SEVEN SAGES

INTERSTELLAR BLEND SEVEN SAGES

What is it??

Imagine your brain and body like a light and bright or pin ball machine with all these different activation points that light up when stimulated or turned on, got it visualized? Good, these are your receptors. Now then we want to activate and light up all of them but not all at once AND to retain the novel experiential effect, the “newness” of each we only want to light it up once a week so it’s always special and appreciated and doesn’t get played out or worn out. This is the idea behind INTERSTELLAR BLEND SEVEN SAGES, almost 180 of the most powerful longevity promoting, cognitive enhancing, mood elevating, energy inducing, kick ass, feel incredible all day long ingredients on the planet IN ONE but strategically spaced out to make tolerance and burn out impossible.

7 totally different formulas for each of the 7 different days of your week—because every day is an ADVENTURE!!!

Click on ingredients to learn about the benefits of each:

Aframomum melegueta

1. Effects of Aframomum melegueta and Piper guineense on sexual behaviour of male rats
2. Gastric and duodenal antiulcer and cytoprotective effects of Aframomum melegueta in rats
3. Hepatoprotective effect of aqueous extract of Aframomum melegueta on ethanol-induced toxicity in rats.
4. Ameliorative potential of Aframomum melegueta extract in cadmium-induced hepatic damage and oxidative stress in male Wistar rats.

Agaricus blazei

1. Antitumor effect of a peptide-glucan preparation extracted from Agaricus blazei in a double-grafted tumor system in mice
2. Effect of hot water extract from Agaricus blazei Murill on antibody-producing cells in mice
3. Isolation of an antitumor compound from Agaricus blazei Murill and its mechanism of action
4. The Protective Effects of Polysaccharides from Agaricus blazei Murill Against Cadmium-Induced Oxidant Stress and Inflammatory Damage in Chicken Livers

Agaricus subrufescens

1. Anti-cancer and tumor suppressive activity
2. Anti-genotoxicity activities
3. Immune System Enhancer (anti-bacterial and anti-viral)
4. Cytokine induction
5. Lymphocyte activation
6. Antimicrobial activity
7. Anti-allergy effect
8. Normalizes liver function

Agmatine

1. Agmatine effects on mitochondrial membrane potential andNF‐κB activation protect against rotenone‐induced cell damage in human neuronal
2. Agmatine, a bioactive metabolite of arginine. Production, degradation, and functional effects in the kidney of the rat.Agmatine produces antidepressant-like effects in two models of depression in mice
3. Top 3 Agmatine Sulphate Benefits For Cognition, Mood, and Fitness
4. Agmatine rescues autistic behaviors in the valproic acid-induced animal model of autism
5. Decreased plasma agmatine levels in autistic subjects
6. Energy metabolism and autism: the ameliorative potential of carnosine and agmatine
7. Agmatine prevents LPS-induced spatial memory impairment and hippocampal apoptosis
8. Different behavior of agmatine in liver mitochondria: Inducer of oxidative stress or scavenger of reactive oxygen species?

Ajuga Turkestanica

1. Hypoglycemic / Anti-diabetic effects
2. Metabolism enhancing effects
3. Antiproliferative, antimicrobial and antioxidant activities
4. Contains ecdysterone and turkesterone which both have very high anabolic activities
5. Increases Notch and Wnt signaling which may provide a protective effect and maintain the integrity of aged skeletal muscle.
6. Prevent age related muscle wasting (Sarcopenia)
7. Immunomodulating and antistress activity
8. Increased protein synthesis
9. Understanding adaptogenic activity: specificity of the pharmacological action of adaptogens and other phytochemicals

Albizzia

1. Anti-tumor effects
2. Antioxidant activity
3. Anti-depressant like effects
4. Invigorate the circulation of blood
5. Anxiolytic (reduces anxiety)
6. Anti-inflammatory
7. Anti-angiogenic effects
8. The aqueous extract of Albizia adianthifolia leaves attenuates 6-hydroxydopamine-induced anxiety, depression and oxidative stress in rat amygdala

