidylinositol 3–kinase in liver and muscle of dexamethasone-treated rats.
  119. Adrenergic Receptors Activate Phosphatidylinositol 3–kinase in Human Vascular Smooth Muscle Cells: ROLE IN MITOGENESIS (∗)
  120. Phosphatidylinositol–3 kinase activation induced upon Fc gamma RIIIA-ligand interaction.
  121. Phosphatidylinositol 3–kinase is activated by nerve growth factor and epidermal growth factor in PC12 cells.
  122. Insulin-stimulated Phosphatidylinositol 3–kinase. Association with a 185-kDa tyrosine-phosphorylated protein (IRS-1) and localization in a low density …
  123. Regulation of Phosphatidylinositol 3′-kinase by tyrosyl phosphoproteins: full activation requires occupancy of Both SH2 domains in the 85-kDa regulatory …
  124. Wortmannin causes mistargeting of procathepsin D. evidence for the involvement of a Phosphatidylinositol 3–kinase in vesicular transport to lysosomes.
  125. Phosphatidylinositol 3–kinase associates, via its Src homology 2 domains, with the activated erythropoietin receptor
  126. Phosphatidylinositol 3–kinase mediates the inhibitory effect of epidermal growth factor on calcium-dependent chloride secretion
  127. The Phosphatidylinositol 3–kinase Inhibitor Wortmannin Sensitizes Murine Fibroblasts and Human Tumor Cells to Radiation and Blocks Induction of p53 following …
  128. 1-Phosphatidylinositol 3–kinase activity is required for insulin-stimulated glucose transport but not for RAS activation in CHO cells.
  129. The inability of Phosphatidylinositol 3–kinase activation to stimulate GLUT4 translocation indicates additional signaling pathways are required for insulin-stimulated …
  130. Insulin stimulation of Phosphatidylinositol 3–kinase activity maps to insulin receptor regions required for endogenous substrate phosphorylation.
  131. Overexpression of catalytic subunit p110α of Phosphatidylinositol 3–kinase increases glucose transport activity with translocation of glucose transporters in …
  132. Platelet-derived growth factor-induced Phosphatidylinositol 3–kinase activation mediates actin rearrangements in fibroblasts
  133. Regulated coupling of the Neu receptor to Phosphatidylinositol 3‘-kinase and its release by oncogenic activation.
  134. Requirement for Phosphatidylinositol 3‘-kinase to protect hemopoietic progenitors against apoptosis depends upon the extracellular survival factor.
  135. The proto-oncogene product p120CBL and the adaptor proteins CRKL and c-CRK link c-ABL, p190BCR/ABL and p210BCR/ABL to the Phosphatidylinositol–3‘kinase …
  136. Internalization of activated platelet-derived growth factor receptor-Phosphatidylinositol–3‘kinase complexes: potential interactions with the microtubule cytoskeleton
  137. A regulatory role for cAMP in Phosphatidylinositol 3–kinase/p70 ribosomal S6 kinase-mediated DNA synthesis in platelet-derived-growth-factor-stimulated bovine …
  138. Phosphatidylinositol 3–kinase signals activation of p70 S6 kinase in situ through site-specific p70 phosphorylation.
  139. Bacterial lipopolysaccharide induces the association and coordinate activation of p53/56lyn and Phosphatidylinositol 3–kinase in human monocytes.
  140. Two types of Phosphatidylinositol 3–kinase from bovine thymus. Monomer and heterodimer form
  141. Multiple roles of Phosphatidylinositol 3–kinase in regulation of glucose transport, amino acid transport, and glucose transporters in L6 skeletal muscle cells
  142. Stimulation of Phosphatidylinositol 3‘-kinase association with foca adhesion kinase by platelet-derived growth factor.
  143. Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation, and Phosphatidylinositol 3–kinase activity are decreased in intact skeletal muscle strips …
  144. Association of Phosphatidylinositol 3–kinase with SHC in chronic myelogeneous leukemia cells.
  145. Both Phosphatidylinositol 3–kinase and Phosphatidylinositol 4-kinase products are increased by antigen receptor signaling in B cells.
  146. Profilin and gelsolin stimulate Phosphatidylinositol 3–kinase activity
  147. Phosphorylation of tyrosine 397 in focal adhesion kinase is required for binding Phosphatidylinositol 3–kinase
  148. … Inhibit Stimulated Phospholipase A2 Activity in Swiss 3T3 Cells: WORTMANNIN IS NOT A SPECIFIC INHIBITOR OF Phosphatidylinositol 3–kinase (∗ …
  149. Insulin and insulinomimetic agents induce activation of Phosphatidylinositol 3‘-kinase upon its association with pp185 (IRS-1) in intact rat livers.
  150. Multiple cytokines activate Phosphatidylinositol 3–kinase in hemopoietic cells. Association of the enzyme with various tyrosine-phosphorylated proteins.
  151. IRS-1 activates Phosphatidylinositol 3‘-kinase by associating with src homology 2 domains of p85.
  152. Requirement of Phosphatidylinositol–3 kinase for epithelial cell migration activated by human macrophage stimulating protein.
  153. Effect of aging on insulin receptor, insulin receptor substrate-1, and Phosphatidylinositol 3–kinase in liver and muscle of rats
  154. Biased combinatorial libraries: novel ligands for the SH3 domain of Phosphatidylinositol 3–kinase
  155. IRS-1 is a common element in insulin and insulin-like growth factor-I signaling to the Phosphatidylinositol 3‘-kinase
  156. Phosphatidylinositol 3–kinase Recruitment by p185erbB-2 and erbB-3 Is Potently Induced by neu Differentiation Factor/Heregulin during Mitogenesis and Is …
  157. Genetic analysis of a Phosphatidylinositol 3–kinase SH2 domain reveals determinants of specificity
  158. Interleukin-10 stimulation of Phosphatidylinositol 3–kinase and p70 S6 kinase is required for the proliferative but not the antiinflammatory effects of the cytokine
  159. Heregulin Stimulates Mitogenesis and Phosphatidylinositol 3–kinase in Mouse Fibroblasts Transfected with erbB2/neu and erbB3 (∗)
  160. Phosphatidylinositol–3–kinase in isolated rat adipocytes. Activation by insulin and subcellular distribution.
  161. A Phosphatidylinositol 3–kinase is induced during soybean nodule organogenesis and is associated with membrane proliferation.
  162. A role for Phosphatidylinositol 3–kinase in the regulation of beta 1 integrin activity by the CD2 antigen.
  163. Association of Phosphatidylinositol 3–kinase with a specific sequence of the T cell receptor zeta chain is dependent on T cell activation.
  164. Interferon-α Engages the Insulin Receptor Substrate-1 to Associate with the Phosphatidylinositol 3′-kinase (∗)
  165. Platelet-derived growth factor-dependent activation of Phosphatidylinositol 3–kinase is regulated by receptor binding of SH2-domain-containing proteins which …
  166. Activation of Mitogen-activated Protein kinase and Phosphatidylinositol 3′-kinase Is Not Sufficient for the Hormonal Stimulation of Glucose Uptake …
  167. … through CD19 activates Vav/mitogen-activated protein kinase pathway and induces formation of a CD19/Vav/Phosphatidylinositol 3–kinase complex in human B cell …
  168. Novel functions of Phosphatidylinositol 3–kinase in terminally differentiated cells
  169. Phosphatidylinositol 3–kinase p85 SH2 domain specificity defined by direct phosphopeptide/SH2 domain binding
  170. Activation of the zeta isozyme of protein kinase C by Phosphatidylinositol 3, 4, 5-trisphosphate.
  171. … Mitogen-activated Protein kinase Activation by Platelet-activating Factor through a Mechanism Independent of p85/p110-type Phosphatidylinositol 3–kinase …
  172. Phosphatidylinositol 3–kinase and p70 s6 kinase participate in the regulation of protein turnover in skeletal muscle by insulin and insulin-like growth factor I
  173. Specific association of the β isoform of the p85 subunit of Phosphatidylinositol–3 kinase with the proto-oncogene c-cbl
  174. Insulin-mediated Targeting of Phosphatidylinositol 3–kinase to GLUT4-containing Vesicles (∗)
  175. HGF-mediated chemotaxis and tubulogenesis require activation of the Phosphatidylinositol 3–kinase
  176. CD28-mediated costimulation in the absence of Phosphatidylinositol 3–kinase association and activation
  177. Phosphatidylinositol 3–kinase functions upstream of Ras and Raf in mediating insulin stimulation of c-fos transcription
  178. Expression and characterization of the p85 subunit of the Phosphatidylinositol 3–kinase complex and a related p85β protein by using the baculovirus expression …
  179. Involvement of Phosphatidylinositol 3–kinase in the activation of extracellular signal-regulated kinase by PDGF in hepatic stellate cells
  180. Two Distinct Intracytoplasmic Regions of the T-cell Adhesion Molecule CD28 Participate in Phosphatidylinositol 3–kinase Association (∗)
  181. Receptor tyrosine kinase stimulates cell-matrix adhesion by Phosphatidylinositol 3 kinase and phospholipase C-gamma 1 pathways
  182. CD28 delivers costimulatory signals independently of its association with Phosphatidylinositol 3–kinase.
  183. Thrombin-dependent association of Phosphatidylinositol–3 kinase with p60c-src and p59fyn in human platelets
  184. Polyoma virus middle T antigen-pp60c-src complex associates with purified Phosphatidylinositol 3–kinase in vitro.
  185. ARIA/HRG regulates AChR epsilon subunit gene expression at the neuromuscular synapse via activation of Phosphatidylinositol 3–kinase and Ras/MAPK pathway.
  186. Brush Border Phosphatidylinositol 3–kinase Mediates Epidermal Growth Factor Stimulation of Intestinal NaCl Absorption and Na+/H+ Exchange (∗)
  187. Interaction of the Flt-1 Tyrosine kinase Receptor with the p85 Subunit of Phosphatidylinositol 3–kinase: MAPPING OF A NOVEL SITE INVOLVED IN BINDING …
  188. Activation of Phosphatidylinositol–3 kinase by ligation of the interleukin-7 receptor is dependent on protein tyrosine kinase activity
  189. … receptor activation of Phosphatidylinositol 3–kinase. von Willebrand factor stimulates the cytoskeletal association and activation of Phosphatidylinositol 3–kinase and …
  190. Fc receptor stimulation of Phosphatidylinositol 3–kinase in natural killer cells is associated with protein kinase C-independent granule release and cell-mediated …
  191. The C-terminal SH2 domain of p85 accounts for the high affinity and specificity of the binding of Phosphatidylinositol 3–kinase to phosphorylated platelet-derived …
  192. Interleukin‐7 induces the association of Phosphatidylinositol 3‐kinase with the α chain of the interleukin‐7 receptor
  193. A biosensor approach to probe the structure and function of the p85 alpha subunit of the Phosphatidylinositol 3–kinase complex
  194. ADP-ribosylation of rho p21 inhibits lysophosphatidic acid-induced protein tyrosine phosphorylation and Phosphatidylinositol 3–kinase activation in cultured …
  195. Activation of Phosphatidylinositol 3–kinase by epidermal growth factor, basic fibroblast growth factor, and nerve growth factor in PC12 pheochromocytoma cells.
  196. Insulin Stimulates Phosphatidylinositol‐3‐kinase activity in rat adipocytes
  197. Wortmannin binds specifically to 1-Phosphatidylinositol 3–kinase while inhibiting guanine nucleotide-binding protein-coupled receptor signaling in neutrophil …
  198. Erythropoietin-dependent association of Phosphatidylinositol 3–kinase with tyrosine-phosphorylated erythropoietin receptor.
  199. The colony stimulating factor-1 receptor associates with and activates Phosphatidylinositol–3 kinase
  200. Phosphatidylinositol–3 kinase and growth regulation
  201. Divergent regulation of Phosphatidylinositol 3–kinase P85 alpha and P85 beta isoforms upon T cell activation
  202. Insulin receptor substrate 1 binds two novel splice variants of the regulatory subunit of Phosphatidylinositol 3–kinase in muscle and brain
  203. Tumor Necrosis Factor Promotes Phosphorylation and Binding of Insulin Receptor Substrate 1 to Phosphatidylinositol 3–kinase in 3T3-L1 Adipocytes (∗)
  204. A region of the 85-kilodalton (kDa) subunit of Phosphatidylinositol 3–kinase binds the 110-kDa catalytic subunit in vivo
  205. Phosphatidylinositol 3–kinase acts at an intracellular membrane site to enhance GLUT4 exocytosis in 3T3-L1 cells
  206. Functional association of CD7 with Phosphatidylinositol 3–kinase: interaction via a YEDM motif
  207. Roles of 1-Phosphatidylinositol 3–kinase and ras in regulating translocation of GLUT4 in transfected rat adipose cells
  208. … within the alpha platelet-derived growth factor receptor kinase insert domain abrogate receptor-associated Phosphatidylinositol–3 kinase activity without affecting …
  209. Nuclear translocation of Phosphatidylinositol 3–kinase in rat pheochromocytoma PC 12 cells after treatment with nerve growth factor.
  210. Association of phosphorylated insulin-like growth factor-I receptor with the SH2 domains of Phosphatidylinositol 3–kinase p85.
  211. Phosphatidylinositol 3–kinase activity is required for hepatocyte growth factor-induced mitogenic signals in epithelial cells
  212. The insulin and insulin-like growth factor-I receptor substrate IRS-1 associates with and activates Phosphatidylinositol 3–kinase in vitro.
  213. An inhibitory role for Phosphatidylinositol 3–kinase in insulin secretion from pancreatic B cell line MIN6
  214. Rapid turnover of Phosphatidylinositol 3-phosphate in the green alga Chlamydomonas eugametos: signs of a phosphatidylinositide 3–kinase signalling pathway in …
  215. Ionizing Radiation Stimulates a Grb2-mediated Association of the Stress-activated Protein kinase with Phosphatidylinositol 3–kinase (∗)
  216. Essential role of Phosphatidylinositol 3‐kinase in insulin‐induced activation and phosphorylation of the cGMP‐inhibited cAMP phosphodiesterase in rat adipocytes …
  217. Inhibition of Phosphatidylinositol 3‐kinase blocks T cell antigen receptor/CD3‐induced activation of the mitogen‐activated kinase Erk2
  218. Insulin receptor substrate-1 mediates Phosphatidylinositol 3‘-kinase and p70S6k signaling during insulin, insulin-like growth factor-1, and interleukin-4 stimulation.
  219. Purification and characterization of a Phosphatidylinositol 3–kinase complex from bovine brain by using phosphopeptide affinity columns
  220. Association of the p85 regulatory subunit of Phosphatidylinositol 3–kinase with an essential erythropoietin receptor subdomain
  221. The cytoplasmic domain of CD28 is both necessary and sufficient for costimulation of interleukin-2 secretion and association with Phosphatidylinositol 3‘-kinase
  222. A Novel 55-kDa Regulatory Subunit for Phosphatidylinositol 3–kinase Structurally Similar to p55PIK Is Generated by Alternative Splicing of the p85α Gene (∗)
  223. The Phosphatidylinositol 3–kinase inhibitor wortmannin blocks mast cell exocytosis but not IL-6 production.
  224. In vivo binding properties of SH2 domains from GTPase-activating protein and Phosphatidylinositol 3–kinase
  225. … . Rapid induction of tyrosine phosphorylation, activation of syk tyrosine kinase, and phosphorylation of phospholipase C-gamma and Phosphatidylinositol 3–kinase.
  226. Wortmannin, a potent inhibitor of Phosphatidylinositol 3–kinase, inhibits osteoclastic bone resorption in vitro
  227. Structure and function of Phosphatidylinositol 3–kinase: a potential second messenger system involved in growth control
  228. Role of Phosphatidylinositol 3-OH-kinase activity in the inhibition of apoptosis in haemopoietic cells: Phosphatidylinositol 3-OH-kinase inhibitors reveal a difference in …
  229. Biochemical and pharmacological studies with KT7692 and LY294002 on the role of Phosphatidylinositol 3–kinase in FcεRI-mediated signal transduction
  230. The SH3 domain of p56lck is involved in binding to Phosphatidylinositol 3‘-kinase from T lymphocytes
  231. Activation of Phosphatidylinositol 3–kinase by prolactin in Nb2 cells
  232. Selective inhibition of p70 S6 kinase activation by Phosphatidylinositol 3‐kinase inhibitors
  233. Expression of Dominant Negative Mutant SHPTP2 Attenuates Phosphatidylinositol 3′-kinase Activity via Modulation of Phosphorylation of Insulin Receptor …
  234. Src-homology 3 domain of protein kinase p59fyn mediates binding to Phosphatidylinositol 3–kinase in T cells.
  235. Effect of the Activation of Phosphatidylinositol 3–kinase by a Thiophosphotyrosine Peptide on Glucose Transport in 3T3-L1 Adipocytes (∗)
  236. A mutational analysis of Phosphatidylinositol–3–kinase activation by human colony-stimulating factor-1 receptor
  237. Phosphatidylinositol–3 kinase is activated in v-src, v-yes, and v-fps transformed chicken embryo fibroblasts.
  238. Insulin-mediated inhibition of apolipoprotein B secretion requires an intracellular trafficking event and Phosphatidylinositol 3–kinase activation: studies with brefeldin A …
  239. Phosphatidylinositol 3–kinase, but Not p70/p85 Ribosomal S6 Protein kinase, Is Required for the Regulation of Phosphoenolpyruvate Carboxykinase …
  240. Activation of Phosphatidylinositol‐3‐kinase in Jurkat T cells depends on the presence of the p56lck tyrosine kinase
  241. Embryonic mesoderm cells spread in response to platelet-derived growth factor and signaling by Phosphatidylinositol 3–kinase.
  242. Inhibition of the signalling enzyme Phosphatidylinositol–3–kinase by antitumor ether lipid analogues
  243. Formation of c-Cbl· Phosphatidylinositol 3–kinase Complexes on Lymphocyte Membranes by a p56lck-independent Mechanism
  244. Activation of protein kinase C by Phosphatidylinositol 3, 4, 5-trisphosphate
  245. Activation of Phosphatidylinositol–3 kinase by ligation of the interleukin-7 receptor on human thymocytes.
  246. T Cell Activation-dependent Association between the p85 Subunit of the Phosphatidylinositol 3–kinase and Grb2/Phospholipase C-γ1-binding Phosphotyrosyl …
  247. Phosphatidylinositol 3–kinase-independent signal transduction pathway for platelet-derived growth factor-induced chemotaxis
  248. Microinjection of the SH2 domain of the 85-kilodalton subunit of Phosphatidylinositol 3–kinase inhibits insulin-induced DNA synthesis and c-fos expression
  249. Phosphatidylinositol 3–kinase activity is important for progesterone-induced Xenopus oocyte maturation
  250. Phosphatidylinositol 3–kinase is necessary and sufficient for insulin-stimulated stress fiber breakdown
  251. Interleukin-2 receptor regulates activation of Phosphatidylinositol 3–kinase
  252. … interact with the effector molecules phospholipase C-gamma 2, microtubule-associated protein kinase, GTPase-activating protein, and Phosphatidylinositol 3–kinase
  253. The Src-family kinase, Fyn, regulates the activation of Phosphatidylinositol 3–kinase in an interleukin 2-responsive T cell line.
  254. Insulin like growth factor-I induces limited association of Phosphatidylinositol 3–kinase to its receptor.
  255. Requirement for Phosphatidylinositol 3′-kinase Activity in Platelet-derived Growth Factor-stimulated Tyrosine Phosphorylation of p125 Focal Adhesion …
  256. PDGF-mediated activation of Phosphatidylinositol 3 kinase in human mesangial cells
  257. Direct association of p110 beta Phosphatidylinositol 3–kinase with p85 is mediated by an N-terminal fragment of p110 beta
  258. JAK3 protein tyrosine kinase mediates interleukin-7-induced activation of Phosphatidylinositol–3‘kinase
  259. Activation of Phosphatidylinositol–3 kinase by nerve growth factor involves indirect coupling of the trk proto-oncogene with src homology 2 domains
  260. … Receptor Stimulation and Interacts in Vivo with Fyn and Syk Tyrosine kinases, Grb2 and Shc Adaptors, and the p85 Subunit of Phosphatidylinositol 3–kinase …
  261. Signal transduction in neutrophil activation Phosphatidylinositol 3‐kinase is stimulated without tyrosine phosphorylation
  262. Insulin receptor substrate 1 is phosphorylated by the serine kinase activity of Phosphatidylinositol 3–kinase
  263. Different Effects of Insulin and Platelet‐Derived Growth Factor on Phosphatidylinositol 3‐kinase at the Subcellular Level in 3T3‐L1 Adipocytes: A Possible Explanation …
  264. … translation initiation factor 4E phosphorylation, and PHAS-I phosphorylation by insulin requires insulin receptor substrate 1 and Phosphatidylinositol 3–kinase
  265. A multiwell assay for inhibitors of Phosphatidylinositol–3–kinase and the identification of natural product inhibitors.
  266. Physiologic Levels of β‐Amyloid Activate Phosphatidylinositol 3‐kinase with the Involvement of Tyrosine Phosphorylation
  267. Regulation of Phosphatidylinositol 3–kinase by insulin in rat skeletal muscle
  268. … p120: demonstration of its identity with the c-cbl protooncogene product and in vivo complexes with Fyn, Grb2, and Phosphatidylinositol 3–kinase
  269. Evidence for a role of Phosphatidylinositol 3–kinase in the regulation of glucose transport in Xenopus oocytes.
  270. … Stimulates the Tyrosine Phosphorylation of the Insulin Receptor Substrate-1 and Its Association with Phosphatidylinositol 3–kinase in Primary Adipocytes (∗)
  271. Modification of the 85-kilodalton subunit of Phosphatidylinositol–3 kinase in platelet-derived growth factor-stimulated cells
  272. Regulation of insulin receptor, insulin receptor substrate-1 and Phosphatidylinositol 3–kinase in 3T3-F442A adipocytes. Effects of differentiation, insulin, and …
  273. IL-2 binding activates a tyrosine-phosphorylated Phosphatidylinositol–3–kinase.
  274. Phosphatidylinositol 3–kinase and the actin network are not required for the stimulation of glucose transport caused by mitochondrial uncoupling: comparison with …
  275. Extracellular human immunodeficiency virus type-1 Tat protein activates Phosphatidylinositol 3–kinase in PC12 neuronal cells
  276. Evidence that protein tyrosine kinase p56-Lck regulates the activity of Phosphatidylinositol–3‘-kinase in interleukin-2-dependent T-cells.
  277. Association of IRS-1 with the insulin receptor and the Phosphatidylinositol 3‘-kinase. Formation of binary and ternary signaling complexes in intact cells.
  278. Differential effects of okadaic acid on insulin-stimulated glucose and amino acid uptake and Phosphatidylinositol 3–kinase activity
  279. … a mitogen-activated protein kinase (ERK2) by the 5-hydroxytryptamine1A receptor is sensitive not only to inhibitors of Phosphatidylinositol 3–kinase, but to an …
  280. Association of Phosphatidylinositol 3–kinase, via the SH2 domains of p85, with focal adhesion kinase in polyoma middle t-transformed fibroblasts
  281. SH2-dependent association of Phosphatidylinositol 3‘-kinase 85-kDa regulatory subunit with the interleukin-2 receptor beta chain.
  282. Association between Phosphatidylinositol–3 kinase, Cbl and other tyrosine phosphorylated proteins in colony-stimulating factor-1-stimulated macrophages
  283. Phosphatidylinositol–3–kinase activity is required for the anti-Ig-mediated growth inhibition of a human B-lymphoma cell line
  284. Role of p85 subunit of Phosphatidylinositol–3–kinase as an adaptor molecule linking the insulin receptor, p62, and GTPase-activating protein.
  285. Interactions of polyomavirus middle T with the SH2 domains of the pp85 subunit of Phosphatidylinositol–3–kinase
  286. Association of activated Phosphatidylinositol 3–kinase with p120cbl in antigen receptor-ligated B cells
  287. The alpha-type 85-kDa subunit of Phosphatidylinositol 3–kinase is phosphorylated at tyrosines 368, 580, and 607 by the insulin receptor.
  288. Inhibition of Phosphatidylinositol–3′-kinase Prevents Induction of Endotoxin Tolerancein Vitro
  289. Synthesis and in Vitro Evaluation of New Wortmannin Esters:  Potent Inhibitors of Phosphatidylinositol 3–kinase
  290. Schizosaccharomyces pombe Vps34p, a Phosphatidylinositol-specific PI 3–kinase essential for normal cell growth and vacuole morphology
  291. Effects of growth factors on Phosphatidylinositol‐3 kinase in astroglial cells
  292. … -like growth factor induces phosphorylation of immunoreactive insulin receptor substrate and its association with Phosphatidylinositol–3 kinase in human thymocytes.
  293. Phosphatidylinositol 3′‐kinase associates with p145c‐kit as part of a cell type characteristic multimeric signalling complex.
  294. The Phosphatidylinositol 3–kinase inhibitor, wortmannin, inhibits insulin-induced activation of phosphatidylcholine hydrolysis and associated protein kinase C …
  295. Characterization of the bovine brain cytosolic Phosphatidylinositol 3–kinase complex
  296. Phosphatidylinositol 3–kinase activity is required for the activation process of focal adhesion kinase by platelet-derived growth factor
  297. Structure of a specific peptide complex of the carboxy‐terminal SH2 domain from the p85 alpha subunit of Phosphatidylinositol 3‐kinase.
  298. … characterization of Lnk, a signal transduction protein that links T-cell receptor activation signal to phospholipase C gamma 1, Grb2, and Phosphatidylinositol 3–kinase.
  299. Specific activity of Phosphatidylinositol 3–kinase is increased by insulin stimulation
  300. Mutations in the juxtamembrane region of the insulin receptor impair activation of Phosphatidylinositol 3–kinase by insulin
  301. CD38-mediated growth suppression of B-cell progenitors requires activation of Phosphatidylinositol 3–kinase and involves its association with the protein product of …
  302. Signal transduction by the hepatocyte growth factor receptor, c-met. Activation of the Phosphatidylinositol 3–kinase.
  303. Transformation-defective mutants of polyomavirus middle T antigen associate with Phosphatidylinositol 3–kinase (PI 3–kinase) but are unable to maintain wild-type …
  304. Structural features of the colony‐stimulating factor 1 receptor that affect its association with Phosphatidylinositol 3‐kinase.
  305. Activation of Na+/H+ exchange by platelet-derived growth factor involves Phosphatidylinositol 3‘-kinase and phospholipase C gamma.
  306. Disruption of GLUT1 glucose carrier trafficking in L6E9 and Sol8 myoblasts by the Phosphatidylinositol 3–kinase inhibitor wortmannin
  307. Phosphatidylinositol–3 kinase in fission yeast: a possible role in stress responses
  308. Insulin-dependent formation of a complex containing an 85-kDa subunit of Phosphatidylinositol 3–kinase and tyrosine-phosphorylated insulin receptor …
  309. Regulation by insulin of Phosphatidylinositol 3‘-kinase bound to alpha-and beta-isoforms of p85 regulatory subunit.
  310. Herbimycin A inhibits the association of p60v-src with the cytoskeletal structure and with Phosphatidylinositol 3‘kinase.
  311. Novel quinone antiproliferative inhibitors of Phosphatidylinositol–3–kinase.
  312. … and insulin-like growth factor-I actions in the bovine luteal cell: regulation of receptor tyrosine kinase activity, Phosphatidylinositol–3–kinase, and deoxyribonucleic acid …
  313. Oncostatin M activates Phosphatidylinositol–3–kinase in Kaposi’s sarcoma cells.
  314. Interleukin 2-and polyomavirus middle T antigen-induced modification of Phosphatidylinositol 3–kinase activity in activated T lymphocytes
  315. Erythropoietin induces the association of Phosphatidylinositol 3′‐kinase with a tyrosine‐phosphorylated protein complex containing the erythropoietin receptor
  316. Activation of pp70/85 S6 kinases in interleukin-2-responsive lymphoid cells is mediated by Phosphatidylinositol 3–kinase and inhibited by cyclic AMP
  317. In vitro association of Phosphatidylinositol 3–kinase activity with the activated insulin receptor tyrosine kinase.
  318. Phosphatidylinositol 3‐kinase activity is not essential for CD28 costimulatory activity in Jurkat T cells: studies with a selective inhibitor, wortmannin
  319. Effect of epidermal growth factor on Phosphatidylinositol 3–kinase activity in rabbit corneal epithelial cells
  320. Insulin-stimulated Phosphatidylinositol 3–kinase activity and 2-deoxy-D-glucose uptake in rat skeletal muscles
  321. Activation and nuclear translocation of mitogen-activated protein kinases by polyomavirus middle-T or serum depend on Phosphatidylinositol 3–kinase
  322. Localization of mRNA for Phosphatidylinositol 3–kinase in brain of developing and mature rats
  323. Phosphatidylinositol 3–kinase inhibitor, wortmannin, inhibits 5-hydroxytryptamine-mediated potentiation of platelet aggregation induced by epinephrine.
  324. The human gene encoding Phosphatidylinositol–3 kinase associated p85α is at chromosome region 5q12–13
  325. Role of p85 subunit of Phosphatidylinositol–3–kinase as an adaptor molecule linking the insulin receptor to insulin receptor substrate 1.
  326. An 11-Amino Acid Sequence from c-met Initiates Epithelial Chemotaxis via Phosphatidylinositol 3–kinase and Phospholipase C (∗)
  327. Specific binding of Fyn and Phosphatidylinositol 3‐kinase to the B cell surface glycoprotein CD19 through their src homology 2 domains
  328. … Interfere with Chemoattractant-induced Respiratory Burst in Neutrophils as a Result of the Inhibition of Phosphatidylinositol 3–kinase Rather than Receptor …
  329. Differential effects of spermine on Phosphatidylinositol 3–kinase and Phosphatidylinositol phosphate 5-kinase
  330. Angiotensin II induces tyrosine phosphorylation of insulin receptor substrate 1 and its association with Phosphatidylinositol 3–kinase in rat heart
  331. Cooperation of Src homology domains in the regulated binding of Phosphatidylinositol 3–kinase: a role for the Src homology 2 domain
  332. Evidence for a role of Phosphatidylinositol 3–kinase in IL-4-induced germline Cϵ transcription
  333. Lovastatin inhibits platelet-derived growth factor (PDGF) stimulation of Phosphatidylinositol 3–kinase activity as well as association of p85 subunit to tyrosine …
  334. Hepatocyte growth factor-induced proliferation of primary hepatocytes is mediated by activation of Phosphatidylinositol 3–kinase
  335. Platelet-derived growth factor activates membrane-associated Phosphatidylinositol 3–kinase and mediates its translocation from the cytosol. Detection of …
  336. Mutations in the SH3 domain of the src oncogene which decrease association of Phosphatidylinositol 3‘-kinase activity with pp60v-src and alter cellular morphology
  337. T cell receptor-associated alpha-Phosphatidylinositol 3–kinase becomes activated by T cell receptor cross-linking and requires pp56lck.
  338. … of the free catalytic p110 alpha and the complexed heterodimeric p110 alpha. p85 alpha forms of the mammalian Phosphatidylinositol 3–kinase.
  339. Translocation, Activation and Association of Protein‐tyrosine kinase (p72syk) with Phosphatidylinositol 3‐kinase are Early Events During Platelet Activation
  340. Molecular cloning of an amphibian insulin receptor substrate 1-like cDNA and involvement of Phosphatidylinositol 3–kinase in insulin-induced Xenopus oocyte …
  341. … colony-stimulating factor, but not IL-4, induce tyrosine phosphorylation, activation, and association of SHPTP2 with Grb2 and Phosphatidylinositol 3‘-kinase.
  342. Thrombin-stimulated immunoprecipitation of Phosphatidylinositol 3–kinase from human platelets.
  343. Regulation of phosphoinositide kinases in T cells. Evidence that Phosphatidylinositol 3–kinase is not a substrate for T cell antigen receptor-regulated tyrosine …
  344. Both CD28 ligands CD80 (B7-1) and CD86 (B7-2) activate Phosphatidylinositol 3–kinase, and wortmannin reveals heterogeneity in the regulation of T cell IL-2 …
  345. Enhanced gene expression for Phosphatidylinositol 3–kinase in the hypoglossal motoneurons following axonal crush
  346. Phosphatidylinositol 3–kinase
  347. Agonist-induced association of the p21rasGTPase-activating protein with Phosphatidylinositol 3–kinase
  348. Insulin induces a change in Rab5 subcellular localization in adipocytes independently of Phosphatidylinositol 3–kinase activation
  349. Cytoplasmic and nuclear localization sites of Phosphatidylinositol 3–kinase in human osteosarcoma sensitive and multidrug-resistant Saos-2 cells
  350. Functional interactions of Phosphatidylinositol 3–kinase with GTPase-activating protein in 3T3-L1 adipocytes
  351. Phosphatidylinositol–3′ kinase is not required for mitogenesis or internalization of the Flt3/Flk2 receptor tyrosine kinase
  352. … a cysteine residue in polyomavirus middle T antigen abolishes interactions with protein phosphatase 2A, pp60c-src, and Phosphatidylinositol–3 kinase, activation of c …
  353. Potent activation of Phosphatidylinositol 3‘-kinase by simple phosphotyrosine peptides derived from insulin receptor substrate 1 containing two YMXM motifs for …
  354. The insulin-elicited 60-kDa phosphotyrosine protein in rat adipocytes is associated with Phosphatidylinositol 3–kinase.
  355. Specific association of Phosphatidylinositol 3‐kinase with the protooncogene product Cbl in Fcγ receptor signaling
  356. Insulin and dexamethasone regulate insulin receptors, insulin receptor substrate-1, and Phosphatidylinositol 3–kinase in Fao hepatoma cells
  357. Phosphatidylinositol 3–kinase activity in murine erythroleukemia cells during DMSO-induced differentiation
  358. Activation of Src-family protein tyrosine kinases and Phosphatidylinositol 3–kinase in 3T3-L1 mouse preadipocytes by interleukin-11.
  359. The level of insulin receptor tyrosine kinase activity modulates the activities of Phosphatidylinositol 3–kinase, microtubule-associated protein, and S6 kinases.
  360. Wortmannin inhibits insulin secretion in pancreatic islets and β-TC3 cells independent of its inhibition of Phosphatidylinositol 3–kinase
  361. … derived growth factor triggers translocation of the insulin-regulatable glucose transporter (type 4) predominantly through Phosphatidylinositol 3–kinase binding sites on …
  362. Induction of activator protein (AP)-1 and nuclear factor-kappaB by CD28 stimulation involves both Phosphatidylinositol 3–kinase and acidic sphingomyelinase signals.
  363. CD28-mediated up-regulation of beta 1-integrin adhesion involves Phosphatidylinositol 3–kinase.
  364. The HIV-1 Nef Protein Interferes with Phosphatidylinositol 3–kinase Activation 1 (∗)
  365. Monocyte Colony-stimulating Factor Stimulates Binding of Phosphatidylinositol 3–kinase to Grb2· Sos Complexes in Human Monocytes
  366. The protein product of the proto-oncogene c-cbl forms a complex with Phosphatidylinositol 3–kinase p85 and CD19 in anti-IgM-stimulated human B-lymphoma …
  367. Potentiation of insulin stimulation of Phosphatidylinositol 3–kinase by thiazolidinedione-derived antidiabetic agents in Chinese hamster ovary cells expressing human …
  368. Modulation of the substrate specificity of the mammalian Phosphatidylinositol 3–kinase by cholesterol sulfate and sulfatide
  369. Insulin-stimulated oocyte maturation requires insulin receptor substrate 1 and interaction with the SH2 domains of Phosphatidylinositol 3–kinase
  370. Involvement of Phosphatidylinositol 3–kinase in stimulation of glucose transport by growth factors in 3T3-L1 adipocytes.
  371. 17β-hydroxywortmannin: A potent inhibitor of bone resorption and Phosphatidylinositol–3–kinase
  372. Activation of Phosphatidylinositol–3–kinase by platelet-derived growth factor and insulin-like growth factor-1 is inhibited by a transmembrane phosphotyrosine …
  373. CD28-mediated cytotoxicity by the human leukemic NK cell line YT involves tyrosine phosphorylation, activation of Phosphatidylinositol 3–kinase, and protein kinase C …
  374. Association of Phosphatidylinositol 3 kinase to protein kinase C ζ during interleukin‐2 stimulation
  375. Interaction of the molecular weight 85K regulatory subunit of the Phosphatidylinositol 3–kinase with the insulin receptor and the insulin-like growth factor-1 (IGF-I) …
  376. A tyrosine kinase signaling pathway accounts for the majority of Phosphatidylinositol 3, 4, 5-trisphosphate formation in chemoattractant-stimulated human …
  377. Phorbol ester treatment inhibits Phosphatidylinositol 3–kinase activation by, and association with, CD28, a T-lymphocyte surface receptor.
  378. Chromosomal localization of human p85 alpha, a subunit of Phosphatidylinositol 3–kinase, and its homologue p85 beta.
  379. Phosphatidylinositol 3′-kinase, but not p70 ribosomal S6 kinase, is involved in membrane protein recycling: wortmannin inhibits glucose transport and …
  380. Gastrin stimulates tyrosine phosphorylation of insulin receptor substrate 1 and its association with Grb2 and the Phosphatidylinositol 3–kinase
  381. Identification of amino acid residues required for a specific interaction between Src-tyrosine kinase and proline-rich region of Phosphatidylinositol–3′ kinase
  382. Studies with wortmannin suggest a role for Phosphatidylinositol 3–kinase in the activation of glycogen synthase and mitogen-activated protein kinase by insulin in rat …
  383. Insulin treatment stimulates the tyrosine phosphorylation of the alpha-type 85-kDa subunit of Phosphatidylinositol 3–kinase in vivo.
  384. NMR Analysis of Interactions of a Phosphatidylinositol 3 ‘-kinase SH2 Domain with Phosphotyrosine Peptides Reveals Interdependence of Major Binding Sites
  385. Endotoxin tolerance alters phospholipase C-γ1 and Phosphatidylinositol–3′-kinase expression in peritoneal macrophages
  386. … cytoplasmic domain of the interleukin-2 receptor beta chain is essential for interleukin-2-dependent tyrosine protein kinase and Phosphatidylinositol–3–kinase …
  387. Phosphatidylinositol–3–kinase is a non-tyrosine phosphorylated member of the insulin receptor signalling complex
  388. Activation of Phosphatidylinositol–3–kinase by insulin is mediated by both A and B human insulin receptor types
  389. CD28 co-stimulatory regimes differ in their dependence on Phosphatidylinositol 3–kinase: common co-signals induced by CD80 and CD86
  390. Naturally occurring ether‐linked phosphatidylcholine activates Phosphatidylinositol 3‐kinase and stimulates cell growth
  391. … colony-stimulating factor 1 receptor impairs mitogenesis without abrogating tyrosine kinase activity, association with Phosphatidylinositol 3–kinase, or induction of c …
  392. Interleukin-4 induces association of the c-fes proto-oncogene product with Phosphatidylinositol–3 kinase
  393. Cyclic peptide inhibitors of Phosphatidylinositol 3–kinase p85 SH2 domain binding
  394. Studies of partially transforming polyomavirus mutants establish a role for Phosphatidylinositol 3–kinase in activation of pp70 S6 kinase
  395. Lysophosphatidic acid stimulates glucose transport in Xenopus oocytes via a Phosphatidylinositol 3′-kinase with distinct properties
  396. Phosphatidylinositol 3-OH kinase activity is not required for activation of mitogen-activated protein kinase by cytokines
  397. Growth factor-regulated Phosphatidylinositol–3–kinase in astrocytes. Involvement of pp60c-Src.
  398. Selective inhibition of Phosphatidylinositol 3–kinase by phosphatidic acid and related lipids
  399. Evidence of the Involvement of Phosphatidylinositol 3–kinase in the Migration, Actin Stress Fiber Formation, and αvβ3-Integrin–Mediated Adherence of Human …
  400. The effects of wortmannin, a potent inhibitor of Phosphatidylinositol 3–kinase, on insulin-stimulated glucose transport, GLUT4 translocation, antilipolysis, and DNA …
  401. Phosphatidylinositol 3–kinase binding to polyoma virus middle tumor antigen mediates elevation of glucose transport by increasing translocation of the GLUT1 …
  402. Phosphatidylinositol 3–kinase participates in p56 (lck)/CD4-dependent down-regulation of LFA-1-mediated T cell adhesion.
  403. Wortmannin, a specific inhibitor of Phosphatidylinositol–3–kinase, inhibits erythropoietin-induced erythroid differentiation of K562 cells.
  404. Interleukin-4 (IL-4) induces protein tyrosine phosphorylation of the IL-4 receptor and association of Phosphatidylinositol 3–kinase to the IL-4 receptor in a mouse T cell …
  405. Mammalian Phosphatidylinositol 3′‐kinase induces a lethal phenotype on expression in Schizosaccharomyces pombe; comparison with the VPS34 gene product
  406. A role for Phosphatidylinositol 3–kinase in generating T cell help for B cell growth and differentiation.
  407. Insulin Stimulates Phosphatidylinositol 3‐kinase Activity in Rat Neuronal Primary Cultures
  408. Comparison of CD28‐B7. 1 and B7. 2 functional interaction in resting human T cells: Phosphatidylinositol 3‐kinase association to CD28 and cytokine production
  409. Tyrosine 508 of the 85-kilodalton subunit of Phosphatidylinositol 3–kinase is phosphorylated by the platelet-derived growth factor receptor
  410. Interleukin 7 receptor mediates the activation of Phosphatidylinositol–3 kinase in human B-cell precursors
  411. Association of Phosphatidylinositol 3‐kinase with the photo‐oncogene product Cbl upon CD38 ligation by a specific monoclonal antibody in THP‐1 cells
  412. Regulation of CD4-p561ck-associated Phosphatidylinositol 3–kinase (PI 3–kinase) and Phosphatidylinositol 4-kinase (PI 4-kinase)
  413. … in downstream signaling pathways of p185BCR-ABL in Ph+ ALL involve GTPase-activating protein, phospholipase C-gamma 1, and Phosphatidylinositol 3‘-kinase.
  414. … That Signals DNA Synthesis in NIH 3T3 Cells Specifically Binds a Complex of Src and Janus Family Tyrosine kinases and Phosphatidylinositol 3–kinase (∗)
  415. Anti-phosphotyrosine immunoprecipitation of Phosphatidylinositol 3′ kinase activity in different cell types after exposure to epidermal growth factor
  416. … B cell antigen receptor-related structure of pre-B cell lines induces tyrosine phosphorylation of p85 and p110 subunits and activation of Phosphatidylinositol 3–kinase
  417. The Gene That Encodes the Phosphatidylinositol–3 kinase Regulatory Subunit (p85α) Maps to Chromosome 13 in the Mouse
  418. The catalytic subunit of Phosphatidylinositol 3–kinase is a substrate for the activated platelet-derived growth factor receptor, but not for middle-T antigen-pp60c-src …
  419. Phosphatidylinositol 3 kinase activity is not essential for B7-1-mediated costimulation of proliferation or development of cytotoxicity in murine T cells.
