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    ANTI-INFLAMMATORY EFFECTS OF FLAVONOIDS & POLYPHENOLS
    January 20, 2020
    BCL-W
    January 22, 2020
     

    Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL

    Senescent cells, formed in response to physiological and oncogenic stresses, facilitate protection from tumourigenesis and aid in tissue repair. However, accumulation of such cells in tissues contributes to age-related pathologies. Resistance of senescent cells to apoptotic stimuli may contribute to their accumulation, yet the molecular mechanisms allowing their prolonged viability are poorly characterized. Here we show that senescent cells upregulate the anti-apoptotic proteins BCL-W and BCL-XL. Joint inhibition of BCL-W and BCL-XL by siRNAs or the small-molecule ABT-737 specifically induces apoptosis in senescent cells. Notably, treatment of mice with ABT-737 efficiently eliminates senescent cells induced by DNA damage in the lungs as well as senescent cells formed in the epidermis by activation of p53 through transgenic p14ARF. Elimination of senescent cells from the epidermis leads to an increase in hair-follicle stem cell proliferation. The finding that senescent cells can be eliminated pharmacologically paves the way to new strategies for the treatment of age-related pathologies.

    1. 1088: Novel Bispecific Antisense Oligonucleotides Inhibiting Both Bcl-2 And Bcl-Xl Expression Induce Apoptosis And Enhance Chemosensitivity In Human …
    2. 130 Regulates Cardiac Myocyte Survival In Doxorubicin-Induced Apoptosis Through Phosphatidylinositol 3-Kinase/Akt Phosphorylation And Bcl-Xl/Caspase-3 Interaction
    3. 148 Epidermal Growth Factor Induces Bcl-Xl Gene Expression And Reduces Apoptosis In Porcine Parthenotes Developing In Vitro
    4. 168 Molecular Interaction Between Bcl-Xl And Bnip3 Determines The Cell Fate Of Hypertrophic Chondrocytes
    5. 1-Bp Inhibits Nf-Κb Activity And Bcl-Xl Expression In Astrocytes In Vitro And Reduces Bcl-Xl Expression In The Brains Of Rats In Vivo
    6. 201. A Bcl-Xl Antisense Antisense Antisense Adenoviral V Adenoviral V Adenoviral Vector: A Novel And Novel And Effective Pro-Apoptotic Gene Therapy Construct
    7. 21P Role Of Cytoplasmic Bcl-Xl In Interplay Apoptosis And Autophagy In Combination Of Genistein With Radiation-Induced Cell Death
    8. 2249081. Bcl-Xl Transformed Peanut (Arachis Hypogaea L.) Exhibits Paraquat Tolerance
    9. 2-Methoxy Antimycin Reveals A Unique Mechanism For Bcl-Xl Inhibition
    10. 3′-Deoxy-3′-18F-Fluorothymidine Pet/Ct To Guide Therapy With Epidermal Growth Factor Receptor Antagonists And Bcl-Xl Inhibitors In Non–Small Cell Lung Cancer
    11. 326-Lb: Bcl-Xl/Bcl2L1 Is A Critical Anti-Apoptotic Protein That Suppresses Bak To Promote Pancreatic Specification From Human Pluripotent Stem Cells
    12. 3D-Qsar Pharmacophore Modeling And In Silico Screening Of New Bcl-Xl Inhibitors
    13. 3-Thiomorpholin-8-Oxo-8H-Acenaphtho [1, 2-B] Pyrrole-9-Carbonitrile (S1) Derivatives As Pan-Bcl-2-Inhibitors Of Bcl-2, Bcl-Xl And Mcl-1
    14. 4 Monoclonal Antibody, Induces Death Receptor 4-Mediated Apoptotic Cell Death In Anaplastic Thyroid Cancer Cells Via Downregulation Of Bcl-Xl With Reactive Oxygen …
    15. 4-1Bb Promotes The Survival Of Cd8+ T Lymphocytes By Increasing Expression Of Bcl-Xl And Bfl-1
    16. 5‐Azacytidine Specifically Inhibits The Nih‐3T3 Pcd Process Induced By Tnf‐Alpha And Cycloheximide Via Affecting Bcl‐Xl
    17. 834. Protective Effect Of Bcl-Xl Gene Expression On The Radiation-Induced Acute Intestinal Injuries
    18. 86 Mesenchymal Stem Cells Induce Lymphocytes Apoptosis Independent Of Bim And Bcl-Xl In Lupus Mice
    19. 926. Bcl-Xl Gene Transfer Improves Graft Survival And Prolongs The Cold-Preservation Time In The Heart Transplantation
    20. 947. Rnai-Mediated Bcl-Xl Depletion Sensitizes Pancreatic Cancer Cells To Tnf [Alpha] Induced Apoptosis
    21. 947. Rnai-Mediated Bcl-Xl Depletion Sensitizes Pancreatic Cancer Cells To Tnfα Induced Apoptosis
    22. 97P At-101 (-/-Gossypol) In Combination With Trastuzumab Triggers Apoptosis Through Inhibiting Bcl-2, Bcl-Xl And Mcl-1 Protein …
    23. A Bcl-Xl Timer Sets Platelet Life Span
    24. A Bcl-Xl Transgene Promotes Malignant Conversion Of Chemically Initiated Skin Papillomas
    25. A Biodegradable Polymersome Containing Bcl‐Xl Sirna And Doxorubicin As A Dual Delivery Vehicle For A Synergistic Anticancer Effect
    26. A Brewing Understanding Of The Regulation Of Bax Function By Bcl-Xl And Bcl-2
    27. A Caspase-Resistant Form Of Bcl-Xl, But Not Wild Type Bcl-Xl, Promotes Clonogenic Survival After Ionizing Radiation
    28. A Central Role Of Bcl-Xl In The Regulation Of Keratinocyte Survival By Autocrine Egfr Ligands
    29. A Combination Of In Silico And Sar Studies To Identify Binding Hot Spots Of Bcl-Xl Inhibitors
    30. A Combination Of Sulindac And Arsenic Trioxide Synergistically Induces Apoptosis In Human Lung Cancer H1299 Cells Via C-Jun Nh2-Terminal Kinase-Dependent Bcl-Xl …
    31. A Comparison Of The Properties Of A Bcl-Xl Variant To The Wild-Type Anti-Apoptosis Inhibitor In Mammalian Cell Cultures
    32. A Conserved Hydrophobic Core At Bcl-Xl Mediates Its Structural Stability And Binding Affinity With Bh3-Domain Peptide Of Pro-Apoptotic Protein
    33. A Cytoskeleton-Based Functional Genetic Screen Identifies Bcl-Xl As An Enhancer Of Metastasis, But Not Primary Tumor Growth
    34. A Dige Approach For The Assessment Of Differential Expression Of The Cho Proteome Under Sodium Butyrate Addition: Effect Of Bcl‐Xl Overexpression
    35. A Dimeric Sesquiterpenoid From A Malaysian Meiogyne As A New Inhibitor Of Bcl-Xl/Bakbh3 Domain Peptide Interaction
    36. A Dynamic Role For Bcl-Xl In Cellular Metabolism And Apoptosis: Calcium Regulation At The Er-Mitochondria Interface
    37. A Fluorescence Based Method For Studying The Membrane Topology Of The Anti-Apoptotic Protein Bcl-Xl
    38. A Functionally Improved Locked Nucleic Acid Antisense Oligonucleotide Inhibits Bcl-2 And Bcl-Xl Expression And Facilitates Tumor Cell Apoptosis
