REVERSES AND PREVENTS HYPERLIPIDEMIA, HYPERCHOLESTEROLEMIA, DYSLIPIDEMIA AND HYPERTRIGLYCERIDEMIA
December 21, 2023CROSSLINK BREAKER
December 21, 2023- Anti-steatotic and anti-inflammatory effects of Hovenia dulcis Thunb. extracts in chronic alcohol-fed rats
- Gynura procumbens reverses Acute and Chronic Ethanol-induced Liver steatosis through MAPK/SREBP-1c-Dependent and -Independent Pathways
- Understanding the effect of anthocyanin extracted from Lonicera caerulea L. on alcoholic hepatosteatosis
- alcohol abstinence rescues hepatic steatosis and liver injury via improving metabolic reprogramming in chronic alcohol-fed mice
- Pharmacological activation of aldehyde dehydrogenase 2 by Alda-1 reverses alcohol–induced hepatic steatosis and cell death in mice
- alcohol–induced hepatic steatosis: A comparative study to identify possible indicator (s) of alcoholic fatty liver disease
- HIMH0021 attenuates ethanol-induced liver injury and steatosis in mice
- Oral intake of chicoric acid reduces acute alcohol–induced hepatic steatosis in mice
- Korean Red Ginseng attenuates ethanol-induced steatosis and oxidative stress via AMPK/Sirt1 activation
- Asperosaponin VI protects alcohol–induced hepatic steatosis and injury via regulating lipid metabolism and ER stress
- Echinacoside ameliorates alcohol–induced oxidative stress and hepatic steatosis by affecting SREBP1c/FASN pathway via PPARα
- Methyl ferulic acid attenuates ethanol-induced hepatic steatosis by regulating AMPK and FoxO1 pathways in rats and L-02 cells
- Quercetin alleviates ethanol-induced liver steatosis associated with improvement of lipophagy
- Scopoletin prevents alcohol–induced hepatic lipid accumulation by modulating the AMPK–SREBP pathway in diet-induced obese mice
- Oroxylin A prevents alcohol–induced hepatic steatosis through inhibition of hypoxia inducible factor 1alpha
- Root bark of Ulmus davidiana var. japonica restrains acute alcohol–induced hepatic steatosis onset in mice by inhibiting ROS accumulation
- Humulus japonicus Extract Ameliorates hepatic steatosis Through the PPARα-Mediated Suppression of alcohol–induced Oxidative Stress
- Effect of soyasaponins-rich extract from soybean on acute alcohol–induced hepatotoxicity in mice
- Lactobacillus plantarum ZY08 relieves chronic alcohol–induced hepatic steatosis and liver injury in mice via restoring intestinal flora homeostasis
- Baicalin ameliorates alcohol–induced hepatic steatosis by suppressing SREBP1c elicited PNPLA3 competitive binding to ATGL
- hepatic peroxisome proliferator‐activated receptor gamma signaling contributes to alcohol‐induced hepatic steatosis and inflammation in mice
- Betaine in ameliorating alcohol–induced hepatic steatosis
- Reversal of ethanol-induced hepatic steatosis and lipid peroxidation by taurine: a study in rats
- Depdc5 deficiency exacerbates alcohol–induced hepatic steatosis via suppression of PPARα pathway
- Fibroblast growth factor 21 deficiency exacerbates chronic alcohol–induced hepatic steatosis and injury
- Ligustrazine prevents alcohol–induced liver injury by attenuating hepatic steatosis and oxidative stress
- Mesencephalic astrocyte-derived neurotrophic factor alleviates alcohol induced hepatic steatosis via activating Stat3-mediated autophagy
- Monounsaturated fatty acid-enriched olive oil exacerbates chronic alcohol–induced hepatic steatosis and liver injury in C57BL/6J mice
- NAMPT overexpression alleviates alcohol–induced hepatic steatosis in mice
- Caffeic acid dimethyl ether alleviates alcohol–induced hepatic steatosis via microRNA-378b-mediated CaMKK2-AMPK pathway
- Aldehyde dedydrogenase-2 plays a beneficial role in ameliorating chronic alcohol–induced hepatic steatosis and inflammation through regulation of autophagy
- Sympathetic overdrive and unrestrained adipose lipolysis drive alcohol–induced hepatic steatosis in rodents
- Inhibition of Ghrelin Activity by Receptor Antagonist [d-Lys-3] GHRP-6 Attenuates alcohol–induced hepatic steatosis by Regulating hepatic Lipid Metabolism
- miR-203 inhibits alcohol–induced hepatic steatosis by targeting lipin1
- A plasma untargeted metabolomic study of Chinese medicine Zhi-Zi-Da-Huang decoction intervention to alcohol–induced hepatic steatosis
- Disturbances in the murine hepatic circadian clock in alcohol–induced hepatic steatosis
- Gomisin N alleviates ethanol-induced liver injury through ameliorating lipid metabolism and oxidative stress
- Ethanol-induced hepatic steatosis is modulated by glycogen level in the liver [S]
- Enhanced AMPK phosphorylation contributes to the beneficial effects of Lactobacillus rhamnosus GG supernatant on chronic-alcohol–induced fatty liver disease
- Magnesium isoglycyrrhizinate attenuates acute alcohol–induced hepatic steatosis in a zebrafish model by regulating lipid metabolism and ER stress