Alpha GPC

1. The effects of alpha-glycerylphosphorylcholine, caffeine or placebo on markers of mood, cognitive function, power, speed, and agility
2. Effects of L‐alpha‐glycerylphosphorylcholine on the EEG power spectrum in the rat
3. Effect of a new cognition enhancer, alpha-glycerylphosphorylcholine, on scopolamine-induced amnesia and brain acetylcholine
4. Neuroprotective effect of treatment with galantamine and choline alphoscerate on brain microanatomy in spontaneously hypertensive rats
5. Cognitive improvement in mild to moderate Alzheimer’s dementia after treatment with the acetylcholine precursor choline alfoscerate

American ginseng

1. American ginseng (Panax quinquefolius L) reduces postprandial glycemia in nondiabetic subjects and subjects with type 2 diabetes mellitus
2. Protective effect of steamed American ginseng (Panax quinquefolius L.) on V79-4 cells induced by oxidative stress
3. Antioxidant properties of a North American ginseng extract
4. Antioxidant effects of American ginseng berry extract in cardiomyocytes exposed to acute oxidant stress

Ampalex

1. Antidepressant activity of memory-enhancing drugs in the reduction of submissive behavior model
2. Novel antipsychotics in schizophrenia
3. The anticonvulsants lamotrigine, riluzole, and valproate differentially regulate AMPA receptor membrane localization: relationship to clinical effects in mood disorders
4. AMPA receptors in the therapeutic management of depression
5. Antidepressant activity of memory-enhancing d r u g s in the reduction of submissive behavior model.
6. Facilitative Effects of the Ampakine CX516 on Short-Term Memory in Rats: Enhancement of Delayed-Nonmatch-to-Sample Performance

Aniracetam

1. Effects of the novel compound aniracetam (Ro 13-5057) upon impaired learning and memory in rodents
2. Allosteric potentiation of quisqualate receptors by a nootropic drug aniracetam.
3. Selective effects of aniracetam across receptor types and forms of synaptic facilitation in hippocampus
4. Aniracetam: its novel therapeutic potential in cerebral dysfunctional disorders based on recent pharmacological discoveries

Arctigenin

1. Arctigenin Inhibits Adipogenesis by Inducing AMPK Activation and Reduces Weight Gain in High‐Fat Diet‐Induced Obese Mice
2. Arctigenin protects cultured cortical neurons from glutamate‐induced neurodegeneration by binding to kainate receptor
3. Tumor specific cytotoxicity of arctigenin isolated from herbal plant Arctium lappa L.
4. Arctigenin reduces neuronal responses in the somatosensory cortex via the inhibition of non-NMDA glutamate receptors
5. Arctigenin Protects against Lipopolysaccharide-Induced Pulmonary Oxidative Stress and Inflammation in a Mouse Model via Suppression of MAPK, HO-1, and iNOS Signaling

Ariocarpus fissuratus

1. Ariocarpus,- Cacti for the young (or Young at Heart)
2. Ariocarpus fissuratus
3. LOPHOPHORA: Flowering Ariocarpus fissuratus

Artichoke leaf

1. Artichoke leaf extract—recent findings reflecting effects on lipid metabolism, liver and gastrointestinal tracts
2. Artichoke leaf extract reduces symptoms of irritable bowel syndrome and improves quality of life in otherwise healthy volunteers suffering from concomitant dyspepsia
3. Artichoke leaf extract (Cynara scolymus) reduces plasma cholesterol in otherwise healthy hypercholesterolemic adults: a randomized, double blind placebo controlled
4. An open-label pilot study of a formulation containing the anti-inflammatory flavonoid luteolin and its effects on behavior in children with autism spectrum disorders
5. Brain “fog,” inflammation and obesity: key aspects of neuropsychiatric disorders improved by luteolin
6. Activity of artichoke leaf extract on reactive oxygen species in human leukocytes
7. Luteolin-rich artichoke extract protects low density lipoprotein from oxidation In vitro
8. Choleretic activity and biliary elimination of lipids and bile acids induced by an artichoke leaf extract in rats
9. Effect of Artichoke Leaf Extract on Hepatic and Cardiac Oxidative Stress in Rats Fed on High Cholesterol Diet

