Advanced glycation end products Key players in skin aging? Abstract Aging is the progressive accumulation of damage to an organism over time leading to disease and death. Aging research has been very intensive in the last years aiming at characterizing the pathophysiology of aging and finding possibilities to fight age-related diseases. Various theories of aging have been proposed. In the last years advanced glycation end products (AGEs) have received particular attention in this context. AGEs are formed in high amounts in diabetes but also in the physiological organism during aging. They have been etiologically implicated in numerous diabetes- and age-related diseases. Strategies inhibiting AGE accumulation and signaling seem to possess a therapeutic potential in these pathologies. However, still little is known on the precise role of AGEs during skin aging. In this review the existing literature on AGEs and skin aging will be reviewed. In addition, existing and potential anti-AGE strategies that may be beneficial on skin aging will be discussed. Keywords: : advanced glycation end products, skin aging, photoaging, RAGE, AGEs Introduction Aging is defined as the progressive accumulation of damage over time, leading to disturbed function on the cellular, tissue and organ level and eventually to disease and death. Aging is a complex, multifactorial process where genetic, endogenous and environmental factors play a role.1 Skin is the largest organ of the human body and also the boundary between an organism and environment. As such, skin is subjected not only to the internal aging process but also to various external stressors, leading to distinct structural changes and affecting not only its youthful appearance, but also its various physiological functions. Aged skin shows disturbed skin permeability, angiogenesis, lipid and sweat production, immune function and vitamin D synthesis, manifesting among others as impaired wound healing, atrophy, vulnerability to external stimuli and development of several benign and malignant diseases (reviewed in Zouboulis et al.).2 Endogenously aged skin refers to changes reflecting the internal aging process of the organism and is being observed mainly in ultraviolet (UV) light-protected skin areas, such as the inner side of the arms. Macroscopically it is recognized by fine wrinkles, loss of elasticity, reduced epidermal and dermal thickness, while microscopically epidermal atrophy, decreased mitotic rate of basal keratinocytes, decreased proliferative capacity and cellular senescence, atrophy of the dermal extracellular matrix and change of the physiological properties of the connective tissue are typical characteristics.2-4 Exogenously aged skin or photoaged skin is the skin where endogenous aging processes are being aggravated by external stressors, mainly UV irradiation,2,5 but also by tobacco,6 chemicals and pollution.2,4 Apart from many similarities with endogenously aged skin, extrinsic aged skin is also characterized by a thickened epidermis and a hyperplasia of elastic tissue (solar elastosis).2,4 Until today, more than 300 theories of aging have been proposed, among them the theory of cellular senescence, decreased proliferative capacity and telomere shortening, mitochondrial DNA single mutations, the free radical theory and others, none of which can fully explain all changes observed in aging.7-11 According to the inflammatory theory of aging, a common
A Diet Enriched In Polyphenols And Polyunsaturated Fatty Acids, Lmn Diet, Affects Aging And The Phenotype Of A Mouse Model Of … Anti- Aging Effect Of Green Tea Polyphenols On D-Galactose-Induced Subacute Aging In Mice Anti- Aging Effects Of The Flavonoids Of Oxytropis Glabra Dc. On Mice. AntiAging Interventions: An Insight Into Polyphenols And Brain Aging Antioxidative Effect Of Total Flavonoids From Oxytropis Falcata Bunge On Aging Mice Induced By D-Galactose Beneficial Effects Of Berry Fruit Polyphenols On Neuronal And Behavioral Aging Benefits From Dietary Polyphenols For Brain Aging And Alzheimer'S Disease Cardioprotection By Cocoa Polyphenols And Ω-3 Fatty Acids: A Disease-Prevention Perspective On Aging -Associated Cardiovascular Risk Changes In The Anthocyanins, Flavonoids And Hydroxycinnamic Acid Esters During Fermentation And Aging Of Merlot And Cabernet Sauvignon Characteristics Of Lymphocyte Nuclear Factor-Κb Signal Transduction Kinase Expression In Aging Process And Regulatory Effect Of Epimedium Flavonoids Chemical Compounds Released From Five Different Woods Used To Make Barrels For Aging Wines And Spirits: Volatile Compounds And Polyphenols Chronic Intake Of Red Wine