- Predominant role of sterol response element binding proteins (SREBP) lipogenic pathways in hepatic steatosis in the murine intragastric ethanol feeding model
- Suppression of acute ethanol-induced hepatic steatosis by docosahexaenoic acid is associated with downregulation of stearoyl-CoA desaturase 1 and inflammatory …
- Effect of iron on cholesterol 7α-hydroxylase expression in alcohol–induced hepatic steatosis in mice
- Hepatoprotective effects of sea cucumber ether-phospholipids against alcohol–induced lipid metabolic dysregulation and oxidative stress in mice
- Activation of autophagy attenuates EtOH-LPS-induced hepatic steatosis and injury through MD2 associated TLR4 signaling
- Increased hepatic receptor interacting protein kinase 3 expression due to impaired proteasomal functions contributes to alcohol–induced steatosis and liver …
- Binge Ethanol‐induced HDAC3 Down‐Regulates Cpt1α Expression Leading to hepatic steatosis and Injury
- miR-378b regulates insulin sensitivity by targeting insulin receptor and p110α in alcohol–induced hepatic steatosis
- Carbohydrate‐responsive element‐binding protein, Sirtuin 1, and ethanol metabolism: A complicated network in alcohol‐induced hepatic steatosis
- Quercetin mitigates ethanol-induced hepatic steatosis in zebrafish via P2X7R-mediated PI3K/Keap1/Nrf2 signaling pathway
- 1-Methylnicotinamide promotes hepatic steatosis in mice: A potential mechanism in chronic alcohol–induced fatty liver disease
- Herbal sgr formula prevents acute ethanol-induced liver steatosis via inhibition of lipogenesis and enhancement fatty acid oxidation in mice
- Involvement of AMP-activated protein kinase in beneficial effects of betaine on high-sucrose diet-induced hepatic steatosis
- Dietary tomato powder inhibits alcohol–induced hepatic injury by suppressing cytochrome p450 2E1 induction in rodent models
- Dysregulation of hepatic cAMP levels via altered Pde4b expression plays a critical role in alcohol‐induced steatosis
- Deficiency of NLR family member NLRC5 alleviates alcohol induced hepatic injury and steatosis by enhancing autophagy of hepatocytes
- AICAR, an AMPK activator, has protective effects on alcohol‐induced fatty liver in rats
- Dietary α-linolenic acid-rich flaxseed oil prevents against alcoholic hepatic steatosis via ameliorating lipid homeostasis at adipose tissue-liver axis in mice
- Puerariae Lobatae radix flavonoids and puerarin alleviate alcoholic liver injury in zebrafish by regulating alcohol and lipid metabolism
- A combination of Pueraria lobata and Silybum marianum protects against alcoholic liver disease in mice
- Inhibition of spleen tyrosine kinase activation ameliorates inflammation, cell death, and steatosis in alcoholic liver disease
- Mitochondria-targeted ubiquinone (MitoQ) enhances acetaldehyde clearance by reversing alcohol–induced posttranslational modification of aldehyde …
- The function of MGAT1 in alcohol–induced hepatic steatosis and treatment of hepatic steatosis via MGAT1 enzyme inhibition
- CYP2E1 potentiates binge alcohol–induced gut leakiness, steatohepatitis, and apoptosis
- Nrf2 activation is required for ligustrazine to inhibit hepatic steatosis in alcohol-preferring mice and hepatocytes
- The Adiponectin‐SIRT 1‐AMPK Pathway in alcoholic Fatty Liver Disease in the Rat
- Lactobacillus fermentum KP-3-fermented ginseng ameliorates alcohol–induced liver disease in C57BL/6N mice through the AMPK and MAPK pathways
- Imipramine blocks ethanol-induced ASMase activation, ceramide generation, and PP2A activation, and ameliorates hepatic steatosis in ethanol-fed mice
- Antilipogenic and Anti-Inflammatory Activities of Codonopsis lanceolata in Mice hepatic Tissues after Chronic Ethanol Feeding
- Binge alcohol–induced microvesicular liver steatosis and injury are associated with down‐regulation of hepatic Hdac 1, 7, 9, 10, 11 and up‐regulation of Hdac 3
- Upregulation of 4-hydroxynonenal contributes to the negative effect of n-6 polyunsaturated fatty acid on alcohol–induced liver injury and hepatic steatosis
- Immunological Features of alcohol–induced hepatic steatosis
- Tangeretin Protects Mice from alcohol–induced Fatty Liver by Activating Mitophagy through the AMPK–ULK1 Pathway
- The Edible Insect Gryllus bimaculatus Protects against Gut-Derived Inflammatory Responses and Liver Damage in Mice after Acute alcohol Exposure
- Water extract of green tea attenuates alcohol-related hepatitis by inhibiting liver inflammation and gut microbiota disturbance in mice
- Aldo-Keto Reductase Family 1 Member A1 (AKR1A1) Deficiency Exacerbates alcohol–induced hepatic Oxidative Stress, Inflammation, steatosis, and Fibrosis
- Lactobacillus rhamnosus GG treatment potentiates intestinal hypoxia-inducible factor, promotes intestinal integrity and ameliorates alcohol–induced liver injury
- Pathogenic role of phosphodiesterase 4 (pde4) in the development of alcohol induced hepatic steatosis.
