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    PREMATURE SENESCENCE
    January 7, 2020
    Oncogene Activation
    January 8, 2020

    JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age

    A hallmark of aging is chronic sterile inflammation, which is closely associated with frailty and age-related diseases. We found that senescent fat progenitor cells accumulate in adipose tissue with aging and acquire a senescence-associated secretory phenotype (SASP), with increased production of proinflammatory cytokines compared with nonsenescent cells. These cells provoked inflammation in adipose tissue and induced macrophage migration. The JAK pathway is activated in adipose tissue with aging, and the SASP can be suppressed by inhibiting the JAK pathway in senescent cells. JAK1/2 inhibitors reduced inflammation and alleviated frailty in aged mice. One possible mechanism contributing to reduced frailty is SASP inhibition. Our study points to the JAK pathway as a potential target for countering age-related dysfunction.

    A hallmark of aging is chronic, low-grade, “sterile” inflammation (1–3). Elevated proinflammatory cytokines and chemokines are closely associated with mortality (4, 5) and with a variety of age-related diseases, including atherosclerosis (6), depression (7), cancers (8), diabetes (9), and neurodegenerative diseases (10, 11). Inflammation also is associated with frailty, a geriatric syndrome characterized by decreased strength and incapacity to respond to stress (2).

    The underlying mechanisms of age-related chronic inflammation, tissue dysfunction, and frailty remain elusive. Cellular senescence, stable arrest of cell growth in replication-competent cells, is a plausible contributor. Senescence can be induced by a number of stimuli and stresses, including telomere dysfunction, genomic instability, oncogenic and metabolic insults, and epigenetic changes (12). Senescent cells accumulate with aging in the skin (13, 14), liver (15, 16), kidney (17), the cardiovascular system (18), and other tissues in various species (16). The senescence-associated secretory phenotype (SASP), largely comprised of proinflammatory cytokines and chemokines (19, 20), links senescent cells to age-related inflammation and diseases. We found that elimination of senescent cells delayed the onset of age-related phenotypes and enhanced healthspan (21, 22). Therefore, senescent cells and the SASP could play a role in age-related pathologies, particularly those that involve systemic inflammation.

    The JAK/STAT pathway plays an important role in regulating cytokine production (23, 24). We hypothesized that it may directly affect the SASP. The JAK family has four members: JAK1, JAK2, JAK3, and tyrosine kinase 2 (TYK2). JAK1 and 2 are involved in inflammatory signaling and in the action of growth hormone and other endocrine and paracrine signals (25). JAK3 is expressed primarily in blood cells and mediates erythropoietin signaling and immune cell generation (26–29). TYK2 plays an important role in white blood cell function and host defenses (30, 31). A number of inhibitors that target different JAKs have been approved or are in phase I–III studies for treating myelofibrosis (23, 32–34), acute myeloid leukemia (23), lymphoma (23), and rheumatoid arthritis (23, 35, 36). JAK inhibitors recently have been found to reprogram the SASP in senescent tumor cells, contributing to improved antitumor response (37). Therefore, we investigated the role of the JAK pathway in age-related inflammation and dysfunction.

    We demonstrate here that senescent preadipocytes, fat cell progenitors, accumulate in adipose tissue with aging and can contribute to adipose tissue inflammation. We found that JAK inhibitors decrease the SASP in preadipocytes and human umbilical vein endothelial cells (HUVECs). They also decrease age-related adipose tissue and systemic inflammation as well as frailty. Our findings provide insights into the possible contribution of senescent cells to age-related inflammation and, in turn, to age-related pathologies, as well as potential therapeutic targets to alleviate age-related dysfunction.

    SCIENTIFIC STUDIES

     

    1. The effect of JAK inhibition on neutrophil killing, netosis and metabolism in rheumatoid arthritis
    2. JAK Inhibition by Tofacitinib Improves Rheumatoid Cachexia in a Rabbit Experimental Model That Reproduces the Lipid Paradox in Humans
    3.  JAK-inhibition with peficitinib and filgotinib in fibroblast-like synoviocytes in rheumatoid arthritis
    4. Combined MEK and JAK inhibition rescues mutant hematopoietic stem cell function and provides long-term survival in NrasG12D/G12D mice
    5. gp130/Jak/Stat3 inhibition blocks WNT signaling-mediated intestinal tumorigenesis and regeneration
    6. Effects of JAK pathway inhibition in pre-clinical models of breast cancer bone marrow metastases
    7. Repurposing Jak/Stat Signaling Inhibition to Enhance Costimulation Blockade and Promote Transplant Acceptance
    8. Resistance to tyrosine kinase inhibitors reversed by selective JAK inhibition
    9. Activating JAK1 mutation may predict the sensitivity of JAK-STAT inhibition in hepatocellular carcinoma
    10. Alopecia areata is driven by cytotoxic T lymphocytes and is reversed by JAK inhibition
    11. Alternatively spliced, truncated GCSF receptor promotes leukemogenic properties and sensitivity to JAK inhibition
    12. Anti-myeloma effects of ruxolitinib combined with bortezomib and lenalidomide: A rationale for Jak/Stat pathway inhibition in myeloma patients
    13. Arsenic inhibition of the JAK-STAT pathway
    14. Assessing efficacy in myelofibrosis treatment: a focus on JAK inhibition
    15. Baricitinib: JAK inhibition for rheumatoid arthritis.
    16. Benefits and risks of JAK inhibition
    17. BET’ing on Dual JAK/BET Inhibition as a Therapeutic Strategy for Myeloproliferative Neoplasms
    18. Blockade of PDGFRβ circumvents resistance to MEK-JAK inhibition via intratumoral CD8+ T-cells infiltration in triple-negative breast cancer
    19. C34 NEW BASIC SCIENCE IN ASTHMA: Effect Of Janus Kinase (jak) Inhibition On Thymic Stromal Lymphopoietin (tslp) Response In Monocyte Derived Dendritic …
    20. Combined MEK and JAK inhibition abrogates murine myeloproliferative neoplasm
    21. Compositions and methods for inhibition of the JAK pathway
    22. Danzhi Jiangtang Capsule ameliorates kidney injury via inhibition of the JAK-STAT signaling pathway and increased antioxidant capacity in STZ-induced diabetic …
    23. Decreased NK-cell tumour immunosurveillance consequent to JAK inhibition enhances metastasis in breast cancer models
    24. Discovery of a JAK3-selective inhibitor: functional differentiation of JAK3-selective inhibition over pan-JAK or JAK1-selective inhibition
    25. Dual SYK/JAK inhibition overcomes ibrutinib resistance in chronic lymphocytic leukemia: cerdulatinib, but not ibrutinib, induces apoptosis of tumor cells …
    26. Effect Of Janus Kinase (jak) Inhibition On Thymic Stromal Lymphopoietin (tslp) Response In Monocyte Derived Dendritic Cells (mddcs)
    27. Efficacy of JAK 1/2 inhibition in the treatment of diffuse non-scarring alopecia due to systemic lupus erythematosus
    28. Efficacy of selective JAK inhibition in models of leukemia, lymphoma, myeloma, and JAK2V617F dependent malignancy
    29. Evaluation of JAK inhibition with topical tofacitinib in an experimental autoimmune uveitis model (EAU)
    30. Ex vivo inhibition of JAK and IKK preserves cartilage formation in catabolically stimulated bovine articular cartilage
    31. How we manage JAK inhibition in allogeneic transplantation for myelofibrosis
    32. Hsp90 inhibition disrupts JAK-STAT signaling and leads to reductions in splenomegaly in patients with myeloproliferative neoplasms
