GSK3 inhibitors: development and therapeutic potential The conundrum of GSK3 inhibitors: is it the dawn of a new beginning? Discovery and development of GSK3 inhibitors for the treatment of type 2 diabetes GSK3 inhibitors and disease GSK3 inhibitors show benefits in an Alzheimer's disease (AD) model of neurodegeneration but adverse effects in control animals GSK3 inhibitors in the therapeutic development of diabetes, cancer and neurodegeneration: past, present and future Immune checkpoint inhibition in syngeneic mouse cancer models by a silicasome nanocarrier delivering a GSK3 inhibitor The development of potent and selective bisarylmaleimide GSK3 inhibitors Cytotoxicity and activation of the Wnt/beta-catenin pathway in mouse embryonic stem cells treated with four GSK3 inhibitors Activation of Wnt/β-catenin signalling via GSK3 inhibitors direct differentiation of human adipose stem cells into functional hepatocytes Effects of GSK3 inhibitors on in vitro expansion and differentiation of human adipose-derived stem cells into adipocytes A modified EpiSC culture condition containing a GSK3 inhibitor can support germline-competent pluripotency in mice The selective GSK3 inhibitor, SAR502250, displays neuroprotective activity and attenuates behavioral impairments in models of neuropsychiatric symptoms of … GSK3 Inhibitors Regulate MYCN mRNA Levels and Reduce Neuroblastoma Cell Viability through Multiple Mechanisms, Including p53 and Wnt Signaling Rats treated with AZD2858, a GSK3 inhibitor, heal fractures rapidly without endochondral bone formation Oral administration of a GSK3 inhibitor increases brain insulin-like growth factor I levels GSK3 inhibitor-induced dentinogenesis using a hydrogel QSAR, docking, and CoMFA studies of GSK3 inhibitors GSK3 inhibitor-BIO regulates proliferation of immortalized pancreatic mesenchymal stem cells (iPMSCs) GSK3 inhibitor-loaded osteotropic Pluronic hydrogel effectively mitigates periodontal tissue damage associated with experimental periodontitis GSK3 inhibitors CHIR99021 and 6-bromoindirubin-3′-oxime inhibit microRNA maturation in mouse embryonic stem cells Testing Fmr1KO Phenotypes in Response to GSK3 Inhibitors: SB216763 versus AFC03127 From on‐target to off‐target activity: identification and optimisation of Trypanosoma brucei GSK3 inhibitors and their characterisation as anti‐Trypanosoma brucei drug … Donor cell engineering with GSK3 inhibitor–loaded nanoparticles enhances engraftment after in utero transplantation Evidence for antimanic efficacy of glycogen synthase kinase-3 (GSK3) inhibitors in a strain-specific model of acute mania GSK3 inhibitor ameliorates steatosis through the modulation of mitochondrial dysfunction in hepatocytes of obese patients GSK3 inhibitors enhance retinoic acid receptor activity and induce the differentiation of retinoic acid-sensitive myeloid leukemia cells EGF and a GSK3 inhibitor deplete junctional E-cadherin and stimulate proliferation in the mature mammalian ear Control of Hes7 Expression by Tbx6, the Wnt Pathway and the Chemical Gsk3 Inhibitor LiCl in the Mouse Segmentation Clock Glycogen synthase kinase 3 (GSK3) inhibitor, SB-216763, promotes pluripotency in mouse embryonic stem cells The GSK3 kinase inhibitor lithium produces unexpected hyperphosphorylation of β-catenin, a GSK3 substrate, in human glioblastoma cells Stable generation of serum‐and feeder‐free embryonic stem cell‐derived mice with full germline‐competency by using a GSK3 specific inhibitor The novel potent GSK3 inhibitor AF3581 reverts fragile X syndrome phenotype Effect of Gsk3 inhibitor CHIR99021 on aneuploidy levels in rat embryonic stem cells GSK3 inhibitors stabilize Wee1 and reduce cerebellar granule cell progenitor proliferation Three inhibitors of FGF receptor, ERK, and GSK3 establishes germline‐competent embryonic
SIRT1 suppresses activator protein-1 transcriptional activity and cyclooxygenase-2 expression in macrophages Sirt 1 activator inhibits the AGE-induced apoptosis and p53 acetylation in human vascular endothelial cells Cardiovascular effects of a novel SIRT 1 activator, SRT 2104, in otherwise healthy cigarette smokers The SIRT1 activator resveratrol protects SK‐N‐BE cells from oxidative stress and against toxicity caused by α‐synuclein or amyloid‐β (1‐42) peptide Role of deleted in breast cancer 1 (DBC1) protein in SIRT1 deacetylase activation induced by protein kinase A and AMP-activated protein kinase Nobiletin ameliorates hepatic ischemia and reperfusion injury through the activation of SIRT-1/FOXO3a-mediated autophagy and mitochondrial biogenesis SIRT 1‐mediated epigenetic downregulation of plasminogen activator inhibitor‐1 prevents vascular endothelial replicative senescence PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation Treadmill exercise decreases amyloid-β burden possibly via activation of SIRT-1 signaling in a mouse model of Alzheimer's disease Sirtuin 1 (SIRT1) protein degradation in response to persistent c-Jun N-terminal kinase 1 (JNK1) activation contributes to hepatic steatosis in obesity A novel biological role of α‐mangostin in modulating inflammatory response through the activation of SIRT‐1 signaling pathway Two novel SIRT1 activators, SCIC2 and SCIC2. 