When it comes to weight loss chlorogenic acid in the green coffee affects how the body utilizes the sugar and metabolism.
GCBE has a potential anti-obesity effect with lowering body fat accumulation by regulating adipogenesis and lipid metabolism-related genes and proteins in WAT and liver.
Blood Sugar and Insulin Levels -GCB can normalize blood sugar levels significantly which then can lower the risk of type 2 diabetes. A study published in 2014 by Evidence-Based Complementary and Alternative Medicine (eCAM) showed evidence where decaf green coffee beans appeared to reverse the high fast diet and induced fat accumulation, insulin resistance by regulating the genes which were involved in the adipogenesis.
In conclusion, the present study shows that green coffee bean extract significantly reduces visceral fat-pad accumulation and improves insulin resistance in mice fed the HFD at a minimum effective dose of 0.3% supplementation. We suggest that 5-CQA and other polyphenols in green coffee bean extract may bring an additive effect in decreasing body weight gain and increasing insulin sensitivity. These beneficial effects are possibly due to the downregulation of genes associated with adipogenesis and inflammation in the WAT of mice. Taken as a whole, decaffeinated green coffee bean extract may be used as a therapeutic agent that prevents obesity and metabolic syndrome.
Lower Blood Pressure - Supporting evidence shows that chlorogenic acid contains hypo-glycemic agents and can affect the lipid metabolism which then results in a decrease in cholesterol and triglyceride concentrations within the blood. In a study rats were administered GCBE for three weeks. It was discovered that the extracted supported many markers. In the report they stated "Fasting plasma cholesterol and triacylglycerols concentrations significantly decreased by 44% and 58% respectively, as did in liver triacylglycerols concentrations (24%)."
As little as 32 mg (which elevated plasma caffeine concentration to less than 1 μg/ml), typical of the dose found in a single serving of a cola beverage, and less than that found in a single cup of coffee or a single dose of over-the-counter drugs, significantly improved auditory vigilance and visual reaction time. All other caffeine doses administered also significantly improved performance on these tests. No adverse behavioral effects, such as increased anxiety or impaired motor performance, were noted even at the highest dose administered.
Chemoprotective and Antigenotoxic - Here we investigated components of a German wheat bread supplemented with green coffee antioxidants (GC) to assess basic biological activities in human cells in culture. We analyzed chlorogenic acid (ChA) in the bread and determined antioxidative activities. The supplementation of bread with GC improves the chemoprotective property of normal bread under these in vitro cell culture conditions. Supplementation also increases ChA content and antioxidative capacity. The treatment of the cells with supplemented bread increases resistance of colon and liver cells against H2O2, a source of oxidative stress.