    33. Immunological consequences of JAK inhibition: friend or foe?
    34. Improved efficacy of allergen-specific immunotherapy by JAK inhibition in a murine model of allergic asthma
    35. Improved JAK inhibition in myelofibrosis—the long road ahead
    36. Improvement of spontaneous locomotor activity with JAK inhibition by JTE-052 in rat adjuvant-induced arthritis
    37. In vitro JAK kinase activity and inhibition assays
    38. Inhibition of IL-6/Jak/Stat3 signaling: a novel and potent targeting therapy for lung cancer
    39. Inhibition of JAK kinases in patients with rheumatoid arthritis: scientific rationale and clinical outcomes
    40. Inhibition of Jak/Stat pathway restrains TSLP-activated dendritic cells mediated inflammatory T helper type 2 cell response in allergic rhinitis
    41. Inhibition of Jak/Stat signaling in rheumatologic disorders: The expanding spectrum
    42. Inhibition of Jak/Stat signaling reduces the activation of pancreatic stellate cells in vitro and limits caerulein-induced chronic pancreatitis in vivo
    43. Inhibition of Jak/Stat Signaling Synergizes with CTLA4-Ig to Promote Transplant Survival
    44. JAK inhibition in STING-associated interferonopathy
    45. Inhibition of Janus kinase/signal transducer and activator of transcription (Jak/Stat) signalling pathway in rheumatoid synovial fibroblasts using small molecule …
    46. Inhibition of related Jak/Stat pathways with molecular targeted drugs shows strong synergy with ruxolitinib in chronic myeloproliferative neoplasm
    47. Inhibition of TAK1 and/or JAK can rescue impaired chondrogenic differentiation of human mesenchymal stem cells in osteoarthritis-like conditions
    48. Inhibition of the Jak/Stat pathway protects against α-synuclein-induced neuroinflammation and dopaminergic neurodegeneration
    49. JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age
    50. JAK inhibition and modulation of T cell function
    51. JAK inhibition and progressive kidney disease
    52. JAK inhibition as a therapeutic strategy for immune and inflammatory diseases
    53. JAK inhibition blocks rna interference associated toxicities
    54. JAK inhibition by methotrexate (and csDMARDs) may explain clinical efficacy as monotherapy and combination therapy
    55. JAK inhibition for the treatment of rheumatoid arthritis: a new era in oral DMARD therapy
    56. JAK inhibition impairs NK cell function in myeloproliferative neoplasms
    57. JAK inhibition in inflammatory bowel disease
    58. JAK-inhibition-myelofibrosis/22/00006024″>JAK inhibition in myelofibrosis
    59. JAK inhibition in rheumatoid arthritis
    60. JAK inhibition in the myeloproliferative neoplasms: lessons learned from the bench and bedside
    61. JAK inhibition in the treatment of alopecia areata–a promising new dawn?
    62. JAK inhibition in the treatment of diabetic kidney disease
    63. JAK Inhibition Induces Browning of White Adipocytes
    64. JAK inhibition induces silencing of T Helper cytokine secretion and a profound reduction in T regulatory cells
    65. JAK inhibition reverses IL10-mediated resistance to B cell receptor (BCR) pathway inhibition in DLBCL
    66. JAK inhibition using tofacitinib for inflammatory bowel disease treatment: a hub for multiple inflammatory cytokines
    67. JAK inhibition with ruxolitinib as pretreatment for allogeneic stem cell transplantation in primary or post-ET/PV myelofibrosis
    68. JAK inhibition with ruxolitinib versus best available therapy for myelofibrosis
    69. JAK inhibition with tofacitinib curbs RANKL-induced joint damage
    70. JAK inhibition with tofacitinib suppresses arthritic joint structural damage through decreased RANKL production
    71. JAK inhibition, but not Stat1 knockdown, blocks the synergistic effect of IFN-γ on Fas-induced apoptosis of A549 human non-small cell lung cancer cells
    72. JAK-inhibition-a-new-therapeutic-strategy-for-management-of-chronic-diseases-2167-7956-1000e148.pdf”>JAK Inhibition: A new therapeutic strategy for management of chronic diseases
    73. JAK inhibition: the key to treating myeloproliferative neoplasm?
    74. JAK Inhibition: The Most Promising Agents in the IBD Pipeline?
    75. JAK kinase inhibition abrogates STAT3 activation and head and neck squamous cell carcinoma tumor growth
    76. JAK Stat signaling and cancer: Opportunities, benefits and side effects of targeted inhibition
    77. Jak/Stat inhibition in macrophages promotes therapeutic resistance by inducing expression of protumorigenic factors
    78. Jak/Stat pathway inhibition overcomes IL7-induced glucocorticoid resistance in a subset of human T-cell acute lymphoblastic leukemias
    79. JAK‐1 Inhibition Suppresses Interferon‐Induced BAFF Production in Human Salivary Gland: Potential Therapeutic Strategy for Primary Sjögren’s Syndrome
    80. JAK-2 Inhibition: Current Roles in Myelofibrosis and Initial Lessons Learned from Mexico
    81. JAK-INHIBITION WITH RUXOLITINIB IN PATIENTS WITH RELAPSED OR REFRACTORY CLASSICAL HODGKIN LYMPHOMA: A PHASE II, OPEN LABEL …
    82. JAK‐STAT inhibition impairs K‐RAS‐driven lung adenocarcinoma progression
    83. Management of myelofibrosis: JAK inhibition and beyond
    84. NK cell modulation by JAK inhibition
    85. OP0155 Development of A JAK3 Specific Inhibitor Clinical Candidate: Functional Differentiation of JAK3 Selective Inhibition over PAN-JAK or JAK1 Selective Inhibition
    86. Overcoming acquired resistance to HSP90 inhibition by targeting JAK-STAT signalling in triple-negative breast cancer
    87. P148 JAK-inhibition by baricitinib and tofacitinib ameliorates pathological bone loss
    88. Partial inhibition of gp130-JAK-Stat3 signaling prevents Wnt–β-catenin–mediated intestinal tumor growth and regeneration
    89. Pathogenic and therapeutic relevance of Jak/Stat signaling in systemic lupus erythematosus: integration of distinct inflammatory pathways and the prospect of their …