    39. A General Strategy For The Bacterial Expression Of Amyloidogenic Peptides Using Bcl‐Xl‐1/2 Fusions
    40. A High Soy Diet Enhances Neurotropin Receptor And Bcl-Xl Gene Expression In The Brains Of Ovariectomized Female Rats
    41. A High Soy Diet Reduces Programmed Cell Death And Enhances Bcl-Xl Expression In Experimental Stroke
    42. A Let-7B Binding Site Snp In The 3′-Utr Of The Bcl-Xl Gene Enhances Resistance To 5-Fluorouracil And Doxorubicin In Breast Cancer Cells
    43. A New Assay Based On Fluorescence Resonance Energy Transfer To Determine The Binding Affinity Of Bcl-Xl Inhibitors
    44. A New Assay For The Discovery Of Bcl-Xl Inhibitors
    45. A New Model To Study Spinal Muscular Atrophy: Neurite Degeneration And Cell Death Is Counteracted By Bcl-Xl Overexpression In Motoneurons
    46. A Novel Bcl-2/Bcl-Xl Dual Inhibitor Overcomes Ibrutinib-Resistance Conferred By The Upregulation Of Integrin Pathway And Bcl-Xl
    47. A Novel Bcl-2/Bcl-Xl Inhibitor Apg-1252-12A As A Potential Therapeutic Strategy For Gastric Carcinoma
    48. A Novel Bcl-2/Xl Inhibitor Induces Tumor Cell Apoptosis And Potentiates The Activity Of Standard Chemotherapeutics
    49. A Novel Bcl-Xl Inhibitor Z36 That Induces Autophagic Cell Death In Hela Cells
    50. A Novel Bim-Bh3-Derived Bcl-Xl Inhibitor: Biochemical Characterization, In Vitro, In Vivo And Ex-Vivo Anti-Leukemic Activity
    51. A Novel Bispecific Antisense Oligonucleotide Inhibiting Both Bcl-2 And Bcl-Xl Expression Efficiently Induces Apoptosis In Tumor Cells
    52. A Novel Combination Treatment Targeting Bcl-Xl And Mcl1 For Kras/Braf-Mutated And Bcl2L1-Amplified Colorectal Cancers
    53. A Novel Fluorescent-Based Assay Reveals That Thrombopoietin Signaling And Bcl-Xl Influence, Respectively, Platelet And Erythrocyte Lifespans
    54. A Novel Histone Deacetylase Inhibitor, Cg200745, Potentiates Anticancer Effect Of Docetaxel In Prostate Cancer Via Decreasing Mcl-1 And Bcl-Xl
    55. A Novel Mechanism Of Irinotecan Targeting Mdm2 And Bcl-Xl
    56. A Novel Myd88 Mutation, L265Rpp, In Waldenström Macroglobulinemia Activates The Nf-Κb Pathway To Upregulate Bcl-Xl Expression And Enhances Cell …
    57. A Novel Naphthalimide Compound Restores P53 Function In Non-Small Cell Lung Cancer By Reorganizing The Bak· Bcl-Xl Complex And Triggering Transcriptional …
    58. A Novel Proanthocyanidin Ih636 Grape Seed Extract Increases In Vivo Bcl-Xl Expression And Prevents Acetaminophen-Induced Programmed And Unprogrammed Cell …
    59. A Novel Pten/Mutant P53/C-Myc/Bcl-Xl Axis Mediates Context-Dependent Oncogenic Effects Of Pten With Implications For Cancer Prognosis And Therapy
    60. A Novel Role Of Bax, Bak In Cell Cycle Function Of Bcl2 And Bcl-Xl
    61. A Novel Therapeutic Combination Sequentially Targeting Aurora B And Bcl-Xl In Hepatocellular Carcinoma
    62. A Phase I Study Of Novel Dual Bcl-2/Bcl-Xl Inhibitor Apg-1252 In Patients With Advanced Small Cell Lung Cancer (Sclc) Or Other Solid Tumor.
    63. A Physiologic Role Of Bcl-Xl Induced In Activated Macrophages
    64. A Potent And Highly Efficacious Bcl-2/Bcl-Xl Inhibitor
    65. A Potent Bh3 Mimetic Targeting Bcl-Xl Induces Apoptosis Regulated By Pten Loss And Integrin Alpha 5 In Prostate Cancer Cells
    66. A Protein Derived From The Fusion Of Tat Peptide And Fnk, A Bcl‐Xl Derivative, Prevents Cochlear Hair Cell Death From Aminoglycoside Ototoxicity In Vivo
    67. A Randomized Trial Of Laryngeal Organ Preservation Evaluating Two Cycles Of Induction Chemotherapy With Platinum, Docetaxel, And A Novel Bcl-Xl Inhibitor.
    68. A Relationship Between 5-Lipoxygenase-Activating Protein And Bcl-Xl Expression In Murine Pro-B Lymphocytic Fl5. 12 Cells
    69. A Role For Bcl-Xl In Cd1D-Mediated Natural Killer T Cell Responses To B Cells (46.39)
    70. A Series Of Phytochemicals Prevents Acetaminophen-Induced Programmed And Unprogrammed Cell Deaths By Enhancing Bcl-Xl Expression And Minimizing …
    71. A Signal Network Involving Coactivated Nf‐Κb And Stat3 And Altered P53 Modulates Bax/Bcl‐Xl Expression And Promotes Cell Survival Of Head And Neck Squamous …
    72. A Small Inhibitor Of The Interaction Between Bax And Bcl-Xl Can Synergize With Methylprednisolone To Induce Apoptosis In Bcl-Xl-Overexpressing Breast-Cancer Cells
    73. A Small-Molecule Inhibitor Of Bcl-Xl Potentiates The Activity Of Cytotoxic Drugs In Vitro And In Vivo
    74. A Synthetic Bcl-Xl Antagonist Induces Apoptosis And Chemosensitization In Malignant Pleural Mesothelioma
    75. A Three–Dimensional Electron Tomographic Analysis Of Rod Photoreceptor Synaptic Terminal Mitochondria In Control, Lead–Exposed, And/Or Bcl–Xl Transgenic …
    76. A2A Adenosine Receptor Mediates Hepg2 Cell Apoptosis By Downregulating Bcl‐Xl Expression And Upregulating Bid Expression
    77. Aav-Mediated Expression Of Bcl-Xl Or Xiap Fails To Induce Neuronal Resistance Against Quinolinic Acid-Induced Striatal Lesioning
    78. Aberrant Expression Of Tctp Protein Inhibits Cell Apoptosis By Up-Regulating Bcl-Xl In Human Pancreatic Cancer
    79. Abl-Myc Retroviral Infection Elicits Bone Marrow Plasma Cell Tumors In Bcl-Xl Transgenic Mice
    80. Absence Of Bcl-Xl Down-Regulation In Response To Cisplatin Is Associated With Chemoresistance In Ovarian Carcinoma Cells
    81. Abstract B09: Targeting The Anti-Apoptotic Protein Mcl-1 With The Mtor Inhibitor Rad001 Sensitizes Luminal Breast Cancers To The Bcl-2/Bcl-Xl Inhibitor Abt-263
    82. Abstract B217: Antitumor Activity Of The New Bcl-2/Bcl-Xl Inhibitor S44563 In Primary Human Uveal Melanoma Xenografts.
    83. Abstract B33: Beyond Apoptosis, Bcl-Xl In Metastasis
    84. Abstract B42: The Regulation Of The Er-Mitochondria-Ca2+ Cross-Talk By Bcl-2 And Bcl-Xl: A New Scenario For The Development Of Selective Tools In Oncology?
    85. Abstract C250: Concurrent Targeting Bcl-2/Bcl-Xl And Mdm2 As A New Therapeutic Strategy For Acute Leukemia.
    86. Abstract C263: Mtor Inhibition Specifically Sensitizes Colorectal Cancers With Kras Or Braf Mutations To Bcl-2/Bcl-Xl Inhibition By Suppressing Mcl-1.