Ashwaghanda

1. Antistressor effects
2. Antioxidant effects
3. Anti-inflammatory Properties
4. Antitumor Properties
5. Immunomodulatory Properties
6. Hemopoetic effects
7. Rejuvenating effects
8. Cognition-enhancing and memory-improving effects
9. Stimulates thyroidal activity and promotes hepatic antioxidant activity
10. Neuroprotective effects
11. Cardioprotective effects
12. Anxiolytic-antidepressant activity
13. Reverses Alzheimer’s pathology by enhancing low-density lipoprotein receptor-related protein in liver
14. Recent updates in the treatment of neurodegenerative disorders using natural compounds
15. Research Article Withania somnifera Ameliorates Sodium Valproate Induced Austism in BALB/c Mice: Behavioral and Biochemical Evidences
16. Withania somnifera (ASHWAGANDHA) ATTENUATES ANTIOXIDANT DEFENSE IN AGED SPINAL CORD AND INHIBITS COPPER INDUCED LIPID PEROXIDATION AND PROTEIN OXIDATIVE MODIFICATIONS

Astragalus

1. Anti-tumor effects
2. Immunomodulating and immunorestorative effects
3. Beneficial effects on insulin resistance and hyperglycemia
4. Cardioprotection
5. Significantly induces nitric oxide (NO) production
6. Lowers blood pressure
7. Antioxidant and anti-diabetes effects
8. Increased motility of sperm
9. Renal protective effect
10. AMPK Activator
11. Anti-aging effect
12. mTOR inhibiting effect
13. Astragalus polysaccharide ameliorates ionizing radiation-induced oxidative stress in mice

Atractylodes

1. Insulin mimetic activity / AMPK activation
2. Anti-cancer effect–cell cycle arrest and apoptosis via inhibition of PI3K/Akt/mTOR signaling pathway
3. Anti-diabetic effect
4. Anti-inflammatory activity
5. Neuroprotective activity
6. Antioxidant Properties of Flavone C‐Glycosides from Atractylodes japonica Leaves in Human Low‐density Lipoprotein Oxidation

Avena sativa

1. Effect of Avena sativa on cigarette smoking
2. In vitro inhibitory effect on pancreatic lipase activity of subfractions from ethanol extracts of fermented oats (Avena sativa L.) and synergistic effect of three phenolic
3. Avena sativa (Oat), A Potential Neutraceutical and Therapeutic Agent: An Overview
4. Oxidative stress in interactions between Avena sativa L. and Drechslera spp.

Bacopa monnieri

1. Positive effects on learning and memory.
2. Free radical scavenging capacity and protective effect
3. Significant antidepressant activity in learned helplessness models of depression
4. Potent adaptogenic activity
5. Antioxidant activity
6. Anxiolytic (anti-anxiety) activity
7. Anti-inflammatory activity
8. Prevents from aluminum neurotoxicity
9. Neuroprotective effects in Alzheimer’s and dementia
10. Anti-Parkinson’s effects
11. Neuroprotective efficacy of Bacopa monnieri against rotenone induced oxidative stress and neurotoxicity in Drosophila melanogaster

Ban Xia

1. Efficacy of modified ban xia xie xin decoction on functional dyspepsia of cold and heat in complexity syndrome: a randomized controlled trial
2. Antiemetic effect of Xiao-Ban-Xia-Tang, a Chinese medicinal herb recipe, on cisplatin-induced acute and delayed emesis in minks
3. Effect of the Aqueous Extract of Xiao-Ban-Xia-Tang on Gastric Emptying in Mice

Banaba leaf

1. Antiobesity activity of extracts from Lagerstroemia speciosa L. leaves on female KK-Ay mice
2. Antidiabetes and anti-obesity activity of Lagerstroemia speciosa
3. Hypoglycemic activity of Lagerstroemia speciosa L. extract on streptozotocin-induced diabetic rat: Underlying mechanism of action

Bee pollen

1. Anti-allergic effect of bee pollen phenolic extract and myricetin in ovalbumin-sensitized mice
2. Antioxidant effects of flavonoid from Croatian Cystus incanus L. rich bee pollen
3. Effect of carbaryl on some biochemical changes in rats: the ameliorative effect of bee pollen
4. Alleviating exercise-induced muscular stress using neat and processed bee pollen: oxidative markers, mitochondrial enzymes, and myostatin expression in rats

Berberine

1. Effects and action mechanisms of berberine and Rhizoma coptidis on gut microbes and obesity in high-fat diet-fed C57BL/6J mice
2. Structural changes of gut microbiota during berberine-mediated prevention of obesity and insulin resistance in high-fat diet-fed rats
3. Berberine improves lipid dysregulation in obesity by controlling central and peripheral AMPK activity
4. Berberine ameliorates renal injury in streptozotocin-induced diabetic rats by suppression of both oxidative stress and aldose reductase

