• SHOP
  • SAMPLES
  • COMBOS
  • TESTIMONIALS
  • CART
  • INGREDIENTS
    • 2-DEOXY-D-GLUCOSE (2DG)
    • ACACIA CYANOPHYLLA FLOWER
    • ACORI GRAMINEI RHIZOMA
    • AEGLE MARMELOS CORREA
    • AGARICUS BLAZEI
    • AGED GARLIC EXTRACT
    • AFRAMOMUM MELEGUETA
    • ALOE ARBORESCENS
    • ALBIZIA
    • ALPINIA OFFICINARUM
    • ALTERNANTHERA SESSILIS
    • AMERICAN GINSENG
    • AMYGDALIN
    • ANACYCLUS PYRETHRUM
    • ANGELICA ARCHANGELICA
    • ANGELICA SINENSIS
    • ANTRODIA
    • ARTICHOKE LEAF
    • ARTOCARPIN
    • AJUGA TURKESTANICA
    • ASHWAGANDHA
    • ASPALATHIN
    • ASTRAGALUS COMPLANATUS
    • AVENA SATIVA
    • BACOPA MONNIERI
    • Bavachin Psoralea Corylifolia
    • BEE POLLEN
    • BETULINIC ACID
    • BOSWELLIC ACID (BOSWELLIA CARTERI)
    • BREVILIN A
    • CAMPESTEROL
    • CAPSAICIN
    • CARCININE
    • CASTICIN
    • CHRYSIN
    • CIANIDANOL
    • CINNAMOMUM ZEYLANICUM
    • CITRULLUS COLOCYNTHIS
    • CITRUS RETICULATA PEEL
    • CODONOPSIS
    • CONJUGATED LINOLEIC ACID
    • COSTUNOLIDE
    • CYANIDIN
    • CUCURBITACIN D
    • DAIDZEIN
    • DECURSIN
    • DELPHINIDIN
    • DIGITALIS PURPREA (DIGOXIN)
    • DIOSMIN
    • Ecklonia Cava
    • Ellagic Acid
    • EMBELIN
    • ERIODICTYOL
    • GALLIC ACID
    • GLYCITEIN
    • GLYCYRRHIZIN
    • HYPERFORIN
    • ICARIIN
    • ISORHAMNETIN
    • ISOORIENTIN
    • ISOVITEXIN
    • JACEOSIDIN
    • KAEMPFEROL
    • KIGELIA AFRICANA
    • KURARINONE
    • LEMON BALM
    • LICORICIDIN
    • LIPOIC ACID
    • LUPEOL
    • MAGNOLOL
    • MENAQUINONE 4
    • MULBERRY LEAF
    • NARINGENIN
    • NOBILETIN
    • OLEACEIN
    • OLEANOLIC ACID
    • OLIVE OIL
    • ORIDONIN
    • PARTHENOLIDE
    • PHLOROGLUCINOL
    • PHLORIZIN
    • PICEATANNOL
    • PRISTIMERIN
    • PROANTHOCYANIDINS
    • PROCYANIDIN B3
    • PSEUDOLARIC ACID B
    • PTEROSTILBENE
    • RUTIN
    • SOLIDAGO VIRGAUREA
    • TANGERETIN
    • TARAXASTEROL
    • TRICHOSTATIN A
    • WEDELOLACTONE
    • WOGONIN
    • YERBA MATE
  • ABOUT
  • SCIENTIFIC STUDIES
    • ADAPTOGENS
    • ADIPOCYTE APOPTOSIS (KILLING FAT CELLS)
    • ADDICTION & THE BRAIN
    • ADDICTION & STRESS
    • ADDICTION WITHDRAWAL
    • ADIPOCYTE DEDIFFERENTIATION (THE REVERSAL OF FAT FORMATION)
    • ADIPOCYTE DIFFERENTIATION
    • ADROPIN
    • ALLERGIES & CYTOKINES
    • ALDOSTERONE & OBESITY/HYPERTENSION
    • ALZHEIMER’S, DEMENTIA, PARKINSON’S
    • ANTI-ACNE EFFECT OF FLAVONOIDS AND POLYPHENOLS
    • ADVANCED GLYCATION END PRODUCTS (AGES)
    • ADDICTION TREATMENT
    • ADDICTION & DOPAMINE
    • AMPK
    • ANTI AGING
    • ANTIAGING EFFECTS OF COFFEE
    • ANTI-AGING EFFECTS OF FLAVONOIDS & POLYPHENOLS
    • ANTI-APOPTOTIC PATHWAYS
    • ANTI ATHEROGENIC
    • ANTI-CANCER EFFECTS OF FLAVONOIDS & POLYPHENOLS
    • ANTI CARIOGENIC (Protecting From Tooth Decay)
    • ANTI COVID-19 EFFECTS OF MEDICINAL PLANTS, FLAVONOIDS & POLYPHENOLS
    • ANTI GLYCATIVE
    • ANTI GLYCATION AGENTS
    • ANTI-INFLAMMATORY EFFECTS OF FLAVONOIDS & POLYPHENOLS
    • ANTI-VIRAL EFFECTS OF FLAVONOIDS & POLYPHENOLS
    • ANTI WRINKLE AGENTS
    • ANXIOGENIC
    • ANXIOLYTIC
    • APOPTOSIS
    • APOPTOSIS IN 3T3-L1
    • AUTOPHAGY
    • BCL-2
    • BCL-W
    • BCL-XL
    • BDNF
    • BECLIN-1 & AUTOPHAGY