    87. Abstract P1-09-08: Bcl2L1 (Bcl-Xl) Expression And Myc Super-Enhancer Positivity Predict Sensitivity To The Covalent Cdk7 Inhibitor Sy-1365 In Triple Negative …
    88. Abstract P4-14-02: Neutralization Of Bcl2/Bcl-Xl Enhances The Cytotoxicity Of T-Dm1 In Vivo
    89. Abstract Pr09: Synthetic Lethal Interaction Of Combined Bcl-Xl And Mek Inhibition Promotes Tumor Regressions In Kras-Mutant Cancer Models
    90. Abstract# 1958: Bcl2L12 Contains A Bh3 Like Motif Capable Of Antagonising Bcl-2 And Bcl-Xl And Is Proapoptotic.
    91. Abstract# 2049: Inhibition Of Notch Enhances Pro-Apoptotic Effect Of Bcl-2/Bcl-Xl Inhibitor In Multiple Myeloma
    92. Abstract# 3263: Analysis Of The Functional Significance Of Phosphorylation Of Bcl-Xl Induced By Microtubule Inhibitors
    93. Abstract# 3693: Sorafenib Inhibits Stat3-Regulated Expression Of Prosurvival Mcl-1 And Bcl-Xl Proteins To Enhance Trail-Mediated Apoptosis In Human Pancreatic …
    94. Abstract# 3865: Cdk1-Mediated Phosphorylation And Inactivation Of Bcl-Xl/Bcl-2: A Functional Link Between Mitotic Arrest And Apoptosis
    95. Abstract# 3978: Radiation Induced Nitration Of Bcl-2/Bcl-Xl And The Regulation Of Apoptosis
    96. Abstract# 4100: Impact Of Bcl-Xl Deficiency In Mouse Keratinocytes On Susceptibility To Both Uvb-And Chemically-Induced Skin Carcinogenesis
    97. Abt-737 Inhibits Full Length And Cleaved Pro-Apoptotic Bcl-Xl, Resulting In Differential Effects On Death And Survival
    98. Abt-737 Reverses The Acquired Radioresistance Of Breast Cancer Cells By Targeting Bcl-2 And Bcl-Xl
    99. Abt-737, A Small Molecule Bcl-2/Bcl-Xl Antagonist, Increases Antimitotic-Mediated Apoptosis In Human Prostate Cancer Cells
    100. Abt-737, A Small Molecule Bcl-2/Bcl-Xl Antagonist, Increases Docetaxel-Mediated Apoptosis In Human Prostate Cancer Cells
    101. Acetaminophen Induces A Caspase‐Dependent And Bcl‐Xl Sensitive Apoptosis In Human Hepatoma Cells And Lymphocytes
    102. Acetylation Of The Proto-Oncogene Evi1 Abrogates Bcl-Xl Promoter Binding And Induces Apoptosis
    103. Acid Destabilization Of The Solution Conformation Of Bcl‐Xl Does Not Drive Its Ph‐Dependent Insertion Into Membranes
    104. Acidic Preconditioning Increases Expression Of Bcl-Xl And Suppresses
    105. Acidic Preconditioning Protects Endothelial Cells Against Apoptosis Through P38-And Akt-Dependent Bcl-Xl Overexpression
    106. Acidic Pre‐Conditioning Suppresses Apoptosis And Increases Expression Of Bcl‐Xl In Coronary Endothelial Cells Under Simulated Ischaemia
    107. Acquisition Of Resistance To Apoptosis And Necrosis By Bcl‐Xl Over‐Expression In Rat Hepatoma Mca‐Rh8994 Cells
    108. Activated Grass Carp Stat6 Up-Regulates The Transcriptional Level And Expression Of Ccl20 And Bcl-Xl
    109. Activated Ras Prevents Downregulation Of Bcl-Xl Triggered By Detachment From The Extracellular Matrix: A Mechanism Of Ras-Induced Resistance To Anoikis In Intestinal …
    110. Activation Of A Non-Genomic Pim-1/Bad-Pser75 Module Is Required For An Efficient Pro-Survival Effect Of Bcl-Xl Induced By Androgen In Lncap Cells
    111. Activation Of Caspases Occurs Downstream From Radical Oxygen Species Production, Bcl-Xl Down-Regulation, And Early Cytochrome C Release In Apoptosis Induced By …
    112. Activation Of Ets-2 By Oxidative Stress Induces Bcl-Xl Expression And Accounts For Glial Survival In Amyotrophic Lateral Sclerosis
    113. Activation Of Extracellular Signal‐Regulated Kinases Erk1 And Erk2 Induces Bcl‐Xl Up‐Regulation Via Inhibition Of Caspase Activities In Erythropoietin Signaling
    114. Activation Of Fas By Fasl Induces Apoptosis By A Mechanism That Cannot Be Blocked By Bcl-2 Or Bcl-Xl
    115. Activation Of Lxrβ Causes Metabolic Reprogramming And Sensitizes Solid Tumors To Bcl-Xl Inhibition Mediated Apoptosis
    116. Activation Of Lxrβ Inhibits Tumor Respiration And Is Synthetically Lethal With Bcl‐Xl Inhibition
    117. Activation Of P38 Mapk-Regulated Bcl-Xl Signaling Increases Survival Against Zoledronic Acid-Induced Apoptosis In Osteoclast Precursors
    118. Activation Of The Cpp32 Apoptotic Protease By Distinct Signaling Pathways With Differential Sensitivity To Bcl-Xl
    119. Activation Of The P38Mapk Signaling Pathway And Over-Expression Of Bcl-2/Bcl-Xl In Patients With DlBcl: Potential Biomarkers And Targets For Therapeutics. A …
    120. Activity Induces Apoptosis Of Chronic Myelogenous Leukemia Cells By Suppressing Signal Transducer And Activator Of Transcription 5–Dependent Expression Of Bcl-Xl
    121. Activity Of A Novel Bcl-2/Bcl-Xl-Bispecific Antisense Oligonucleotide Against Tumors Of Diverse Histologic Origins
    122. Activity Of Selenium On Cell Proliferation, Cytotoxicity, And Apoptosis And On The Expression Of Casp9, Bcl-Xl And Apc In Intestinal Adenocarcinoma Cells
    123. Adenosine Activates Ampk To Phosphorylate Bcl-Xl Responsible For Mitochondrial Damage And Diablo Release In Huh-7 Cells
    124. Adenoviral Transfer Of Mda-7 Leads To Bax Up-Regulation And Apoptosis In Mesothelioma Cells, And Is Abrogated By Over-Expression Of Bcl-Xl
    125. Adenovirus-Mediated Bcl-Xl Expression Using A Neuron-Specific Synapsin-1 Promoter Protects Against Disseminated Neuronal Injury And Brain Infarction Following …
    126. Adenovirus-Mediated Bcl-Xl Gene Therapy Combined With Pronase Treatment Protects The Small Intestine From Radiation-Induced Enteritis In Mouse Model
    127. Adenovirus-Mediated Gene Transfer Of Bcl-Xl Prevents Cell Death In Primary Neuronal Culture Of The Rat
    128. Adenovirus-Mediated Sirna Targeting Bcl-Xl Inhibits Proliferation, Reduces Invasion And Enhances Radiosensitivity Of Human Colorectal Cancer Cells
    129. Adenovirus‐Mediated Small Hairpin Rna Targeting Bcl‐Xl As Therapy For Colon Cancer
    130. Adenovirus-Mediated Transfer Of Bcl-Xl Protects Neuronal Cells From Bax-Induced Apoptosis
    131. Adipocyte Microenvironment Promotes BclXl Expression And Confers Chemoresistance In Ovarian Cancer Cells
    132. Advanced Glycation End Products Influence Oral Cancer Cell Survival Via Bcl-Xl And Nrf-2 Regulation In Vitro
    133. After Embedding In Membranes Antiapoptotic Bcl-Xl Protein Binds Both Bcl-2 Homology Region 3 And Helix 1 Of Proapoptotic Bax Protein To Inhibit Apoptotic …
    134. Aid-Deficient Bcl-Xl Transgenic Mice Develop Delayed Atypical Plasma Cell Tumors With Unusual Ig/Myc Chromosomal Rearrangements
    135. Ajuba Overexpression Regulates Mitochondrial Potential And Glucose Uptake Through Yap/Bcl-Xl/Glut1 In Human Gastric Cancer
    136. Akt And Bcl-Xl Promote Growth Factor-Independent Survival Through Distinct Effects On Mitochondrial Physiology
    137. Akt1 Drives Endothelial Cell Membrane Asymmetry And Microglial Activation Through Bcl-Xl And Caspase 1, 3, And 9