- CTRP3 attenuates diet-induced hepatic steatosis by regulating triglyceride metabolism
- Methyl ferulic acid ameliorates alcohol–induced hepatic insulin resistance via miR-378b-mediated activation of PI3K-AKT pathway
- Pharmacological inhibition of NOX4 ameliorates alcohol–induced liver injury in mice through improving oxidative stress and mitochondrial function
- Diallyl trisulfide attenuates ethanol-induced hepatic steatosis by inhibiting oxidative stress and apoptosis
- HIF-1α induction suppresses excessive lipid accumulation in alcoholic fatty liver in mice
- Suppression of PPARγ-mediated monoacylglycerol O-acyltransferase 1 expression ameliorates alcoholic hepatic steatosis
- Gut‐restricted apical sodium‐dependent bile acid transporter inhibitor attenuates alcohol‐induced liver steatosis and injury in mice
- Low-carbohydrate high-fat dietary pattern ameliorates alcohol-related liver disease via a 6PGD-involved mechanism in mice
- Naringin attenuates alcoholic liver injury by reducing lipid accumulation and oxidative stress
- Stress‐responsive gene FK506‐Binding protein 51 mediates alcohol‐induced liver injury through the Hippo pathway and chemokine (C‐X‐C Motif) ligand 1 signaling
- alcohol–induced CYP2E1, mitochondrial dynamics and retrograde signaling in human hepatic 3D organoids
- Melatonin upregulates the activity of AMPK and attenuates lipid accumulation in alcohol–induced rats
- Transient receptor potential vanilloid 1 gene deficiency ameliorates hepatic injury in a mouse model of chronic binge alcohol–induced alcoholic liver disease
- Dihydroartemisinin protects against alcoholic liver injury through alleviating hepatocyte steatosis in a farnesoid X receptor-dependent manner
- Transgenic overexpression of CTRP3 prevents alcohol–induced hepatic triglyceride accumulation
- Lactobacillus rhamnosus GG reduces hepatic TNFα production and inflammation in chronic alcohol–induced liver injury
- Ginsenoside Rb1 alleviates alcohol–induced liver injury by inhibiting steatosis, oxidative stress, and inflammation
- Hepatoprotective potential of Aloe vera polysaccharides against chronic alcohol‐induced hepatotoxicity in mice
- Blueberry polyphenols play a preventive effect on alcoholic fatty liver disease C57BL/6 J mice by promoting autophagy to accelerate lipolysis to eliminate …
- Therapeutic benefits of spleen tyrosine kinase inhibitor administration on binge drinking‐induced alcoholic liver injury, steatosis, and inflammation in mice
- Dietary fisetin supplementation protects against alcohol‐induced liver injury in mice
- Genistein Protects against Acetaldehyde-induced Oxidative Stress and Hepatocyte Injury in Chronic alcohol-Fed Mice
- Aldehyde Dehydrogenase-2 (ALDH2) Ameliorates Chronic alcohol Ingestion-induced hepatic steatosis and Inflammation: Role of Autophagy
- Activation of PPARα-catalase pathway reverses alcoholic liver injury via upregulating NAD synthesis and accelerating alcohol clearance
- Molecular mechanism of alcoholic fatty liver
- Naringenin inhibits alcoholic injury by improving lipid metabolism and reducing apoptosis in zebrafish larvae
- Shanxi aged vinegar protects against alcohol–induced liver injury via activating Nrf2-mediated antioxidant and inhibiting TLR4-induced inflammatory response
- Dihydromyricetin modulates p62 and autophagy crosstalk with the Keap-1/Nrf2 pathway to alleviate ethanol-induced hepatic injury
- ZFP36L1 regulates Fgf21 mRNA turnover and modulates alcoholic hepatic steatosis and inflammation in mice
- In vivo hepatoprotective effects of a peptide fraction from krill protein hydrolysates against alcohol–induced oxidative damage
- TLR9 signaling protects alcohol–induced hepatic oxidative stress but worsens liver inflammation in mice
- Salvianolic acid B protects against chronic alcoholic liver injury via SIRT1-mediated inhibition of CRP and ChREBP in rats
- microRNA-378b regulates ethanol-induced hepatic steatosis by targeting CaMKK2 to mediate lipid metabolism
- Protective effects of oyster extract against hepatic tissue injury in alcoholic liver diseases
- The role of lipid metabolism in the pathogenesis of alcoholic and nonalcoholic hepatic steatosis
- The inhibitory effect of ethanol on Sestrin3 in the pathogenesis of ethanol-induced liver injury
- The study of Yin-Chen-Hao-Tang preventing and treating alcoholic fatty liver disease through PPAR signaling pathway based on network pharmacology and …
- Metagenomic Analyses of alcohol induced Pathogenic Alterations in the Intestinal Microbiome and the Effect of Lactobacillus rhamnosus GG Treatment
- Berberine Ameliorates Abnormal Lipid Metabolism via the Adenosine Monophosphate–Activated Protein Kinase/Sirtuin 1 Pathway in alcohol-Related Liver Disease
- Chronic alcohol exposure alters circulating insulin and ghrelin levels: role of ghrelin in hepatic steatosis
- Obeticholic acid ameliorates valproic acid–induced hepatic steatosis and oxidative stress
- Activation of AhR-NQO1 signaling pathway protects against alcohol–induced liver injury by improving redox balance
- Roxadustat, a hypoxia-inducible factor 1α activator, attenuates both long-and short-term alcohol–induced alcoholic liver disease
- Loss of ERdj5 exacerbates oxidative stress in mice with alcoholic liver disease via suppressing Nrf2
- Ghrelin regulates adipose tissue metabolism: Role in hepatic steatosis
- Dihydroartemisinin attenuates alcoholic fatty liver through regulation of lipin‐1 signaling
- Reduced Susceptibility of DNA Methyltransferase 1 Hypomorphic (Dnmt1N/+) Mice to hepatic steatosis upon Feeding Liquid alcohol Diet
- Synergistic Protective Effect of Fermented Schizandrae Fructus Pomace and Hoveniae Semen cum Fructus Extracts Mixture in the Ethanol-induced Hepatotoxicity
- Liver kinase B1/AMP‐activated protein kinase‐mediated regulation by gentiopicroside ameliorates P2X7 receptor‐dependent alcoholic hepatosteatosis
- D-Mannose Regulates Hepatocyte Lipid Metabolism via PI3K/Akt/mTOR Signaling Pathway and Ameliorates hepatic steatosis in alcoholic Liver Disease