1, enhance SIRT1-mediated effects in stress response and senescence Peroxisome proliferator-activated receptor γ co-activator 1α (PGC-1α) and sirtuin 1 (SIRT1) reside in mitochondria: possible direct function in mitochondrial … SIRT1/PGC-1 pathway activation triggers autophagy/mitophagy and attenuates oxidative damage in intestinal epithelial cells Probing the mechanism of SIRT1 activation by a 1, 4-dihydropyridine Melatonin attenuates acute kidney ischemia/reperfusion injury in diabetic rats by activation of the SIRT1/Nrf2/HO-1 signaling pathway Involvement of TACE in colon inflammation: a novel mechanism of regulation via SIRT-1 activation Nutraceutical activators of AMPK/Sirt1 axis inhibit viral production and protect neurons from neurodegenerative events triggered during HSV-1 infection Pharmacokinetics and tolerability of SRT 2104, a first‐in‐class small molecule activator of SIRT 1, after single and repeated oral administration in man Sirtuin 1 (SIRT1) activation mediates sildenafil induced delayed cardioprotection against ischemia-reperfusion injury in mice PARP-1 inhibition protects the diabetic heart through activation of SIRT1-PGC-1α axis SIRT1 silencing confers neuroprotection through IGF‐1 pathway activation Induction of autophagy and activation of SIRT‐1 deacetylation mechanisms mediate neuroprotection by the pomegranate metabolite urolithin A in BV2 microglia and … SirT1 activator represses the transcription of TNF‑α in THP‑1 cells of a sepsis model via deacetylation of H4K16 Parthenolide Phytosomes Attenuated Gentamicin-Induced Nephrotoxicity in Rats via Activation of Sirt-1, Nrf2, OH-1, and NQO1 Axis SIRT 1 activator loaded inhaled antiangiogenic liposomal formulation development for pulmonary hypertension Oligo-fucoidan improves diabetes-induced renal fibrosis via activation of sirt-1, glp-1r, and nrf2/ho-1: An in vitro and in vivo study Inhibition of SIRT1 by HIV-1 viral protein Tat results in activation of p53 pathway α-Lipoic acid regulates lipid metabolism through induction of sirtuin 1 (SIRT1) and activation of AMP-activated protein kinase Sirt 1 activator attenuates the bleomycin-induced lung fibrosis in mice via inhibiting epithelial-to-mesenchymal transition (EMT). Homocysteine facilitates LOX-1 activation and endothelial death through the PKCβ and SIRT1/HSF1 mechanism: relevance to human hyperhomocysteinaemia … Effect of DiDang Tang Against AlCl3-Induced Oxidative Stress and Apoptosis in PC12 Cells Through
AMPK activation: a therapeutic target for type 2 diabetes? AMPK activators–potential therapeutics for metabolic and other diseases AMPK activation, a preventive therapeutic target in the transition from cardiac injury to heart failure Choreography of AMPK activation Use of cells expressing γ subunit variants to identify diverse mechanisms of AMPK activation Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome Effect of AMPK activation on muscle glucose metabolism in conscious rats AMP as a low-energy charge signal autonomously initiates assembly of AXIN-AMPK-LKB1 complex for AMPK activation A redox-dependent mechanism for regulation of AMPK activation by Thioredoxin1 during energy starvation Prognostic significance of AMPK activation and therapeutic effects of metformin in hepatocellular carcinoma Antileukemic effects of AMPK activators on BCR-ABL–expressing cells Anti-diabetic and anti-lipidemic effects of chlorogenic acid are mediated by ampk activation A small molecule AMPK activator protects the heart against ischemia–reperfusion injury SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function Hypoxia triggers AMPK activation through reactive oxygen species-mediated activation of calcium release-activated calcium channels Metformin amplifies chemotherapy-induced AMPK activation and antitumoral growth Berberine suppresses proinflammatory responses through AMPK activation in macrophages Activation of autophagy in human skeletal muscle is dependent on exercise intensity