    138. Alpha-Tocotrienol Prevents Oxidative Stress-Mediated Post-Translational Cleavage Of Bcl-Xl In Primary Hippocampal Neurons
    139. Alterations In Eicosanoid Levels During U937 Bcl-Xl Tumour Growth Suppression And Recovery In Nu/Nu Mice In Vivo—Involvement Of Phospholipase A2
    140. Alterations In The Characteristic Size Distributions Of Subcellular Scatterers At The Onset Of Apoptosis: Effect Of Bcl-Xl And Bax/Bak
    141. Altered Bad Localization And Interaction Between Bad And Bcl-Xl In The Hippocampus After Transient Global Ischemia
    142. Amyloid Fibrils Formed By The Programmed Cell Death Regulator Bcl-Xl
    143. An Il‐2 Receptor Β Subdomain That Controls Bcl‐Xl Expression And Cell Survival
    144. An Increase In Glucosylceramide Synthase Induces Bcl-Xl-Mediated Cell Survival In Vinorelbine-Resistant Lung Adenocarcinoma Cells
    145. An Interaction Between Bcl-Xl And The Voltage-Dependent Anion Channel (Vdac) Promotes Mitochondrial Ca2+ Uptake
    146. An Interaction Between Bcl-Xl And Vdac Facilitates Mitochondrial Ca2+ Uptake And Bioenergetics
    147. An Oncogenic Tyrosine Kinase Inhibits Dna Repair And Bcl-Xl Deamidation In T Cell Transformation
    148. An Oncogenic Tyrosine Kinase Inhibits Dna Repair And Dna-Damage-Induced Bcl-Xl Deamidation In T Cell Transformation
    149. Anacardic Acids From Knema Hookeriana As Modulators Of Bcl-Xl/Bak And Mcl-1/Bid Interactions
    150. Analysis Of Dynamic Changes In The Proteome Of A Bcl‐Xl Overexpressing Chinese Hamster Ovary Cell Culture During Exponential And Stationary Phases
    151. Analysis Of Flexibility And Hotspots In Bcl-Xl And Mcl-1 Proteins For The Design Of Selective Small-Molecule Inhibitors
    152. Analysis Of Intracellular Proapoptotic (Bax, Bak) And Antiapoptotic (Bcl-2, Bcl-Xl) Proteins Expression In Thyrocytes From Young Patients With Immune And Non-Immune …
    153. Analysis Of Ribosyl-Modified, Mixed Backbone Analogs Of A Bcl-2/Bcl-Xl Antisense Oligonucleotide
    154. And Cysteamine Supplementation During In Vitro Production Of Buffalo (Bubalus Bubalis) Embryos Affect Mrna Expression Of Bcl‐2, Bcl‐Xl, Mcl‐1, Bax And Bid
    155. And Low Mitochondrial Membrane Potential Decrease Susceptibility To Apoptosis And Do Not Modulate The Protective Effect Of Bcl-Xl In Osteosarcoma Cells
    156. Androgen Receptor‐Dependent Regulation Of Bcl‐Xl Expression: Implication In Prostate Cancer Progression
    157. Angiostatic Effects Of Nk Cell-Derived Ifn-C Counteracted By Tumour Cell Bcl-Xl Expression
    158. Angiotensin-Ii-Induced Apoptosis Requires Regulation Of Nucleolin And Bcl-Xl By Shp-2 In Primary Lung Endothelial Cells
    159. Animal Cell-Death Suppressors Bcl-Xl And Ced-9 Inhibit Cell Death In Tobacco Plants
    160. Antagonist Chlorpromazine And Poly (Adp-Ribose) Polymerase Modulators 4-Aminobenzamide And Nicotinamide Influence Hepatic Expression Of Bcl-Xl And P53 And …
    161. Antagonistic Effect Of Insulin-Like Growth Factor I On Protein Kinase Inhibitor—Mediated Apoptosis In Human Glioblastoma Cells In Association With Bcl-2 And Bcl-Xl
    162. Anti-Apoptosis Effect Of Astragaloside Iv On Alzheimer’S Disease Rat Model Via Enhancing The Expression Of Bcl-2 And Bcl-Xl
    163. Anti-Apoptosis Effect Of Bcl-Xl On Retinal Ganglion Cells By Ultrasound-Mediated Microbubble Destruction
    164. Anti-Apoptosis Proteins Mcl-1 And Bcl-Xl Have Different P53-Binding Profiles
    165. Antiapoptotic Bcl-2 And Bcl-Xl In Advanced Malignant Melanoma
    166. Anti‐Apoptotic Bcl‐Xl Protein In Complex With Bh3 Peptides Of Pro‐Apoptotic Bak, Bad, And Bim Proteins: Comparative Molecular Dynamics Simulations
    167. Anti-Apoptotic Genes Bcl-2 And Bcl-Xl Overexpression Can Block Iridovirus Serine/Threonine Kinase-Induced Bax/Mitochondria-Mediated Cell Death In Gf-1 Cells
    168. Antiapoptotic Marker, Bcl-Xl, Expression On Reed-Sternberg Cells Of Hodgkin’S Disease Using A Novel Monoclonal Marker, Yth-2H12
    169. Anti-Apoptotic Protein Bcl-Xl Expression In The Midbrain Raphe Region Is Sensitive To Stress And Glucocorticoids
    170. Antiapoptotic Protein Bcl-Xl Is Up-Regulated During Megakaryocytic Differentiation Of Cd34+ Progenitors But Is Absent From Senescent Megakaryocytes
    171. Antiapoptotic Proteins Bcl-2 And Bcl-Xl Inhibit Clostridium Difficile Toxin A-Induced Cell Death In Human Epithelial Cells
    172. Anticancer And Chemosensitizing Effects Of 2, 3-Dcpe In Ovarian Carcinoma Cell Lines: Link With Erk Activation And Modulation Of P21Waf1/Cip1, Bcl-2 And Bcl-Xl …
    173. Anti-Hla Class I Antibody–Mediated Activation Of The Pi3K/Akt Signaling Pathway And Induction Of Bcl-2 And Bcl-Xl Expression In Endothelial Cells
    174. Anti-Immunoglobulin-Induced Apoptosis In Wehi 231 Cells Involves The Slow Formation Of Ceramide From Sphingomyelin And Is Blocked By Bcl-Xl
    175. Antisense Activity Of 2′,4′-Bna Targeted To Bcl-Xl Gene In Hepg2 Cell
    176. Antisense Bcl-Xl Down-Regulation Switches The Response To Topoisomerase I Inhibition From Senescence To Apoptosis In Colorectal Cancer Cells, Enhancing Global …
    177. Antisense Downregulation Of The Apoptosis-Related Bcl-2 And Bcl-Xl Proteins: A New Approach To Cancer Therapy
    178. Antisense Oligonucleotide Inhibition Of Bcl-Xl And Bid Expression In Liver Regulates Responses In A Mouse Model Of Fas-Induced Fulminant Hepatitis
    179. Antisense Oligonucleotides Directed At The Bcl-Xl Gene Product Augment Chemotherapy Response In Mesothelioma
    180. Antisense Oligonucleotides Targeting Y-Box Binding Protein-1 Inhibit Tumor Angiogenesis By Downregulating Bcl-Xl-Vegfr2/-Tie Axes
    181. Antisense Rna Down-Regulation Of Bcl-Xl Expression In Prostate Cancer Cells Leads To Diminished Rates Of Cellular Proliferation And Resistance To Cytotoxic …
    182. Antisense Therapy For Malignant Mesothelioma With Oligonucleotides Targeting The Bcl-Xl Gene Product
    183. Antisense-And Sirna-Mediated Inhibition Of The Anti-Apoptotic Gene Bcl-Xl For Chemosensitization Of Bladder Cancer Cells
    184. Anti-Tumor Effect Of Adenovirus-Mediated Bcl-Xl Shrna In Vitro
    185. Antitumor Evaluation Of The New Bcl‐2/Bcl‐Xl Inhibitor S44563 In Primary Human Uveal Melanoma Xenografts
    186. Anti-Tumor Pyrimidinylpiperazines Bind To The Prosurvival Bcl-2 Protein Family Member Bcl-Xl
    187. Apaf-1, Bcl-Xl, Cytochrome C, And Caspase-9 Form The Critical Elements For Cerebral Vascular Protection By Erythropoietin
    188. Apg-1252-12A Induces Mitochondria-Dependent Apoptosis Through Inhibiting The Antiapoptotic Proteins Bcl-2/Bcl-Xl In Hl-60 Cells
    189. Apigenin Induces Apoptosis By Suppressing Bcl-Xl And Mcl-1 Simultaneously Via Signal Transducer And Activator Of Transcription 3 Signaling In Colon Cancer
    190. Apoptosis And Adenocarcinoma Of The Cardia: Expression Of P53, Bcl-2, Bcl-Xl, Waf1, And Fas Proteins And Association With Characteristics Of The Tumors.
