Senescent cells, formed in response to physiological and oncogenic stresses, facilitate protection from tumourigenesis and aid in tissue repair. However, accumulation of such cells in tissues contributes to age-related pathologies. Resistance of senescent cells to apoptotic stimuli may contribute to their accumulation, yet the molecular mechanisms allowing their prolonged viability are poorly characterized. Here we show that senescent cells upregulate the anti-apoptotic proteins BCL-W and BCL-XL. Joint inhibition of BCL-W and BCL-XL by siRNAs or the small-molecule ABT-737 specifically induces apoptosis in senescent cells. Notably, treatment of mice with ABT-737 efficiently eliminates senescent cells induced by DNA damage in the lungs as well as senescent cells formed in the epidermis by activation of p53 through transgenic p14ARF. Elimination of senescent cells from the epidermis leads to an increase in hair-follicle stem cell proliferation. The finding that senescent cells can be eliminated pharmacologically paves the way to new strategies for the treatment of age-related pathologies.
ANTI-INFLAMMATORY EFFECTS OF FLAVONOIDS & POLYPHENOLS
January 20, 2020
BCL-W
January 22, 2020- 1088: Novel Bispecific Antisense Oligonucleotides Inhibiting Both Bcl-2 And Bcl-Xl Expression Induce Apoptosis And Enhance Chemosensitivity In Human …
- 130 Regulates Cardiac Myocyte Survival In Doxorubicin-Induced Apoptosis Through Phosphatidylinositol 3-Kinase/Akt Phosphorylation And Bcl-Xl/Caspase-3 Interaction
- 148 Epidermal Growth Factor Induces Bcl-Xl Gene Expression And Reduces Apoptosis In Porcine Parthenotes Developing In Vitro
- 168 Molecular Interaction Between Bcl-Xl And Bnip3 Determines The Cell Fate Of Hypertrophic Chondrocytes
- 1-Bp Inhibits Nf-Κb Activity And Bcl-Xl Expression In Astrocytes In Vitro And Reduces Bcl-Xl Expression In The Brains Of Rats In Vivo
- 201. A Bcl-Xl Antisense Antisense Antisense Adenoviral V Adenoviral V Adenoviral Vector: A Novel And Novel And Effective Pro-Apoptotic Gene Therapy Construct
- 21P Role Of Cytoplasmic Bcl-Xl In Interplay Apoptosis And Autophagy In Combination Of Genistein With Radiation-Induced Cell Death
- 2249081. Bcl-Xl Transformed Peanut (Arachis Hypogaea L.) Exhibits Paraquat Tolerance
- 2-Methoxy Antimycin Reveals A Unique Mechanism For Bcl-Xl Inhibition
- 3′-Deoxy-3′-18F-
Fluorothymidine Pet/Ct To Guide Therapy With Epidermal Growth Factor Receptor Antagonists And Bcl-Xl Inhibitors In Non–Small Cell Lung Cancer - 326-Lb: Bcl-Xl/Bcl2L1 Is A Critical Anti-Apoptotic Protein That Suppresses Bak To Promote Pancreatic Specification From Human Pluripotent Stem Cells
- 3D-Qsar Pharmacophore Modeling And In Silico Screening Of New Bcl-Xl Inhibitors
- 3-Thiomorpholin-8-Oxo-8H-
Acenaphtho [1, 2-B] Pyrrole-9-Carbonitrile (S1) Derivatives As Pan-Bcl-2-Inhibitors Of Bcl-2, Bcl-Xl And Mcl-1 - 4 Monoclonal Antibody, Induces Death Receptor 4-Mediated Apoptotic Cell Death In Anaplastic Thyroid Cancer Cells Via Downregulation Of Bcl-Xl With Reactive Oxygen …
- 4-1Bb Promotes The Survival Of Cd8+ T Lymphocytes By Increasing Expression Of Bcl-Xl And Bfl-1
- 5‐Azacytidine Specifically Inhibits The Nih‐3T3 Pcd Process Induced By Tnf‐Alpha And Cycloheximide Via Affecting Bcl‐Xl
- 834. Protective Effect Of Bcl-Xl Gene Expression On The Radiation-Induced Acute Intestinal Injuries
- 86 Mesenchymal Stem Cells Induce Lymphocytes Apoptosis Independent Of Bim And Bcl-Xl In Lupus Mice
- 926. Bcl-Xl Gene Transfer Improves Graft Survival And Prolongs The Cold-Preservation Time In The Heart Transplantation
- 947. Rnai-Mediated Bcl-Xl Depletion Sensitizes Pancreatic Cancer Cells To Tnf [Alpha] Induced Apoptosis
- 947. Rnai-Mediated Bcl-Xl Depletion Sensitizes Pancreatic Cancer Cells To Tnfα Induced Apoptosis
- 97P At-101 (-/-Gossypol) In Combination With Trastuzumab Triggers Apoptosis Through Inhibiting Bcl-2, Bcl-Xl And Mcl-1 Protein …
- A Bcl-Xl Timer Sets Platelet Life Span
- A Bcl-Xl Transgene Promotes Malignant Conversion Of Chemically Initiated Skin Papillomas
- A Biodegradable Polymersome Containing Bcl‐Xl Sirna And Doxorubicin As A Dual Delivery Vehicle For A Synergistic Anticancer Effect
- A Brewing Understanding Of The Regulation Of Bax Function By Bcl-Xl And Bcl-2
- A Caspase-Resistant Form Of Bcl-Xl, But Not Wild Type Bcl-Xl, Promotes Clonogenic Survival After Ionizing Radiation
- A Central Role Of Bcl-Xl In The Regulation Of Keratinocyte Survival By Autocrine Egfr Ligands
- A Combination Of In Silico And Sar Studies To Identify Binding Hot Spots Of Bcl-Xl Inhibitors
- A Combination Of Sulindac And Arsenic Trioxide Synergistically Induces Apoptosis In Human Lung Cancer H1299 Cells Via C-Jun Nh2-Terminal Kinase-Dependent Bcl-Xl …
- A Comparison Of The Properties Of A Bcl-Xl Variant To The Wild-Type Anti-Apoptosis Inhibitor In Mammalian Cell Cultures
- A Conserved Hydrophobic Core At Bcl-Xl Mediates Its Structural Stability And Binding Affinity With Bh3-Domain Peptide Of Pro-Apoptotic Protein
- A Cytoskeleton-Based Functional Genetic Screen Identifies Bcl-Xl As An Enhancer Of Metastasis, But Not Primary Tumor Growth
- A Dige Approach For The Assessment Of Differential Expression Of The Cho Proteome Under Sodium Butyrate Addition: Effect Of Bcl‐Xl Overexpression
- A Dimeric Sesquiterpenoid From A Malaysian Meiogyne As A New Inhibitor Of Bcl-Xl/Bakbh3 Domain Peptide Interaction
- A Dynamic Role For Bcl-Xl In Cellular Metabolism And Apoptosis: Calcium Regulation At The Er-Mitochondria Interface
- A Fluorescence Based Method For Studying The Membrane Topology Of The Anti-Apoptotic Protein Bcl-Xl
- A Functionally Improved Locked Nucleic Acid Antisense Oligonucleotide Inhibits Bcl-2 And Bcl-Xl Expression And Facilitates Tumor Cell Apoptosis