and AMPK activation Starvation-induced autophagy is regulated by mitochondrial reactive oxygen species leading to AMPK activation Predominant α2/β2/γ3 AMPK activation during exercise in human skeletal muscle Sestrin2 promotes LKB1-mediated AMPK activation in the ischemic heart Therapeutic metformin/AMPK activation blocked lymphoma cell growth via inhibition of mTOR pathway and induction of autophagy Berberine-induced apoptotic and autophagic death of HepG2 cells requires AMPK activation Suppression of AMPK activation via S485 phosphorylation by IGF-I during hyperglycemia is mediated by AKT activation in vascular smooth muscle cells Structural basis for AMPK activation: natural and synthetic ligands regulate kinase activity from opposite poles by different molecular mechanisms AMPK activator AICAR ameliorates ischaemia reperfusion injury in the rat kidney Gain-of-function mutant p53 promotes cell growth and cancer cell metabolism via inhibition of AMPK activation Structural basis of AMPK regulation by small molecule activators Chlorogenic acid stimulates glucose transport in skeletal muscle via AMPK activation: a contributor to the beneficial effects of coffee on diabetes Resveratrol promotes autophagic cell death in chronic myelogenous leukemia cells via JNK-mediated p62/SQSTM1 expression and AMPK activation AICAR, an AMPK activator, has protective effects on alcohol‐induced fatty liver in rats AMPK activation—protean potential for boosting healthspan Potential AMPK activators of cucurbitane triterpenoids from Siraitia grosvenorii Swingle Nilotinib induces autophagy in hepatocellular carcinoma through AMPK activation Resveratrol modulates tumor cell proliferation and protein translation via SIRT1-dependent AMPK activation AMP-activated protein kinase (AMPK) activators from Myristica fragrans (nutmeg) and their anti-obesity effect AMPK activation regulates neuronal structure in developing hippocampal neurons AMPK activation of muscle autophagy prevents fasting-induced hypoglycemia and myopathy during aging AMPK activation regulates apoptosis, adipogenesis, and lipolysis by eIF2α in adipocytes AMPK activators suppress cervical cancer cell growth through inhibition of DVL3 mediated Wnt/β-catenin signaling activity Berberine-induced AMPK activation
Molecular mechanism of nrf2 activation by oxidative stress The pathways and molecular mechanisms regulating Nrf2 activation in response to chemical stress Natural Nrf2 activators in diabetes Nrf2 activation as target to implement therapeutic treatments Oxidative stress in health and disease: the therapeutic potential of Nrf2 activation Mechanism of chemical activation of Nrf2 Therapeutic potential of Nrf2 activators in streptozotocin-induced diabetic nephropathy Nrf2 activators as attractive therapeutics for diabetic nephropathy Effect of redox modulating NRF2 activators on chronic kidney disease Combating oxidative stress in diabetic complications with Nrf2 activators: how much is too much? CUL3 and NRF2 Mutations Confer an NRF2 Activation Phenotype in a Sporadic Form of Papillary Renal Cell Carcinoma The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress Probing the structural requirements of non-electrophilic naphthalene-based Nrf2 activators Effect of Nrf2 activators on release of glutathione, cysteinylglycine and homocysteine by human U373 astroglial cells Nrf2 signaling in coordinated activation of antioxidant gene expression Temporal activation of Nrf2 in the penumbra and Nrf2 activator-mediated neuroprotection in ischemia–reperfusion injury Molecular mechanism of human Nrf2 activation and degradation: role of sequential phosphorylation by protein kinase CK2 Acute oxidative stress and systemic Nrf2 activation by the ketogenic diet Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation Nrf2 activation: a potential strategy for the prevention of acute mountain sickness Development of Neh2-luciferase reporter and its application for high throughput screening and real-time monitoring of Nrf2 activators NRF2 activation is involved in ozonated human serum upregulation of HO-1 in endothelial cells Sulforaphane protects against cardiovascular disease via Nrf2 activation Nrf2 activation prevents cadmium-induced acute liver injury Specific patterns of electrophile adduction trigger Keap1 ubiquitination and Nrf2 activation The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer Nrf2 activation in astrocytes protects against neurodegeneration in mouse models of familial amyotrophic lateral sclerosis Nrf2 activation protects the liver from ischemia/reperfusion injury in