    90. Pharmacologic inhibition of JAK-STAT signaling promotes hair growth
    91. RAF associates with phosphorylated nuclear BubR1 during endoreduplication induced by JAK inhibition
    92. Response to:’JAK inhibition in STING-associated interferonopathy’by Crow et al
    93. Selective functional inhibition of JAK‐3 is sufficient for efficacy in collagen‐induced arthritis in mice
    94. Selective JAK inhibition for AS
    95. Selective JAK inhibition proves efficacious in epithelial cancer models
    96. Selective Jak/Stat Inhibition: Signaling a Way Forward in the Management of Myelofibrosis.
    97. Signal inhibition reveals Jak/Stat3 pathway as critical for bovine inner cell mass development
    98. Simultaneous inhibition of JAK and SYK kinases ameliorates chronic and destructive arthritis in mice
    99. SOCS3 binds specific receptor–JAK complexes to control cytokine signaling by direct kinase inhibition
    100. SP0169 JAK inhibition in patients with rheumatoid arthritis
    101. Specificity of JAK-kinase inhibition determines impact on human and murine T-cell function
    102. Sustained src inhibition results in STAT3 activation and cancer cell survival via altered JAK-STAT3 binding
    103. The colony-stimulating factor 3 receptor T640N mutation is oncogenic, sensitive to JAK inhibition, and mimics T618I
    104. The future of JAK inhibition in myelofibrosis and beyond
    105. The JAK inhibitor ruxolitinib impairs dendritic cell migration via off-target inhibition of ROCK
    106. The JAK inhibitor tofacitinib regulates synovitis through inhibition of interferon‐γ and interleukin‐17 production by human CD4+ T cells
    107. The molecular basis of Jak/Stat inhibition by SOCS1
    108. Therapeutic inhibition of JAK activity inhibits progression of gastrointestinal tumors in mice
    109. THU0040 Enhancement of early human b cell development by JAK inhibition
    110. THU0044 Simultaneous Inhibition of JAK and Syk Kinases Ameliorates Chronic, Severe and Destructive Arthritis in Mice
    111. Type I interferon signature predicts response to JAK inhibition in haploinsufficiency of A20
    112. Varicella Zoster Infection Associated with Pharmacological JAK-STAT Inhibition via Ruxolitinib in Myeloproliferative Diseases
    113. White-to-brown metabolic conversion of human adipocytes by JAK inhibition
    114. 064 Early experience with JAK inhibitor prescribing in the UK: results from the British Society for Rheumatology Biologics Register for Rheumatoid Arthritis (BSRBR …
    115. 233: The Prevention of Acute Rejection with a Novel JAK Inhibitor
    116. 3-Amido pyrrolopyrazine JAK kinase inhibitors: development of a JAK3 vs JAK1 selective inhibitor and evaluation in cellular and in vivo models
    117. 3-O-methylthespesilactam, a new small-molecule anticancer pan-JAK inhibitor against A2058 human melanoma cells
    118. A Macromolecular Janus Kinase (JAK) Inhibitor Prodrug Effectively Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice
    119. A new player in psoriatic arthritis: a JAK inhibitor
    120. A novel JAK inhibitor JTE‐052 reduces skin inflammation and ameliorates chronic dermatitis in rodent models: Comparison with conventional therapeutic agents
    121. A novel JAK inhibitor, peficitinib, demonstrates potent efficacy in a rat adjuvant-induced arthritis model
    122. A novel JAK-STAT inhibitor, 2-[(3-Carbamoyl-2-thienyl) amino]-2-oxoethyl (2, 6-dichlorophenyl) acetate, suppresses helper T cell differentiation in vitro and collagen …
    123. A Phase 2 Study of the Dual SYK/JAK Inhibitor Cerdulatinib Demonstrates Good Tolerability and Clinical Response in Relapsed/Refractory Peripheral T-Cell …
    124. A phase I/II study of INCB018424, an oral, selective JAK inhibitor, in patients with primary myelofibrosis (PMF) and post polycythemia vera/essential thrombocythemia …
    125. A phase I/II study of the Janus kinase (JAK) 1 and 2 inhibitor ruxolitinib in patients with relapsed or refractory acute myeloid leukemia
    126. A phase IIb dose‐ranging study of the oral JAK inhibitor tofacitinib (CP‐690,550) versus placebo in combination with background methotrexate in patients with active …
    127. A phase IIb study of ABT‐494, a selective JAK‐1 inhibitor, in patients with rheumatoid arthritis and an inadequate response to anti–tumor necrosis factor therapy
    128. A Practical and Scalable Method for Manufacturing JAK Inhibitor ASP3627
    129. A randomized phase 2b trial of baricitinib, an oral Janus kinase (JAK) 1/JAK2 inhibitor, in patients with moderate‐to‐severe psoriasis
    130. A retrospective cohort study comparing utilization and costs of biologic therapies and JAK inhibitor therapy across four common inflammatory indications in …
    131. A32 NEW ASTHMA THERAPIES: CLINICAL STUDIES: In Vitro Profile Of The New Pan-JAK Inhibitor Compound A
    132. AB0066 THE JAK INHIBITOR (BARICITINIB) INHIBITS IFNΓ-INDUCED GLIOSTATIN EXPRESSION IN HUMAN FIBROBLAST-LIKE SYNOVIOCYTES
    133. AB0076 JAK inhibitor baricitinib modulates human innate and adaptive immune system
    134. AB0434 EARLY EXPERIENCE WITH JAK INHIBITOR PRESCRIBING IN THE UK: RESULTS FROM THE BRITISH SOCIETY FOR RHEUMATOLOGY BIOLOGICS …
    135. Aberrant cytokine production by nonmalignant cells in the pathogenesis of myeloproliferative tumors and response to JAK inhibitor therapies
    136. Abstract CT144: preclinical and clinical studies and modeling and simulation to identify phase II dose for cerdulatinib: a dual SYK/JAK inhibitor for the treatment of B …
    137. Abstract P2-08-03: Targeting inflammatory pathways: A phase 2 trial of the JAK-inhibitor ruxolitinib in combination with exemestane for aromatase inhibitor-resistant …
    138. Accumulation of JAK activation loop phosphorylation is linked to type I JAK inhibitor withdrawal syndrome in myelofibrosis
    139. ACTIVITY OF THE NOVEL AND SELECTIVE PANJANUS KINASE (JAK) INHIBITOR VR588 IN A MURINE POLYINOSINIC: POLYCYTIDILIC ACID (POLY (I: C)) …
    140. Allo-SCT for myelofibrosis: reversing the chronic phase in the JAK inhibitor era?
    141. Anti-adult T‑cell leukemia/lymphoma activity of cerdulatinib, a dual SYK/JAK kinase inhibitor
    142. Antiangiogenic and antimetastatic activity of JAK inhibitor AZD1480
    143. Anti-inflammatory effects of the JAK inhibitor tofacitinib in two murine house dust mite-driven models of asthma.
    144. AS2553627, a novel JAK inhibitor, prevents chronic rejection in rat cardiac allografts
    145. ASN002: A novel dual SYK/JAK inhibitor with strong antitumor activity
    146. ASN002: A novel dual SYK/JAK inhibitor with strong antitumor activity in both hematological and solid tumor xenograft models
    147. Atypical chronic myeloid leukemia with concomitant CSF3R T618I and SETBP1 mutations unresponsive to the JAK inhibitor ruxolitinib
    148. AZD1480, a JAK inhibitor, inhibits cell growth and survival of colorectal cancer via modulating the JAK2/STAT3 signaling pathway
    149. Baricitinib: The Second FDA-Approved JAK Inhibitor for the Treatment of Rheumatoid Arthritis
    150. Beyond JAK inhibitor therapy in myelofibrosis
    151. Biology and clinical management of myeloproliferative neoplasms and development of the JAK inhibitor ruxolitinib
    152. C32 ASTHMA: PRE-CLINICAL STUDIES: New Inhaled Pan-JAK Inhibitor A Is Efficacious At Reducing Allergen-Induced Airway Inflammation In Rat
    153. C34 NEW BASIC SCIENCE IN ASTHMA: ALLERGIC INFLAMMATION I: The Selective Pan-Janus Kinase (jak) Inhibitor Vr588 Demonstrates Potent Anti-Inflammatory …
    154. Calcineurin‐Inhibitor‐Free Immunosuppression Based on the JAK Inhibitor CP‐690,550: A Pilot Study in De Novo Kidney Allograft Recipients
    155. Calreticulin mutant mice develop essential thrombocythemia that is ameliorated by the JAK inhibitor ruxolitinib
    156. Case report: successful treatment of refractory SAPHO syndrome with the JAK inhibitor tofacitinib
    157. CD45 antigen negativity in T-lineage ALL correlates with PTPRC mutation and sensitivity to a selective JAK inhibitor.
    158. Cerdulatinib (PRT062070): A dual SYK/JAK inhibitor in patients with relapsed/refractory b-cell malignancies—Pharmacokinetic and pharmacodynamic outcomes with …
    159. Challenges facing JAK inhibitor therapy for myeloproliferative neoplasms
    160. CHZ868, a type II JAK2 inhibitor, reverses type I JAK inhibitor persistence and demonstrates efficacy in myeloproliferative neoplasms
    161. Clinical activity, safety and tolerability of ASN002, a dual SYK/JAK inhibitor, in patients non-Hodgkin lymphoma (NHL) and solid tumors.
    162. Clinical utility of the oral JAK inhibitor tofacitinib in the treatment of rheumatoid arthritis
    163. Co‐administration of the JAK inhibitor CP‐690,550 and methotrexate is well tolerated in patients with rheumatoid arthritis without need for dose adjustment
    164. Combination synergy of JAK inhibitor, BVB808, and FGFR inhibitor, BGJ398, in an FGFR3-driven multiple myeloma model
    165. Combination Therapy of Selective MMP9 Inhibitor and JAK Inhibitor Is Effective to Induce Disease Control in Mouse DSS Model of Colitis: 593
    166. Combined Therapy With BRD4 Antagonist and JAK Inhibitor Is Synergistically Lethal Against Human Myeloproliferative Neoplasm (MPN) Cells
    167. Combined use of tofacitinib (pan-JAK inhibitor) and ruxolitinib (a JAK1/2 inhibitor) for refractory T-cell prolymphocytic leukemia (T-PLL) with a JAK3 mutation
    168. Cytokine-mediated signals as targets for treatment of rheumatoid arthritis: a JAK inhibitor in vitro and in vivo
    169. Development of a Scalable Synthesis for an Inhaled pan-JAK Inhibitor
    170. Discovery and structural characterization of peficitinib (ASP015K) as a novel and potent JAK inhibitor
    171. Discovery of CP-690,550: a potent and selective Janus kinase (JAK) inhibitor for the treatment of autoimmune diseases and organ transplant rejection
    172. Disease course and treatment effects of a JAK inhibitor in a patient with CANDLE syndrome
    173. Distinct acute lymphoblastic leukemia (ALL)-associated Janus kinase 3 (JAK3) mutants exhibit different cytokine-receptor requirements and JAK inhibitor specificities
    174. DOP076 A phase 2B, multicenter, randomized, placebo-controlled dose-ranging trial of peficitinab, an oral JAK inhibitor, in patients with moderately to severely active …
    175. DOP53 Clinical, endoscopic, histological and biomarker activity following treatment with the gut-selective, pan-JAK inhibitor TD-1473 in moderately to severely active …
    176. DRESS syndrome and reversible liver function abnormalities in patients with systemic lupus erythematosus treated with the highly selective JAK-1 inhibitor …
    177. Effect of filgotinib, a selective JAK 1 inhibitor, with and without methotrexate in patients with rheumatoid arthritis: patient-reported outcomes