Polyphenols By Young Rats Prevents Aging -Induced Endothelial Dysfunction And Decline In Physical Performance: Role Of Nadph Oxidase Comparative Analysis Of Experimental Data About The Effects Of Various Polyphenols On Lifespan And Aging . Comparison Survey Of Evoo Polyphenols And Exploration Of Healthy Aging -Promoting Properties Of Oleocanthal And Oleacein Counteraction Of Skin Inflammation And Aging Or Cancer By Polyphenols And Flavonoids From Polypodium Leucotomos And Xanthohumol Counteraction Of Skin Inflammation And Aging Or Cancer By Polyphenols And Flavonoids From Polypodium Leucotomos And Xanthohumol Cytoprotective Polyphenols Against Chronological Skin Aging And Cutaneous Photodamage Determination Of Red Wine Flavonoids By Hplc And Effect Of Aging Dietary Polyphenols Consumption And Its Relation With Cognitive And Mental Health In Aging : A Review Dietary Sources Of Polyphenols In The Mediterranean Healthy Eating, Aging And Lifestyle (Meal) Study Cohort Effect Of Epimedium Flavonoids In Retarding Aging Of C. Elegans Effect Of Flavonoids From Apple Pericarp On Antioxidant Functions In D-Galactose-Induced Aging Mice Effect Of Flavonoids From Sophora Flavescens In Aging Mice Induced By D-Galactos Effect Of Herba Scutellariae Barbatae Flavonoids In Delaying Aging Of Caenorhabditis Elegans And Human Umbilical Vein Endothelial Cells In Vitro Effect Of The Ionizing Radiation And Aging Time On Total Flavonoids Contents In Brazilian Sugarcane Spirit Composed With Green Propolis Effect Of Total Flavonoids From Chrysanthemun Morifolium On Learning And Memory In Aging Mice Effects Of Aging And Dietary Supplementation With Polyphenols From Pinus Taeda Hydrolyzed Lignin On Quality Parameters, Fatty Acid Profile And Oxidative Stability Of … Effects Of Lifelong Intake Of Lemon Polyphenols On Aging And Intestinal Microbiome In The Senescence-Accelerated Mouse Prone 1 (Samp1) Effects Of Modified Tea Polyphenols On Lipid Oxidation In Chinese Bacon During Fermentation And Aging Effects Of Plant Polyphenols On Ovarian Follicular Reserve In Aging Rats Effects Of Resveratrol And Other Polyphenols On Sirt1: Relevance To Brain Function During Aging Effects Of The Fomes Officinalis Flavonoids On Anti- Senile Action In The Aging Model Mice Evolution Of Polyphenols In Red Wines From Vitis Vinifera
A Candidate Chinese Medicine Preparation-Fructus Viticis Total Flavonoids Inhibits Stem-Like Characteristics Of Lung cancer Stem-Like Cells A Global Study Of Associations Between cancer Risks And Consumption Of Macronutrients And Flavonoids A Review Of Flavonoids Against cancer And Its Mechanism A Review Of Significant Molecular Mechanisms Of Flavonoids In Prevention Of Prostate cancer A Review Of The Epidemiological Evidence On Tea, Flavonoids, And Lung cancer A Synopsis On Flavonoids From The Roots Of Scutellaria Baicalensis With Some Insights On Baicalein And Its Anti-cancer Properties Absolute Configuration And Anti-cancer Effect Of Prenylated Flavonoids And Flavonostilbenes From Sophora Pachycarpa: Possible Involvement Of Wnt Signaling Pathway Absorption, Metabolism, And Disposition Of Flavonoids And Their Role In The Prevention Of Distinctive cancer Types Abstract A176: Total Oligomeric Flavonoids (Tof) Of The Herb Tubers Cyperus Rotundus Induce Growth Inhibition And Apoptosis In Some cancer Cell Lines, A Preliminary … Advance In Studies On Anti-cancer Activity And Mechanism Of Flavonoids Adverse Effects. The Activated Receptor Binds To A Xenobiotic-Responsive Element With The Consequent Activation Of The Transcription Flavonoids At Concentrations At … Alkaloids And Flavonoids From Ficus, Artocarpus And Macaranga Species: Structure And Anti-cancer Activity An Apple A Day To Prevent cancer Formation: Reducing cancer Risk With Flavonoids An Association Map On The Effect Of Flavonoids On The Signaling Pathways In Colorectal cancer Analysis Of Change In Microrna Expression Profiles Of Lung cancer A549 Cells Treated With Radix Tetrastigma Hemsleyani Flavonoids Anti-Breast cancer Mechanism Of Flavonoids Anticancer Activity And Mechanism Of Total Flavonoids Extracted From Scutellaria Barbata On Human Tongue cancer Cell Line Sas Anti-cancer Activity Of Flavonoids From Xinjiang Glycyrrhiza Inflata Licorice On Proliferation, Cytotoxicity And Apoptosis In Cervical carcinoma Cells Anti-cancer Activity Of Two Flavonoids In Leaf And Stem Of Tagetes Erecta Anti-cancer Potential Of Flavonoids: Recent Trends And Future Perspectives Antioxidant And Antiproliferative Effects Of Flavonoids From Emilia Sonchifolia Linn On Human cancer Cells Antiproliferation Effect And Apoptosis Mechanism Of Prostate cancer Cell Pc-3 