mice Novel chalcone derivatives as potent Nrf2 activators in mice and human lung epithelial cells Keap1‐Nrf2 activation in the presence and absence of DJ‐1 Genetic alteration of Keap1 confers constitutive Nrf2 activation and resistance to chemotherapy in gallbladder cancer Nrf2 activators attenuate the progression of nonalcoholic steatohepatitis–related fibrosis in a dietary rat model miR-200a regulates Nrf2 activation by targeting Keap1 mRNA in breast cancer cells Role of impaired Nrf2 activation in the pathogenesis of oxidative stress and inflammation in chronic tubulo-interstitial nephropathy Nrf2 activation protects against solar-simulated ultraviolet radiation in mice and humans Transcription factor Nrf2 activation by inorganic arsenic in cultured keratinocytes: involvement of hydrogen peroxide A noncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62 Effect of graded Nrf2 activation on phase-I and-II drug metabolizing enzymes and transporters in mouse liver Amelioration of inflammation and tissue damage in sickle cell model mice by Nrf2 activation Abbott boosts investment in NRF2 activators for reducing oxidative stress Involvement of Nrf2 activation in resistance to 5-fluorouracil in human colon cancer HT-29 cells Activation of hepatic Nrf2 in vivo by acetaminophen in CD‐1 mice Cinnamoyl-based
Immunoregulatory functions of mTOR inhibition Dissecting the role of mTOR: lessons from mTOR inhibitors Updates of mTOR inhibitors mTOR inhibitors: an overview The pharmacology of mTOR inhibition Current development of mTOR inhibitors as anticancer agents Functional consequences of mTOR inhibition mTOR inhibitors in the treatment of cancer Will mTOR inhibitors make it as cancer drugs? mTOR pathway and mTOR inhibitors as agents for cancer therapy Deforolimus (AP23573) a novel mTOR inhibitor in clinical development mTOR inhibitor/proliferation signal inhibitors: entering or leaving the field? The biology behind mTOR inhibition in sarcoma Targeting tumorigenesis: development and use of mTOR inhibitors in cancer therapy Predicted mechanisms of resistance to mTOR inhibitors mToR inhibitors-induced proteinuria: mechanisms, significance, and management mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt The applicability of mTOR inhibition in solid tumors Enhanced radiation damage of tumor vasculature by mTOR inhibitors The potential role of mTOR inhibitors in non-small cell lung cancer A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma The role of mTOR inhibitors in the management of posttransplant malignancy Overcoming mTOR inhibition-induced paradoxical activation of survival signaling pathways enhances mTOR inhibitors' anticancer efficacy Vascular remodeling and antitumoral effects of mTOR inhibition in a rat model of hepatocellular carcinoma mTOR inhibitor‐associated dermatologic and mucosal problems DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival mTOR inhibitor RAD001 (everolimus) has antiangiogenic/vascular properties distinct from a VEGFR tyrosine kinase inhibitor The mTOR inhibitor RAD001 sensitizes tumor cells to DNA-damaged induced apoptosis through inhibition of p21 translation PI3K/AKT/mTOR inhibitors in ovarian cancer mTOR, a novel target in breast cancer: the effect of CCI-779, an mTOR inhibitor, in preclinical models of breast cancer. mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways Prospects for mTOR inhibitor use in patients with polycystic kidney disease and hamartomatous diseases PI3K and mTOR inhibitors—a new generation of targeted anticancer agents Effects of the mTOR inhibitor sirolimus in patients with hepatocellular and cholangiocellular cancer The emerging safety profile of mTOR inhibitors, a novel class of anticancer agents Overcoming cisplatin resistance by mTOR inhibitor in lung cancer Pilot study of the combination of EGFR and mTOR inhibitors in recurrent malignant gliomas Oral mTOR inhibitor everolimus in patients with gemcitabine-refractory metastatic pancreatic cancer Novel and evolving therapies in the treatment of malignant phaeochromocytoma: experience with the mTOR inhibitor everolimus (RAD001) Combination of the mTOR inhibitor rapamycin and CC-5013 has synergistic activity in multiple myeloma Biochemical correlates of mTOR inhibition by the rapamycin ester CCI-779 and tumor growth inhibition A Phase II trial of the oral mTOR inhibitor everolimus in relapsed Hodgkin lymphoma Initial testing (stage 1) of the mTOR inhibitor rapamycin by the pediatric preclinical testing program mTOR inhibitors in polycystic kidney disease mTOR inhibitors are synergistic with methotrexate: an effective combination to treat acute lymphoblastic leukemia Biomarker development for the clinical activity of the mTOR inhibitor everolimus (RAD001): processes, limitations, and further proposals Treatment with the mTOR inhibitor temsirolimus in patients with malignant