- A General Strategy For The Bacterial Expression Of Amyloidogenic Peptides Using Bcl‐Xl‐1/2 Fusions
- A High Soy Diet Enhances Neurotropin Receptor And Bcl-Xl Gene Expression In The Brains Of Ovariectomized Female Rats
- A High Soy Diet Reduces Programmed Cell Death And Enhances Bcl-Xl Expression In Experimental Stroke
- A Let-7B Binding Site Snp In The 3′-Utr Of The Bcl-Xl Gene Enhances Resistance To 5-Fluorouracil And Doxorubicin In Breast Cancer Cells
- A New Assay Based On Fluorescence Resonance Energy Transfer To Determine The Binding Affinity Of Bcl-Xl Inhibitors
- A New Assay For The Discovery Of Bcl-Xl Inhibitors
- A New Model To Study Spinal Muscular Atrophy: Neurite Degeneration And Cell Death Is Counteracted By Bcl-Xl Overexpression In Motoneurons
- A Novel Bcl-2/Bcl-Xl Dual Inhibitor Overcomes Ibrutinib-Resistance Conferred By The Upregulation Of Integrin Pathway And Bcl-Xl
- A Novel Bcl-2/Bcl-Xl Inhibitor Apg-1252-12A As A Potential Therapeutic Strategy For Gastric Carcinoma
- A Novel Bcl-2/Xl Inhibitor Induces Tumor Cell Apoptosis And Potentiates The Activity Of Standard Chemotherapeutics
- A Novel Bcl-Xl Inhibitor Z36 That Induces Autophagic Cell Death In Hela Cells
- A Novel Bim-Bh3-Derived Bcl-Xl Inhibitor: Biochemical Characterization, In Vitro, In Vivo And Ex-Vivo Anti-Leukemic Activity
- A Novel Bispecific Antisense Oligonucleotide Inhibiting Both Bcl-2 And Bcl-Xl Expression Efficiently Induces Apoptosis In Tumor Cells
- A Novel Combination Treatment Targeting Bcl-Xl And Mcl1 For Kras/Braf-Mutated And Bcl2L1-Amplified Colorectal Cancers
- A Novel Fluorescent-Based Assay Reveals That Thrombopoietin Signaling And Bcl-Xl Influence, Respectively, Platelet And Erythrocyte Lifespans
- A Novel Histone Deacetylase Inhibitor, Cg200745, Potentiates Anticancer Effect Of Docetaxel In Prostate Cancer Via Decreasing Mcl-1 And Bcl-Xl
- A Novel Mechanism Of Irinotecan Targeting Mdm2 And Bcl-Xl
- A Novel Myd88 Mutation, L265Rpp, In Waldenström Macroglobulinemia Activates The Nf-Κb Pathway To Upregulate Bcl-Xl Expression And Enhances Cell …
- A Novel Naphthalimide Compound Restores P53 Function In Non-Small Cell Lung Cancer By Reorganizing The Bak· Bcl-Xl Complex And Triggering Transcriptional …
- A Novel Proanthocyanidin Ih636 Grape Seed Extract Increases In Vivo Bcl-Xl Expression And Prevents Acetaminophen-Induced Programmed And Unprogrammed Cell …
- A Novel Pten/Mutant P53/C-Myc/Bcl-Xl Axis Mediates Context-Dependent Oncogenic Effects Of Pten With Implications For Cancer Prognosis And Therapy
- A Novel Role Of Bax, Bak In Cell Cycle Function Of Bcl2 And Bcl-Xl
- A Novel Therapeutic Combination Sequentially Targeting Aurora B And Bcl-Xl In Hepatocellular Carcinoma
- A Phase I Study Of Novel Dual Bcl-2/Bcl-Xl Inhibitor Apg-1252 In Patients With Advanced Small Cell Lung Cancer (Sclc) Or Other Solid Tumor.
- A Physiologic Role Of Bcl-Xl Induced In Activated Macrophages
- A Potent And Highly Efficacious Bcl-2/Bcl-Xl Inhibitor
- A Potent Bh3 Mimetic Targeting Bcl-Xl Induces Apoptosis Regulated By Pten Loss And Integrin Alpha 5 In Prostate Cancer Cells
- A Protein Derived From The Fusion Of Tat Peptide And Fnk, A Bcl‐Xl Derivative, Prevents Cochlear Hair Cell Death From Aminoglycoside Ototoxicity In Vivo
- A Randomized Trial Of Laryngeal Organ Preservation Evaluating Two Cycles Of Induction Chemotherapy With Platinum, Docetaxel, And A Novel Bcl-Xl Inhibitor.
- A Relationship Between 5-Lipoxygenase-Activating Protein And Bcl-Xl Expression In Murine Pro-B Lymphocytic Fl5. 12 Cells
- A Role For Bcl-Xl In Cd1D-Mediated Natural Killer T Cell Responses To B Cells (46.39)
- A Series Of Phytochemicals Prevents Acetaminophen-Induced Programmed And Unprogrammed Cell Deaths By Enhancing Bcl-Xl Expression And Minimizing …
- A Signal Network Involving Coactivated Nf‐Κb And Stat3 And Altered P53 Modulates Bax/Bcl‐Xl Expression And Promotes Cell Survival Of Head And Neck Squamous …
- A Small Inhibitor Of The Interaction Between Bax And Bcl-Xl Can Synergize With Methylprednisolone To Induce Apoptosis In Bcl-Xl-Overexpressing Breast-Cancer Cells
- A Small-Molecule Inhibitor Of Bcl-Xl Potentiates The Activity Of Cytotoxic Drugs In Vitro And In Vivo
- A Synthetic Bcl-Xl Antagonist Induces Apoptosis And Chemosensitization In Malignant Pleural Mesothelioma
- A Three–Dimensional Electron Tomographic Analysis Of Rod Photoreceptor Synaptic Terminal Mitochondria In Control, Lead–Exposed, And/Or Bcl–Xl Transgenic …
- A2A Adenosine Receptor Mediates Hepg2 Cell Apoptosis By Downregulating Bcl‐Xl Expression And Upregulating Bid Expression
- Aav-Mediated Expression Of Bcl-Xl Or Xiap Fails To Induce Neuronal Resistance Against Quinolinic Acid-Induced Striatal Lesioning
- Aberrant Expression Of Tctp Protein Inhibits Cell Apoptosis By Up-Regulating Bcl-Xl In Human Pancreatic Cancer
- Abl-Myc Retroviral Infection Elicits Bone Marrow Plasma Cell Tumors In Bcl-Xl Transgenic Mice
- Absence Of Bcl-Xl Down-Regulation In Response To Cisplatin Is Associated With Chemoresistance In Ovarian Carcinoma Cells
- Abstract B09: Targeting The Anti-Apoptotic Protein Mcl-1 With The Mtor Inhibitor Rad001 Sensitizes Luminal Breast Cancers To The Bcl-2/Bcl-Xl Inhibitor Abt-263
- Abstract B217: Antitumor Activity Of The New Bcl-2/Bcl-Xl Inhibitor S44563 In Primary Human Uveal Melanoma Xenografts.
- Abstract B33: Beyond Apoptosis, Bcl-Xl In Metastasis
- Abstract B42: The Regulation Of The Er-Mitochondria-Ca2+ Cross-Talk By Bcl-2 And Bcl-Xl: A New Scenario For The Development Of Selective Tools In Oncology?
- Abstract C250: Concurrent Targeting Bcl-2/Bcl-Xl And Mdm2 As A New Therapeutic Strategy For Acute Leukemia.
- Abstract C263: Mtor Inhibition Specifically Sensitizes Colorectal Cancers With Kras Or Braf Mutations To Bcl-2/Bcl-Xl Inhibition By Suppressing Mcl-1.
