One use in particular is the ability of youth and eye sight. This plant is part of the family known as Araceae, many other names are the Japanese Rush. The main flowering time of this plant is from May to June and it fruits from July to August.
These results demonstrated that AGR and URE have a protective effect against ischemia-induced neuronal loss and learning and memory damage. Our studies suggest that AGR and URE may be useful in the treatment of vascular dementia.
In the present study, the ameliorating effects of an essential oil extracted from Acori graminei rhizoma on learning and memory in aged, dysmnesia rats and mice were determined using the step‐down passive avoidance test and Y maze.
The results suggest that the essential oil improves cognitive function in aged animals possibly by increasing norepinephrine, dopamine and serotonin relative levels, and by decreasing the activity of acetylcholinesterase in the cerebra.
Hippocampal Neurogenesis - This study aimed to investigate the neuroprotective effects of different extract fractions from Acori graminei Rhizoma (AGR) against Alzheimer disease-like symptoms induced by Amyloid Beta (Aß) 1-42 intra-hippocampal injection. On day 7 after intra-hippocampal injection of saline or Aβ1-42, spatial memory was assessed by the first Morris water maze, followed by 3-week intra-gastric administration of saline or water extract, volatile oil fraction, or defatted decoction fraction of AGR respectively.
Our results suggested that treatment with these different extract fractions from AGR could ameliorate cognitive impairment and down-regulate expressions of doublecortin and nestin in the hippocampus of Aβ1-42 injected mice, in which water extract and volatile oil fractions were more effectively in spatial memory than defatted decoction fraction.
Alzheimer’s Disease – They investigated the effects of different fractions of Acori graminei rhizoma extracts on the learning and memory abilities in amyloid β-protein(Aβ)-induced Alzheimer disease(AD) mice.
Compared with AD plus saline group,the activity of NOS in the cerebrum and hippocampus,and the quantities of the positive cells were significantly decreased in AD plus Acori graminei rhizome groups
The different fractions of Acori graminei rhizome extracts improve the learning and memory abilities in AD mice induced by Aβ1-42.This effect might be related to the decrease in NOS activity.
Spatial Memory - Acori graminei Rhizoma (AGR), the dry rhizoma of Acorus gramineus Soland (Araceae), has been used as an Asian traditional herbal medicine against senile dementia, stroke, and cardiovascular disease.
This study aimed to investigate the neuroprotective effects of different extract fractions from AGR against Alzheimer disease-like symptoms induced by Amyloid Beta (Aß) 1-42 intra-hippocampal injection.
Results suggested that treatment with these different extract fractions from AGR could ameliorate cognitive impairment and down-regulate expressions of doublecortin and nestin in the hippocampus of Aβ1-42 injected mice, in which water extract and volatile oil fractions were more effective in spatial memory than defatted decoction fraction.
Neuroprotective - Acori graminei rhizoma (AGR) are reported to exhibit a number of pharmacological actions in the central nervous system.
These results demonstrated that the methanol extract of AGR exhibited protective action against excitotoxic neuronal death, and that the neuroprotective action was primarily due to the blockade of NMDA receptor function by the interaction with the glycine binding site of the receptor.