  420. Effects of phorbol esters on insulin‐induced activation of Phosphatidylinositol 3‐kinase, glucose transport, and glycogen synthase in rat adipocytes
  421. The E5 gene product of rhesus papillomavirus is an activator of endogenous Ras and Phosphatidylinositol–3′-kinase in NIH 3T3 cells
  422. … by mutation of the tyrosine residues in the insulin receptor substrate-1 affecting association with the tyrosine phosphatase 2C and Phosphatidylinositol 3–kinase
  423. … site mutants in the murine colony-stimulating factor-1 receptor are unaffected in their ability to bind or phosphorylate Phosphatidylinositol–3 kinase but show differential …
  424. Insulin-like growth factor-1 stimulation of cells induces formation of complexes containing Phosphatidylinositol–3–kinase, guanosine triphosphatase-activating protein …
  425. Phosphatidylinositol 3–kinase
  426. Vps34p required for yeast vacuolar protein sorting is a multiple specificity kinase that exhibits both protein kinase and Phosphatidylinositol-specific PI 3–kinase …
  427. Wortmannin-mediated inhibition of Phosphatidylinositol 3–kinase activity triggers apoptosis in normal and neoplastic B lymphocytes which are in cell cycle
  428. … in 32D cells requires insulin receptor, Shc, and mitogen-activated protein kinase, but not insulin receptor substrate-1 and Phosphatidylinositol 3–kinase …
  429. … exerts a full insulin-like effect on glucose transport and glucose transporter 4 translocation in human adipocytes: evidence for a Phosphatidylinositol 3–kinase …
  430. Phosphatidylinositol 3–kinase: inhibition of intrinsic protein-serine kinase activity by phosphoinositides, and of lipid kinase activity by Mn2+
  431. Alternative binding of p56lck and Phosphatidylinositol 3–kinase in T cells by sulfhydryl oxidation: implication of aberrant signaling due to oxidative stress in T …
  432. Effect of IGF-I on Phosphatidylinositol 3–kinase in soleus muscle of lean and insulin-resistant obese mice
  433. Activation of Phosphatidylinositol 3–kinase and Phosphatidylinositol 4-kinase during rat parotid acinar cell proliferation
  434. A product of Phosphatidylinositol–3 kinase is elevated in dividing HT29 colonic epithelial cells
  435. Phosphorylation in vitro of the 85 kDa subunit of Phosphatidylinositol 3–kinase and its possible activation by insulin receptor tyrosine kinase
  436. Structure-activity studies of phosphorylated peptide inhibitors of the association of Phosphatidylinositol 3–kinase with PDGF-β receptor
  437. Mitogenic inhibition by phorbol esters is associated with decreased Phosphatidylinositol–3 kinase activation
  438. Structure of 85 kDa subunit of human Phosphatidylinositol 3‐kinase analyzed by using monoclonal antibodies
  439. Activation of Phosphatidylinositol 3–kinase by concanavalin A through dual signaling pathways, G-protein-coupled and phosphotyrosine-related, and an essential role …
  440. Rapid and efficient purification of Src homology 2 domain-containing proteins: Fyn, Csk and Phosphatidylinositol 3–kinase p85
  441. Activation of Akt by nerve growth factor via Phosphatidylinositol–3 kinase in PC12 pheochromocytoma cells
  442. SH3 domain-mediated dimerization of an n-terminal fragment of the Phosphatidylinositol 3–kinase p85 subunit
  443. EFFECT OF LOVASTATIN AND FLUOROMEVALONATE ON Phosphatidylinositol 3‐kinase ACTIVITY STIMULATED WITH PDGF
  444. … factor induces the tyrosine phosphorylation and activation of phospholipase C-gamma 1, Fyn and Lyn kinases, and Phosphatidylinositol 3–kinase in a human B cell …
  445. Protein kinase C-mediated formation of Phosphatidylinositol 3, 4-bisphosphate in human platelets
  446. EJ-Ras Inhibits Phospholipase Cγ1 but Not Actin Polymerization Induced by Platelet-Derived Growth Factor-BB via Phosphatidylinositol 3–kinase
  447. Controlled overexpression of selected domains of the P85 subunit of Phosphatidylinositol 3–kinase reverts v-Ha-Ras transformation
  448. Insulin-like growth factor-1-mediated association of p85 Phosphatidylinositol 3–kinase with pp 185: requirement of SH2 domains for in vivo interaction.
  449. The differential activation of Phosphatidylinositol–3 kinase and mitogen-activated protein kinases by PDGF-AA and IGF-I might explain the synergistic effect of the two …
  450. CD28‐dependent killing by human YT cells requires Phosphatidylinositol 3‐kinase activation
  451. Phosphoinositide 3-phosphatase segregates from Phosphatidylinositol 3–kinase in EGF-stimulated A431 cells and fails to in vitro hydrolyse Phosphatidylinositol (3, 4 …
  452. … p21ras-mediated signaling is independent of platelet-derived growth factor receptor interaction with GTPase-activating protein or Phosphatidylinositol–3–kinase.
  453. Synthesis of Phosphatidylinositol 3, 4-bisphosphate is regulated by protein-tyrosine phosphorylation but the p85α subunit of Phosphatidylinositol 3–kinase may not be …
  454. Peptide antisera to human colony-stimulating factor 1 receptor detect ligand-induced conformational changes and a binding site for Phosphatidylinositol 3–kinase
  455. Inhibition of IGF II-induced redistribution of mannose 6-phosphate receptors by the Phosphatidylinositol 3–kinase inhibitor, wortmannin
  456. A novel pathway for the formation of Phosphatidylinositol 3, 4-bisphosphate. Phosphorylation of Phosphatidylinositol 3-monophosphate by …
  457. Novel protein kinase/Phosphatidylinositol 3–kinase complex essential for receptor-mediated protein sorting to the vacuole in yeast
  458. Haematopoietic colony stimulating factors CSF-1 and GM-CSF increase Phosphatidylinositol 3–kinase activity in murine bone marrow-derived macrophages
  459. Isolation of the active form of RAC‐protein kinase (PKB/Akt) from transfected COS‐7 cells treated with heat shock stress and effects of Phosphatidylinositol 3, 4, 5 …
  460. Association of the insulin receptor and Phosphatidylinositol 3–kinase requires a third component
  461. Interleukin-4 activates two distinct pathways of Phosphatidylinositol–3 kinase in the same cells
  462. Dominant negative effect of the truncated p110 subunit of Phosphatidylinositol‐3 kinase
  463. … FTI-244 decreases platelet-derived growth factor receptor tyrosine phosphorylation levels and inhibits stimulation of Phosphatidylinositol 3–kinase but not mitogen …
  464. Inhibition of Neuroblastoma Cell Phosphatidylinositol 3‐kinase by CDP‐Diacylglycerol and Phosphatidate
  465. Regulation of Phosphatidylinositol–3 kinase by tyrosyl phosphoproteins
  466. D-myo-Inositol 1, 4, 5-trisphosphate analogues modified at the 3-position inhibit Phosphatidylinositol 3–kinase
  467. Detection of a 60 kDa tyrosine-phosphorylated protein in insulin-stimulated hepatoma cells that associates with the SH2 domain of Phosphatidylinositol 3–kinase
  468. Serine-rich region of the IL-2 receptor β-chain is required for activation of Phosphatidylinositol 3–kinase
  469. In vitro association of the Phosphatidylinositol 3‐kinase regulatory subunit (p85) with the human insulin receptor
  470. Phosphatidylinositol 3–kinase is involved in TRE-dependent gene expression in response to arginine vasopressin
  471. Dissociation of Phosphatidylinositol–3 kinase activity and mitogenic inhibition in vascular smooth muscle cells
  472. … H2O2 and vanadate enhances insulin receptor mediated tyrosine phosphorylation of IRS‐1 leading to IRS‐1 association with the Phosphatidylinositol 3‐kinase
  473. Characterization of a Phosphatidylinositol-specific phosphoinositide 3–kinase from mammalian cells
  474. Insulin-dependent Phosphatidylinositol 3′-kinase activity co-precipitates with insulin receptor in human circulating mononuclear cells
  475. Phosphatidylinositol (PI) 3–kinase and PI 4-kinase binding to the CD4-p56lck complex: the p56lck SH3 domain binds to PI 3–kinase but not PI 4-kinase
  476. O-17: Overexpression of a constitutively active form of Phosphatidylinositol 3 kinase is sufficient to Promote GLUT 4 translocation in transfected rat adipose cells
  477. Platelet-Derived Growth Factor Induces Phosphatidylinositol 3–kinase Release from the Middle T-pp60c-src Complex and Association with the Platelet-Derived …
  478. Phosphatidylinositol 3–kinase: A Novel Signal Transduction Pathway?
  479. Up-regulation of Expression of Phosphatidylinositol 3–kinase in Psoriatic Lesions
  480. A Phosphatidylinositol (PI) kinase gene family in Dictyostelium discoideum: biological roles of putative mammalian p110 and yeast Vps34p PI 3–kinase homologs …
  481. Differential roles of Phosphatidylinositol 3–kinase in mitogen-activated prote in kinase activation by insulin and epidermal growth factor
  482. Production of monoclonal antibodies specific to the carboxyl terminal region of the 85 kDa subunit of Phosphatidylinositol 3‐kinase: Use of the antibodies in …
  483. Phosphatidylinositol 3–kinase is involved in the colony-stimulating factor-1-induced spreading of macrophages and osteoclasts.
  484. Purification of Phosphatidylinositol 3–kinase by SDS-agarose gel electrophoresis and HPEC
  485. Does Phosphatidylinositol 3‐kinase play a role in insulin‐induced outgrowth of pseudopodial cables in cultured cells derived from micromeres of sea urchin embryos?
  486. Phosphatidylinositol–3–kinase Pathway is Stimulated by Fungal Lipid Containing Cocoa Butter Equivalents (CBE) in FMet-Leu-Phe (FMLP)-and Phorbolester (PMA) …
  487. A structural and functional analysis of the Phosphatidylinositol 3–kinase
  488. Engagement of the osteoclast integrin alpha v beta 3 by osteopontin stimulates Phosphatidylinositol 3-hydroxyl kinase activity
  489. O-49: A prevalent amino acid polymorphism at codon 325Met-> IIe in the gene encoding the Phosphatidylinositol 3–kinase p85α regulatory subunit is associated with …
  490. Activation of PRK1 by Phosphatidylinositol 4, 5-Bisphosphate and Phosphatidylinositol 3, 4, 5-Trisphosphate: A COMPARISON WITH PROTEIN kinase C …
  491. Characterization of tyrosine kinase-associated Phosphatidylinositol–3 kinase.
  492. The experimental study on Phosphatidylinositol 3–kinase/Akt in neural stem cells in vitro
  493. Phosphatidylinositol 3–kinase activation by IGF-I is independent of irs-1 in hl-60 cells
  494. Role of Phosphatidylinositol 3–kinase in growth factor and oncogene signaling
  495. Purification and characterisation of Phosphatidylinositol 3–kinase from bovine brain
  496. CD19 and Phosphatidylinositol 3–kinase
  497. Activation of Phosphatidylinositol 3–kinase in hepatocyte growth and hepatocellular transformation
  498. Phosphatidylinositol 3–kinase (PI3k) is required for chemoattractant-stimulated homotypic aggregation of human neutropfflls
  499. Shear stress-induced signal transduction through Phosphatidylinositol–3 kinase in endothelial cells
  500. Early events in insulin signaling: Tyrosine phosphorylation and Phosphatidylinositol 3–kinase activation
  501. Profilin and gelsolin stimulate Phosphatidylinositol 3–kinase activity
  502. Phosphatidylinositol 3–kinase Activity in 3T3-L1 Adipocytes: Effects of Pioglitazone on Insulin-and IGF-1-Stimulated Cells
  503. Phosphatidylinositol 3–kinase Activity Is Required for Hepatocyte Growth Factor-induced Mitogenic Signals in Epithelial Cells
  504. Role of Phosphatidylinositol 3–kinase during the first cell cycles of the sea urchin embryo. Effect on map kinase and MPF activities.
  505. P-62: Role of Phosphatidylinositol–3–kinase and S6 kinase in insulin-stimulated glycogen synthesis
  506. The effects of fluid shear stress on the activity of protein kinase C, Phosphatidylinositol 3–kinase and Rho in aortic endothelial cells
  507. Role of p38 and Phosphatidylinositol 3 kinase (PI3K) in the signal transduction of apoptosis of activated human?? T cells induced by restimulating with Mycobacterium …
  508. Phosphatidylinositol 3 kinase (PI 3 K) regulates glomerular mesangial cell chemotaxis and proliferation: Involvement of mitogen activated protein kinase (MAPK) …
  509. Phosphatidylinositol 3–kinase regulates actin stress fiber formation and the avidity of the integrin-receptor α, β 3 in human melanoma cells.
  510. Regulation of early endosomal transport and fusion by ADP-ribosylation factors and Phosphatidylinositol 3–kinase
  511. P-78: Role of p85 isoforms of Phosphatidylinositol–3–kinase in insulin receptor signaling
  512. Translocation of Phosphatidylinositol–3 kinase (PI3–kinase) and small GTPase Rho A to the cytoskeleton upon osteoclast attachment to bone.
  513. Phosphatidylinositol 3–kinase regulates actin stress fiber formation and the avidity of the integrin-receptor αvβ3 in human melanoma cells.
  514. Tyrosine residue 719 of the c-kit receptor is essential for binding of the P85 subunit of Phosphatidylinositol (PI) 3–kinase and for c-kit-associated PI 3–kinase activity in …
  515. … derived growth factor triggers translocation of the insulin-regulatable glucose transporter (type 4) predominantly through Phosphatidylinositol 3–kinase binding sites on …
  516. P-77: Insulinomimetic agent, vanadyl sulfate (VS)-stimulated Phosphatidylinositol 3–kinase (PI 3-K) and RAS/MAP kinase activation is independent of insulin receptor …
  517. Effect of phosphotyrosyl‐IRS‐1 level and insulin receptor tyrosine kinase activity on insulin‐stimulated Phosphatidylinositol 3, MAP, and S6 kinase activities
  518. Phosphorylation of Tyrosine 503 in the Erythropoietin Receptor (EpR) Is Essential for Binding the P85 Subunit of Phosphatidylinositol (PI) 3–kinase and for …
  519. Protein kinase B (c-Akt): a multifunctional mediator of Phosphatidylinositol 3–kinase activation
  520. A requirement for Phosphatidylinositol 3–kinase in pseudopod extension
  521. Downstream signalling events regulated by Phosphatidylinositol 3–kinase activity
  522. p110δ, a novel Phosphatidylinositol 3–kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes
  523. A specific product of Phosphatidylinositol 3–kinase directly activates the protein kinase Akt through its pleckstrin homology domain
  524. The role of Phosphatidylinositol 3–kinase in vascular endothelial growth factor signaling
  525. Cyclin D expression is controlled post-transcriptionally via a Phosphatidylinositol 3–kinase/Akt-dependent pathway
  526. Role of glycogen synthase kinase–3 in the Phosphatidylinositol 3–kinase/Akt cell survival pathway
  527. Antiapoptotic signalling by the insulin-like growth factor I receptor, Phosphatidylinositol 3–kinase, and Akt
  528. Calmodulin activates Phosphatidylinositol 3–kinase
  529. Phosphatidylinositol 3–kinase-dependent membrane association of the Bruton’s tyrosine kinase pleckstrin homology domain visualized in single living cells
  530. Regulation of the p85/p110 Phosphatidylinositol 3′-kinase: stabilization and inhibition of the p110α catalytic subunit by the p85 regulatory subunit
  531. Neuroprotection by brain-derived neurotrophic factor is mediated by extracellular signal-regulated kinase and Phosphatidylinositol 3–kinase
  532. Phosphatidylinositol 3–kinase couples the interleukin-2 receptor to the cell cycle regulator E2F
  533. Ezrin, a plasma membrane–microfilament linker, signals cell survival through the Phosphatidylinositol 3–kinase/Akt pathway
  534. Suppression of transforming growth factor-β-induced apoptosis through a Phosphatidylinositol 3–kinase/Akt-dependent pathway
  535. Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the Phosphatidylinositol 3–kinase/Akt pathway
  536. PTEN interactions with focal adhesion kinase and suppression of the extracellular matrix-dependent Phosphatidylinositol 3–kinase/Akt cell survival pathway
  537. Vascular endothelial growth factor regulates endothelial cell survival through the Phosphatidylinositol 3′-kinase/Akt signal transduction pathway …
  538. Depolarization and neurotrophins converge on the Phosphatidylinositol 3–kinase–Akt pathway to synergistically regulate neuronal survival
  539. Relationship between flavonoid structure and inhibition of Phosphatidylinositol 3–kinase: a comparison with tyrosine kinase and protein kinase C inhibition
  540. Myogenic signaling of Phosphatidylinositol 3–kinase requires the serine-threonine kinase Akt/protein kinase B
  541. Requirement of Phosphatidylinositol 3–kinase in focal adhesion kinase-promoted cell migration
  542. Identification of an early endosomal protein regulated by Phosphatidylinositol 3–kinase
  543. Activation of the Phosphatidylinositol 3–kinase serine kinase by IFN-alpha.
  544. The Phosphatidylinositol 3‐kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes
  545. Constitutive activation of Phosphatidylinositol 3–kinase by a naturally occurring mutant epidermal growth factor receptor
  546. Akt, a target of Phosphatidylinositol 3–kinase, inhibits apoptosis in a differentiating neuronal cell line
  547. Regulation of the p85/p110α Phosphatidylinositol 3′-kinase: distinct roles for the N-terminal and C-terminal SH2 domains
  548. Activated Phosphatidylinositol 3–kinase and Akt kinase promote survival of superior cervical neurons
  549. Increased levels of Phosphatidylinositol 3‐kinase activity in colorectal tumors
  550. Protein kinase C-ζ as a downstream effector of Phosphatidylinositol 3–kinase during insulin stimulation in rat adipocytes: potential role in glucose transport
  551. Phosphatidylinositol 3–kinase and Akt protein kinase are necessary and sufficient for the survival of nerve growth factor-dependent sympathetic neurons
  552. Phosphatidylinositol 3‐kinase‐mediated regulation of neuronal apoptosis and necrosis by insulin and IGF‐I
  553. Identification and analysis of PH domain-containing targets of Phosphatidylinositol 3–kinase using a novel in vivo assay in yeast
  554. Phosphatidylinositol 3–kinase is required for integrin-stimulated AKT and Raf-1/mitogen-activated protein kinase pathway activation
  555. Comparison of the roles of mitogen-activated protein kinase kinase and Phosphatidylinositol 3–kinase signal transduction in neutrophil effector function
  556. Activation of Phosphatidylinositol 3–kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-κB p65/RelA subunit
  557. Induction of Vascular Endothelial Growth Factor by Hypoxia Is Modulated by a Phosphatidylinositol 3–kinase/Akt Signaling Pathway in Ha-ras-Transformed Cells …
  558. Activation of Phosphatidylinositol 3–kinase is sufficient for cell cycle entry and promotes cellular changes characteristic of oncogenic transformation
  559. STAT3 as an adapter to couple Phosphatidylinositol 3–kinase to the IFNAR1 chain of the type I interferon receptor
  560. Insulin-dependent translocation of ARNO to the plasma membrane of adipocytes requires Phosphatidylinositol 3–kinase
  561. Heregulin induces phosphorylation of BRCA1 through Phosphatidylinositol 3–kinase/AKT in breast cancer cells
  562. Phosphatidylinositol 3–kinase is required for platelet-derived growth factor’s actions on hepatic stellate cells
  563. FAK is the upstream signal protein of the Phosphatidylinositol 3–kinase-Akt survival pathway in hydrogen peroxide-induced apoptosis of a human …
  564. An essential role of Phosphatidylinositol 3–kinase in myogenic differentiation
  565. Phosphatidylinositol 3–kinase-γ activates Bruton’s tyrosine kinase in concert with Src family kinases
  566. Phosphatidylinositol 3–kinase in interleukin 1 signaling: physical interaction with the interleukin 1 receptor and requirement in NFκB and AP-1 activation
  567. Insulin-like growth factor 1 inhibits apoptosis using the Phosphatidylinositol 3′-kinase and mitogen-activated protein kinase pathways
  568. The Phosphatidylinositol 3′-kinase pathway is a dominant growth factor-activated cell survival pathway in LNCaP human prostate carcinoma cells
  569. … the protein kinase Akt/PKB by the formation of E-cadherin-mediated cell-cell junctions: evidence for the association of Phosphatidylinositol 3–kinase with the E …
  570. Angiotensin II activates Phosphatidylinositol 3–kinase in vascular smooth muscle cells
  571. p85α gene generates three isoforms of regulatory subunit for Phosphatidylinositol 3–kinase (PI 3–kinase), p50α, p55α, and p85α, with different PI 3–kinase …
  572. Effects of free fatty acids on glucose transport and IRS-1–associated Phosphatidylinositol 3–kinase activity
  573. Nitric oxide stimulates skeletal muscle glucose transport through a calcium/contraction–and Phosphatidylinositol–3–kinase–independent pathway
  574. Adenoviral gene transfer of activated Phosphatidylinositol 3′-kinase and Akt inhibits apoptosis of hypoxic cardiomyocytes in vitro
  575. Interleukin 8-stimulated Phosphatidylinositol–3–kinase activity regulates the migration of human neutrophils independent of extracellular signal-regulated kinase and …
  576. Differentiated phenotype of smooth muscle cells depends on signaling pathways through insulin-like growth factors and Phosphatidylinositol 3–kinase
  577. The protein-tyrosine phosphatase TCPTP regulates epidermal growth factor receptor-mediated and Phosphatidylinositol 3–kinase-dependent signaling
  578. Inhibition of adipose differentiation by Phosphatidylinositol 3‐kinase inhibitors
  579. Induction of vascular endothelial growth factor expression in endothelial cells by platelet-derived growth factor through the activation of Phosphatidylinositol 3–kinase
  580. Midkine inhibits caspase-dependent apoptosis via the activation of mitogen-activated protein kinase and Phosphatidylinositol 3–kinase in cultured neurons.
  581. Phosphatidylinositol 3–kinase links the interleukin-2 receptor to protein kinase B and p70 S6 kinase
  582. Distinct roles of the Phosphatidylinositol 3–kinase and STAT5 pathways in IL-7-mediated development of human thymocyte precursors
  583. MAP kinases, Phosphatidylinositol 3‐kinase, and p70 S6 kinase mediate the mitogenic response of human endothelial cells to vascular endothelial growth factor
  584. Requirement for both Shc and Phosphatidylinositol 3′ kinase signaling pathways in polyomavirus middle T-mediated mammary tumorigenesis
  585. Negative regulation by Phosphatidylinositol 3–kinase of inducible nitric oxide synthase expression in macrophages
  586. c-Src is required for stimulation of gelsolin-associated Phosphatidylinositol 3–kinase
  587. Altered expression levels and impaired steps in the pathway to Phosphatidylinositol 3–kinase activation via insulin receptor substrates 1 and 2 in Zucker fatty rats
  588. Contribution of Phosphatidylinositol 3‐kinase to radiation resistance in human melanoma cells
  589. Lysophosphatidic acid is a major serum noncytokine survival factor for murine macrophages which acts via the Phosphatidylinositol 3–kinase signaling pathway.
  590. Increase in nuclear Phosphatidylinositol 3‐kinase activity and Phosphatidylinositol (3, 4, 5) trisphosphate synthesis precede PKC‐ζ translocation to the nucleus of NGF …
  591. Src-induced activation of inducible T cell kinase (ITK) requires Phosphatidylinositol 3–kinase activity and the Pleckstrin homology domain of inducible T cell kinase
  592. Epidermal growth factor promotes MDA-MB-231 breast cancer cell migration through a Phosphatidylinositol 3′-kinase and phospholipase C-dependent mechanism
  593. … oxide synthase phosphorylation sites by mass spectrometry and regulation of phosphorylation and nitric oxide production by the Phosphatidylinositol 3–kinase …
  594. Matrix-dependent Tiam1/Rac signaling in epithelial cells promotes either cell–cell adhesion or cell migration and is regulated by Phosphatidylinositol 3–kinase
  595. Platelet-derived growth factor β receptor regulates interstitial fluid homeostasis through Phosphatidylinositol–3′ kinase signaling
  596. Wortmannin, a specific inhibitor of Phosphatidylinositol–3–kinase, enhances LPS-induced NO production from murine peritoneal macrophages
  597. Antiapoptotic signaling in LNCaP prostate cancer cells: a survival signaling pathway independent of Phosphatidylinositol 3′-kinase and Akt/protein kinase B
  598. Extracellular‐regulated kinases and Phosphatidylinositol 3‐kinase are involved in brain‐derived neurotrophic factor‐mediated survival and neuritogenesis of the …
  599. Phosphatidylinositol 3–kinase mediates mitogen-induced human airway smooth muscle cell proliferation
  600. Phosphatidylinositol 3‐kinase is recruited to a specific site in the activated IL‐1 receptor I
  601. Phosphatidylinositol 3–kinase is a negative regulator of cellular differentiation
  602. Etk/Bmx, a tyrosine kinase with a pleckstrin-homology domain, is an effector of Phosphatidylinositol 3′-kinase and is involved in interleukin 6-induced …
  603. Tyrosine 1101 of Tie2 is the major site of association of p85 and is required for activation of Phosphatidylinositol 3–kinase and Akt
  604. The Antiapoptotic Gene mcl-1 Is Up-Regulated by the Phosphatidylinositol 3–kinase/Akt Signaling Pathway through a Transcription Factor Complex Containing …
  605. Cyclin D1 Expression Mediated by Phosphatidylinositol 3–kinase through mTOR-p70S6K-Independent Signaling in Growth Factor-Stimulated NIH 3T3 Fibroblasts
  606. Regulation of vascular smooth muscle cell apoptosis: modulation of Bad by a Phosphatidylinositol 3–kinase–dependent pathway
  607. Activated MEK stimulates expression of AP-1 components independently of Phosphatidylinositol 3–kinase (PI3–kinase) but requires a PI3–kinase signal to stimulate …
  608. Phosphatidylinositol 3–kinase mediates epidermal growth factor-induced activation of the c-Jun N-terminal kinase signaling pathway
  609. Distinct Phosphatidylinositol 3–kinase lipid products accumulate upon oxidative and osmotic stress and lead to different cellular responses
  610. Activation of Phosphatidylinositol 3–kinase through glycoprotein 130 induces protein kinase B and p70 S6 kinase phosphorylation in cardiac myocytes
  611. Inhibition of Phosphatidylinositol 3–kinase activity blocks depolarization-and insulin-like growth factor I-mediated survival of cerebellar granule cells
  612. Heregulin regulates cytoskeletal reorganization and cell migration through the p21-activated kinase-1 via Phosphatidylinositol–3 kinase
  613. p70s6k Integrates Phosphatidylinositol 3–kinase and Rapamycin-Regulated Signals for E2F Regulation in T Lymphocytes
  614. Inhibition of Phosphatidylinositol 3–kinase activity by adenovirus-mediated gene transfer and its effect on insulin action
  615. … -permeable AMPA receptors induce phosphorylation of cAMP response element-binding protein through a Phosphatidylinositol 3–kinase-dependent stimulation of the …
  616. Insulin stimulation of the fatty acid synthase promoter is mediated by the Phosphatidylinositol 3–kinase pathway: involvement of protein kinase B/Akt
  617. Phosphatidylinositol 3–kinase γ mediates shear stress-dependent activation of JNK in endothelial cells
  618. Hyperglycemia inhibits insulin activation of Akt/protein kinase B but not Phosphatidylinositol 3–kinase in rat skeletal muscle.
  619. αPIX nucleotide exchange factor is activated by interaction with Phosphatidylinositol 3–kinase
  620. Insulin receptor substrate-1 phosphorylation and Phosphatidylinositol 3–kinase activity in skeletal muscle from NIDDM subjects after in vivo insulin stimulation
  621. Dedifferentiation of adenocarcinomas by activation of Phosphatidylinositol 3–kinase
  622. Role of Phosphatidylinositol 3–kinase activation in the hypertrophic growth of adult ventricular cardiomyocytes
  623. A redox-triggered ras-effector interaction: recruitment of Phosphatidylinositol 3′-kinase to Ras by redox stress
  624. Intermolecular interactions of the p85α regulatory subunit of Phosphatidylinositol 3–kinase
  625. Vac1p coordinates Rab and Phosphatidylinositol 3–kinase signaling in Vps45p-dependent vesicle docking/fusion at the endosome
  626. Requirement of Phosphatidylinositol–3 kinase for activation of JNK/SAPKs by PDGF
  627. 1α,25-Dihydroxyvitamin D3–Induced Myeloid Cell Differentiation Is Regulated by a Vitamin D Receptor–Phosphatidylinositol 3–kinase Signaling Complex
  628. Oxidative stress disrupts insulin-induced cellular redistribution of insulin receptor substrate-1 and Phosphatidylinositol 3–kinase in 3T3-L1 adipocytes: a …
  629. … rescue cerebellar granule neurons from oxidative stress‐mediated apoptotic death: selective involvement of Phosphatidylinositol 3‐kinase and the mitogen‐activated …
  630. Phosphatidylinositol 3–kinase activation is required for insulin-stimulated sodium transport in A6 cells
  631. Requirement of Phosphatidylinositol 3–kinase-dependent pathway and Src for Gas6-Axl mitogenic and survival activities in NIH 3T3 fibroblasts
  632. The p85 subunit of Phosphatidylinositol 3–kinase associates with the Fc receptor γ-chain and linker for activitor of T cells (LAT) in platelets stimulated by …
  633. Phosphatidylinositol 3–kinase-dependent activation of protein kinase C-ζ in bacterial lipopolysaccharide-treated human monocytes
  634. Expression of a constitutively active Phosphatidylinositol 3–kinase induces process formation in rat PC12 cells: use of Cre/loxP recombination system
  635. Inhibition of Phosphatidylinositol 3–kinase induces nitric-oxide synthase in lipopolysaccharide-or cytokine-stimulated C6 glial cells
  636. Receptors of the glial cell line-derived neurotrophic factor family of neurotrophic factors signal cell survival through the Phosphatidylinositol 3–kinase pathway in spinal …
  637. AKT2, a Member of the Protein kinase B Family, Is Activated by Growth Factors, v-Ha-ras, and v-src through Phosphatidylinositol 3–kinase in Human Ovarian …
  638. Activation of protein kinase C-ζ and Phosphatidylinositol 3′-kinase and promotion of macrophage differentiation by insulin-like growth factor-I
  639. Phosphatidylinositol 3–kinase contributes to Erk1/Erk2 MAP kinase activation associated with hepatocyte growth factor-induced cell scattering
  640. Downstream of Phosphatidylinositol–3 kinase, a multifunctional signaling molecule, and its regulation in cell responses
  641. Human dopamine D3 receptors mediate mitogen-activated protein kinase activation via a Phosphatidylinositol 3–kinase and an atypical protein kinase C-dependent …
  642. Phosphatidylinositol‐3 kinase is involved in ruffled border formation in osteoclasts
  643. Membrane-targeted Phosphatidylinositol 3–kinase mimics insulin actions and induces a state of cellular insulin resistance
  644. A function for Phosphatidylinositol 3–kinase β (p85α-p110β) in fibroblasts during mitogenesis: requirement for insulin-and lysophosphatidic acid-mediated signal …
  645. Phosphatidylinositol 3‐kinase and Akt protein kinase mediate IGF‐I‐and prosaptide‐induced survival in Schwann cells
  646. Activation of Phosphatidylinositol 3‐kinase, but not extracellular‐regulated kinases, is necessary to mediate brain‐derived neurotrophic factor‐induced motoneuron …
  647. Phosphatidylinositol 3–kinase contributes to cell volume regulation through effects on ATP release
  648. Phosphatidylinositol 3–kinase is required for the formation of constitutive transport vesicles from the TGN
  649. Enhanced Phosphatidylinositol 3–kinase activity and high phosphorylation state of its downstream signalling molecules mediated by ret with the MEN 2B mutation
  650. A collagen-related peptide regulates phospholipase Cγ2 via Phosphatidylinositol 3–kinase in human platelets
  651. Phosphatidylinositol 3‐kinase: increased activity and protein level in amyotrophic lateral sclerosis
  652. Enhanced insulin-stimulated activation of Phosphatidylinositol 3–kinase in the liver of high-fat-fed rats.
  653. SHP-1 regulates Lck-induced Phosphatidylinositol 3–kinase phosphorylation and activity
  654. Insulin-like growth factors require Phosphatidylinositol 3–kinase to signal myogenesis: dominant negative p85 expression blocks differentiation of L6E9 muscle cells
  655. DHEA improves glucose uptake via activations of protein kinase C and Phosphatidylinositol 3–kinase
  656. Insulin-like growth factor-II, Phosphatidylinositol 3–kinase, nuclear factor-κB and inducible nitric-oxide synthase define a common myogenic signaling pathway
  657. Phosphorylation of CD19 Y484 and Y515, and linked activation of Phosphatidylinositol 3–kinase, are required for B cell antigen receptor-mediated activation of …
  658. The B cell antigen receptor activates the Akt (protein kinase B)/glycogen synthase kinase–3 signaling pathway via Phosphatidylinositol 3–kinase
  659. Endosomal recycling of the Na+/H+ exchanger NHE3 isoform is regulated by the Phosphatidylinositol 3–kinase pathway
  660. Differential effects of constitutively active Phosphatidylinositol 3–kinase on glucose transport, glycogen synthase activity, and DNA synthesis in 3T3-L1 adipocytes
  661. Interleukin-6 inhibits transforming growth factor-β-induced apoptosis through the Phosphatidylinositol 3–kinase/Akt and signal transducers and activators of …
  662. … in response to dexamethasone is associated with inhibition of insulin-like growth factor-I stimulated Phosphatidylinositol 3–kinase activity in cultured muscle …
  663. Requirement for Phosphatidylinositol–3′-kinase in cytokine-mediated germ cell survival during fetal oogenesis in the mouse
  664. Insulin receptor substrate (IRS) 1 is reduced and IRS-2 is the main docking protein for Phosphatidylinositol 3–kinase in adipocytes from subjects with non-insulin …
  665. Defective regulation of Phosphatidylinositol–3–kinase gene expression in skeletal muscle and adipose tissue of non-insulin-dependent diabetes mellitus patients
  666. … transporter mRNAs in response to insulin: role of mammalian target of rapamycin, protein kinase b, and Phosphatidylinositol 3–kinase in GLUT1 mRNA …
  667. Grb2-associated binder-1 mediates Phosphatidylinositol 3–kinase activation and the promotion of cell survival by nerve growth factor
  668. Phosphorylation–dependent interaction of the N‐methyl‐ d‐aspartate receptor ε2 subunit with Phosphatidylinositol 3‐kinase
  669. Differential regulation of insulin receptor substrates-1 and-2 (IRS-1 and IRS-2) and Phosphatidylinositol 3–kinase isoforms in liver and muscle of the obese diabetic (ob …
  670. Phosphatidylinositol 3–kinase-mediated Endocytosis of Renal Na+,K+-ATPase α Subunit in Response to Dopamine
  671. Involvement of Phosphatidylinositol 3–kinase in stromal cell-derived factor-1α-induced lymphocyte polarization and chemotaxis
  672. Protein kinase B (c-Akt), Phosphatidylinositol 3–kinase, and STAT5 are activated by erythropoietin (EPO) in HCD57 erythroid cells but are constitutively active in an …
  673. Hepatocyte growth factor promotes migration of human hepatocellular carcinoma via Phosphatidylinositol 3–kinase
  674. Inhibition of Phosphatidylinositol–3–kinase blocks development of functional embryonic cardiomyocytes
  675. … prolactin stimulate tyrosine phosphorylation of insulin receptor substrate-1,-2, and-3, their association with p85 Phosphatidylinositol 3–kinase (PI3–kinase), and …
  676. Roles of Phosphatidylinositol 3–kinase and mitogen-activated protein kinase pathways in stimulation of vascular smooth muscle cell migration and deoxyriboncleic …
  677. TGF-β1 modulates EGF-stimulated Phosphatidylinositol 3–kinase activity in human airway smooth muscle cells
  678. Phosphatidylinositol 3–kinase is involved in the protection of primary cultured human erythroid precursor cells from apoptosis
  679. Phosphatidylinositol 3–kinase is a target for protein tyrosine nitration
  680. Phosphatidylinositol–3 kinase is necessary for 12-O-tetradecanoylphorbol-13-acetate-induced cell transformation and activated protein 1 activation
  681. p21 ras and Phosphatidylinositol–3 kinase are required for survival of wild-type and NF1 mutant sensory neurons
  682. Modulation of insulin receptor substrate-1 tyrosine phosphorylation by an Akt/Phosphatidylinositol 3–kinase pathway
  683. … -activated protein kinase activation through Fcε receptor I and stem cell factor receptor is differentially regulated by Phosphatidylinositol 3–kinase and calcineurin in …
  684. Microinjection of activated Phosphatidylinositol–3 kinase induces process outgrowth in rat PC12 cells through the Rac-JNK signal transduction pathway
  685. Prolactin induced tyrosine phosphorylation of p59fyn may mediate Phosphatidylinositol 3–kinase activation in Nb2 cells.
  686. Glucagon-like peptide-1 promotes DNA synthesis, activates Phosphatidylinositol 3–kinase and increases transcription factor pancreatic and duodenal homeobox gene …
  687. Phosphatidylinositol 3–kinase is involved in the induction of macrophage growth by oxidized low density lipoprotein
  688. Phosphatidylinositol 3–kinase Requirement in Activation of the ras/C-raf-1/MEK/ERK and p70s6k Signaling Cascade by the Insulinomimetic Agent Vanadyl Sulfate
  689. Ataxia‐telangiectasia without immunodeficiency: Novel point mutations within and adjacent to the Phosphatidylinositol 3‐kinase‐like domain
  690. Steel factor induces tyrosine phosphorylation of CRKL and binding of CRKL to a complex containing c-Kit, Phosphatidylinositol 3–kinase, and p120CBL
  691. Modification of Phosphatidylinositol 3–kinase SH2 domain binding properties by Abl-or Lck-mediated tyrosine phosphorylation at Tyr-688
  692. Identification of a common amino acid polymorphism in the p85α regulatory subunit of Phosphatidylinositol 3–kinase: effects on glucose disappearance constant …
  693. Region‐specific mRNA expression of Phosphatidylinositol 3‐kinase regulatory isoforms in the central nervous system of C57BL/6J mice
  694. Heat shock activates c-Src tyrosine kinases and Phosphatidylinositol 3–kinase in NIH3T3 fibroblasts
  695. Evidence of a role for Phosphatidylinositol 3–kinase activation in the blocking of apoptosis by polyomavirus middle T antigen
  696. Comparative Effects of GTPγS and Insulin on the Activation of Rho, Phosphatidylinositol 3–kinase, and Protein kinase N in Rat Adipocytes: RELATIONSHIP …
  697. Nerve growth factor protects PC12 cells against peroxynitrite‐induced apoptosis via a mechanism dependent on Phosphatidylinositol 3‐kinase
  698. Activation of Phosphatidylinositol 3–kinase, protein kinase B, and p70 S6 kinases in lipopolysaccharide-stimulated Raw 264.7 cells: differential effects of rapamycin …
  699. Phosphatidylinositol 3–kinase association with the osteoclast cytoskeleton, and its involvement in osteoclast attachment and spreading
  700. … of the ADP-ribosylation factor-exchange factor GRP1 to the plasma membrane of PC12 cells requires activation of Phosphatidylinositol 3–kinase and the GRP1 …
  701. Thymocyte activation induces the association of Phosphatidylinositol 3‐kinase and pp120 with CD5
  702. Heregulin β1-activated Phosphatidylinositol 3–kinase enhances aggregation of MCF-7 breast cancer cells independent of extracellular signal-regulated kinase
  703. Phosphatidylinositol 3–kinase Is Required for Growth Factor–Induced Amino Acid Uptake by Vascular Smooth Muscle Cells
  704. The proto-oncogene product p120cbl links c-Src and Phosphatidylinositol 3′-kinase to the integrin signaling pathway
  705. CD28 receptor endocytosis is targeted by mutations that disrupt Phosphatidylinositol 3–kinase binding and costimulation
  706. Protein kinase B/Akt is activated by polyomavirus middle-T antigen via a Phosphatidylinositol 3–kinase-dependent mechanism
  707. Assessment of the roles of mitogen-activated protein kinase, Phosphatidylinositol 3–kinase, protein kinase B, and protein kinase C in insulin inhibition of cAMP …
  708. Thrombopoietin induces activation of the Phosphatidylinositol‐3′ kinase pathway and formation of a complex containing p85PI3K and the protooncoprotein p120CBL
  709. Signaling through CD5 activates a pathway involving Phosphatidylinositol 3–kinase, Vav, and Rac1 in human mature T lymphocytes
  710. Tyrosine phosphorylation of p120cbl in BCR/abl transformed hematopoietic cells mediates enhanced association with Phosphatidylinositol 3–kinase
  711. Erythropoietin induces the tyrosine phosphorylation of GAB1 and its association with SHC, SHP2, SHIP, and Phosphatidylinositol 3–kinase
  712. Epidermal growth factor modulates tyrosine phosphorylation of p130Cas: involvement of Phosphatidylinositol 3′-kinase and actin cytoskeleton
  713. Phosphatidylinositol 3′-kinase and SH2-containing inositol phosphatase (SHIP) are recruited by distinct positive and negative growth-regulatory domains in the …
  714. Selective up-regulation of Phosphatidylinositol 3′-kinase activity in Th2 cells inhibits caspase-8 cleavage at the death-inducing complex: a mechanism for Th2 …
  715. Inhibition of Phosphatidylinositol 3–kinase activity elevates c-Jun N-terminal kinase activity in apoptosis of cultured cerebellar granule neurons
  716. Vanadyl sulfate-stimulated glycogen synthesis is associated with activation of Phosphatidylinositol 3–kinase and is independent of insulin receptor tyrosine …
  717. Phosphatidylinositol 3–kinase-dependent and-independent cytolytic effector functions
  718. Activation of Phosphatidylinositol 3–kinase by interleukin-13: an inhibitory signal for inducible nitric-oxide synthase expression in epithelial cell line HT-29
  719. G1 phase arrest by the Phosphatidylinositol 3–kinase inhibitor LY 294002 is correlated to up-regulation of p27Kip1 and inhibition of G1 CDKs in choroidal …
  720. Phosphatidylinositol 3′-kinase-independent p70 S6 kinase activation by fibroblast growth factor receptor-1 is important for proliferation but not differentiation …
  721. … Tyrosine Phosphorylation of p130Cas, Focal Adhesion kinase, and Paxillin: ROLE OF Phosphatidylinositol 3′-kinase AND FORMATION OF A …
  722. Gastrin stimulates the formation of a p60Src/p125FAK complex upstream of the Phosphatidylinositol 3–kinase signaling pathway
  723. A Phosphatidylinositol 3–kinase inhibitor induces a senescent-like growth arrest in human diploid fibroblasts
  724. A Phosphatidylinositol 3–kinase and Phosphatidylinositol transfer protein act synergistically in formation of constitutive transport vesicles from the trans-Golgi …
  725. Insulin-like growth factor (IGF)-I regulates IGF-binding protein-5 gene expression through the Phosphatidylinositol 3–kinase, protein kinase B/Akt, and p70 S6 …
  726. α-Adrenergic stimulation mediates glucose uptake through Phosphatidylinositol 3–kinase in rat heart
  727. A Phosphatidylinositol 3‐kinase inhibitor wortmannin induces radioresistant DNA synthesis and sensitizes cells to bleomycin and ionizing radiation
  728. Intracellular movement of green fluorescent protein–tagged Phosphatidylinositol 3–kinase in response to growth factor receptor signaling
  729. Activation and translocation of Rho (and ADP ribosylation factor) by insulin in rat adipocytes: apparent involvement of Phosphatidylinositol 3–kinase
  730. Intermediate affinity interleukin-2 receptor mediates survival via a Phosphatidylinositol 3–kinase-dependent pathway
  731. The Phosphatidylinositol 3–kinase inhibitor wortmannin markedly reduces chemotactic peptide-induced locomotion and increases in cytoskeletal actin in human …
  732. … pervanadate, stimulate glucose transport and GLUT translocation in muscle cells by a mechanism independent of Phosphatidylinositol 3–kinase and protein kinase C.