- Abstract P1-09-08: Bcl2L1 (Bcl-Xl) Expression And Myc Super-Enhancer Positivity Predict Sensitivity To The Covalent Cdk7 Inhibitor Sy-1365 In Triple Negative …
- Abstract P4-14-02: Neutralization Of Bcl2/Bcl-Xl Enhances The Cytotoxicity Of T-Dm1 In Vivo
- Abstract Pr09: Synthetic Lethal Interaction Of Combined Bcl-Xl And Mek Inhibition Promotes Tumor Regressions In Kras-Mutant Cancer Models
- Abstract# 1958: Bcl2L12 Contains A Bh3 Like Motif Capable Of Antagonising Bcl-2 And Bcl-Xl And Is Proapoptotic.
- Abstract# 2049: Inhibition Of Notch Enhances Pro-Apoptotic Effect Of Bcl-2/Bcl-Xl Inhibitor In Multiple Myeloma
- Abstract# 3263: Analysis Of The Functional Significance Of Phosphorylation Of Bcl-Xl Induced By Microtubule Inhibitors
- Abstract# 3693: Sorafenib Inhibits Stat3-Regulated Expression Of Prosurvival Mcl-1 And Bcl-Xl Proteins To Enhance Trail-Mediated Apoptosis In Human Pancreatic …
- Abstract# 3865: Cdk1-Mediated Phosphorylation And Inactivation Of Bcl-Xl/Bcl-2: A Functional Link Between Mitotic Arrest And Apoptosis
- Abstract# 3978: Radiation Induced Nitration Of Bcl-2/Bcl-Xl And The Regulation Of Apoptosis
- Abstract# 4100: Impact Of Bcl-Xl Deficiency In Mouse Keratinocytes On Susceptibility To Both Uvb-And Chemically-Induced Skin Carcinogenesis
- Abt-737 Inhibits Full Length And Cleaved Pro-Apoptotic Bcl-Xl, Resulting In Differential Effects On Death And Survival
- Abt-737 Reverses The Acquired Radioresistance Of Breast Cancer Cells By Targeting Bcl-2 And Bcl-Xl
- Abt-737, A Small Molecule Bcl-2/Bcl-Xl Antagonist, Increases Antimitotic-Mediated Apoptosis In Human Prostate Cancer Cells
- Abt-737, A Small Molecule Bcl-2/Bcl-Xl Antagonist, Increases Docetaxel-Mediated Apoptosis In Human Prostate Cancer Cells
- Acetaminophen Induces A Caspase‐Dependent And Bcl‐Xl Sensitive Apoptosis In Human Hepatoma Cells And Lymphocytes
- Acetylation Of The Proto-Oncogene Evi1 Abrogates Bcl-Xl Promoter Binding And Induces Apoptosis
- Acid Destabilization Of The Solution Conformation Of Bcl‐Xl Does Not Drive Its Ph‐Dependent Insertion Into Membranes
- Acidic Preconditioning Increases Expression Of Bcl-Xl And Suppresses
- Acidic Preconditioning Protects Endothelial Cells Against Apoptosis Through P38-And Akt-Dependent Bcl-Xl Overexpression
- Acidic Pre‐Conditioning Suppresses Apoptosis And Increases Expression Of Bcl‐Xl In Coronary Endothelial Cells Under Simulated Ischaemia
- Acquisition Of Resistance To Apoptosis And Necrosis By Bcl‐Xl Over‐Expression In Rat Hepatoma Mca‐Rh8994 Cells
- Activated Grass Carp Stat6 Up-Regulates The Transcriptional Level And Expression Of Ccl20 And Bcl-Xl
- Activated Ras Prevents Downregulation Of Bcl-Xl Triggered By Detachment From The Extracellular Matrix: A Mechanism Of Ras-Induced Resistance To Anoikis In Intestinal …
- Activation Of A Non-Genomic Pim-1/Bad-Pser75 Module Is Required For An Efficient Pro-Survival Effect Of Bcl-Xl Induced By Androgen In Lncap Cells
- Activation Of Caspases Occurs Downstream From Radical Oxygen Species Production, Bcl-Xl Down-Regulation, And Early Cytochrome C Release In Apoptosis Induced By …
- Activation Of Ets-2 By Oxidative Stress Induces Bcl-Xl Expression And Accounts For Glial Survival In Amyotrophic Lateral Sclerosis
- Activation Of Extracellular Signal‐Regulated Kinases Erk1 And Erk2 Induces Bcl‐Xl Up‐Regulation Via Inhibition Of Caspase Activities In Erythropoietin Signaling
- Activation Of Fas By Fasl Induces Apoptosis By A Mechanism That Cannot Be Blocked By Bcl-2 Or Bcl-Xl
- Activation Of Lxrβ Causes Metabolic Reprogramming And Sensitizes Solid Tumors To Bcl-Xl Inhibition Mediated Apoptosis
- Activation Of Lxrβ Inhibits Tumor Respiration And Is Synthetically Lethal With Bcl‐Xl Inhibition
- Activation Of P38 Mapk-Regulated Bcl-Xl Signaling Increases Survival Against Zoledronic Acid-Induced Apoptosis In Osteoclast Precursors
- Activation Of The Cpp32 Apoptotic Protease By Distinct Signaling Pathways With Differential Sensitivity To Bcl-Xl
- Activation Of The P38Mapk Signaling Pathway And Over-Expression Of Bcl-2/Bcl-Xl In Patients With DlBcl: Potential Biomarkers And Targets For Therapeutics. A …
- Activity Induces Apoptosis Of Chronic Myelogenous Leukemia Cells By Suppressing Signal Transducer And Activator Of Transcription 5–Dependent Expression Of Bcl-Xl
- Activity Of A Novel Bcl-2/Bcl-Xl-Bispecific Antisense Oligonucleotide Against Tumors Of Diverse Histologic Origins
- Activity Of Selenium On Cell Proliferation, Cytotoxicity, And Apoptosis And On The Expression Of Casp9, Bcl-Xl And Apc In Intestinal Adenocarcinoma Cells
- Adenosine Activates Ampk To Phosphorylate Bcl-Xl Responsible For Mitochondrial Damage And Diablo Release In Huh-7 Cells
- Adenoviral Transfer Of Mda-7 Leads To Bax Up-Regulation And Apoptosis In Mesothelioma Cells, And Is Abrogated By Over-Expression Of Bcl-Xl
- Adenovirus-Mediated Bcl-Xl Expression Using A Neuron-Specific Synapsin-1 Promoter Protects Against Disseminated Neuronal Injury And Brain Infarction Following …
- Adenovirus-Mediated Bcl-Xl Gene Therapy Combined With Pronase Treatment Protects The Small Intestine From Radiation-Induced Enteritis In Mouse Model
- Adenovirus-Mediated Gene Transfer Of Bcl-Xl Prevents Cell Death In Primary Neuronal Culture Of The Rat
- Adenovirus-Mediated Sirna Targeting Bcl-Xl Inhibits Proliferation, Reduces Invasion And Enhances Radiosensitivity Of Human Colorectal Cancer Cells
- Adenovirus‐Mediated Small Hairpin Rna Targeting Bcl‐Xl As Therapy For Colon Cancer
- Adenovirus-Mediated Transfer Of Bcl-Xl Protects Neuronal Cells From Bax-Induced Apoptosis
- Adipocyte Microenvironment Promotes BclXl Expression And Confers Chemoresistance In Ovarian Cancer Cells
- Advanced Glycation End Products Influence Oral Cancer Cell Survival Via Bcl-Xl And Nrf-2 Regulation In Vitro
- After Embedding In Membranes Antiapoptotic Bcl-Xl Protein Binds Both Bcl-2 Homology Region 3 And Helix 1 Of Proapoptotic Bax Protein To Inhibit Apoptotic …
- Aid-Deficient Bcl-Xl Transgenic Mice Develop Delayed Atypical Plasma Cell Tumors With Unusual Ig/Myc Chromosomal Rearrangements
- Ajuba Overexpression Regulates Mitochondrial Potential And Glucose Uptake Through Yap/Bcl-Xl/Glut1 In Human Gastric Cancer
- Akt And Bcl-Xl Promote Growth Factor-Independent Survival Through Distinct Effects On Mitochondrial Physiology
- Akt1 Drives Endothelial Cell Membrane Asymmetry And Microglial Activation Through Bcl-Xl And Caspase 1, 3, And 9