- RAGE promotes dysregulation of iron and lipid metabolism in alcoholic liver disease
- Silkworm (Bombyx mori) powder supplementation alleviates alcoholic fatty liver disease in rats
- Adipose-specific lipin1 overexpression in mice protects against alcohol–induced liver injury
- Loss of long-chain acyl-CoA synthetase 1 promotes hepatocyte death in alcohol–induced steatohepatitis
- Dietary agents in the prevention of alcohol–induced hepatotoxicty: preclinical observations
- Acrolein is a pathogenic mediator of alcoholic liver disease and the scavenger hydralazine is protective in mice
- alcoholic-induced hepatic steatosis—role of ceramide and protein phosphatase 2A
- Betaine attenuates alcohol–induced pancreatic steatosis
- hepatic NCoR1 deletion exacerbates alcohol–induced liver injury in mice by promoting CCL2-mediated monocyte-derived macrophage infiltration
- Polydatin alleviated alcoholic liver injury in zebrafish larvae through ameliorating lipid metabolism and oxidative stress
- hepatic overproduction of 13-HODE due to ALOX15 upregulation contributes to alcohol–induced liver injury in mice
- Intestinal HIF-1α deletion exacerbates alcoholic liver disease by inducing intestinal dysbiosis and barrier dysfunction
- Immunometabolic Cross-Talk and Regulation of Endocrine and Metabolic Functions: Transgenic overexpression of CTRP3 prevents alcohol–induced hepatic …
- Glucagon-like peptide 1 receptor agonist, exendin-4, reduces alcohol-associated fatty liver disease
- Dietary camellia seed oil attenuates liver injury in mice chronically exposed to alcohol
- A Corn Oil–Based Diet Protects Against Combined Ethanol and Iron‐induced Liver Injury in a Mouse Model of Hemochromatosis
- Inhibition of cereblon by fenofibrate ameliorates alcoholic liver disease by enhancing AMPK
- IL-17 signaling in steatotic hepatocytes and macrophages promotes hepatocellular carcinoma in alcohol-related liver disease
- The epigenetic regulator SIRT6 protects the liver from alcohol–induced tissue injury by reducing oxidative stress in mice
- Therapeutic potential of Chinese herbal medicines in alcoholic liver disease
- p53 protects against alcoholic fatty liver disease via ALDH2 inhibition
- Activation of carbohydrate response element-binding protein by ethanol
- Inhibition of hepatotoxicity by a LXR inverse agonist in a model of alcoholic liver disease
- Neuronal modulation of hepatic lipid accumulation induced by bingelike drinking
- The effect of taurine depletion by β-alanine treatment on the susceptibility to ethanol-induced hepatic dysfunction in rats
- Adiponectin deficiency rescues high-fat diet-induced hepatic injury, apoptosis and autophagy loss despite persistent steatosis
- Oyster protein hydrolysates alleviated chronic alcohol–induced liver injury in mice by regulating hepatic lipid metabolism and inflammation response
- Dietary linoleic acid and its oxidized metabolites exacerbate liver injury caused by ethanol via induction of hepatic proinflammatory response in mice
- Nrf2 knockdown disrupts the protective effect of curcumin on alcohol–induced hepatocyte necroptosis
- S100a16 Deficiency Prevents alcohol–induced Fatty Liver Injury via Inducing MANF Expression in Mice
- Trehalose activates hepatic transcription factor EB (TFEB) but fails to ameliorate alcohol‐impaired TFEB and liver injury in mice
- Walnut (Juglans regia L.) Oligopeptides Alleviate alcohol–induced Acute Liver Injury through the Inhibition of Inflammation and Oxidative Stress in Rats
- Anti‐inflammatory and anti‐apoptotic roles of endothelial cell STAT3 in alcoholic liver injury
- Suppression of endoplasmic reticulum stress-associated pathways and hepatocyte apoptosis participates in the attenuation of betulinic acid on alcohol-provoked liver …
- Deletion of Gab2 in mice protects against hepatic steatosis and steatohepatitis: a novel therapeutic target for fatty liver disease
- β-Lapachone alleviates alcoholic fatty liver disease in rats
- Cranberry (Vaccinium macrocarpon) peel polyphenol-rich extract attenuates rat liver mitochondria impairments in alcoholic steatohepatitis in vivo and after oxidative …
- Involvement and mechanism of DGAT2 upregulation in the pathogenesis of alcoholic fatty liver disease
- Metformin protects against ethanol-induced liver triglyceride accumulation by the LKB1/AMPK/ACC pathway
- Ginsenoside rc modulates SIRT6-NRF2 interaction to alleviate alcoholic liver disease
- Lipophagy and alcohol–induced fatty liver
- Purinergic P2X7 receptor blockade mitigates alcohol–induced steatohepatitis and intestinal injury by regulating MEK1/2-ERK1/2 signaling and egr-1 activity
- Hepatoprotective effects of curcumin in alcohol–induced hepatotoxicity: a memoir on the preclinical studies
- DNA-PKcs promotes alcohol-related liver disease by activating Drp1-related mitochondrial fission and repressing FUNDC1-required mitophagy
- Delayed ethanol elimination and enhanced susceptibility to ethanol-induced hepatosteatosis after liver resection
- Ganoderic acids-rich ethanol extract from Ganoderma lucidum protects against alcoholic liver injury and modulates intestinal microbiota in mice with …
- Essential role of IFN-γ in regulating gut antimicrobial peptides and microbiota to protect against alcohol–induced bacterial translocation and hepatic …
- Ceramide synthase 6 (CerS6) is upregulated in alcohol-associated liver disease and exhibits sex-based differences in the regulation of energy homeostasis and lipid …
- Transgenic overexpression of CTRP3 prevents alcohol–induced hepatic triglyceride accumulation 2 Greta Trogen1, Joshua Bacon1, Ying Li2, Gary L. Wright2, Ashley …
- Persistent mTORC1 activation via Depdc5 deletion results in spontaneous hepatocellular carcinoma but does not exacerbate carcinogen-and high-fat diet-induced …
- Mechanisms and intervention strategies for alcohol and HIV-antiretroviral therapy-induced liver injury.