  733. The Phosphatidylinositol 3‐kinase inhibitor wortmannin alters the metabolism of the Alzheimer’s amyloid precursor protein
  734. … tyrosine kinase inhibits inducible nitric oxide synthase (iNOS) expression by murine peritoneal exudate macrophages: Phosphatidylinositol–3 kinase is required for …
  735. Involvement of Phosphatidylinositol 3–kinase in NFAT activation in T cells
  736. Endothelin-1 modulates insulin signaling through Phosphatidylinositol 3–kinase pathway in vascular smooth muscle cells.
  737. Phosphatidylinositol 3–kinase in HL-60 nuclei is bound to the nuclear matrix and increases during granulocytic differentiation
  738. Multiple isoforms of the regulatory subunit for Phosphatidylinositol 3–kinase (PI3–kinase) are expressed in neurons in the rat brain
  739. The CC chemokine monocyte chemotactic peptide-1 activates both the class I p85/p110 Phosphatidylinositol 3–kinase and the class II PI3K-C2α
  740. The p85 and p110 subunits of Phosphatidylinositol 3–kinase-α are substrates, in vitro, for a constitutively associated protein tyrosine kinase in platelets
  741. Phosphatidylinositol 3–kinase translocation to the nucleus is induced by interleukin 1 and prevented by mutation of interleukin 1 receptor in human osteosarcoma …
  742. The epidermal growth factor receptor associates with and recruits Phosphatidylinositol 3–kinase to the platelet-derived growth factor β receptor
  743. The Phosphatidylinositol 3′ kinase pathway is required for the survival signal of leukocyte tyrosine kinase
  744. Phosphatidylinositol 3–kinase is a requirement for insulin-like growth factor I-induced differentiation, but not for mitogenesis, in fetal brown adipocytes
  745. Stimulation of IRS-1-associated Phosphatidylinositol 3–kinase and Akt/protein kinase B but not glucose transport by β1-integrin signaling in rat adipocytes
  746. … colony-stimulating factor-activated signaling pathways in human neutrophils: involvement of Jak2 in the stimulation of Phosphatidylinositol 3–kinase
  747. CD38 ligation in human B cell progenitors triggers tyrosine phosphorylation of CD19 and association of CD19 with lyn and Phosphatidylinositol 3–kinase.
  748. MAP kinase activation by mu opioid receptor involves Phosphatidylinositol 3–kinase but not the cAMP/PKA pathway
  749. Platelet-derived growth factor-dependent cellular transformation requires either phospholipase Cγ or Phosphatidylinositol 3 kinase
  750. Sublytic C5b-9 induces proliferation of human aortic smooth muscle cells: role of mitogen activated protein kinase and Phosphatidylinositol 3–kinase
  751. … novel pathway for tumor necrosis factor-α and ceramide signaling involving sequential activation of tyrosine kinase, p21ras, and Phosphatidylinositol 3–kinase
  752. Synergistic roles of neuregulin-1 and insulin-like growth factor-I in activation of the Phosphatidylinositol 3–kinase pathway and cardiac chamber …
  753. Calmodulin is involved in membrane depolarization-mediated survival of motoneurons by Phosphatidylinositol–3 kinase-and MAPK-independent pathways
  754. p70 S6 kinase is activated by sodium arsenite in adult rat cardiomyocytes: roles for Phosphatidylinositol 3–kinase and p38 MAP kinase
  755. Phosphatidylinositol 3–kinase and Ca2+ influx dependence for ligand-stimulated internalization of the c-Kit receptor
  756. Epidermal growth factor receptor-regulated human bladder cancer motility is in part a Phosphatidylinositol 3–kinase-mediated process
  757. Involvement of Phosphatidylinositol–3 kinase in prevention of low K+-induced apoptosis of cerebellar granule neurons
  758. PTEN modulates cell cycle progression and cell survival by regulating Phosphatidylinositol 3, 4, 5,-trisphosphate and Akt/protein kinase B signaling pathway
  759. … lipopolysaccharide stimulate extracellularly regulated kinase activation in macrophages by a mechanism involving Phosphatidylinositol 3–kinase and phospholipase D …
  760. CD28 can promote T cell survival through a Phosphatidylinositol 3‐kinase‐independent mechanism
  761. SIP/SHIP inhibits Xenopus oocyte maturation induced by insulin and Phosphatidylinositol 3–kinase
  762. Insulin regulation of glucose-6-phosphate dehydrogenase gene expression is rapamycin-sensitive and requires Phosphatidylinositol 3–kinase
  763. Lysophosphatidylcholine generates superoxide anions through activation of Phosphatidylinositol 3–kinase in human neutrophils
  764. Insulin receptor substrate (IRS)-2 is dephosphorylated more rapidly than IRS-1 via its association with Phosphatidylinositol 3–kinase in skeletal muscle cells
  765. The survival of sympathetic neurons promoted by potassium depolarization, but not by cyclic AMP, requires Phosphatidylinositol 3‐kinase and Akt
  766. Nuclear translocation of PKCζ during ischemia and its inhibition by wortmannin, an inhibitor of Phosphatidylinositol 3–kinase
  767. CD7-mediated regulation of integrin adhesiveness on human T cells involves tyrosine phosphorylation-dependent activation of Phosphatidylinositol 3–kinase.
  768. LCK-phosphorylated human killer cell-inhibitory receptors recruit and activate Phosphatidylinositol 3–kinase
  769. 14-3–3β protein associates with insulin receptor substrate 1 and decreases insulin-stimulated Phosphatidylinositol 3′-kinase activity in 3T3L1 adipocytes
  770. Evidence that Phosphatidylinositol 3–kinase and p70S6K protein are involved in differentiation of HL-60 cells induced by calcitriol.
  771. Inhibition of Phosphatidylinositol 3‐kinase activity blocks cellular differentiation mediated by glial cell line‐derived neurotrophic factor in dopaminergic neurons
  772. Roles of Phosphatidylinositol 3–kinase and Rac in the nuclear signaling by tumor necrosis factor-α in rat-2 fibroblasts
  773. Inositol hexaphosphate inhibits cell transformation and activator protein 1 activation by targeting Phosphatidylinositol–3′ kinase
  774. The role of Phosphatidylinositol 3–kinase, Src kinase, and protein kinase A signaling pathways in insulin and glucagon regulation of CYP2E1 expression
  775. Mitogen-activated protein kinase and Phosphatidylinositol 3–kinase pathways are not sufficient for insulin-like growth factor I-induced mitogenesis and tumorigenesis
  776. Fc receptor-mediated platelet activation is dependent on Phosphatidylinositol 3–kinase activation and involves p120cbl
  777. Variant in the regulatory subunit of Phosphatidylinositol 3–kinase (p85alpha): preliminary evidence indicates a potential role of this variant in the acute insulin …
  778. … 3–kinase/p70 ribosomal S6 protein kinase pathway is required for the regulation by insulin of the p85α regulatory subunit of Phosphatidylinositol 3–kinase …
  779. The involvement of Phosphatidylinositol 3–kinase in crystal induced human neutrophil activation.
  780. Wortmannin inhibits the growth of mammary tumors despite the existence of a novel wortmannin-insensitive Phosphatidylinositol–3–kinase
  781. … receptors gives rise to the selective modulation of intracellular signaling in B cells: regulation of the association of Phosphatidylinositol 3–kinase and inositol 5 …
  782. Phosphatidylinositol 3′-kinase and tyrosine-phosphatase activation positively modulate Convulxin-induced platelet activation. Comparison with collagen
  783. Phosphorylation of cbl after Stimulation of Nb2 Cells with Prolactin and Its Association with Phosphatidylinositol 3–kinase
  784. Phosphatidylinositol 3–kinase translocates onto liver endoplasmic reticulum and may account for the inhibition of glucose-6-phosphatase during refeeding
  785. Regulation of endocytic-transcytotic pathways and bile secretion by Phosphatidylinositol 3–kinase in rats
  786. Cripto-1 induces Phosphatidylinositol 3′-kinase-dependent phosphorylation of AKT and glycogen synthase kinase 3β in human cervical carcinoma cells
  787. Epidermal growth factor stimulation of Phosphatidylinositol 3–kinase during wound closure in rabbit corneal epithelial cells.
  788. … induces the tyrosine phosphorylation of insulin receptor substrate-2: an alternate pathway for erythropoietin-induced Phosphatidylinositol 3–kinase activation
  789. Localization of a class II Phosphatidylinositol 3–kinase, PI3KC2α, to clathrin-coated vesicles
  790. Role of the vav proto-oncogene product (Vav) in erythropoietin-mediated cell proliferation and Phosphatidylinositol 3–kinase activity
  791. Possible involvement of Phosphatidylinositol 3‐kinase in regulated exocytosis: studies in chromaffin cells with inhibitor LY294002
  792. Src-family Tyrosine kinases in Activation of ERK-1 and p85/p110-Phosphatidylinositol 3–kinase by G/CCKBReceptors
  793. Signaling through the EBV/C3d receptor (CR2, CD21) in human B lymphocytes: activation of Phosphatidylinositol 3–kinase via a CD19-independent pathway
  794. Cloning of human p55γ, a regulatory subunit of Phosphatidylinositol 3–kinase, by a yeast two-hybrid library screen with the insulin-like growth factor-I receptor
  795. Angiotensin II induces activation of Phosphatidylinositol 3–kinase in cardiomyocytes
  796. Involvement of Phosphatidylinositol 3′‐kinase in stem‐cell‐factor‐induced phospholipase D activation and arachidonic acid release
  797. CD45-induced tumor necrosis factor α production in monocytes is Phosphatidylinositol 3–kinase-dependent and nuclear factor-κB-independent
  798. Wortmannin, a Phosphatidylinositol 3–kinase inhibitor, blocks antigen-mediated, but not CD3 monoclonal antibody-induced, activation of murine CD4+ T cells.
  799. Phosphatidylinositol 3–kinase is required for CD28 but not CD3 regulation of the TEC family tyrosine kinase EMT/ITK/TSK: functional and physical interaction of EMT …
  800. Endothelin-1-induced GLUT4 translocation is mediated via Gαq/11 protein and Phosphatidylinositol 3–kinase in 3T3-L1 adipocytes
  801. N-Methyl-D-aspartate inhibits apoptosis through activation of Phosphatidylinositol 3–kinase in cerebellar granule neurons: a role for insulin receptor substrate …
  802. Phosphatidylinositol 3‐kinase binds to profilin through the p85α subunit and regulates cytoskeletal assembly
  803. HMG-CoA reductase inhibitor-induced L6 myoblast cell death: involvement of the Phosphatidylinositol 3–kinase pathway
  804. Requirement for Ras and Phosphatidylinositol 3–kinase signaling uncouples the glucocorticoid-induced junctional organization and transepithelial electrical …
  805. Cell Interactions with Collagen Matrices In Vivo and In Vitro Depend on Phosphatidylinositol 3–kinase and Free Cytoplasmic Calcium
  806. Affinity modulation of very late antigen-5 through Phosphatidylinositol 3–kinase in mast cells
  807. Tyrosine phosphorylation of the CD3-ε subunit of the T cell antigen receptor mediates enhanced association with Phosphatidylinositol 3–kinase in Jurkat T …
  808. Platelet-derived growth factor inhibits insulin stimulation of insulin receptor substrate-1-associated Phosphatidylinositol 3–kinase in 3T3-L1 adipocytes without …
  809. … choline phosphate-induced mitogenesis in fibroblasts involves activation of pp70 S6 kinase and Phosphatidylinositol 3′-kinase through an extracellular site …
  810. Functional cooperation of the interleukin-2 receptor β chain and Jak1 in Phosphatidylinositol 3–kinase recruitment and phosphorylation
  811. … Factor–Activated Signaling Pathways in Human Neutrophils. I. Tyrosine Phosphorylation-Dependent Stimulation of Phosphatidylinositol 3–kinase and Inhibition by …
  812. Insulin receptor substrate-1 and Phosphatidylinositol 3–kinase regulate extracellular signal-regulated kinase-dependent and-independent signaling pathways during …
  813. Binding of receptor-recognized forms of α2-macroglobulin to the α2-macroglobulin signaling receptor activates Phosphatidylinositol 3–kinase
  814. … HT-29 cells is independent of nitric oxide formation: evidence for an interleukin-13-driven Phosphatidylinositol 3–kinase-dependent survival mechanism
  815. Involvement of protein tyrosine kinase p72syk and Phosphatidylinositol 3–kinase in CD2-mediated granular exocytosis in the natural killer cell line, NK3. 3.
  816. Expression of Phosphatidylinositol 3–kinase during EGF-Stimulated Wound Repair in Rabbit Corneal Epithelium
  817. Insulin-like growth factor-1 stimulates rat prolactin gene expression by a Ras, ETS and Phosphatidylinositol 3–kinase dependent mechanism
  818. SHP-1 associates with both platelet-derived growth factor receptor and the p85 subunit of Phosphatidylinositol 3–kinase
  819. CD72‐mediated B cell activation involves recruitment of CD19 and activation of Phosphatidylinositol 3‐kinase
  820. Action of insulin on the surface morphology of hepatocytes: role of Phosphatidylinositol 3–kinase in insulin-induced shape change of microvilli
  821. Biphasic activation of p21ras by endothelin-1 sequentially activates the ERK cascade and Phosphatidylinositol 3–kinase
  822. … factor of src-and hepatocyte growth factor-dependent invasiveness of intestinal and kidney epithelial cells: Phosphatidylinositol 3′-kinase is a critical …
  823. Identification and chromosome assignment of a human gene encoding a novel Phosphatidylinositol–3 kinase
  824. Phosphatidylinositol 3′-kinase, but not S6-kinase, is required for insulin-like growth factor-I and IL-4 to maintain expression of Bcl-2 and promote survival of myeloid …
  825. Epidermal growth factor and insulin-induced deoxyribonucleic acid synthesis in primary rat hepatocytes is Phosphatidylinositol 3–kinase dependent and dissociated …
  826. … (p125FAK) and paxillin in rat pancreatic acini by a phospholipase C-independent process that depends on Phosphatidylinositol 3–kinase, the small GTP …
  827. Effects of Phosphatidylinositol–3–kinase inhibitors on degranulation and gene induction in allergically triggered mouse mast cells
  828. Activation of Phosphatidylinositol 3‘-kinase by insulin-like growth factor-I rescues promyeloid cells from apoptosis and permits their differentiation into granulocytes.
  829. Epidermal growth factor stimulates phospholipase D independent of phospholipase C, protein kinase C or Phosphatidylinositol–3 kinase activation in immortalized …
  830. … diphosphotyrosine-containing peptide that mimics activated platelet-derived growth factor receptor β induces oligomerization of Phosphatidylinositol 3–kinase
  831. Monocytic differentiation of HL-60 cells is characterized by the nuclear translocation of Phosphatidylinositol 3–kinase and of definite Phosphatidylinositol-specific …
  832. Thapsigargin-induced secretion is dependent on activation of a cholera toxin-sensitive and Phosphatidylinositol–3–kinase-regulated phospholipase D in a mast cell …
  833. Changes in the mitogen-activated protein kinase and Phosphatidylinositol 3–kinase/Akt signaling associated with the induction of apoptosis.
  834. IL-2 signaling controls actin organization through Rho-like protein family, Phosphatidylinositol 3–kinase, and protein kinase C-zeta.
  835. A role for Phosphatidylinositol 3–kinase in platelet aggregation in response to low, but not high, concentrations of PAF or thrombin
  836. Differential association of Phosphatidylinositol 3–kinase with insulin receptor substrate (IRS)-1 and IRS-2 in human thymocytes in response to IL-7.
  837. Effect of wortmannin, an inhibitor of Phosphatidylinositol 3–kinase, on the first mitotic divisions of the fertilized sea urchin egg
  838. Platelet‐Derived Growth Factor Stimulates Sodium‐Dependent Pi Transport in Osteoblastic Cells via Phospholipase Cγ and Phosphatidylinositol 3′‐kinase
  839. Inhibition of human cardiac fibroblast mitogenesis by blockade of mitogen‐activated protein kinase and Phosphatidylinositol 3‐kinase
  840. Phosphatidylinositol 3–kinase and dynamics of insulin resistance in denervated slow and fast muscles in vivo
  841. Phosphatidylinositol 4-kinase, but not Phosphatidylinositol 3–kinase, is present in GLUT4-containing vesicles isolated from rat skeletal muscle
  842. Raf-1 kinase Activation by Angiotensin II in Adrenal Glomerulosa Cells: Roles of Gi, Phosphatidylinositol 3–kinase, and Ca2+ Influx
  843. The inositol polyphosphate 4-phosphatase forms a complex with Phosphatidylinositol 3–kinase in human platelet cytosol
  844. … chemokinesis in normal human neutrophils is dependent on D‐glucose concentration and sensitive to inhibitors of tyrosine kinase and Phosphatidylinositol 3‐kinase
  845. Brain‐derived neurotrophic factor stimulates interactions of Shp2 with Phosphatidylinositol 3‐kinase and Grb2 in cultured cerebral cortical neurons
  846. Phosphatidylinositol 3–kinase and focal adhesion kinase are early signals in the growth factor–like responses to thrombospondin-1 seen in human vascular smooth …
  847. Insulin stimulation of K+ uptake in 3T3-L1 fibroblasts involves Phosphatidylinositol 3–kinase and protein kinase C-zeta
  848. Phosphatidylinositol 3′-kinase and p70s6k are required for insulin but not bisperoxovanadium 1, 10-phenanthroline (bpV (phen)) inhibition of insulin-like …
  849. … secretagogues activate protein tyrosine phosphorylation and release of arachidonic acid in mast cells via a novel protein kinase C and Phosphatidylinositol 3‐kinase …
  850. Possible role for Phosphatidylinositol 3–kinase in regulating meiotic maturation of bovine oocytes in vitro
  851. Insulin receptor substrate (IRS)-1 and IRS-2 are tyrosine-phosphorylated and associated with Phosphatidylinositol 3–kinase in response to brain-derived …
  852. … C-γ1 renders platelet-derived growth factor β-receptor-expressing cells independent of the Phosphatidylinositol 3–kinase pathway for chemotaxis
  853. Activation of Phosphatidylinositol 3–kinase is necessary for differentiation of FDC-P1 cells following stimulation of type III receptor tyrosine kinases
  854. Potentiation of Insulin-Induced Phosphatidylinositol–3 kinase Activity by Phorbol Ester Is Mediated by Protein kinase Cϵ
  855. Phosphatidylinositol 3–kinase and protein kinase C are required for the inhibition of caspase activity by epidermal growth factor
  856. Signalling-competent truncated forms of ErbB2 in breast cancer cells: differential regulation by protein kinase C and Phosphatidylinositol 3–kinase
  857. Involvement of both the tyrosine kinase and the Phosphatidylinositol–3′ kinase signal transduction pathways in the regulation of lipoprotein lipase expression in J774 …
  858. Role of Phosphatidylinositol 3–kinase in degranulation induced by IgE-dependent and-independent mechanisms in rat basophilic RBL-2H3 (ml) cells
  859. PDGF-induced glycosaminoglycan synthesis is mediated via Phosphatidylinositol 3–kinase
  860. … new tyrosine-phosphorylated 97-kDa adaptor protein mediates interleukin-2-induced association of SHP-2 with p85-Phosphatidylinositol 3–kinase in human T …
  861. Phosphatidylinositol 3–kinase mediates heregulin-induced growth inhibition in human epithelial cells.
  862. Insulin activation of Phosphatidylinositol 3–kinase in human skeletal muscle in vivo
  863. … is tyrosine-phosphorylated by interleukin-4 and enhances mitogenic and survival signals of interleukin-4 receptor by linking with the Phosphatidylinositol 3′-kinase …
  864. Phosphatidylinositol 3–kinase inhibitors block aortic smooth muscle cell proliferation in mid-late G1 phase: effect on cyclin-dependent kinase 2 and the inhibitory …
  865. The Phosphatidylinositol 3–kinase inhibitor wortmannin sensitizes quiescent but not proliferating MG-63 human osteosarcoma cells to radiation
  866. Contrasting Signaling Pathways of α1A- and α1B-Adrenergic Receptor Subtype Activation of Phosphatidylinositol 3–kinase and Ras in Transfected NIH3T3 Cells
  867. Granulocyte-macrophage colony-stimulating factor and IL-5 activate mitogen-activated protein kinase through Jak2 kinase and Phosphatidylinositol 3–kinase inhuman …
  868. Inositide signalling in Chlamydomonas: characterization of a Phosphatidylinositol 3–kinase gene
  869. Suppression of insulin-stimulated Phosphatidylinositol 3–kinase activity by the β3-adrenoceptor agonist CL316243 in rat adipocytes
  870. Characterization of a novel tyrosine phosphorylated 100-kDa protein that binds to SHP-2 and Phosphatidylinositol 3′-kinase in myeloid cells
  871. Differential regulation of insulin receptor substrate-2 and mitogen-activated protein kinase tyrosine phosphorylation by Phosphatidylinositol 3–kinase inhibitors in SH …
  872. … and protein kinase C in dibutyryl cAMP-differentiated U937 cells is dependent solely on the tyrosine-kinase activated form of Phosphatidylinositol–3–kinase
  873. … to membrane expansion during growth of cultured embryonic mouse hippocampal neurons: sensitivity to inhibitors of Phosphatidylinositol 3–kinase and other protein …
  874. LY294002-mediated inhibition of Phosphatidylinositol 3–kinase activity triggers growth inhibition and apoptosis in CD40-triggered Ramos–Burkitt lymphoma B cells
  875. Oncogenic Ras-induced germinal vesicle breakdown is independent of Phosphatidylinositol 3–kinase in Xenopus oocytes
  876. The structural requirement of Phosphatidylinositols as substrate of Phosphatidylinositol 3–kinase
  877. Phosphatidylinositol 3–kinase regulates differentiation of H9c2 cardiomyoblasts mainly through the protein kinase B/Akt-independent pathway
  878. H-ras induces glucose uptake in brown adipocytes in an insulin-and Phosphatidylinositol 3–kinase-independent manner
  879. Interaction of Wild Type and Dominant-Negative p55PIK Regulatory Subunit of Phosphatidylinositol 3–kinase with Insulin-Like Growth Factor-1 Signaling Proteins
  880. Activation of S6 kinase in human neutrophils by calcium pyrophosphate dihydrate crystals: protein kinase C-dependent and Phosphatidylinositol–3–kinase …
  881. EGF activates ErbB-2 and stimulates Phosphatidylinositol 3–kinase in human airway smooth muscle cells
  882. CD16‐mediated activation of Phosphatidylinositol‐3 kinase (Pl‐3K) in human NK cells involves tyrosine phosphorylation of Cbl and its association with Grb2, Shc …
  883. Retinoic acid inhibits transformation by preventing Phosphatidylinositol 3–kinase dependent activation of the c-fos promoter
  884. Binding of HIV-1 to its receptor induces tyrosine phosphorylation of several CD4-associated proteins, including the Phosphatidylinositol 3–kinase
  885. … of bradykinin in the human colon carcinoma cell line SW-480 involves sequential activation of a Gq/11 protein, Phosphatidylinositol 3–kinase β, and protein …
  886. Insulin signalling in heart involves insulin receptor substrates-1 and-2, activation of Phosphatidylinositol 3–kinase and the JAK 2-growth related pathway
  887. Wortmannin blocks goldfish retinal Phosphatidylinositol 3–kinase and neurite outgrowth
  888. … transcription: involvement of the ligand-binding domain of the glucocorticoid receptor and independence from the Phosphatidylinositol 3–kinase and mitogen-activated …
  889. Binding of CD4 ligands induces tyrosine phosphorylation of Phosphatidylinositol–3 kinase p110 subunit.
  890. Involvement of Phosphatidylinositol 3–kinase and mitogen-activated protein kinase pathways in AII-mediated enhanced expression of Gi proteins in vascular smooth …
  891. … -1–induced cell-cycle progression: involvement of extracellular signal-regulated kinase, protein kinase C, and Phosphatidylinositol 3–kinase at distinct points
  892. Phosphatidylinositol 3–kinase in myogenesis
  893. Involvement of Phosphatidylinositol 3–kinase in the mediation of erythropoietin-induced activation of p70S6k
  894. Liver microsomal glucose-6-phosphatase is competitively inhibited by the lipid products of Phosphatidylinositol 3–kinase
  895. Interleukin-3 induces association of the protein-tyrosine phosphatase SHP2 and Phosphatidylinositol 3–kinase with a 100-kDa tyrosine-phosphorylated …
  896. Structural and biochemical evaluation of the interaction of the Phosphatidylinositol 3–kinase p85α Src homology 2 domains with phosphoinositides and …
  897. Phosphatidylinositol 3–kinase is required for the induction of ornithine decarboxylase in leukemia cells stimulated to growth
  898. Corneal epithelial wound healing increases the expression but not long lasting activation of the p85a subunit of Phosphatidylinositol–3 kinase
  899. Wortmannin, a Phosphatidylinositol 3–kinase inhibitor, blocks the assembly of peptide-MHC class II complexes.
  900. Design of peptidomimetics that inhibit the association of Phosphatidylinositol 3–kinase with platelet-derived growth factor-β receptor and possess cellular activity
  901. Monocyte adherence induced by lipopolysaccharide involves CD14, LFA-1, and cytohesin-1: regulation by Rho and Phosphatidylinositol 3–kinase
  902. Inhibition of MG‐63 cell proliferation and PDGF‐stimulated cellular processes by inhibitors of Phosphatidylinositol 3‐kinase
  903. Phosphorylation of Cbl following stimulation with interleukin-3 and its association with Grb2, Fyn, and Phosphatidylinositol 3–kinase
  904. JNK/SAPK activation by platelet-derived growth factor in A431 cells requires both the phospholipase C-γ and the Phosphatidylinositol 3–kinase signaling pathways of …
  905. Evidence for Phosphatidylinositol 3–kinase-dependent T cell antigen receptor (TCR) signal transduction
  906. Effects of Phosphatidylinositol 3–kinase inhibitors, wortmannin and LY294002, on germinal vesicle breakdown (GVBD) in porcine oocytes
  907. Phosphatidylinositol 3–kinase is not required for recycling of mannose 6-phosphate receptors from late endosomes to the trans-Golgi network.
  908. Islet transplantation restores normal levels of insulin receptor and substrate tyrosine phosphorylation and Phosphatidylinositol 3–kinase activity in skeletal muscle and …
  909. Cripto-1 inhibits beta-casein expression in mammary epithelial cells through a p21ras-and Phosphatidylinositol 3‘-kinase-dependent pathway.
  910. An Insulin-like Growth Factor-mediated, Phosphatidylinositol 3′ kinase-independent Survival Signaling Pathway in β Tumor Cells
  911. … a patient with severe insulin resistance: association of defective insulin-stimulated glucose transport with impaired Phosphatidylinositol 3–kinase activity in fibroblasts
  912. Hydrogen peroxide-induced activation of SAPK/JNK regulated by Phosphatidylinositol 3–kinase in Chinese hamster V79 cells
  913. Synergistic role of the Phosphatidylinositol 3–kinase and mitogen-activated protein kinase cascade in the regulation of insulin receptor trafficking
  914. Evidence that thrombin-stimulated DNA synthesis in pulmonary arterial fibroblasts involves Phosphatidylinositol 3–kinase-dependent p70 ribosomal S6 kinase …
  915. Phosphatidylinositol 3′-kinase associates with an insulin receptor substrate-1 serine kinase distinct from its intrinsic serine kinase
  916. Possibility of Distinct Insulin-Signaling Pathways Beyond Phosphatidylinositol 3–kinase–Mediating Glucose Transport and Lipogenesis
  917. Insulin‐stimulated cell growth in insulin receptor substrate‐1–deficient ZR‐75‐1 cells is mediated by a Phosphatidylinositol‐3‐kinase–independent pathway
  918. Down regulation of the expression of the p110, p85 and p55 subunits of Phosphatidylinositol 3–kinase during colon cancer cell anchorage-independent growth.
  919. c-Src and Phosphatidylinositol 3–kinase are involved in NGF-dependent tyrosine phosphorylation of Shc in PC12 cells
  920. Is stimulation of class-1 Phosphatidylinositol 3–kinase activity by insulin sufficient to activate pathways involved in glucose metabolism.
  921. Phenylarsine oxide inhibits insulin activation of Phosphatidylinositol 3′-kinase
  922. Interaction of insulin receptor substrate-1 (IRS-1) with Phosphatidylinositol 3–kinase: effect of substitution of serine for alanine in potential IRS-1 serine phosphorylation …
  923. Phosphorylation of the Grb2-and Phosphatidylinositol 3–kinase p85–binding p36/38 by Syk in Lck-Negative T Cells
  924. Tyrosine phosphorylation of Phosphatidylinositol 3–kinase and of the thromboxane A2 (TXA2) receptor by the TXA2 mimetic I-BOP in A7r5 cells
  925. … in neonatal rat ventricular myocytes by Ras is mediated by Ral guanine nucleotide dissociation stimulator (Ral. GDS) and Phosphatidylinositol 3–kinase in addition to …
  926. Effect of Ethanol on Intracellular Vesicular Transport from Golgi to the Apical Cell Membrane: Role of Phosphatidylinositol 3‐kinase and Phospholipase A2 in Golgi …
  927. Evidence that a kinase distinct from protein kinase C and Phosphatidylinositol 3–kinase mediates ligation-dependent serine/threonine phosphorylation of the T …
  928. Interleukin-4 (IL-4) induces Phosphatidylinositol 3–kinase (p85) dephosphorylation: implications for the role of SHP-1 in the IL-4-induced signals in human B …
  929. Inhibition of Kit expression by IL-4 and IL-10 in murine mast cells: role of STAT6 and Phosphatidylinositol 3′-kinase
  930. Phosphatidylinositol 3–kinase is required for the regulation of hepatitis B surface antigen production and mitogen-activated protein kinase activation by insulin but not …
  931. Formation of distinct signalling complexes involving Phosphatidylinositol 3‐kinase activity with stimulation of epidermal growth factor or insulin‐like growth factor‐I in …
  932. Secretory IgA-mediated basophil activation: II. Roles of GTP-binding regulatory proteins and Phosphatidylinositol 3–kinase
  933. Identification of protein kinase B (PKB) as a Phosphatidylinositol 3, 4, 5-trisphosphate binding protein in Dictyostelium discoideum
  934. Density dependent elevation of Phosphatidylinositol–3 kinase level in rat 3Y1 cells
  935. CD40-triggered protein tyrosine phosphorylation on Vav and on Phosphatidylinositol 3–kinase correlates with survival of the Ramos–Burkitt lymphoma B cell line
  936. Phosphatidylinositol 3–kinase translocation to the nucleus is an early event in the interleukin-1 signalling mechanism in human osteosarcoma Saos-2 cells.
  937. … and insensitive intracellular signalling pathways in undifferentiated 3T3‐L1 cells stimulated by insulin converge with Phosphatidylinositol 3‐kinase upstream of the …
  938. Phosphatidylinositol 3′-kinase is associated with a serine kinase that is activated by okadaic acid
  939. Phosphatidylinositol 3–kinase in Cumulus Cells is Responsible for Meiotic Progression from MI to M II Stage in Porcine Follicular Oocytes
  940. IL-2, but not IL-4 and other cytokines, induces phosphorylation of a 98-kDa protein associated with SHP-2, Phosphatidylinositol 3′-kinase, and Grb2
  941. … Nucleotide Exchange Factor and Ha-Ras: EVIDENCES FOR A FUNCTION OF Raf-1 AND Phosphatidylinositol 3–kinase UPSTREAM TO Ras
  942. … in tyrosine phosphorylation of insulin receptor and insulin receptor substrate-1 (IRS-1) and association of p85 subunit of Phosphatidylinositol 3–kinase with IRS-1 after …
  943. Polymorphism and CH… O interaction of wortmannin, a Phosphatidylinositol 3–kinase inhibitor
  944. … stimulation lowers the activation threshold and enhances the alloreactivity of cord blood T cells by activating the Phosphatidylinositol 3–kinase pathway and inducing …
  945. … ) and activating protein 1 (AP-1) by oncogenic 70Z Cbl requires an intact phosphotyrosine binding domain but not Crk (L) or p85 Phosphatidylinositol 3–kinase …
  946. Role of Phosphatidylinositol 3–kinase in platelet aggregation
  947. Down‐regulation of LFA‐1‐mediated T cell adhesion induced by the HIV envelope glycoprotein gp160 requires Phosphatidylinositol‐3‐kinase activity
  948. Phosphatidylinositol-4-phosphate 5-kinase isozymes catalyze the synthesis of 3-phosphate-containing Phosphatidylinositol signaling molecules
  949. … -(Hexadecyloxy)-3 (5)-Methoxybutanephosphonate (C4-PI), Inhibits Epithelial Cell Proliferation and is a Substrate but not an Inhibitor of Phosphatidylinositol 3–kinase
  950. Up-regulation of Phosphatidylinositol 3–kinase in psoriatic lesions
  951. … of connexin-43, gap junctional protein, in cumulus cells is regulated by mitogen-activated protein kinase and Phosphatidylinositol 3–kinase during in vitro meiotic …
  952. Inhibition of Phosphatidylinositol 3–kinase
  953. 1 , 25-Dihydroxyvitamin D 3–induced Myeloid Cell Differentiation Is Regulated by a Vitamin D Receptor–Phosphatidylinositol 3–kinase Signaling Complex
  954. Immunocytochemical detection of Phosphatidylinositol 3 kinase in Burkitt lymphoma cells
  955. Defect in long-term activation of Phosphatidylinositol 3–kinase by insulin in vivo: studies in insulin-resistant hHTg rats
  956. Hexamethylenebisacetamide modulation of thyroglobulin and protein levels in thyroid cells is not mediated by Phosphatidylinositol–3–kinase: A study with wortmannin
  957. The regulation and function of Phosphatidylinositol 3–kinase
  958. A role for Phosphatidylinositol 3–kinase in platelet aggregation
  959. Activation of the Phosphatidylinositol 3–kinase Serine kinase by 1FN-a’
  960. Phosphatidylinositol 3–kinase mediates interleukin-l-induced activation of NFB and AP-1 Shrikanth
  961. Regulation of the p85/p110 Phosphatidylinositol 3–kinase
  962. Through Phosphatidylinositol 3–kinase in Rat Heart
  963. Cloning and characterisation of novel isoforms of Phosphatidylinositol 3–kinase
  964. REGULATION OF CHOLANGIOCYTE CL SECRETION BY Phosphatidylinositol 3–kinase
  965. Bidirectional Effect of Regulatory Subunits of Phosphatidylinositol 3–kinase Dependent Signalling Pathway
  966. Role of Phosphatidylinositol 3–kinase as an effector of Ras
  967. Mechanism of radiation sensitization by wortmannin, a Phosphatidylinositol–3 kinase inhibitor
  968. Up-regulation of Phosphatidylinositol 3–kinase in psoriatic lesions
  969. Activation of Phosphatidylinositol 3–kinase via epidermal growth factor receptor in isolated rat hepatocytes
  970. Studies of a Phosphatidylinositol 3–kinase complex linked to vesicular trafficking in human cells
  971. Comparison of insulin and platelet-derived growth factor signaling: focusing on Phosphatidylinositol 3–kinase
  972. Activation of p70S6K and ERK as well as Akt by Heat Shock and Hyperosmorality Stress is Phosphatidylinositol 3–kinase Dependent
  973. Inhibition of proliferation by wortmannin through the blokade of Phosphatidylinositol 3–kinase in mast cell line P815
  974. Antagonists of Phosphatidylinositol 3–kinase block phosphorylation-dependent activation of the leukocyte NADPH oxidase in a cell-free system
  975. Phosphatidylinositol 3–kinase AND cAMP INVOLVEMENT IN THE GROWTH HORMONE REGULATION OF ION TRANSPORT IN CACO-2 CELLS
  976. Serendipitous studies in cell signaling: The role of Phosphatidylinositol 3–kinase (PI3K) in signal transduction, identification of new PI3K targets, and the …
  977. Activation of Phosphatidylinositol 3–kinase by interleukin-13 in colonic epithelial cells: regulation of nitric oxide and apoptosis
  978. Phosphatidylinositol–3 kinase dependent pathways: the role in control of cell growth, survival, and malignant transformation.
  979. Beclin–Phosphatidylinositol 3–kinase complex functions at the trans-Golgi network
  980. Phosphatidylinositol 3–kinase signaling controls levels of hypoxia-inducible factor
  981. New role for Shc in activation of the Phosphatidylinositol 3–kinase/Akt pathway
  982. Regulation of B-cell activation and differentiation by the Phosphatidylinositol 3–kinase and phospholipase Cgamma pathway.