- Alpha-Tocotrienol Prevents Oxidative Stress-Mediated Post-Translational Cleavage Of Bcl-Xl In Primary Hippocampal Neurons
- Alterations In Eicosanoid Levels During U937 Bcl-Xl Tumour Growth Suppression And Recovery In Nu/Nu Mice In Vivo—Involvement Of Phospholipase A2
- Alterations In The Characteristic Size Distributions Of Subcellular Scatterers At The Onset Of Apoptosis: Effect Of Bcl-Xl And Bax/Bak
- Altered Bad Localization And Interaction Between Bad And Bcl-Xl In The Hippocampus After Transient Global Ischemia
- Amyloid Fibrils Formed By The Programmed Cell Death Regulator Bcl-Xl
- An Il‐2 Receptor Β Subdomain That Controls Bcl‐Xl Expression And Cell Survival
- An Increase In Glucosylceramide Synthase Induces Bcl-Xl-Mediated Cell Survival In Vinorelbine-Resistant Lung Adenocarcinoma Cells
- An Interaction Between Bcl-Xl And The Voltage-Dependent Anion Channel (Vdac) Promotes Mitochondrial Ca2+ Uptake
- An Interaction Between Bcl-Xl And Vdac Facilitates Mitochondrial Ca2+ Uptake And Bioenergetics
- An Oncogenic Tyrosine Kinase Inhibits Dna Repair And Bcl-Xl Deamidation In T Cell Transformation
- An Oncogenic Tyrosine Kinase Inhibits Dna Repair And Dna-Damage-Induced Bcl-Xl Deamidation In T Cell Transformation
- Anacardic Acids From Knema Hookeriana As Modulators Of Bcl-Xl/Bak And Mcl-1/Bid Interactions
- Analysis Of Dynamic Changes In The Proteome Of A Bcl‐Xl Overexpressing Chinese Hamster Ovary Cell Culture During Exponential And Stationary Phases
- Analysis Of Flexibility And Hotspots In Bcl-Xl And Mcl-1 Proteins For The Design Of Selective Small-Molecule Inhibitors
- Analysis Of Intracellular Proapoptotic (Bax, Bak) And Antiapoptotic (Bcl-2, Bcl-Xl) Proteins Expression In Thyrocytes From Young Patients With Immune And Non-Immune …
- Analysis Of Ribosyl-Modified, Mixed Backbone Analogs Of A Bcl-2/Bcl-Xl Antisense Oligonucleotide
- And Cysteamine Supplementation During In Vitro Production Of Buffalo (Bubalus Bubalis) Embryos Affect Mrna Expression Of Bcl‐2, Bcl‐Xl, Mcl‐1, Bax And Bid
- And Low Mitochondrial Membrane Potential Decrease Susceptibility To Apoptosis And Do Not Modulate The Protective Effect Of Bcl-Xl In Osteosarcoma Cells
- Androgen Receptor‐Dependent Regulation Of Bcl‐Xl Expression: Implication In Prostate Cancer Progression
- Angiostatic Effects Of Nk Cell-Derived Ifn-C Counteracted By Tumour Cell Bcl-Xl Expression
- Angiotensin-Ii-Induced Apoptosis Requires Regulation Of Nucleolin And Bcl-Xl By Shp-2 In Primary Lung Endothelial Cells
- Animal Cell-Death Suppressors Bcl-Xl And Ced-9 Inhibit Cell Death In Tobacco Plants
- Antagonist Chlorpromazine And Poly (Adp-Ribose) Polymerase Modulators 4-Aminobenzamide And Nicotinamide Influence Hepatic Expression Of Bcl-Xl And P53 And …
- Antagonistic Effect Of Insulin-Like Growth Factor I On Protein Kinase Inhibitor—Mediated Apoptosis In Human Glioblastoma Cells In Association With Bcl-2 And Bcl-Xl
- Anti-Apoptosis Effect Of Astragaloside Iv On Alzheimer’S Disease Rat Model Via Enhancing The Expression Of Bcl-2 And Bcl-Xl
- Anti-Apoptosis Effect Of Bcl-Xl On Retinal Ganglion Cells By Ultrasound-Mediated Microbubble Destruction
- Anti-Apoptosis Proteins Mcl-1 And Bcl-Xl Have Different P53-Binding Profiles
- Antiapoptotic Bcl-2 And Bcl-Xl In Advanced Malignant Melanoma
- Anti‐Apoptotic Bcl‐Xl Protein In Complex With Bh3 Peptides Of Pro‐Apoptotic Bak, Bad, And Bim Proteins: Comparative Molecular Dynamics Simulations
- Anti-Apoptotic Genes Bcl-2 And Bcl-Xl Overexpression Can Block Iridovirus Serine/Threonine Kinase-Induced Bax/Mitochondria-Mediated Cell Death In Gf-1 Cells
- Antiapoptotic Marker, Bcl-Xl, Expression On Reed-Sternberg Cells Of Hodgkin’S Disease Using A Novel Monoclonal Marker, Yth-2H12
- Anti-Apoptotic Protein Bcl-Xl Expression In The Midbrain Raphe Region Is Sensitive To Stress And Glucocorticoids
- Antiapoptotic Protein Bcl-Xl Is Up-Regulated During Megakaryocytic Differentiation Of Cd34+ Progenitors But Is Absent From Senescent Megakaryocytes
- Antiapoptotic Proteins Bcl-2 And Bcl-Xl Inhibit Clostridium Difficile Toxin A-Induced Cell Death In Human Epithelial Cells
- Anticancer And Chemosensitizing Effects Of 2, 3-Dcpe In Ovarian Carcinoma Cell Lines: Link With Erk Activation And Modulation Of P21Waf1/Cip1, Bcl-2 And Bcl-Xl …
- Anti-Hla Class I Antibody–Mediated Activation Of The Pi3K/Akt Signaling Pathway And Induction Of Bcl-2 And Bcl-Xl Expression In Endothelial Cells
- Anti-Immunoglobulin-Induced Apoptosis In Wehi 231 Cells Involves The Slow Formation Of Ceramide From Sphingomyelin And Is Blocked By Bcl-Xl
- Antisense Activity Of 2′,4′-Bna Targeted To Bcl-Xl Gene In Hepg2 Cell
- Antisense Bcl-Xl Down-Regulation Switches The Response To Topoisomerase I Inhibition From Senescence To Apoptosis In Colorectal Cancer Cells, Enhancing Global …
- Antisense Downregulation Of The Apoptosis-Related Bcl-2 And Bcl-Xl Proteins: A New Approach To Cancer Therapy
- Antisense Oligonucleotide Inhibition Of Bcl-Xl And Bid Expression In Liver Regulates Responses In A Mouse Model Of Fas-Induced Fulminant Hepatitis
- Antisense Oligonucleotides Directed At The Bcl-Xl Gene Product Augment Chemotherapy Response In Mesothelioma
- Antisense Oligonucleotides Targeting Y-Box Binding Protein-1 Inhibit Tumor Angiogenesis By Downregulating Bcl-Xl-Vegfr2/-Tie Axes
- Antisense Rna Down-Regulation Of Bcl-Xl Expression In Prostate Cancer Cells Leads To Diminished Rates Of Cellular Proliferation And Resistance To Cytotoxic …
- Antisense Therapy For Malignant Mesothelioma With Oligonucleotides Targeting The Bcl-Xl Gene Product
- Antisense-And Sirna-Mediated Inhibition Of The Anti-Apoptotic Gene Bcl-Xl For Chemosensitization Of Bladder Cancer Cells
- Anti-Tumor Effect Of Adenovirus-Mediated Bcl-Xl Shrna In Vitro
- Antitumor Evaluation Of The New Bcl‐2/Bcl‐Xl Inhibitor S44563 In Primary Human Uveal Melanoma Xenografts
- Anti-Tumor Pyrimidinylpiperazines Bind To The Prosurvival Bcl-2 Protein Family Member Bcl-Xl
- Apaf-1, Bcl-Xl, Cytochrome C, And Caspase-9 Form The Critical Elements For Cerebral Vascular Protection By Erythropoietin
- Apg-1252-12A Induces Mitochondria-Dependent Apoptosis Through Inhibiting The Antiapoptotic Proteins Bcl-2/Bcl-Xl In Hl-60 Cells
- Apigenin Induces Apoptosis By Suppressing Bcl-Xl And Mcl-1 Simultaneously Via Signal Transducer And Activator Of Transcription 3 Signaling In Colon Cancer
- Apoptosis And Adenocarcinoma Of The Cardia: Expression Of P53, Bcl-2, Bcl-Xl, Waf1, And Fas Proteins And Association With Characteristics Of The Tumors.