Reversal of obesity by targeted ablation of adipose tissue Reversal of Obesity- and Diet-Induced Insulin Resistance with Salicylates or Targeted Disruption of Ikkβ Reversal of obesity-related hypoadiponectinemia by lifestyle intervention: a controlled, randomized study in obese adolescents Reversal of diet-induced obesity and diabetes in C57BL/6J mice Appearance of brown adipocytes in white adipose tissue during CL 316,243-induced reversal of obesity and diabetes in Zucker fa/fa rats Leptin Activation of Corticosterone Production in Hepatocytes May Contribute to the Reversal of Obesity and Hyperglycemia in Leptin-Deficient ob/ob Mice Hypertrophy of brown adipocytes in brown and white adipose tissues and reversal of diet-induced obesity in rats treated with a β3-adrenoceptor agonist Trends in fatness and the origins of obesity Reversal of obesity in the genetically obese fa/fa Zucker rat with an ephedrine/methylxanthines thermogenic mixture Reversal of Obesity-and Diet-Induced Insulin Resistance with Salicylates or Targeted Disruption.... Mifepristone (RU 486), a blocker of type II glucocorticoid and progestin receptors, reverses a dietary form of obesity Obesity and sarcopenia after menopause are reversed by sex hormone replacement therapy Myocardial fatty acid oxidation rates remain elevated in ob/ob mice despite reversal of obesity and diabetes by caloric restriction Specificity of Leptin Action on Elevated Blood Glucose Levels and Hypothalamic Neuropeptide Y Gene Expression in ob/ob Mice Body weight regulation in obese and obese-reduced rats. Inflammation and the IKKβ/IκB/NF-κB axis in obesity-and diet-induced insulin resistance Polycythemia of obesity: further studies of its mechanism and a report of two additional cases Brain responses to obesogenic diets and diet-induced obesity Development of obesity in transgenic mice after genetic ablation of brown adipose tissue Hypothalamic obesity: the autonomic hypothesis and the lateral hypothalamus Role of Endoplasmic Reticulum Stress and c-Jun NH2-Terminal Kinase Pathways in Inflammation and Origin of Obesity and Diabetes Severe orthostatic hypotension following weight reduction surgery The role of beta3-adrenergic receptors in control of brown and white adipose tissues and of energy balance: Reversal of obesity by CL 316,243, a new beta3 … Strategies for the delivery of leptin to the CNS Mouse models of lipodystrophy: Key reagents for the understanding of the metabolic syndrome The liver in obesity and type 2 diabetes mellitus Effects of fasting and refeeding on blood pressure are determined by nutritional state, not by body weight change Maternal obesity is associated with younger age at obesity onset in US adolescent offspring followed into adulthood Thematic review series: adipocyte biology. Sympathetic and sensory innervation of white adipose tissue The inflammatory syndrome: the role of adipose tissue cytokines in metabolic disorders linked to obesity Using mouse models to dissect the genetics of obesity Energy balance in reversible obesity Effect of diet on adipose tissue and skeletal muscle VLDL receptor and LPL: implications for obesity and hyperlipidemia Renal cell carcinoma following bariatric surgery Pathophysiologic changes of obesity Role of the autonomic nervous system in the development of ventromedial hypothalamic obesity Endurance training partially reverses dietary-induced leptin resistance in rodent skeletal muscle Aspirin as a promoter of ephedrine-induced thermogenesis: potential use in the treatment of obesity The effects of
The Warburg effect: 80 years on The Warburg effect: how does it benefit cancer cells? The Warburg effect in 2012 We need to talk about the Warburg effect The Warburg effect: insights from the past decade The Warburg effect 97 years after its discovery The Warburg effect and its cancer therapeutic implications The Warburg effect: evolving interpretations of an established concept Understanding the Warburg effect: the metabolic requirements of cell proliferation The Warburg effect then and now: from cancer to inflammatory diseases New aspects of the Warburg effect in cancer cell biology The Warburg effect and drug resistance Cancer's molecular sweet tooth and the Warburg effect Warburg effect and its role in tumourigenesis Involvement of the Warburg effect