Bitter melon

1. Effects of Momordica charantia on insulin resistance and visceral obesity in mice on high-fat diet
2. Antihyperglycemic effects of three extracts from Momordica charantia
3. The effect of Momordica charantia and Mucuna pruriens in experimental diabetes and their effect on key metabolic enzymes involved in carbohydrate metabolism
4. Momordica charantia (bitter melon) attenuates high-fat diet-associated oxidative stress and neuroinflammation

Black tea

1. Anti-obesity effects of epigallocatechin-3-gallate, orange peel extract, black tea extract, caffeine and their combinations in a mouse model
2. Antiobesity Effects of Chinese Black Tea (Pu‐erh Tea) Extract and Gallic Acid
3. Antihypercholesterolemic effect of Chinese black tea extract in human subjects with borderline hypercholesterolemia
4. Effects of black tea consumption on plasma catechins and markers of oxidative stress and inflammation in patients with coronary artery disease

Capsaicin

1. Obesity and thermogenesis related to the consumption of caffeine, ephedrine, capsaicin, and green tea
2. Effects of capsaicin-containing yellow curry sauce on sympathetic nervous system activity and diet-induced thermogenesis in lean and obese young women
3. Dietary capsaicin reduces obesity‐induced insulin resistance and hepatic steatosis in obese mice fed a high‐fat diet
4. Induction of Apoptosis in Leukemic Cells by Homovanillic Acid Derivative, Capsaicin, through Oxidative Stress

Catuaba bark

1. Anti-viral effects
2. Antioxidant activities
3. Increases vitality, combats nervous asthenia
4. Potent protecting effects against hydroperoxide-induced cytotoxicity
5. Cytoprotective effects on Rotenone-induced apoptosis in human neuroblastomas SH-SY5Y cells.
6. Antidepressant-like effects: evidence for dopaminergic-mediated mechanisms
7. Neuroprotective effects
8. Antinociceptive effects (Reduced sensitivity to pain)
9. Increases hippocampal cell proliferation
10. Memory enhancing effects
11. Trichilia catigua (Catuaba) bark extract exerts neuroprotection against oxidative stress induced by different neurotoxic agents in rat hippocampal slices

CDP choline

1. Effects of CDP-choline treatment on neurobehavioral deficits after TBI and on hippocampal and neocortical acetlycholine release
2. Citicoline (CDP-choline): mechanisms of action and effects in ischemic brain injury
3. Effects of CDP-choline on the recovery of patients with head injury
4. Choline attenuates immune inflammation and suppresses oxidative stress in patients with asthma

Ceylon cinnamon

1. Lowered blood glucose, reduces food intake, and reduces atherogenic LDL cholesterol.
2. Accelerated wound healing effects
3. Antimicrobial activity
4. Antioxidant activity and scavenging effects
5. Ameliorative Effect upon Early Stage Diabetic Nephropathy
6. Anti-diabetic effect via i) upregulation of mitochondrial UCP-1, and ii) enhanced translocation of GLUT4 in the muscle and adipose tissues.
7. AMPK activator

Chaga

1. Antioxidant effects
2. Immuno-stimulating anti-cancer effects
3. Anti-inflammatory and anti-nociceptive effects
4. Antihyperglycemic and antilipidperoxidative effects
5. Antimitotic (capable of arresting the process of cell division) activity
6. Antimutagenic (protects DNA) effects
7. Improved insulin sensitivity and reduced adiposity
8. Prevention of hydrogen peroxide-induced oxidative stress in PC12 cells by 3,4-dihydroxybenzalacetone isolated from Chaga (Inonotus obliquus (persoon) Pilat)

Cinnamomum parthenoxylon

1. Significant changes in body weight loss and fasting blood glucose levels
2. Antileukemic activity
3. Hepatoprotective and antioxidant activity
4. Cinnamtannin D-1 Protects Pancreatic β-Cells from Palmitic Acid-Induced Apoptosis by Attenuating Oxidative Stress