- Apoptosis And Expression Of Bcl-2, Bcl-Xl, And Bax In Renal Cell Carcinomas
- Apoptosis And The Conformational Change Of Bax Induced By Proteasomal Inhibition Of Pc12 Cells Are Inhibited By Bcl-Xl And Bcl-2
- Apoptosis Blocks Beclin 1-Dependent Autophagosome Synthesis: An Effect Rescued By Bcl-Xl
- Apoptosis By Gemcitabine In Non-Small Cell Lung Cancer Cell Line Kns62 Is Induced Downstream Of Caspase 8 And Is Profoundly Blocked By Bcl-Xl Over-Expression
- Apoptosis In P53 Protein-Deficient Cells Is Mediated By Bh3-Only Protein-Independent Derepression Of Bak Protein Through Down-Regulation Of Mcl-1 And Bcl-Xl …
- Apoptosis Induced By Ultraviolet B Radiation And Cd95 Ligation–Differential Protection Through Epidermal Growth Factor Receptor Activation And Bcl-Xl …
- Apoptosis Induces Bcl-Xs And Cleaved Bcl-Xl In Chronic Lymphocytic Leukaemia
- Apoptosis Inhibiting Factor Bcl-Xl Might Be The Crucial Member Of The Bcl-2 Gene Family In Colorectal Cancer
- Apoptosis Is Augmented In High-Grade Serous Ovarian Cancer By The Combined Inhibition Of Bcl-2/Bcl-Xl And Parp
- Apoptosis Of Articular Chondrocytes In Osteoarthritis With Degree Of Cartilage Destruction And Expression Of Apoptosis-Related Proteins: Surviving, Caspase-3, And Bcl-Xl
- Apoptosis Of Canine Mammary Tumor Cells Induced By Small Interfering Rna (Sirna) Against Bcl-Xl Gene
- Apoptosis Of Germ Cells And Expressions Of Bcl-Xl And Bad In Rats With Experimental Kidney-Yang Deficiency [J]
- Apoptosis Of Prostate Cancer By Inhibition Of Bcl-Xl Expression
- Apoptosis Protection By The Epo Target Bcl-Xl Allows Factor-Independent Differentiation Of Primary Erythroblasts
- Apoptosis Regulation By Bcl-Xl Modulation Of Mammalian Inositol 1, 4, 5-Trisphosphate Receptor Channel Isoform Gating
- Apoptosis Triggered By Myc-Induced Suppression Of Bcl-Xl Or Bcl-2 Is Bypassed During Lymphomagenesis
- Apoptosis-Modulating Interaction Of The Neuregulin/Erbb Pathway With Antracyclines In Regulating Bcl-Xs And Bcl-Xl In Cardiomyocytes
- Apoptotic Cell Death And Altered Calcium Homeostasis Caused By Frataxin Depletion In Dorsal Root Ganglia Neurons Can Be Prevented By Bh4 Domain Of Bcl-Xl Protein
- Apoptotic Characteristics Of Spleen Lymphocyte In Mice Irradiated By Lethal Dose And Its Relationship To The Expression Of Bax And Bcl-Xl Proteins
- Apoptotic Effect Of Bcl-Xl Antisense Oligodeoxynucleotide Mediated By Lipofectin On Cell Strain Cne-2Z
- Apoptotic Response Of Lung Adenocarcinoma Cells To Pi3K/Akt Inhibition Is Augmented By Bcl-Xl Down-Regulation.
- Apoptotic Responsiveness Of Pc-3 Prostate Cancer Cells To Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand: Evidence For Differential Effects Of Bcl-Xl And Bcl-2 …
- Application Of Combination Of Short Hairpin Rna Segments For Silencing Vegf, Tert, And Bcl-Xl Expression In Laryngeal Squamous Carcinoma
- Aptamer-Targeted Delivery Of Bcl-Xl Shrna Using Alkyl Modified Pamam Dendrimers Into Lung Cancer Cells
- Are Associated With High Apoptotic Index, High Expression Of The Proapoptotic Proteins Bax, Bak And Bid And Low Expression Of The Antiapoptotic Protein Bcl-Xl
- Arf Induces Autophagy By Virtue Of Interaction With Bcl-Xl
- Arginine Antimetabolite L-Canavanine Induces Apoptotic Cell Death In Human Jurkat T Cells Via Caspase-3 Activation Regulated By Bcl-2 Or Bcl-Xl
- Arsenic Trioxide Enhances Sti571-Induced Apoptosis Of K562 Cells Through Downregulating Bcl-Xl And Bcr-Abl.
- Arthritis Patients Express Functional Il-15 Receptor Complex: Endogenous Il-15 In Autocrine Fashion Enhances Cell Proliferation And Expression Of Bcl-Xl And Bcl-2
- Assessing Tumor Progression Factors By Somatic Gene Transfer Into A Mouse Model: Bcl-Xl Promotes Islet Tumor Cell Invasion
- Assessment Of Bcl-2, Bcl-Xl And Mcl-1 In Bone Marrow Biopsy Samples Using Ventana Benchmark Xt Automated Slide Stainer
- Assessment Of Expressions Of Bcl-Xl, B-Fgf, Bmp-2, Caspase-3, Pdgfr-?, Smad1 And Tgf-ß1 Genes In A Rat Model Of Lung Ischemia/Reperfusion
- Assessment Of Expressions Of Bcl-Xl, B-Fgf, Bmp-2, Caspase-3, Pdgfr-Α, Smad1 And Tgf-Β1 Genes In A Rat Model Of Lung Ischemia/Reperfusion
- Association Between Bcl-Xl And 5-Lipoxygenase Activating Protein (Flap) Levels In Il-3-Dependent Fl5. 12 Cells
- Association Between Virulence Factors And Traf1/4-1Bb/Bcl-Xl Expression In Gastric Mucosa Infected With Helicobacter Pylori
- Association Of Bcl-2, Bax, Bcl-Xl And Interleukin-1 Beta-Converting Enzyme Expression With Initial Response To Chemotherapy In Acute Myeloid Leukemia.