in non‐tumor diseases processes Metabolic changes in cancer: beyond the Warburg effect The Warburg effect and the hallmarks of cancer Warburg effect or reverse Warburg effect? A review of cancer metabolism The Warburg effect: molecular aspects and therapeutic possibilities Cancer metabolism: the Warburg effect today Warburg effect-a consequence or the cause of carcinogenesis? Warburg effect and redox balance Energy boost: the Warburg effect returns in a new theory of cancer Beyond Warburg effect–dual metabolic nature of cancer cells Warburg effect (s)—a biographical sketch of Otto Warburg and his impacts on tumor metabolism From Warburg effect to Reverse Warburg effect; the new horizons of anti-cancer therapy Post-translational modifications and the Warburg effect Tumour-associated mutant p53 drives the Warburg effect The Warburg effect and mitochondrial stability in cancer cells Cellular life span and the Warburg effect The Warburg effect: essential part of metabolic reprogramming and central contributor to cancer progression Reciprocal regulation of HIF-1α and lincRNA-p21 modulates the Warburg effect How the Warburg effect supports aggressiveness and drug resistance of cancer cells? The Warburg effect in tumor progression: mitochondrial oxidative metabolism as an anti-metastasis mechanism Cancer metabolism and the Warburg effect: the role of HIF-1 and PI3K Oxygen consumption can regulate the growth of tumors, a new perspective on the Warburg effect The Warburg effect revisited—lesson from the Sertoli cell Catabolic efficiency of aerobic glycolysis: the Warburg effect revisited Cancer metabolism in space and time: beyond the Warburg effect Emergence of spatial structure in the tumor microenvironment due to the Warburg effect AMPK is a negative regulator of the Warburg effect and suppresses tumor growth in vivo Transcriptional regulation of the Warburg effect in cancer by SIX1 Regulation of the Warburg effect in early-passage breast cancer cells Nuclear PKM2 regulates the Warburg effect The warburg effect: why and how do cancer cells activate glycolysis in the presence of oxygen? Rethinking the Warburg effect with Myc micromanaging glutamine metabolism Metabolic pathways of the Warburg effect in health and disease: perspectives of choice, chain or chance Reversing the Warburg effect as a treatment for glioblastoma A critical review of the role of M2PYK in the Warburg effect A DERL3-associated defect in the degradation of SLC2A1 mediates the Warburg effect Genome-scale metabolic modeling elucidates the role of proliferative adaptation in causing the Warburg effect The Warburg effect
The hallmarks of cancer Revisiting the hallmarks of cancer Hallmarks of cancer: the next generation What are the hallmarks of cancer? Hallmarks of cancer: new dimensions The hallmarks of cancer Wnts and the hallmarks of cancer Hallmarks of cancer: of all cancer cells, all the time? Hallmarks of cancer—the new testament Simulating the hallmarks of cancer The emerging hallmarks of cancer metabolism Evolutionary mechanism unifies the hallmarks of cancer Biological hallmarks of cancer Exploiting the hallmarks of cancer: the future conquest of breast cancer Exercise and the hallmarks of cancer The extracellular matrix modulates the hallmarks of cancer The hallmarks of cancer are also the hallmarks of wound healing Ion channels and the hallmarks of cancer MicroRNAs and the hallmarks of cancer NRF2 and the Hallmarks of Cancer Targeting the hallmarks of cancer: towards a rational approach to next-generation cancer therapy Hallmarks of cancer: interactions with the tumor stroma Imaging hallmarks of cancer in living mice Epigenetic plasticity and the hallmarks of cancer Sp1 and the 'hallmarks of cancer' Hallmarks of cancer and hallmarks of aging An update to hallmarks of cancer The hallmarks of cancer metabolism: Still emerging Endoplasmic reticulum stress and the hallmarks of cancer The microbiome and the hallmarks of cancer The systemic hallmarks of cancer Hallmarks of cancer stem cell metabolism Transforming growth factor-β and the hallmarks of cancer Dual role of autophagy in hallmarks of cancer Mitochondria and the hallmarks of cancer Impact of immune cells on the hallmarks of cancer: A literature review Hallmarks of cancer and AU‐rich elements The hallmarks of cancer from a redox perspective The Warburg effect and the hallmarks of cancer Guidelines for the selection of functional assays to evaluate the hallmarks of cancer The hallmarks of cancer: a long non-coding RNA point of view Molecular principles of metastasis: a hallmark of cancer revisited