    • BH3 MIMETICS
    • BIM aka BCL2L11
    • BIOMIMETIC HYDROXYAPATITE
    • BMI-1
    • BPA & OBESITY
    • BRASSINOSTEROIDS
    • CALORIE RESTRICTION
    • CALORIE RESTRICTION & LIFESPAN EXTENSION
    • CARBAMYLATION
    • CARBONYL SCAVENGER
    • CARBONYL STRESS
    • CARDIOPROTECTIVE AGENTS
    • CARDIAC GLYCOSIDES
    • CATALASE
    • CELL CYCLE ARREST
    • CENTENARIANS
    • CDK5
    • CHOLESTEROL EFFLUX
    • COGNITIVE ENHANCEMENT
    • COLD SHOCK PROTEINS
    • COLD-INDUCIBLE RNA-BINDING PROTEIN (CIRBP) & DNA REPAIR
    • CONDITIONED PLACE PREFERENCE
    • CORTICOTROPIN RELEASING FACTOR
    • COSMECEUTICAL
    • CRYOTHERAPY
    • CRYOLIPOLYSIS: FREEZING FAT TO DEATH
    • CYP2E1
    • CYTOKINES IN PAIN, INFLAMMATION & AGING
    • DAF-16
    • DEPERSONALIZATION
    • DIABETES & CANCER
    • DIHYDROTESTOSTERONE (DHT)
    • DNA METHYLATION & AGING
    • DNA REPAIR
    • DNA REPAIR VIA FLAVONOIDS & POLYPHENOLS
    • DRY FASTING AND FLUID RESTRICTION FASTING
    • DYNORPHIN
    • ELLAGITANNINS
    • ENDOCRINE DISRUPTING CHEMICALS
    • ENLARGED HEART AND CARDIOMEGALY
    • EPIGENETIC ALTERATIONS
    • EPIGENETIC MODIFIERS
    • EPINEPHRINE
    • ERGOGENIC AGENTS (INCREASE ATHLETIC PERFORMANCE)
    • EXCITOXICITY & THE BRAIN
    • EXTRACELLULAR MATRIX STIFFENING (10TH HALLMARK OF AGING)
    • EXTRACELLULAR MICROVESICLES
    • EXTENDS LIFESPAN
    • EXTINCTION TRAINING
    • FASTING & THE BRAIN
    • FASTING & CANCER
    • FASTING MIMICKING DIET
    • FEAR EXTINCTION
    • FGF21
    • FLAVONES
    • GABA (γ-AMINOBUTYRIC ACID)
    • GALLOTANNINS
    • GLUCONEOGENESIS
    • GLUCOCORTICOID RECEPTOR ACTIVATION
    • GLUTAMATE & BRAIN
    • GLYCATION
    • GUT BRAIN AXIS
    • GYPENOSIDE
    • KLOTHO
    • K OPIOD RECEPTOR & ADDICTION
    • FASTING, CALORIE RESTRICTION & EXTENDING LIFESPAN
    • FGF21
    • FOXO3
    • FOXO4
    • HALLMARKS OF AGING
    • HAIR GROWTH
    • HAIR REGENERATION
    • HAIR REPIGMENTATION
    • HEPATOPROTECTIVE AGENTS (KEEPING LIVER HEALTHY)
    • HMGB1
    • HORMESIS
    • HPA AXIS
    • HSP70, THE ANTI-AGING PROTEIN
    • HSP90 INHIBITORS
    • HYPERGLYCEMIA
    • HYPERALGESIA
    • HYPERINSULINEMIA
    • HYPOTHALAMIC PITUITARY ADRENAL HPA AXIS
    • HYPOACTIVE SEXUAL DESIRE (WHY PEOPLE HAVE ZERO SEX DRIVE)
    • HYPOCRETIN OREXIN
    • IKK
    • IL-6/STAT3
    • IRISIN
    • ISOFLAVONES
    • IMMUNOSENESCENCE
    • INHIBITION OF ADVANCED GLYCATION END PRODUCTS
    • INCREASE PROTEIN SYNTHESIS
    • INCREASES SPERMATOGENESIS
    • INFECTOBESITY
    • INFLAMMATION & ANXIETY
    • INFLAMMATION & CANCER
    • INFLAMMATION & DEPRESSION
    • INFLAMMATION & OBESITY
    • INFLAMMAGING
    • INHIBITION OF RENAL GLUCOSE REABSORPTION
    • INSULIN & AGING
    • INSULIN & CANCER: HOW INSULIN LITERALLY PROTECTS CANCER CELLS FROM BEING KILLED
    • INSULIN & MTOR
    • INSULIN & OBESITY
    • INSULIN OXIDATIVE STRESS
    • INTERMITTENT FASTING
    • JAK INHIBITION ALLEVIATES SASP
    • JNK ACTIVATION PREVENTS PREMATURE SENESCENCE
    • KETONE BODIES
    • KETOGENIC DIET
    • LACTOBACILLUS REUTERI
    • LACTOFERRIN
    • LEYDIG CELL STEROIDOGENESIS
    • LIFESPAN EXTENSION
    • LIVER REGENERATION
    • LIPOLYTIC AGENTS
    • LIPID DROPLETS