- Hepatocyte-derived MANF mitigates ethanol-induced liver steatosis in mice via enhancing ASS1 activity and activating AMPK pathway
- Heme oxygenase-1 alleviates alcoholic liver steatosis: histopathological study
- PCSK9 inhibition as a novel therapeutic target for alcoholic liver disease
- The role of MLKL in hepatic Ischemia-Reperfusion Injury of alcoholic Steatotic Livers
- Lactobacillus rhamnosus GG culture supernatant ameliorates acute alcohol–induced intestinal permeability and liver injury
- New insights in the pathogenesis of alcohol-related liver disease: the metabolic, immunologic, and neurologic pathways☆
- Echinacea purpurea polysaccharide prepared by fractional precipitation prevents alcoholic liver injury in mice by protecting the intestinal barrier and regulating liver …
- Inhibition of aldose reductase ameliorates alcoholic liver disease by activating AMPK and modulating oxidative stress and inflammatory cytokines
- Intestinal ELF4 deletion exacerbates alcoholic liver disease by disrupting gut homeostasis
- SREBP1c mediates the effect of acetaldehyde on Cidea expression in alcoholic fatty liver Mice
- Red mulberry fruit aqueous extract and silk proteins accelerate acute ethanol metabolism and promote the anti‑oxidant enzyme systems in rats
- Anthocyanin-Rich Extract of Red Cabbage Attenuates Advanced alcohol Hepatotoxicity in Rats in Association with Mitochondrial Activity Modulation
- Chronic ethanol consumption-induced hepatotoxicity and protective effect of Boswellia serrata
- Artemisia Iwayomogi Extract Attenuates High-Fat Diet-induced Hypertriglyceridemia in Mice: Potential Involvement of the Adiponectin-AMPK Pathway and Very Low …
- Role of mechanistic target of rapamycin and autophagy in alcohol–induced adipose atrophy and liver injury
- Costunolide protects against alcohol‐induced liver injury by regulating gut microbiota, oxidative stress and attenuating inflammation in vivo and in vitro
- The role of ceramide in the pathogenesis of alcoholic liver disease
- DRAM1 increases the secretion of PKM2-enriched EVs from hepatocytes to promote macrophage activation and disease progression in ALD
- Inhibition of heat shock protein 90 alleviates steatosis and macrophage activation in murine alcoholic liver injury
- Intestinal epithelial β klotho is a critical protective factor in alcohol–induced intestinal barrier dysfunction and liver injury
- Natural products, extracts and formulations comprehensive therapy for the improvement of motor function in alcoholic liver disease
- Iron oxide nanoparticles aggravate hepatic steatosis and liver injury in nonalcoholic fatty liver disease through BMP-SMAD-mediated hepatic iron overload
- Cannabinoid CB2 receptors protect against alcoholic liver disease by regulating Kupffer cell polarization in mice
- Pharmacological chaperone therapies: Can aldehyde dehydrogenase activator make us healthier?
- alcoholic, nonalcoholic, and toxicant-associated steatohepatitis: mechanistic similarities and differences
- Defect of mitochondrial respiratory chain is a mechanism of ROS overproduction in a rat model of alcoholic liver disease: role of zinc deficiency
- Fibroblast growth factor 21 is required for the therapeutic effects of Lactobacillus rhamnosus GG against fructose-induced fatty liver in mice
- Enhanced Ca2+-channeling complex formation at the ER-mitochondria interface underlies the pathogenesis of alcohol-associated liver disease
- Dihydroartemisinin protects against alcoholic liver injury through alleviating
- Bifidobacterium breve ATCC15700 pretreatment prevents alcoholic liver disease through modulating gut microbiota in mice exposed to chronic alcohol intake
- Effect of ethanol on lipid metabolism
- Ablation of Akt2 and AMPKα2 rescues high fat diet-induced obesity and hepatic steatosis through Parkin-mediated mitophagy
- Cholesterol Regulation by Leptin in alcoholic Liver Disease
- Hepatoprotective potential of partially hydrolyzed guar gum against acute alcohol–induced liver injury in vitro and vivo
- The critical role of redox regulation of PTEN and peroxiredoxin III in alcoholic fatty liver
- Ginseng (Panax ginseng Meyer) Oligopeptides Protect Against Binge Drinking-induced Liver Damage through Inhibiting Oxidative Stress and Inflammation in Rats
- Lactobacillus plantarum LC27 and Bifidobacterium longum LC67 mitigate alcoholic steatosis in mice by inhibiting LPS-mediated NF-κB activation through restoration …
- Oxidation of fish oil exacerbates alcoholic liver disease by enhancing intestinal dysbiosis in mice
- Perilipin 5 protects the mitochondrial oxidative functions and improves the alcoholic liver injury in mice
- Metformin Ameliorates Ethanol-induced Liver Triglyceride Accumulation by LKB1/AMPK/ACC Pathway
- Dietary β-conglycinin prevents acute ethanol-induced fatty liver in mice
- alcoholic liver disease-from steatosis to cirrhosis-a biochemistry approach
- Chronic alcohol consumption has a biphasic effect on hepatic retinoid loss
- Metabolomics Study of Serum from a Chronic alcohol-Fed Rat Model Following Administration of Defatted Tenebrio molitor Larva Fermentation Extract
- Loss of SQSTM1/p62 Induces Obesity and Exacerbates alcohol–induced Liver Injury in Aged Mice
- Hesperidin protects against acute alcoholic injury through improving lipid metabolism and cell damage in zebrafish larvae
- Liver-specific Nrf2 deficiency accelerates ethanol-induced lethality and hepatic injury in vivo
- Transcriptomic Analysis Reveals Lactobacillus reuteri Alleviating alcohol–induced Liver Injury in Mice by Enhancing the Farnesoid X Receptor Signaling Pathway
- CTRP3 and alcoholic Liver Disease in Female Mice
- Activation of peroxisome proliferator-activated receptor-γ by rosiglitazone improves lipid homeostasis at the adipose tissue-liver axis in ethanol-fed mice
- Regulation of NOX/p38 MAPK/PPARα pathways and miR-155 expression by boswellic acids reduces hepatic injury in experimentally-induced alcoholic liver disease …
- Role of phosphodiesterase-4 in alcohol–induced organ injury.