Hallmarks of cancer: The CRISPR generation Emerging concepts linking obesity with the hallmarks of cancer Lipid mechanisms in hallmarks of cancer Revisiting the hallmarks of cancer: The role of hyaluronan Autophagy and hallmarks of cancer Telomerase: central regulator of all of the hallmarks of cancer The impact of cancer-associated fibroblasts on major hallmarks of pancreatic cancer Heparanase and the hallmarks of cancer The aging of the 2000 and 2011 Hallmarks of Cancer reviews: a critique Effects of animal venoms and toxins on hallmarks of cancer Epigenetic mechanisms and the hallmarks of cancer: An intimate affair The hallmarks of cancer as ecologically driven phenotypes microRNAs in breast cancer: regulatory roles governing the hallmarks of cancer Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability Cancer secretomes and their place in supplementing other hallmarks of cancer Targeting hallmarks of cancer to enhance radiosensitivity in gastrointestinal cancers From the modeling of the immune hallmarks of cancer to a black swan in biology Biological functions of the genes in the mammaprint breast cancer profile reflect the hallmarks of cancer PPAR beta/delta and the hallmarks of cancer Mechanisms of cancer cell dormancy—another hallmark of cancer? Genomic instability—an evolving hallmark
Nasal Colivelin treatment ameliorates memory impairment related to Alzheimer's disease Arctigenin effectively ameliorates memory impairment in Alzheimer's disease model mice targeting both β-amyloid production and clearance Lactobacillus pentosus var. plantarum C29 ameliorates memory impairment and inflammaging in a D-galactose-induced accelerated aging mouse model Tanshinone I enhances learning and memory, and ameliorates memory impairment in mice via the extracellular signal‐regulated kinase signalling pathway Gami-Chunghyuldan ameliorates memory impairment and neurodegeneration induced by intrahippocampal Aβ1–42 oligomer injection Angelica polysaccharide ameliorates memory impairment in Alzheimer's disease rat through activating BDNF/TrkB/CREB pathway Dihydromyricetin ameliorates memory impairment induced by acute sleep deprivation Ferulic acid ameliorates memory impairment in d-galactose-induced aging mouse model Chronic ghrelin administration restores hippocampal long‐term potentiation and ameliorates memory impairment in rat model of Alzheimer's disease Dexmedetomidine ameliorates memory impairment in sleep-deprived mice Guarana (Paullinia cupana) ameliorates memory impairment and modulates acetylcholinesterase activity in Poloxamer-407-induced hyperlipidemia in rat … Berberine exerts an anticonvulsant effect and ameliorates memory impairment and oxidative stress in a pilocarpine-induced epilepsy model in the rat Treadmill exercise ameliorates memory impairment through ERK-Akt-CREB-BDNF signaling pathway in cerebral ischemia gerbils Simvastatin ameliorates memory impairment and neurotoxicity in streptozotocin-induced diabetic mice Anticonvulsant effect of piperine ameliorates memory impairment, inflammation and oxidative stress in a rat model of pilocarpine-induced epilepsy Xanthohumol ameliorates memory impairment and reduces the deposition of β-amyloid in APP/PS1 mice via regulating the mTOR/LC3II and Bax/Bcl-2 signalling … Qingxin kaiqiao fang ameliorates memory impairment and inhibits apoptosis in APP/PS1 double transgenic mice through the MAPK pathway (−)-Epigallocatechin-3-gallate ameliorates memory impairment and rescues the abnormal synaptic protein levels in the frontal cortex and hippocampus in a mouse … GJ-4 ameliorates memory impairment in focal cerebral ischemia/reperfusion of rats via inhibiting JAK2/STAT1-mediated neuroinflammation Deferiprone ameliorates memory impairment in Scopolamine-treated rats: The impact of its iron-chelating effect on β-amyloid disposition The phosphodiesterase type-5 inhibitor, tadalafil, improves depressive symptoms, ameliorates memory impairment, as well as suppresses apoptosis and enhances … 2,2′,4′‐Trihydroxychalcone from Glycyrrhiza glabra as a new specific BACE1 inhibitor efficiently ameliorates memory impairment in mice Phytoestrogen α-zearalanol ameliorates memory impairment and neuronal DNA oxidation in ovariectomized mice Oxymatrine ameliorates memory impairment in diabetic rats by regulating oxidative stress and apoptosis: involvement of NOX2/NOX4 2-Pentadecyl-2-oxazoline ameliorates memory impairment and depression-like behaviour in neuropathic mice: possible role of adrenergic alpha2-and H3 … Danggui-Jakyak-San ameliorates memory impairment and increase neurogenesis