    178. Effective JAK inhibitor therapy in rheumatoid arthritis: can methotrexate be discontinued?
    179. Effective prevention and treatment of CD8 T cell-mediated graft-versus-host-like disease (GvHD) using a JAK inhibitor.(51.3)
    180. Effects of a JAK inhibitor, AG490, on proliferation and apoptosis of human nasopharyngeal carcinoma cell line CNE-2Z
    181. Effects of a JAK inhibitor, AG490, on proliferation and survivin expression of breast cancer cell line MDA-MB-231
    182. Effects Of PF-956980, A Pan JAK Inhibitor, On Glucocorticosteroid Resistant Release Of CXCR3 Chemokines From Human bronchial Epithelial Cells
    183. Effects of the novel aurora kinase/JAK inhibitor, AT9283 and imatinib on Philadelphia positive cells in vitro
    184. Efficacy and safety of ABT‐494, a selective JAK‐1 inhibitor, in a phase IIb study in patients with rheumatoid arthritis and an inadequate response to …
    185. Efficacy and safety of JAK inhibitor INC424 in patients with primary and post-polycythemia vera or post-essential thrombocythemia myelofibrosis in the Chinese …
    186. Efficacy and safety of JAK inhibitor ruxolitinib in Chinese patients with myelofibrosis: results of a 1-year follow-up of A2202
    187. Efficacy and safety of the dual SYK/JAK inhibitor cerdulatinib in patients with relapsed or refractory B-cell malignancies: Results of a phase I study.
    188. Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Filgotinib, a Selective JAK‐1 Inhibitor, After Short‐Term Treatment of Rheumatoid Arthritis: Results of …
    189. Elevation of the hepatitis B virus DNA during the treatment of polycythemia vera with the JAK kinase inhibitor ruxolitinib
    190. Enhanced antitumor activity of cetuximab in combination with the JAK inhibitor cyt387 against non-small-cell lung cancer with various genotypes
    191. Evaluation of the in vitro and in vivo efficacy of the JAK inhibitor AZD1480 against JAK-mutated acute lymphoblastic leukemia
    192. Flavopiridol disrupts STAT3/DNA interactions, attenuates STAT3-directed transcription, and combines with the JAK kinase inhibitor AG490 to achieve cytotoxic synergy
    193. FLLL12 is a small molecule JAK2 inhibitor that inhibits JAK-STAT3 pathway in head and neck cancer
    194. FRI0041 The JAK Inhibitor (Tofacitinib) Inhibits TNF-Induced Gliostatin/thymidine Phosphorylase Expression in Human Fibroblast-like Synoviocytes
    195. Gö6976 is a potent inhibitor of the JAK 2 and FLT3 tyrosine kinases with significant activity in primary acute myeloid leukaemia cells
    196. Heterodimeric JAK–STAT activation as a mechanism of persistence to JAK2 inhibitor therapy
    197. Immunotherapy: JAK inhibitor effective in rheumatoid arthritis
    198. Impact of treatment of a JAK inhibitor on experimental Candida sepsis: Keeping the balance of inflammation prolongs survival
    199. In vitro and in vivo analysis of a JAK inhibitor in rheumatoid arthritis
    200. In vitro pharmacological characterization of the potent, lung selective pan-JAK inhibitor TD-8236
    201. In vitro profile of the new inhaled pan-JAK inhibitor LAS194046
    202. In vitro/in vivo investigations to examine the gender differences in the pharmacokinetics of novel oral Janus kinase (JAK) inhibitor ASP015K and sulfate metabolite M2 …
    203. Increasing Antitumor Activity of JAK Inhibitor by Simultaneous Blocking Multiple Survival Signaling Pathways in Human Ovarian Cancer
    204. Incyte comes of age with JAK inhibitor approval
    205. Influence of JAK kinase inhibitor AG490 on Lewis lung cancer cell proliferation and JAK-Stat signaling pathways
    206. Inhibition of cytokine‐induced JAK‐STAT signalling pathways by an endonuclease inhibitor aurintricarboxylic acid
    207. Inhibition of STAT3 with orally active JAK inhibitor, AZD1480, decreases tumor growth in Neuroblastoma and Pediatric Sarcomas In vitro and In vivo
    208. Inhibitory effect of JAK inhibitor on mechanical stress-induced protease expression by human articular chondrocytes
    209. Inhibitory effect of the JAK inhibitor AG490 on the STAT3 signaling pathway in laryngeal carcinoma
    210. Inhibitory effects of JAK inhibitor AG490 on invasion and migration in MCF-7 cells [J]
    211. Inhibitory effects of the JAK inhibitor CP690, 550 on human CD4+ T lymphocyte cytokine production
    212. In-vitro evaluation of a new potent, selective pan-Janus kinase (JAK) inhibitor VR588
    213. JAK inhibitor
    214. JAK inhibitor has the amelioration effect in lupus-prone mice: the involvement of IFN signature gene downregulation
    215. JAK inhibitor improves type I interferon induced damage: proof of concept in dermatomyositis
    216. JAK inhibitor in CALR-mutant myelofibrosis.
    217. JAK inhibitor induces S phase cell-cycle arrest and augments TRAIL-induced apoptosis in human hepatocellular carcinoma cells