By Flavonoids And Saponins Prepared From Gynostemma Pentaphyllum Antiproliferative Activities Of Citrus Flavonoids Against Six Human cancer Cell Lines Antiproliferative Activity Of Flavonoids On Several cancer Cell Lines Antiproliferative Activity Of Prenylated Flavonoids From Hops Against Versatile Human cancer Entities Antiproliferative And Cytotoxic Effects Of Prenylated Flavonoids From Hops (Humulus Lupulus) In Human cancer Cell Lines Antiproliferative Effect Of Flavonoids From The Halophyte Vitex Rotundifolia On Human cancer Cells Anti-Proliferative Effect Of Flos Albiziae Flavonoids On The Human Gastric cancer Sgc-7901 Cell Line Antiproliferative Mechanisms Of The Flavonoids 2, 2′-Dihydroxychalcone And Fisetin In Human Prostate cancer Cells Antiproliferative Potency Of Structurally Distinct Dietary Flavonoids On Human Colon cancer Cells Anti-Proliferative Properties Of Prenylated Flavonoids From Hops (Humulus Lupulus L.) In Human Prostate cancer Cell Lines Anti tumor Activity Of Some natural Flavonoids And Synthetic Derivatives On Various Human And Murine cancer Cell Lines Anti tumor Activity Of Total Flavonoids From Daphne Genkwa In Colorectal cancer Anti-Tumour Flavonoids Regulation On Oestrogen And Progesterone Receptor Genes In Cervical cancer Cell Lines (Hela) Apoptosis Induced By Flavonoids Extract Of Wheat Germ In A
“Ashwagandha”–This Ancient Indiant Plant Completely Rebuilds Your Brain & extend Lifespan 10-Hydroxy-2-Decenoic Acid, The Major Lipid Component Of Royal Jelly, extends The Lifespan Of Caenorhabditis Elegans Through Dietary Restriction And Target Of … 2-Secd Treatment extends Lifespan, Improves Healthspan And Enhances Resistance To Stress In Caenorhabditis Elegans 35. Systemic Administration Of Raav6-Microdystrophin Preserves Muscle Function And extends Lifespan In The Dystrophin-/Utrophin-Mouse Model Of Severe … 4E-Bp extends Lifespan Upon Dietary Restriction By Enhancing Mitochondrial Activity In Drosophila 629. Intravenous Delivery Of A Mtmr2-Encoding Aav9 Vector extends Lifespan And Improves Muscle Function In Mice With X-Linked Myotubular Myopathy 713. Intracsf Administration Of Aav9/Mecp2 extends Lifespan Of Mecp2-Null Mice While Preventing Toxicity Associated With Iv Administration A Better Strategy To extend The Proliferative Lifespan Of Human T-Cells In Vitro. A Carboxyfullerene Sod Mimetic Improves Cognition And extends The Lifespan Of Mice A C-Terminal Truncated Mutation Of Spr-3 Gene extends Lifespan In Caenorhabditis Elegans A Cytosolic Catalase Is Needed To extend Adult Lifespan In C. Elegans Daf-C And Clk-1 Mutants A Deuterohemin Peptide extends Lifespan And increases Stress Resistance In Caenorhabditis Elegans A Double Whammy For Aging? Rapamycin extends Lifespan And Inhibits Cancer In Inbred Female Mice A Fucose Containing Polymer-Rich Fraction From The Brown Alga Ascophyllum Nodosum Mediates Lifespan increase And Thermal-Tolerance In Caenorhabditis Elegans, By … A High-Fat Jelly Diet Restores Bioenergetic Balance And extends Lifespan In The Presence Of Motor Dysfunction And Lumbar Spinal Cord Motor Neuron Loss In Tdp … A Matter Of Life And Death: Discovering The Factors That Control The Lifespan Of The Cells That Form Blood Clots Could Improve Cancer Treatments And extend The Shelf-Life Of … A New Active Power‐Decoupling Topology And Control Mechanism To extend The Lifespan And Reduce The Number Of Passive Components A New Schizosaccharomyces Pombe Chronological Lifespan Assay Reveals That Caloric Restriction Promotes Efficient Cell Cycle Exit And extends Longevity A Novel Disease Caused By increase Of The Lifespan: Chronic Cutaneous Insufficiency Syndrome Or Dermatoporosis A Novel Endogenous Indole Protects Rodent Mitochondria And extends Rotifer Lifespan A Novel Gene, Ecl1+, extends The Chronological Lifespan In Fission Yeast A Novel Response To Cellular Hypoxia increases Lifespan In C. Elegans A Nutritional Supplement Containing Lactoferrin Stimulates The Immune System, extends Lifespan, And Reduces Amyloid Β Peptide Toxicity In Caenorhabditis Elegans A Parasite That increases Host Lifespan A Persistent Level Of Cisd2 extends Healthy Lifespan And Delays Aging In Mice A Reduction In Age-Enhanced Gluconeogenesis extends Lifespan A Regulated Response To Impaired Respiration Slows Behavioral Rates And increases Lifespan In Caenorhabditis Elegans A Salicylic Acid Derivative extends The Lifespan Of Caenorhabditis Elegans By Activating Autophagy And The Mitochondrial Unfolded Protein Response A Single Intrauterine Infusion Of Sustained Recombinant Ovine Interferon-Τ extends Corpus Luteum Lifespan In Cyclic Ewes A Small Molecule Modulator Of Prion Protein increases Human Mesenchymal Stem Cell Lifespan, Ex Vivo Expansion, And Engraftment To Bone Marrow In Nod/Scid Mice A Steroid Hormone That extends The Lifespan Of Caenorhabditis Elegans A Steroidal Saponin From Ophiopogon Japonicus extends The Lifespan Of Yeast Via The