- Association Of Cell Growth Modalities In Vitro With Its Heterogenous Expression Of Bcl-Xl In Relapsed Acute Myelogenous Leukemic Cells
- Ataxin-3 Protects Cells Against H2O2-Induced Oxidative Stress By Enhancing The Interaction Between Bcl-Xl And Bax
- Atf3 Repression Of Bcl-Xl Determines Apoptotic Sensitivity To Hdac Inhibitors Across Tumor Types
- Atypical Antipsychotics Attenuate Neurotoxicity Of Β‐Amyloid(25–35) By Modulating Bax And Bcl‐Xl/S Expression And Localization
- Aurora B Inhibitor Tak-901 Synergizes With Bcl-Xl Inhibition By Inducing Active Bax In Cancer Cells
- Autophagy Is Activated, But Is Not Required For The G0 Function Of Bcl-2 Or Bcl-Xl
- Autophagy Protein Lc3 Regulates The Fibrosis Of Hypertrophic Scar By Controlling Bcl-Xl In Dermal Fibroblasts
- Aven And Bcl‐Xl Enhance Protection Against Apoptosis For Mammalian Cells Exposed To Various Culture Conditions
- Aven And Bcl-Xl Expression Pattern And Protein-Protein Interaction Assessment Through Bovine Early Embryo Development
- Aven Blocks Dna Damage-Induced Apoptosis By Stabilising Bcl-Xl
- Aven, A Novel Inhibitor Of Caspase Activation, Binds Bcl-Xl And Apaf-1
- B001: Apoptosis Of Endothelial Cells Leads To Paracrine Induction Of Bcl-Xl In Vascular Smooth Muscle Cells
- Backbone Space In Foldamers Containing Α‐And Β‐Amino Acid Residues: Developing Protease‐Resistant Oligomers That Bind Tightly To The Bh3‐Recognition Cleft Of Bcl‐Xl
- Bad Induces Apoptosis In Cells Over-Expressing Bcl-2 Or Bcl-Xl Without Loss Of Mitochondrial Membrane Potential
- Bad Is A Bh3 Domain-Containing Protein That Forms An Inactivating Dimer With Bcl-Xl.
- Bad Ser-155 Phosphorylation Regulates Bad/Bcl-Xl Interaction And Cell Survival
- Bad, A Heterodimeric Partner For Bcl-Xl And Bcl-2, Displaces Bax And Promotes Cell Death
- Bak Bh3 Peptides Antagonize Bcl-Xl Function And Induce Apoptosis Through Cytochrome C-Independent Activation Of Caspases
- Bax Activation By Engagement With, Then Release From, The Bh3 Binding Site Of Bcl-Xl
- Bax And Bcl-Xl Exert Their Regulation On Different Sites Of The Ceramide Channel
- Bax And Bcl-Xl Expression Are Not Related To Prognosis In Patients With Advanced Esophageal Squamous Cell Carcinoma
- Bax Can Antagonize Bcl-Xl During Etoposide And Cisplatin-Induced Cell Death Independently Of Its Heterodimerization With Bcl-Xl
- Bax Mitochondrial Relocation Is Linked To Its Phosphorylation And Its Interaction With Bcl-Xl
- Bax, Bcl-Xl Exert Their Regulation On Different Sites On The Ceramide Channel
- Bax, But Not Bcl-Xl, Decreases The Lifetime Of Planar Phospholipid Bilayer Membranes At Subnanomolar Concentrations
- Bax/Bcl-Xl Gene Expression Ratio Inversely Correlates With Disease Progression In Chronic Myeloid Leukemia
- Bax-Independent Inhibition Of Apoptosis By Bcl-Xl
- Bax-Induced Caspase Activation And Apoptosis Via Cytochromec Release From Mitochondria Is Inhibitable By Bcl-Xl
- Bcl 2 And Bcl Xl Are Key Determinants Of Resistance To Antitubulin Chemotherapeutics In Melanoma Cells
- Bcl 2 And Bcl-Xl Are Candidate Targets For Growth Inhibition Of Breast Cancer Cells Using Sirna Lipoplexes
- Bcl-2 And Bcl-Xl Antagonize The Mitochondrial Dysfunction Preceding Nuclear Apoptosis Induced By Chemotherapeutic Agents
- Bcl-2 And Bcl-Xl Antisense Oligonucleotides Induce Apoptosis In Melanoma Cells Of Different Clinical Stages
- Bcl-2 And Bcl-Xl Are Important For The Induction Of Paclitaxel Resistance In Human Hepatocellular Carcinoma Cells
- Bcl-2 And Bcl-Xl Are Indispensable For The Late Phase Of Mast Cell Development From Mouse Embryonic Stem Cells
- Bcl-2 And Bcl-Xl Block Apoptosis As Well As Necrosis: Possible Involvement Of Common Mediators In Apoptotic And Necrotic Signal Transduction Pathways.
- Bcl-2 And Bcl-Xl Block Thapsigargin-Induced Nitric Oxide Generation, C-Jun Nh2-Terminal Kinase Activity, And Apoptosis
- Bcl-2 And Bcl-Xl Dual Inhibitor, Abt-737, Circumvents Jnk Mediated Upregulation Of Anti-Apoptotic Molecules In Cisplatin Treated Non-Small Cell Lung Cancer Models
- Bcl-2 And Bcl-Xl Expression Are Down-Regulated In Benign Prostate Hyperplasia Nodules And Not Affected By Finasteride And/Or Celecoxib
- Bcl-2 And Bcl-Xl Inhibit Cd95-Mediated Apoptosis By Preventing Mitochondrial Release Of Smac/Diablo And Subsequent Inactivation Of X-Linked Inhibitor-Of-Apoptosis …
- Bcl-2 And Bcl-Xl Inhibit Fas-Mediated Apoptosis Of Salivary Epithelial Cells
- Bcl-2 And Bcl-Xl Mediate Resistance To Receptor Tyrosine Kinase-Targeted Therapy In Lung And Gastric Cancer.
- Bcl-2 And Bcl-Xl Overexpression Inhibits Cytochrome C Release, Activation Of Multiple Caspases, And Virus Release Following Coxsackievirus B3 Infection
- Bcl‐2 And Bcl‐Xl Play Important Roles In The Crosstalk Between Autophagy And Apoptosis
- Bcl-2 And Bcl-Xl Regulate Proinflammatory Caspase-1 Activation By Interaction With Nalp1
- Bcl-2 And Bcl-Xl Restrict Lineage Choice During Hematopoietic Differentiation
- Bcl-2 And Bcl-Xl Suppress Glucose Signaling In Pancreatic Β-Cells
- Bcl-2 Gene And Its Family Genes Bax, Bcl-Xl As Well As Fas/Apo-1 And Their Clinical Significance In Acute Leukemia.
- Bcl-2 Is A Better Abt-737 Target Than Bcl-Xl Or Bcl-W And Only Noxa Overcomes Resistance Mediated By Mcl-1, Bfl-1, Or Bcl-B
- Bcl-2 Or Bcl-Xl Gene Therapy Increases Neural Plasticity Proteins Nestin And C-Fos Expression In Pc12 Cells
- Bcl-2 Or Bcl-Xl Gene Therapy Reduces Apoptosis And Increases Plasticity Protein Gap-43 In Pc12 Cells
- Bcl-2 Or Bcl-Xl Overexpression Stimulates Both Oxidative And Fermentative Components Of Carbohydrate Metabolism
- Bcl-2 Or Bcl-Xl Overexpression Stimulates Lactic Fermentation Without Affecting Whole Cell Respiration
- Bcl-2 Or Bcl-Xl Overexpresssion Affects Both Lactic Fermentation And Mitochondrial Metabolism In Growing Pro-Lymphocytes
- Bcl-2, Bax And Bcl-Xl Expression In Human Sensitive And Resistant Leukemia Cell Lines
- Bcl-2, Bax, Bcl-Xl And Bcl-Xs Expression In Neoplastic And Normal Cervical Tissue
- Bcl-2, Bax, Bcl-Xl And Bcl-Xs Expression In Neoplastic And Normal Endometrium
- Bcl-2, Bax, Bcl-Xl, And Bcl-X Expression In Normal And Neoplastic Ovarian Tissues’
- Bcl-2, Bax, Bcl-Xl, And Bcl-Xs Expression In Normal And Neoplastic Ovarian Tissues.