    218. JAK inhibitor JTE-052 regulates contact hypersensitivity by downmodulating T cell activation and differentiation
    219. JAK inhibitor ruxolitinib inhibits the expression of cytokines characteristic of cutaneous lupus erythematosus
    220. JAK inhibitor shows potential for CNI-free immunosuppression, but regimen needs refining
    221. JAK inhibitor therapy for myelofibrosis: critical assessment of value and limitations
    222. JAK Inhibitor Therapy: Safer Than You Might Think
    223. JAK inhibitor tofacitinib for treating rheumatoid arthritis: from basic to clinical
    224. JAK inhibitor: tofacitinib, a new disease modifying anti-rheumatic drug
    225. JAK inhibitor; possibility and mechanism as a new disease modifying anti-rheumatic drug.
    226. JAK1-STAT3 blockade by JAK inhibitor SHR0302 attenuates inflammatory responses of adjuvant-induced arthritis rats and decreases Th17 and total B cells
    227. JAK-inhibitor tofacitinib suppresses interferon alfa production by plasmacytoid dendritic cells and inhibits arthrogenic and antiviral effects of interferon alfa
    228. Leptin stimulates tissue inhibitor of metalloproteinase-1 in human hepatic stellate cells respective roles of the Jak/Stat and JAK-Mediated H2O2-Dependent MAPK …
    229. LONG-TERM FOLLOW UP OF JAK INHIBITOR (JAKI) TREATED PATIENTS WITH MYELOFIBROSIS: IMPACT OF MOLECULAR ENHANCED INTEGRATED …
    230. Low dose CP-690,550 (tofacitinib), a pan-JAK inhibitor, accelerates the onset of experimental autoimmune encephalomyelitis by potentiating Th17 differentiation
    231. Mathematical modeling reveals alternative JAK inhibitor treatment in myeloproliferative neoplasms
    232. Methotrexate is a Jak/Stat pathway inhibitor
    233. Model based targeting of IL-6-induced inflammatory responses in cultured primary hepatocytes to improve application of the JAK inhibitor Ruxolitinib
    234. Models to Predict Response to JAK-inhibitor Therapy in Patients with Myelofibrosis
    235. Molecular and cellular mechanisms underlying the therapeutic efficacy of the combination of JAK inhibitor, ruxolitinib, PIM inhibitor, LGH447, and CDK4/6 inhibitor …
    236. Multifaceted intervention by the Hsp90 inhibitor ganetespib (STA-9090) in cancer cells with activated Jak/Stat signaling
    237. Myeloproliferative neoplasm in a thalassaemic patient: response to treatment with a JAK inhibitor
    238. Nephrotic syndrome in primary myelofibrosis with renal extramedullary hematopoiesis and glomerulopathy in the JAK inhibitor era
    239. New inhaled JAK inhibitor LAS194046 inhibits allergen-induced airway inflammation in Brown Norway rats
    240. Novartis JAK inhibitor provides marked and durable clinical benefits in patients with myelofibrosis, a rare, life-threatening blood cancer
    241. Novel inhaled pan-JAK inhibitor, LAS194046, reduces allergen-induced airway inflammation, late asthmatic response, and pSTAT activation in brown Norway rats
    242. Novel translational pharmacology approaches on dose reduction and alternative scheduling for the combination of JAK inhibitor, ruxolitinib, PIM inhibitor, LGH447 …
    243. OP0149 A phase 2B study of an oral JAK inhibitor ASP015K monotherapy in Japanese patients with moderate to severe rheumatoid arthritis
    244. OP0253 The JAK Inhibitor Tofacitinib Suppresses Synovial JAK1-STAT1 Signalling in Rheumatoid Arthritis
    245. P041 THE GUT-SELECTIVE, ORALLY ADMINISTERED, PAN-JAK INHIBITOR TD-1473 DEMONSTRATES FAVORABLE SAFETY, TOLERABILITY …
    246. P-177 Safety, Tolerability, and Pharmacokinetics of the Intestine-Restricted Oral Pan-JAK Inhibitor TD-1473 After Single and Multiple Oral Doses in Healthy Subjects
    247. P-269 A Combination Therapy of Selective MMP9 Inhibitor and JAK Inhibitors Is Efficacious in Mouse DSS Model of Colitis
    248. PD-009 A Phase 2B, multicenter, randomized, placebo-controlled dose-ranging trial of peficitinib, an oral JAK inhibitor, in patients with moderately-severely active UC
    249. Peficitinib, a JAK Inhibitor, in Combination With Limited Conventional Synthetic Disease‐Modifying Antirheumatic Drugs in the Treatment of Moderate‐to‐Severe …
    250. Peficitinib, a JAK Inhibitor, in the Treatment of Moderate‐to‐Severe Rheumatoid Arthritis in Patients With an Inadequate Response to Methotrexate
    251. Perspectives on the impact of JAK-inhibitor therapy upon inflammation-mediated comorbidities in myelofibrosis and related neoplasms
    252. Pfizer’s first-in-class JAK inhibitor pricey for rheumatoid arthritis market
    253. Pfizer’s JAK inhibitor hits goals in ulcerative colitis trial
    254. Pfizer’s JAK inhibitor sails through phase 3 in rheumatoid arthritis
    255. P-glycoprotein (ABCB1) and Breast Cancer Resistance Protein (ABCG2) restrict the brain penetration of the Janus family of tyrosine kinase (JAK) inhibitor CYT387
    256. Pharmacokinetics and pharmacodynamics of the dual syk/JAK inhibitor PRT062070 (cerdulatinib) in patients with advanced B-cell malignancies.
    257. Pharmacokinetics, safety and tolerability of ABT-494, a novel selective JAK 1 inhibitor, in healthy volunteers and subjects with rheumatoid arthritis
    258. Pharmacological properties of JTE-052: a novel potent JAK inhibitor that suppresses various inflammatory responses in vitro and in vivo
    259. Phase 1 open-label dose escalation study of the dual SYK/JAK inhibitor cerdulatinib (PRT062070) in patients with relapsed/refractory B-cell malignancies: Safety …
    260. Phase 3 trial of momelotinib (MMB) vs ruxolitinib (RUX) in JAK inhibitor (JAKi) naive patients with myelofibrosis (MF).
    261. Phase I/II Data Published in New England Journal of Medicine Demonstrate that Incyte JAK Inhibitor, INCB18424, Provides Marked and Durable Clinical …
    262. Phase II study of the JAK kinase inhibitor ruxolitinib in patients with refractory leukemias, including post myeloproliferative neoplasms (MPN) acute myeloid …
    263. Phase IIb dose‐ranging study of the oral JAK inhibitor tofacitinib (CP‐690,550) or adalimumab monotherapy versus placebo in patients with active rheumatoid arthritis …
    264. PHOSPHOSPECIFIC FLOW CYTOMETRY: PHARMACODYNAMIC MONITORING OF THE NOVEL JAK-INHIBITOR CP-690,550 IN KIDNEY TRANSPLANT PATIENTS …
    265. Potentiation of Nilotinib-mediated cell death in the context of the bone marrow microenvironment requires a promiscuous JAK inhibitor in CML
    266. Preclinical characterization of the Jak/Stat inhibitor SGI-1252 on skeletal muscle function, morphology, and satellite cell content
    267. Pre-Clinical Evaluation Of A Potent Janus Kinase (JAK) Inhibitor Designed For Topical Delivery In Severe Asthma
    268. Preclinical evaluation of HM-018, a potent and selective JAK inhibitor in the treatment of myloproliferative disorders
    269. Pre-Clinical Results of Islet Allo-Transplantation Using JAK Inhibitor as Replacement for Tacrolimus Widely Used Immunosuppressive Drug in Islet Transplantation in …
    270. Predictive models for splenic response to JAK-inhibitor therapy in patients with myelofibrosis
    271. Prevention of chronic renal allograft rejection by AS2553627, a novel JAK inhibitor, in a rat transplantation model
    272. Prevention of Lens Eithelial Cell Death After H2O2 Exposure Using JAK Inhibitor AG490 in Human Cataract
    273. PTU-001 Tofacitinib, an oral JAK inhibitor, in the treatment of ulcerative colitis: open-label, long-term extension study
    274. Pyridone 6, a pan-JAK inhibitor, ameliorates allergic skin inflammation of NC/Nga mice via suppression of Th2 and enhancement of Th17
    275. Rapid and Durable Responses with the SYK/JAK Inhibitor Cerdulatinib in a Phase 2 Study in Relapsed/Refractory Follicular Lymphoma-Alone or in Combination with …
    276. Replacement of mycophenolate mofetil with a JAK inhibitor, AS2553627, in combination with low-dose tacrolimus, for renal allograft rejection in non-human primates
    277. Results of a randomized study of the JAK inhibitor INC424 compared with best available therapy (BAT) in primary myelofibrosis (PMF), post-polycythemia vera …
    278. Results of a randomized study of the JAK inhibitor ruxolitinib (INC424) versus best available therapy (BAT) in primary myelofibrosis (PMF), post-polycythemia vera …
    279. Reversal of CD8 T-cell–mediated mucocutaneous graft-versus-host-like disease by the JAK inhibitor tofacitinib
    280. Role of Jak3-Stat6 and effect of JAK inhibitor on dendritic cells and its involvement in rheumatoid arthritis
    281. Safety and efficacy of the JAK inhibitor tofacitinib citrate in patients with alopecia areata
    282. Selective downregulation of JAK2 and JAK3 by an ATP-competitive pan-JAK inhibitor
    283. Selective Immunomodulation of Inflammatory Pathways in Keratinocytes by the Janus Kinase (JAK) Inhibitor Tofacitinib: Implications for the Employment of JAK …
    284. Serum human beta-defensin-2 is a possible biomarker for monitoring response to JAK inhibitor in psoriasis patients
    285. Simultaneous improvement of alopecia universalis and atopic dermatitis in a patient treated with a JAK inhibitor
    286. Successful treatment of palmoplantar pustulosis with rheumatoid arthritis, with tofacitinib: Impact of this JAK inhibitor on T-cell differentiation.