Cissus Quadrangularis

1. The effect of Cissus quadrangularis (CQR-300) and a Cissus formulation (CORE) on obesity and obesity-induced oxidative stress
2. The use of a Cissus quadrangularis/Irvingia gabonensis combination in the management of weight loss: a double-blind placebo-controlled study
3. The use of a Cissus quadrangularis formulation in the management of weight loss and metabolic syndrome
4. Gastroprotective action of Cissus quadrangularis extract against NSAID induced gastric ulcer: Role of proinflammatory cytokines and oxidative damage

Cistanche

1. Anti-hyperglycemic and hypolipidemic effects
2. Telomerase activity and anti-aging effects
3. Antidepressant and Cognitive Improvement Activities
4. Protective effects in dopaminergic neurons
5. Hepatoprotective effects
6. Vasorelaxant activity
7. Improved glucose tolerance
8. Neuroprotective, immunomodulatory, anti-oxidative, kidney impotence, laxative, anti-inflammatory, hepatoprotective, anti-bacterial, anti-viral, and anti-tumor effects
9. Tubuloside B from Cistanche salsa Rescues the PC12 Neuronal Cells from 1-Methyl-4-phenylpyridinium Ion-Induced Apoptosis and Oxidative Stress

Citris Aurantium extract

1. Metabolic and physiological effects of ingesting extracts of bitter orange, green tea and guarana at rest and during treadmill walking in overweight males
2. Citrus aurantium and synephrine alkaloids in the treatment of overweight and obesity: an update
3. A review of the human clinical studies involving Citrus aurantium (bitter orange) extract and its primary protoalkaloid p-synephrine
4. Oxidative stress-related lung dysfunction by chromium(VI): alleviation by Citrus aurantium L.

Citruline

1. L-arginine supplementation in patients with mild arterial hypertension and its effect on plasma level of asymmetric dimethylarginine, L-citruline, L-arginine
2. Effects of L-canavanine, L-arginine, L-ornitine, L-citruline and L-canaline on pentylenetetrazole seizures
3. Effects of citrulline supplementation on fatigue and exercise performance in mice
4. Oxidative stress parameters and anti-apoptotic response to hydroxyl radicals in fish erythrocytes: Protective effects of glutamine, alanine, citrulline and proline

Cnidium seed

1. Anti allergenic effects
2. Anti-tumor effects
3. Antiproliferative effects
4. Glucocorticoids-induced osteoporosis preventive effects
5. Anti-inflammatory effects
6. Neuroprotective effects
7. AMPK activator
8. Antidiabetic effects
9. mTOR inhibitor
10. Antifibrotic activity
11. Protective effect of the extracts from Cnidium officinale against oxidative damage induced by hydrogen peroxide via antioxidant effect

Codonopsis

1. Anti-inflammatory activity
2. Invigorating energy,activating blood flow,resolving blood stasis and anti-aging actions
3. Protective effects against alcoholic fatty liver through AMPK activation
4. Ameliorating effects on memory and learning deficits
5. Anti-tumor effects
6. Neuroprotective effects
7. Cognitive enhancing effects
8. Anti-obesity effects
9. Methanol Extract of Codonopsis pilosula Inhibits Inducible Nitric Oxide Synthase and Protein Oxidation in Lipopolysaccharide-Stimulated Raw Cells

Coluracetam

1. Coluracetam – Nootropic Review of Effects, Dosage, and More
2. Coluracetam: Review of the Benefits
3. Coluracetam – A Powerful New Racetam Analog

Coptis chinemsis

1. Coptis chinensis alkaloids exert anti-adipogenic activity on 3T3-L1 adipocytes by downregulating C/EBP-α and PPAR-γ
2. Anti-diabetic effect of Coptis Chinensis polysaccharide in high-fat diet with STZ-induced diabetic mice
3. Anti-Diabetic Effects of a Coptis chinensis Containing New Traditional Chinese Medicine Formula in Type 2 Diabetic Rats
4. Coptis chinensis Franch. exhibits neuroprotective properties against oxidative stress in human neuroblastoma cells