- Bcl-2, Bax, Bcl-Xs, Bcl-Xl Expression And Significant Of Myocardium In Heart Failure Rats [J]
- Bcl-2, Bcl-Xl And C-Flipl Potentially Regulate The Susceptibility Of Human Peripheral Blood Monocyte-Derived Dendritic Cells To Cell Death At Different Developmental …
- Bcl-2, Bcl-Xl Sequester Bh3 Domain-Only Molecules Preventing Bax-And Bak-Mediated Mitochondrial Apoptosis
- Bcl-2, Bcl-Xl, And P-Akt Are Involved In Neuroprotective Effects Of Transcription Factor Brn3B In An Ocular Hypertension Rat Model Of Glaucoma
- Bcl-2, Bcl-Xl, And Pp32/Phapi In Resected Non-Small-Cell Lung Cancer Patients.
- Bcl-2/Bcl-Xl Bispecific Antisense Treatment Sensitizes Breast Carcinoma Cells To Doxorubicin, Paclitaxel And Cyclophosphamide
- Bcl-2/Bcl-Xl Inhibition Increases The Efficacy Of Mek Inhibition Alone And In Combination With Pi3 Kinase Inhibition In Lung And Pancreatic Tumor Models
- Bcl‐2/Bcl‐Xl Inhibition Predominantly Synergistically Enhances The Anti‐Neoplastic Activity Of A Low‐Dose Cusp9 Repurposed Drug Regime Against Glioblastoma
- Bcl‑2/Bcl‑Xl Inhibitor Abt‑737 Sensitizes Pancreatic Ductal Adenocarcinoma To Paclitaxel‑Induced Cell Death
- Bcl2/Bcl-Xl Inhibitor Engenders Apoptosis And Increases Chemo-Sensitivity In Mesothelioma
- Bcl-2/Bcl-Xl Mediate Ros Production In Pancreatic Cancer Cells Leading To The Inhibition Of Apoptosis
- Bcl-2/Bcl-Xl Regulates Cell Cycle Through A Novel Mechanism In Addition To Cell Survival
- Bcl-Xl Acts Downstream Of Caspase-8 Activation By The Cd95 Death-Inducing Signaling Complex
- Bcl-Xl Affects Ca2+ Homeostasis By Altering Expression Of Inositol 1, 4, 5-Trisphosphate Receptors
- Bcl-Xl Affects Group A Streptococcus-Induced Autophagy Directly, By Inhibiting Fusion Between Autophagosomes And Lysosomes, And Indirectly, By Inhibiting …
- Bcl-Xl Affects The Development Of Functional Cd4 Tregs
- Bcl-Xl And Bak Protein Expression In Human Optic Nerve Axons In Eyeballs Post-Trauma And In The Eyes With Absolute Glaucoma.
- Bcl-Xl And Bcl-2 Expression In Bilharzial Squamous Cell Carcinoma Of The Urinary Bladder: Which Protein Is Prognostic?
- Bcl‐Xl And Bcl‐2 Expression In Squamous Cell Carcinoma Of The Head And Neck
- Bcl-Xl And Bcl-2 Proteins In Melanoma Progression And Uvb-Induced Apoptosis
- Bcl-Xl And Bcl-2 Repress A Common Pathway Of Cell Death.
- Bcl-Xl And Calyculin A Prevent Translocation Of Bax To Mitochondria During Apoptosis
- Bcl-Xl And Caspase Inhibition Increase The Survival Of Rat Oxytocin And Vasopressin Magnocellular Neurons In Organotypic Culture
- Bcl-Xl And E1B-19K Proteins Inhibit P53-Induced Irreversible Growth Arrest And Senescence By Preventing Reactive Oxygen Species-Dependent P38 Activation
- Bcl-Xl And Il-6 Act Independently And Synergistically To Accelerate Plasmacytopoiesis And Plasma Cell Tumor Formation In Balb/C Mice.
- Bcl-Xl And Mcl-1 Are Involved In Prevention Of In Vitro Apoptosis In Rat Late-Stage Erythroblasts Derived From Bone Marrow
- Bcl-Xl And Mcl-1 Are The Key Bcl-2 Family Proteins In Melanoma Cell Survival
- Bcl-Xl And Mcl-1 Are The Major Determinants Of The Apoptotic Response To Dual Pi3K And Mek Blockage
- Bcl‐Xl And Mcl‐1 Constitute Pertinent Targets In Ovarian Carcinoma And Their Concomitant Inhibition Is Sufficient To Induce Apoptosis
- Bcl-Xl And Mcl-1 Upregulation By Calreticulin Promotes Apoptosis Resistance Of Fibroblast-Like Synoviocytes Via Activation Of Pi3K/Akt And Stat3 Pathways In …
- Bcl-Xl And Myeloid Cell Leukaemia-1 Contribute To Apoptosis Resistance Of Colorectal Cancer Cells
- Bcl‐Xl And Stat3 Mediate Malignant Actions Of Γ‐Irradiation In Lung Cancer Cells
- Bcl-Xl And Uvrag Cause A Monomer-Dimer Switch In Beclin1
- Bcl-Xl Anti-Apoptotic Network Is Dispensable For Development And Maintenance Of Cml But Is Required For Disease Progression Where It Represents A New Therapeutic …
- Bcl-Xl Anti-Apoptotic Network Is Dispensable For Emergence And Maintenance Of Cml But Required For Disease Progression, And Represents An Alternative Target For …
- Bcl-Xl Antisense Oligodeoxynucleotide Sensitizes Human Esophageal Cancer Cell Line To 5-Fluorouracil
- Bcl‐Xl Antisense Oligonucleotide And Cisplatin Combination Therapy Extends Survival In Scid Mice With Established Mesothelioma Xenografts
- Bcl-Xl Antisense Oligonucleotides Chemosensitize Human Glioblastoma Cells
- Bcl-Xl Antisense Oligonucleotides Coupled With Antennapedia Enhances Radiation-Induced Apoptosis In Pancreatic Cancer
- Bcl‐Xl Antisense Oligonucleotides Induce Apoptosis And Increase Sensitivity Of Pancreatic Cancer Cells To Gemcitabine
- Bcl‐Xl Antisense Sensitizes Human Colon Cancer Cell Line To 5‐Fluorouracil
- Bcl‐Xl Antisense Treatment Induces Apoptosis In Breast Carcinoma Cells
- Bcl-Xl Antisense Treatment Sensitizes Bcl-Xl-Overexpressing Squamous Cell Carcinoma Cells To Carboplatin
- Bcl-Xl As A Critical Apoptosis Antagonist In Hepatocytes And Hepatocellular Carcinoma
- Bcl‐Xl As A Fusion Protein For The High‐Level Expression Of Membrane‐Associated Proteins
- Bcl-Xl As A Poor Prognostic Biomarker And Predictor Of Response To Adjuvant Chemotherapy Specifically In Braf-Mutant Stage Ii And Iii Colon Cancer
- Bcl-Xl As A Poor Prognostic Biomarker And Predictor Of Response To Adjuvant Chemotherapy Specifically In-Mutant Stage Ii And Iii Colon Cancer
- Bcl-Xl As A Radiosensitizer In The Treatment Of Group C Medulloblastoma
- Bcl-Xl As An Antiapoptotic Molecule For Cardiomyocytes.