A Circulatory Transcriptional Regulation Among Daf‐9, Daf‐12, And Daf‐16 Mediates Larval Development Upon Cholesterol Starvation In Caenorhabditis Elegans† A Conserved Neuronal Daf-16/Foxo Plays An Important Role In Conveying Pheromone Signals To Elicit Repulsion Behavior In Caenorhabditis Elegans A Daf‐16/Foxo3A‐Dependent Longevity Signal Is Initiated By Antioxidants A New Daf-16 Isoform Regulates Longevity A Review Of Genes That Act Downstream Of The Daf-16 Foxo Transcription Factor To Influence The Life Span Of C. Elegans Activation Of Daf-16/Foxo By Reactive Oxygen Species Contributes To Longevity In Long-Lived Mitochondrial Mutants In Caenorhabditis Elegans Activation Of The Caenorhabditis Elegans Foxo Family Transcription Factor Daf-16 By Pathogenic Bacillus Thuringiensis Activation Of The Foxo Family Transcription Factor Daf-16 By Pathogenic Bacillus Thuringiensis Adaptive Responses To Oxidative Damage In Three Mutants Of Caenorhabditis Elegans (Age-1, Mev-1 And Daf-16) That Affect Life Span Against Methicillin-Resistant Staphylococcus Aureus And Their Effects On Lys-7 Expression Of Innate Immune Pathway Daf-2/Daf-16 In Caenorhabditis Elegans Ages/Rage-Related Neurodegeneration: Daf-16 As A Mediator, Insulin As An Ameliorant, And C. Elegans As An Expedient Research Model Agrimonia Procera Wallr. Extract Increases Stress Resistance And Prolongs Life Span In Caenorhabditis Elegans Via Transcription Factor Daf-16 (Foxo Orthologue) Agro‐Industrial Waste Based Phycocyanin Production From Oscillatoria Sp. 50 A: Daf‐16 Modulating Effect In Caenorhabditis Elegans And P53 Dependent … Anthocyanin-Rich Purple Wheat Prolongs The Life Span Of Caenorhabditis Elegans Probably By Activating The Daf-16/Foxo Transcription Factor Antioxidative Activities Of Both Oleic Acid And Camellia Tenuifolia Seed Oil Are Regulated By The Transcription Factor Daf-16/Foxo In Caenorhabditis Elegans Apigenin Inhibits Larval Growth Of Caenorhabditis Elegans Through Daf‐16 Activation Arsenite Exposure Accelerates Aging Process Regulated By The Transcription Factor Daf-16/Foxo In Caenorhabditis Elegans Aspirin Extends The Lifespan Of Caenorhabditis Elegans Via Ampk And Daf-16/Foxo In Dietary Restriction Pathway Asymmetric Arginine Dimethylation Determines Life Span In C. Elegans By Regulating Forkhead Transcription Factor Daf-16 Baicalein Modulates Stress-Resistance And Life Span In C. Elegans Via Skn-1 But Not Daf-16 Benzimidazole Derivative M084 Extends The Lifespan Of Caenorhabditis Elegans In A Daf-16/Foxo-Dependent Way Betula Utilis Extract Prolongs Life Expectancy, Protects Against Amyloid-Β Toxicity And Reduces Alpha Synuclien In Caenorhabditis Elegans Via Daf-16 And Skn-1 Bioactive Peptides From Meretrix Meretrix Protect Caenorhabditis Elegans Against Free Radical-Induced Oxidative Stress Through The Stress Response Factor Daf-16 … Blueberry Extract Promotes Longevity And Stress Tolerance Via Daf-16 In Caenorhabditis Elegans C. Elegans 14-3-3 Proteins Regulate Life Span And Interact With Sir-2.1 And Daf-16/Foxo C. Elegans Daf-16/Foxo Interacts With Tgf-ß/Bmp Signaling To Induce Germline Tumor Formation Via Mtorc1 Activation C. Elegans Host Cell Factor (Cehcf) Associates With Sir-2.1 To Mediate Target Specificity Of Daf-16 And Lifespan C. Elegans Sir-2.1 Interacts With 14-3-3 Proteins To Activate Daf-16 And Extend Life Span C. Elegans Sirt6/7 Homolog Sir-2.4 Promotes Daf-16 Relocalization And Function During Stress Caenorhabditis Elegans Akt/Pkb Transduces Insulin Receptor-Like Signals From Age-1 Pi3 Kinase To The Daf-16 Transcription Factor Caenorhabditis Elegans Daf-16/Foxo Transcription Factor And Its Mammalian Homologs Associate With Age-Related Disease Caenorhabditis Elegans Eak-3 Inhibits Dauer Arrest Via Nonautonomous Regulation Of Nuclear Daf-16/Foxo Activity Caenorhabditis Elegans Hcf-1 Functions In Longevity