Cordyceps

1. Antiangiogenetic properties
2. Scavenging of free radicals and anti-cancer activity
3. Has been shown to significantly stimulate testosterone production
4. Strong anti-tumor activity
5. May be used as an immunopotentiating agent in treating cancer and immunodeficient patients
6. Anti-diabetic effects
7. Increased hepatic blood flow
8. Anti-aging effects
9. Protects cells against hydrogen peroxide-induced injury
10. Anti-fatigue effects
11. Anti-depressant like effects
12. Increased whole body insulin sensitivity
13. Neuroprotective effects
14. AMPK Activation: induces fatigue recovery via activating AMPK
15. mTOR inhibition
16. Polysaccharides from Cordyceps sinensis mycelium ameliorate exhaustive swimming exercise-induced oxidative stress

Cornus fruit

1. Plays an important role against diabetic pathogenesis, i.e., reducing glucose toxicities, up-regulating renal function, and consequently ameliorating glycation-associated renal damage
2. AMPK Activation with Potent Ant-Obesity effects
3. Antineoplastic, antioxidative, and antidiabetic effects
4. Regulation of muscle protein synthesis and neuroprotection
5. Apoptotic action of ursolic acid isolated from Corni fructus in human prostate cancer cells
6. Combined with red ginseng improves facial wrinkles, a clinical sign of photoaging; evidence of increased collagen synthesis in the dermis.
7. Promising agent against hypertriglyceridaemia without hepatic side-effects.
8. Hydrogen peroxide scavenging activity
9. May protect against CVD by regulating blood pressure, cholesterol levels, and expression of proteins related to lipid metabolism
10. Protective Effects of Corni Fructus against Advanced Glycation Endproducts and Radical Scavenging
11. EVALUATION OF THE FAT TISSUE OXIDATIVE STRESS PARAMETERS IN WISTAR RATS IN FRUCTOSE AND HIGH-FAT DIETS WITH THE ADDITION OF CORNUS MAS L.AND ARONIAJUICE

Cuscuta seed

1. Hepatoprotective and antioxidant effects
2. Immunostimulating activity
3. Antiosteoporotic activity
4. Anti-aging agent, anti-inflammatory agent, pain reliever and aphrodisiac
5. Antidepressant activity
6. Neuroprotective effects
7. Reversed the reduction of testosterone level and the expression of androgen receptor gene in kidney-yang deficient mice

Cynomorium root

1. Flavan-3-ol contents, anti-oxidative and α-glucosidase inhibitory activities
2. Neuroprotective activity
3. Enhance endurance exercise performance by reducing muscle fatigue
4. Therapeutic effect with perimenopausal depression
5. Has the potential for enhancing hippocampal plasticity and can be used to people who have problems in hippocampal memory
6. May offer a promising prospect in preventing obesity and the associated metabolic syndrome and health consequences
7. Anti-oxidative and anti-fatigue properties
8. Coral physiological adaptations to air exposure: Heat shock and oxidative stress responses in Veretillum cynomorium

Damiana

1. Turnera diffusa Wild (Turneraceae) recovers sexual behavior in sexually exhausted males
2. Pro-sexual effects of Turnera diffusa Wild (Turneraceae) in male rats involves the nitric oxide pathway
3. Effects of a hydroalcoholic extract of Turnera diffusa Willd. ex Schult., Turneraceae, in tests for adaptogenic activity

Dang Gui root

1. Effects of Kampo medicine, Toki-shakuyaku-san (Tang-Kuei-Shao-Yao-San), on choline acetyltransferase activity and norepinephrine contents in brain regions
2. Effect of components of dang-gui-bu-xue decoction on hematopenia
3. A randomized, double-blind, placebo-controlled study of the effect of a Chinese herbal medicine preparation (Dang Gui Buxue Tang) on menopausal symptoms
4. DPPH radical scavenger activity and antioxidant effects of Cham-Dang-Gui (Angelica gigas)
5. Myocardial protection against ischaemia‐ reperfusion injury by a Polygonum multiflorum extract supplemented ‘Dang‐Gui decoction for enriching blood
6. Dang‐Gui Buxue Tang produces a more potent cardioprotective effect than its component herb extracts and enhances glutathione status in rat heart mitochondria
7. Antioxidant and antiplatelet effects of dang-gui-shao-yao-san on human blood cells
8. The effect of dang-gui (Angelica sinensis) and its ingredient ferulic acid on rat platelet aggregation and release of 5-HT
9. Dang-Gui Buxue Tang Protects against Oxidant Injury by Enhancing Cellular Glutathione in H9c2 Cells: Role of Glutathione Synthesis and Regeneration