This species of mushrooms grows in coniferous woods near spruce or firs and more often than not near higher elevations. You can find these types of mushrooms in the United States, Canada, Japan and Korea. However it is commercially harvested in Queen Charlotte Islands.
These results suggest that Polyozellus multiplex is a candidate for chemoprevention against gastric cancer.
Methanol extract and its fractions of Polyozellus multiplex inhibited the growth of several tumor cell lines and its water fraction showed a higher cytotoxicity effect of the human gastric carcinoma cell, SNU668 than on the other cell lines.
Polozellus multiplex water fraction caused a significant reduction in the proliferating cell nuclear antigen (PCNA) labelling index in the glandular stomach epithelium as compared with the value of MNNG alone.
Anti-Inflammatory - Polyozellin isolated from Polyozellus multiplex (Thelephoraceae) displays potent anti-inflammatory effects in murine macrophages.
Here we evaluated whether polyozellin has the potential to ameliorate diseases characterized by mucosal inflammation in intestinal epithelial HT-29 cells.
These results suggest that polyozellin has the potential to attenuate intestinal inflammation and shed light on the novel signal pathway evoked by TNF-α during intestinal inflammation.
Polyozellin, which has been reported to have a variety of biological activities including antioxidant and anticancer activity, is the major active compound found in edible mushroom (Polyozellus multiplex). In this study, we investigated the antiseptic effects and underlying mechanisms of polyozellin against HMGB1-mediated septic responses in HUVECs and mice.
The anti-inflammatory activities of polyozellin were determined by measuring permeab