    191. Apoptosis And Expression Of Bcl-2, Bcl-Xl, And Bax In Renal Cell Carcinomas
    192. Apoptosis And The Conformational Change Of Bax Induced By Proteasomal Inhibition Of Pc12 Cells Are Inhibited By Bcl-Xl And Bcl-2
    193. Apoptosis Blocks Beclin 1-Dependent Autophagosome Synthesis: An Effect Rescued By Bcl-Xl
    194. Apoptosis By Gemcitabine In Non-Small Cell Lung Cancer Cell Line Kns62 Is Induced Downstream Of Caspase 8 And Is Profoundly Blocked By Bcl-Xl Over-Expression
    195. Apoptosis In P53 Protein-Deficient Cells Is Mediated By Bh3-Only Protein-Independent Derepression Of Bak Protein Through Down-Regulation Of Mcl-1 And Bcl-Xl …
    196. Apoptosis Induced By Ultraviolet B Radiation And Cd95 Ligation–Differential Protection Through Epidermal Growth Factor Receptor Activation And Bcl-Xl …
    197. Apoptosis Induces Bcl-Xs And Cleaved Bcl-Xl In Chronic Lymphocytic Leukaemia
    198. Apoptosis Inhibiting Factor Bcl-Xl Might Be The Crucial Member Of The Bcl-2 Gene Family In Colorectal Cancer
    199. Apoptosis Is Augmented In High-Grade Serous Ovarian Cancer By The Combined Inhibition Of Bcl-2/Bcl-Xl And Parp
    200. Apoptosis Of Articular Chondrocytes In Osteoarthritis With Degree Of Cartilage Destruction And Expression Of Apoptosis-Related Proteins: Surviving, Caspase-3, And Bcl-Xl
    201. Apoptosis Of Canine Mammary Tumor Cells Induced By Small Interfering Rna (Sirna) Against Bcl-Xl Gene
    202. Apoptosis Of Germ Cells And Expressions Of Bcl-Xl And Bad In Rats With Experimental Kidney-Yang Deficiency [J]
    203. Apoptosis Of Prostate Cancer By Inhibition Of Bcl-Xl Expression
    204. Apoptosis Protection By The Epo Target Bcl-Xl Allows Factor-Independent Differentiation Of Primary Erythroblasts
    205. Apoptosis Regulation By Bcl-Xl Modulation Of Mammalian Inositol 1, 4, 5-Trisphosphate Receptor Channel Isoform Gating
    206. Apoptosis Triggered By Myc-Induced Suppression Of Bcl-Xl Or Bcl-2 Is Bypassed During Lymphomagenesis
    207. Apoptosis-Modulating Interaction Of The Neuregulin/Erbb Pathway With Antracyclines In Regulating Bcl-Xs And Bcl-Xl In Cardiomyocytes
    208. Apoptotic Cell Death And Altered Calcium Homeostasis Caused By Frataxin Depletion In Dorsal Root Ganglia Neurons Can Be Prevented By Bh4 Domain Of Bcl-Xl Protein
    209. Apoptotic Characteristics Of Spleen Lymphocyte In Mice Irradiated By Lethal Dose And Its Relationship To The Expression Of Bax And Bcl-Xl Proteins
    210. Apoptotic Effect Of Bcl-Xl Antisense Oligodeoxynucleotide Mediated By Lipofectin On Cell Strain Cne-2Z
    211. Apoptotic Response Of Lung Adenocarcinoma Cells To Pi3K/Akt Inhibition Is Augmented By Bcl-Xl Down-Regulation.
    212. Apoptotic Responsiveness Of Pc-3 Prostate Cancer Cells To Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand: Evidence For Differential Effects Of Bcl-Xl And Bcl-2 …
    213. Application Of Combination Of Short Hairpin Rna Segments For Silencing Vegf, Tert, And Bcl-Xl Expression In Laryngeal Squamous Carcinoma
    214. Aptamer-Targeted Delivery Of Bcl-Xl Shrna Using Alkyl Modified Pamam Dendrimers Into Lung Cancer Cells
    215. Are Associated With High Apoptotic Index, High Expression Of The Proapoptotic Proteins Bax, Bak And Bid And Low Expression Of The Antiapoptotic Protein Bcl-Xl
    216. Arf Induces Autophagy By Virtue Of Interaction With Bcl-Xl
    217. Arginine Antimetabolite L-Canavanine Induces Apoptotic Cell Death In Human Jurkat T Cells Via Caspase-3 Activation Regulated By Bcl-2 Or Bcl-Xl
    218. Arsenic Trioxide Enhances Sti571-Induced Apoptosis Of K562 Cells Through Downregulating Bcl-Xl And Bcr-Abl.
    219. Arthritis Patients Express Functional Il-15 Receptor Complex: Endogenous Il-15 In Autocrine Fashion Enhances Cell Proliferation And Expression Of Bcl-Xl And Bcl-2
    220. Assessing Tumor Progression Factors By Somatic Gene Transfer Into A Mouse Model: Bcl-Xl Promotes Islet Tumor Cell Invasion
    221. Assessment Of Bcl-2, Bcl-Xl And Mcl-1 In Bone Marrow Biopsy Samples Using Ventana Benchmark Xt Automated Slide Stainer
    222. Assessment Of Expressions Of Bcl-Xl, B-Fgf, Bmp-2, Caspase-3, Pdgfr-?, Smad1 And Tgf-ß1 Genes In A Rat Model Of Lung Ischemia/Reperfusion
    223. Assessment Of Expressions Of Bcl-Xl, B-Fgf, Bmp-2, Caspase-3, Pdgfr-Α, Smad1 And Tgf-Β1 Genes In A Rat Model Of Lung Ischemia/Reperfusion
    224. Association Between Bcl-Xl And 5-Lipoxygenase Activating Protein (Flap) Levels In Il-3-Dependent Fl5. 12 Cells
    225. Association Between Virulence Factors And Traf1/4-1Bb/Bcl-Xl Expression In Gastric Mucosa Infected With Helicobacter Pylori
    226. Association Of Bcl-2, Bax, Bcl-Xl And Interleukin-1 Beta-Converting Enzyme Expression With Initial Response To Chemotherapy In Acute Myeloid Leukemia.