    287. Superior lethal activity of single agent BET protein PROTAC compared to bromodomain inhibitor or in combination with JAK inhibitor against post-myelofibrosis …
    288. Suppress for Success: A JAK Inhibitor for Adjunct Therapy of Tuberculosis
    289. Symptom assessment in patients with JAK inhibitor naive and JAK inhibitor failed myelofibrosis.
    290. Synthesis of pan-JAK Inhibitor PF-06263276
    291. Targeting compensatory MEK/ERK activation increases JAK inhibitor efficacy in myeloproliferative neoplasms
    292. The combination of JAK inhibitor, ruxolitinib, and PIM inhibitor, LGH447, in preclinical models of myeloproliferative neoplasia
    293. The combination of JAK inhibitor, ruxolitinib, pan-PIM inhibitor, LGH447, and CDK4/6 inhibitor, LEE011, in a preclinical mouse model of myeloproliferative neoplasia
    294. The dual Syk/JAK inhibitor cerdulatinib antagonizes B-cell receptor and microenvironmental signaling in chronic lymphocytic leukemia
    295. THE DUAL SYK/JAK INHIBITOR CERDULATINIB DEMONSTRATES RAPID AND DURABLE TUMOR RESPONSES IN A PHASE 2 STUDY IN RELAPSED …
    296. The dual SYK/JAK inhibitor cerdulatinib demonstrates rapid tumor responses in a phase 2 study in patients with relapsed/refractory B-and T-cell non-Hodgkin …
    297. The Effect of JAK-Inhibitor Tofacitinib on Intestinal Epithelial Barrier Function
    298. The effect of the JAK inhibitor CP-690,550 on peripheral immune parameters in stable kidney allograft patients
    299. The effect of the JAK2 inhibitor TG101209 against T cell acute lymphoblastic leukemia (T-ALL) is mediated by inhibition of JAK-STAT signaling and activation …
    300. The Effect of Verapamil, a P‐Glycoprotein Inhibitor, on the Pharmacokinetics of Peficitinib, an Orally Administered, Once‐Daily JAK Inhibitor
    301. The effects of a JAK inhibitor AG490 combined DDP on the cervical cancer model in nude mice
    302. The effects of JAK inhibitor therapy upon novel markers of thrombosis in myeloproliferative neoplasms
    303. The JAK inhibitor antcin H exhibits direct anticancer activity while enhancing chemotherapy against LMP1-expressed lymphoma
    304. The JAK inhibitor AZD1480 regulates proliferation and immunity in Hodgkin lymphoma
    305. The JAK inhibitor CP-690,550 (tofacitinib) inhibits TNF-induced chemokine expression in fibroblast-like synoviocytes: autocrine role of type I interferon
    306. The JAK Inhibitor CP‐690,550 Preserves the Function of CD4+CD25brightFoxP3+ Regulatory T Cells and Inhibits Effector T Cells
    307. The JAK inhibitor ruxolitinib reduces inflammation in an ILC3-independent model of innate immune colitis
    308. The JAK inhibitor tofacitinib ameliorates immune‑mediated liver injury in mice
    309. The JAK inhibitor tofacitinib for active rheumatoid arthritis: results from phase III trials
    310. The JAK inhibitor tofacitinib suppresses synovial JAK1-STAT signalling in rheumatoid arthritis
    311. The JAK inhibitor, tofacitinib, reduces the T cell stimulatory capacity of human monocyte-derived dendritic cells
    312. The JAK inhibitor, tofacitinib, rescues IFN-γ-induced barrier permeability in human colonoids and acts independent of tight junction protein expression changes in T84 …
    313. The JAK kinase inhibitor CP‐690,550 supresses the growth of human polycythemia vera cells carrying the JAK2V617F mutation
    314. The JAK-3 inhibitor CP-690550 is a potent anti-inflammatory agent in a murine model of pulmonary eosinophilia
    315. The JAK-Inhibitor Tofacitinib Rescues Human Intestinal Epithelial Cells and Colonoids from Cytokine-Induced Barrier Dysfunction
    316. The JAK-inhibitor, JAB/SOCS-1 selectively inhibits cytokine-induced, but not v-Src induced JAK–STAT activation
    317. The novel JAK inhibitor AZD1480 blocks STAT3 and FGFR3 signaling, resulting in suppression of human myeloma cell growth and survival
    318. The novel JAK inhibitor CYT387 suppresses multiple signalling pathways, prevents proliferation and induces apoptosis in phenotypically diverse myeloma …
    319. The novel JAK‐3 inhibitor CP‐690550 is a potent immunosuppressive agent in various murine models
    320. The pharmacokinetics, pharmacodynamics, and safety of baricitinib, an oral JAK 1/2 inhibitor, in healthy volunteers
    321. The possible mode of action of Tofacitinib, a JAK inhibitor
    322. The potent and lung-selective inhaled pan JAK inhibitor TD-8236 limits airway inflammation without affecting systemic immunity in mice
    323. The putative JAK-STAT inhibitor AG490 exacerbates LPS-fever, reduces sickness behavior, and alters the expression of pro-and anti-inflammatory genes in the rat …
    324. The safety and efficacy of a JAK inhibitor in patients with active rheumatoid arthritis: results of a double‐blind, placebo‐controlled phase IIa trial of three dosage levels …
    325. The selective Pan-Janus kinase (JAK) inhibitor VR588 demonstrates potent anti-inflammatory activity in a murine chronic house dust mite (HDM) model of …
    326. The SYK\JAK inhibitor cerdulatinib (PRT062070) shows promising preclinical activity in chronic lymphocytic leukemia by antagonising B-cell receptor and …
    327. The telomerase inhibitor imetelstat in patients (pts) with intermediate-2 or high-risk myelofibrosis (MF) previously treated with Janus kinase (JAK) inhibitor: A phase 2 …
    328. Therapeutic potential of Jak/Stat signal inhibition in prostate cancer by the JAK inhibitor AZD1480.
    329. THU0101 ASP015K: A Novel JAK Inhibitor Demonstrated Potent Efficacy in Adjuvant-Induced Arthritis Model in Rats
    330. THU0136 Cardiovascular safety findings in rheumatoid arthritis patients treated with tofacitinib (CP-690,550), a novel, oral JAK inhibitor
    331. THU0145 A multi-biomarker disease activity (MBDA) score measures rheumatoid arthritis disease activity in patients treated with the JAK inhibitor tofacitinib
    332. THU0185 Tofacitinib, An Oral JAK Inhibitor, in The Treatment of Rheumatoid Arthritis: Safety and Clinical and Radiographic Efficacy in Open-Label, Long-Term …
    333. THU0227 Pooled Analysis of Clinical Safety Data for ASP015K, a Novel JAK Inhibitor in Development for Treatment of Autoimmune Diseases
    334. THU0258 oral start: effects of the oral JAK inhibitor tofacitinib monotherapy versus methotrexate on patient-reported outcomes in the phase 3 oral start trial of active …
    335. Tofacitinib (Xeljanz): The First‐in‐Class JAK Inhibitor for the Treatment of Rheumatoid Arthritis
    336. Tofacitinib, a JAK inhibitor, inhibits human B cell activation in vitro
    337. Tofacitinib: Novel JAK inhibitor for RA
    338. Tofacitinib: The First Janus Kinase (JAK) inhibitor for the treatment of rheumatoid arthritis
    339. Tolerability and response of the novel SYK/JAK inhibitor cerdulatinib in a phase 2a study in relapsed/refractory peripheral t cell lymphoma (PTCL).
    340. Tumoricidal effects of the JAK inhibitor Ruxolitinib (INC424) on hepatocellular carcinoma in vitro
    341. VX‐509 (Decernotinib), an oral selective JAK‐3 inhibitor, in combination with methotrexate in patients with rheumatoid arthritis
    342. WITHDRAWN: Nephrotic syndrome in primary myelofibrosis with renal extramedullary hematopoiesis and glomerulopathy in the JAK inhibitor era.