induced by transient forebrain ischemia in mice 17-AAG post-treatment ameliorates memory impairment and hippocampal CA1 neuronal autophagic death induced by transient global cerebral ischemia Cotinine ameliorates memory and learning impairment in senescent mice The novel nootropic compound DM232 (UNIFIRAM) ameliorates memory impairment in mice and rats Kisspeptin-13 ameliorates memory impairment induced by streptozotocin in male rats via cholinergic system Sodium valproate ameliorates memory impairment and reduces the elevated levels of apoptotic caspases in the hippocampus of diabetic mice Preischemic treadmill exercise ameliorates memory impairment and microvasculature damage in rat model of chronic cerebral hypoperfusion A humanin derivative reduces amyloid beta accumulation and ameliorates memory deficit in triple transgenic mice Combination of proanthocyanidins extracted from lotus seedpod and l-cysteine ameliorates memory impairment
The GLP-1 agonist, liraglutide, as a pharmacotherapy for obesity GLP-1 agonist to treat obesity and prevent Cardiovascular Disease: what have we achieved so far? The GLP-1 agonist exendin-4 reduces food intake in nonhuman primates through changes in meal size Effects of the GLP‐1 agonist Exendin‐4 on intravenous ethanol self‐administration in mice GLP-1 agonist therapy for advanced heart failure with reduced ejection fraction: design and rationale for the functional impact of GLP-1 for heart failure treatment study Effects of the novel long-acting GLP-1 agonist, albiglutide, on cardiac function, cardiac metabolism, and exercise capacity in patients with chronic heart failure and … GLP-1 agonist treatment: implications for diabetic retinopathy screening The GLP-1 agonist, liraglutide, ameliorates inflammation through the activation of the PKA/CREB pathway in a rat model of knee osteoarthritis … of pentylenetetrazole-induced kindling and behavioral comorbidities in mice by levetiracetam combined with the GLP-1 agonist liraglutide: Involvement of … Antipsychotic-like effect of GLP-1 agonist liraglutide but not DPP-IV inhibitor sitagliptin in mouse model for psychosis Sustained release GLP-1 Agonist PT320 delays disease progression in a mouse model of Parkinson's disease Efficacy of GLP-1 agonist therapy in autosomal dominant WFS1-related disorder: a case report SGLT-2 inhibitor therapy added to GLP-1 agonist therapy in the management of T2DM Proof of concept: Effect of GLP-1 agonist on food hedonic responses and taste sensitivity in poor controlled type 2 diabetic patients Peptide oligomerization memory effects and their impact on the physical stability of the GLP-1 agonist liraglutide Exenatide (a GLP-1 agonist) expresses anti-inflammatory properties in cultured human monocytes/macrophages in a protein kinase A and B/Akt manner Combination of omeprazole with GLP-1 agonist therapy improves insulin sensitivity and antioxidant activity in liver in type 1 diabetic mice Exenatide (a GLP-1 agonist) improves the antioxidative potential of in vitro cultured human monocytes/macrophages Lixisenatide: a new daily GLP-1 agonist for type 2 diabetes management Neurochemical modulation involved in the beneficial effect of liraglutide, GLP-1 agonist on PTZ kindling epilepsy-induced comorbidities in mice Dulaglutide (Trulicity): the third once-weekly GLP-1 agonist Glucose variability in a 26-week randomized comparison of mealtime treatment with rapid-acting insulin versus GLP-1 agonist in participants with type 2 diabetes at … The evolving world of GLP-1 agonist therapies for type 2 diabetes (Val8)GLP‐1‐Glu‐PAL: a GLP‐1 Agonist That Improves Hippocampal Neurogenesis, Glucose Homeostasis, and β‐Cell Function in High‐Fat‐Fed Mice GLP-1 agonist-based therapies: an emerging new class of antidiabetic drug with potential cardioprotective effects Addition of SGLT2 inhibitor to GLP‐1 agonist therapy in people with type 2 diabetes and suboptimal glycaemic control GLP-1 agonist Liraglutide prevents MK‑801–induced schizophrenia‑like behaviors and BDNF, CREB, p-CREB, Trk-B expressions in the hippocampus and prefrontal … Crystal structure of the GLP-1 receptor bound to a peptide agonist Sex-dependent divergence in the effects of GLP-1 agonist exendin-4 on alcohol reinforcement and reinstatement in C57BL/6J mice A new glucagon and GLP-1 co-agonist eliminates obesity in rodents Effects of GLP-1 agonist exenatide on cardiac diastolic function and vascular endothelial function in diabetic patients Rybelsus: an oral formulation of the GLP‐1 agonist semaglutide Anticonvulsant effect of liraglutide, GLP-1 agonist by averting a