    227. Association Of Cell Growth Modalities In Vitro With Its Heterogenous Expression Of Bcl-Xl In Relapsed Acute Myelogenous Leukemic Cells
    228. Ataxin-3 Protects Cells Against H2O2-Induced Oxidative Stress By Enhancing The Interaction Between Bcl-Xl And Bax
    229. Atf3 Repression Of Bcl-Xl Determines Apoptotic Sensitivity To Hdac Inhibitors Across Tumor Types
    230. Atypical Antipsychotics Attenuate Neurotoxicity Of Β‐Amyloid(25–35) By Modulating Bax And Bcl‐Xl/S Expression And Localization
    231. Aurora B Inhibitor Tak-901 Synergizes With Bcl-Xl Inhibition By Inducing Active Bax In Cancer Cells
    232. Autophagy Is Activated, But Is Not Required For The G0 Function Of Bcl-2 Or Bcl-Xl
    233. Autophagy Protein Lc3 Regulates The Fibrosis Of Hypertrophic Scar By Controlling Bcl-Xl In Dermal Fibroblasts
    234. Aven And Bcl‐Xl Enhance Protection Against Apoptosis For Mammalian Cells Exposed To Various Culture Conditions
    235. Aven And Bcl-Xl Expression Pattern And Protein-Protein Interaction Assessment Through Bovine Early Embryo Development
    236. Aven Blocks Dna Damage-Induced Apoptosis By Stabilising Bcl-Xl
    237. Aven, A Novel Inhibitor Of Caspase Activation, Binds Bcl-Xl And Apaf-1
    238. B001: Apoptosis Of Endothelial Cells Leads To Paracrine Induction Of Bcl-Xl In Vascular Smooth Muscle Cells
    239. Backbone Space In Foldamers Containing Α‐And Β‐Amino Acid Residues: Developing Protease‐Resistant Oligomers That Bind Tightly To The Bh3‐Recognition Cleft Of Bcl‐Xl
    240. Bad Induces Apoptosis In Cells Over-Expressing Bcl-2 Or Bcl-Xl Without Loss Of Mitochondrial Membrane Potential
    241. Bad Is A Bh3 Domain-Containing Protein That Forms An Inactivating Dimer With Bcl-Xl.
    242. Bad Ser-155 Phosphorylation Regulates Bad/Bcl-Xl Interaction And Cell Survival
    243. Bad, A Heterodimeric Partner For Bcl-Xl And Bcl-2, Displaces Bax And Promotes Cell Death
    244. Bak Bh3 Peptides Antagonize Bcl-Xl Function And Induce Apoptosis Through Cytochrome C-Independent Activation Of Caspases
    245. Bax Activation By Engagement With, Then Release From, The Bh3 Binding Site Of Bcl-Xl
    246. Bax And Bcl-Xl Exert Their Regulation On Different Sites Of The Ceramide Channel
    247. Bax And Bcl-Xl Expression Are Not Related To Prognosis In Patients With Advanced Esophageal Squamous Cell Carcinoma
    248. Bax Can Antagonize Bcl-Xl During Etoposide And Cisplatin-Induced Cell Death Independently Of Its Heterodimerization With Bcl-Xl
    249. Bax Mitochondrial Relocation Is Linked To Its Phosphorylation And Its Interaction With Bcl-Xl
    250. Bax, Bcl-Xl Exert Their Regulation On Different Sites On The Ceramide Channel
    251. Bax, But Not Bcl-Xl, Decreases The Lifetime Of Planar Phospholipid Bilayer Membranes At Subnanomolar Concentrations
    252. Bax/Bcl-Xl Gene Expression Ratio Inversely Correlates With Disease Progression In Chronic Myeloid Leukemia
    253. Bax-Independent Inhibition Of Apoptosis By Bcl-Xl
    254. Bax-Induced Caspase Activation And Apoptosis Via Cytochromec Release From Mitochondria Is Inhibitable By Bcl-Xl
    255. Bcl 2 And Bcl Xl Are Key Determinants Of Resistance To Antitubulin Chemotherapeutics In Melanoma Cells
    256. Bcl 2 And Bcl-Xl Are Candidate Targets For Growth Inhibition Of Breast Cancer Cells Using Sirna Lipoplexes
    257. Bcl-2 And Bcl-Xl Antagonize The Mitochondrial Dysfunction Preceding Nuclear Apoptosis Induced By Chemotherapeutic Agents
    258. Bcl-2 And Bcl-Xl Antisense Oligonucleotides Induce Apoptosis In Melanoma Cells Of Different Clinical Stages
    259. Bcl-2 And Bcl-Xl Are Important For The Induction Of Paclitaxel Resistance In Human Hepatocellular Carcinoma Cells
    260. Bcl-2 And Bcl-Xl Are Indispensable For The Late Phase Of Mast Cell Development From Mouse Embryonic Stem Cells
    261. Bcl-2 And Bcl-Xl Block Apoptosis As Well As Necrosis: Possible Involvement Of Common Mediators In Apoptotic And Necrotic Signal Transduction Pathways.
    262. Bcl-2 And Bcl-Xl Block Thapsigargin-Induced Nitric Oxide Generation, C-Jun Nh2-Terminal Kinase Activity, And Apoptosis
    263. Bcl-2 And Bcl-Xl Dual Inhibitor, Abt-737, Circumvents Jnk Mediated Upregulation Of Anti-Apoptotic Molecules In Cisplatin Treated Non-Small Cell Lung Cancer Models
    264. Bcl-2 And Bcl-Xl Expression Are Down-Regulated In Benign Prostate Hyperplasia Nodules And Not Affected By Finasteride And/Or Celecoxib
    265. Bcl-2 And Bcl-Xl Inhibit Cd95-Mediated Apoptosis By Preventing Mitochondrial Release Of Smac/Diablo And Subsequent Inactivation Of X-Linked Inhibitor-Of-Apoptosis …
    266. Bcl-2 And Bcl-Xl Inhibit Fas-Mediated Apoptosis Of Salivary Epithelial Cells
    267. Bcl-2 And Bcl-Xl Mediate Resistance To Receptor Tyrosine Kinase-Targeted Therapy In Lung And Gastric Cancer.
    268. Bcl-2 And Bcl-Xl Overexpression Inhibits Cytochrome C Release, Activation Of Multiple Caspases, And Virus Release Following Coxsackievirus B3 Infection
    269. Bcl‐2 And Bcl‐Xl Play Important Roles In The Crosstalk Between Autophagy And Apoptosis
    270. Bcl-2 And Bcl-Xl Regulate Proinflammatory Caspase-1 Activation By Interaction With Nalp1
    271. Bcl-2 And Bcl-Xl Restrict Lineage Choice During Hematopoietic Differentiation
    272. Bcl-2 And Bcl-Xl Suppress Glucose Signaling In Pancreatic Β-Cells
    273. Bcl-2 Gene And Its Family Genes Bax, Bcl-Xl As Well As Fas/Apo-1 And Their Clinical Significance In Acute Leukemia.
    274. Bcl-2 Is A Better Abt-737 Target Than Bcl-Xl Or Bcl-W And Only Noxa Overcomes Resistance Mediated By Mcl-1, Bfl-1, Or Bcl-B
    275. Bcl-2 Or Bcl-Xl Gene Therapy Increases Neural Plasticity Proteins Nestin And C-Fos Expression In Pc12 Cells
    276. Bcl-2 Or Bcl-Xl Gene Therapy Reduces Apoptosis And Increases Plasticity Protein Gap-43 In Pc12 Cells
    277. Bcl-2 Or Bcl-Xl Overexpression Stimulates Both Oxidative And Fermentative Components Of Carbohydrate Metabolism
    278. Bcl-2 Or Bcl-Xl Overexpression Stimulates Lactic Fermentation Without Affecting Whole Cell Respiration
    279. Bcl-2 Or Bcl-Xl Overexpresssion Affects Both Lactic Fermentation And Mitochondrial Metabolism In Growing Pro-Lymphocytes