    • LIPOLYSIS (THE DECOMPOSITION OF BODY FAT)
    • LOWERING CHOLESTEROL THRU FASTING, DIET & MEDICINAL PLANTS
    • MATRIX METALLOPROTEINASES (MMPs)
    • MCL-1
    • MDM2 INHIBITION AS SASP INHIBITOR
    • MEDICINAL MUSHROOMS
    • MEDITERRANEAN DIET
    • METABOLIC REPROGRAMMING
    • METABOLIC SYNDROME
    • METHIONINE RESTRICTION
    • MITOCHONDRIAL UNCOUPLING
    • MONKEYPOX
    • MSG (MONOSOSODIUM GLUTAMATE)
    • MUSCLE FORCE PRODUCTION
    • MUSCLE ATROPHY (PREVENTING)
    • MYOGENESIS
    • MYOSTATIN INHIBITION
    • MYOSTATIN INHIBITION PRESERVES MUSCLE
    • mTORC2
    • mTOR: THE RAPID AGING PATHWAY
    • NATURAL ANTICOAGULANTS
    • NATURAL AROMATASE INHIBITORS
    • NEUROGENESIS (GROWING NEW BRAIN CELLS)
    • NEUROCHEMISTRY OF ADDICTION
    • NEUROPLASTICITY
    • NEUROINFLAMMATION
    • NEUROPROTECTIVE AGENTS
    • NEUTRALIZING OXIDATIVE STRESS WITH MEDICINAL PLANTS
    • NMDA & ANXIETY & DEPRESSION
    • NMDA RECEPTOR & FEAR
    • NON OPIOD ANALGESICS
    • NOOTROPICS
    • NORADRENERGIC
    • NOREPINEPHRINE
    • NRF2: MASTER REGULATOR OF THE AGING PROCESS
    • NF-KB
    • NUTRACEUTICAL
    • OBESOGENS
    • ONCOGENE ACTIVATION INDUCED SENESCENCE
    • ORGANOTINS
    • OVERNUTRITION
    • OXIDATIVE STRESS & AGING
    • P16INK4A
    • P38MAPK
    • P53: TUMOR SUPRESSOR
    • PERIODONTITIS
    • PHOSPHATIDYLINOSITOL 3 KINASE
    • PHYTOCHEMICALS
    • PHYTOSTEROLS
    • PHYTOSTANOLS
    • PHYTOECDYSTEROIDS
    • PROANTHOCYANIDINS
    • PROTEIN CARBONYLATION
    • POLYAMINES & THEIR EFFECT ON BRAIN (NMDA, DEPRESSION, SUICIDE RISK)
    • POLYPHENOLS AS COVID-19 TREATMENT & PREVENTION
    • PPARY2
    • PREMATURE SENESCENCE
    • PREVENTING SKIN AGING
    • PUFAS
    • PURGATIVES
    • RADIATION EXTRACT
    • RAPAMYCIN (MTOR INHIBITION)
    • RED WINE
    • RENAL (KIDNEY) PROTECTIVE AGENTS
    • REMINERALIZATION OF TEETH
    • REMYELINATION
    • REPAIR OF DNA BREAKS “DOUBLE STRAND”
    • RESTORE INSULIN SENSITIVITY
    • REVERSAL OF OBESITY
    • SASP & ADIPOSE TISSUE
    • SEX HORMONE BINDING GLOBULIN
    • SENESCENT CELLS, SASP & SENOLYTICS
    • SENESCENCE-BETA-GALACTOSIDASE (SA-β-gal or SABG)
    • SGLT2 INHIBITORS
    • SGLT2 INHIBITION FOR LIFESPAN EXTENSION
    • SHBG
    • SIRT1
    • SKELETAL MUSCLE HYPERTROPHY (THE SCIENCE OF BUILDING MUSCLE)
    • SKIN ELASTICITY
    • SKIN PHOTOAGING (Preventing & Repairing)
    • SLEEP DEPRIVATION AS THERAPY FOR DEPRESSION
    • SIRT1 & LONGEVITY
    • SMALLPOX
    • SUGAR & AGING
    • STAR PROTEIN
    • STAT3
    • STEM CELL EXHAUSTION
    • STEM CELL REGENERATION
    • STEM CELL THERAPY
    • STIMULATED LIPOLYSYS
    • STEROIDOGENESIS (THE PRODUCTION OF HORMONES IN BODY)
    • STREPTOCOCCUS MUTANS (MAIN BACTERIA BEHIND TOOTH DECAY)
    • STRESS & AGING
    • STRESS & THE BRAIN
    • TELOMERE SHORTENING & PREMATURE AGING
    • TIME RESTRICTED FEEDING
    • THROMBOLYTICS (PLANT BASED)
    • TRAUMATIC BRAIN INJURY (HEALING)
    • TRYPTOPHAN HYDROXYLASE 2
    • VISCERAL ADIPOSITY
    • XENOBIOTICS
    • XENOESTROGEN
  • HOME
  • CONTACT
  • TELEGRAM PORTAL
  • INTERSTELLAR 88/8: EXTREME WEIGHTLOSS PROTOCOL
  • THE ULTIMATE DRY FASTING RESOURCE
  • MY ACCOUNT
  • RESET PASSWORD
0
Pau D’Arco
August 3, 2018
Bilberry
August 17, 2018

