All parts of Wedelia chinensis-trilobata plant, including roots, can be used fresh or dried. Internally this herb is usually taken in form of infusions or decoctions, but tinctures and pills are also made, for many common ailments and serious diseases.
Exposure of prostate cancer cells to W. chinensis extract induced apoptosis selectively in androgen receptor (AR)–positive prostate cancer cells and shifted the proportion in each phase of cell cycle toward G2-M phase in AR-negative prostate cancer cells.
Anticancer action of W. chinensis extract was due to three active compounds that inhibit the AR signaling pathway. Oral administration of W. chinensis extract impeded prostate cancer tumorigenesis.
Here it is reported that there are four anti-proliferative phytocompounds in Wedelia chinensis , an oriental herbal medicine, identified through their ability to modulate the androgen receptor (AR) activation of transcription from prostate-specific antigen promoter in PCa cells.
The study has identified synergistic effects of active compounds in W. chinensis and demonstrated their potential in PCa prevention and therapy.
Wedelia chinensis has at least three active compounds, wedelolactone, luteolin, and apigenin synergistically inhibiting prostate cancer cell growth in vitro.
In this study it is reportd a systematic study to develop a standardized and effect-optimized herbal extract, designated as W. chinensis extract (WCE) to facilitate its future scientific validation and clinical use.
Healing Wounds - The wound healing efficacy of ethanolic leaf extract of Wedelia chinensis was evaluated in excision, incision and dead space wound models. The parameters studied include rate of wound contraction, period of complete epithelialization, tensile strength of incision wound and, granulation tissue dry weight.
Its ethanolic extract was found to possess significant wound healing activity, which was evidenced by decrease in the period of epithelialization, increase in the rate of wound contraction, skin breaking strength, granulation tissue dry weight, and its breaking strength.