    280. Bcl-2, Bax And Bcl-Xl Expression In Human Sensitive And Resistant Leukemia Cell Lines
    281. Bcl-2, Bax, Bcl-Xl And Bcl-Xs Expression In Neoplastic And Normal Cervical Tissue
    282. Bcl-2, Bax, Bcl-Xl And Bcl-Xs Expression In Neoplastic And Normal Endometrium
    283. Bcl-2, Bax, Bcl-Xl, And Bcl-X Expression In Normal And Neoplastic Ovarian Tissues’
    284. Bcl-2, Bax, Bcl-Xl, And Bcl-Xs Expression In Normal And Neoplastic Ovarian Tissues.
    285. Bcl-2, Bax, Bcl-Xs, Bcl-Xl Expression And Significant Of Myocardium In Heart Failure Rats [J]
    286. Bcl-2, Bcl-Xl And C-Flipl Potentially Regulate The Susceptibility Of Human Peripheral Blood Monocyte-Derived Dendritic Cells To Cell Death At Different Developmental …
    287. Bcl-2, Bcl-Xl Sequester Bh3 Domain-Only Molecules Preventing Bax-And Bak-Mediated Mitochondrial Apoptosis
    288. Bcl-2, Bcl-Xl, And P-Akt Are Involved In Neuroprotective Effects Of Transcription Factor Brn3B In An Ocular Hypertension Rat Model Of Glaucoma
    289. Bcl-2, Bcl-Xl, And Pp32/Phapi In Resected Non-Small-Cell Lung Cancer Patients.
    290. Bcl-2/Bcl-Xl Bispecific Antisense Treatment Sensitizes Breast Carcinoma Cells To Doxorubicin, Paclitaxel And Cyclophosphamide
    291. Bcl-2/Bcl-Xl Inhibition Increases The Efficacy Of Mek Inhibition Alone And In Combination With Pi3 Kinase Inhibition In Lung And Pancreatic Tumor Models
    292. Bcl‐2/Bcl‐Xl Inhibition Predominantly Synergistically Enhances The Anti‐Neoplastic Activity Of A Low‐Dose Cusp9 Repurposed Drug Regime Against Glioblastoma
    293. Bcl‑2/Bcl‑Xl Inhibitor Abt‑737 Sensitizes Pancreatic Ductal Adenocarcinoma To Paclitaxel‑Induced Cell Death
    294. Bcl2/Bcl-Xl Inhibitor Engenders Apoptosis And Increases Chemo-Sensitivity In Mesothelioma
    295. Bcl-2/Bcl-Xl Mediate Ros Production In Pancreatic Cancer Cells Leading To The Inhibition Of Apoptosis
    296. Bcl-2/Bcl-Xl Regulates Cell Cycle Through A Novel Mechanism In Addition To Cell Survival
    297. Bcl-Xl Acts Downstream Of Caspase-8 Activation By The Cd95 Death-Inducing Signaling Complex
    298. Bcl-Xl Affects Ca2+ Homeostasis By Altering Expression Of Inositol 1, 4, 5-Trisphosphate Receptors
    299. Bcl-Xl Affects Group A Streptococcus-Induced Autophagy Directly, By Inhibiting Fusion Between Autophagosomes And Lysosomes, And Indirectly, By Inhibiting …
    300. Bcl-Xl Affects The Development Of Functional Cd4 Tregs
    301. Bcl-Xl And Bak Protein Expression In Human Optic Nerve Axons In Eyeballs Post-Trauma And In The Eyes With Absolute Glaucoma.
    302. Bcl-Xl And Bcl-2 Expression In Bilharzial Squamous Cell Carcinoma Of The Urinary Bladder: Which Protein Is Prognostic?
    303. Bcl‐Xl And Bcl‐2 Expression In Squamous Cell Carcinoma Of The Head And Neck
    304. Bcl-Xl And Bcl-2 Proteins In Melanoma Progression And Uvb-Induced Apoptosis
    305. Bcl-Xl And Bcl-2 Repress A Common Pathway Of Cell Death.
    306. Bcl-Xl And Calyculin A Prevent Translocation Of Bax To Mitochondria During Apoptosis
    307. Bcl-Xl And Caspase Inhibition Increase The Survival Of Rat Oxytocin And Vasopressin Magnocellular Neurons In Organotypic Culture
    308. Bcl-Xl And E1B-19K Proteins Inhibit P53-Induced Irreversible Growth Arrest And Senescence By Preventing Reactive Oxygen Species-Dependent P38 Activation
    309. Bcl-Xl And Il-6 Act Independently And Synergistically To Accelerate Plasmacytopoiesis And Plasma Cell Tumor Formation In Balb/C Mice.
    310. Bcl-Xl And Mcl-1 Are Involved In Prevention Of In Vitro Apoptosis In Rat Late-Stage Erythroblasts Derived From Bone Marrow
    311. Bcl-Xl And Mcl-1 Are The Key Bcl-2 Family Proteins In Melanoma Cell Survival
    312. Bcl-Xl And Mcl-1 Are The Major Determinants Of The Apoptotic Response To Dual Pi3K And Mek Blockage
    313. Bcl‐Xl And Mcl‐1 Constitute Pertinent Targets In Ovarian Carcinoma And Their Concomitant Inhibition Is Sufficient To Induce Apoptosis
    314. Bcl-Xl And Mcl-1 Upregulation By Calreticulin Promotes Apoptosis Resistance Of Fibroblast-Like Synoviocytes Via Activation Of Pi3K/Akt And Stat3 Pathways In …
    315. Bcl-Xl And Myeloid Cell Leukaemia-1 Contribute To Apoptosis Resistance Of Colorectal Cancer Cells
    316. Bcl‐Xl And Stat3 Mediate Malignant Actions Of Γ‐Irradiation In Lung Cancer Cells
    317. Bcl-Xl And Uvrag Cause A Monomer-Dimer Switch In Beclin1
    318. Bcl-Xl Anti-Apoptotic Network Is Dispensable For Development And Maintenance Of Cml But Is Required For Disease Progression Where It Represents A New Therapeutic …
    319. Bcl-Xl Anti-Apoptotic Network Is Dispensable For Emergence And Maintenance Of Cml But Required For Disease Progression, And Represents An Alternative Target For …
    320. Bcl-Xl Antisense Oligodeoxynucleotide Sensitizes Human Esophageal Cancer Cell Line To 5-Fluorouracil
    321. Bcl‐Xl Antisense Oligonucleotide And Cisplatin Combination Therapy Extends Survival In Scid Mice With Established Mesothelioma Xenografts
    322. Bcl-Xl Antisense Oligonucleotides Chemosensitize Human Glioblastoma Cells
    323. Bcl-Xl Antisense Oligonucleotides Coupled With Antennapedia Enhances Radiation-Induced Apoptosis In Pancreatic Cancer
    324. Bcl‐Xl Antisense Oligonucleotides Induce Apoptosis And Increase Sensitivity Of Pancreatic Cancer Cells To Gemcitabine
    325. Bcl‐Xl Antisense Sensitizes Human Colon Cancer Cell Line To 5‐Fluorouracil
    326. Bcl‐Xl Antisense Treatment Induces Apoptosis In Breast Carcinoma Cells
    327. Bcl-Xl Antisense Treatment Sensitizes Bcl-Xl-Overexpressing Squamous Cell Carcinoma Cells To Carboplatin
    328. Bcl-Xl As A Critical Apoptosis Antagonist In Hepatocytes And Hepatocellular Carcinoma
    329. Bcl‐Xl As A Fusion Protein For The High‐Level Expression Of Membrane‐Associated Proteins
    330. Bcl-Xl As A Poor Prognostic Biomarker And Predictor Of Response To Adjuvant Chemotherapy Specifically In Braf-Mutant Stage Ii And Iii Colon Cancer
    331. Bcl-Xl As A Poor Prognostic Biomarker And Predictor Of Response To Adjuvant Chemotherapy Specifically In-Mutant Stage Ii And Iii Colon Cancer