  983. Phosphatidylinositol 3–kinase/AKT-mediated activation of estrogen receptor α: a new model for anti-estrogen resistance
  984. Phosphatidylinositol 3–kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endothelial cells
  985. Tyrosine phosphorylation of p85 relieves its inhibitory activity on Phosphatidylinositol 3–kinase
  986. A Phosphatidylinositol 3–kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus
  987. The Phosphatidylinositol 3′-kinase p85α gene is an oncogene in human ovarian and colon tumors
  988. Two Distinct Vps34 Phosphatidylinositol 3–kinase Complexes Function in Autophagy and Carboxypeptidase Y Sorting inSaccharomyces cerevisiae
  989. Regulation of neutrophil apoptosis: a role for protein kinase C and Phosphatidylinositol–3–kinase
  990. Ischemic preconditioning activates Phosphatidylinositol–3–kinase upstream of protein kinase C
  991. Role of Phosphatidylinositol 3–kinase-Akt pathway in nucleophosmin/anaplastic lymphoma kinase-mediated lymphomagenesis
  992. Phosphatidylinositol 3–kinase signaling inhibits DAF-16 DNA binding and function via 14-3–3-dependent and 14-3–3-independent pathways
  993. Phosphatidylinositol 3–kinase-dependent activation of trypsinogen modulates the severity of acute pancreatitis
  994. Phosphatidylinositol 3‐kinase mediates neuroprotection by estrogen in cultured cortical neurons
  995. Anti-apoptotic signaling by hepatocyte growth factor/Met via the Phosphatidylinositol 3–kinase/Akt and mitogen-activated protein kinase pathways
  996. Phosphatidylinositol 3–kinase regulates Raf1 through Pak phosphorylation of serine 338
  997. Transforming ability of MEN2A-RET requires activation of the Phosphatidylinositol 3–kinase/AKT signaling pathway
  998. Phosphatidylinositol 3–kinase as a mediator of TNF-induced NF-κB activation
  999. Expression of constitutively active Phosphatidylinositol 3–kinase inhibits activation of caspase 3 and apoptosis of cardiac muscle cells
  1000. In Vivo and in Vitro Ovarian Carcinoma Growth Inhibition by a Phosphatidylinositol 3–kinase Inhibitor (LY294002)
  1001. Opposing actions of Phosphatidylinositol 3‐kinase and glycogen synthase kinase‐3β in the regulation of HSF‐1 activity
  1002. Phosphatidylinositol 3–kinase function is required for transforming growth factor β-mediated epithelial to mesenchymal transition and cell migration
  1003. Substrate specificity of αvβ3integrin-mediated cell migration and Phosphatidylinositol 3–kinase/AKT pathway activation
  1004. Role of reactive oxygen species and Phosphatidylinositol 3–kinase in cardiomyocyte differentiation of embryonic stem cells
  1005. Phosphatidylinositol 3–kinase/Akt activity regulates c-FLIP expression in tumor cells
  1006. The tumor suppressor PTEN positively regulates macroautophagy by inhibiting the Phosphatidylinositol 3–kinase/protein kinase B pathway
  1007. The Phosphatidylinositol 3–kinase/AKT kinase pathway in multiple myeloma plasma cells: roles in cytokine-dependent survival and proliferative responses
  1008. Myotubularin, a phosphatase deficient in myotubular myopathy, acts on Phosphatidylinositol 3–kinase and Phosphatidylinositol 3-phosphate pathway
  1009. Insulin-like growth factor-mediated muscle differentiation: collaboration between Phosphatidylinositol 3–kinase-Akt-signaling pathways and myogenin
  1010. The β2-Adrenergic Receptor Delivers an Antiapoptotic Signal to Cardiac Myocytes Through Gi-Dependent Coupling to Phosphatidylinositol 3′-kinase
  1011. Phosphatidylinositol 3–kinase activity in epidermal growth factor-stimulated matrix metalloproteinase-9 production and cell surface association
  1012. The osteopontin-CD44 survival signal involves activation of the Phosphatidylinositol 3–kinase/Akt signaling pathway
  1013. Latent membrane protein 2A-mediated effects on the Phosphatidylinositol 3–kinase/Akt pathway
  1014. The p75 neurotrophin receptor activates Akt (protein kinase B) through a Phosphatidylinositol 3–kinase-dependent pathway
  1015. Pancreatic cancer cell proliferation is Phosphatidylinositol 3–kinase dependent
  1016. Lipoarabinomannan from Mycobacterium tuberculosis promotes macrophage survival by phosphorylating Bad through a Phosphatidylinositol 3–kinase/Akt …
  1017. Kit/stem cell factor receptor-induced activation of Phosphatidylinositol 3′-kinase is essential for male fertility
  1018. Hypoxia activates a platelet-derived growth factor receptor/Phosphatidylinositol 3–kinase/Akt pathway that results in glycogen synthase kinase–3 inactivation
  1019. Insulin rescues retinal neurons from apoptosis by a Phosphatidylinositol 3–kinase/Akt-mediated mechanism that reduces the activation of caspase-3
  1020. Regulation of the protein kinase Raf-1 by oncogenic Ras through Phosphatidylinositol 3–kinase, Cdc42/Rac and Pak
  1021. BCR/ABL regulates expression of the cyclin-dependent kinase inhibitor p27Kip1 through the Phosphatidylinositol 3–kinase/AKT pathway
  1022. A novel role for Phosphatidylinositol 3–kinase β in signaling from G protein-coupled receptors to Akt
  1023. Platelet-derived growth factor-induced H2O2 production requires the activation of Phosphatidylinositol 3–kinase
  1024. Modulation of hypoxia-inducible factor 1α expression by the epidermal growth factor/Phosphatidylinositol 3–kinase/PTEN/AKT/FRAP pathway in human prostate …
  1025. Regulation of melanogenesis through Phosphatidylinositol 3–kinase-Akt pathway in human G361 melanoma cells
  1026. Hypoxia induces the activation of the Phosphatidylinositol 3–kinase/Akt cell survival pathway in PC12 cells: protective role in apoptosis
  1027. Cytokines promote motoneuron survival through the Janus kinase-dependent activation of the Phosphatidylinositol 3–kinase pathway
  1028. Nucleophosmin–anaplastic lymphoma kinase associated with anaplastic large-cell lymphoma activates the Phosphatidylinositol 3–kinase/Akt antiapoptotic signaling …
  1029. A Phosphatidylinositol 3–kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor …
  1030. Phosphatidylinositol 3 kinase contributes to the transformation of hematopoietic cells by the D816V c-Kit mutant
  1031. α7 nicotinic receptor transduces signals to Phosphatidylinositol 3–kinase to block A β-amyloid-induced neurotoxicity
  1032. The bile acid taurochenodeoxycholate activates a Phosphatidylinositol 3–kinase-dependent survival signaling cascade
  1033. The hepatitis B virus-X protein activates a Phosphatidylinositol 3–kinase-dependent survival signaling cascade
  1034. Phosphorylation of PDE3B by Phosphatidylinositol 3–kinase associated with the insulin receptor
  1035. Phosphatidylinositol 3–kinase, not extracellular signal-regulated kinase, regulates activation of the antioxidant-responsive element in IMR-32 human …
  1036. A specific function for Phosphatidylinositol 3–kinase α (p85α-p110α) in cell survival and for Phosphatidylinositol 3–kinase β (p85α-p110β) in de novo DNA synthesis of …
  1037. Stimulation of Phosphatidylinositol 3–kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins
  1038. Overexpression of Phosphatidylinositol 3–kinase in human lung cancer
  1039. Angiopoietin-1 regulates endothelial cell survival through the Phosphatidylinositol 3′-kinase/Akt signal transduction pathway
  1040. Restricted accumulation of Phosphatidylinositol 3–kinase products in a plasmalemmal subdomain during Fcγ receptor-mediated phagocytosis
  1041. Inhibition of mitogen-activated protein kinase and Phosphatidylinositol 3–kinase activity in MCF-7 cells prevents estrogen-induced mitogenesis
  1042. Role of Phosphatidylinositol 3–kinase and Rab5 effectors in phagosomal biogenesis and mycobacterial phagosome maturation arrest
  1043. Roles of Phosphatidylinositol 3–kinase in interferon-γ-dependent phosphorylation of STAT1 on serine 727 and activation of gene expression
  1044. Phosphatidylinositol 3–kinase is required for insulin-like growth factor-I–induced vascular smooth muscle cell proliferation and migration
  1045. Association of Phosphatidylinositol 3–kinase with nuclear transcription sites in higher plants
  1046. A novel positive feedback loop mediated by the docking protein Gab1 and Phosphatidylinositol 3–kinase in epidermal growth factor receptor signaling
  1047. Human cytomegalovirus up-regulates the Phosphatidylinositol 3–kinase (PI3-K) pathway: inhibition of PI3-K activity inhibits viral replication and virus-induced signaling
  1048. … endothelial growth factor induces expression of connective tissue growth factor via KDR, Flt1, and Phosphatidylinositol 3–kinase-akt-dependent pathways in …
  1049. Signaling complexes and protein-protein interactions involved in the activation of the Ras and Phosphatidylinositol 3–kinase pathways by the c-Ret receptor …
  1050. Hepatitis B virus X protein inhibits transforming growth factor-β-induced apoptosis through the activation of Phosphatidylinositol 3–kinase pathway
  1051. Haptotactic migration induced by midkine: involvement of protein-tyrosine phosphatase ζ, mitogen-activated protein kinase, and Phosphatidylinositol 3–kinase
  1052. The survival function of the Bcr-Abl oncogene is mediated by Bad-dependent and-independent pathways: roles for Phosphatidylinositol 3–kinase and Raf
  1053. Interferon α/β promotes cell survival by activating nuclear factor κB through Phosphatidylinositol 3–kinase and Akt
  1054. Angiopoietin-2 at high concentration can enhance endothelial cell survival through the Phosphatidylinositol 3′-kinase/Akt signal transduction pathway
  1055. A Phosphatidylinositol 3–kinase/Akt pathway, activated by tumor necrosis factor or interleukin-1, inhibits apoptosis but does not activate NFκB in human …
  1056. Induction of vascular endothelial growth factor receptors and Phosphatidylinositol 3′-kinase/Akt signaling by global cerebral ischemia in the rat
  1057. … life span of skeletal muscle satellite cells by enhancing g1/s cell cycle progression via the activation of Phosphatidylinositol 3′-kinase/akt signaling pathway
  1058. Phosphatidylinositol 3–kinase, Cdc42, and Rac1 act downstream of Ras in integrin-dependent neurite outgrowth in N1E-115 neuroblastoma cells
  1059. Adrenomedullin induces endothelium-dependent vasorelaxation via the Phosphatidylinositol 3–kinase/Akt–dependent pathway in rat aorta
  1060. Association of increased Phosphatidylinositol 3–kinase signaling with increased invasiveness and gelatinase activity in malignant gliomas
  1061. Glycogen synthase kinase–3β activity is critical for neuronal death caused by inhibiting Phosphatidylinositol 3–kinase or Akt but not for death caused by nerve …
  1062. The insulin-like growth factor-Phosphatidylinositol 3–kinase-Akt signaling pathway regulates myogenin expression in normal myogenic cells but not in …
  1063. Phosphatidylinositol 3–kinase/Akt signaling controls endothelial cell sensitivity to Fas-mediated apoptosis via regulation of FLICE-inhibitory protein (FLIP)
  1064. Inhibition of the Phosphatidylinositol 3–kinase pathway contributes to HT29 and Caco-2 intestinal cell differentiation
  1065. A member of Forkhead family transcription factor, FKHRL1, is one of the downstream molecules of Phosphatidylinositol 3–kinase-Akt activation pathway in …
  1066. Human SMG-1, a novel Phosphatidylinositol 3–kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the …
  1067. Redistribution of Bruton’s tyrosine kinase by activation of Phosphatidylinositol 3‐kinase and Rho‐family GTPases
  1068. Parallel and independent regulation of interleukin-3 mRNA turnover by Phosphatidylinositol 3–kinase and p38 mitogen-activated protein kinase
  1069. Phosphatidylinositol 3–kinase C2α contains a nuclear localization sequence and associates with nuclear speckles
  1070. The Phosphatidylinositol 3–kinase/AKT Signal Transduction Pathway Plays a Critical Role in the Expression of p21WAF1/CIP1/SDI1 Induced by Cisplatin and …
  1071. Amino acid-induced translation of TOP mRNAs is fully dependent on Phosphatidylinositol 3–kinase-mediated signaling, is partially inhibited by rapamycin, and is …
  1072. Nerve growth factor functions as a chemoattractant for mast cells through both mitogen-activated protein kinase and Phosphatidylinositol 3–kinase signaling pathways
  1073. Role of Phosphatidylinositol 3′ kinase and a Downstream Pleckstrin Homology Domain–Containing Protein in Controlling Chemotaxis inDictyostelium
  1074. Prevention of Phosphatidylinositol 3′-kinase-Akt survival signaling pathway during topotecan-induced apoptosis
  1075. Signal transduction by the chemokine receptor CXCR3: activation of Ras/ERK, Src, and Phosphatidylinositol 3–kinase/Akt controls cell migration and …
  1076. Oleate activates Phosphatidylinositol 3–kinase and promotes proliferation and reduces apoptosis of MDA-MB-231 breast cancer cells, whereas palmitate has opposite …
  1077. Myogenic differentiation requires signalling through both Phosphatidylinositol 3–kinase and p38 MAP kinase
  1078. Insulin-induced actin filament remodeling colocalizes actin with Phosphatidylinositol 3–kinase and GLUT4 in L6 myotubes
  1079. … up-regulates vascular endothelial growth factor expression in human glioblastoma cells via a pathway involving Phosphatidylinositol 3′-kinase and distinct from that …
  1080. Insulin Activates ATP-Sensitive K+ Channels in Pancreatic β-Cells Through a Phosphatidylinositol 3–kinase–Dependent Pathway
  1081. Interferon-α promotes survival of human primary B-lymphocytes via Phosphatidylinositol 3–kinase
  1082. … acetate induces neutrophil NADPH‐oxidase activity by two separate signal transduction pathways: dependent or independent of Phosphatidylinositol 3‐kinase
  1083. The role of genetic abnormalities of PTEN and the Phosphatidylinositol 3–kinase pathway in breast and ovarian tumorigenesis, prognosis, and therapy
  1084. Phosphatidylinositol 3–kinase inhibition enhances human sperm motility
  1085. Extracellular zinc activates p70 S6 kinase through the Phosphatidylinositol 3–kinase signaling pathway
  1086. Cooperative signaling between α6β4integrin and ErbB-2 receptor is required to promote Phosphatidylinositol 3–kinase-dependent invasion
  1087. … -inducible factor (HIF)-1α, HIF-2α, and vascular endothelial growth factor expression and their regulation by the Phosphatidylinositol 3′-kinase/Akt signaling pathway
  1088. α5β1 integrin protects intestinal epithelial cells from apoptosis through a Phosphatidylinositol 3–kinase and protein kinase B–dependent pathway
  1089. Protein kinase C-ζ phosphorylates insulin receptor substrate-1 and impairs its ability to activate Phosphatidylinositol 3–kinase in response to insulin
  1090. Cell cycle protein expression in vascular smooth muscle cells in vitro and in vivo is regulated through Phosphatidylinositol 3–kinase and mammalian target of …
  1091. The EphA8 receptor regulates integrin activity through p110γ Phosphatidylinositol–3 kinase in a tyrosine kinase activity-independent manner
  1092. The tyrosine phosphatase SHP-2 is required for mediating Phosphatidylinositol 3–kinase/Akt activation by growth factors
  1093. Growth hormone induces cellular insulin resistance by uncoupling Phosphatidylinositol 3–kinase and its downstream signals in 3T3-L1 adipocytes
  1094. … : Neuroprotection mediated by glial group‐II metabotropic glutamate receptors requires the activation of the MAP kinase and the Phosphatidylinositol‐3‐kinase …
  1095. Scatter factor/hepatocyte growth factor protects against cytotoxic death in human glioblastoma via Phosphatidylinositol 3–kinase-and AKT-dependent pathways
  1096. Cyclic AMP inhibits extracellular signal-regulated kinase and Phosphatidylinositol 3–kinase/Akt pathways by inhibiting Rap1
  1097. The classical progesterone receptor associates with p42 MAPK and is involved in Phosphatidylinositol 3–kinase signaling inXenopus oocytes
  1098. Cbl-b, a RING-type E3 ubiquitin ligase, targets Phosphatidylinositol 3–kinase for ubiquitination in T cells
  1099. The inhibition of Phosphatidylinositol‐3‐kinase induces neurite retraction and activates GSK3
  1100. Inhibitory mechanisms of tea polyphenols on the ultraviolet B-activated Phosphatidylinositol 3–kinase-dependent pathway
  1101. Preconditioning enhanced glucose uptake is mediated by p38 MAP kinase not by Phosphatidylinositol 3–kinase
  1102. Tec kinase signaling in T cells is regulated by Phosphatidylinositol 3–kinase and the Tec pleckstrin homology domain
  1103. Trypanosoma cruzi: Phosphatidylinositol 3–kinase and protein kinase B activation is associated with parasite invasion
  1104. A Phosphatidylinositol 3–kinase docking site in the cytoplasmic tail of the Jaagsiekte sheep retrovirus transmembrane protein is essential for envelope-induced …
  1105. Phosphatidylinositol 3‐kinase and mTOR mediate lipopolysaccharide‐stimulated nitric oxide production in macrophages via interferon‐β
  1106. Epstein-Barr virus immediate-early protein BRLF1 induces the lytic form of viral replication through a mechanism involving Phosphatidylinositol–3 kinase activation
  1107. L-leucine availability regulates Phosphatidylinositol 3–kinase, p70 S6 kinase and glycogen synthase kinase–3 activity in L6 muscle cells: evidence for the involvement …
  1108. Glycoprotein 130 regulates cardiac myocyte survival in doxorubicin-induced apoptosis through Phosphatidylinositol 3–kinase/Akt phosphorylation and Bcl-xL/caspase …
  1109. Role of extracellular signal-regulated kinase and Phosphatidylinositol–3 kinase in chemoattractant and LPS delay of constitutive neutrophil apoptosis
  1110. TNF-α-induced sphingosine 1-phosphate inhibits apoptosis through a Phosphatidylinositol 3–kinase/Akt pathway in human hepatocytes
  1111. Activation of Phosphatidylinositol 3–kinase and Akt bytert-butylhydroquinone is responsible for antioxidant response element-mediated rGSTA2 induction in H4IIE cells
  1112. Erythropoietin regulates vascular smooth muscle cell apoptosis by a Phosphatidylinositol 3 kinase-dependent pathway
  1113. S338 phosphorylation of Raf-1 is independent of Phosphatidylinositol 3–kinase and Pak3
  1114. … factor rapidly increases activity and cell surface expression of the EAAC1 subtype of glutamate transporter through activation of Phosphatidylinositol 3–kinase
  1115. Oncogenic Ras blocks anoikis by activation of a novel effector pathway independent of Phosphatidylinositol 3–kinase
  1116. Up-regulation of urokinase-type plasminogen activator by insulin-like growth factor-I depends upon Phosphatidylinositol–3 kinase and mitogen-activated protein …
  1117. TEL-JAK2 mediates constitutive activation of the Phosphatidylinositol 3′-kinase/protein kinase B signaling pathway
  1118. An inhibitory role of the Phosphatidylinositol 3–kinase-signaling pathway in vascular endothelial growth factor-induced tissue factor expression
  1119. … fructose absorption by the extracellular signal-regulated kinase, p38 mitogen-activated kinase and Phosphatidylinositol 3–kinase intracellular signalling pathways …
  1120. c-Src is required for glial cell line-derived neurotrophic factor (GDNF) family ligand-mediated neuronal survival via a Phosphatidylinositol–3 kinase (PI-3K)-dependent …
  1121. … neurotrophic factor (BDNF) induces dendritic targeting of BDNF and tyrosine kinase B mRNAs in hippocampal neurons through a Phosphatidylinositol–3 kinase …
  1122. Urokinase stimulates human vascular smooth muscle cell migration via a Phosphatidylinositol 3–kinase-Tyk2 interaction
  1123. Phosphatidylinositol 3‐kinase and ERK are required for NF‐κB activation but not for phagocytosis
  1124. Phosphatidylinositol 3–kinase potentiates, but does not trigger, T cell proliferation mediated by the IL-2 receptor
  1125. Quercetin inhibits Shc-and Phosphatidylinositol 3–kinase-mediated c-Jun N-terminal kinase activation by angiotensin II in cultured rat aortic smooth muscle cells
  1126. Differential effects of Phosphatidylinositol 3–kinase inhibition on intracellular signals regulating GLUT4 translocation and glucose transport
  1127. Regulation of gene expression by glucose in pancreatic β-cells (MIN6) via insulin secretion and activation of Phosphatidylinositol 3′-kinase
  1128. The essential role of Phosphatidylinositol 3–kinase and of p38 mitogen-activated protein kinase activation in the antioxidant response element-mediated rGSTA2 …
  1129. Phosphatidylinositol 3–kinase signaling is important for smooth muscle cell replication after arterial injury
  1130. Trypanosoma cruzi trans-sialidase: A potent and specific survival factor for human Schwann cells by means of Phosphatidylinositol 3–kinase/Akt signaling
  1131. C5b-9 terminal complement complex protects oligodendrocytes from death by regulating Bad through Phosphatidylinositol 3–kinase/Akt pathway
  1132. Putative role of the Phosphatidylinositol 3–kinase—Akt signaling pathway in the survival of granulosa cells
  1133. Activation of Phosphatidylinositol–3 kinase (PI-3K) and extracellular regulated kinases (Erk1/2) is involved in muscarinic receptor-mediated DNA synthesis in neural …
  1134. Insulin accelerates inter-endosomal GLUT4 traffic via Phosphatidylinositol 3–kinase and protein kinase B
  1135. The Ras/Phosphatidylinositol 3–kinase and Ras/ERK pathways function as independent survival modules each of which inhibits a distinct apoptotic signaling …
  1136. A Novel B Lymphocyte–associated Adaptor Protein, Bam32, Regulates Antigen Receptor Signaling Downstream of Phosphatidylinositol 3–kinase
  1137. Involvement of the pathway Phosphatidylinositol–3–kinase/AKT-1 in the establishment of the survival response to ionizing radiation
  1138. Reduction of potassium currents and Phosphatidylinositol 3–kinase-dependent AKT phosphorylation by tumor necrosis factor-α rescues axotomized retinal ganglion …
  1139. Novel role of Phosphatidylinositol 3–kinase in CD28-mediated costimulation
  1140. Hepatocyte growth factor protects cultured rat cerebellar granule neurons from apoptosis via the Phosphatidylinositol‐3 kinase/Akt pathway
  1141. Halenaquinone, a novel Phosphatidylinositol 3–kinase inhibitor from a marine sponge, induces apoptosis in PC12 cells
  1142. Stem cell factor induces Phosphatidylinositol 3′-kinase–dependent Lyn/Tec/Dok-1 complex formation in hematopoietic cells
  1143. X-linked inhibitor of apoptosis protein activates the Phosphatidylinositol 3–kinase/Akt pathway in rat granulosa cells during follicular development
  1144. Phosphatidylinositol–3 kinase and extracellular signal-regulated kinase mediate the chemotactic and mitogenic effects of insulin-like growth factor-I in human hepatic …
  1145. Thapsigargin-induced degranulation of mast cells is dependent on transient activation of Phosphatidylinositol–3 kinase
  1146. Phosphatidylinositol 3–kinase is necessary but not sufficient for thrombopoietin-induced proliferation in engineered Mpl-bearing cell lines as well as in primary …
  1147. Specific requirement for the p85-p110α Phosphatidylinositol 3–kinase during epidermal growth factor-stimulated actin nucleation in breast cancer cells
  1148. Cooperative regulation of Mcl-1 by Janus kinase/stat and Phosphatidylinositol 3–kinase contribute to granulocyte-macrophage colony-stimulating factor-delayed …
  1149. Phosphatidylinositol–3 kinase acts in parallel to the ERK MAP kinase in the FGF pathway during Xenopus mesoderm induction
  1150. Phosphatidylinositol 3′ kinase signaling in mammary tumorigenesis
  1151. Neuregulin rescues PC12-ErbB4 cells from cell death induced by H2O2: regulation of reactive oxygen species levels by Phosphatidylinositol 3–kinase
  1152. Apoptosis suppression by Raf-1 and MEK1 requires MEK-and Phosphatidylinositol 3–kinase-dependent signals
  1153. Insulin regulates alternative splicing of protein kinase C βII through a Phosphatidylinositol 3–kinase-dependent pathway involving the nuclear serine/arginine …
  1154. fMet-Leu-Phe stimulates proinflammatory cytokine gene expression in human peripheral blood monocytes: the role of Phosphatidylinositol 3–kinase
  1155. Retention of PDGFR-β function in mice in the absence of Phosphatidylinositol 3′-kinase and phospholipase Cγ signaling pathways
  1156. Activation of the Ral and Phosphatidylinositol 3′ kinase signaling pathways by the ras-related protein TC21
  1157. The SH3 domain directs acto-myosin-dependent targeting of v-Src to focal adhesions via Phosphatidylinositol 3–kinase
  1158. Caveolin 1-mediated regulation of receptor tyrosine kinase-associated Phosphatidylinositol 3–kinase activity by ceramide
  1159. Phosphatidylinositol 3–kinase activation and interaction with focal adhesion kinase in Escherichia coli K1 invasion of human brain microvascular endothelial …
  1160. Targets of B-cell antigen receptor signaling: the Phosphatidylinositol 3–kinase/Akt/glycogen synthase kinase–3 signaling pathway and the Rap1 GTPase.
  1161. Regulation of Cyclin D1 Expression and DNA Synthesis by Phosphatidylinositol 3–kinase in Airway Smooth Muscle Cells
  1162. Interleukin‐6 activates Phosphatidylinositol‐3 kinase, which inhibits apoptosis in human prostate cancer cell lines
  1163. Cooperation between STAT5 and Phosphatidylinositol 3–kinase in the IL-3-dependent survival of a bone marrow derived cell line
  1164. Endocytosis and nuclear trafficking of adeno-associated virus type 2 are controlled by rac1 and Phosphatidylinositol–3 kinase activation
  1165. Phosphatidylinositol 3–kinase-dependent stabilization of α1(I) collagen mRNA in human lung fibroblasts
  1166. GTPases and Phosphatidylinositol 3–kinase are critical for insulin-like growth factor-I-mediated Schwann cell motility
  1167. The role of Phosphatidylinositol 3–kinase and the mitogen-activated protein kinases in insulin-like growth factor-I-mediated effects in vascular endothelial cells
  1168. Thrombopoietin potentiates collagen receptor signaling in platelets through a Phosphatidylinositol 3–kinase–dependent pathway
  1169. Regulation of intracellular trafficking of the EGF receptor by Rab5 in the absence of Phosphatidylinositol 3–kinase activity
  1170. NK cell‐mediated lysis of autologous antigen‐presenting cells is triggered by the engagement of the Phosphatidylinositol 3‐kinase upon ligation of the natural …
  1171. Role of Gab proteins in Phosphatidylinositol 3–kinase activation by thrombopoietin (Tpo)
  1172. Phosphatidylinositol 3–kinase and NF-κB/Rel are at the divergence of CD40-mediated proliferation and survival pathways
  1173. Distinct roles for extracellular-signal-regulated protein kinase (ERK) mitogen-activated protein kinases and Phosphatidylinositol 3–kinase in the regulation of Mcl-1 …
  1174. … vascular endothelial cells by a phosphatase inhibitor: possible involvement of extracellular signal-regulated kinase and Phosphatidylinositol 3–kinase
  1175. Growth hormone exerts antiapoptotic and proliferative effects through two different pathways involving nuclear factor-κB and Phosphatidylinositol 3–kinase
  1176. Factor VIIa/tissue factor-induced signaling via activation of Src-like kinases, Phosphatidylinositol 3–kinase, and Rac
  1177. … agonists increase expression of glutamate transporter GLT-1 in astrocytes through pathways dependent on Phosphatidylinositol 3–kinase and transcription factor NF …
  1178. Both src-dependent and-independent mechanisms mediate Phosphatidylinositol 3–kinase regulation of colony-stimulating factor 1-activated mitogen-activated protein …
  1179. Regulation of nuclear factor κB transactivation: implication of Phosphatidylinositol 3–kinase and protein kinase C ζ in c-Rel activation by tumor necrosis factor α
  1180. Phosphatidylinositol 3‐kinase and the control of endosome dynamics: new players defined by structural motifs
  1181. … of tyrosine residues in vascular endothelial growth factor receptor-2/FLK-1 involved in activation of Phosphatidylinositol 3–kinase and cell proliferation
  1182. Tyr612 and Tyr632 in human insulin receptor substrate-1 are important for full activation of insulin-stimulated Phosphatidylinositol 3–kinase activity and translocation of …
  1183. … of tyrosine residues in constitutively activated fibroblast growth factor receptor 3 involved in mitogenesis, Stat activation, and Phosphatidylinositol 3–kinase activation
  1184. 1α, 25-Dihydroxyvitamin D3-induced monocyte antimycobacterial activity is regulated by Phosphatidylinositol 3–kinase and mediated by the NADPH …
  1185. … effects of morphine in peroxynitrite-induced apoptosis of primary rat neonatal astrocytes: potential involvement of G protein and Phosphatidylinositol 3–kinase (PI3 …
  1186. Phosphatidylinositol 3–kinase–dependent translocation of phospholipase Cγ2 in mouse megakaryocytes is independent of Bruton tyrosine kinase translocation
  1187. Phosphatidylinositol 3–kinase-dependent extracellular calcium influx is essential for CX3CR1-mediated activation of the mitogen-activated protein kinase …
  1188. Up-regulation of endothelial nitric-oxide synthase promoter by the Phosphatidylinositol 3–kinase γ/Janus kinase 2/MEK-1-dependent pathway
  1189. … domain of Flt-1 (VEGFR-1) constitutively inhibits vascular endothelial growth factor-dependent Phosphatidylinositol 3′-kinase activation and endothelial cell …
  1190. ErbB2-overexpressing human mammary carcinoma cells display an increased requirement for the Phosphatidylinositol 3–kinase signaling pathway in anchorage …
  1191. Regulatory role of Phosphatidylinositol 3–kinase on TNF-α–Induced cyclooxygenase 2 expression in colonic epithelial cells
  1192. Cytokines prevent dexamethasone-induced apoptosis via the activation of mitogen-activated protein kinase and Phosphatidylinositol 3–kinase pathways in a new …
  1193. The Gab1 docking protein links the b cell antigen receptor to the Phosphatidylinositol 3–kinase/Akt signaling pathway and to the SHP2 tyrosine phosphatase
  1194. Phosphatidylinositol 3–kinase mediates integrin-dependent NF-(κ) B and MAPK activation through separate signaling pathways
  1195. Diversification of cardiac insulin signaling involves the p85α/β subunits of Phosphatidylinositol 3–kinase
  1196. The expression of the p85α subunit of Phosphatidylinositol 3–kinase is induced by activation of the peroxisome proliferator-activated receptor γ in human adipocytes
  1197. Stimulation of human neutrophils by chemotactic factors is associated with the activation of Phosphatidylinositol 3–kinase γ
  1198. Roles of insulin receptor substrate-1, Phosphatidylinositol 3–kinase, and release of intracellular Ca2+ stores in insulin-stimulated insulin secretion in β-cells
  1199. Differential regulation of the Phosphatidylinositol 3–kinase/Akt and p70 S6 kinase pathways by the α1A-adrenergic receptor in rat-1 fibroblasts
  1200. Phosphatidylinositol 3–kinase, protein kinase B and ribosomal S6 kinases in the stimulation of thyroid epithelial cell proliferation by cAMP and growth factors in the …
  1201. Src transduces erythropoietin-induced differentiation signals through Phosphatidylinositol 3–kinase
  1202. Glial cell line-derived neurotrophic factor-stimulated Phosphatidylinositol 3–kinase and Akt activities exert opposing effects on the ERK pathway: importance …
  1203. The bile acid–activated Phosphatidylinositol 3–kinase pathway inhibits Fas apoptosis upstream of bid in rodent hepatocytes
  1204. Cross-talk between Phosphatidylinositol 3–kinase and sphingomyelinase pathways as a mechanism for cell survival/death decisions
  1205. Reciprocal regulation of glycogen phosphorylase and glycogen synthase by insulin involving Phosphatidylinositol–3 kinase and protein phosphatase-1 in HepG2 cells
  1206. Stimulation of tetrahydrobiopterin synthesis induced by insulin: possible involvement of Phosphatidylinositol 3–kinase
  1207. Insulin-like growth factor (IGF) binding protein-3 potentiation of IGF action is mediated through the Phosphatidylinositol–3–kinase pathway and is associated with …
  1208. Glut-1 Translocation in FRTL-5 Thyroid Cells: Role of Phosphatidylinositol 3–kinase and N-Glycosylation
  1209. Persistent activation of Phosphatidylinositol 3–kinase causes insulin resistance due to accelerated insulin-induced insulin receptor substrate-1 degradation in 3T3-L1 …
  1210. Five isoforms of the Phosphatidylinositol 3‐kinase regulatory subunit exhibit different associations with receptor tyrosine kinases and their tyrosine phosphorylations
  1211. Phosphatidylinositol–3 kinase regulates p21ras activation during IgE-mediated stimulation of human basophils
  1212. Ceramide regulates lipopolysaccharide-induced Phosphatidylinositol 3–kinase and Akt activity in human alveolar macrophages
  1213. Insulin stimulates NHE1 activity by sequential activation of Phosphatidylinositol 3‐kinase and protein kinase C ζ in human erythrocytes
  1214. Evidence for a Functional Association between Phosphatidylinositol 3–kinase and c-src in the Spreading Response of Osteoclasts to Colony-Stimulating Factor-1
  1215. A Specific Role of Phosphatidylinositol 3–kinase γ: A Regulation of Autonomic Ca2+ Oscillations in Cardiac Cells
  1216. Stabilization of cyclin D1 mRNA via the Phosphatidylinositol 3–kinase pathway in MCF-7 human breast cancer cells
  1217. Protein phosphatase 2A and Phosphatidylinositol 3–kinase regulate the activity of Sp1-responsive promoters
  1218. Tyrosine phosphorylation of the p85 subunit of Phosphatidylinositol 3–kinase correlates with high proliferation rates in sublines derived from the Jurkat leukemia
  1219. Constitutively active Phosphatidylinositol 3–kinase and AKT are sufficient to stimulate the epithelial Na+/H+ exchanger 3
  1220. Insulin-like growth factor-1 protects H9c2 cardiac myoblasts from oxidative stress-induced apoptosis via Phosphatidylinositol 3–kinase and extracellular signal …
  1221. … protein phosphatase by insulin in vascular smooth muscle cells: evaluation of the role of Rho kinase and Phosphatidylinositol–3–kinase-dependent signaling pathways
  1222. Phosphatidylinositol 3′-kinase blocks CD95 aggregation and caspase-8 cleavage at the death-inducing signaling complex by modulating lateral diffusion of CD95
  1223. Platelet-derived growth factor activates porcine thecal cell Phosphatidylinositol–3–kinase-Akt/PKB and Ras-extracellular signal-regulated kinase-1/2 kinase signaling …
  1224. Insulin-like growth factor I-induced degradation of insulin receptor substrate 1 is mediated by the 26S proteasome and blocked by Phosphatidylinositol 3′-kinase …
  1225. 15-Deoxy-Δ12, 14-prostaglandin J2 and thiazolidinediones activate the MEK/ERK pathway through Phosphatidylinositol 3–kinase in vascular smooth muscle …
  1226. Association of Phosphatidylinositol 3–kinase composed of p110β-catalytic and p85-regulatory subunits with the small GTPase Rab5
  1227. Interleukins 4 and 13 increase intestinal epithelial permeability by a Phosphatidylinositol 3–kinase pathway: lack of evidence for STAT 6 involvement
  1228. ERK regulates the hepatocyte growth factor-mediated interaction of Gab1 and the Phosphatidylinositol 3–kinase
  1229. Intracellular signals that control cell proliferation in mammalian balance epithelia: key roles for Phosphatidylinositol–3 kinase, mammalian target of rapamycin, and S6 …
  1230. Cutting edge: gab2 mediates an inhibitory Phosphatidylinositol 3′-kinase pathway in T cell antigen receptor signaling
  1231. Brain‐derived neurotrophic factor induces excitotoxic sensitivity in cultured embryonic rat spinal motor neurons through activation of the Phosphatidylinositol 3‐kinase …
  1232. Phosphatidylinositol 3–kinase signaling to Akt mediates survival in isolated canine islets of Langerhans
  1233. … (VEGF) receptor-1 down-modulates VPF/VEGF receptor-2-mediated endothelial cell proliferation, but not migration, through Phosphatidylinositol 3–kinase …
  1234. Involvement of a Phosphatidylinositol 3–kinase–p38 mitogen activated protein kinase pathway in antigen-induced IL-4 production in mast cells
  1235. … growth factor/scatter factor stimulates migration of rat mammary fibroblasts through both mitogen‐activated protein kinase and Phosphatidylinositol 3‐kinase/Akt …
  1236. Nerve Growth Factor Uses Ras/ERK and Phosphatidylinositol 3–kinase Cascades to Up-regulate theN-Methyl-d-aspartate Receptor 1 Promoter
  1237. Glial cell line-derived neurotrophic factor promotes survival and induces differentiation through the Phosphatidylinositol 3–kinase and mitogen-activated protein kinase …
  1238. A Phosphatidylinositol 3–kinase of Candida albicans influences adhesion, filamentous growth and virulence
  1239. A link between insulin resistance and hyperinsulinemia: inhibitors of Phosphatidylinositol 3–kinase augment glucose-induced insulin secretion from islets of lean, but …
  1240. Requirement of Phosphatidylinositol 3–kinase activity for translocation of exogenous aFGF to the cytosol and nucleus
  1241. In vitro hormone induction of final oocyte maturation in striped bass (Morone saxatilis) follicles is inhibited by blockers of Phosphatidylinositol 3–kinase activity
  1242. Tyrosine kinase-dependent, Phosphatidylinositol 3′-kinase, and mitogen-activated protein kinase-independent signaling pathways prevent lung adenocarcinoma …
  1243. … preproinsulin gene expression and nucleartrans-location of pancreatic duodenum homeobox-1 require activation of Phosphatidylinositol 3–kinase but not p38 …
  1244. Activation of Phosphatidylinositol 3‐kinase by a complex of p59fyn and the receptor tyrosine kinase Xmrk is involved in malignant transformation of pigment cells
  1245. … protein-5 helps accelerate progression to androgen-independence in the human prostate LNCaP tumor model through activation of Phosphatidylinositol 3′-kinase …
  1246. Dual Signaling via Protein kinase C and Phosphatidylinositol 3′-kinase/Akt Contributes to Bradykinin B2Receptor-induced Cardioprotection in Guinea Pig Hearts
  1247. Insulin-like growth factor I potentiates kainate receptors through a Phosphatidylinositol 3–kinase dependent pathway
  1248. Regulation of Id2 gene expression by the insulin-like growth factor I receptor requires signaling by Phosphatidylinositol 3–kinase
  1249. Basic fibroblast growth factor stimulates surface expression and activity of Na+/H+ exchanger NHE3 via mechanism involving Phosphatidylinositol 3–kinase
  1250. Aggretin, a C-type lectin protein, induces platelet aggregation via integrin α2β1 and GPIb in a Phosphatidylinositol 3–kinase independent pathway
  1251. A molecular basis for T cell suppression by IL‐10: CD28‐associated IL‐10 receptor inhibits CD28 tyrosine phosphorylation and Phosphatidylinositol 3‐kinase binding
  1252. Regulation of oxidative stress-induced calcium release by Phosphatidylinositol 3–kinase and Bruton’s tyrosine kinase in B cells
  1253. Cyclooxygenase-2 inducing Mcl-1-dependent survival mechanism in human lung adenocarcinoma CL1. 0 cells: involvement of Phosphatidylinositol 3–kinase …
  1254. Impaired muscle glycogen synthase in type 2 diabetes is associated with diminished Phosphatidylinositol 3–kinase activation
  1255. … and luteinizing hormone in cultured porcine granulosa-luteal cells: possible convergence of protein kinase a, Phosphatidylinositol 3–kinase, and mitogen-activated …
  1256. Role of Phosphatidylinositol 3–kinase and specific protein kinase B isoforms in the suppression of apoptosis mediated by the Abelson protein-tyrosine kinase
  1257. The expression of the γ subunit of Na-K-ATPase is regulated by osmolality via C-terminal Jun kinase and Phosphatidylinositol 3–kinase-dependent mechanisms
  1258. Ras activation of Phosphatidylinositol 3–kinase and Akt
  1259. Involvement of Phosphatidylinositol 3–kinase and mitogen-activated protein kinases in glycine-extended gastrin-induced dissociation and migration of gastric …
  1260. Direct interaction between the cytoplasmic tail of ADAM 12 and the Src homology 3 domain of p85α activates Phosphatidylinositol 3–kinase in C2C12 cells
  1261. Regulation of epidermal growth factor receptor endocytosis by wortmannin through activation of Rab5 rather than inhibition of Phosphatidylinositol 3–kinase
  1262. The insulin receptor substrate (IRS)-1 recruits Phosphatidylinositol 3–kinase to Ret: evidence for a competition between Shc and IRS-1 for the binding to Ret
  1263. Activation of the Phosphatidylinositol 3–kinase-Akt/protein kinase B signaling pathway in arachidonic acid-stimulated human myeloid and endothelial cells …
  1264. An SH2-domain-containing kinase negatively regulates the Phosphatidylinositol–3 kinase pathway
  1265. The Phosphatidylinositol 3–kinase pathway selectively controls sIL-1RA not interleukin-1β production in the septic leukocytes
  1266. T cell activation induces direct binding of the Crk adapter protein to the regulatory subunit of Phosphatidylinositol 3–kinase (p85) via a complex mechanism …
  1267. Involvement of phospholipase D in sphingosine 1-phosphate-induced activation of Phosphatidylinositol 3–kinase and Akt in Chinese hamster ovary cells …
  1268. The T cell antigen receptor activates Phosphatidylinositol 3‐kinase‐regulated serine kinases protein kinase B and ribosomal S6 kinase 1
  1269. Rac and Phosphatidylinositol 3–kinase regulate the protein kinase B in FcεRI signaling in RBL 2H3 mast cells
  1270. Activation of Phosphatidylinositol 3 kinase by muscarinic receptors in astrocytoma cells
  1271. … with Thyrotropin-induced G1-S Transition Mediated by cAMP-dependent Protein kinase and Phosphatidylinositol 3–kinase: INVOLVEMENT OF RhoA AND …
  1272. Expression of a constitutively active form of Phosphatidylinositol 3–kinase inhibits the induction of nitric oxide synthase in human astrocytes
  1273. Role of Phosphatidylinositol 3–kinase in anti-IgM-and anti-IgD-induced apoptosis in B cell lymphomas
  1274. Insulin-mediated cell proliferation and survival involve inhibition of c-Jun N-terminal kinases through a Phosphatidylinositol 3–kinase-and mitogen-activated protein …
  1275. Enteric neuroblasts require the Phosphatidylinositol 3‐kinase pathway for GDNF‐stimulated proliferation
  1276. The CK2 phosphorylation of vitronectin: Promotion of cell adhesion via the αvβ3–Phosphatidylinositol 3–kinase pathway
  1277. β-Adrenergic stimulation of rat cardiac fibroblasts promotes protein synthesis via the activation of Phosphatidylinositol 3–kinase
  1278. … 1 fusion protein of the t (6; 8) translocation induces cell survival mediated by mitogen-activated protein kinase and Phosphatidylinositol 3–kinase/Akt/mTOR pathways
  1279. Ca2+-and Phosphatidylinositol 3–kinase-dependent nitric oxide generation in lung endothelial cells in situ with ischemia
  1280. Compartmentalization and insulin-induced translocations of insulin receptor substrates, Phosphatidylinositol 3–kinase, and protein kinase B in rat liver
  1281. Sites of action of protein kinase C and Phosphatidylinositol 3–kinase are distinct in oxidized low density lipoprotein-induced macrophage proliferation
  1282. Role of Phosphatidylinositol–3 kinase and its association with Gab1 in thrombopoietin-mediated up-regulation of platelet function
  1283. Heregulin‐β is especially potent in activating Phosphatidylinositol 3‐kinase in nontransformed human mammary epithelial cells
  1284. Interaction of the insulin receptor β-subunit with Phosphatidylinositol 3–kinase in bovine ROS
  1285. IL‐12 selectively regulates STAT4 via Phosphatidylinositol 3‐kinase and Ras‐independent signal transduction pathways
  1286. Phosphatidylinositol 3–kinase stimulates muscle differentiation by activating p38 mitogen-activated protein kinase
  1287. … rendered erythropoietin independent by infection with Friend spleen focus-forming virus show constitutive activation of Phosphatidylinositol 3–kinase and Akt kinase …
  1288. Epidermal growth factor-induced Phosphatidylinositol 3–kinase activation and DNA synthesis: identification of Grb2-associated binder 2 as the major mediator …
  1289. Platelet‐activating factor activates mitogen‐activated protein kinases through the activation of Phosphatidylinositol 3‐kinase and tyrosine kinase in human eosinophils
  1290. Phosphatidylinositol 3–kinase is required for the trophic, but not the survival-promoting, actions of NGF on sympathetic neurons
  1291. HIV‐1 Tat protein down‐regulates CREB transcription factor expression in PC12 neuronal cells through a Phosphatidylinositol 3‐kinase/AKT/cyclic nucleoside …
  1292. LY 294002, an inhibitor of Phosphatidylinositol 3–kinase, inhibits GH-mediated expression of the IGF-I gene in rat hepatocytes
  1293. Hck enhances the adherence of lipopolysaccharide-stimulated macrophages via Cbl and Phosphatidylinositol 3–kinase
  1294. … apoptosis by crystals of calcium pyrophosphate dihydrate is mediated by the extracellular signal-regulated kinase and Phosphatidylinositol 3–kinase/Akt pathways up …
  1295. Phosphatidylinositol 3–kinase confers resistance to encephalomyocarditis and herpes simplex virus-induced cell death through the activation of distinct downstream …
  1296. Regulation of p85α Phosphatidylinositol–3–kinase expression by peroxisome proliferator-activated receptors (PPARs) in human muscle cells
  1297. The Rho/Rho‐kinase and the Phosphatidylinositol 3‐kinase pathways are essential for spontaneous locomotion of Walker 256 carcinosarcoma cells
  1298. Interactions between Phosphatidylinositol 3–kinase and nitric oxide: explaining the paradox
  1299. The roles of Phosphatidylinositol 3–kinase and protein kinase Cζ for thrombopoietin-induced mitogen-activated protein kinase activation in primary murine …
  1300. Inhibition of Phosphatidylinositol–3 kinase/Akt or mitogen-activated protein kinase signaling sensitizes endothelial cells to TNF-α cytotoxicity
  1301. Activation of the Phosphatidylinositol 3–kinase/Akt pathway protects against interleukin-3 starvation but not DNA damage-induced apoptosis
  1302. Enhanced cell killing by overexpression of dominant‐negative Phosphatidylinositol 3‐kinase subunit, Δp85, following genotoxic stresses
  1303. … is required for efficient induction of chronic myeloid leukemia–like disease in mice but not for lymphoid leukemogenesis or activation of Phosphatidylinositol 3–kinase
  1304. Phosphatidylinositol 3–kinase activity regulates α-thrombin-stimulated G1 progression by its effect on cyclin D1 expression and cyclin-dependent kinase 4 …
  1305. … promotes the expression of peroxisome proliferator-activated receptor γ in vascular smooth muscle cells by a Phosphatidylinositol 3–kinase/Akt signaling pathway
  1306. Mechanism of Phosphatidylinositol 3–kinase-dependent increases in BAC1. 2F5 macrophage-like cell density in response to M-CSF: Phosphatidylinositol 3–kinase …
  1307. … effect of hepatocyte growth factor and fibronectin in anchorage-independent survival of mammary carcinoma cells: requirement for Phosphatidylinositol 3–kinase …
  1308. Interleukin-6 protects rat PC12 cells from serum deprivation or chemotherapeutic agents through the Phosphatidylinositol 3–kinase and STAT3 pathways
  1309. Phosphatidylinositol 3–kinase and Ras/mitogen-activated protein kinase signaling pathways are required for the regulation of 5-aminolevulinate synthase gene …
  1310. Tyrosine kinase and Phosphatidylinositol 3–kinase activation are required for cyclic adenosine 3′, 5′-monophosphate-dependent potentiation of deoxyribonucleic …
  1311. LFA-1-mediated costimulation of CD8+ T cell proliferation requires Phosphatidylinositol 3–kinase activity
  1312. Phosphatidylinositol–3′ kinase-dependent vesicle formation in macrophages in response to macrophage colony stimulating factor
  1313. A Phosphatidylinositol 3‐kinase of Candida albicans: molecular cloning and characterization
  1314. Tyrosine phosphorylation is involved in Phosphatidylinositol 3–kinase activation in bovine rod outer segments
  1315. Phosphatidylinositol 3–kinase-dependent pathways oppose fas-induced apoptosis and limit chloride secretion in human intestinal epithelial cells: implications …
  1316. Phosphatidylinositol 3‐kinase activity is required for the expression of glial fibrillary acidic protein upon cAMP‐dependent induction of differentiation in rat C6 glioma
  1317. Phosphatidylinositol 3–kinase in cumulus cells and oocytes is responsible for activation of oocyte mitogen-activated protein kinase during meiotic progression beyond …
  1318. Neurotrophic factor protection against ethanol toxicity in rat cerebellar granule cell cultures requires Phosphatidylinositol 3–kinase activation
  1319. Phosphatidylinositol 3–kinase activity in murine motoneuron disease: the progressive motor neuropathy mouse
  1320. Phosphatidylinositol 3‐kinase Translocates to the Nucleus of Osteoblast‐Like MC3T3‐E1 Cells in Response to Insulin‐Like Growth Factor I and Platelet‐Derived …
  1321. … a combined treatment with epidermal growth factor and transforming growth factor-β in rat hepatocytes: role of Phosphatidylinositol 3–kinase-induced AP-1 …
  1322. Phosphatidylinositol 3–kinase is required for adherens junction-dependent mammary epithelial cell spheroid formation
  1323. Role of Phosphatidylinositol 3–kinase in acetylcholine-induced dilatation of rat basilar artery
  1324. … growth factor receptor 1 expressed in Xenopus laevis oocytes after fibroblast growth factor 1 addition: Role of Grb2, Phosphatidylinositol 3‐kinase, Src tyrosine kinase …
  1325. Effect of long-term caloric restriction on GLUT4, Phosphatidylinositol–3 kinase p85 subunit, and insulin receptor substrate-1 protein levels in rhesus monkey skeletal …
  1326. Phosphatidylinositol 3–kinase inhibitors, Wortmannin or LY294002, inhibited accumulation of p21 protein after γ-irradiation by stabilization of the protein
  1327. Further evidence for the involvement of insulin receptor substrates in epidermal growth factor‐induced activation of Phosphatidylinositol 3‐kinase
  1328. Rosiglitazone (BRL 49653) enhances insulin secretory response via Phosphatidylinositol 3–kinase pathway
  1329. Anchorage-independent activation of mitogen-activated protein kinase through Phosphatidylinositol–3 kinase by insulin-like growth factor I
  1330. Regulation of gene expression during severe caloric restriction: lack of induction of p85alpha Phosphatidylinositol 3–kinase mRNA in skeletal muscle of patients with …
  1331. Tyrosine phosphorylation of the catalytic subunit p110 of Phosphatidylinositol–3 kinase induced by HMG-CoA reductase inhibitor inhibits its kinase activity in …
  1332. Hepatocyte growth factor-induced differential activation of phospholipase Cγ1 and Phosphatidylinositol 3–kinase is regulated by tyrosine phosphatase SHP-1 …
  1333. MIP-1α induces activation of Phosphatidylinositol–3 kinase that associates with Pyk-2 and is necessary for B-cell migration
  1334. Phosphatidylinositol–3–kinase activation and atypical protein kinase C ζ phosphorylation characterize the DMSO signalling in erythroleukemia cells
  1335. Inhibition of Phosphatidylinositol 3–kinase and protein kinase C attenuates extracellular matrix protein-induced vascular smooth muscle cell chemotaxis
  1336. Phosphatidylinositol 3‐kinase inhibitors prevent mouse cytotoxic T‐cell development in vitro
  1337. Phosphatidylinositol 3′-kinase-mediated calcium mobilization regulates chemotaxis in phosphatidic acid-stimulated human neutrophils
  1338. Membrane depolarization-mediated survival of sympathetic neurons occurs through both Phosphatidylinositol 3–kinase-and CaM kinase II-dependent pathways
  1339. Involvement of insulin receptor substrates in epidermal growth factor induced activation of Phosphatidylinositol 3‐kinase in rat hepatocyte primary culture
  1340. Surfactant protein A regulates pulmonary surfactant secretion via activation of Phosphatidylinositol 3–kinase in type II alveolar cells
  1341. Subcellular localization of insulin receptor substrate family proteins associated with Phosphatidylinositol 3–kinase activity and alterations in lipolysis in primary mouse …
  1342. Phosphatidylinositol 3–kinase in zymosan-and bacteria-induced signalling to mobilisation of arachidonic acid in macrophages
  1343. A human class II MHC–derived peptide antagonizes Phosphatidylinositol 3–kinase to block IL-2 signaling
  1344. Induction of Phosphatidylinositol 3–kinase and serine-threonine kinase-like immunoreactivity in rabbit spinal cord after transient ischemia
  1345. Phosphorylation of unnatural Phosphatidylinositols with Phosphatidylinositol 3–kinase
  1346. Hepatic glutamine transporter activation in burn injury: role of amino acids and Phosphatidylinositol–3–kinase
  1347. VCAM-1 activates Phosphatidylinositol 3–kinase and induces p120Cbl phosphorylation in human airway smooth muscle cells
  1348. Inhibition of Phosphatidylinositol 3–kinase or Mitogen-Activated Protein kinase kinase Leads to Suppression of p34cdc2 kinase Activity and Meiotic Progression …
  1349. DNA Damage-Induced G1 Arrest in Hematopoietic Cells Is Overridden following Phosphatidylinositol 3–kinase-Dependent Activation of Cyclin-Dependent kinase 2
  1350. Phosphatidylinositol 3–kinase and trypsin activation in pancreatitis
  1351. Expression of a prenylation-deficient Rab4 inhibits the GLUT4 translocation induced by active Phosphatidylinositol 3–kinase and protein kinase B
  1352. … induction of tissue inhibitors of metalloproteinase-1 expression and secretion is mediated by mitogen-activated protein kinase and Phosphatidylinositol 3–kinase …
  1353. Interaction of oestrogen receptor with the regulatory subunit of Phosphatidylinositol–3-OH kinase
  1354. A direct interaction between oncogenic Ha-Ras and Phosphatidylinositol 3–kinase is not required for Ha-Ras-dependent transformation of epithelial cells
  1355. … IV Collagen Interacts with a Novel Binding Site on the β3Subunit of Integrin αvβ3 and Stimulates Focal Adhesion kinase and Phosphatidylinositol 3–kinase …
  1356. … 7, 8-tetrachlorodibenzo-p-dioxin (TCDD)-mediated aryl hydrocarbon receptor transformation and CYP1A1 induction by the Phosphatidylinositol 3–kinase inhibitor 2-(4 …
  1357. The protein-tyrosine kinase fer associates with signaling complexes containing insulin receptor substrate-1 and Phosphatidylinositol 3–kinase
  1358. Regulation of human neutrophil‐mediated cartilage proteoglycan degradation by Phosphatidylinositol‐3‐kinase
  1359. … of the C/EBP homologous protein (CHOP) by amino acid deprivation requires insulin-like growth factor I, Phosphatidylinositol 3–kinase, and mammalian target of …
  1360. Modulation of the basal activity of Phosphatidylinositol–3–kinase/protein kinase B signaling pathway in human hepatocarcinoma cells.