    343. JAK-inhibitor-approved-for-ulcerative-colitis”>Xeljanz (Tofacitinib) Receives Expanded Indication, Becoming the First Oral JAK Inhibitor Approved for Ulcerative Colitis
    344. JAK-inhibitor-approved-for-patients-with-rheumatoid-arthritis”>Xeljanz XR (Tofacitinib) First Once-Daily Oral JAK Inhibitor Approved for Patients with Rheumatoid Arthritis
    345. JAK-inhibitor-now-approved-for-adults-with-active-psoriatic-arthritis”>Xeljanz/Xeljanz XR (Tofacitinib/Tofacitinib XR), an Oral JAK Inhibitor, Now Approved for Adults with Active Psoriatic Arthritis
    346. Blueberry and malvidin inhibit cell cycle progression and induce mitochondrial-mediated apoptosis by abrogating the Jak/Stat-3 signalling pathway
    347. Dysregulation of Jak/Stat genes by vasoactive intestinal peptide (VIP) in Salmonella-infected monocytes may inhibit its therapeutic potential in human sepsis
    348. Environmental toxicants inhibit neuronal JAK tyrosine kinase by mitochondrial disruption
    349. Gamma-Aminobutyric Acid Binds to GABAB Receptor to Inhibit Cholangiocarcinoma Cells Growth via the Jak/Stat3 Pathway
    350. gold nanoparticles using Euphrasia officinalisleaf extract to inhibit lipopolysaccharide-induced inflammation through NF-κB and Jak/Stat pathways in …
    351. gp130 associated molecule inhibit the association of JAK kinase with gp130
    352. Human immunodeficiency virus‐1 envelope glycoproteins and anti‐CD4 antibodies inhibit interleukin‐2‐induced Jak/Stat signalling in human CD4 T lymphocytes
    353. IFN-λs inhibit Hantaan virus infection through the JAK-STAT pathway and expression of Mx2 protein
    354. Indomethacin leads to poor prognoses through promoting the expression of PD-1 and PD-L2 via TRIF/NF-κB pathway and Jak/Stat3 pathway to inhibit TNF-α and …
    355. Inducing apoptosis to inhibit inflammatory proliferation of IL-6-induced fibroblast-like synoviocytes through modulating the activation of Jak/Stat and NF …
    356. Insulin potentiates Jak/Stat signaling to broadly inhibit flavivirus replication in insect vectors
    357. Iron Chelators and Hypoxia Mimetics Inhibit IFNγ-Mediated JAK-STAT Signaling
    358. JAK 2‐V 617 F‐mediated signalling is dependent on lipid rafts and statins inhibit JAK 2‐V 617 F‐dependent cell growth
    359. Jak/Stat Inhibitor Has Potential To Inhibit Intervertebral Disc Degeneration: o171
    360. Lambda-Interferons inhibit Herpes Simplex Virus Type 2 Replication in Human Cervical Epithelial Cells through Activation of Jak/Stat Pathway
    361. luteolin synergistically inhibit the proliferation of interleukin-1 β-induced fibroblast-like synoviocytes through regulating the activation of NF-κ B and JAK …
    362. Metformin and aspirin synergistically inhibit mTOR and Jak/Stat3 signaling pathway and induce cell death in pancreatic cancer cells
    363. miR-409 down-regulates JAK-Stat pathway to inhibit progression of liver cancer
    364. Myricitrin modulates NADPH oxidase-dependent ROS production to inhibit endotoxin-mediated inflammation by blocking the Jak/Stat1 and NOX2/p47phox …
    365. Nonstructural protein of severe fever with thrombocytopenia syndrome phlebovirus targets STAT2 and not STAT1 to inhibit type I interferon-stimulated JAK-STAT …
    366. Novel mechanisms to inhibit HIV reservoir seeding using JAK inhibitors
    367. Ovarian carcinoma cells inhibit T cell proliferation: suppression of IL-2 receptor β and γ expression and their JAK-STAT signaling pathway
    368. Pacritinib to inhibit Jak/Stat signaling in refractory metastatic colon and rectal cancer
    369. The Nucleoprotein and Phosphoprotein of Peste des Petits Ruminants Virus Inhibit Interferons Signaling by Blocking the JAK-STAT Pathway
    370. Varicella viruses inhibit interferon-stimulated JAK-STAT signaling through multiple mechanisms
    371. 1, 25 (OH) 2D3 suppresses proinflammatory responses by inhibiting Th1 cell differentiation and cytokine production through the Jak/Stat pathway
    372. Abstract# 2971: Benzyl isothiocyanate induces apoptosis in human pancreatic cancer cells by inhibiting Jak/Stat pathway
    373. ALA‐PDT alleviates the psoriasis by inhibiting JAK signaling pathway
    374. Angelica sinensis polysaccharide promotes apoptosis by inhibiting Jak/Stat pathway in breast cancer cells
    375. Aspirin increases ferroportin 1 expression by inhibiting hepcidin via the Jak/Stat3 pathway in interleukin 6-treated PC-12 cells
    376. Cadmium and mercury suppress cytokine receptor-mediated Jak/Stat activation by inhibiting mitochondrial function and increasing intracellular oxidative …
    377. Crocin promotes apoptosis of human skin cancer cells by inhibiting the Jak/Stat pathway
    378. Cryptotanshinone sensitizes antitumor effect of paclitaxel on tongue squamous cell carcinoma growth by inhibiting the Jak/Stat3 signaling pathway
    379. Curcumin improves the recovery of motor function and reduces spinal cord edema in a rat acute spinal cord injury model by inhibiting the Jak/Stat signaling pathway
    380. Dexmedetomidine protects against renal ischemia and reperfusion injury by inhibiting the Jak/Stat signaling activation
    381. Effect of Dishevelled 2 on apoptosis in rheumatoid arthritis fibroblast-like synoviocytes through inhibiting JAK-STAT pathway
    382. Effects of inhibiting JAK on invasion and metastasis of the human breast cancer cells through ERK signaling transduction pathway
    383. Effects of propofol on myocardial ischemia reperfusion injury through inhibiting the Jak/Stat pathway.
    384. Epigallocatechin-3-gallate ameliorates seawater aspiration-induced acute lung injury via regulating inflammatory cytokines and inhibiting Jak/Stat1 pathway in rats
    385. Esculetin Inhibits Proliferation, Invasion, and Migration of Laryngeal Cancer In Vitro and In Vivo by Inhibiting Janus Kinas (JAK)-Signal Transducer and …
    386. Essential oil of Artemisia argyi suppresses inflammatory responses by inhibiting Jak/Stats activation
    387. Feifukang ameliorates pulmonary fibrosis by inhibiting JAK-STAT signaling pathway
    388. Formononetin ameliorates high glucose‑induced endothelial dysfunction by inhibiting the Jak/Stat signaling pathway
    389. Genkwanin ameliorates adjuvant-induced arthritis in rats through inhibiting Jak/Stat and NF-κB signaling pathways
    390. Ginkgo biloba extract EGb761 attenuates brain death-induced renal injury by inhibiting pro-inflammatory cytokines and the SAPK and JAK-STAT signalings
    391. HEV ORF3 downregulatesCD14 and CD64 to impair macrophages phagocytosis through inhibiting Jak/Stat pathway
    392. IFN-CSP inhibiting hepatitis B virus in HepG2. 2.15 cells involves JAK-STAT signal pathway
    393. IFN-γ down-regulates ABCA1 expression by inhibiting LXRα in a Jak/Stat signaling pathway-dependent manner
    394. Interferon-gamma inhibits the neuronal differentiation of neural progenitor cells by inhibiting the expression of Neurogenin2 via the Jak/Stat1 pathway
    395. Ischemic postconditioning during reperfusion attenuates intestinal injury and mucosal cell apoptosis by inhibiting Jak/Stat signaling activation
    396. Knockdown of HE4 suppresses aggressive cell growth and malignant progression of ovarian cancer by inhibiting the Jak/Stat3 pathway
    397. Liraglutide Exerts Potential Anti-inflammatory Effect in Type 1 Diabetes by Inhibiting IFN-γ Production via Suppressing JAK-STAT Pathway.