- Protection of LP-cs on acute alcohol–induced liver and intestine injury
- Chronic alcohol Consumption Causes Liver Injury in High‐Fructose‐Fed Male Mice Through Enhanced hepatic Inflammatory Response
- Glutamate signaling in hepatic stellate cells drives alcoholic steatosis
- Inhibition of HMGB1/TLR4 signaling pathway by digitoflavone: a potential therapeutic role in alcohol-associated liver disease
- Dietary Bacillus subtilis supplementation alleviates alcohol‑induced liver injury by maintaining intestinal integrity and gut microbiota homeostasis in mice
- Ginsenoside Rg1 inhibits inflammatory responses via modulation of the nuclear factor‑κB pathway and inhibition of inflammasome activation in alcoholic hepatitis
- Gender differences in early alcohol–induced liver injury: role of CD14, NF-κB, and TNF-α
- Fuzhuan brick tea ameliorates hepatic steatosis and steatohepatitis through gut microbiota-derived aryl hydrocarbon receptor ligands in high-fat diet-induced obese …
- Promotion of autophagosome–lysosome fusion via salvianolic acid A-mediated SIRT1 up-regulation ameliorates alcoholic liver disease
- Probiotics counteract hepatic steatosis caused by ketogenic diet and upregulate AMPK signaling in a model of infantile epilepsy
- Combination of s-methyl cysteine and protocatechuic acid provided greater lipid-lowering and anti-inflammatory effects in mice liver against chronic alcohol …
- Oroxylin a promotes PGC-1α/Mfn2 signaling to attenuate hepatocyte pyroptosis via blocking mitochondrial ROS in alcoholic liver disease
- Protective Effect of Probiotic in alcohol–induced Liver Disorders: Role of Probiotics in alcohol–induced Liver Disorders
- Nanoformulated SOD1 ameliorates the combined NASH and alcohol-associated liver disease partly via regulating CYP2E1 expression in adipose tissue and liver
- alcohol–induced Hsp90 acetylation is a novel driver of liver sinusoidal endothelial dysfunction and alcohol-related liver disease
- Diallyl trisulfide protects against ethanol-induced oxidative stress and apoptosis via a hydrogen sulfide-mediated mechanism
- Absolute quantitative lipidomics reveals lipids profiling in liver of mice with early-stage alcoholic liver disease
- Genetically encoded probiotic EcN 1917 alleviates alcohol–induced acute liver injury and restore gut microbiota homeostasis
- Linking dysregulated AMPK signaling and ER stress in ethanol-induced liver injury in hepatic alcohol dehydrogenase deficient deer mice
- Contrasting effects of fasting on liver-adipose axis in alcohol-associated and non-alcoholic fatty liver
- MicroRNA-29b ameliorates hepatic inflammation via suppression of STAT3 in alcohol-associated liver disease
- Pretreatment with the ALDH2 activator Alda‑1 protects rat livers from ischemia/reperfusion injury by inducing autophagy
- alcoholic liver disease: A current molecular and clinical perspective
- Therapy of NAFLD: antioxidants and cytoprotective agents
- The role of SHP/REV-ERBα/CYP4A axis in the pathogenesis of alcohol-associated liver disease
- Adipose tissue autophagy and homeostasis in alcohol–induced liver injury
- Physcion alleviates chronic alcoholic hepatic inflammation and pyroptosis through SIRT1-AMPK activation
- Protective effects of cichoric acid on H2O2-induced oxidative injury in hepatocytes and larval zebrafish models
- Oroxylin A regulates the turnover of lipid droplet via downregulating adipose triglyceride lipase (ATGL) in hepatic stellate cells
- Site‐specific identification and validation of hepatic histone nitration in vivo: Implications for alcohol‐induced liver injury
- Comprehensive analysis of the expression profiles of hepatic lncRNAs in the mouse model of alcoholic liver disease
- Compound probiotic ameliorates acute alcoholic liver disease in mice by modulating gut microbiota and maintaining intestinal barrier
- Lipid droplet dynamics in alcoholic fatty liver disease
- Protective mechanism of edible food plants against alcoholic liver disease with special mention to polyphenolic compounds
- Anti-inflammatory and hepatoprotective effects of exopolysaccharides isolated from Pleurotus geesteranus on alcohol–induced liver injury
- Role of gut bacterial and non-bacterial microbiota in alcohol-associated liver disease: Molecular mechanisms, biomarkers, and therapeutic prospective
- Qinggan Huoxue Recipe Protects against Experimental alcoholic Liver Fibrosis through CXCL16 Inhibition
- Decreasing phosphatidylcholine on the surface of the lipid droplet correlates with altered protein binding and steatosis
- Is cannabidiol hepatotoxic or hepatoprotective: A review
- Indole-3-acetamide from gut microbiota activated hepatic AhR and mediated the remission effect of Lactiplantibacillus plantarum P101 on alcoholic liver injury in mice
- Protection of Inonotus hispidus (Bull.) P. Karst. against Chronic alcohol–induced Liver Injury in Mice via Its Relieving Inflammation Response
- Dissociation between diurnal cycles in locomotor activity, feeding behavior and hepatic PERIOD2 expression in chronic alcohol-fed mice
- Effect of taurine on alcoholic liver disease in rats
- Role of autophagy and regulatory mechanisms in alcoholic cardiomyopathy
- Protective effects of probiotics on acute alcohol–induced liver injury in mice through alcohol metabolizing enzymes activation and hepatic TNF-α response reduction
- An overview of the mechanism of Penthorum chinense Pursh on alcoholic fatty liver
- Glutamate/metabotropic glutamate receptor-5 signaling in hepatic stellate cells drives endocannabinoid-mediated alcoholic steatosis
- Distinct histopathological phenotypes of severe alcoholic hepatitis suggest different mechanisms driving liver injury and failure
- Plant-based foods and their bioactive compounds on fatty liver disease: Effects, mechanisms, and clinical application
- FGF21 induced by carbon monoxide mediates metabolic homeostasis via the PERK/ATF4 pathway