A Central Role For Stat3 In Il‐6‐Induced Regulation Of Growth And Differentiation In M1 Leukemia Cells. A High-Affinity Protein Binder That Blocks The Il-6/Stat3 Signaling Pathway Effectively Suppresses Non–Small Cell Lung Cancer A Muscle Specific Protein “Myoferlin” Modulates Il-6/Stat3 Signaling By Chaperoning Activated Stat3 To Nucleus A Muscle-Specific Protein 'Myoferlin'Modulates Il-6/Stat3 Signaling By Chaperoning Activated Stat3 To Nucleus A New Bioassay For Measuring The Strength Of Il-6/Stat3 Signal Inhibition By Tocilizumab In Patients With Rheumatoid Arthritis A Novel Anti-Cancer Agent Icaritin Suppresses Hepatocellular Carcinoma Initiation And Malignant Growth Through The Il-6/Jak2/Stat3 Pathway A Novel Positive Feedback Regulation Between Long Noncoding Rna Uicc And Il-6/Stat3 Signaling Promotes Cervical Cancer Progression A Novel Role For Histone Deacetylase 6 In The Regulation Of The Tolerogenic Stat3/Il-10 Pathway In Apcs A Novel Small Molecule, Lll12, Inhibits Il-6 Induced Stat3 Phosphorylation And Nuclear Translocation A Shift In The Il-6/Stat3 Signalling Pathway Imbalance Towards The Shp2 Pathway In Severe Asthma Results In Reduced Proliferation Process A Small Molecule, Lll12 Inhibits Constitutive Stat3 And Il‐6‐Induced Stat3 Signaling And Exhibits Potent Growth Suppressive Activity In Human Multiple Myeloma … A Socs-1 Peptide Mimetic Inhibits Both Constitutive And Il-6 Induced Activation Of Stat3 In Prostate Cancer Cells A Stat3/Nfκb Complex Is Necessary For The Expression Of Fascin In Metastatic Breast Cancer Cells In Response To Il-6 And Tnf-Α A Synthesis Of Novel Pyrazolylthienopyrimidine Derivatives As Il-6/Stat3 Inhibitors A1. 15 Il-6 Driven Stat3 Phosphorylation In Circulating Lymphocytes Is Specific For Cd4+ T Cells In Early Rheumatoid Arthritis A20 Promotes Liver Regeneration By Decreasing Socs3 Expression To Enhance Il‐6/Stat3 Proliferative Signals A63 Death To The Infidels! Cellular Apoptosis In Lung Disease: Notch Regulation Of Cell Density-Dependent Apoptosis Via Il-6/Stat3 Signaling Pathway Ab0040 Il-29 Induces Production Of Il-6 And Il-8 In Rheumatoid Arthritis Synovial Fibroblasts Via Jak/Stat3 And Mapk/Nf-Kb Signaling Pathways Ab0100 Mtx Combined With Ctx Inhibited Il-6 Induced Jak2-Stat3 Activation And The Induction Of P-Gp In Peripheral Blood Lymphocytes Of Rheumatoid Arthritis Patients Ab0214 Tlr2 Ligation Induces The Production Of Il-23/Il-17 Via Il-6, Stat3 And Nf-Kb Pathway In Patients With Primary Sjögren'S Syndrome Aberrant Expression Of Cul4A Is Associated With Il-6/Stat3 Activation In Colorectal Cancer Progression Aberrantly Expressed Fra-1 By Il-6/Stat3 Transactivation Promotes Colorectal Cancer Aggressiveness Through Epithelial–Mesenchymal Transition Abnormally Expressed Junb Transactivated By Il-6/Stat3 Signaling Promotes Uveal Melanoma Aggressiveness Via Epithelial–Mesenchymal Transition Abstract B36: Inhibition Of The Autocrine Il-6-Jak2-Stat3-Calprotectin Axis As Targeted Therapy For Hr-/Her2+ Breast Cancers Abstract B68: Targeted Inhibition Of Tgfβr2 Reduces Il-6 Production From Cancer-Associated Fibroblasts, Suppresses Stat3 Activation In Pancreatic Cancer Cells And … Abstract P2-06-07: Prkcq Regulates Taxol Sensitivity Of Triple Negative Breast Cancer Cells Via Il-6/Stat3 Signaling Abstract# 1154: Il-6 Induces Il-10 Expression And Promotes Cancer Progression After Activation Of Stat3 In Human Colon Carcinoma Cells Abstract# 1546: The Il-6/Jak2/Stat3 Signaling Pathway Upregulates Er-\# 946; Expression In Lung Adenocarcinoma Cells Abstract# 4893: Quantitative Phosphoproteomic Analysis Of Stat3/Il-6/Hif1\# 945; Signaling Partners In Ns11 Glioblastoma Stem Cells With Multiplexed Tandem Mass … Abstract# 5489: Sorafenib Inhibits Il-6 Induced Stat3 Signaling In Cholangiocarcinoma Cells And Demonstrates In
225Ac-Cd33 Radioimmunotherapy Potently Increases The Sensitivity Of Resistant Acute Myeloid Leukemia Lines To The Bcl-2 Inhibitor Venetoclax By Mediating A … 613 Poster Gx15-070, A Small Molecule Bcl-2 Family Inhibitor, Induces Apoptosis And Enhances Cisplatin-Induced Apoptosis In Non-Small Cell Lung Cancer … 8-Chrysoeriol, As A Potential Bcl-2 Inhibitor Triggers Apoptosis Of Sw1990 Pancreatic Cancer Cells A Functionally Improved Locked Nucleic Acid Antisense Oligonucleotide Inhibits Bcl-2 And Bcl-Xl Expression And Facilitates Tumor Cell Apoptosis A Literature Review Of The Patent Publications On Venetoclax–A Selective Bcl-2 Inhibitor: Discovering The Therapeutic Potential Of A Novel Chemotherapeutic Agent A Novel Bcl-2 Inhibitor, Bm-1197, Induces Apoptosis In Malignant Lymphoma Cells Through The Endogenous Apoptotic Pathway A Novel Bcl-2 Small Molecule Inhibitor 4-(3-Methoxy-Phenylsulfannyl)-7-Nitro-Benzofurazan-3-Oxide (Mnb)-Induced Apoptosis In Leukemia Cells A Novel Small Molecule Inhibitor Targeted At Bcl-2 A Phase 1B/2 Clinical Study Of Targeted Idh1 Inhibition With Ivosidenib, In Combination With The Bcl-2 Inhibitor Venetoclax, For Patients With Idh1-Mutated (Midh1) … A Phase I Study Of The Pan Bcl-2 Family Inhibitor Obatoclax Mesylate In Patients With Advanced Hematologic Malignancies A Phase I Trial Of The Small Molecule