Purple Gromwell

Purple Gromwell also known as Lithospermum erythrorhizon, is a plant that has been used in traditional Japanese medicine.





This plant became a big sensation in Japan because of the Shikon cream and Shikon soap. Shikon has been shown to assist in healing of wounds, burns, bruises and cuts. The seeds have been utilized to treat gallbladder and kidney stones because of it's ability to flush out toxins from the body.

Benefits of Purple Gromwell

Anti-Inflammatory - Within the plant of the Purple Gromwell is a chemical known as Shikonin. This chemical was used and tested to show anti-inflammatory properties. Our study suggests shikonin may be a target for the future design of more potent, highly selective therapeutics that could be useful antiinflammatory agents for selectively blocking the binding of CCR1 ligands.

(Article)

In summary, this study demonstrated that shikonin possesses anti-inflammatory activity, which involved the down-regulation of NO, PGE2, and TNF-α, as well as their major regulatory genes, via the suppression of crosstalk between LPS-induced NF-κB activation and ROS production

(Article)  

Anti-Cancer - Lithospermum erythrorhizon has long been used in traditional Asian medicine for the treatment of diseases including skin cancer. The in vitro anticancer studies viz. cell growth, cell cycle and apoptosis, and the expression of tumor regulating proteins were analyzed against B16F10 melanoma cells. LEH induced apoptosis in B16F10 cells by activation of caspase 3 and inducing sub-G1 cell cycle arrest. LEH exhibited both in vitro and in vivo anticancer activity. Shikonin derivatives in the LEH are responsible for the anticancer activity.