- P2X7 receptor‐targeted regulation by tetrahydroxystilbene glucoside in alcoholic hepatosteatosis: A new strategy towards macrophage–hepatocyte crosstalk
- alcohol–induced liver injury in signalling pathways and curcumin’s therapeutic potential
- Role of mitochondria in alcoholic liver disease
- Total saponins from Panax japonicus attenuate acute alcoholic liver oxidative stress and hepatosteatosis by p62-related Nrf2 pathway and AMPK-ACC/PPARα axis in …
- Hepatitis B virus X protein induces ALDH2 ubiquitin-dependent degradation to enhance alcoholic steatohepatitis
- alcohol induces more severe fatty liver disease by influencing cholesterol metabolism
- Acrolein Is a Pathogenic Mediator of alcoholic Liver Disease and the Scavenger Hydralazine Is Protective in Mice
- Liver iron loading in alcohol-associated liver disease
- Profiling of polar metabolites in mouse feces using four analytical platforms to study the effects of cathelicidin-related antimicrobial peptide in alcoholic liver disease
- Role of Adipose Lipolysis in Development of alcoholic Liver Disease
- hepatic regulator of G protein signaling 6 (RGS6) drives non-alcoholic fatty liver disease by promoting oxidative stress and ATM-dependent cell death
- alcohol and liver clock disruption increase small droplet macrosteatosis, alter lipid metabolism and clock gene mRNA rhythms, and remodel the triglyceride lipidome …
- Fibroblast growth factor 21 (FGF21) is robustly induced by ethanol and has a protective role in ethanol associated liver injury
- Dysregulation of hepatic zinc transporters in a mouse model of alcoholic liver disease
- Emerging roles of SIRT1 in fatty liver diseases
- Resveratrol alleviates alcoholic fatty liver in mice
- The murine hepatic sequelae of long-term ethanol consumption are sex-specific and exacerbated by Aldh1b1 loss
- Taxifolin ameliorate high-fat-diet feeding plus acute ethanol binge-induced steatohepatitis through inhibiting inflammatory caspase-1-dependent pyroptosis
- Protective effects of lactic acid bacteria against TLR4 induced inflammatory response in hepatoma HepG2 cells through modulation of toll-like receptor negative …
- Role of cAMP and phosphodiesterase signaling in liver health and disease
- Blocking alcoholic steatosis in mice with a peripherally restricted purine antagonist of the type 1 cannabinoid receptor
- The methyl donor S-adenosylmethionine prevents liver hypoxia and dysregulation of mitochondrial bioenergetic function in a rat model of alcohol–induced …
- Levilactobacillus brevis MG5311 Alleviates Ethanol-induced Liver Injury by Suppressing hepatic Oxidative Stress in C57BL/6 Mice
- Mechanism for prevention of alcohol–induced liver injury by dietary methyl donors
- Inhibition of vascular endothelial growth factor signaling facilitates liver repair from acute ethanol-induced injury in zebrafish
- Cheong-sang-bang-pung-san alleviated hepatic lipid accumulation by regulating lipid metabolism in vitro and in vivo
- Iron and iron-related proteins in alcohol consumers: cellular and clinical aspects
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- A novel fibroblast growth factor 1 variant reverses nonalcoholic fatty liver disease in type 2 diabetes.
- Natural compounds for counteracting nonalcoholic fatty liver disease (NAFLD): advantages and limitations of the suggested candidates
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- Mechanism and therapeutic opportunities of histone modifications in chronic liver disease
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- Host homeostatic responses to alcohol–induced cellular stress in animal models of alcoholic liver disease
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- alcohol inhibits T-cell glucose metabolism and hepatitis in ALDH2-deficient mice and humans: roles of acetaldehyde and glucocorticoids
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- Lpin1/2, Dgat2, and Pnpla2/3), and lipid droplet (Plin2/5, Lipe, Mgll, and Abdh5) genes, along with protein abundances of p-ACC, MCD, and FASN. Lipidomics …
- PPARγ-mediated insulin sensitization: the importance of fat versus muscle
- TMT-Based Quantitative Proteomics Reveals the Targets of Andrographolide on LPS-induced Liver Injury
- The role and possible mechanism of lncRNA U90926 in modulating 3T3-L1 preadipocyte differentiation
- MicroRNAs as systemic biomarkers to assess distress in animal models for gastrointestinal diseases
- Amaranth’s 2-caffeoylisocitric acid—An anti-inflammatory caffeic acid derivative that impairs NF-κB signaling in LPS-challenged RAW 264.7 macrophages
- TRP channels as sensors of aldehyde and oxidative stress
- Possible Mechanisms of the Prevention of Doxorubicin Toxicity by Cichoric Acid—Antioxidant Nutrient
- The effect of fibroblast growth factor 21 on a mouse model of bovine viral diarrhea
- Variation in the DEPDC5 locus is associated with progression to hepatocellular carcinoma in chronic hepatitis C virus carriers
- Targeting ALDH2 in atherosclerosis: molecular mechanisms and therapeutic opportunities
- Long noncoding RNA ACART knockdown decreases 3T3-L1 preadipocyte proliferation and differentiation
- GPR120 suppresses adipose tissue lipolysis and synergizes with GPR40 in antidiabetic efficacy
- UVB-induced microvesicle particle release and its effects on the cutaneous microenvironment
- Inhibition of mTOR signaling with rapamycin regresses established cardiac hypertrophy induced by pressure overload
- Probiotics increase intramuscular fat and improve the composition of fatty acids in Sunit sheep through the adenosine 5′-monophosphate-activated protein …
- n–3 PUFAs Reduce T-Helper 17 Cell Differentiation by Decreasing Responsiveness to Interleukin-6 in Isolated Mouse Splenic CD4+ T Cells
- Aldehyde dehydrogenase 2 (ALDH2) and aging: is there a sensible link?