Pan-Bcl-2 Inhibitor Obatoclax (Gx15–070) In Combination With Docetaxel In Patients With Relapsed Non-Small Cell Lung Cancer … A Phase Ib/Ii Study Of The Bcl-2 Inhibitor Venetoclax In Combination With Standard Intensive Aml Induction/Consolidation Therapy With Flag-Ida In Patients With … A Safety And Schedule Seeking Trial Of Bcl-2 Inhibitor Obatoclax In Previously Untreated Older Patients With Acute Myeloid Leukemia (Aml) A Small Molecule Inhibitor Of Bcl-2, Ha14-1, Also Inhibits Ceramide Glucosyltransferase A Small Molecule Pan-Bcl-2 Family Inhibitor, Gx15-070, Induces Apoptosis And Enhances Cisplatin-Induced Apoptosis In Non-Small Cell Lung Cancer Cells A64 Cells Run A-Muc: Mucin Biology In The Lung: A Small Molecule Bcl-2 Inhibitor Switches Il-13 To A Cell Death Inducer For Allergen-Induced Metaplastic … Aberrantly Expressed Fra-1 By Il-6/Stat3 Transactivation Promotes Colorectal Cancer Aggressiveness Through Epithelial–Mesenchymal Transition Absorption, Metabolism, And Excretion Of A Novel Bcl-2 Inhibitor Venetoclax In Humans Abstract A245: Combination Of The Glycoengineered Type Ii Cd20 Antibody Obinutuzumab (Ga101), And The Novel Bcl-2 Selective Inhibitor, Abt-199 (Gdc-0199) … Abstract A30: Inhibition Of Pmca4 As A Strategy To Increase The Effectiveness Of Bcl-2 Inhibitor-Mediated Cell Death In Breast Cancer Cells. Abstract A77: Repression Of Mtorc1 Activity In Notch1 Mutant T-All Results In Sensitivity To The Bcl-2 Inhibitor Abt-263 Abstract B4: A Microrna Screen To Identify Modulators Of Sensitivity To Bcl-2 Inhibitor Abt-263 Abstract Ct069: Correlative Biomarkers Of Clinical Activity Of The Bcl-2 Inhibitor, Venetoclax (Abt-199/Gdc-0199), In Acute Myeloid Leukemia Patients Abstract Lb-212: Mcl-1 And Fbw7 Control A Dominant Survival Pathway Underlying Hdac And Bcl-2 Inhibitor Synergy In Squamous Cell Carcinoma. Abstract Lb-72: An Immunoassay Detecting Bcl-2: Bim And Mcl-1: Bim Complexes In The Phase 1 Monotherapy Study Of The Bcl-2 Inhibitor, Abt-199/Gdc-0199, In … Abstract Pd1-06: A Phase 1B Dose-Escalation And Expansion Study Of The Bcl-2 Inhibitor Venetoclax Combined With Tamoxifen In Er And Bcl-2–Positive Metastatic … Abstract# 3990: The Pan-Bcl-2 Family Inhibitor Abt-737 Synergizes With Dna Damaging Agents By Enhancing Apoptosis In Acute Lymphoblastic Leukemia Cells Abt-199,
A Hopeful Natural Product, Pristimerin, Induces Apoptosis, Cell Cycle Arrest, And Autophagy In Esophageal Cancer Cells Aberrantly Expressed Fra-1 By Il-6/Stat3 Transactivation Promotes Colorectal Cancer Aggressiveness Through Epithelial–Mesenchymal Transition Acquisition Of Resistance To Trastuzumab In Gastric Cancer Cells Is Associated With Activation Of Il-6/Stat3/Jagged-1/Notch Positive Feedback Loop Activation Of Stat3 In Human Gastric Cancer Cells Via Interleukin (Il)-6-Type Cytokine Signaling Correlates With Clinical Implications Anticancer Activity Of Pristimerin In Epidermal Growth Factor Receptor 2-Positive Skbr3 Human Breast Cancer Cells Anticancer Activity Of Pristimerin In Ovarian Carcinoma Cells Is Mediated Through The Inhibition Of Prosurvival Akt/Nf-Κb/Mtor Signaling Anticancer Potential And Molecular Targets Of Pristimerin: A Mini-Review Anticytomegalovirus Activity Of Pristimerin, A Triterpenoid Quinone Methide Isolated From Maytenus Heterophylla (Eckl. & Zeyh.) Antifungal Activity Of Maytenin And Pristimerin Antifungal Properties Of Pristimerin And Celastrol Isolated From Celastrus Hypoleucus Anti-Inflammatory Effect Of Pristimerin On Lipopolysaccharide-Induced Inflammatory Responses In Murine Macrophages Antiproliferative Activity Of Pristimerin Isolated From Maytenus Ilicifolia (Celastraceae) In Human Hl-60 Cells Antitumoral, Mutagenic And (Anti) Estrogenic Activities Of Tingenone And Pristimerin Aspirin Induces Apoptosis Through The Blockade Of Il-6-Stat3 Signaling Pathway In Human Glioblastoma A172 Cells Aspirin Promotes Apoptosis In A Murine Model Of Colorectal Cancer By Mechanisms Involving Downregulation Of Il-6–Stat3 Signaling Pathway Autocrine Il-6-Induced Stat3 Activation Contributes To The Pathogenesis Of Lung Adenocarcinoma And Malignant Pleural Effusion Combination Of Pristimerin And Paclitaxel Additively Induces Autophagy In Human Breast Cancer Cells Via Erk1/2 Regulation Deletion Of The Innate Immune Nlrp3 Receptor Abolishes Cardiac Ischemic Preconditioning And Is Associated With Decreased Il-6/Stat3 Signaling Dna Damage Induces The Il-6/Stat3 Signaling Pathway, Which Has Anti-Senescence And Growth-Promoting Functions In Human Tumors Dysregulated Mir-124 And Mir-200 Expression Contribute To Cholangiocyte Proliferation In The Cholestatic Liver By Targeting