    332. Bcl-Xl As A Radiosensitizer In The Treatment Of Group C Medulloblastoma
    333. Bcl-Xl As An Antiapoptotic Molecule For Cardiomyocytes.
    334. Bcl-Xl As The Most Promising Bcl-2 Family Member In Targeted Treatment Of Chondrosarcoma
    335. Bcl-Xl Blocks A Mitochondrial Inner Membrane Channel And Prevents Ca2+ Overload-Mediated Cell Death
    336. Bcl-Xl Blocks Activation Of Related Adhesion Focal Tyrosine Kinase/Proline-Rich Tyrosine Kinase 2 And Stress-Activated Protein Kinase/C-Jun N-Terminal Protein Kinase In …
    337. Bcl-Xl Blocks High Dose Doxorubicin-Induced Apoptosis But Not Low Dose Doxorubicin-Induced Cell Death Through Mitotic Catastrophe
    338. Bcl‐Xl Blocks Mitochondrial Multiple Conductance Channel Activation And Inhibits 6‐Ohda‐Induced Death In Sh‐Sy5Y Cells
    339. Bcl-Xl Blocks Transforming Growth Factor-Β1-Induced Apoptosis By Inhibiting Cytochrome C Release And Not By Directly Antagonizing Apaf-1-Dependent Caspase …
    340. Bcl-Xl Blocks Tumor Necrosis Factor Alpha-Induced Caspase 8 Activation And Apoptosis
    341. Bcl-Xl Can Inhibit Apoptosis In Cells That Have Undergone Fas-Induced Protease Activation
    342. Bcl-Xl Confers Multi-Drug Resistance In Several Squamous Cell Carcinoma Cell Lines
    343. Bcl-Xl Conformational Changes Upon Fragment Binding Revealed By Nmr
    344. Bcl-Xl Controls A Switch Between Cell Death Modes During Mitotic Arrest
    345. Bcl-Xl Cooperatively Associates With The Bap31 Complex In The Endoplasmic Reticulum, Dependent On Procaspase-8 And Ced-4 Adaptor
    346. Bcl-Xl Deamidation A Trigger For Apoptosis
    347. Bcl-Xl Deamidation And Cancer: Charting The Fame Trajectories Of Legitimate Child And Hidden Siblings
    348. Bcl-Xl Deamidation In Oncogenic Tyrosine Kinase Signalling
    349. Bcl-Xl Deamidation Is A Critical Switch In The Regulation Of The Response To Dna Damage
    350. Bcl-Xl Deamidation Is Regulated By Multiple Ion Transporters And Is Intramolecularly Catalyzed
    351. Bcl-Xl Deamidation: Its Consequences And Regulation
    352. Bcl-Xl Dependence Predicts Response To Alvocidib In Chronic Lymphocytic Leukemia Patients
    353. Bcl-Xl Dependency Coincides With The Onset Of Neurogenesis In The Developing Mammalian Spinal Cord
    354. Bcl-Xl Depletion Promotes Apoptosis And Retards Growth Of Pancreatic Cancer Tumor Xenografts
    355. Bcl-Xl Destabilization Of Ceramide Channels: Role Of The Hydrophobic Groove
    356. Bcl-Xl Determines The Metabolic Efficiency Of Neurons, Through Interaction With Mitochondrial Atp Synthase
    357. Bcl-Xl Dimerization By Three-Dimensional Domain Swapping
    358. Bcl-Xl Directly Modulates Ras Signalling To Favour Cancer Cell Stemness
    359. Bcl-Xl Directly Retrotranslocates The Monomeric Bak
    360. Bcl-Xl Displays Restricted Distribution During T Cell Development And Inhibits Multiple Forms Of Apoptosis But Not Clonal Deletion In Transgenic Mice.
    361. Bcl-Xl Disrupts Death-Inducing Signal Complex Formation In Plasma Membrane Induced By Hypoxia/Reoxygenation
    362. Bcl-Xl Does Not Have To Bind Bax To Protect T Cells From Death
    363. Bcl-Xl Downregulation Using Short Hairpin Rna (Shrna) Sensitises Hct-116 Colon Cancer Cells To Topoisomerase I Inhibition
    364. Bcl-Xl Dynamics And Cancer-Associated Mutations Under The Lens Of Protein Structure Networks And Biomolecular Simulations
    365. Bcl-Xl Enhances Single-Cell Survival And Expansion Of Human Embryonic Stem Cells Without Affecting Self-Renewal
    366. Bcl-Xl Expression After Contusion To The Rat Spinal Cord
    367. Bcl-Xl Expression And Cisplatin Resistance In Head And Neck Squamous Cell Carcinoma Cells
    368. Bcl-Xl Expression And Its Relationships With Clinical Pathological Characteristics, Expression Of Estrogen And Progestogen Receptors In Breast Cancer
    369. Bcl-Xl Expression And Mutation In Non-Hodgkin’S Lymphoma
    370. Bcl-Xl Expression Correlates With Primary Macrophage Differentiation, Activation Of Functional Competence, And Survival And Results From Synergistic Transcriptional …
    371. Bcl-Xl Expression Improves The Therapeutic Effect Of Human Umbilical Cord Stem Cell Transplantation On Articular Cartilage Injury In Rabbit
    372. Bcl-Xl Expression In Multiple Myeloma
    373. Bcl‐Xl Expression In Stem Cells Facilitates Engraftment And Reduces The Need For Host Conditioning During Bone Marrow Transplantation
    374. Bcl‐Xl Expression Interferes With The Effects Of L‐Glutamine Supplementation On Hybridoma Cultures
    375. Bcl-Xl Expression Is Druggable Biomarker Associated With A Poor Clinical Outcome In Relapsed/Refractory Diffuse Large B-Cell Lymphoma (DlBcl)
    376. Bcl-Xl Expression Is Essential For Human Erythropoiesis And Engraftment Of Hematopoietic Stem Cells
    377. Bcl-Xl Expression Levels Influence Differential Regional Astrocytic Susceptibility To 1, 3-Dinitrobenzene
    378. Bcl-Xl Forms An Ion Channel In Synthetic Lipid Membranes
    379. Bcl-Xl Forms Two Distinct Homodimers At Non-Ionic Detergents: Implications In The Dimerization Of Bcl-2 Family Proteins
    380. Bcl-Xl Functions Downstream Of Caspase-8 To Inhibit Fas-And Tumor Necrosis Factor Receptor 1-Induced Apoptosis Of Mcf7 Breast Carcinoma Cells
    381. Bcl-Xl Gain Of Function And P19Arf Loss Of Function Cooperate Oncogenically With Myc In Vivo By Distinct Mechanisms
    382. Bcl-Xl Gene Expression Correlated With Lower Apoptotic Cell Numbers And Shorter Progression-Free Survival In Pcfcl
    383. Bcl-Xl Gene Transfer Inhibits Bax Translocation And Prolongs Cardiac Cold Preservation Time In Rats
    384. Bcl-Xl Gene Transfer Protects The Heart Against Ischemia/Reperfusion Injury
    385. Bcl-Xl Genetic Modification Enhanced The Therapeutic Efficacy Of Mesenchymal Stem Cell Transplantation In The Treatment Of Heart Infarction
    386. Bcl-Xl In Neuroprotection And Plasticity
    387. Bcl-Xl In Prostate Cancer Cells: Effects Of Overexpression And Down-Regulation On Chemosensitivity
    388. Bcl-Xl Increases Axonal Numbers But Not Axonal Elongation From Rat Retinal Explants
    389. Bcl-Xl Increases Bax Mitochondrial Localization And Activation In Non-Apoptotic Cells
    390. Bcl-Xl Increases Mitochondrial Fission, Fusion, And Biomass In Neurons
    391. Bcl-Xl Induces Drp1-Dependent Synapse Formation In Cultured Hippocampal Neurons
    392. Bcl-Xl Inhibition By Molecular-Targeting Drugs Sensitizes Human Pancreatic Cancer Cells To Trail
    393. Bcl-Xl Inhibition Enhances Dinaciclib-Induced Cell Death In Soft-Tissue Sarcomas.