  1361. Cytokine-stimulated T cells induce macrophage IL-10 production dependent on Phosphatidylinositol 3–kinase and p70S6K: implications for rheumatoid …
  1362. Phosphatidylinositol 3–kinase in bovine lens and its stimulation by insulin and IGF-1
  1363. Insulin activation of mitogen-activated protein (MAP) kinase and Akt is Phosphatidylinositol 3–kinase-dependent in rat adipocytes
  1364. Inhibition of basophil histamine release by tyrosine kinase and Phosphatidylinositol 3–kinase inhibitors
  1365. Stimulation of glycogen synthesis by insulin requires S6 kinase and Phosphatidylinositol‐3‐kinase in HTC‐IR cells
  1366. Thrombin‐stimulated Phosphatidylinositol 3‐kinase activity in platelets is associated with activation of PYK2 tyrosine kinase: activation of both enzymes is aggregation …
  1367. HIV-Nef enhances interleukin-2 production and Phosphatidylinositol 3–kinase activity in a human T cell line
  1368. Exercise training prevents maturation-induced decreases in insulin receptor substrate-1 and Phosphatidylinositol 3–kinase in rat skeletal muscle
  1369. Involvement of both Phosphatidylinositol 3–kinase and p44/p42 mitogen-activated protein kinase pathways in the short-term regulation of pyruvate kinase L by insulin
  1370. Induction of Akt phosphorylation in rat primary astrocytes by H2O2 occurs upstream of Phosphatidylinositol 3–kinase: no evidence for oxidative inhibition of PTEN
  1371. Gene encoding the catalytic subunit p110beta of human Phosphatidylinositol 3–kinase: cloning, genomic structure, and screening for variants in patients with type 2 …
  1372. CD19 signal transduction in normal human B cells: linkage to downstream pathways requires Phosphatidylinositol 3‐kinase, protein kinase C and Ca2+
  1373. Activation of Phosphatidylinositol 3–kinase by oxidative stress leads to the induction of microsomal epoxide hydrolase in H4IIE cells
  1374. Direct identification of a major autophosphorylation site on vascular endothelial growth factor receptor Flt-1 that mediates Phosphatidylinositol 3′-kinase binding
  1375. Rap1 is a potent activation signal for leukocyte function-associated antigen 1 distinct from protein kinase C and Phosphatidylinositol–3-OH kinase
  1376. Phosphatidylinositol 3–kinase and protein kinase C contribute to the inhibition by interleukin 6 of phosphoenolpyruvate carboxykinase gene expression in cultured rat …
  1377. Protein tyrosine kinase‐dependent regulation of adenylate cyclase and Phosphatidylinositol 3‐kinase activates the expression of glial fibrillary acidic protein upon …
  1378. Odor-stimulated Phosphatidylinositol 3–kinase in lobster olfactory receptor cells
  1379. 3-Deoxy-3-substituted-D-myo-inositol imidazolyl ether lipid phosphates and carbonate as inhibitors of the Phosphatidylinositol 3–kinase pathway and cancer cell …
  1380. IL-10 inhibits apoptosis of promyeloid cells by activating insulin receptor substrate-2 and Phosphatidylinositol 3′-kinase
  1381. Roles of Phosphatidylinositol 3‐kinase and phospholipase D in temporal activation of superoxide production in FMLP‐stimulated human neutrophils
  1382. Association of Phosphatidylinositol 3–kinase with the insulin receptor: compartmentation in rat liver
  1383. Prolactin signaling to pim-1 expression: a role for Phosphatidylinositol 3–kinase
  1384. IGF-I stimulates chemotaxis of human neuroblasts. Involvement of type 1 IGF receptor, IGF binding proteins, Phosphatidylinositol–3 kinase pathway and plasmin …
  1385. Interleukin‐10 and interleukin‐13 inhibit proinflammatory cytokine‐induced ceramide production through the activation of Phosphatidylinositol 3‐kinase
  1386. Eicosanoid 12 (S)-HETE activates Phosphatidylinositol 3–kinase
  1387. … receptor (CR2, CD21) on human B lymphocyte surface triggers tyrosine phosphorylation of the 95-kDa nucleolin and its interaction with Phosphatidylinositol 3 kinase
  1388. Expression of Phosphatidylinositol–3 kinase in lung cancer
  1389. Ca2+-evoked serotonin secretion by parafollicular cells: roles in signal transduction of Phosphatidylinositol 3′-kinase, and the γ and ζ isoforms of protein kinase C
  1390. Activation of Phosphatidylinositol 3–kinase is required for transcriptional activity of F-type 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase: assessment of the …
  1391. Dynamin inhibits Phosphatidylinositol 3–kinase in hematopoietic cells
  1392. Evidence for the involvement of Phosphatidylinositol 3–kinase in fMLP-stimulated neutrophil adhesion to ICAM-1-transfected cells
  1393. CRKII participation in the cellular effects of growth hormone and insulin-like growth factor-1: Phosphatidylinositol–3 kinase dependent and independent effects
  1394. … library to identify basic residues in A-Raf required to mediate binding to the Src homology 2 domains of the p85 subunit of Phosphatidylinositol 3′-kinase
  1395. Structural organization of the mouse Phosphatidylinositol 3–kinase p110d gene
  1396. Involvement of tyrosine kinase and Phosphatidylinositol 3–kinase in phagocytosis by ascidian hemocytes
  1397. Phosphatidylinositol 3–kinase modulates IL-18-induced nuclear factor-kappa B activation.
  1398. … -induced glucose transport pathway in 3T3-L1 adipocytes is mediated by gab-1 and requires Gab-1-associated Phosphatidylinositol 3–kinase activity for full …
  1399. Protein kinase C and Phosphatidylinositol 3–kinase independently contribute to P-glycoprotein-mediated drug secretion in the mouse proximal tubule
  1400. Activation of NF-κB binding in HT-29 colon cancer cells by inhibition of Phosphatidylinositol 3–kinase
  1401. Involvement of sphingomyelinase in insulin‐induced Phosphatidylinositol 3‐kinase activation
  1402. Mitogenic signaling by cyclic adenosine monophosphate in chromaffin cells involves Phosphatidylinositol 3‐kinase activation
  1403. … induces eukaryotic initiation factor 4E-binding protein 1 phosphorylation via a Ca2+-dependent pathway independent of Phosphatidylinositol 3–kinase/Akt
  1404. … cascades initiated by fibroblast growth factor 1 on Xenopus oocytes expressing MDA-MB-231 mRNAs: role of Grb2, Phosphatidylinositol 3–kinase, Src tyrosine kinase …
  1405. Activation of phospholipase D in porcine tracheal smooth muscle: role of Phosphatidylinositol 3–kinase and RhoA activation
  1406. Role of the conserved acidic residue Asp21 in the structure of Phosphatidylinositol 3–kinase Src homology 3 domain: circular dichroism and nuclear magnetic …
  1407. Inhibition of Phosphatidylinositol 3–kinase does not alter forskolin-stimulated Cl− secretion by T84 cells
  1408. Modulation of the basal activity of N-acetylglucosaminyltransferase V by Phosphatidylinositol–3–kinase/protein kinase B signaling pathway in human hepatocarcinoma …
  1409. … of IGF-I on type 2 nitric oxide synthase expression in Ins-1 cells and protection against activation-dependent apoptosis: involvement of Phosphatidylinositol 3–kinase.
  1410. Regulation of the very late antigen‐4‐mediated adhesive activity of normal and nonreleaser basophils: roles for Src, Syk, and Phosphatidylinositol 3‐kinase
  1411. Phosphatidylinositol 3–kinase and prostaglandylinositol cyclic phosphate (cyclic PIP), a mediator of insulin action, in the signal transduction of insulin
  1412. Association of impaired Phosphatidylinositol 3–kinase activity in GLUT1-containing vesicles with malinsertion of glucose transporters into the plasma membrane of …
  1413. Interactions of Phosphatidylinositol 3‐kinase Src homology 3 domain with its ligand peptide studied by absorption, circular dichroism, and UV resonance Raman …
  1414. Cardiac insulin resistance is associated with an impaired recruitment of Phosphatidylinositol 3–kinase to GLUT4 vesicles.
  1415. Glucosamine enhances platelet-derived growth factor-induced DNA synthesis via Phosphatidylinositol 3–kinase pathway in rat aortic smooth muscle cells
  1416. Phosphatidylinositol‐3‐OH kinase regulatory subunits are differentially expressed during development of the rat cerebellum
  1417. Grb-2-Associated Binder-1 Is Involved in Insulin-Induced egr-1 Gene Expression through its Phosphatidylinositol 3′-kinase Binding Site
  1418. Identification of tyrosine residues involved in ligand recognition by the Phosphatidylinositol 3–kinase Src homology 3 domain: Circular dichroism and UV resonance …
  1419. Sensitizing effect of the Phosphatidylinositol 3–kinase inhibitor wortmannin on thermal neutron irradiation with or without boron compound.
  1420. Interleukin-1β Induced Synthesis of Protein kinase C-δ and Protein kinase C-ε in EL4 Thymoma Cells: Possible Involvement of Phosphatidylinositol 3–kinase
  1421. In cardiomyocyte hypoxia, insulin-like growth factor-I-induced antiapoptotic signaling requires Phosphatidylinositol–3-OH-kinase-dependent and mitogen-activated …
  1422. Ultrastructural modifications and Phosphatidylinositol–3–kinase expression and activity in myocardial tissue deriving from rats in different experimental conditions
  1423. Troglitazone Enhances Glucose Uptake Induced By α‐Adrenoceptor Stimulation Via Phosphatidylinositol 3‐kinase In Rat Heart
  1424. Involvement of regulating the Phosphatidylinositol 3–kinase signaling pathway in the process of herbimycin A-induced erythroid cell differentiation in the K562 …
  1425. Phosphatidylinositol 3–kinase regulates proliferation of RAW 264.7 macrophages
  1426. Regulation of cellular differentiation and cellular function by Phosphatidylinositol 3–kinase
  1427. Up-regulation of Phosphatidylinositol–3 kinase Signaling in plcg1 Gene Null Fibroblasts.
  1428. Tumor Necrosis Factor-α, Sphingomyelinase and Ceramides Activate Tyrosine kinase, P21ras and Phosphatidylinositol 3–kinase: Implications for Glucose Transport …
  1429. Arginine-specific ADP-ribosyltransferase on the surface of gizzard smooth muscle cells and the involvement of Phosphatidylinositol 3–kinase in maintaining the activity …
  1430. Casein kinase I associates with members of the centaurin-α family of Phosphatidylinositol 3, 4, 5-trisphosphate-binding proteins
  1431. Glucose-induced insulin resistance of Phosphatidylinositol 3′-OH kinase and AKT/PKB is mediated by the hexosamine biosynthesis pathway
  1432. TPO regulates Bcl-xL gene expression through Stat5 and Phosphatidylinositol–3–kinase activation pathways
  1433. Wortmannin, A Specific Phosphatidylinositol 3–kinase Inhibitor, Blocks In Vitro Fertilization and Embryonic Development of Bovine Oocytes Matured In Vitro with …
  1434. Activation of Phosphatidylinositol 3–kinase (PI3K) as a predictor of clinical outcome in breast cancer patients
  1435. Phosphatidylinositol 3–kinase and NF
  1436. The cloning and functional characterisation of murine Phosphatidylinositol 3–kinase gamma
  1437. Phosphatidylinositol 3–kinase is involved in IL-18-stimulated AP-1 activation
  1438. Investigation of Phosphatidylinositol–3–kinase (PI3K) and extracellular signal-regulated kinase 1/2 (ERK1/2) activation
  1439. A novel mechanism of regulation of Phosphatidylinositol 3–kinase: Tyrosine phosphorylation of p85 residue 688
  1440. A Role of Phosphatidylinositol 3–kinase (PI3K) on H-ras-lnduced Invasive phenotype
  1441. The role and regulation of Phosphatidylinositol–3 kinase, PTEN, and AKT in tumorigenesis
  1442. Rac and Phosphatidylinositol 3–kinase
  1443. A Role of Phosphatidylinositol 3–kinase (PI3K) on H-ras-Induced Invasive phenotype
  1444. The relationship of Met326Ile variant of p85? regulatory subunit of Phosphatidylinositol 3–kinase (PI3-K) with type 2 diabetes
  1445. Phosphatidylinositol 3-OH kinase–Akt/protein kinase B pathway mediates Gas6 induction of scavenger receptor a in immortalized human vascular smooth muscle cell …
  1446. Activation of Phosphatidylinositol 3–kinase (PI3K) is Required for Invasiveness and Motility in H-ras MCE10A Cells
  1447. The Role of Nuclear Factor kB and Phosphatidylinositol 3–kinase in Trypsinogen Activation in Cerulein-Stimulated Rat Pancreatic Acini
  1448. Phosphatidylinositol 3–kinase BUT NOT TUBERIN IS REQUIRED FOR PDGF-INDUCED CELL MIGRATION
  1449. THE ESSENTIAL ROLE OF Phosphatidylinositol 3–kinase IN THE INDUCTION OF MICROSOMAL EPOXIDE HYDROLASE
  1450. Role of Conserved Acidic Residue Asp21 in the Structure of Phosphatidylinositol 3–kinase Src Homology 3 Domain: Circular Dichroism and Nuclear Magnetic …
  1451. Retinoic acid inhibits transformation by modulating Phosphatidylinositol 3–kinase signaling to the nucleus
  1452. Regulation of hematopoietic cell proliferation by cytokine-activated Phosphatidylinositol 3–kinase
  1453. Involvement of Phosphatidylinositol 3–kinase in the Insulin Signaling in Preimplantation Mouse Embryos
  1454. Regulation of FRTL-5 thyroid cell growth by Phosphatidylinositol (OH) 3 kinase-dependent Akt-mediated signaling
  1455. Expression of Phosphatidylinositol 3–kinase during the proliferation of the hypoxic rat pulmonary arterial smooth muscle cells
  1456. Regulation of lysosomal pH in macrophages via Phosphatidylinositol 3–kinase and protein kinase C
  1457. Activation of Phosphatidylinositol 3–kinase-protein kinase B (PI3K-PKB) induced by 17?-estradiol in endometrial carcinoma cell (Ishikawa)
  1458. Cytokines Prevent Dexamethasone-induced Apoptosis via the Activation of Mitogen-activated Protein kinase and Phosphatidylinositol 3–kinase Pathways in a …
  1459. An Inhibitory Role of the Phosphatidylinositol 3–kinase-signaling Pathway in Vascular Endothelial Growth Factor-induced Tissue Factor Expression
  1460. c-CBL is the bridge molecule linking BCR/ABL to Phosphatidylinositol–3 kinase
  1461. Fas and ceramide inhibition of the Phosphatidylinositol–3–kinase (PI3K) cell survival pathway in human granulosa luteal cells (hGLC).
  1462. The Link between Insulin Resistance and Hyperinsulinemia: Inhibition of Phosphatidylinositol 3–kinase (PI3K) by Wortmannin Augments Glucose (G)-Induced Insulin …
  1463. Wortmannin, A Specific Phosphatidylinositol 3–kinase Inhibitor, Blocks In Vitro Fertilization and Embryonic Development of Bovine Oocytes Matured In Vitro with …
  1464. Lysophosphatidylcholine generates superoxide anions through activation of Phosphatidylinositol 3–kinase in human neutrophils
  1465. Coincident signaling of cAMP with Phosphatidylinositol 3‘kinase and mitogen-activated protein kinase signal transduction cascades: A role in regulating gene …
  1466. The role of nucleoside diphosphate kinase and Phosphatidylinositol 3–kinase in the expression and cellular localization of the glial fibrillary acidic protein …
  1467. Insulin Regulates Alternative Splicing of Protein kinase C ßII through a Phosphatidylinositol 3–kinase-dependent Pathway Involving the Nuclear Serine …
  1468. Evidence for Involvement of Gab-1 Associated Phosphatidylinositol 3–kinase in Osmotic Shock Induced Glucose Transport in 3T3-L1 Adipocytes
  1469. Human SMG-1, a novel Phosphatidylinositol 3–kinase-related protein kinase, associates with components of the mRNA surveillance complex and involved in the …
  1470. Aggretin, a C-Type Lectin Protein, Induces Platelet Aggregation Via Integrin 21 and Gpib in a Phosphatidylinositol 3–kinase Independent Pathway
  1471. Interleukin-1 receptor associated kinase 1 and Phosphatidylinositol 3 kinase regulate the NF-kappaB activation induced by IL-1
  1472. AtPIP5K1, an Arabidopsis thaliana Phosphatidylinositol phosphate kinase, synthesizes PtdIns (3, 4) P2 and PtdIns (4, 5) P2 in vitro and is inhibited by phosphorylation
  1473. Role of the Phosphatidylinositol (PI) 3–kinase/Akt protein kinase signaling pathway in the survival of rat sympathetic neurons
  1474. The Phosphatidylinositol 3–kinase–AKT pathway in human cancer
  1475. Leading the way: directional sensing through Phosphatidylinositol 3–kinase and other signaling pathways
  1476. Prostanoid receptors and Phosphatidylinositol 3–kinase: a pathway to cancer?
  1477. Analysis of the Phosphatidylinositol 3′-kinase Signaling Pathway in Glioblastoma Patients in Vivo
  1478. A crucial role for the p110δ subunit of Phosphatidylinositol 3–kinase in B cell development and activation
  1479. Phosphatidylinositol–3 kinase inhibitors enhance the anti-leukemia effect of STI571
  1480. The Phosphatidylinositol 3–kinase, p38, and extracellular signal-regulated kinase pathways are involved in osteoclast differentiation
  1481. Rapid accumulation of Akt in mitochondria following Phosphatidylinositol 3‐kinase activation
  1482. Inhibition of Phosphatidylinositol 3–kinase enhances mitogenic actions of insulin in endothelial cells
  1483. The Phosphatidylinositol 3–kinase (PI3K)-Akt pathway suppresses Bax translocation to mitochondria
  1484. Role of the Phosphatidylinositol 3–kinase/Akt and mTOR/P70S6-kinase pathways in the proliferation and apoptosis in multiple myeloma
  1485. Role of the Phosphatidylinositol 3 kinase-Akt pathway in the regulation of IL-10 and IL-12 by Porphyromonas gingivalis lipopolysaccharide
  1486. Anti-cancer alkyl-lysophospholipids inhibit the Phosphatidylinositol 3–kinase–Akt/PKB survival pathway
  1487. The Phosphatidylinositol 3–kinase-Akt pathway limits lipopolysaccharide activation of signaling pathways and expression of inflammatory mediators in human …
  1488. Inhibition of Phosphatidylinositol 3′-kinase Increases Efficacy of Paclitaxel in in Vitro and in Vivo Ovarian Cancer Models
  1489. Phosphatidylinositol 3–kinase/Akt signaling in the response of vascular endothelium to ionizing radiation
  1490. Role of the Phosphatidylinositol 3′-kinase/PTEN/Akt kinase pathway in the overexpression of fatty acid synthase in LNCaP prostate cancer cells
  1491. Receptor-specific regulation of Phosphatidylinositol 3′-kinase activation by the protein tyrosine phosphatase Shp2
  1492. A Phosphatidylinositol 3–kinase–phosphodiesterase 3B–cyclic AMP pathway in hypothalamic action of leptin on feeding
  1493. Phosphatidylinositol 3‐kinase is involved in Toll‐like receptor 4‐mediated cytokine expression in mouse macrophages
  1494. Src kinase mediates Phosphatidylinositol 3–kinase/Akt-dependent rapid endothelial nitric-oxide synthase activation by estrogen
  1495. The role of focal adhesion kinase–Phosphatidylinositol 3–kinase-akt signaling in hepatic stellate cell proliferation and type I collagen expression
  1496. Inhibition of the Phosphatidylinositol 3′-kinase-AKT Pathway Induces Apoptosis in Pancreatic Carcinoma Cells in Vitro and in Vivo
  1497. Phosphatidylinositol 3–kinase mediates proliferative signals in intestinal epithelial cells
  1498. Phosphatidylinositol 3–kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin
  1499. Role of Phosphatidylinositol 3–kinase in oxidative stress-induced disruption of tight junctions
  1500. Targeting the Phosphatidylinositol 3–kinase/Akt pathway for enhancing breast cancer cells to radiotherapy
  1501. Phosphorylation of glycogen synthase kinase–3β during preconditioning through a Phosphatidylinositol–3–kinase–dependent pathway is cardioprotective
  1502. Activation of fatty acid synthesis during neoplastic transformation: role of mitogen-activated protein kinase and Phosphatidylinositol 3–kinase
  1503. Human mammary epithelial cell transformation through the activation of Phosphatidylinositol 3–kinase
  1504. Phosphatidylinositol 3–kinase regulates the induction of long-term potentiation through extracellular signal-related kinase-independent mechanisms
  1505. Regulation of hypoxia-inducible factor-1α protein level during hypoxic conditions by the Phosphatidylinositol 3–kinase/Akt/glycogen synthase kinase 3β …
  1506. Role of translation initiation factor 2B in control of cell survival by the Phosphatidylinositol 3–kinase/Akt/glycogen synthase kinase 3β signaling pathway
  1507. Constitutively activated Phosphatidylinositol–3 kinase (PI-3K) is involved in the defect of apoptosis in B-CLL: association with protein kinase Cδ
  1508. Activation of the Phosphatidylinositol 3–kinase/protein kinase Akt pathway mediates nitric oxide-induced endothelial cell migration and angiogenesis
  1509. Involvement of protein kinase C and Phosphatidylinositol 3–kinase pathways in the survival of B-cell chronic lymphocytic leukemia cells
  1510. Phosphatidylinositol 3–kinase/Akt stimulates androgen pathway through GSK3β inhibition and nuclear β-catenin accumulation
  1511. Suppression versus induction of androgen receptor functions by the Phosphatidylinositol 3–kinase/Akt pathway in prostate cancer LNCaP cells with different …
  1512. Mutant epidermal growth factor receptor signaling down-regulates p27 through activation of the Phosphatidylinositol 3–kinase/Akt pathway in glioblastomas
  1513. Normoxic induction of the hypoxia-inducible factor 1α by insulin and interleukin-1β involves the Phosphatidylinositol 3–kinase pathway
  1514. Effects of deguelin on the Phosphatidylinositol 3–kinase/Akt pathway and apoptosis in premalignant human bronchial epithelial cells
  1515. Native group‐III metabotropic glutamate receptors are coupled to the mitogen‐activated protein kinase/Phosphatidylinositol‐3‐kinase pathways
  1516. … factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and Phosphatidylinositol 3–kinase signaling in colon …
  1517. Phosphatidylinositol 3–kinase Functionally Compartmentalizes the Concurrent Gs Signaling During β2-Adrenergic Stimulation
  1518. Modulation of Rab5 and Rab7 recruitment to phagosomes by Phosphatidylinositol 3–kinase
  1519. Immunocytochemical detection of Phosphatidylinositol 3–kinase activation by insulin and leptin
  1520. Activation of Phosphatidylinositol 3–kinase/Akt pathway by androgen through interaction of p85α, androgen receptor, and Src
  1521. The endothelial receptor tyrosine kinase Tie1 activates Phosphatidylinositol 3–kinase and Akt to inhibit apoptosis
  1522. Phosphatidylinositol 3–kinase interacts with the adaptor protein Dab1 in response to Reelin signaling and is required for normal cortical lamination
  1523. Phosphatidylinositol 3–kinase: a molecule mediating BDNF-dependent spatial memory formation
  1524. Phosphatidylinositol 3–kinase regulates nuclear translocation of NF-E2-related factor 2 through actin rearrangement in response to oxidative stress
  1525. Endurance training improves responsiveness to insulin and modulates insulin signal transduction through the Phosphatidylinositol 3–kinase/Akt-1 pathway
  1526. Activation of the Phosphatidylinositol 3–kinase/Akt signaling pathway by retinoic acid is required for neural differentiation of SH-SY5Y human neuroblastoma …
  1527. Inhibition of Phosphatidylinositol 3–kinase-Akt signaling blocks growth, promotes apoptosis, and enhances sensitivity of small cell lung cancer cells to chemotherapy
  1528. Src family protein-tyrosine kinases alter the function of PTEN to regulate Phosphatidylinositol 3–kinase/AKT cascades
  1529. Herceptin-induced inhibition of Phosphatidylinositol–3 kinase and Akt Is required for antibody-mediated effects on p27, cyclin D1, and antitumor action
  1530. Microphthalmia associated transcription factor is a target of the Phosphatidylinositol–3–kinase pathway
  1531. Cannabinoids promote oligodendrocyte progenitor survival: involvement of cannabinoid receptors and Phosphatidylinositol–3 kinase/Akt signaling
  1532. E-cadherin homophilic ligation directly signals through Rac and Phosphatidylinositol 3–kinase to regulate adhesive contacts
  1533. Phosphatidylinositol 3–kinase is required for the expression but not for the induction or the maintenance of long-term potentiation in the hippocampal CA1 region
  1534. Early expression of myocardial HIF-1α in response to mechanical stresses: regulation by stretch-activated channels and the Phosphatidylinositol 3–kinase signaling …
  1535. Phosphatidylinositol 3–kinase/Akt signaling is neither required for hypoxic stabilization of HIF-1α nor sufficient for HIF-1-dependent target gene transcription
  1536. Phosphatidylinositol 3–kinase redistribution is associated with skeletal muscle insulin resistance in gestational diabetes mellitus
  1537. Phosphatidylinositol 3‐kinase is a central mediator of NMDA receptor signalling to MAP kinase (Erk1/2), Akt/PKB and CREB in striatal neurones
  1538. Genomic copy number analysis of non-small cell lung cancer using array comparative genomic hybridization: implications of the Phosphatidylinositol 3–kinase …
  1539. Requirement of BMP-2-induced Phosphatidylinositol 3–kinase and Akt serine/threonine kinase in osteoblast differentiation and Smad-dependent BMP-2 gene …
  1540. Phosphatidylinositol 3–kinase regulates the CD4/CD8 T cell differentiation ratio
  1541. Endocytosed transferrin receptors recycle via distinct dynamin and Phosphatidylinositol 3–kinase-dependent pathways
  1542. Insulin activation of Phosphatidylinositol 3–kinase in the hypothalamic arcuate nucleus: a key mediator of insulin-induced anorexia
  1543. Regulation of TRAIL expression by the Phosphatidylinositol 3–kinase/Akt/GSK-3 pathway in human colon cancer cells
  1544. RANKL regulates endothelial cell survival through the Phosphatidylinositol 3′‐kinase/Akt signal transduction pathway
  1545. Characterization of the Met326Ile variant of Phosphatidylinositol 3–kinase p85α
  1546. Caveolin-induced activation of the Phosphatidylinositol 3–kinase/Akt pathway increases arsenite cytotoxicity
  1547. Protective effect of dopamine D2 agonists in cortical neurons via the Phosphatidylinositol 3 kinase cascade
  1548. Regulation of rat Sertoli cell function by FSH: possible role of Phosphatidylinositol 3–kinase/protein kinase B pathway
  1549. Protective effects of docosahexaenoic acid in staurosporine‐induced apoptosis: involvement of Phosphatidylinositol‐3 kinase pathway
  1550. Respiratory syncytial virus inhibits apoptosis and induces NF-κB activity through a Phosphatidylinositol 3–kinase-dependent pathway
  1551. Role of the Phosphatidylinositol 3′-kinase/PTEN/Akt kinase pathway in tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in non-small cell …
  1552. Aldosterone regulates vascular reactivity: short-term effects mediated by Phosphatidylinositol 3–kinase–dependent nitric oxide synthase activation
  1553. ERK negatively regulates the epidermal growth factor-mediated interaction of Gab1 and the Phosphatidylinositol 3–kinase
  1554. Vanadate-induced expression of hypoxia-inducible factor 1α and vascular endothelial growth factor through Phosphatidylinositol 3–kinase/Akt pathway and …
  1555. Eph B4 receptor signaling mediates endothelial cell migration and proliferation via the Phosphatidylinositol 3–kinase pathway
  1556. Critical involvement of the Phosphatidylinositol 3–kinase/Akt pathway in anchorage-independent growth and hematogeneous intrahepatic metastasis of liver cancer
  1557. Cannabinoids protect astrocytes from ceramide-induced apoptosis through the Phosphatidylinositol 3–kinase/protein kinase B pathway
  1558. Molecular basis of cell membrane estrogen receptor interaction with Phosphatidylinositol 3–kinase in endothelial cells
  1559. … lethal effects of pharmacological cyclin-dependent kinase inhibitors in human leukemia cells proceed through a Phosphatidylinositol 3–kinase/Akt-dependent process
  1560. Kaposi’s sarcoma-associated herpesvirus induces the Phosphatidylinositol 3–kinase-PKC-ζ-MEK-ERK signaling pathway in target cells early during infection …
  1561. C5a delays apoptosis of human neutrophils by a Phosphatidylinositol 3–kinase-signaling pathway
  1562. Phosphatidylinositol 3–kinase activity negatively regulates stability of cyclooxygenase 2 mRNA
  1563. CD40 induces human multiple myeloma cell migration via Phosphatidylinositol 3–kinase/AKT/NF-κB signaling
  1564. Ras mediates radioresistance through both Phosphatidylinositol 3–kinase-dependent and Raf-dependent but mitogen-activated protein kinase/extracellular signal …
  1565. β1 integrin regulates fibroblast viability during collagen matrix contraction through a Phosphatidylinositol 3–kinase/Akt/protein kinase B signaling pathway
  1566. … growth factor-induced migration of multiple myeloma cells is associated with β1 integrin-and Phosphatidylinositol 3–kinase-dependent PKCα activation
  1567. Activated Gαq inhibits p110α Phosphatidylinositol 3–kinase and Akt
  1568. Regulation of Fas expression by STAT3 and c-Jun is mediated by Phosphatidylinositol 3–kinase-AKT signaling
  1569. Ureteric bud outgrowth in response to RET activation is mediated by Phosphatidylinositol 3–kinase
  1570. … tumor cells can be overcome through restoration of PTEN function or pharmacologic modulation of constitutive Phosphatidylinositol 3′-kinase/Akt pathway signaling
  1571. The role of Phosphatidylinositol 3‐kinase in neural cell adhesion molecule‐mediated neuronal differentiation and survival
  1572. Reduced activation of Phosphatidylinositol–3 kinase and increased serine 636 phosphorylation of insulin receptor substrate-1 in primary culture of skeletal muscle …
  1573. IL-12 provides proliferation and survival signals to murine CD4+ T cells through Phosphatidylinositol 3–kinase/Akt signaling pathway
  1574. Regulation of Phosphatidylinositol 3–kinase activity and Phosphatidylinositol 3, 4, 5-trisphosphate accumulation by neutrophil priming agents
  1575. Implication of Phosphatidylinositol 3–kinase membrane recruitment in hydrogen peroxide-induced activation of PI3K and Akt
  1576. Phosphatidylinositol 3–kinase controls human intestinal epithelial cell differentiation by promoting adherens junction assembly and p38 MAPK activation
  1577. Phosphatidylinositol 3–kinase Regulates Human Immunodeficiency Virus Type 1 Replication following Viral Entry in Primary CD4+ T Lymphocytes and Macrophages
  1578. CD40-dependent activation of Phosphatidylinositol 3–kinase/Akt pathway mediates endothelial cell survival and in vitro angiogenesis
  1579. The phospholipase Cγ1-dependent pathway of FcϵRI-mediated mast cell activation is regulated independently of Phosphatidylinositol 3–kinase
  1580. Subversion of cell signaling pathways by hepatitis C virus nonstructural 5A protein via interaction with Grb2 and P85 Phosphatidylinositol 3–kinase
  1581. IKKβ and Phosphatidylinositol 3–kinase/Akt participate in non-pathogenic Gram-negative enteric bacteria-induced RelA phosphorylation and NF-κB activation …
  1582. The Phosphatidylinositol 3‐kinase inhibitor LY294002 potently blocks Kv currents via a direct mechanism
  1583. Transduction of growth or mitogenic signals into translational activation of TOP mRNAs is fully reliant on the Phosphatidylinositol 3–kinase-mediated pathway but …
  1584. … cell motility and nuclear factor κB-mediated secretion of urokinase type plasminogen activator through Phosphatidylinositol 3–kinase/Akt signaling pathways …
  1585. Expression of a mutated form of the p85α regulatory subunit of Phosphatidylinositol 3–kinase in a Hodgkin’s lymphoma-derived cell line (CO)
  1586. Brain-derived neurotrophic factor activation of TrkB protects neuroblastoma cells from chemotherapy-induced apoptosis via Phosphatidylinositol 3′-kinase pathway
  1587. … of HER2 by ansamycins induces growth arrest and apoptosis in cells with HER2 overexpression via a HER3, Phosphatidylinositol 3′-kinase-AKT-dependent pathway
  1588. … gene inactivation in mantle cell lymphoma mainly occurs by truncating mutations and missense mutations involving the Phosphatidylinositol–3 kinase domain and is …
  1589. Inactivation of the antiapoptotic Phosphatidylinositol 3–kinase-Akt pathway by the combined treatment of taxol and mitogen-activated protein kinase kinase inhibition
  1590. … -1 protects human breast epithelial cells against intrinsic apoptotic cell death via the focal adhesion kinase/Phosphatidylinositol 3–kinase and MAPK signaling …
  1591. Phosphatidylinositol 3‐kinase coordinately activates the MEK/ERK and AKT/NFκB pathways to maintain osteoclast survival
  1592. Negative regulation of Phosphatidylinositol 3–kinase and Akt signalling pathway by PKC
  1593. The role of Phosphatidylinositol 3–kinase, rho family GTPases, and STAT3 in Ros-induced cell transformation
  1594. Dysregulation of Phosphatidylinositol 3‐kinase and downstream effectors in human breast cancer
  1595. Insulin down-regulates insulin receptor substrate-2 expression through the Phosphatidylinositol 3–kinase/Akt pathway
  1596. Reciprocal modulation of Toll-like receptor-4 signaling pathways involving MyD88 and Phosphatidylinositol 3–kinase/AKT by saturated and polyunsaturated …
  1597. Estrogen receptor alpha forms estrogen-dependent multimolecular complexes with insulin-like growth factor receptor and Phosphatidylinositol 3–kinase in the adult rat …
  1598. Androgens stimulate hypoxia-inducible factor 1 activation via autocrine loop of tyrosine kinase receptor/Phosphatidylinositol 3′-kinase/protein kinase B in prostate …
  1599. A Phosphatidylinositol 3–kinase-independent insulin signaling pathway to N-WASP/Arp2/3/F-actin required for GLUT4 glucose transporter recycling
  1600. Hepatocyte growth factor induced human trophoblast motility involves Phosphatidylinositol–3–kinase, mitogen-activated protein kinase, and inducible nitric oxide …
  1601. Evidence that SHIP-1 contributes to Phosphatidylinositol 3, 4, 5-trisphosphate metabolism in T lymphocytes and can regulate novel phosphoinositide 3–kinase …
  1602. Insulin-like growth factor-I inhibits progesterone receptor expression in breast cancer cells via the Phosphatidylinositol 3–kinase/Akt/mammalian target of rapamycin …
  1603. … hormone-treated astrocytes is mediated by epidermal growth factor/mitogen-activated protein kinase–Phosphatidylinositol 3–kinase pathways and involves …
  1604. Cyclin-dependent kinase-5 is involved in neuregulin-dependent activation of Phosphatidylinositol 3–kinase and Akt activity mediating neuronal survival
  1605. Interaction between Nef and Phosphatidylinositol–3–kinase leads to activation of p21-activated kinase and increased production of HIV
  1606. Potential role of Phosphatidylinositol 3 kinase, rather than DNA-dependent protein kinase, in CpG DNA–induced immune activation
  1607. p38 Mitogen‐activated protein kinase and Phosphatidylinositol 3‐kinase activities have opposite effects on human neutrophil apoptosis
  1608. Activation of Phosphatidylinositol 3–kinase is important for erythropoietin-induced erythropoiesis from CD34+ hematopoietic progenitor cells
  1609. PTEN and Phosphatidylinositol 3′-kinase inhibitors up-regulate p53 and block tumor-induced angiogenesis: evidence for an effect on the tumor and endothelial …
  1610. Phosphatidylinositol 3–kinase and NF-κB regulate motility of invasive MDA-MB-231 human breast cancer cells by the secretion of urokinase-type plasminogen …
  1611. The Role of Novel Oncogenes Squamous Cell Carcinoma-related Oncogene and Phosphatidylinositol 3–kinase p110α in Squamous Cell Carcinoma of the Oral …
  1612. Signal transduction from N-cadherin increases Bcl-2: regulation of the Phosphatidylinositol 3–kinase/Akt pathway by homophilic adhesion and actin …
  1613. Thrombopoietin regulates Bcl-xL gene expression through Stat5 and Phosphatidylinositol 3–kinase activation pathways
  1614. Parallel Phosphatidylinositol–3 kinase and p42/44 mitogen-activated protein kinase signaling pathways subserve the mitogenic and antiapoptotic actions of insulin-like …
  1615. CD28 and inducible costimulatory protein Src homology 2 binding domains show distinct regulation of Phosphatidylinositol 3–kinase, Bcl-xL, and IL-2 expression in …
  1616. TAPP1 and TAPP2 are targets of Phosphatidylinositol 3–kinase signaling in B cells: sustained plasma membrane recruitment triggered by the B-cell antigen receptor
  1617. Evidence that rheumatoid arthritis synovial T cells are similar to cytokine‐activated T cells: involvement of Phosphatidylinositol 3‐kinase and nuclear factor κB …
  1618. Epstein-Barr virus latent membrane protein 1 (LMP1) activates the Phosphatidylinositol 3–kinase/Akt pathway to promote cell survival and induce actin filament …
  1619. Ephrin-B2 induces migration of endothelial cells through the Phosphatidylinositol–3 kinase pathway and promotes angiogenesis in adult vasculature
  1620. Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated Phosphatidylinositol 3–kinase activity in muscle
  1621. Insulin-like growth factor-1 induces adhesion and migration in human multiple myeloma cells via activation of β1-integrin and Phosphatidylinositol 3′-kinase/AKT …
  1622. Grb10 inhibits insulin-stimulated insulin receptor substrate (IRS)-Phosphatidylinositol 3–kinase/Akt signaling pathway by disrupting the association of IRS-1 …
  1623. Synchronous activation of ERK and Phosphatidylinositol 3–kinase pathways is required for collagen and extracellular matrix production in keloids
  1624. EGF receptor mediates adhesion-dependent activation of the Rac GTPase: a role for Phosphatidylinositol 3–kinase and Vav2
  1625. Epidermal growth factor receptor-dependent, NF-κB-independent activation of the Phosphatidylinositol 3–kinase/Akt pathway inhibits ultraviolet irradiation …
  1626. Sustained Production of H2O2Activates Pro-matrix Metalloproteinase-2 through Receptor Tyrosine kinases/Phosphatidylinositol 3–kinase/NF-κB Pathway
  1627. Insulin stimulates hypoxia-inducible factor 1 through a Phosphatidylinositol 3–kinase/target of rapamycin-dependent signaling pathway
  1628. Insulin-like growth factor-I inhibits transcriptional responses of transforming growth factor-β by Phosphatidylinositol 3–kinase/Akt-dependent suppression of the …
  1629. … lucidum inhibits spontaneous and Fas‐mediated apoptosis in human neutrophils through activation of the Phosphatidylinositol 3 kinase/Akt signaling pathway
  1630. Phosphatidylinositol 3 kinase regulates synapse specificity of hippocampal long-term depression
  1631. Phosphatidylinositol–3–kinase–Akt kinase and p42/p44 mitogen-activated protein kinases mediate neurotrophic and excitoprotective actions of a secreted form of …
  1632. … induces an autocrine‐paracrine survival pathway via platelet‐derived growth factor (PDGF)‐B/PDGF‐β receptor/Phosphatidylinositol 3‐kinase/Akt signaling in RN46A …
  1633. Characterization of Phosphatidylinositol 3–kinase-dependent phosphorylation of the hydrophobic motif site Thr389 in p70 S6 kinase 1
  1634. Insulin-Like Growth Factor-1–Induced Phosphorylation of Transcription Factor FKHRL1 Is Mediated by Phosphatidylinositol 3–kinase/Akt kinase and Role of This …
  1635. Selective PDZ protein-dependent stimulation of Phosphatidylinositol 3–kinase by the adenovirus E4-ORF1 oncoprotein
  1636. … endothelial growth factor induces protein kinase C (PKC)-dependent Akt/PKB activation and Phosphatidylinositol 3′-kinase-mediated PKCδ phosphorylation: role of …
  1637. Augmentation of sodium butyrate-induced apoptosis by Phosphatidylinositol 3′-kinase inhibition in the KM20 human colon cancer cell line
  1638. Phosphatidylinositol 3–kinase regulates PMA-induced differentiation and superoxide production in HL-60 cells
  1639. … of FcϵRI‐and FcγRI‐mediated degranulation and TNF‐α synthesis in human mast cells: selective utilization of Phosphatidylinositol‐3‐kinase for FcγRI‐induced …
  1640. The oncogene Phosphatidylinositol 3′-kinase catalytic subunit α promotes angiogenesis via vascular endothelial growth factor in ovarian carcinoma
  1641. Tauroursodeoxycholic acid prevents amyloid-β peptide-induced neuronal death via a Phosphatidylinositol 3–kinase-dependent signaling pathway
  1642. Functional cooperation among Ras, STAT5, and Phosphatidylinositol 3–kinase is required for full oncogenic activities of BCR/ABL in K562 cells
  1643. … expression of the hypoxia marker MN/carbonic anhydrase IX in the absence of hypoxia-inducible factor 1α stabilization: a role for Phosphatidylinositol 3′-kinase
  1644. Involvement of Phosphatidylinositol 3–kinase γ in neutrophil apoptosis
  1645. Activation of Phosphatidylinositol 3–kinase contributes to insulin-like growth factor I-mediated inhibition of pancreatic β-cell death
  1646. Inhibition of net HepG2 cell apolipoprotein B secretion by the citrus flavonoid naringenin involves activation of Phosphatidylinositol 3–kinase, independent of insulin …
  1647. The Phosphatidylinositol 3–kinase/Akt signaling pathway modulates the endocrine differentiation of trophoblast cells
  1648. Src and Phosphatidylinositol 3–kinase mediate soluble E-selectin–induced angiogenesis
  1649. Dietary cod protein restores insulin-induced activation of Phosphatidylinositol 3–kinase/Akt and GLUT4 translocation to the T-tubules in skeletal muscle of high-fat-fed …
  1650. Phosphatidylinositol 3–kinase but not tuberin is required for PDGF-induced cell migration
  1651. Inhibition of Phosphatidylinositol 3–kinase sensitizes vascular endothelial cells to cytokine-initiated cathepsin-dependent apoptosis
  1652. The growth arrest-specific gene product Gas6 promotes the survival of human oligodendrocytes via a Phosphatidylinositol 3–kinase-dependent pathway
  1653. Macrophage-colony-stimulating factor-induced activation of extracellular-regulated kinase involves Phosphatidylinositol 3–kinase and reactive oxygen species in …
  1654. The in Vitro and in Vivo Effects of 2-(4-Morpholinyl)-8-phenyl-chromone (LY294002), a Specific Inhibitor of Phosphatidylinositol 3′-kinase, in Human Colon Cancer …
  1655. Essential Role of Phosphatidylinositol 3–kinase-Dependent CCAAT/Enhancer Binding Protein β Activation in the Induction of Glutathione S-Transferase by Oltipraz
  1656. Betacellulin induces angiogenesis through activation of mitogen‐activated protein kinase and Phosphatidylinositol 3‘‐kinase in endothelial cells
  1657. Oncogenic H-Ras Enhances DNA Repair through the Ras/Phosphatidylinositol 3–kinase/Rac1 Pathway in NIH3T3 Cells: Evidence for association with …
  1658. Evidence for Phosphatidylinositol 3–kinase—Akt—p70S6K pathway activation and transduction of mitogenic signals by platelet-derived growth factor in human …
  1659. Laminin-10/11 and fibronectin differentially prevent apoptosis induced by serum removal via Phosphatidylinositol 3–kinase/Akt-and MEK1/ERK-dependent …
  1660. The Neuron-Specific Rai (ShcC) Adaptor Protein Inhibits Apoptosis by Coupling Ret to the Phosphatidylinositol 3–kinase/Akt Signaling Pathway
  1661. … expression of early growth response factor-1 by EP4, but not EP2, prostanoid receptors via the Phosphatidylinositol 3–kinase and extracellular signal …
  1662. Phosphatidylinositol 3–kinase Suppresses Glucose-Stimulated Insulin Secretion by Affecting Post-Cytosolic [Ca2+] Elevation Signals
  1663. Requirement for Phosphatidylinositol–3 kinase activity during progression through S-phase and entry into mitosis
  1664. Bile acid depletion and repletion regulate cholangiocyte growth and secretion by a Phosphatidylinositol 3–kinase–dependent pathway in rats
  1665. The effects of lidocaine on the activity of glutamate transporter EAAT3: the role of protein kinase C and Phosphatidylinositol 3–kinase
  1666. β-Arrestin1 mediates insulin-like growth factor 1 (IGF-1) activation of Phosphatidylinositol 3–kinase (PI3K) and anti-apoptosis
  1667. Phosphatidylinositol 3–kinase, protein kinase C, and MEK1/2 kinase regulation of dopamine transporters (DAT) require N-terminal DAT phosphoacceptor sites
  1668. Tumor necrosis factor alpha-induced interleukin-8 production via NF-κB and Phosphatidylinositol 3–kinase/Akt pathways inhibits cell apoptosis in human hepatocytes
  1669. IL-13-induced changes in the goblet cell density of human bronchial epithelial cell cultures: MAP kinase and Phosphatidylinositol 3–kinase regulation
  1670. … -cytokine cross-talk: the ELR+ CXC chemokine LIX (CXCl5) amplifies a proinflammatory cytokine response via a Phosphatidylinositol 3–kinase-NF-κB pathway
  1671. Activation of vascular endothelial growth factor receptor-1 sustains angiogenesis and Bcl-2 expression via the Phosphatidylinositol 3–kinase pathway in endothelial …
  1672. Nerve growth factor signals through TrkA, Phosphatidylinositol 3–kinase, and Rac1 to inactivate RhoA during the initiation of neuronal differentiation of PC12 …
  1673. Semaphorin 3F antagonizes neurotrophin-induced Phosphatidylinositol 3–kinase and mitogen-activated protein kinase kinase signaling: a mechanism for growth cone …