(Article)

Shikonin (SK) has been isolated and identified as a key bioactive component in an herbal plant, Shikon (gromwell). In human breast cancer cells, we observed that treatment with SK inhibits tumor cell growth in estrogen receptor α (ERα)-positive, but not ERα-negative breast cancer cells. Finally, co-treatment with SK enhanced sensitivity of breast cancer cells to endocrine therapy. Collectively, our studies suggested that SK has a potential for antihormone therapy in ERα-positive breast cancer cells, and should serve as a target for new drug developments.

(Article)

This study was aimed to investigate whether this chemical could also inhibit cell growth of lung cancer cells and, if so, works via what molecular mechanism. hese results indicate the potential and dose-related cytotoxic actions of shikonin on A549 lung cancer cells via p53-mediated cell fate pathways and raise shikonin a promising adjuvant chemotherapeutic agent for treatment of lung cancer in clinical practice.

(Article)

Apoptosis in Tumor Cells - Shikonin, isolated from the plant Lithospermum erythrorhizon Sieb. Et Zucc, has been reported to induce apoptosis in several tumor cells. However, such effect of shikonin on human breast cancer cells has not been reported. Flow cytometric analysis of shikonin-treated MCF-7 cells showed that the ratio of the apoptotic DNA fragmentation increased in a dose-dependent manner. The present study demonstrated for the first time that the cytotoxic effect of shikonin on MCF-7 cells underwent apoptosis process.

(Article)

Anti - Tumor - When these mice were orally treated with extracts of Shi-ka-ron or each Chinese herbs mentioned above, it showed protective effects to immunosuppressive mice on all 5 items studied. The number of macrophages, and the functions of macrophages and lymphocytes maintained the same or more than normal levels in MMC plus each group of these extracts treated mice. These results suggest that the Shi-Ka-Ron and Chinese herbs could resist immunosuppression induced by antitumor agent MMC, and its mechanisms might be correlated with stimulation of the RES (reticuloendothelial system), activation of T cell blastogenesis and NK cell cytotoxicity.

(Article)

Anti-Obesity - This study aimed to evaluate the antiobesity effects of Lithospermum erythrorhizon ethanol extract (LE) and elucidate the underlying mechanism. Mice were fed a normal or high-fat diet with or without LE supplementation for 8 weeks. These findings suggest that Lithospermum erythrorhizon prevents obesity by inhibiting adipogenesis through downregulation of genes involved in the adipogenesis pathway and may be a useful dietary supplement for the prevention of obesity.

(Article)  

Anti-Bacterial - The objective of this study is to isolate and identify antibacterial compounds from Lithospermum erythrorhizon (L. erythrorhizon). Initially, the extracts of 44 different Traditional Chinese Medicines (TCM) were screened for their antimicrobial sensitivity by using broth micro-dilution methods on 96-microwell plate towards four different species of oral bacteria, which includes Fusobacterium nucleatum, Porphyromonas gingivalis, Streptococcus mutans and Lactobacillus acidophilus. Among the 44 TCMs, the extracts from L. erythrorhizon have proved to be most effective against these bacteria and were taken up for further study. Antibacterial effects of the compounds (Acetylshikonin, shikonin, deoxyshikonin, β-sitosterol, and β, β- dimethylacrylshikonin) obtained from the extract, showed that acetylshikonin has the best antibacterial effects. Our study concludes that acetylshikonin of L. erythrorhizon could be a potential antimicrobial agent for the treatment of oral diseases.

(Article)

Related Products

ORIGINAL

SUPERNOVA

NEBULA

THERMO

TRINITY

THUNDER

SEVEN SAGES

Share
27
Interstellar Blend

Related posts

March 6, 2023

Cuscuta Chinensis


Read more
March 6, 2023

Celery Leaf (Apium Graveolens)


Read more
March 5, 2023

Carduus Crispus


Read more

Comments are closed.

Recent Posts

  • PANCREAS REGENERATION
  • PHTHALATES
  • ENDOCRINE DISRUPTORS
  • RAMADAN
  • GRAPEFRUIT PEEL
© 2023 Interstellar Blends | Activate Your Super Powers!. © 2023 Interstellar Blends | Activate Your Super Powers!. All Rights Reserved.

Mandatory FDA Disclaimer
Privacy Policy
Terms and Conditions
Have Questions?
Contact Gavin Robert McGowen Here

Join the following facebook groups to learn more:
Ultimate Weightloss Challenge , Dry Fasting, Longevity Agents , Interstellar Blend Seven Sages, The Infinitely Postive, THE INTERSTELLAR BLEND CHALLENGE: Fluid Restricted Fasting w/ Superherbs

Love this Website? Contact David Rodriguez to build you one!