The results suggest that prevention of carcinogen‐DNA adduct formation and the antioxidant activity of TNJ may contribute to the cancer preventive effect of Morinda citrifolia.
Roots of Morinda citrifolia (Noni or Yor in Thai) are the source of important compounds, anthraquinones, which have been proven to have anti-viral, anti-bacterial, anti-cancer activities.
In this study, subcritical water extraction was investigated as a benign alternative for solvent extraction of damnacanthal from the dried root of Morinda citrifolia.
The tendency of pol inhibition showed a positive correlation with the suppression of human colon cancer cell HCT116 growth. These results suggested that the Noni root containing anthraquinones may be used as an anticancer functional food.
Based on the foregoing, it can be concluded that the processed Morinda citrifolia products of the present invention inhibit the growth cancerous cells within the colon.
Anti-Tumor - The methanol extract from Morinda citrifolia fruits was tested for cytotoxicity activity on the MTT assay.
A concentration of 0.1 mg/mL of crude extract exhibited cytotoxic activity against breast cancer (MCF7) and neuroblastoma (LAN5) cell lines at 29% and 36%, respectively.
The antitumour activity of Noni‐ppt produced a cure rate of 25%–45% in allogeneic mice and its activity was completely abolished by the concomitant administration of speciﬁc inhibitors of macrophages (2‐chloroadenosine), T cells (cyclosporine) or natural killer (NK) cells (anti‐asialo GM1 antibody).
The combination of Noni‐ppt with imexon, a synthetic immunomodulator, also demonstrated beneﬁcial effects, but not when combined with the MVE‐2 copolymer, a high molecular weight immunomodulator.
Anti-Inflammatory - A new anthraquinone, 1,5,15-tri-O-methylmorindol (1), and two new saccharide fatty acid esters, 2-O-(β-d-glucopyranosyl)-1-O-hexanoyl-β-d-gluropyranose (4) and 2-O-(β-d-glucopyranosyl)-1-O-octanoyl-β-d-gluropyranose (5), have be