  1674. Phosphatidylinositol 3–kinase: a key regulator of vascular tone?
  1675. Estrogen regulation of c-fos gene expression through Phosphatidylinositol–3–kinase-dependent activation of serum response factor in MCF-7 breast cancer cells
  1676. Synapsin I-associated Phosphatidylinositol 3–kinase mediates synaptic vesicle delivery to the readily releasable pool
  1677. Putative Phosphatidylinositol 3–kinase (PI3K) binding motifs in ovine betaretrovirus Env proteins are not essential for rodent fibroblast transformation and PI3K/Akt …
  1678. Phosphatidylinositol 3–kinase is essential for the proliferation of lymphoblastoid cells
  1679. Taurolithocholic acid exerts cholestatic effects via Phosphatidylinositol 3–kinase-dependent mechanisms in perfused rat livers and rat hepatocyte couplets
  1680. The Phosphatidylinositol‐3 kinase (PI3K)‐Akt pathway suppresses neurite branch formation in NGF‐treated PC12 cells
  1681. Involvement of Phosphatidylinositol 3–kinase, but not RalGDS, in TC21/R-Ras2-mediated transformation
  1682. Interferon beta promotes survival in primary astrocytes through Phosphatidylinositol 3–kinase
  1683. Role of Phosphatidylinositol 3–kinase/Akt pathway in angiotensin II and insulin-like growth factor-1 modulation of nitric oxide synthase in vascular smooth muscle cells
  1684. Acetylcholine leads to free radical production dependent on KATP channels, Gi proteins, Phosphatidylinositol 3–kinase and tyrosine kinase
  1685. Hepatitis B virus X protein activates a survival signaling by linking SRC to Phosphatidylinositol 3–kinase
  1686. … sugar absorption is regulated by phosphorylation and turnover of protein kinase C βII mediated by Phosphatidylinositol 3–kinase-and mammalian target of …
  1687. The α5β1 integrin selectively enhances epidermal growth factor signaling to the Phosphatidylinositol–3–kinase/Akt pathway in intestinal epithelial cells
  1688. Src mediates prolactin-dependent proliferation of T47D and MCF7 cells via the activation of focal adhesion kinase/Erk1/2 and Phosphatidylinositol 3–kinase pathways
  1689. Phosphatidylinositol 3–kinase and calcium-activated transcription pathways are required for VLDL-induced smooth muscle cell proliferation
  1690. Estrogen enhances depolarization-induced glutamate release through activation of Phosphatidylinositol 3–kinase and mitogen-activated protein kinase in cultured …
  1691. Regulatory role for SRC and Phosphatidylinositol 3–kinase in initiation of fibronectin matrix assembly
  1692. TC21 mediates transformation and cell survival via activation of Phosphatidylinositol 3–kinase/Akt and NF-κB signaling pathway
  1693. … CD44 interaction with RhoGEF and Rho kinase promotes Grb2-associated binder-1 phosphorylation and Phosphatidylinositol 3–kinase signaling leading to …
  1694. Necessary role of Phosphatidylinositol 3‐kinase in transforming growth factor β–mediated activation of Akt in normal and rheumatoid arthritis synovial fibroblasts
  1695. … motility and nuclear factor κB-mediated secretion of urokinase type plasminogen activator by inhibiting the Phosphatidylinositol 3′-kinase activity in breast …
  1696. Attenuated 5‐HT1A receptor signaling in brains of suicide victims: involvement of adenylyl cyclase, Phosphatidylinositol 3‐kinase, Akt and mitogen‐activated protein …
  1697. … nitric-oxide synthase by tumor necrosis factor-α: a novel pathway involving sequential activation of neutral sphingomyelinase, Phosphatidylinositol–3′ kinase, and …
  1698. … cell line via a novel nongenomic mechanism involving the glucocorticoid receptor, protein kinase C, Phosphatidylinositol 3–kinase, and mitogen-activated protein …
  1699. Phosphatidylinositol 3–kinase is a key regulator of early phase differentiation in keratinocytes
  1700. Activation of Protein kinase C-ζ by Insulin and Phosphatidylinositol–3,4,5-(PO4)3 Is Defective in Muscle in Type 2 Diabetes and Impaired Glucose Tolerance …
  1701. Evidence that Phosphatidylinositol 3–kinase-and mitogen-activated protein kinase kinase-4/c-Jun NH2-terminal kinase-dependent pathways cooperate to …
  1702. Interleukin-3-mediated cell survival signals include Phosphatidylinositol 3–kinase-dependent translocation of the glucose transporter GLUT1 to the cell surface
  1703. … growth factor I-mediated protection from rapamycin-induced apoptosis is independent of Ras-Erk1-Erk2 and Phosphatidylinositol 3′-kinase-Akt signaling pathways
  1704. Requirement of Phosphatidylinositol 3–kinase activation and calcium influx for leukotriene B4-induced enzyme release
  1705. Studies of the mitogen-activated protein kinases and Phosphatidylinositol–3 kinase in the lens. 1. The mitogenic and stress responses
  1706. The cross-talk between angiotensin and insulin differentially affects Phosphatidylinositol 3–kinase-and mitogen-activated protein kinase-mediated signaling in rat heart …
  1707. Impaired insulin action on Phosphatidylinositol 3–kinase activity and glucose transport in skeletal muscle of pancreatic cancer patients
  1708. Etk/Bmx transactivates vascular endothelial growth factor 2 and recruits Phosphatidylinositol 3–kinase to mediate the tumor necrosis factor-induced angiogenic …
  1709. Phosphatidylinositol 3′-kinase is required for growth of mast cells expressing the kit catalytic domain mutant
  1710. Cell cycle activation in lung adenocarcinoma cells by the ErbB3/Phosphatidylinositol 3–kinase/Akt pathway
  1711. HIV-1-Tat protein activates Phosphatidylinositol 3–kinase/AKT-dependent survival pathways in Kaposi’s sarcoma cells
  1712. Activation of CR3‐mediated phagocytosis by MSP requires the RON receptor, tyrosine kinase activity, Phosphatidylinositol 3‐kinase, and protein kinase C ζ
  1713. Insulin activates CCAAT/enhancer binding proteins and proinflammatory gene expression through the Phosphatidylinositol 3–kinase pathway in vascular …
  1714. Insulin inhibits apoptosis of macrophage cell line, THP-1 cells, via Phosphatidylinositol–3–kinase–dependent pathway
  1715. 1α,25-Dihydroxyvitamin D3 Induces Vascular Smooth Muscle Cell Migration via Activation of Phosphatidylinositol 3–kinase
  1716. Phosphatidylinositol 3′-kinase-dependent activation of renal mesangial cell Ki-Ras and ERK by advanced glycation end products
  1717. … -like growth factor-1 receptor activation inhibits oxidized LDL-induced cytochrome C release and apoptosis via the Phosphatidylinositol 3 kinase/Akt signaling pathway
  1718. Phosphatidylinositol 3–kinase controls antineutrophil cytoplasmic antibodies—induced respiratory burst in human neutrophils
  1719. Follicle-stimulating hormone promotes nuclear exclusion of the forkhead transcription factor FoxO1a via Phosphatidylinositol 3–kinase in porcine granulosa cells
  1720. Role of Phosphatidylinositol 3‐kinase in neuronal survival and axonal outgrowth of adult mouse dorsal root ganglia explants
  1721. μ-opioid receptor activation prevents apoptosis following serum withdrawal in differentiated SH-SY5Y cells and cortical neurons via Phosphatidylinositol 3–kinase
  1722. Minimal mutation of the cytoplasmic tail inhibits the ability of E-cadherin to activate Rac but not Phosphatidylinositol 3–kinase: direct evidence of a role for …
  1723. Dexamethasone impairs insulin signalling and glucose transport by depletion of insulin receptor substrate-1, Phosphatidylinositol 3–kinase and protein kinase B in …
  1724. Regulation of the Phosphatidylinositol 3–kinase, Akt/protein kinase B, FRAP/mammalian target of rapamycin, and ribosomal S6 kinase 1 signaling pathways …
  1725. The role of Phosphatidylinositol 3′-kinase and its downstream signals in erbB-2-mediated transformation
  1726. Distinct role of Phosphatidylinositol 3–kinase and Rho family GTPases in Vav3-induced cell transformation, cell motility, and morphological changes
  1727. … -like peptide-1 inhibits apoptosis of insulin-secreting cells via a cyclic 5′-adenosine monophosphate-dependent protein kinase A-and a Phosphatidylinositol 3–kinase …
  1728. Phosphatidylinositol 3–kinase and Src family kinases are required for phosphorylation and membrane recruitment of Dok-1 in c-Kit signaling
  1729. Early stage-specific inhibitions of cardiomyocyte differentiation and expression of Csx/Nkx-2.5 and GATA-4 by Phosphatidylinositol 3–kinase inhibitor LY294002
  1730. Role of the insulin receptor substrate 1 and Phosphatidylinositol 3–kinase signaling pathway in insulin-induced expression of sterol regulatory element binding protein …
  1731. High-fat diet and leptin treatment alter skeletal muscle insulin-stimulated Phosphatidylinositol 3–kinase activity and glucose transport
  1732. … of interferon-γ-inducible GTPase inhibits coxsackievirus B3-induced apoptosis through the activation of the Phosphatidylinositol 3–kinase/Akt pathway and …
  1733. Transformation of mouse fibroblasts by Jaagsiekte sheep retrovirus envelope does not require Phosphatidylinositol 3–kinase
  1734. Y box-binding protein 1 induces resistance to oncogenic transformation by the Phosphatidylinositol 3–kinase pathway
  1735. … growth factor protects against 6-hydroxydopamine-induced oxidative stress by increasing expression of heme oxygenase-1 in a Phosphatidylinositol 3–kinase …
  1736. Phosphatidylinositol 3‐kinase is essential for kit ligand‐mediated survival, whereas interleukin‐3 and flt3 ligand induce expression of antiapoptotic Bcl‐2 family …
  1737. Insulin Resistance, Defective Insulin Receptor Substrate 2—Associated Phosphatidylinositol–3′ kinase Activation, and Impaired Atypical Protein kinase C (ζ/λ) …
  1738. Phosphatidylinositol 3–kinase may mediate isoproterenol-induced vascular relaxation in part through nitric oxide production
  1739. Inhibition of activator protein-1 binding activity and Phosphatidylinositol 3–kinase pathway by nobiletin, a polymethoxy flavonoid, results in augmentation of tissue …
  1740. B cell receptor-mediated Syk-independent activation of Phosphatidylinositol 3–kinase, Ras, and mitogen-activated protein kinase pathways
  1741. High-resolution structure of the pleckstrin homology domain of protein kinase b/akt bound to Phosphatidylinositol (3, 4, 5)-trisphosphate
  1742. Phosphatidylinositol 3–kinase activity is required for epidermal growth factor to suppress proteolysis
  1743. A new role for the p85-Phosphatidylinositol 3–kinase regulatory subunit linking FRAP to p70 S6 kinase activation
  1744. Phosphatidylinositol 3‐kinase and extracellular signal‐regulated kinase are recruited for Fc receptor‐mediated phagocytosis during monocyte‐to‐macrophage …
  1745. Phosphatidylinositol 3–kinase in cumulus cells is responsible for both suppression of spontaneous maturation and induction of gonadotropin-stimulated …
  1746. Inhibition of Phosphatidylinositol 3‐kinase and p70S6 kinase blocks osteogenic protein‐1 induction of alkaline phosphatase activity in fetal rat calvaria cells
  1747. Neuroprotection by scatter factor/hepatocyte growth factor and FGF‐1 in cerebellar granule neurons is Phosphatidylinositol 3‐kinase/akt‐dependent and MAPK/CREB …
  1748. Down-regulation of the Phosphatidylinositol 3–kinase/Akt pathway is involved in retinoic acid-induced phosphorylation, degradation, and transcriptional …
  1749. … -mediated endocytosis and recycling of the neuron-specific Na+/H+ exchanger NHE5 isoform: regulation by Phosphatidylinositol 3′-kinase and the actin …
  1750. Stretch-induced retinal vascular endothelial growth factor expression is mediated by Phosphatidylinositol 3–kinase and protein kinase C (PKC)-ζ but not by …
  1751. Antagonism of rat β-cell voltage-dependent K+ currents by exendin 4 requires dual activation of the cAMP/protein kinase A and Phosphatidylinositol 3–kinase …
  1752. Inhibition of Phosphatidylinositol 3‐kinase signaling negates the growth advantage imparted by a mutant epidermal growth factor receptor on human glioblastoma …
  1753. Up-regulation of Phosphatidylinositol 3–kinase and glucose transporter 4 in muscle of rats subjected to maternal undernutrition
  1754. AKT and the Phosphatidylinositol 3–kinase/AKT pathway: important molecular targets for lung cancer prevention and treatment
  1755. Insulin inhibits extracellular regulated kinase 1/2 phosphorylation in a Phosphatidylinositol 3‐kinase (PI3) kinase‐dependent manner in Neuro2a cells
  1756. Vascular endothelial growth factor causes pulmonary vasodilation through activation of the Phosphatidylinositol–3–kinase-nitric oxide pathway in the late …
  1757. Src-Dependent Association of Cas and p85 Phosphatidylinositol 3′-kinase in v-crk-Transformed Cells
  1758. Differential activation of Phosphatidylinositol 3–kinase signaling during proliferation and differentiation of lens epithelial cells
  1759. … -1-Phosphate and Lysophosphatidic Acid Prevent Apoptosis in Osteoblastic Cells via a Signaling Pathway Involving Gi Proteins and Phosphatidylinositol–3 kinase
  1760. Sphingosine-1-phosphate stimulates human glioma cell proliferation through Gi-coupled receptors: Role of ERK MAP kinase and Phosphatidylinositol 3–kinase β
  1761. Purinergic P2Y12 receptor blockade inhibits shear-induced platelet Phosphatidylinositol 3–kinase activation
  1762. Adrenomedullin reduces VEGF-induced endothelial adhesion molecules and adhesiveness through a Phosphatidylinositol 3′-kinase pathway
  1763. Fibronectin enhances viability and alters cytoskeletal functions (with effects on the Phosphatidylinositol 3‐kinase pathway) in small cell lung cancer
  1764. Phosphatidylinositol 3–kinase-dependent, MEK-independent proliferation in response to CaR activation
  1765. Studies of the mitogen-activated protein kinases and Phosphatidylinositol–3 kinase in the lens. 2. The intercommunications
  1766. Lipid rafts as the signaling scaffold for NK cell activation: tyrosine phosphorylation and association of LAT with Phosphatidylinositol 3‐kinase and phospholipase C‐γ …
  1767. Noncatalytic domain of uPA stimulates human extravillous trophoblast migration by using phospholipase C, Phosphatidylinositol 3–kinase and mitogen-activated …
  1768. Co-activation of the Phosphatidylinositol–3–kinase/Akt signaling pathway by N-methyl-D-aspartate and TrkB receptors in cerebellar granule cell neurons
  1769. 1α, 25-dihydroxyvitamin D3 stimulates activator protein 1 DNA-binding activity by a Phosphatidylinositol 3–kinase/Ras/MEK/extracellular signal regulated …
  1770. Selenite-induced survival of HuH7 hepatoma cells involves activation of focal adhesion kinase–Phosphatidylinositol 3–kinase-Akt pathway and Rac1
  1771. Glucose-induced Phosphatidylinositol 3–kinase and mitogen-activated protein kinase-dependent upregulation of the platelet-derived growth factor-β receptor …
  1772. Synthetic studies of the Phosphatidylinositol 3–kinase inhibitor LY294002 and related analogues
  1773. … from PC12 Cells by Increasing Ca2+-Responsible Secretory Vesicles through the Activation of Mitogen-Activated Protein kinase and Phosphatidylinositol 3–kinase
  1774. Phosphatidylinositol 3–kinase regulates bone morphogenetic protein-2 (BMP-2)-induced myocyte enhancer factor 2A-dependent transcription of BMP-2 gene …
  1775. … TCRγδ+ and Vδ2+ TCRγδ+ T lymphocytes from healthy donors and multiple sclerosis patients: Involvement of Phosphatidylinositol 3 kinase and calcium calmodulin …
  1776. Phosphatidylinositol 3–kinase and mek1/2 are necessary for insulin-like growth factor-I-induced vascular endothelial growth factor synthesis in prostate epithelial cells …
  1777. … up-regulated uncoupling protein-1 expression is mediated by insulin receptor substrate 1 through the Phosphatidylinositol 3–kinase/Akt signaling pathway in …
  1778. Pathogenic T cells in murine lupus exhibit spontaneous signaling activity through Phosphatidylinositol 3‐kinase and mitogen‐activated protein kinase pathways
  1779. Growth factor receptor-binding protein 10 (Grb10) as a partner of Phosphatidylinositol 3–kinase in metabolic insulin action
  1780. Phosphatidylinositol 3–kinase p85 adaptor function in T-cells: co-stimulation and regulation of cytokine transcription independent of associated p110
  1781. Peroxynitrite activates NF-E2-related factor 2/antioxidant response element through the pathway of Phosphatidylinositol 3–kinase: the role of nitric oxide synthase in rat …
  1782. BMP‐2 regulates cardiomyocyte contractility in a Phosphatidylinositol 3 kinase‐dependent manner
  1783. Phosphatidylinositol 3–kinase in angiotensin II-induced hypertrophy of vascular smooth muscle cells
  1784. Granulocyte-macrophage colony-stimulating factor signals for increased glucose transport via Phosphatidylinositol 3–kinase-and hydrogen peroxide …
  1785. Autocrine signaling through Ras regulates cell survival activity in human glioma cells: potential cross-talk between Ras and the Phosphatidylinositol 3–kinase-Akt …
  1786. Inhibition of the Phosphatidylinositol 3‘-kinase signaling pathway increases the responsiveness of pancreatic carcinoma cells to sulindac
  1787. … factor/scatter factor inhibits UVB-induced apoptosis of human keratinocytes but not of keratinocyte-derived cell lines via the Phosphatidylinositol 3–kinase/AKT …
  1788. Phosphatidylinositol 3‘-kinase and MAPK/ERK kinase 1/2 differentially regulate expression of vascular endothelial growth factor in human malignant astrocytoma cells
  1789. The Phosphatidylinositol 3–kinase inhibitor LY294002 binds the estrogen receptor and inhibits 17β-estradiol-induced transcriptional activity of an estrogen sensitive …
  1790. Inhibition of lymphocyte kinase Lck and Phosphatidylinositol 3–kinase by a novel immunosuppressant, lymphostin
  1791. Role of Phosphatidylinositol 3‐kinase in the binding of Bordetella pertussis to human monocytes
  1792. Human neutrophil-expressed CD28 interacts with macrophage B7 to induce Phosphatidylinositol 3–kinase-dependent IFN-γ secretion and restriction of Leishmania …
  1793. … of a signature of interferon-γ-induced polypeptides that includes manganese-superoxide dismutase and the p85β subunit of Phosphatidylinositol 3–kinase
  1794. Decay‐accelerating factor induction by tumour necrosis factor‐α, through a Phosphatidylinositol‐3 kinase and protein kinase C‐dependent pathway, protects murine …
  1795. Platelet factor 4 inhibits FGF2-induced endothelial cell proliferation via the extracellular signal–regulated kinase pathway but not by the Phosphatidylinositol 3–kinase …
  1796. Targeting of Mitogen-Activated Protein kinases and Phosphatidylinositol 3 kinase Inhibits Hepatocyte Growth Factor/Scatter Factor–Induced Angiogenesis
  1797. Preferential binding of Grb2 or Phosphatidylinositol 3–kinase to the met receptor has opposite effects on HGF-induced myoblast proliferation
  1798. Hypoxia protects human lung microvascular endothelial and epithelial-like cells against oxygen toxicity: role of Phosphatidylinositol 3–kinase
  1799. … in human basophils by p38 mitogen‐activated protein kinase: phosphorylation is sensitive to the effects of Phosphatidylinositol 3‐kinase inhibitors and calcium …
  1800. Inhibition of nuclear factor κB and Phosphatidylinositol 3‐kinase/Akt is essential for massive hepatocyte apoptosis induced by tumor necrosis factor α in mice
  1801. … induces intracellular accumulation of multivesicular bodies and major histocompatibility complex class II complexes: potential role of Phosphatidylinositol 3–kinase
  1802. Regulatory role of cAMP on expression of Cdk4 and p27Kip1 by inhibiting Phosphatidylinositol 3–kinase in corneal endothelial cells
  1803. … ) tyrosine kinase phosphorylates and activates phosphoinositide-dependent kinase 1 (PDK1): an alternative Phosphatidylinositol 3–kinase-independent pathway to …
  1804. … acid stimulates DNA synthesis in human microvascular endothelial cells via activation of Jak/STAT and Phosphatidylinositol 3–kinase/Akt signaling, leading to …
  1805. Necessity of tyrosine 719 and Phosphatidylinositol 3′-kinase–mediated signal pathway in constitutive activation and oncogenic potential of c-kit receptor tyrosine …
  1806. Recruitment of Phosphatidylinositol 3–kinase to CD28 inhibits HIV transcription by a Tat-dependent mechanism
  1807. Calcium receptor-induced serotonin secretion by parafollicular cells: role of Phosphatidylinositol 3–kinase-dependent signal transduction pathways
  1808. Motility enhancement by tumor-derived mutant E-cadherin is sensitive to treatment with epidermal growth factor receptor and Phosphatidylinositol 3–kinase inhibitors
  1809. Phosphatidylinositol 3–kinase regulates glycosylPhosphatidylinositol hydrolysis through PLC-γ2 activation in erythropoietin-stimulated cells
  1810. A new class of mutations reveals a novel function for the original Phosphatidylinositol 3–kinase binding site
  1811. Involvement of Phosphatidylinositol 3–kinase in nuclear translocation of protein kinase C ζ induced by C2-ceramide in rat hepatocytes
  1812. Enhancement of ischemia‐induced tyrosine phosphorylation of Kv1. 2 by vascular endothelial growth factor via activation of Phosphatidylinositol 3‐kinase
  1813. Involvement of the Src kinase Lyn in phospholipase C-γ2 phosphorylation and Phosphatidylinositol 3–kinase activation in Epo signalling
  1814. … granulocyte–macrophage colony‐stimulating factor and interleukin‐5, inhibits apoptosis of human basophils through Phosphatidylinositol 3‐kinase: requirement of NF …
  1815. Insulin promotes formation of polymerized microtubules by a Phosphatidylinositol 3–kinase-independent, actin-dependent pathway in 3T3-L1 adipocytes
  1816. … (EPO)-induced erythroid differentiation of K562 cells is accompanied by the nuclear translocation of Phosphatidylinositol 3–kinase and intranuclear generation of …
  1817. Leptin constrains phospholipase C-protein kinase C-induced insulin secretion via a Phosphatidylinositol 3–kinase-dependent pathway
  1818. β‐Adrenergic receptor‐mediated DNA synthesis in neonatal rat cardiac fibroblasts proceeds via a Phosphatidylinositol 3‐kinase dependent pathway refractory to the …
  1819. Regulation of phospholipase C-γ2 via Phosphatidylinositol 3–kinase in macrophages
  1820. Degradation of IκBα in activated RAW264. 7 cells is blocked by the Phosphatidylinositol 3–kinase inhibitor LY294002
  1821. LY294002, an inhibitor of Phosphatidylinositol–3–kinase, causes preferential induction of apoptosis in human multidrug resistant cells
  1822. Involvement of Phosphatidylinositol–3–kinase in membrane ruffling induced by P-glycoprotein substrates in multidrug-resistant carcinoma cells
  1823. Aspirin protects Caco-2 cells from apoptosis after serum deprivation through the activation of a Phosphatidylinositol 3–kinase/AKT/p21Cip/WAF1pathway
  1824. Lactate-induced translocation of GLUT1 and GLUT4 is not mediated by the Phosphatidylinositol–3–kinase pathway in the rat heart
  1825. Insulin‐like growth factor‐1 rescues the mutated FGF receptor 3 (G380R) expressing ATDC5 cells from apoptosis through Phosphatidylinositol 3‐kinase and MAPK
  1826. Insulin stimulates spreading of skeletal muscle cells involving the activation of focal adhesion kinase, Phosphatidylinositol 3‐kinase and extracellular signal regulated …
  1827. Binding of Phosphatidylinositol 3, 4, 5-trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational change
  1828. … -regulates the transcription of mouse lon homology ATP-dependent protease through extracellular signal-regulated protein kinase-and Phosphatidylinositol–3–kinase …
  1829. Phosphatidylinositol 3–kinase-like activity in Tetrahymena. Effects of wortmannin and LY 294002
  1830. Involvement of Phosphatidylinositol 3 kinase in the progesterone-induced oocyte maturation in Rana dybowskii
  1831. Growth arrest of PC12 cells by nerve growth factor is dependent on the Phosphatidylinositol 3‐kinase/Akt pathway via p75 neurotrophin receptor
  1832. … bad and glycogen synthase kinase–3 in a protein kinase A-dependent manner and prevents apoptosis following inhibition of Phosphatidylinositol 3–kinase
  1833. Wortmannin, a specific inhibitor of Phosphatidylinositol–3–kinase influences neurotrophin-induced spiral ganglion neurite growth
  1834. … -activated receptor gamma impedes Porphyromonas gingivalis lipopolysaccharide interference with salivary mucin synthesis through Phosphatidylinositol 3–kinase …
  1835. External Qi of Yan Xin life science technology can revive or suppress enzyme activity of Phosphatidylinositol 3–kinase
  1836. Matrix-independent activation of Phosphatidylinositol 3–kinase, Stat3, and cyclin A-associated Cdk2 Is essential for anchorage-independent growth of v-Ros …
  1837. Phosphatidylinositol 3–kinase is required for insulin-stimulated tyrosine phosphorylation of Shc in 3T3-L1 adipocytes
  1838. Transient ischemia enhances tyrosine phosphorylation and binding of the NMDA receptor to the Src homology 2 domain of Phosphatidylinositol 3‐kinase in the rat …
  1839. Kit/stem cell factor receptor‐induced Phosphatidylinositol 3′‐kinase signalling is not required for normal development and function of interstitial cells of Cajal in …
  1840. Cytoskeletal reorganization induced by insulin: involvement of Grb2/Ash, Ras and Phosphatidylinositol 3‐kinase signalling
  1841. Selective pharmacological inhibitors reveal the role of Syk tyrosine kinase, phospholipase C, Phosphatidylinositol–3′-kinase, and p38 mitogen-activated protein …
  1842. Phospholipase C and Phosphatidylinositol 3‐kinase signaling are involved in the exogenous arachidonic acid‐stimulated respiratory burst in human neutrophils
  1843. Control of proteolysis by norepinephrine and insulin in brown adipocytes: role of ATP, Phosphatidylinositol 3–kinase, and p70 S6K
  1844. … papillomavirus type 1 nucleotide 3225 3′ splice site can be rescued in a cell lacking splicing factor ASF/SF2 through activation of the Phosphatidylinositol 3–kinase …
  1845. Gene expression of the p85α regulatory subunit of Phosphatidylinositol 3–kinase in skeletal muscle from type 2 diabetic subjects
  1846. Detection of the p110 beta subunit of Phosphatidylinositol 3–kinase complexed with neutral endopeptidase.
  1847. Phosphatidylinositol 3–kinase mediates inhibitory effect of angiotensin II on sodium/glucose cotransporter in renal epithelial cells
  1848. Involvement of signaling through protein kinase C and Phosphatidylinositol 3–kinase in the excystation and metacystic development of Entamoeba invadens
  1849. … of glial cell‐derived neurotrophic factor and cardiotrophin‐1 protects PC12 cells from injury: Involvement of the Phosphatidylinositol 3‐kinase and mitogen‐activated …
  1850. α4 integrin signaling activates Phosphatidylinositol 3–kinase and stimulates T cell adhesion to intercellular adhesion molecule-1 to a similar extent as CD3, but …
  1851. Prolongation of insulin-induced activation of mitogen-activated protein kinases ERK 1/2 and Phosphatidylinositol 3–kinase by vanadyl sulfate, a protein tyrosine …
  1852. Cbl PYXXM motifs activate the P85 subunit of Phosphatidylinositol 3–kinase, Crk, atypical protein kinase C, and glucose transport during thiazolidinedione action in …
  1853. An E2F-binding site mediates the activation of the proliferative isoform of 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase by Phosphatidylinositol 3–kinase
  1854. Association between the Met326Ile Polymorphism of the p85α Regulatory Subunit of Phosphatidylinositol 3–kinase and Prostate Cancer Risk: A Prospective Study
  1855. … coli K-1 interaction with human brain micro-vascular endothelial cells triggers phospholipase C-γ1 activation downstream of Phosphatidylinositol 3–kinase
  1856. Exposure to asphalt fumes activates activator protein-1 through the Phosphatidylinositol 3–kinase/Akt signaling pathway in mouse epidermal cells
  1857. … Ethanol on the Rat Glutamate Excitatory Amino Acid Transporter Type 3 Expressed in Xenopus Oocytes: Role of Protein kinase C and Phosphatidylinositol 3‐kinase
  1858. Functional role of Phosphatidylinositol 3–kinase in direct tumor lysis by human natural killer cells
  1859. Involvement of type I protein kinase A in the differentiation of L6 myoblast in conjunction with Phosphatidylinositol 3–kinase.
  1860. … cell cycle progression through the synthesis of c-Myc protein by internal ribosome entry site–mediated translation via Phosphatidylinositol 3–kinase pathway in human …
  1861. Src tyrosine kinase-induced loss of luteinizing hormone responsiveness is via a Ras-dependent, Phosphatidylinositol–3–kinase independent pathway
  1862. A positive role of Phosphatidylinositol 3–kinase in aging phenotype expression in cultured human diploid fibroblasts
  1863. Interleukin-2 receptors and interleukin-2-mediated signaling in myelin: activation of diacylglycerol kinase and Phosphatidylinositol 3–kinase
  1864. Phosphatidylinositol 3–kinase Inhibitor Failed to Reduce Cerebral Vasospasm in Dog Model of Experimental Subarachnoid Hemorrhage
  1865. Roles of tyrosine kinase–, 1-Phosphatidylinositol 3–kinase–, and mitogen-activated protein kinase–signaling pathways in ethanol-induced contractions of rat aortic …
  1866. Activation and Phosphatidylinositol 3–kinase-dependent phosphorylation of protein kinase C-epsilon by the B cell antigen receptor
  1867. Two modes of secretion in pancreatic acinar cells: involvement of Phosphatidylinositol 3–kinase and regulation by capacitative Ca2+ entry
  1868. Lipidomic processes in homeostatic and LPS-modified cell renewal cycle. Role of Phosphatidylinositol 3–kinase pathway in biomembrane synthesis and restitution of …
  1869. … pylori Lipopolysaccharide Interference with Gastric Mucin Synthesis by Peroxisome Proliferator‐Activated Receptor γ Activation Involves Phosphatidylinositol 3‐kinase …
  1870. Defective Activation of Atypical Protein kinase C ζ and λ by Insulin and Phosphatidylinositol–3,4,5-(PO4)3 in Skeletal Muscle of Rats Following High-Fat Feeding and …
  1871. Rosiglitazone reverses insulin secretion altered by chronic exposure to free fatty acid via IRS-2-associated Phosphatidylinositol 3–kinase pathway.
  1872. α2 Adrenoceptor‐mediated vasoconstriction in porcine palmar lateral vein: role of Phosphatidylinositol 3‐kinase and EGF receptor transactivation
  1873. … factor-beta mediated contraction of human dermal fibroblast populated lattices is inhibited by Rho/GTPase inhibitor but does not require Phosphatidylinositol–3‘kinase.
  1874. ATP-sensitive K+ channel-mediated glucose uptake is independent of IRS-1/Phosphatidylinositol 3–kinase signaling
  1875. Phosphatidylinositol‐3 kinase p85 enhances expression from the myelin basic protein promoter in oligodendrocytes
  1876. Differential ligand recognition by the Src and Phosphatidylinositol 3–kinase Src homology 3 domains: circular dichroism and ultraviolet resonance Raman studies
  1877. The role of Phosphatidylinositol 3–kinase (PI3K) in CO2 stimulation of the Na+/HCO3-cotransporter (NBC)
  1878. Growth-inhibitory effect of Phosphatidylinositol 3–kinase inhibitor on human pancreatic cancer cells and expression of Bcl-2 family.
  1879. Growth and Molecular Profile of Lung Cancer Cells Expressing Ectopic LKB1 Down-Regulation of the Phosphatidylinositol 3′-Phosphate kinase/PTEN Pathway
  1880. ARNO but not cytohesin‐1 translocation is Phosphatidylinositol 3‐kinase‐dependent in HL‐60 cells
  1881. Stimulated tyrosine phosphorylation of Phosphatidylinositol 3–kinase causes acidic pH-induced contraction in spontaneously hypertensive rat aorta
  1882. Signal transducer and activator of transcription-3 and Phosphatidylinositol–3 kinase as coordinate regulators of melanoma cell response to glucocorticoid hormones
  1883. Phosphatidylinositol–3 kinase-dependent activation of Akt does not correlate with either high mitogenicity or cell migration induced by FGF-1.
  1884. The Phosphatidylinositol–3 kinase pathway is not essential for insulin-like growth factor I receptor-mediated clonogenic radioresistance
  1885. PDGF stimulates DNA synthesis in human vascular smooth muscle cells via a novel wortmannin-insensitive Phosphatidylinositol 3–kinase
  1886. Promoter polymorphisms− 359T/C and− 303A/G of the catalytic subunit p110β gene of human Phosphatidylinositol 3–kinase are not associated with insulin secretion …
  1887. Co-operation of Phosphatidylinositol transfer protein with phosphoinositide 3–kinase g in vitro
  1888. Activation of Phosphatidylinositol 3–kinase in human breast carcinoma
  1889. Cell adhesion induces the plasminogen activator inhibitor-1 gene expression through Phosphatidylinositol 3–kinase/Akt activation in anchorage dependent cells
  1890. Choline phosphate potentiates sphingosine-1-phosphate-induced Raf-1 kinase activation dependent of Ras–Phosphatidylinositol–3–kinase pathway
  1891. In the article “Phosphatidylinositol 3–kinase Is Required for the Expression But Not for the Induction or the Maintenance of Long-Term Potentiation in the Hippocampal …
  1892. … cultured with a fusion protein of insulin‐like growth factor II (IGF‐II) and interleukin 3 (IL‐3) is associated with increases in Bcl‐xL and Phosphatidylinositol‐3 kinase …
  1893. Search for a molecular determinant in Phosphatidylinositol–3–kinase molecules, involved in the interaction with the beta-gamma-G protein dimer
  1894. Expression of an active p110 catalytic subunit of Phosphatidylinositol 3‐kinase alters the proliferative capacity of interleukin‐2 receptor signals
  1895. CD40 induces human multiple myeloma cell migration via Phosphatidylinositol 3–kinase/AKT/NF-B signaling
  1896. Novel non-transcriptional mechanisms for estrogen receptor signaling in the cardiovascular system: Interaction of estrogen receptor α with Phosphatidylinositol 3-OH …
  1897. Role of the Phosphatidylinositol 3 kinase-Akt
  1898. TNF-alpha induced chondrocyte apoptosis in NF-κB suppression is augmented by inhibition of p38 mitogen-activated protein kinase or Phosphatidylinositol 3–kinase
  1899. Defective Hyphal Induction of a Candida albicans Phosphatidylinositol 3-Phosphate 5-kinase Null Mutant on Solid Media Does Not Lead to Decreased Virulence
  1900. The biological effect of the Phosphatidylinositol 3–kinase wortmannin following thermal neutron irradiation
  1901. Acetylcholine-induced production of reactive oxygen species in adult rabbit ventricular myocytes is dependent on Phosphatidylinositol 3-and Src-kinase activation and …
  1902. A Role for the Phosphatidylinositol–3–kinase Pathway in Preconditioning
  1903. Roles of Phosphatidylinositol 3–kinase (PI3K) and Rac1
  1904. Roles of Phosphatidylinositol 3–kinase (PI3K) and Rac 1
  1905. Gene expression profile analysis of the Phosphatidylinositol 3–kinase pathway in the developing small intestine
  1906. Defining the physiological role of Phosphatidylinositol 3–kinase protein kinase activity
  1907. Characterisation of aggresome formation by the class III Phosphatidylinositol 3–kinase and its adaptor protein, p150.