- Bcl-Xl As The Most Promising Bcl-2 Family Member In Targeted Treatment Of Chondrosarcoma
- Bcl-Xl Blocks A Mitochondrial Inner Membrane Channel And Prevents Ca2+ Overload-Mediated Cell Death
- Bcl-Xl Blocks Activation Of Related Adhesion Focal Tyrosine Kinase/Proline-Rich Tyrosine Kinase 2 And Stress-Activated Protein Kinase/C-Jun N-Terminal Protein Kinase In …
- Bcl-Xl Blocks High Dose Doxorubicin-Induced Apoptosis But Not Low Dose Doxorubicin-Induced Cell Death Through Mitotic Catastrophe
- Bcl‐Xl Blocks Mitochondrial Multiple Conductance Channel Activation And Inhibits 6‐Ohda‐Induced Death In Sh‐Sy5Y Cells
- Bcl-Xl Blocks Transforming Growth Factor-Β1-Induced Apoptosis By Inhibiting Cytochrome C Release And Not By Directly Antagonizing Apaf-1-Dependent Caspase …
- Bcl-Xl Blocks Tumor Necrosis Factor Alpha-Induced Caspase 8 Activation And Apoptosis
- Bcl-Xl Can Inhibit Apoptosis In Cells That Have Undergone Fas-Induced Protease Activation
- Bcl-Xl Confers Multi-Drug Resistance In Several Squamous Cell Carcinoma Cell Lines
- Bcl-Xl Conformational Changes Upon Fragment Binding Revealed By Nmr
- Bcl-Xl Controls A Switch Between Cell Death Modes During Mitotic Arrest
- Bcl-Xl Cooperatively Associates With The Bap31 Complex In The Endoplasmic Reticulum, Dependent On Procaspase-8 And Ced-4 Adaptor
- Bcl-Xl Deamidation A Trigger For Apoptosis
- Bcl-Xl Deamidation And Cancer: Charting The Fame Trajectories Of Legitimate Child And Hidden Siblings
- Bcl-Xl Deamidation In Oncogenic Tyrosine Kinase Signalling
- Bcl-Xl Deamidation Is A Critical Switch In The Regulation Of The Response To Dna Damage
- Bcl-Xl Deamidation Is Regulated By Multiple Ion Transporters And Is Intramolecularly Catalyzed
- Bcl-Xl Deamidation: Its Consequences And Regulation
- Bcl-Xl Dependence Predicts Response To Alvocidib In Chronic Lymphocytic Leukemia Patients
- Bcl-Xl Dependency Coincides With The Onset Of Neurogenesis In The Developing Mammalian Spinal Cord
- Bcl-Xl Depletion Promotes Apoptosis And Retards Growth Of Pancreatic Cancer Tumor Xenografts
- Bcl-Xl Destabilization Of Ceramide Channels: Role Of The Hydrophobic Groove
- Bcl-Xl Determines The Metabolic Efficiency Of Neurons, Through Interaction With Mitochondrial Atp Synthase
- Bcl-Xl Dimerization By Three-Dimensional Domain Swapping
- Bcl-Xl Directly Modulates Ras Signalling To Favour Cancer Cell Stemness
- Bcl-Xl Directly Retrotranslocates The Monomeric Bak
- Bcl-Xl Displays Restricted Distribution During T Cell Development And Inhibits Multiple Forms Of Apoptosis But Not Clonal Deletion In Transgenic Mice.
- Bcl-Xl Disrupts Death-Inducing Signal Complex Formation In Plasma Membrane Induced By Hypoxia/Reoxygenation
- Bcl-Xl Does Not Have To Bind Bax To Protect T Cells From Death
- Bcl-Xl Downregulation Using Short Hairpin Rna (Shrna) Sensitises Hct-116 Colon Cancer Cells To Topoisomerase I Inhibition
- Bcl-Xl Dynamics And Cancer-Associated Mutations Under The Lens Of Protein Structure Networks And Biomolecular Simulations
- Bcl-Xl Enhances Single-Cell Survival And Expansion Of Human Embryonic Stem Cells Without Affecting Self-Renewal
- Bcl-Xl Expression After Contusion To The Rat Spinal Cord
- Bcl-Xl Expression And Cisplatin Resistance In Head And Neck Squamous Cell Carcinoma Cells
- Bcl-Xl Expression And Its Relationships With Clinical Pathological Characteristics, Expression Of Estrogen And Progestogen Receptors In Breast Cancer
- Bcl-Xl Expression And Mutation In Non-Hodgkin’S Lymphoma
- Bcl-Xl Expression Correlates With Primary Macrophage Differentiation, Activation Of Functional Competence, And Survival And Results From Synergistic Transcriptional …
- Bcl-Xl Expression Improves The Therapeutic Effect Of Human Umbilical Cord Stem Cell Transplantation On Articular Cartilage Injury In Rabbit
- Bcl-Xl Expression In Multiple Myeloma
- Bcl‐Xl Expression In Stem Cells Facilitates Engraftment And Reduces The Need For Host Conditioning During Bone Marrow Transplantation
- Bcl‐Xl Expression Interferes With The Effects Of L‐Glutamine Supplementation On Hybridoma Cultures
- Bcl-Xl Expression Is Druggable Biomarker Associated With A Poor Clinical Outcome In Relapsed/Refractory Diffuse Large B-Cell Lymphoma (DlBcl)
- Bcl-Xl Expression Is Essential For Human Erythropoiesis And Engraftment Of Hematopoietic Stem Cells
- Bcl-Xl Expression Levels Influence Differential Regional Astrocytic Susceptibility To 1, 3-Dinitrobenzene
- Bcl-Xl Forms An Ion Channel In Synthetic Lipid Membranes
- Bcl-Xl Forms Two Distinct Homodimers At Non-Ionic Detergents: Implications In The Dimerization Of Bcl-2 Family Proteins
- Bcl-Xl Functions Downstream Of Caspase-8 To Inhibit Fas-And Tumor Necrosis Factor Receptor 1-Induced Apoptosis Of Mcf7 Breast Carcinoma Cells
- Bcl-Xl Gain Of Function And P19Arf Loss Of Function Cooperate Oncogenically With Myc In Vivo By Distinct Mechanisms
- Bcl-Xl Gene Expression Correlated With Lower Apoptotic Cell Numbers And Shorter Progression-Free Survival In Pcfcl
- Bcl-Xl Gene Transfer Inhibits Bax Translocation And Prolongs Cardiac Cold Preservation Time In Rats
- Bcl-Xl Gene Transfer Protects The Heart Against Ischemia/Reperfusion Injury
- Bcl-Xl Genetic Modification Enhanced The Therapeutic Efficacy Of Mesenchymal Stem Cell Transplantation In The Treatment Of Heart Infarction
- Bcl-Xl In Neuroprotection And Plasticity
- Bcl-Xl In Prostate Cancer Cells: Effects Of Overexpression And Down-Regulation On Chemosensitivity
- Bcl-Xl Increases Axonal Numbers But Not Axonal Elongation From Rat Retinal Explants
- Bcl-Xl Increases Bax Mitochondrial Localization And Activation In Non-Apoptotic Cells
- Bcl-Xl Increases Mitochondrial Fission, Fusion, And Biomass In Neurons
- Bcl-Xl Induces Drp1-Dependent Synapse Formation In Cultured Hippocampal Neurons
- Bcl-Xl Inhibition By Molecular-Targeting Drugs Sensitizes Human Pancreatic Cancer Cells To Trail
- Bcl-Xl Inhibition Enhances Dinaciclib-Induced Cell Death In Soft-Tissue Sarcomas.