- MiR-203 regulates estrogen receptor α and cartilage degradation in IL-1β-stimulated chondrocytes
- The use of chicoric acid from Echinacea purpurea as a feed additive in poultry nutrition
- Lactobacillus plantarum ZJUIDS04 alleviates DSS-induced colitis via modulating gut microbiota
- Untargeted metabolomics profiles delineate metabolic alterations in mouse plasma during lung carcinoma development using UPLC-QTOF/MS in MSE mode
- PGC-1α: a key regulator of energy metabolism
- miR-378 affects metabolic disturbances in the mdx model of Duchenne muscular dystrophy
- Structural elucidation of 3-nitrophenylhydrazine derivatives of tricarboxylic acid cycle acids and optimization of their fragmentation to boost sensitivity in liquid …
- Study on the anti-mitochondrial apoptosis mechanism of Erigeron breviscapus injection based on UPLC-Q-TOF-MS metabolomics and molecular docking in …
- Enhancement in the catalytic activity of human salivary aldehyde dehydrogenase by alliin from garlic: implications in aldehyde toxicity and oral health
- Role of fibroblast growth factor 21 in obesity-induced hypothalamic inflammation
- HIF-1α is a potential molecular target for herbal medicine to treat diseases
- Combination of starvation interval and food volume determines the phase of liver circadian rhythm in Per2::Luc knock-in mice under two meals per day feeding
- Macrophage migration inhibitory factor deficiency augments doxorubicin‐induced cardiomyopathy
- A preliminary study on the possibility of fermented pineapple peel residue partially replacing whole corn silage in feeding Chuanzhong black goats
- Exercise-induced extracellular vesicles delay the progression of prostate cancer
- Effects of n-3 polyunsaturated fatty acids on chemical-induced liver injury in mice
- Human Amniotic Mesenchymal Stem Cells Alleviate aGVHD after allo-HSCT by Regulating Interactions between Gut Microbiota and Intestinal Immunity
- Bile Acids as Biomarkers and Evolutionary Phenotypes
- Liver scaffolds obtained by decellularization: A transplant perspective in liver bioengineering
- Obtaining Cell Cultures of Medicinal Plants
- Psychobiotic potential of Lactiplantibacillus plantarum: Current perspective in neurodegeneration and geriatric therapies
- Stress decreases spermatozoa quality and induces molecular alterations in zebrafish progeny
- Stress decreases spermatozoa quality and induces molecular alterations in zebrafish progeny
- Enzyme immobilization strategies and bioprocessing applications
- Metabolomic Profiling of Lungs from Mice Reveals the Variability of Metabolites in Pneumocystis Infection and the Metabolic Abnormalities in BAFF-R-Deficient Mice
- Mutations of DEPDC5 cause autosomal dominant focal epilepsies
- Knockout of the epilepsy gene Depdc5 in mice causes severe embryonic dysmorphology with hyperactivity of mTORC1 signalling
- Mutations in DEPDC5 cause familial focal epilepsy with variable foci
- alcohol: the role in nutrition and health
- Long noncoding RNA metastasis-associated lung adenocarcinoma transcript 1 correlates with microRNA-125b/microRNA-146a/microRNA-203 and predicts 2-year …
- Improvement of inflammatory bowel disease by lactic acid bacteria-derived metabolites: a review
- BIGKnock: fine-mapping gene-based associations via knockoff analysis of biobank-scale data
- Fine-mapping gene-based associations via knockoff analysis of biobank-scale data with applications to UK Biobank
- Parallel metabolomic profiling of cerebrospinal fluid, plasma, and spinal cord to identify biomarkers for spinal cord injury
- Neuregulin-1β promotes glucose uptake via PI3K/Akt in neonatal rat cardiomyocytes
- High-resolution in situ hybridization to whole-mount zebrafish embryos
- frontiers MINI REVIEW in Immunology published: 30 March 2022 doi: 10.3389/fimmu. 2022.876515
- Growth factors-based therapeutic strategies and their underlying signaling mechanisms for peripheral nerve regeneration
- Pharmacological correction of long QT-linked mutations in KCNH2 (hERG) increases the trafficking of Kv11.1 channels stored in the transitional endoplasmic …
- Unknown Etiology of Liver Abscess
- Advances in biological functions and clinical studies of FGF21
- Activity pattern, budget and diurnal rhythmicity of the brown-throated three-toed sloth (Bradypus variegatus) in northeastern Brazil
- and Hanxiao Ge () Air Force Medical Center of AFMU, Beijing 100142, China gehanxiao@ foxmail. com
- Advances in the mechanism of action of silent information regulator 1 in alcoholic liver disease and related pharmaceutical studies
- Current status and perspectives of fibroblast growth factor 21 in nonalcoholic fatty liver disease
- Ascites, Renal Dysfunction, and Hepatorenal Syndrome
- Features of lipidomic profile of erythrocyte membranes and blood serum in patients with fatty liver disease
- Association of hypoxic microenvironment with the development and progression of liver diseases
- Sleep Duration and the Gut Microbiota in Infancy: an exploration of the determinants of sleep and the association between sleep and the gut microbiota at 3 months of …
- The insulin receptor: structure, function, and signaling