  1908. Class IA Phosphatidylinositol 3–kinase involvement in cytoskeletal regulation
  1909. Novel age-associated induction of components of the Phosphatidylinositol–3 kinase (PI3K)/Akt signaling in the intestine
  1910. TEL/platelet-derived growth factor receptor β activates Phosphatidylinositol 3 (PI3) kinase and requires PI3 kinase to regulate the cell cycle
  1911. Negative regulation of transforming growth factorbeta/SMAD by Phosphatidylinositol 3–kinase pathway in neuroblastomas
  1912. Investigating the effect of altered nutrition on signalling via Drosophila class 1A Phosphatidylinositol–3 kinase (PI3K), and functional analysis of PI3K mutated …
  1913. Connective tissue growth factor inhibits apoptosis of human hypertrophic scar fibroblasts through Phosphatidylinositol 3–kinase/protein kinase B signal pathway
  1914. Regulation of androgen receptor activity and degradation by the Phosphatidylinositol–3–kinase/Akt pathway, PTEN tumor suppressor, and Mdm2
  1915. Epidermal growth factor-induced DNA synthesis: key roles for Phosphatidylinositol 3–kinase and the adaptor protein Gab2
  1916. Requirement of BMP-2-induced Phosphatidylinositol 3–kinase and Akt serine/threonine kinase in osteoblast differentiation and Smad-dependent BMP-2 gene …
  1917. In vivo administration of glucosamine inhibited Phosphatidylinositol 3–kinase activity without affecting tyrosine phosphorylation of the insulin receptor or insulin …
  1918. Functional Cooperation among Ras, STAT5, and Phosphatidylinositol 3–kinase Is Required for Full Oncogenic Activities of BCR/ABL in K562 Cells
  1919. Apoptosis of differentiated HL-60 cells induced by inhibitor of Phosphatidylinositol 3–kinase
  1920. 1141. Insulin-Like Growth Factor-1 Enhances Plasmid Transgene Expression through a Phosphatidylinositol 3–kinase-Dependent Pathway
  1921. Phosphatidylinositol (3, 4, 5) P3 is essential but not sufficient for protein kinase B (PKB) activation; Phosphatidylinositol (3, 4) P2 is required for PKB …
  1922. DEFECTS IN INTERMEDIATE INSULIN SIGNALING IN SKELETAL MUSCLE: Phosphatidylinositol (PI) 3–kinase AND GLUCOSE TRANSPORT
  1923. … CANCER: ANTIMONY VERSUS TECHNETIUM-99 FILTERED SULFUR COLLOID52. THE INVOLVEMENT OF Phosphatidylinositol 3–kinase (PI3-K)/AKT …
  1924. Insulin activates CCAAT/enhancer binding proteins and proinflammatory gene expression through the Phosphatidylinositol 3–kinase pathway in vascular smooth …
  1925. Phosphatidylinositol kinase enzymes regulate the retrograde axonal transport of NT‐3 and NT‐4 in sympathetic and sensory neurons
  1926. The Role of Phosphatidylinositol 3‘-OH kinase Signaling in Mammary Tumorigenesis
  1927. Epithelial–mesenchymal transition in development and cancer: role of Phosphatidylinositol 3′ kinase/AKT pathways
  1928. The pivotal role of Phosphatidylinositol 3–kinase–Akt signal transduction in virus survival
  1929. Phosphatidylinositol 3–kinase mutations identified in human cancer are oncogenic
  1930. Targeting the Phosphatidylinositol–3 kinase/Akt pathway for the treatment of cancer.
  1931. Inhibition of Rho-kinase leads to rapid activation of Phosphatidylinositol 3–kinase/protein kinase Akt and cardiovascular protection
  1932. The prognostic significance of Phosphatidylinositol 3–kinase pathway activation in human gliomas
  1933. Exercise activates the Phosphatidylinositol 3–kinase pathway
  1934. Early involvement of the Phosphatidylinositol 3–kinase/Akt pathway in lung cancer progression
  1935. Postconditioning: a form of “modified reperfusion” protects the myocardium by activating the Phosphatidylinositol 3–kinase-Akt pathway
  1936. Cell type-specific expression of the IκB kinases determines the significance of Phosphatidylinositol 3–kinase/Akt signaling to NF-κB activation
  1937. Type I transforming growth factor β receptor binds to and activates Phosphatidylinositol 3–kinase
  1938. Phosphatidylinositol 3–kinase–Akt pathway plays a critical role in early cardiomyogenesis by regulating canonical Wnt signaling
  1939. Regulation of Cu/Zn-superoxide dismutase expression via the Phosphatidylinositol 3 kinase/Akt pathway and nuclear factor-κB
  1940. The Phosphatidylinositol‐3 kinase pathway regulates bladder cancer cell invasion
  1941. Novel role for Na, K-ATPase in Phosphatidylinositol 3–kinase signaling and suppression of cell motility
  1942. Inhibition of Phosphatidylinositol 3–kinase dephosphorylates BAD and promotes apoptosis in myeloid leukemias.
  1943. … growth factor transcriptional activation is mediated by hypoxia-inducible factor 1α, HDM2, and p70S6K1 in response to Phosphatidylinositol 3–kinase/AKT …
  1944. … metabolites stimulate endothelial cell growth and angiogenesis via mitogen-activated protein kinase and Phosphatidylinositol 3–kinase/Akt signaling pathways
  1945. Focal adhesion kinase is upstream of Phosphatidylinositol 3–kinase/Akt in regulating fibroblast survival in response to contraction of type I collagen matrices …
  1946. Pancreatic stellate cell migration: role of the Phosphatidylinositol 3–kinase (PI3–kinase) pathway
  1947. Inhibition of the Phosphatidylinositol 3–kinase/Akt pathway by inositol pentakisphosphate results in antiangiogenic and antitumor effects
  1948. Tobacco Carcinogen-Induced Cellular Transformation Increases Activation of the Phosphatidylinositol 3′-kinase/Akt Pathway in Vitro and in Vivo
  1949. Phosphatidylinositol–3–kinase signaling is required for erythropoietin-mediated acute protection against myocardial ischemia/reperfusion injury
  1950. Activation of the Phosphatidylinositol 3–kinase/Akt pathway contributes to survival of primary epithelial cells infected with the periodontal pathogen Porphyromonas …
  1951. Cutting edge: T cell development requires the combined activities of the p110γ and p110δ catalytic isoforms of Phosphatidylinositol 3–kinase
  1952. Auxin-induced reactive oxygen species production requires the activation of Phosphatidylinositol 3–kinase
  1953. Involvement of the Phosphatidylinositol 3–kinase/rac1 and cdc42 pathways in radial migration of cortical neurons
  1954. Nongenomic androgen activation of Phosphatidylinositol 3‐kinase/Akt signaling pathway in MC3T3‐E1 osteoblasts
  1955. Flavivirus activates Phosphatidylinositol 3–kinase signaling to block caspase-dependent apoptotic cell death at the early stage of virus infection
  1956. Activation of the pro-survival Phosphatidylinositol 3–kinase/AKT pathway by transforming growth factor-β1 in mesenchymal cells is mediated by p38 MAPK …
  1957. Phosphatidylinositol 3–kinase activates ERK in primary sensory neurons and mediates inflammatory heat hyperalgesia through TRPV1 sensitization
  1958. Interleukin-18 is a pro-hypertrophic cytokine that acts through a Phosphatidylinositol 3–kinase-phosphoinositide-dependent kinase-1-Akt-GATA4 signaling …
  1959. The p85α subunit of Phosphatidylinositol 3′-kinase binds to and stimulates the GTPase activity of Rab proteins
  1960. Knockdown of MTP18, a novel Phosphatidylinositol 3–kinase-dependent protein, affects mitochondrial morphology and induces apoptosis
  1961. Cross-Talk between Phosphatidylinositol 3–kinase/AKT and c-Jun NH2-Terminal kinase Mediates Survival of Isolated Human Islets
  1962. Endoplasmic reticulum stress–induced apoptosis is partly mediated by reduced insulin signaling through Phosphatidylinositol 3–kinase/Akt and increased glycogen …
  1963. Bisphenol a accelerates terminal differentiation of 3T3-L1 cells into adipocytes through the Phosphatidylinositol 3–kinase pathway
  1964. Lithium activates the Wnt and Phosphatidylinositol 3–kinase Akt signaling pathways to promote cell survival in the absence of soluble survival factors
  1965. Synergistic augmentation of rapamycin-induced autophagy in malignant glioma cells by Phosphatidylinositol 3–kinase/protein kinase B inhibitors
  1966. Adrenomedullin infusion attenuates myocardial ischemia/reperfusion injury through the Phosphatidylinositol 3–kinase/Akt-dependent pathway
  1967. Activation of Phosphatidylinositol 3–kinase by cellular prion protein and its role in cell survival
  1968. BDNF regulates the translation of a select group of mRNAs by a mammalian target of rapamycin-Phosphatidylinositol 3–kinase-dependent pathway during neuronal …
  1969. Inhibition of Phosphatidylinositol 3′-kinase/AKT signaling promotes apoptosis of primary effusion lymphoma cells
  1970. The Phosphatidylinositol 3–kinase/Akt pathway enhances Smad3-stimulated mesangial cell collagen I expression in response to transforming growth factor-β1
  1971. Phosphatidylinositol 3′-kinase activation leads to multidrug resistance protein-1 expression and subsequent chemoresistance in advanced prostate cancer cells
  1972. Latent membrane protein 2A inhibits transforming growth factor-β1-induced apoptosis through the Phosphatidylinositol 3–kinase/Akt pathway
  1973. Microglia release activators of neuronal proliferation mediated by activation of mitogen‐activated protein kinase, Phosphatidylinositol‐3‐kinase/Akt and delta–Notch …
  1974. Acanthamoeba castellanii Induces Host Cell Death via a Phosphatidylinositol 3–kinase-Dependent Mechanism
  1975. Regulation of muscle protein degradation: coordinated control of apoptotic and ubiquitin-proteasome systems by Phosphatidylinositol 3 kinase
  1976. Both mitogen-activated protein kinase and Phosphatidylinositol 3–kinase signalling are required in epidermal growth factor-induced human trophoblast migration
  1977. … protein regulation of early osteoblast genes in human marrow stromal cells is mediated by extracellular signal-regulated kinase and Phosphatidylinositol 3–kinase …
  1978. Ceramide-1-phosphate promotes cell survival through activation of the Phosphatidylinositol 3–kinase/protein kinase B pathway
  1979. … inhibits vascular endothelial growth factor-induced angiogenesis; inhibition of endothelial cell survival and proliferation by targeting Phosphatidylinositol 3′-kinase …
  1980. Gi-protein-dependent inhibition of IL-12 production is mediated by activation of the Phosphatidylinositol 3–kinase-protein 3 kinase B/Akt pathway and JNK
  1981. … through proteasomal degradation of HER2/neu in HER2/neu-overexpressing breast cancer cells via the Phosphatidylinositol 3–kinase/Akt-dependent pathway
  1982. Emodin inhibits tumor cell migration through suppression of the Phosphatidylinositol 3–kinase-Cdc42/Rac1 pathway
  1983. Inhibition of Phosphatidylinositol 3–kinase sensitizes ovarian cancer cells to carboplatin and allows adjunct chemotherapy treatment
  1984. … Induces Rapid Activation of Akt/Protein kinase B-Mammalian Target of Rapamycin-p70S6K Cascade through Phosphatidylinositol 3–kinase in Human Fibroblasts
  1985. REDD1 integrates hypoxia-mediated survival signaling downstream of Phosphatidylinositol 3–kinase
  1986. Mechanisms of erythropoietin‐mediated cardioprotection during ischemia‐reperfusion injury: role of protein kinase C and Phosphatidylinositol 3‐kinase signaling
  1987. Sequential Activation of Phosphatidylinositol 3–kinase, βPix, Rac1, and Nox1 in Growth Factor-Induced Production of H2O2
  1988. Production of matrix metalloproteinase‐9 by activated human monocytes involves a Phosphatidylinositol‐3 kinase/Akt/IKKα/NF‐κB pathway
  1989. Isoflurane protects against myocardial infarction during early reperfusion by activation of Phosphatidylinositol–3–kinase signal transduction: evidence for anesthetic …
  1990. … progenitors and differentiated osteoblasts by β-catenin-dependent and-independent signaling cascades involving Src/ERK and Phosphatidylinositol 3–kinase …
  1991. Differential membrane localization of ERas and Rheb, two Ras-related proteins involved in the Phosphatidylinositol 3–kinase/mTOR pathway
  1992. Human placental growth hormone increases expression of the p85 regulatory unit of Phosphatidylinositol 3–kinase and triggers severe insulin resistance in skeletal …
  1993. Induction of androgen receptor expression by Phosphatidylinositol 3–kinase/Akt downstream substrate, FOXO3a, and their roles in apoptosis of LNCaP …
  1994. Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and Phosphatidylinositol 3–kinase/Akt signaling
  1995. WAVE3-mediated cell migration and lamellipodia formation are regulated downstream of Phosphatidylinositol 3–kinase
  1996. Role of Phosphatidylinositol 3–kinase in the development of hepatocyte preconditioning
  1997. Overexpression of NBS1 contributes to transformation through the activation of Phosphatidylinositol 3–kinase/Akt
  1998. TGF-β1 represses activation and resultant death of microglia via inhibition of Phosphatidylinositol 3–kinase activity
  1999. Inhibition of Phosphatidylinositol 3–kinase amplifies TEGDMA-induced apoptosis in primary human pulp cells
  2000. Mutant epidermal growth factor receptor displays increased signaling through the Phosphatidylinositol–3 kinase/AKT pathway and promotes radioresistance in cells of …
  2001. Atypical protein kinase C (PKCζ/λ) is a convergent downstream target of the insulin-stimulated Phosphatidylinositol 3–kinase and TC10 signaling pathways
  2002. Lipopolysaccharide-induced c-Jun NH2-terminal kinase activation in human neutrophils: role of Phosphatidylinositol 3–kinase and Syk-mediated pathways
  2003. Modulation of Phosphatidylinositol‐3‐kinase/protein kinase B‐and mitogen‐activated protein kinase‐pathways by tea polyphenols in human prostate cancer cells
  2004. Inhibition of Phosphatidylinositol–3–kinase causes increased sensitivity to radiation through a PKB-dependent mechanism
  2005. Statins prevent oxidized LDL-induced injury of glomerular podocytes by activating the Phosphatidylinositol 3–kinase/AKT-signaling pathway
  2006. Akt2, a novel functional link between p38 mitogen-activated protein kinase and Phosphatidylinositol 3–kinase pathways in myogenesis
  2007. Leptin increases cardiomyocyte hyperplasia via extracellular signal-regulated kinase-and Phosphatidylinositol 3–kinase-dependent signaling pathways
  2008. Regulation of heme oxygenase-1 expression through the Phosphatidylinositol 3–kinase/Akt pathway and the Nrf2 transcription factor in response to the …
  2009. Mammalian target of rapamycin positively regulates collagen type I production via a Phosphatidylinositol 3–kinase-independent pathway
  2010. Alteration of Phosphatidylinositol 3–kinase cascade in the multilobulated nuclear formation of adult T cell leukemia/lymphoma (ATLL)
  2011. Aging is associated with decreased pancreatic acinar cell regeneration and Phosphatidylinositol 3–kinase/Akt activation
  2012. Insulin-like growth factor-1 (IGF-1) inversely regulates atrophy-induced genes via the Phosphatidylinositol 3–kinase/Akt/mammalian target of rapamycin (PI3K …
  2013. PIKE (Phosphatidylinositol 3–kinase enhancer)-A GTPase stimulates Akt activity and mediates cellular invasion
  2014. Se-methylselenocysteine inhibits Phosphatidylinositol 3–kinase activity of mouse mammary epithelial tumor cells in vitro
  2015. CXCL16 signals via Gi, Phosphatidylinositol 3–kinase, Akt, IκB kinase, and nuclear factor-κB and induces cell-cell adhesion and aortic smooth muscle cell …
  2016. Dexamethasone induces apoptosis in proliferative chondrocytes through activation of caspases and suppression of the Akt-Phosphatidylinositol 3′-kinase signaling …
  2017. WNK1 activates SGK1 by a Phosphatidylinositol 3–kinase-dependent and non-catalytic mechanism
  2018. Phosphatidylinositol 3–kinase-Mediated Effects of Glucose on Vacuolar H+-ATPase Assembly, Translocation, and Acidification of Intracellular Compartments in Renal …
  2019. The Phosphatidylinositol–3–kinase inhibitor PX-866 overcomes resistance to the epidermal growth factor receptor inhibitor gefitinib in A-549 human non–small cell …
  2020. … protein Gab1 is an essential component of an indirect mechanism for fibroblast growth factor stimulation of the Phosphatidylinositol 3–kinase/Akt antiapoptotic pathway
  2021. Transforming growth factor-β activation of Phosphatidylinositol 3–kinase is independent of Smad2 and Smad3 and regulates fibroblast responses via p21-activated …
  2022. Isoflurane-induced myocardial preconditioning is dependent on Phosphatidylinositol–3–kinase/Akt signalling
  2023. PTEN, but not SHIP2, suppresses insulin signaling through the Phosphatidylinositol 3–kinase/Akt pathway in 3T3-L1 adipocytes
  2024. Retroinfusion of embryonic endothelial progenitor cells attenuates ischemia-reperfusion injury in pigs: role of Phosphatidylinositol 3–kinase/AKT kinase
  2025. … stress induces insulin resistance by activating the nuclear factor-κB pathway and disrupting normal subcellular distribution of Phosphatidylinositol 3–kinase
  2026. Phosphatidylinositol 3–kinase C2α is essential for ATP-dependent priming of neurosecretory granule exocytosis
  2027. … -macrophage colony-stimulating factor signaling and microglial proliferation by anti-CD45RO: role of Hck tyrosine kinase and Phosphatidylinositol 3–kinase/Akt
  2028. Phosphatidylinositol 3–kinase and mTOR signaling pathways regulate RNA polymerase I transcription in response to IGF-1 and nutrients
  2029. Presenilins mediate Phosphatidylinositol 3–kinase/AKT and ERK activation via select signaling receptors: selectivity of PS2 in platelet-derived growth factor …
  2030. Cross-talk between CD14 and complement receptor 3 promotes phagocytosis of mycobacteria: regulation by Phosphatidylinositol 3–kinase and cytohesin-1
  2031. Carbon monoxide differentially modulates STAT1 and STAT3 and inhibits apoptosis via a Phosphatidylinositol 3–kinase/Akt and p38 kinase-dependent STAT3 …
  2032. Phosphatidylinositol 3‐kinase and Akt effectors mediate insulin‐like growth factor‐I neuroprotection in dorsal root ganglia neurons
  2033. Transformation potential of Ras isoforms correlates with activation of Phosphatidylinositol 3–kinase but not ERK
  2034. Hypoxia-induced activation of p38 mitogen-activated protein kinase and Phosphatidylinositol 3′-kinase signaling pathways contributes to expression of interleukin 8 …
  2035. Participation of prolactin receptors and Phosphatidylinositol 3–kinase and MAP kinase pathways in the increase in pancreatic islet mass and sensitivity to …
  2036. … ligand (TRAIL) induces rheumatoid arthritis synovial fibroblast proliferation through mitogen-activated protein kinases and Phosphatidylinositol 3–kinase/Akt
  2037. A3 adenosine receptor activation inhibits cell proliferation via Phosphatidylinositol 3–kinase/Akt-dependent inhibition of the extracellular signal-regulated …
  2038. … -I regulates proliferation and osteoblastic differentiation of calcifying vascular cells via extracellular signal-regulated protein kinase and Phosphatidylinositol 3–kinase …
  2039. … affecting the cell cycle, growth, maintenance, and drug sensitivity are preferentially regulated by anti-HER2 antibody through Phosphatidylinositol 3–kinase …
  2040. Increased phosphorylation of AKAP by inhibition of Phosphatidylinositol 3–kinase enhances human sperm motility through tail recruitment of protein kinase A
  2041. Vacuolar H+-ATPase binding to microfilaments: regulation in response to Phosphatidylinositol 3–kinase activity and detailed characterization of the actin …
  2042. Inhibition of Phosphatidylinositol 3–kinase modifies boar sperm motion parameters
  2043. Semaphorin 4D/plexin-B1 induces endothelial cell migration through the activation of PYK2, Src, and the Phosphatidylinositol 3–kinase-Akt pathway
  2044. Phosphatidylinositol 3–kinase inhibition down-regulates survivin and facilitates TRAIL-mediated apoptosis in neuroblastomas
  2045. Phosphatidylinositol 3–kinase/Akt regulates angiotensin II–induced inhibition of apoptosis in microvascular endothelial cells by governing survivin expression and …
  2046. Insulin-mediated down-regulation of apolipoprotein A5 gene expression through the Phosphatidylinositol 3–kinase pathway: role of upstream stimulatory factor
  2047. Dual regulation of MMP-2 expression by the type 1 insulin-like growth factor receptor: the Phosphatidylinositol 3–kinase/Akt and Raf/ERK pathways transmit …
  2048. … induced expression of CXC chemokine receptor 4 on non-small cell lung cancer cells is regulated by the Phosphatidylinositol 3–kinase/PTEN/AKT/mammalian …
  2049. Phosphatidylinositol 3–kinase is required for rhinovirus-induced airway epithelial cell interleukin-8 expression
  2050. Zn2+ inhibits mitochondrial movement in neurons by Phosphatidylinositol 3–kinase activation
  2051. … activate the AKT kinase in multiple myeloma cells by up-regulating the insulin-like growth factor receptor/insulin receptor substrate-1/Phosphatidylinositol 3–kinase …
  2052. Activation of Phosphatidylinositol 3–kinase and extracellular signal-regulated kinase is required for glial cell line-derived neurotrophic factor-induced migration and …
  2053. Platelet-derived growth factor stimulates membrane lipid synthesis through activation of Phosphatidylinositol 3–kinase and sterol regulatory element-binding …
  2054. Phosphatidylinositol 3–kinase is involved in α2 (I) collagen gene expression in normal and scleroderma fibroblasts
  2055. IGF-I inhibits apoptosis through the activation of the Phosphatidylinositol 3–kinase/Akt pathway in pituitary cells
  2056. Phosphatidylinositol 3–kinase Offsets cAMP-Mediated Positive Inotropic Effect via Inhibiting Ca2+ Influx in Cardiomyocytes
  2057. Formation of E-cadherin-mediated cell-cell adhesion activates AKT and mitogen activated protein kinase via Phosphatidylinositol 3 kinase and ligand-independent …
  2058. Lipoteichoic acid induces nuclear factor‐κB activation and nitric oxide synthase expression via Phosphatidylinositol 3‐kinase, Akt, and p38 MAPK in RAW 264.7 …
  2059. Glucocorticoid receptor counteracts tumorigenic activity of Akt in skin through interference with the Phosphatidylinositol 3–kinase signaling pathway
  2060. Phosphatidylinositol–3 kinase/Akt and GSK-3 mediated cytoprotective effect of epigallocatechin gallate on oxidative stress-injured neuronal-differentiated N18D3 cells
  2061. Identification of nonsteroidal anti-inflammatory drug-activated gene (NAG-1) as a novel downstream target of Phosphatidylinositol 3–kinase/AKT/GSK-3β …
  2062. … -dependent insulinotropic polypeptide (GIP) stimulation of pancreatic β-cell survival is dependent upon Phosphatidylinositol 3–kinase (PI3K)/protein kinase B …
  2063. Role of the Phosphatidylinositol 3′-kinase–Akt signal pathway in the proliferation of human pancreatic ductal carcinoma cell lines
  2064. Signal regulatory protein α ligation induces macrophage nitric oxide production through JAK/STAT-and Phosphatidylinositol 3–kinase/Rac1/NAPDH oxidase/H2O2 …
  2065. Stable activation of Phosphatidylinositol 3–kinase in the T cell immunological synapse stimulates Akt signaling to FoxO1 nuclear exclusion and cell growth control
  2066. Activation of the Phosphatidylinositol 3–kinase/Akt pathway prevents radiation-induced apoptosis in breast cancer cells
  2067. Hyaluronic acid induces osteopontin via the Phosphatidylinositol 3–kinase/Akt pathway to enhance the motility of human glioma cells
  2068. … regulated by coexpression of human epidermal growth factor receptor 2 and epidermal growth factor receptor via Phosphatidylinositol 3–kinase/AKT signaling pathway …
  2069. CD28 regulates the translation of Bcl-xL via the Phosphatidylinositol 3–kinase/mammalian target of rapamycin pathway
  2070. Impaired activation of Phosphatidylinositol 3–kinase by leptin is a novel mechanism of hepatic leptin resistance in diet-induced obesity
  2071. Regulation of cholinergic gene expression by nerve growth factor depends on the Phosphatidylinositol‐3′‐kinase pathway
  2072. Inhibition of Phosphatidylinositol 3′-kinase induces preferentially killing of PTEN-null T leukemias through AKT pathway
  2073. Nickel Compounds Act through Phosphatidylinositol–3–kinase/Akt-Dependent, p70S6k-Independent Pathway to Induce Hypoxia Inducible Factor Transactivation and …
  2074. Enteric neuroblasts require the Phosphatidylinositol 3–kinase/Akt/Forkhead pathway for GDNF-stimulated survival
  2075. Differential activation of the Phosphatidylinositol 3′-kinase/Akt survival pathway by ionizing radiation in tumor and primary endothelial cells
  2076. Activation of Rac1 by Phosphatidylinositol 3‐kinase in vivo: role in activation of mitogen‐activated protein kinase (MAPK) pathways and retinoic acid‐induced …
  2077. Induction of KLF2 by fluid shear stress requires a novel promoter element activated by a Phosphatidylinositol 3–kinase-dependent chromatin-remodeling …
  2078. Insulin generates free radicals by an NAD (P) H, Phosphatidylinositol 3′-kinase-dependent mechanism in human skin fibroblasts ex vivo
  2079. Insulin-like growth factor-1 regulates endogenous RUNX2 activity in endothelial cells through a Phosphatidylinositol 3–kinase/ERK-dependent and Akt …
  2080. Phosphatidylinositol 3–kinase and frabin mediate Cryptosporidium parvum cellular invasion via activation of Cdc42
  2081. … /human herpesvirus 8 envelope glycoprotein gB induces the integrin-dependent focal adhesion kinase-Src-Phosphatidylinositol 3–kinase-rho GTPase signal pathways …
  2082. Nerve growth factor promotes the survival of sympathetic neurons through the cooperative function of the protein kinase C and Phosphatidylinositol 3–kinase …
  2083. Roles of the Ras-MEK-mitogen-activated protein kinase and Phosphatidylinositol 3–kinase-Akt-mTOR pathways in Jaagsiekte sheep retrovirus-induced transformation …
  2084. Inhibition of p38 mitogen-activated protein kinase and Phosphatidylinositol 3–kinase decreases UVB-induced activator protein-1 and cyclooxygenase-2 in a SKH-1 …
  2085. … induces proliferation, migration, and TGF-β1 expression in mouse glomerular endothelial cells via mitogen-activated protein kinase and Phosphatidylinositol 3–kinase
  2086. p38 and EGF receptor kinase-mediated activation of the Phosphatidylinositol 3–kinase/Akt pathway is required for Zn2+-induced cyclooxygenase-2 expression
  2087. Follicle-stimulating hormone activation of hypoxia-inducible factor-1 by the Phosphatidylinositol 3–kinase/AKT/Ras homolog enriched in brain (Rheb) …
  2088. … line-derived neurotrophic factor increases intracellular calcium concentration: role of calcium/calmodulin in the activation of the Phosphatidylinositol 3–kinase …
  2089. Reciprocal control of Forkhead box O 3a and c-Myc via the Phosphatidylinositol 3–kinase pathway coordinately regulates p27Kip1 levels
  2090. Facilitation of conditioned fear extinction by d-cycloserine is mediated by mitogen-activated protein kinase and Phosphatidylinositol 3–kinase cascades and requires …
  2091. … box transcription factor FOXO3a regulates estrogen receptor alpha expression and is repressed by the Her-2/neu/Phosphatidylinositol 3–kinase/Akt signaling pathway
  2092. Medroxyprogesterone acetate induces cell proliferation through up-regulation of cyclin D1 expression via Phosphatidylinositol 3–kinase/Akt/nuclear factor-κB cascade …
  2093. … is enhanced by N-methyl-D-aspartate receptor activation: essential role of a TNF receptor 2-mediated Phosphatidylinositol 3–kinase-dependent NF-κB …
  2094. LY294002 inhibits LPS-induced NO production through a inhibition of NF-κB activation: independent mechanism of Phosphatidylinositol 3–kinase
  2095. Resistin promotes smooth muscle cell proliferation through activation of extracellular signal–regulated kinase 1/2 and Phosphatidylinositol 3–kinase pathways
  2096. A late, prolonged activation of the Phosphatidylinositol 3–kinase pathway is required for T cell proliferation
  2097. Morphine enhances isoflurane-induced postconditioning against myocardial infarction: the role of Phosphatidylinositol–3–kinase and opioid receptors in rabbits
  2098. Calcium-induced Human Keratinocyte Differentiation Requires src- and fyn-mediated Phosphatidylinositol 3–kinase–dependent Activation of Phospholipase C-γ1
  2099. FGF-2 induced by interleukin-1β through the action of Phosphatidylinositol 3–kinase mediates endothelial mesenchymal transformation in corneal endothelial …
  2100. … of peroxisome proliferator-activated receptor-γ by insulin and C-peptide in kidney proximal tubular cells: dependent on Phosphatidylinositol 3–kinase activity
  2101. IL-18 induces monocyte chemotactic protein-1 production in macrophages through the Phosphatidylinositol 3–kinase/Akt and MEK/ERK1/2 pathways
  2102. Erythropoietin just before reperfusion reduces both lethal arrhythmias and infarct size via the Phosphatidylinositol–3 kinase-dependent pathway in canine hearts
  2103. FSH activates Phosphatidylinositol 3–kinase/protein kinase B signaling pathway in 20-day-old Sertoli cells independently of IGF-I
  2104. Dexamethasone suppresses antigen-induced activation of Phosphatidylinositol 3–kinase and downstream responses in mast cells
  2105. Inhibition of the Phosphatidylinositol 3–kinase/Akt/mammalian target of rapamycin pathway but not the MEK/ERK pathway attenuates laminin-mediated small cell lung …
  2106. Apoptosis and inhibition of the Phosphatidylinositol 3–kinase/Akt signaling pathway in the anti-proliferative actions of dehydroepiandrosterone
  2107. Identification of transcription factor binding sites upstream of human genes regulated by the Phosphatidylinositol 3–kinase and MEK/ERK signaling pathways
  2108. Up-regulation of endothelial nitric oxide synthase via Phosphatidylinositol 3–kinase pathway contributes to ischemic tolerance in the CA1 subfield of gerbil …
  2109. TRAIL-induced apoptosis in human vascular endothelium is regulated by Phosphatidylinositol 3–kinase/Akt through the short form of cellular FLIP and Bcl-2
  2110. Topical treatment with inhibitors of the Phosphatidylinositol 3′-kinase/Akt and Raf/mitogen-activated protein kinase kinase/extracellular signal-regulated kinase …
  2111. Nitric oxide induces hypoxia-inducible factor 1 activation that is dependent on MAPK and Phosphatidylinositol 3–kinase signaling
  2112. A hypoxia-independent hypoxia-inducible factor-1 activation pathway induced by Phosphatidylinositol–3 kinase/Akt in HER2 overexpressing cells
  2113. IL-2 increases human telomerase reverse transcriptase activity transcriptionally and posttranslationally through Phosphatidylinositol 3′-kinase/Akt, heat shock protein …
  2114. FasL (CD95L/APO-1L) resistance of neurons mediated by Phosphatidylinositol 3–kinase-Akt/protein kinase B-dependent expression of lifeguard/neuronal membrane …
  2115. A role for Phosphatidylinositol 3–kinase in TCR-stimulated ERK activation leading to paxillin phosphorylation and CTL degranulation
  2116. Systematic evaluation of anti-apoptotic growth factor signaling in vascular smooth muscle cells: only Phosphatidylinositol 3′-kinase is important
  2117. Neuroprotective effects of the synthetic cannabinoid HU-210 in primary cortical neurons are mediated by Phosphatidylinositol 3–kinase/AKT signaling
  2118. Restoration of SHIP activity in a human leukemia cell line downregulates constitutively activated Phosphatidylinositol 3–kinase/Akt/GSK-3β signaling and leads to an …
  2119. Trophic signals acting via Phosphatidylinositol–3 kinase are required for normal pre-implantation mouse embryo development
  2120. Human mesothelioma cells exhibit tumor cell–specific differences in Phosphatidylinositol 3–kinase/AKT activity that predict the efficacy of Onconase
  2121. … lipoprotein inhibits thrombin-induced endothelial tissue factor expression through inhibition of RhoA and stimulation of Phosphatidylinositol 3–kinase but not Akt …
  2122. Inhibition of Phosphatidylinositol 3–kinase-and ERK MAPK-regulated protein synthesis reveals the pro-apoptotic properties of CD40 ligation in carcinoma cells
  2123. HIV‐1 gp120‐induced TNF‐α production by primary human macrophages is mediated by Phosphatidylinositol‐3 (PI‐3) kinase and mitogen‐activated protein (MAP) …
  2124. … proliferator-activated receptor-γ by rosiglitazone protects human islet cells against human islet amyloid polypeptide toxicity by a Phosphatidylinositol 3′-kinase …
  2125. A linear signal transduction pathway involving Phosphatidylinositol 3–kinase, protein kinase Cϵ, and MAPK in mesangial cells regulates interferon-γ-induced …
  2126. Inhibition of Phosphatidylinositol 3–kinase/Akt and histone deacetylase activity induces apoptosis in non–small cell lung cancer in vitro and in vivo
  2127. Interaction and functional analyses of human VPS34/p150 Phosphatidylinositol 3‐kinase complex with Rab7
  2128. The pro-inflammatory mediator leukotriene D4 induces Phosphatidylinositol 3–kinase and Rac-dependent migration of intestinal epithelial cells
  2129. … -Induced Oocyte Maturation in Atlantic Croaker (Micropogonias undulatus) Is Dependent on Activation of the Phosphatidylinositol 3–kinase/Akt Signal Transduction …
  2130. Inhibition of the Phosphatidylinositol 3′-kinase signaling pathway leads to decreased insulin-stimulated adiponectin secretion from 3T3-L1 adipocytes
  2131. Treating breast cancer through novel inhibitors of the Phosphatidylinositol 3‘-kinase pathway
  2132. Phosphatidylinositol 3‐kinase and Akt participate in the FSH‐induced meiotic maturation of mouse oocytes
  2133. Neurofibromatosis 2 (NF2) tumor suppressor merlin inhibits Phosphatidylinositol 3–kinase through binding to PIKE-L
  2134. Activation of Phosphatidylinositol 3–kinase, Akt, and mammalian target of rapamycin is necessary for hypoxia-induced pulmonary artery adventitial fibroblast …
  2135. The magnitude of Akt/Phosphatidylinositol 3′-kinase proliferating signaling is related to CD45 expression in human myeloma cells
  2136. Response of Non–Small Cell Lung Cancer Cells to the Inhibitors of Phosphatidylinositol 3–kinase/Akt- and MAPK kinase 4/c-Jun NH2-Terminal kinase Pathways …
  2137. RhoA activation mediates Phosphatidylinositol 3–kinase–dependent proliferation of human vascular endothelial cells: an alloimmune mechanism of chronic allograft …
  2138. Insulin-like growth factor 1 inhibits extracellular signal-regulated kinase to promote neuronal survival via the Phosphatidylinositol 3–kinase/protein kinase A/c-Raf …
  2139. … substrate metabolism of mouse cumulus-oocyte complexes: response to follicle-stimulating hormone is mediated by the Phosphatidylinositol 3–kinase pathway and is …
  2140. A Rac1/Phosphatidylinositol 3–kinase/Akt3 anti-apoptotic pathway, triggered by AlsinLF, the product of the ALS2 gene, antagonizes Cu/Zn-superoxide …
  2141. Protein phosphatase-2Cα as a positive regulator of insulin sensitivity through direct activation of Phosphatidylinositol 3–kinase in 3T3-L1 adipocytes
  2142. Suppression of Phosphatidylinositol 3–kinase/Akt signaling pathway is a determinant of the sensitivity to a novel histone deacetylase inhibitor, FK228, in lung …
  2143. Phosphatidylinositol 3–kinase signaling is involved in neurogenesis during Xenopus embryonic development
  2144. Phosphatidylinositol‐3 kinase is distinctively required for µ‐, but not κ‐opioid receptor‐induced activation of c‐Jun N‐terminal kinase
  2145. AMPA protects cultured neurons against glutamate excitotoxicity through a Phosphatidylinositol 3‐kinase‐dependent activation in extracellular signal‐regulated …
  2146. N-WASP and WAVE2 acting downstream of Phosphatidylinositol 3–kinase are required for myogenic cell migration induced by hepatocyte growth factor
  2147. Differential sensitivity of Phosphatidylinositol 3–kinase p110γ to isoforms of G protein βγ dimers
  2148. Epidermal growth factor stimulation of RPE cell survival: contribution of Phosphatidylinositol 3–kinase and mitogen-activated protein kinase pathways
  2149. PWT-458, a novel pegylated-17-hydroxywortmannin, inhibits Phosphatidylinositol 3–kinase signaling and suppresses growth of solid tumors
  2150. Phosphatidylinositol 3–kinase/Akt induced by erythropoietin renders the erythroid differentiation factor GATA-1 competent for TIMP-1 gene transactivation
  2151. Post-ischemic cardioprotection by A2A adenosine receptors: dependent of Phosphatidylinositol 3–kinase pathway
  2152. Calorie restriction increases the ratio of Phosphatidylinositol 3–kinase catalytic to regulatory subunits in rat skeletal muscle
  2153. nitric oxide triggers the Phosphatidylinositol 3–kinase/Akt survival pathway in insulin-producing RINm5F cells by arousing Src to activate insulin receptor substrate-1
  2154. Phosphatidylinositol 3–kinase regulates thymic exit
  2155. … Group A2 Potentiates Genotoxic Stress in Part through the Modulation of Basal and DNA Damage–Dependent Phosphatidylinositol 3–kinase–Related Protein kinase …
  2156. Dynamic reorganization of the astrocyte actin cytoskeleton elicited by cAMP and PACAP: a role for Phosphatidylinositol 3‐kinase inhibition
  2157. Pulmonary surfactant protein A activates a Phosphatidylinositol 3–kinase/calcium signal transduction pathway in human macrophages: participation in the up …
  2158. Novel mechanism of interaction of p85 subunit of Phosphatidylinositol 3–kinase and ErbB3 receptor-derived phosphotyrosyl peptides
  2159. Role for the pleckstrin homology domain-containing protein CKIP-1 in Phosphatidylinositol 3–kinase-regulated muscle differentiation
  2160. VEGF165 and angiopoietin-1 decreased myocardium infarct size through Phosphatidylinositol–3 kinase and Bcl-2 pathways
  2161. Hypothalamic Phosphatidylinositol 3‐kinase‐phosphodiesterase 3B‐cyclic AMP pathway of leptin signalling is impaired following chronic central leptin infusion
  2162. Akt2, Phosphatidylinositol 3–kinase, and PTEN are in lipid rafts of intestinal cells: role in absorption and differentiation
  2163. CD40/CD40 homodimers are required for CD40-induced Phosphatidylinositol 3–kinase-dependent expression of B7. 2 by human B lymphocytes
  2164. A permissive role for Phosphatidylinositol 3–kinase in the Stat5-mediated expression of cyclin D2 by the interleukin-2 receptor
  2165. Epidermal growth factor–induced cyclooxygenase-2 expression is mediated through Phosphatidylinositol–3 kinase, not mitogen-activated protein/extracellular signal …
  2166. The Phosphatidylinositol 3–kinase/protein kinase B signaling pathway is activated by lipoteichoic acid and plays a role in Kupffer cell production of interleukin-6 (IL-6) …
  2167. Differential regulation of Phosphatidylinositol 3–kinase/Akt, mitogen-activated protein kinase, and AMP-activated protein kinase pathways during menadione-induced …
  2168. Mammary epithelial-mesenchymal interaction regulates fibronectin alternative splicing via Phosphatidylinositol 3–kinase
  2169. Costimulation by CD137/4–1BB inhibits T cell apoptosis and induces Bcl‐xL and c‐FLIPshort via Phosphatidylinositol 3‐kinase and AKT/protein kinase B
  2170. A specific antagonist of the p110δ catalytic component of Phosphatidylinositol 3′-kinase, IC486068, enhances radiation-induced tumor vascular destruction
  2171. The role of phospholipase C and Phosphatidylinositol 3–kinase in vascular smooth muscle cell migration and proliferation
  2172. … hydroxy estradiol induces expression of hypoxia-inducible factor 1α and vascular endothelial growth factor A through Phosphatidylinositol 3–kinase/Akt/FRAP pathway …
  2173. … class I antibodies confers resistance to endothelial cells against antibody complement‐mediated lysis by regulating Bad through the Phosphatidylinositol 3‐kinase/Akt …
  2174. Calcium-sensing receptor induces proliferation through p38 mitogen-activated protein kinase and Phosphatidylinositol 3–kinase but not extracellularly regulated …
  2175. SH2-B promotes insulin receptor substrate 1 (IRS1)-and IRS2-mediated activation of the Phosphatidylinositol 3–kinase pathway in response to leptin
  2176. The mammalian target of rapamycin-p70 ribosomal S6 kinase but not Phosphatidylinositol 3–kinase-Akt signaling is responsible for fibroblast growth factor-9 …
  2177. … -induced signaling pathway in endothelial cells resulting in the overexpression of vascular endothelial growth factor involves Ras and Phosphatidylinositol 3–kinase
  2178. Low [Mg2+]e Enhances Arterial Spontaneous Tone via Phosphatidylinositol 3–kinase in DOCA-Salt Hypertension
  2179. Inhibition of either Phosphatidylinositol 3–kinase/Akt or the mitogen/extracellular-regulated kinase, MEK/ERK, signaling pathways suppress growth of breast cancer …
  2180. Phosphatidylinositol 3–kinase (PI-3K)/Akt but not PI-3K/p70 S6 kinase signaling mediates IGF-1-promoted lens epithelial cell survival
  2181. … -δ12, 14-prostaglandin J2 inhibits the inflammatory response in primary rat astrocytes via down-regulating multiple steps in Phosphatidylinositol 3–kinase-akt-NF-κB …
  2182. The bile acid tauroursodeoxycholic acid modulates phosphorylation and translocation of bad via Phosphatidylinositol 3–kinase in glutamate-induced apoptosis of rat …
  2183. Comparison of Phosphatidylinositol–3–kinase signalling within a panel of human colorectal cancer cell lines with mutant or wild-type PIK3CA
  2184. Gαq inhibits cardiac L-type Ca2+ channels through Phosphatidylinositol 3–kinase
  2185. The influence of Phosphatidylinositol 3‐kinase/Akt pathway on the ischemic injury during rat liver graft preservation
  2186. … ‐stimulating factor‐, or IL‐3‐dependent survival of macrophages, but not proliferation, requires the expression of p21Waf1 through the Phosphatidylinositol 3‐kinase …
  2187. RhoA controls myoblast survival by inducing the Phosphatidylinositol 3‐kinase‐Akt signaling pathway
  2188. Functional integrity of nuclear factor κB, Phosphatidylinositol 3′-kinase, and mitogen-activated protein kinase signaling allows tumor necrosis factor α-evoked Bcl-2 …
  2189. Phosphatidylinositol 3–kinase, phosphoinositide-specific phospholipase-Cγ and protein kinase-C signal myelin phagocytosis mediated by complement receptor-3 …
  2190. M-CSF stimulated differentiation requires persistent MEK activity and MAPK phosphorylation independent of Grb2–Sos association and Phosphatidylinositol 3–kinase …
  2191. … Aminoimidazole-4-carboxamide riboside suppresses lipopolysaccharide-induced TNF-α production through inhibition of Phosphatidylinositol 3–kinase/Akt activation in …
  2192. Activation of nuclear factor kappa B by diesel exhaust particles in mouse epidermal cells through Phosphatidylinositol 3–kinase/Akt signaling pathway
  2193. Phosphatidylinositol 3–kinase is a determinant of responsiveness to B cell antigen receptor-mediated Epstein-Barr virus activation
  2194. Phosphatidylinositol 3–kinase inhibitors reveal a unique mechanism of enhancing insulin secretion in 832/13 rat insulinoma cells
  2195. The integrin β1 subunit transmembrane domain regulates Phosphatidylinositol 3–kinase-dependent tyrosine phosphorylation of Crk-associated substrate
  2196. Integrin activation by bacterial fimbriae through a pathway involving CD14, Toll‐like receptor 2, and Phosphatidylinositol‐3‐kinase
  2197. cAMP-stimulated Na+ transport in H441 distal lung epithelial cells: role of PKA, Phosphatidylinositol 3–kinase, and sgk1
  2198. Roles of Phosphatidylinositol 3′-kinase and mammalian target of rapamycin/p70 ribosomal protein S6 kinase in K-Ras-mediated transformation of intestinal epithelial …
  2199. … regulation of human mucin MUC4 by bile acids in oesophageal cancer cells is promoter-dependent and involves activation of the Phosphatidylinositol 3–kinase …
  2200. … cells via MyD88, interleukin-1 receptor-associated kinase, tumor necrosis factor receptor-associated factor 6, c-Src, Phosphatidylinositol 3–kinase, Akt, c-Jun …
  2201. … Pathway Leads to Phosphorylation of Insulin Receptor Substrate-1 on Ser307 and Ser612 and Impairs the Phosphatidylinositol 3–kinase/Akt/Mammalian Target of …
  2202. Phosphatidylinositol 3–kinase inhibitors are a triple threat to ovarian cancer
  2203. Diosgenin induces hypoxia-inducible factor-1 activation and angiogenesis through estrogen receptor-related Phosphatidylinositol 3–kinase/Akt and p38 mitogen …
  2204. Role of Phosphatidylinositol 3–kinase-γ in mediating lung neutrophil sequestration and vascular injury induced by E. coli sepsis
  2205. Aquaporin-2 is retrieved to the apical storage compartment via early endosomes and Phosphatidylinositol 3–kinase-dependent pathway
  2206. Regulation of granulocyte apoptosis by Phosphatidylinositol 3–kinase
  2207. … in human breast cancer cells does not rely on direct induction of mitogen-activated protein kinase/extracellularly regulated kinase or Phosphatidylinositol 3–kinase
  2208. Phosphatidylinositol 3–kinase-dependent signaling modulates taurochenodeoxycholic acid-induced liver injury and cholestasis in perfused rat livers
  2209. Control of cell size through phosphorylation of upstream binding factor 1 by nuclear Phosphatidylinositol 3–kinase
  2210. Activation of Phosphatidylinositol 3‐kinase and c‐Jun‐N‐terminal kinase cascades enhances NF‐κB‐dependent gene transcription in BCG‐stimulated macrophages …
  2211. Mouse embryonic stem cells and preimplantation embryos require signaling through the Phosphatidylinositol 3‐kinase pathway to suppress apoptosis
  2212. Opposing roles of endothelial and smooth muscle Phosphatidylinositol 3–kinase in vasoconstriction: effects of rho-kinase and hypertension
  2213. … -independent activation of GABAergic neurotransmission and receptor-dependent nontranscriptional activation of Phosphatidylinositol 3–kinase/protein kinase Akt …
  2214. Muscarinic M2 receptor stimulation of Cav1. 2b requires Phosphatidylinositol 3–kinase, protein kinase C, and c-Src
  2215. Vav-dependent and vav-independent Phosphatidylinositol 3–kinase activation in murine B cells determined by the nature of the stimulus
  2216. … of the heavy chain of tetanus toxin rescues cerebellar granule neurones from apoptotic death: involvement of Phosphatidylinositol 3‐kinase and mitogen‐activated …