Il-6/Stat3 Signalling Embelin Reduces Colitis-Associated Tumorigenesis Through Limiting Il-6/Stat3 Signaling Epigenetic Alterations In Cholangiocarcinoma-Sustained Il-6/Stat3 Signaling In Cholangio-Carcinoma Due To Socs3 Epigenetic Silencing Hepatic Acute Phase Proteins–Regulation By Il-6-And Il-1-Type Cytokines Involving Stat3 And Its Crosstalk With Nf-Κb-Dependent Signaling Hmgb1-Il-23-Il-17-Il-6-Stat3 Axis Promotes Tumor Growth In Murine Models Of Melanoma Hplc Profile And Simultaneous Quantitative Analysis Of Tingenone And Pristimerin In Four Celastraceae Species Using Hplc-Uv-Dad-Ms Il-17 Induces Akt-Dependent Il-6/Jak2/Stat3 Activation And Tumor Progression In Hepatocellular Carcinoma Il-6 Promotes Head And Neck Tumor Metastasis By Inducing Epithelial–Mesenchymal Transition Via The Jak-Stat3-Snail Signaling Pathway Il-6 Trans-Signaling Modulates Tlr4-Dependent Inflammatory Responses Via Stat3 Il-6 Trans-Signaling Via Stat3 Directs T Cell Infiltration In Acute Inflammation Il-6/Stat3/Tff3 Signaling Regulates Human Biliary Epithelial Cell Migration And Wound Healing In Vitro Il-6–Gp130–Stat3 In T Cells Directs The Development Of Il-17+ Th With A Minimum Effect On That Of Treg In The Steady State Improved Extraction Of The Natural Anticancerigen Pristimerin From Mortonia Greggii Root Bark Using Green Solvents And Aqueous Two-Phase Systems Inducible Microrna-223 Down-Regulation Promotes Tlr-Triggered Il-6 And Il-1Β Production In Macrophages By Targeting Stat3 Induction Of Cell‐Cycle Arrest And Apoptosis In Human Cholangiocarcinoma Cells By Pristimerin Inhibition Of Htert In Pancreatic Cancer Cells By Pristimerin Involves Suppression Of Epigenetic Regulators Of Gene Transcription Inhibition Of Il-6/Stat3 Axis And Targeting Axl And Tyro3
A cell-permeable STAT3 SH2 domain mimetic inhibitor of STAT3 activation inhibits growth of human breast tumor xenografts A cell-permeable STAT3 SH2 domain mimetic inhibits STAT3 activation and induces antitumor cell effects in vitro A low-molecular-weight compound discovered through virtual database screening inhibits STAT3 function in breast cancer cells A membrane penetrating peptide aptamer inhibits STAT3 function and suppresses the growth of STAT3 addicted tumor cells A millet bran-derived peroxidase inhibits cell migration by antagonizing STAT3-mediated epithelial-mesenchymal transition in human colon cancer A natural compound derivative P-13 inhibits STAT3 signaling by covalently inhibiting Janus kinase 2 A novel curcumin analog inhibits canonical and non-canonical functions of telomerase through STAT3 and NF-κB inactivation in colorectal cancer cells A novel imidazole derivate inhibits STAT3 activation via induction of SHP-1 hepatocellular carcinoma A novel non-phosphorylated potential antitumoral peptide inhibits STAT3 biological activity A novel platinum compound inhibits constitutive STAT3 signaling and induces cell cycle arrest and apoptosis of malignant cells A novel small molecular STAT3 inhibitor, LY5, inhibits cell viability, cell migration, and angiogenesis in medulloblastoma cells A novel small molecule inhibits STAT3 phosphorylation and DNA binding activity and exhibits potent growth suppressive activity in human cancer cells A novel small molecule STAT3 inhibitor, LY5, inhibits cell viability, colony formation, and migration of colon and liver cancer cells A novel small molecule, LLL12, inhibits IL-6 induced STAT3 phosphorylation and nuclear translocation A novel small molecule, LLL12, inhibits STAT3 phosphorylation and activities and exhibits potent growth-suppressive activity in human cancer cells A novel small molecule, LY5, selectively inhibits STAT3 phosphorylation and activities and exhibits potent growth suppressive activity in cancer cells. A novel synthetic Asiatic acid derivative induces apoptosis and inhibits proliferation and mobility of gastric cancer cells by suppressing STAT3 signaling … A phosphopeptide mimetic prodrug targeting the SH2 domain of STAT3 inhibits tumor growth and angiogenesis A serine protease extracted from Trichosanthes kirilowii inhibits epithelial-mesenchymal transition via antagonizing PKM2-mediated STAT3/Snail1 pathway in human … A small molecule compound targeting STAT3 DNA-binding domain inhibits cancer cell proliferation, migration, and invasion A small molecule, LLL12 inhibits constitutive STAT3 and IL‐6‐induced STAT3 signaling and exhibits potent growth suppressive activity in human multiple myeloma … Abstract B95: A novel small molecule, LLL12 inhibits STAT3 phosphorylation and activities and exhibits potent growth suppressive activity in human hepatocellular … Abstract P6-14-13: A