  2217. Phosphatidylinositol 3–kinase/Akt pathway mediates heme oxygenase-1 regulation by lipopolysaccharide.
  2218. Possible involvement of Phosphatidylinositol 3–kinase/Akt pathway in insulin-like growth factor-I-induced alkaline phosphatase activity in osteoblasts
  2219. Deregulation of the Phosphatidylinositol–3 kinase signaling cascade is associated with neurodegeneration in Npc1−/− mouse brain
  2220. Hydrogen peroxide and epidermal growth factor activate Phosphatidylinositol 3–kinase and increase sodium transport in A6 cell monolayers
  2221. Involvement of Phosphatidylinositol 3–kinase and insulin-like growth factor-I in YXLST-mediated neuroprotection
  2222. Survivin contributes to the anti-apoptotic activities of transforming growth factor alpha in mouse blastocysts through Phosphatidylinositol 3‘-kinase pathway
  2223. … inhibits β-amyloid peptide (1-42)-mediated hippocampal neuronal apoptosis through activation of mitogen-activated protein kinase and Phosphatidylinositol 3–kinase …
  2224. Phosphatidylinositol 3‐kinase inhibition enhances human sperm motility and sperm–zona pellucida binding
  2225. Modulation of Phosphatidylinositol 3–kinase signaling reduces intimal hyperplasia in aortocoronary saphenous vein grafts
  2226. α1A-Adrenoceptors Activate Glucose Uptake in L6 Muscle Cells through a Phospholipase C-, Phosphatidylinositol–3 kinase-, and Atypical Protein kinase C …
  2227. Differential effects of P2Y1 and P2Y12 nucleotide receptors on ERK1/ERK2 and Phosphatidylinositol 3‐kinase signalling and cell proliferation in serum‐deprived …
  2228. … via modulation of involucrin and transglutaminase expression through the integrin α3β1 and the Phosphatidylinositol 3–kinase/Akt signaling pathway
  2229. Phosphatidylinositol 3–kinase modulates vascular smooth muscle contraction by calcium and myosin light chain phosphorylation-independent and-dependent …
  2230. … -1 and HNF-4 and the coactivator p300 are involved in insulin-regulated glucokinase gene expression via the Phosphatidylinositol 3–kinase/protein kinase B …
  2231. Mammalian target of rapamycin and 3–Phosphatidylinositol 3–kinase pathway inhibition enhances growth inhibition of transforming growth factor-β1 in prostate cancer …
  2232. Fibroblast growth factor-2 induces osteoblast survival through a Phosphatidylinositol 3–kinase-dependent,-β-catenin-independent signaling pathway
  2233. Activation of MMP-2 in response to vascular injury is mediated by Phosphatidylinositol 3–kinase-dependent expression of MT1-MMP
  2234. Adhesion-independent α6β4 integrin clustering is mediated by Phosphatidylinositol 3–kinase
  2235. … -induced integrin affinity maturation promotes recruitment of αVβ3 integrin to focal adhesions in endothelial cells: Evidence for a role of Phosphatidylinositol 3–kinase …
  2236. NGF-induced Phosphatidylinositol 3–kinase signaling pathway prevents thapsigargin-triggered ER stress-mediated apoptosis in PC12 cells
  2237. Optimal windows of statin use for immediate infarct limitation: 5′-nucleotidase as another downstream molecule of Phosphatidylinositol 3–kinase
  2238. Complementation of human papillomavirus type 16 E6 and E7 by Jagged1-specific Notch1-Phosphatidylinositol 3–kinase signaling involves pleiotropic oncogenic …
  2239. Phosphatidylinositol 3–kinase activator reduces motor neuronal cell death induced by G93A or A4V mutant SOD1 gene
  2240. Transient Phosphatidylinositol 3–kinase inhibition protects immature primary cortical neurons from oxidative toxicity via suppression of extracellular signal …
  2241. Exogenous tissue inhibitor of metalloproteinase‐1 promotes endothelial cell survival through activation of the Phosphatidylinositol 3‐kinase/Akt pathway
  2242. Phosphatidylinositol 3–kinase activation is required for sulfonylurea stimulation of glucose transport in rat skeletal muscle
  2243. Enhancement of osteopontin expression in HepG2 cells by epidermal growth factor via Phosphatidylinositol 3–kinase signaling pathway
  2244. Cloning of Brassica napus phospholipase C2 (BnPLC2), Phosphatidylinositol 3–kinase (BnVPS34) and Phosphatidylinositol synthase1 (BnPtdIns S1)—comparative …
  2245. Biochemical and biological responses induced by coupling of Gab1 to Phosphatidylinositol 3–kinase in RET-expressing cells
  2246. … receptor β/δ (PPARβ/δ) increases the expression of prostaglandin E2 receptor subtype EP4: the roles of Phosphatidylinositol 3–kinase and CCAAT/enhancer …
  2247. Phosphatidylinositol 3–kinase p85α subunit-dependent interaction with BCR/ABL-related fusion tyrosine kinases: molecular mechanisms and biological …
  2248. α-Thrombin-mediated Phosphatidylinositol 3–kinase activation through release of Gβγ dimers from Gαq and Gαi2
  2249. Angiotensin II Regulation of the Na+ Pump Involves the Phosphatidylinositol–3 kinase and p42/44 Mitogen-Activated Protein kinase Signaling Pathways in Vascular …
  2250. Resensitization of P2Y Receptors by Growth Factor–Mediated Activation of the Phosphatidylinositol–3 kinase in Retinal Glial Cells
  2251. Upregulated function of Phosphatidylinositol‐3‐kinase in genetically hypertensive rats: a moderator of arterial hypercontractility
  2252. Adenosine A2A receptor facilitates calcium-dependent protein secretion through the activation of protein kinase A and Phosphatidylinositol–3 kinase in PC12 cells
  2253. … , a diterpenoid triepoxide, induces antitumor proliferation via activation of c-Jun NH2-terminal kinase 1 by decreasing Phosphatidylinositol 3–kinase activity in human …
  2254. Leptin decreases renal medullary Na (+), K (+)-ATPase activity through Phosphatidylinositol 3–kinase dependent mechanism.
  2255. Differential involvement of Phosphatidylinositol 3–kinase and p42/p44 mitogen activated protein kinase pathways in brain-derived neurotrophic factor-induced trophic …
  2256. … epidermal growth factor‐like growth factor stimulates cell proliferation in cerebral cortical cultures through Phosphatidylinositol 3′‐kinase and mitogen‐activated …
  2257. Two distinct regulatory mechanisms of neurotransmitter release by Phosphatidylinositol 3‐kinase
  2258. AND-34 Activates Phosphatidylinositol 3–kinase and Induces Anti-Estrogen Resistance in a SH2 and GDP Exchange Factor–Like Domain-Dependent Manner
  2259. Calcium oscillation and Phosphatidylinositol 3–kinase positively regulate integrin αIIbβ3-mediated outside-in signaling
  2260. Overexpression of the N-terminal end of the p55γ regulatory subunit of Phosphatidylinositol 3–kinase blocks cell cycle progression in gastric carcinoma cells
  2261. Inhibition of Phosphatidylinositol–3–kinase synergizes with gemcitabine in low-passage tumor cell lines correlating with Bax translocation to the mitochondria
  2262. … neurones by brain‐derived neurotrophic factor and Raf‐1 protein kinase: role of extracellular signal‐regulated protein kinase and Phosphatidylinositol 3‐kinase
  2263. Phosphatidylinositol–3–kinase activation mediates proline-rich tyrosine kinase 2 phosphorylation and recruitment to β1-integrins in human CD34+ cells
  2264. Angiopoietin-1 attenuates H2O2-induced SEK1/JNK phosphorylation through the Phosphatidylinositol 3–kinase/Akt pathway in vascular endothelial cells
  2265. RNA interference, A potential strategy for isoform-specific Phosphatidylinositol 3–kinase targeted therapy in ovarian cancer
  2266. Expression of insulin receptor substrates 1-3, glucose transporters GLUT-1-4, signal regulatory protein 1α, Phosphatidylinositol 3–kinase and protein kinase B at the …
  2267. Phosphatidylinositol 3–kinase regulates Ca2+ signaling in pancreatic acinar cells through inhibition of sarco(endo)plasmic reticulum Ca2+-ATPase
  2268. In vitro metabolism of the Phosphatidylinositol 3–kinase inhibitor, wortmannin, by carbonyl reductase
  2269. Interleukin-2-induced survival of natural killer (NK) cells involving Phosphatidylinositol–3 kinase-dependent reduction of ceramide through acid sphingomyelinase …
  2270. T cell leukemia-1 modulates TCR signal strength and IFN-γ levels through Phosphatidylinositol 3–kinase and protein kinase C pathway activation
  2271. Adenosine A3 receptor-mediated regulation of p38 and extracellular-regulated kinase ERK1/2 via Phosphatidylinositol–3′-kinase
  2272. Negative Feedback Regulation of Phosphatidylinositol 3‐kinase/Akt Pathway by Over‐Expressed Cyclooxygenase‐2 in Human Epidermal Cancer Cells
  2273. Group IB secretory phospholipase A2 promotes matrix metalloproteinase-2-mediated cell migration via the Phosphatidylinositol 3–kinase and Akt pathway
  2274. Phosphatidylinositol 3–kinase/Akt-dependent and-independent protection against apoptosis in normal human melanocytes
  2275. Generation and functional in vivo characterization of a lipid kinase defective Phosphatidylinositol 3–kinase Vps34p of Candida albicans
  2276. Phosphatidylinositol‐3 kinase inhibitors reproduce the selective antiproliferative effects of imatinib on chronic myeloid leukaemia progenitor cells
  2277. … adhesion is controlled by src-kinases, whereas PF-4–mediated exocytosis requires the additional activation of p38 MAP kinase and Phosphatidylinositol 3–kinase
  2278. Prolactin and heregulin override DNA damage-induced growth arrest and promote Phosphatidylinositol–3 kinase-dependent proliferation in breast cancer cells
  2279. Hemangiopoietin inhibits apoptosis of MO7e leukemia cells through Phosphatidylinositol 3–kinase–AKT pathway
  2280. Intrinsic regulation of the interactions between the SH3 domain of p85 subunit of Phosphatidylinositol–3 kinase and the protein network of BCR/ABL oncogenic …
  2281. Akt-dependent cell size regulation by the adhesion molecule on glia occurs independently of Phosphatidylinositol 3–kinase and Rheb signaling
  2282. Phosphatidylinositol 3–kinase regulates early differentiation in human laryngeal keratinocytes
  2283. Raloxifene improves coronary perfusion, cardiac contractility, and myocardial metabolism in the ischemic heart: role of Phosphatidylinositol 3–kinase/Akt pathway
  2284. Arrest of human lung fibroblasts in G2 phase after irradiation is regulated by converging Phosphatidylinositol–3 kinase and β1-integrin signaling in vitro
  2285. … M stimulation of proliferation of prostate cancer 22Rv1 cells through the signaling pathways of p38 mitogen‐activated protein kinase and Phosphatidylinositol 3‐kinase
  2286. … of the insulin-like growth factor-I receptor by angiotensin II mediates downstream signaling from the angiotensin II type 1 receptor to Phosphatidylinositol 3–kinase
  2287. Skeletal muscle insulin signaling defects downstream of Phosphatidylinositol 3–kinase at the level of Akt are associated with impaired nonoxidative glucose disposal in …
  2288. … interleukin-1 receptor-associated kinase degradation in response to lipopolysaccharide: involvement of CD14/TLR4, CR3, and Phosphatidylinositol 3–kinase
  2289. Constitutively activated Phosphatidylinositol 3–kinase primes platelets from patients with chronic myelogenous leukemia for thrombopoietin-induced aggregation
  2290. Enhanced v-Src-induced oncogenic transformation in the absence of focal adhesion kinase is mediated by Phosphatidylinositol 3–kinase
  2291. Phosphorylation of glycosyl-Phosphatidylinositol by Phosphatidylinositol 3–kinase changes its properties as a substrate for phospholipases
  2292. Kainate mediates nuclear factor-kappa B activation in hippocampus via Phosphatidylinositol–3 kinase and extracellular signal-regulated protein kinase
  2293. … apoptosis by GM‐CSF as a result of temporary suppression of FADD recruitment in neutrophils: evidence implicating Phosphatidylinositol 3‐kinase and MEK1‐ERK1 …
  2294. Balamuthia mandrillaris stimulates interleukin-6 release in primary human brain microvascular endothelial cells via a Phosphatidylinositol 3–kinase-dependent …
  2295. Suppression of a Phosphatidylinositol 3–kinase signal by a specific spliced variant of Drosophila PTEN
  2296. Phosphatidylinositol 3–kinase-dependent mitogen-activated protein/extracellular signal-regulated kinase kinase 1/2 and NF-κB signaling pathways are required for B …
  2297. … by granulocyte colony-stimulating factor, granulocyte-macrophage colony-stimulating factor, and tumor necrosis factor α: role of Phosphatidylinositol 3–kinase
  2298. Direct activation of telomerase by GH via Phosphatidylinositol 3′-kinase
  2299. The production of IL-1 receptor antagonist in IFN-β-stimulated human monocytes depends on the activation of Phosphatidylinositol 3–kinase but not of STAT1
  2300. Defective Activation of Protein kinase Cz in Muscle by Insulin and Phosphatidylinositol–3,4,5,-(PO4)3 in Obesity and Polycystic Ovary Syndrome
  2301. LY303511 (2-piperazinyl-8-phenyl-4H-1-benzopyran-4-one) acts via Phosphatidylinositol 3–kinase-independent pathways to inhibit cell proliferation via mammalian …
  2302. Carbamazepine enhances the activity of glutamate transporter type 3 via Phosphatidylinositol 3–kinase
  2303. Inhibition of Phosphatidylinositol 3–kinase/Protein kinase B Signaling Is Not Sufficient to Account for Indole-3-Carbinol–Induced Apoptosis in Some Breast and …
  2304. Phosphatidylinositol 3–kinase VPS34 of Candida albicans is involved in filamentous growth, secretion of aspartic proteases, and intracellular detoxification
  2305. … epidermal growth factor-like growth factor inhibits cytokine-induced NF-κB activation and nitric oxide production via activation of the Phosphatidylinositol 3–kinase …
  2306. … of ovarian insulin-like growth factor-binding protein-3 transcription requires a TATA box-binding protein and the protein kinase A and Phosphatidylinositol–3 kinase …
  2307. CD4+ CD25+ regulatory T cells attenuate the Phosphatidylinositol 3–kinase/Akt pathway in antigen-primed immature CD8+ CTLs during functional maturation
  2308. B cell receptor (BCR) cross-talk: IL-4 creates an alternate pathway for BCR-induced ERK activation that is Phosphatidylinositol 3–kinase independent
  2309. Oxidized low‐density lipoprotein‐induced apoptosis is attenuated by insulin‐activated Phosphatidylinositol 3‐kinase/Akt through p38 mitogen‐activated protein kinase
  2310. … signaling by the novel compound 3-Cl-AHPC involves increased EGFR proteolysis and accompanying decreased Phosphatidylinositol 3–kinase and AKT kinase …
  2311. Growth factors change nuclear distribution of estrogen receptor-α via mitogen-activated protein kinase or Phosphatidylinositol 3–kinase cascade in a human breast …
  2312. Protein kinase C modulates negatively the hepatocyte growth factor-induced migration, integrin expression and Phosphatidylinositol 3–kinase activation
  2313. LY294002 inhibits monocyte chemoattractant protein-1 expression through a Phosphatidylinositol 3–kinase-independent mechanism
  2314. Phosphatidylinositol–3–kinase regulates PKCθ activity in cytotoxic T cells
  2315. Assay and Stimulation of the Rab5 GTPase by the p85α Subunit of Phosphatidylinositol 3‐kinase
  2316. … -like growth factor (IGF) binding protein-3 synthesis by IGF-I and transforming growth factor-α is mediated by both Phosphatidylinositol–3 kinase and mitogen-activated …
  2317. … phospholipase D pathway stimulated by formyl-methionyl-leucyl-phenylalanine in human neutrophils. Involvement of EP2 receptors and Phosphatidylinositol 3–kinase …
  2318. Integrated pharmacological preconditioning and memory of cardioprotection: role of protein kinase C and Phosphatidylinositol 3–kinase
  2319. Requirements for pYXXM motifs in Cbl for binding to the p85 subunit of Phosphatidylinositol 3–kinase and Crk, and activation of atypical protein kinase C and glucose …
  2320. Hedamycin, a DNA alkylator, induces γH2AX and chromosome aberrations: Involvement of Phosphatidylinositol 3–kinase–related kinases and DNA replication fork …
  2321. Insulin-like growth factor binding protein-3 stimulates Phosphatidylinositol 3–kinase in MCF-7 breast carcinoma cells
  2322. Measurement of the Interaction of the p85α Subunit of Phosphatidylinositol 3‐kinase with Rab5
  2323. Role of the Phosphatidylinositol 3–kinase and mitogen-activated protein kinase pathways in the secretion of tumor necrosis factor-α and interleukin-10 by the PPD …
  2324. Possible involvement of Phosphatidylinositol 3–kinase/Akt signal pathway in vasopressin-induced HSP27 phosphorylation in aortic smooth muscle A10 cells
  2325. Inhibition of Phosphatidylinositol–3–kinase causes cell death through a protein kinase B (PKB)-dependent mechanism and growth arrest through a PKB-independent …
  2326. Leptin regulates insulin sensitivity via Phosphatidylinositol–3-OH kinase signaling in mediobasal hypothalamic neurons
  2327. CD40-dependent activation of Phosphatidylinositol 3–kinase/AKT pathway inhibits apoptosis of human cultured mesangial cells induced by oxidized LDL
  2328. Differential regulation of the regulatory subunits for Phosphatidylinositol 3–kinase in response to motor nerve injury
  2329. Nerve growth factor restores p53 function in pituitary tumor cell lines via trkA-mediated activation of Phosphatidylinositol 3–kinase
  2330. Ethanol impairs insulin’s actions through Phosphatidylinositol 3–kinase
  2331. Alterations in lens protein tyrosine phosphorylation and Phosphatidylinositol 3–kinase signaling during selenite cataract formation
  2332. Activation of Phosphatidylinositol 3–kinase-protein kinase B (PI3K-PKB) induced by 17beta-estradiol in endometrial carcinoma cell (Ishikawa)
  2333. Phosphatidylinositol 3‐kinase is required for the transcriptional activation of cyclin D2 in BCR activated primary mouse B lymphocytes
  2334. … factor mediates Porphyromonas gingivalis lipopolysaccharide interference with salivary mucin synthesis via Phosphatidylinositol 3–kinase-dependent constitutive nitric …
  2335. … blue 2 inhibition of cyclic AMP-dependent differentiation of rat C6 glioma cells by purinergic receptor-independent inactivation of Phosphatidylinositol 3–kinase
  2336. … -like protein tyrosine phosphatase α, Src, and Rho to increase prolactin gene expression through a final Phosphatidylinositol 3–kinase/cytoskeletal pathway that is …
  2337. Insulin-like growth factor I induces preferential degradation of insulin receptor substrate-2 through the Phosphatidylinositol 3–kinase pathway in human neuroblastoma …
  2338. Inhibition of Phosphatidylinositol–3–kinase Enhances Insulin Stimulation of Insulin Receptor Substrate 1 Tyrosine Phosphorylation and Extracellular Signal-Regulated …
  2339. Angiopoietin-1 reduces iopromide-induced endothelial cell apoptosis through activation of Phosphatidylinositol 3‘-kinase/p70 S6 kinase.
  2340. Insulin substrates 1 and 2 are corequired for activation of atypical protein kinase C and Cbl-dependent Phosphatidylinositol 3–kinase during insulin action in …
  2341. The Phosphatidylinositol 3–kinase Vps34p of the human pathogenic yeast Candida albicans is a multifunctional protein that interacts with the putative vacuolar H+ …
  2342. Phosphatidylinositol 3‐kinase and ERK1/2 are not involved in adenosine A1, A2A or A3 receptor‐mediated preconditioning in rat ventricle strips
  2343. … activated receptor/(PPAR/) increases the expression of prostaglandin E2 receptor subtype EP4: the roles of Phosphatidylinositol 3–kinase and CCAAT/enhancer …
  2344. Impaired Activation of Protein kinase C-ζ by Insulin and Phosphatidylinositol–3,4,5-(PO4)3 in Cultured Preadipocyte-Derived Adipocytes and Myotubes of Obese …
  2345. A constituent of green tea, epigallocatechin-3-gallate, activates endothelial nitric oxide synthase by a Phosphatidylinositol–3-OH-kinase-, cAMP-dependent …
  2346. The role of Phosphatidylinositol–3 kinase in vanadate-promoted S phase entry
  2347. Phosphatidylinositol 3–kinase, phosphoinositides and apoptosis
  2348. ALCOHOLIC PANCREATIC FIBROSIS: ROLE OF THE Phosphatidylinositol–3 kinase (PI3-K) AND PROTEIN kinase C (PKC) PATHWAYS IN PANCREATIC …
  2349. Role of Phosphatidylinositol–3 kinase in regulation of differential sensitivity of melanoma cells to antitumor agents. A model for hormone resistance development in …
  2350. Differential Effects of Three Small Molecules Blocking Phosphatidylinositol–3 kinase or AKT in Hodgkin Disease Cell Lines: Induction of Apoptosis and Cell Cycle …
  2351. Role of Phosphatidylinositol–3–kinase and protein kinase Cζ in the adenylate cyclase signal mechanism of action of relaxin in muscle tissues of rats and mollusks
  2352. Novel expression patterns of Phosphatidylinositol 3‐hydroxy kinase in nodulated Medicago spp. plants
  2353. Adrenomedullin infusion attenuates myocardial ischemia/reperfusion injury through the Phosphatidylinositol 3–kinase/Akt-dependent pathway
  2354. Activation of the hexosamine pathway leads to phosphorylation of IRS-1 on Ser307 and Ser612 and impairs the Phosphatidylinositol 3–kinase/Akt/mTOR insulin …
  2355. Enhancement of susceptibility to Fas-mediated apoptosis in HL-60 cells through down-regulation of cellular FLICE-inhibitory protein by Phosphatidylinositol 3–kinase …
  2356. Role of extracellular signal‐regulated protein kinase and Phosphatidylinositol 3‐kinase in neuronal cell death and survival
  2357. Inhibition of Phosphatidylinositol 3–kinase activity blocks nuclear accumulation of protein kinase zetta during granulocytic differentiation of HL-60 cells
  2358. Leptin inhibits hypothalamic Npy and Agrp gene expression via a mechanism that requires Phosphatidylinositol 3-OH-kinase signaling
  2359. Physiological role of Vps34 Phosphatidylinositol 3–kinase in mammalian cells
  2360. Inhibition of Phosphatidylinositol 3–kinase causes apoptosis in retinoic acid-differentiated HL-60 leukemia cells
  2361. Phosphatidylinositol 3–kinase (PI3K) cascade is a novel signaling pathway to mediate inflammatory pain
  2362. Activation of the Phosphatidylinositol–3‘kinase pathway and DNA synthesis by a mutant insulin-like growth factor I receptor lacking the NPXY motif
  2363. Estrogen receptor (ER) α and ERβ are both expressed in human ejaculated spermatozoa: evidence of their direct interaction with Phosphatidylinositol–3-OH kinase/Akt …
  2364. A novel Phosphatidylinositol 3–kinase inhibitor, ZSTK474 exerted antitumor activity against human tumor xenografts by oral administration
  2365. Roles of Akt2 and the molecular balance of Phosphatidylinositol 3–kinase subunits in enhanced skeletal muscle insulin sensitivity with calorie restriction
  2366. Activation of Phosphatidylinositol 3–kinase, Akt and Mammalian Target of Rapamycin (mTOR) Is Necessary for Hypoxia-Induced Pulmonary Artery Adventitial …
  2367. Role of Phosphatidylinositol 3–kinase/AKT Pathway in Diffuse Large B-Cell Lymphoma Survival.
  2368. Research Capsule Phosphatidylinositol 3–kinase: A Novel Effector
  2369. Role of Phosphatidylinositol 3–kinase in platelet aggregation in type 1 diabetes mellitus
  2370. Role of Phosphatidylinositol 3–kinase in oxidative stress-induced disruption of tight junctions. Vol. 278 (2003) 49239-49245
  2371. Phosphatidylinositol 3–kinase p85 Subunit-Dependent Interaction with BCR/ABL: Molecular Mechanism and Biological Consequences.
  2372. Oxygen, hypoxia-inducible factors, and Phosphatidylinositol 3–kinase/Akt signaling in tumor growth and gene expression.
  2373. Atypical Protein kinase C (PKCλ/ζ) is a convergent downstream target of the insulin stimulated Phosphatidylinositol 3–kinase and TC10 signalling pathways
  2374. Type I Transforming Growth Factor ك Receptor Binds to and Activates Phosphatidylinositol 3–kinase
  2375. Specific Inhibition of p110δ Catalytic Subunit of Phosphatidylinositol 3‘-kinase With IC489666 Radiosensitizes Vascular Endothelium to Provide Improved Tumor …
  2376. Phosphatidylinositol 3–kinase activator reduces motor neuronal cell death induced by G93A or A4V mutant SOD1 gene
  2377. Expression and significance of Phosphatidylinositol 3–kinase in mammary atypical ductal hyperrlasia and cance
  2378. Augmentation in inhibitory effect of sodium butyrate by Phosphatidylinositol 3–kinase inhibition in the human cervical cancer cells
  2379. Role of Phosphatidylinositol 3–kinase in epinephrine and calcium ionophore, A 23187 induced platelet aggregation
  2380. THE ROLE OF Phosphatidylinositol 3 kinase IN THE INDUCTION OF LIPOPOLYSACCHARIDE TOLERANCE AND PRIMING TOSTAPHYLOCOCCUS …
  2381. UV-B Induced stimulation of Phosphatidylinositol 3–kinase in human fetal hepatocytes
  2382. The Association of the Phosphatidylinositol–3–kinase Pathway to Gleason Score, Prostate-specific Antigen and Pathologic Stage in Prostate Cancer
  2383. Bacterial Endotoxin and Staphylococcus aureus induced Tolerance and Priming, Implication of the Phosphatidylinositol–3 kinase Pathway: 262
  2384. Overexpression of the N-terminal end of the p55y regulatory subunit of Phosphatidylinositol 3–kinase blocks cell cycle progression in gastric carcinoma cells
  2385. Phosphatidylinositol 3–kinase and Protein kinase C as Molecular Determinants of Chemoresistance in Breast Cancer
  2386. Nicotinic Receptor Stimulation Blocks Neurotoxicity Induced by Amyloid-ß via the Phosphatidylinositol–3–kinase Cascade
  2387. … OF OOCYTES, SPERM-OOCYTE INTERACTIONS AND EARLY CLEAVAGE OF EMBRYOS IN MICE, ROLE OF Phosphatidylinositol 3–kinase, MOS, FAS-FAS …
  2388. P-selectin activates leukocyte integrin alphaMbeta2 by recruiting Phosphatidylinositol–3 kinase to p-selectin glycoprotein ligand-1 cytoplasmic domain through adaptor …
  2389. Mycobacteria-induced Interleukin-12 Expression by Human Monocyte-derived Macrophages Is Negatively Regulated by Phosphatidylinositol 3–kinase and ERK 1/2 …
  2390. … ‐, or IL‐3‐dependent survival of macrophages, but not proliferation, requires the expression of p21Waf1 through the Phosphatidylinositol 3‐kinase/Akt pathway (Vol …
  2391. Analysis of IRS-1-mediated Phosphatidylinositol 3–kinase activation in the adipose tissue of polycystic ovary syndrome patients complicated with insulin resistance
  2392. Stretch-induced retinal vascular endothelial growth factor expression is mediated by Phosphatidylinositol 3–kinase and protein kinase C (PKC)-ζ but not by stretch …
  2393. 459 EFFECT OF INSULIN ON ADIPONECTIN SECRETION FROM 3T3-L1 ADIPOCYTES IS Phosphatidylinositol 3–kinase DEPENDENT
  2394. … apoptosis by GM-CSF as a result of temporary suppression of FADD recruitment in neutrophils: evidence implicating Phosphatidylinositol 3–kinase and MEK1-ERK1/2 …
  2395. Relationship between neuroprotective effect of 17# beta#–estradiol and activity of Phosphatidylinositol—3—kinase
  2396. … by GM-CSF as a result of temporary suppression of FADD recruitment in neutrophils: evidence implicating Phosphatidylinositol 3–kinase and MEK1-ERK1/2 …
  2397. S 2-24: A protein kinase C superfamily member mediates invasive prostate cell growth downstream of activated Phosphatidylinositol 3–kinase
  2398. … stress protection and increased cell proliferation induced by the protein p8 in INS-1 beta cells via activation of the Phosphatidylinositol–3‘-kinase and MAP kinase …
  2399. AND-34-induced Rac activation and antiestrogen resistance in breast cancer requires Phosphatidylinositol 3–kinase
  2400. The inhibitory effect of dibutyryl cyclic AMP on docosahexaenoic acid-induced apoptosis in HL-60 cells through activation of the Phosphatidylinositol–3 kinase pathway
  2401. Cripto-1 Inhibits-Casein Expression in Mammary Epithelial Cells through a p21′-and Phosphatidylinositol 3‘-kinase-dependent Pathway1
  2402. … Factor 1 Induced Expression of Vascular Endothelial Growth Factor, Which Is Dependent on MAP kinase and Phosphatidylinositol 3–kinase Signaling in Human …
  2403. … -Induced Vascular Endothelial Growth Factor in Human Bone Marrow Stromal Cells, Which Is Involved in MAP kinase and Phosphatidylinositol 3–kinase …
  2404. Study of the regulation of Fab1p, a Phosphatidylinositol 3-phosphate 5 kinase in Saccharomyces cerevisiae
  2405. Characterisation of the Phosphatidylinositol–3-phosphate 5-kinase, Fab1, in Drosophila melanogaster
  2406. Phosphatidylinositol 3‐kinase inhibitors: promising drug candidates for cancer therapy
  2407. Cancer-specific mutations in Phosphatidylinositol 3–kinase
  2408. Antitumor activity of ZSTK474, a new Phosphatidylinositol 3–kinase inhibitor
  2409. Therapeutic potential of Phosphatidylinositol 3–kinase inhibitors in inflammatory respiratory disease
  2410. Phosphatidylinositol 3–kinase hyperactivation results in lapatinib resistance that is reversed by the mTOR/Phosphatidylinositol 3–kinase inhibitor NVP-BEZ235
  2411. Genetic alterations and their relationship in the Phosphatidylinositol 3–kinase/Akt pathway in thyroid cancer
  2412. ZSTK474 is an ATP‐competitive inhibitor of class I Phosphatidylinositol 3 kinase isoforms
  2413. Helical domain and kinase domain mutations in p110α of Phosphatidylinositol 3–kinase induce gain of function by different mechanisms
  2414. Effect of the Phosphatidylinositol 3–kinase/Akt pathway on influenza A virus propagation
  2415. Role of Phosphatidylinositol 3′-kinase/AKT pathway in diffuse large B-cell lymphoma survival
  2416. Beclin 1 forms two distinct Phosphatidylinositol 3–kinase complexes with mammalian Atg14 and UVRAG
  2417. Assortment of Phosphatidylinositol 3–kinase complexes—Atg14p directs association of complex I to the pre-autophagosomal structure in Saccharomyces cerevisiae
  2418. Bivalent role of the Phosphatidylinositol‐3‐kinase (PI3K) during influenza virus infection and host cell defence
  2419. Roles of Phosphatidylinositol 3–kinase in root hair growth
  2420. Role of Phosphatidylinositol 3–kinase activation on insulin action and its alteration in diabetic conditions
  2421. The Arabidopsis Phosphatidylinositol 3–kinase is important for pollen development
  2422. Artery/vein specification is governed by opposing Phosphatidylinositol–3 kinase and MAP kinase/ERK signaling
  2423. Cross-talk between the androgen receptor and the Phosphatidylinositol 3–kinase/Akt pathway in prostate cancer
  2424. Targeting the Phosphatidylinositol 3–kinase pathway in multiple myeloma
  2425. Clusterin activates survival through the Phosphatidylinositol 3–kinase/Akt pathway
  2426. Phosphatidylinositol 3–kinase inhibition by LY294002 radiosensitizes human cervical cancer cell lines
  2427. Regulation of hepatitis B virus replication by the Phosphatidylinositol 3–kinase-akt signal transduction pathway
  2428. Cytokine stimulation promotes glucose uptake via Phosphatidylinositol–3 kinase/Akt regulation of Glut1 activity and trafficking
  2429. Nutrients suppress Phosphatidylinositol 3–kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation
  2430. Activation of endothelial nitric oxide synthase by cilostazol via a cAMP/protein kinase A-and Phosphatidylinositol 3–kinase/Akt-dependent mechanism
  2431. Regulation of class-switch recombination and plasma cell differentiation by Phosphatidylinositol 3–kinase signaling
  2432. Differential association of Phosphatidylinositol 3–kinase, SHIP-1, and PTEN with forming phagosomes
  2433. The Phosphatidylinositol 3–kinase inhibitor, PX-866, is a potent inhibitor of cancer cell motility and growth in three-dimensional cultures
  2434. Identification and characterization of NVP-BEZ235, a new orally available dual Phosphatidylinositol 3–kinase/mammalian target of rapamycin inhibitor with potent in …
  2435. Dual regulatory roles of Phosphatidylinositol 3–kinase in IFN signaling
  2436. High prevalence and mutual exclusivity of genetic alterations in the Phosphatidylinositol–3–kinase/akt pathway in thyroid tumors
  2437. Activation of Phosphatidylinositol 3–kinase signaling by a mutant thyroid hormone β receptor
  2438. Influenza A virus NS1 protein binds p85β and activates Phosphatidylinositol–3–kinase signaling
  2439. Phosphatidylinositol 3–kinase/akt and ras/raf-mitogen-activated protein kinase pathway mutations in anaplastic thyroid cancer
  2440. Chronic kidney disease causes defects in signaling through the insulin receptor substrate/Phosphatidylinositol 3–kinase/Akt pathway: implications for muscle atrophy
  2441. Hsp27 inhibits Bax activation and apoptosis via a Phosphatidylinositol 3–kinase-dependent mechanism
  2442. Effects of endurance exercise training on insulin signaling in human skeletal muscle: interactions at the level of Phosphatidylinositol 3–kinase, Akt, and AS160
  2443. PIK3CA cooperates with other Phosphatidylinositol 3′-kinase pathway mutations to effect oncogenic transformation
  2444. Inhibition of Phosphatidylinositol 3–kinase Increases Efficacy of Cisplatin in in Vivo Ovarian Cancer Models
  2445. Phosphatidylinositol 3′-kinase/AKT Signaling Is Activated in Medulloblastoma Cell Proliferation and Is Associated with Reduced Expression of PTEN
  2446. Dysregulation of the Phosphatidylinositol 3–kinase pathway in thyroid neoplasia
  2447. Inhibition of the Phosphatidylinositol‐3 kinase/Akt promotes G1 cell cycle arrest and apoptosis in Hodgkin lymphoma
  2448. Association of PTEN gene methylation with genetic alterations in the Phosphatidylinositol 3‐kinase/AKT signaling pathway in thyroid tumors
  2449. Integrative Genomic Analysis of Phosphatidylinositol 3′-kinase Family Identifies PIK3R3 as a Potential Therapeutic Target in Epithelial Ovarian Cancer
  2450. Influenza A virus NS1 protein activates the Phosphatidylinositol 3–kinase (PI3K)/Akt pathway by direct interaction with the p85 subunit of PI3K
  2451. Antigen receptor–mediated changes in glucose metabolism in B lymphocytes: role of Phosphatidylinositol 3–kinase signaling in the glycolytic control of growth
  2452. Phosphatidylinositol 3–kinase-dependent modulation of carnitine palmitoyltransferase 1A expression regulates lipid metabolism during hematopoietic cell …
  2453. Erythropoietin involves the Phosphatidylinositol 3‐kinase pathway, 14‐3‐3 protein and FOXO3a nuclear trafficking to preserve endothelial cell integrity
  2454. Phosphatidylinositol 3–kinase is a key mediator of central sensitization in painful inflammatory conditions
  2455. Notch1 signaling promotes primary melanoma progression by activating mitogen-activated protein kinase/Phosphatidylinositol 3–kinase-Akt pathways and up …
  2456. Activation of the Phosphatidylinositol 3–kinase Vps34 by a G protein α subunit at the endosome
  2457. Hypoxic regulation of vascular endothelial growth factor through the induction of Phosphatidylinositol 3–kinase/Rho/ROCK and c-Myc
  2458. Oxidative stress stimulates skeletal muscle glucose uptake through a Phosphatidylinositol 3–kinase-dependent pathway
  2459. Frequent PTEN genomic alterations and activated Phosphatidylinositol 3–kinase pathway in basal-like breast cancer cells
  2460. Isoginkgetin inhibits tumor cell invasion by regulating Phosphatidylinositol 3–kinase/Akt–dependent matrix metalloproteinase-9 expression
  2461. Induction of Phosphatidylinositol 3‐kinase‐mediated endocytosis by salt stress leads to intracellular production of reactive oxygen species and salt tolerance
  2462. CCL2 protects prostate cancer PC3 cells from autophagic death via Phosphatidylinositol 3–kinase/AKT-dependent survivin up-regulation
  2463. Arachidonic acid activates Phosphatidylinositol 3–kinase signaling and induces gene expression in prostate cancer
  2464. Phosphatidylinositol 3–kinase and glycogen synthase kinase 3 regulate estrogen receptor-mediated transcription in neuronal cells
  2465. Inhibition of Phosphatidylinositol 3–kinase delays tumor progression and blocks metastatic spread in a mouse model of thyroid cancer
  2466. Energy depletion inhibits Phosphatidylinositol 3–kinase/Akt signaling and induces apoptosis via AMP-activated protein kinase-dependent phosphorylation of …
  2467. Highly prevalent genetic alterations in receptor tyrosine kinases and Phosphatidylinositol 3–kinase/akt and mitogen-activated protein kinase pathways in anaplastic …
  2468. Inhibition of Phosphatidylinositol 3–kinase destabilizes Mycn protein and blocks malignant progression in neuroblastoma
  2469. Myostatin induces cyclin D1 degradation to cause cell cycle arrest through a Phosphatidylinositol 3–kinase/AKT/GSK-3β pathway and is antagonized by …
  2470. ATP stimulates mouse embryonic stem