Flavone from Traditional East Asian Natural Extract Inhibits STAT3 and Tumor Growth in a Syngeneic Mouse Breast Cancer Model Abstract# 3693: Sorafenib inhibits STAT3-regulated expression of prosurvival Mcl-1 and Bcl-xL proteins to enhance TRAIL-mediated apoptosis in human pancreatic … Abstract# 5627: Sorafenib inhibits STAT3 signaling, cell proliferation and survival of human glioblastomas Allicin Inhibits Proliferation and Invasion in Vitro and in Vivo via SHP-1-Mediated STAT3 Signaling in Cholangiocarcinoma An ethanolic extract of ampelopsis radix exerts anti-colorectal cancer effects and potently inhibits STAT3 signaling in vitro APE1/Ref-1 regulates STAT3 transcriptional activity and APE1/Ref-1–STAT3 dual-targeting effectively inhibits pancreatic cancer cell survival Aphanin, a triterpenoid from Amoora rohituka inhibits K-Ras mutant activity and STAT3 in pancreatic carcinoma cells Apigenin inhibits
Beclin-1 is a crucial protein for autophagy, a cellular housekeeping process that cleans out damaged organelles and proteins. This recycling system is essential for maintaining healthy cells and tissues throughout the body. Studies have shown that reduced Beclin-1 levels and impaired autophagy are linked to various age-related diseases like Alzheimer's and Parkinson's. The theory is that malfunctioning autophagy allows harmful protein aggregates and dysfunctional organelles to accumulate, leading to cellular stress and eventually, disease. Conversely, research suggests that activating autophagy through Beclin-1 or other pathways might promote healthy aging by enhancing cellular cleaning and preventing the buildup of damage. While the exact mechanisms are still under investigation, understanding the interplay between Beclin-1, autophagy, and aging holds promise for developing future interventions to promote cellular health and longevity. A Distinct Pattern of Beclin-1 Staining Helps Distinguish Sessile Serrated Adenomas A non-canonical MEK/ERK signaling pathway regulates autophagy via regulating Beclin 1 A novel role of Beclin-1, cytokinetic abscission A phosphatidylinositol 3-kinase class III sub-complex containing VPS15, VPS34, Beclin 1, UVRAG and BIF-1 regulates cytokinesis and degradative endocytic traffic A pivotal role of FOS-mediated BECN1/Beclin 1 upregulation in dopamine D2 and D3 receptor agonist-induced autophagy activation A role for autophagic protein Beclin 1 early in lymphocyte development A tumor-associated mutation of FYVE-CENT prevents its interaction with Beclin 1 and interferes with cytokinesis A179L, a new viral Bcl2 homolog targeting Beclin 1 autophagy related protein A6799 Ginsenoside Rb1 alleviate ox-LDL induced HUVEC senescence via SIRT1/Beclin-1/autophagy axis A80-C MOLECULAR AND IMMUNOBIOLOGY OF LUNG CANCER: High Levels Of Beclin-1 In Induced Sputum Of Lung Cancer Patients As A Marker Of Increased … Aberrant autolysosomal regulation is linked to the induction of embryonic senescence: differential roles of Beclin 1 and p53 in vertebrate Spns1 deficiency Aberrant Beclin 1 expression is closely linked to carcinogenesis, differentiation, progression, and prognosis of ovarian epithelial carcinoma Aberrant expression of Beclin-1 and LC3 correlates with poor prognosis of human hypopharyngeal squamous cell carcinoma Abstract C150: CaMKKβ-mediated phosphorylation of Beclin 1 regulates autophagy and cell differentiation in neuroblastoma cells. Abstract P046: Hsp20 Promotes Cardiac autophagy via Interaction with Beclin-1 Abstract# 1872: Mechanistic role of acetylated heat shock protein 70 in the VPS34/Beclin-1 triggered autophagy in breast cancer cells Abstract# 387: Regulation of autophagy by the Beclin 1-targeted microRNA in cancer cells Abstract# 867: Beclin 1 augments the action of a polyamine analogue in MCF-7 breast cancer cells Acetylation of Beclin 1 inhibits autophagosome maturation and promotes tumour growth Activating transcription factor 3 protects against pressure-overload heart failure via the autophagy molecule Beclin-1 pathway Activation of RIG-I-mediated antiviral signaling triggers autophagy through the MAVS-TRAF6-Beclin-1 signaling axis Acute phase expression pattern of ZnTs, LC3, and Beclin-1 in rat Hippocampus and its regulation by 3-methyladenine following recurrent neonatal seizures Adiponectin inhibits inflammatory cytokines production by Beclin‐1 phosphorylation and B‐cell lymphoma 2 mRNA destabilization: role for autophagy induction Age-dependent molecular alterations in the autophagy pathway in HIVE patients and in a gp120 tg mouse model: reversal with Beclin-1 gene transfer Akt-Mediated Regulation of autophagy and Tumorigenesis Through