    398. Losartan reduces myocardial interstitial fibrosis in diabetic cardiomyopathy rats by inhibiting Jak/Stat signaling pathway
    399. Lowly expressed EGFR-AS1 promotes the progression of preeclampsia by inhibiting the EGFR-Jak/Stat signaling pathway
    400. Matrine increases NKG2D ligand ULBP2 in K562 cells via inhibiting Jak/Stat3 pathway: A potential mechanism underlying the immunotherapy of matrine in …
    401. MicroRNA-210 promotes spinal cord injury recovery by inhibiting inflammation via the JAK-STAT pathway
    402. MiR-17 Regulates Prostate Cancer Cell Proliferation and Apoptosis Through Inhibiting JAK-STAT3 Signaling Pathway
    403. MiR-21 inhibitor improves locomotor function recovery by inhibiting IL-6R/JAK-STAT pathway-mediated inflammation after spinal cord injury in model of rat
    404. Oleanolic acid inhibiting the differentiation of neural stem cells into astrocyte by down-regulating Jak/Stat signaling pathway
    405. Phytosphingosine Derivatives Ameliorate Skin Inflammation by Inhibiting NF-κB and Jak/Stat Signaling in Keratincoytes and Mice
    406. Protein inhibitor of activated STAT (PIAS) negatively regulates the Jak/Stat pathway by inhibiting STAT phosphorylation and translocation
    407. Pyruvate Protects Against Intestinal Injury by Inhibiting the Jak/Stat Signaling Pathway in Rats With Hemorrhagic Shock
    408. Recombinant human brain natriuretic peptide ameliorates trauma-induced acute lung injury via inhibiting Jak/Stat signaling pathway in rats
    409. Simvastatin attenuated cardiac hypertrophy via inhibiting JAK-STAT pathways
    410. SOCS2 exacerbates myocardial injury induced by ischemia/reperfusion in diabetic mice and H9c2 cells through inhibiting the JAK-STAT-IGF-1 pathway
    411. The VHL tumor suppressor protein regulates tumorigenicity of U87-derived glioma stem-like cells by inhibiting the Jak/Stat signaling pathway
    412. TM‐233, a novel analog of 1′‐acetoxychavicol acetate, induces cell death in myeloma cells by inhibiting both Jak/Stat and proteasome activities
    413. 1693-P: Rapamycin Reduces Maternal Diabetes-Induced Neural Tube Defects by Suppressing Premature Senescence
    414. 17beta-estradiol attenuates TNF-α-induced premature senescence of nucleus pulposus cells through regulating the ROS/NF-κB pathway
    415. 2, 3, 7, 8-Tetrachlorodibenzo-P-dioxin (TCDD) induces premature senescence in human and rodent neuronal cells via ROS-dependent mechanisms
    416. 2, 3, 7, 8‐Tetrachlorodibenzo‐p‐dioxin induces premature senescence of astrocytes via WNT/β‐catenin signaling and ROS production
    417. 2.1 The centrosomal protein TACC3 controls paclitaxel sensitivity by modulating a premature senescence program
    418. 5-FU-injured bone marrow stromal cells initiate stress-induced premature senescence of hematopoietic cells
    419. 5-methoxytryptophan protects MSCs from stress induced premature senescence by upregulating FoxO3a and mTOR
    420. 68: Stress-induced premature senescence in airway epithelium and accelerated lung allograft aging
    421. A bioactive polysaccharide TLH-3 isolated from Tricholoma lobayense protects against oxidative stress-induced premature senescence in cells and mice
    422. A Comparative Analysis of Stress Granule Assembly in Replicative and Stress-Induced Premature Senescence
    423. A comparison of replicative senescence and doxorubicin-induced premature senescence of vascular smooth muscle cells isolated from human aorta
    424. A Highlights from MBoC Selection: Inhibition of nuclear factor-erythroid 2–related factor (Nrf2) by caveolin-1 promotes stress-induced premature senescence
    425. A Micro-RNA Connection in-Mediated Premature Senescence of Human Melanocytes
    426. A positive feedback loop between Pim-1 kinase and HBP1 transcription factor contributes to hydrogen peroxide-induced premature senescence and apoptosis
    427. A Possible Role of Stress-Induced Premature Senescence, SIPS, as a Producer of the Stress-Resistant Microenvironment
    428. A Preliminary Study on Relationship between Leaf Premature Senescence Characteristic and Leaf N Content, Roots Activity in Hybrid Rice during Grain Filling Stage …
    429. A quantitative chemiluminescent method for studying replicative and stress-induced premature senescence in cell cultures
    430. A role for mitochondrial oxidants in stress-induced premature senescence of human vascular smooth muscle cells
    431. A single cytosine deletion in the OsPLS1 gene encoding vacuolar-type H+-ATPase subunit A1 leads to premature leaf senescence and seed dormancy in rice
    432. A steroid like phytochemical Antcin M is an anti-aging reagent that eliminates hyperglycemia-accelerated premature senescence in dermal fibroblasts by …
    433. A system biology approach to provide a mechanistic understanding of radiation induced premature senescence in endothelial cells
    434. AB0088 Deficient Autophagy Induces Premature Senescence in Aging and Osteoarthritis
    435. Abiotic Stresses Intervene with ABA Signaling to Induce Destructive Metabolic Pathways Leading to Death: Premature Leaf Senescence in Plants
    436. Ablation of galectin-3 induces p27KIP1-dependent premature senescence without oncogenic stress
    437. Abnormal mitosis in hypertetraploid cells causes aberrant nuclear morphology in association with H2O2‐induced premature senescence
    438. Absence of premature senescence in Werner’s syndrome keratinocytes
    439. Abstract A60: Role of telomere dysfunction in the premature cellular senescence of Hutchinson‐Gilford progeria syndrome
    440. Abstract B36: Premature senescence is enhanced by PKCeta and its polymorphic variant V374I
    441. Abstract# 3472: HdmX overexpression inhibits oncogenic ras induced premature senescence.
    442. Accelerated premature stress-induced senescence of young annulus fibrosus cells of rats by high glucose-induced oxidative stress
    443. Accelerated Senescence of Cord Blood Endothelial Progenitor Cells From Premature Neonates is Driven by Sirt1 Decreased Expression
    444. Accumulation of Reactive Oxygen Species and Induction of Premature Senescence: Role of DDB2
    445. Acetyl‐11‐keto‐β‐boswellic acid triggers premature senescence via induction of DNA damage accompanied by impairment of DNA repair genes in hepatocellular …
    446. Actin-binding doliculide causes premature senescence in p53 wild type cells
    447. Activation of a cAMP Pathway and Induction of Melanogenesis Correlate with Association of p16INK4 and p27KIP1 to CDKs, Loss of E2F-Binding Activity, and Premature Senescence of Human Melanocytes
    448. Activation of a PGC-1-related coactivator (PRC)-dependent inflammatory stress program linked to apoptosis and premature senescence
    449. Activation of p38 and changes in mitochondria accompany autophagy to premature senescence-like phenotype switch upon chronic exposure to selenite in colon …
    450. Activation of p53 with Nutlin-3a radiosensitizes lung cancer cells via enhancing radiation-induced premature senescence
    451. Acute activation of AMP-activated protein kinase prevents H2O2-induced premature senescence in primary human keratinocytes
    452. Additive effects of C2-ceramide on paclitaxel-induced premature senescence of human lung cancer cells
    453. Adiponectin corrects premature cellular senescence and normalizes antimicrobial peptide levels in senescent keratinocytes
    454. Adiponectin prevents diabetic premature senescence of endothelial progenitor cells and promotes endothelial repair by suppressing the p38 MAP kinase/p16INK4A …
    455. Adiponectin suppresses UVB-induced premature senescence and hBD2 overexpression in human keratinocytes
    456. Adult Sox2+ stem cell exhaustion in mice results in cellular senescence and premature aging
    457. Advances in understanding leaf premature senescence and its molecular mechanism in rice
    458. Agents that cause DNA double strand breaks lead to p16INK4a enrichment and the premature senescence of normal fibroblasts
    459. Aging with ING: a comparative study of different forms of stress induced premature senescence
    460. Akt determines replicative senescence and oxidative or oncogenic premature senescence and sensitizes cells to oxidative apoptosis
    461. ALA-PDT elicits oxidative damage and apoptosis in UVB-induced premature senescence of human skin fibroblasts
    462. Altered myogenesis and premature senescence underlie human TRIM32-related myopathy
    463. AMPK-mediated downregulation of connexin43 and premature senescence of mesangial cells under high-glucose conditions
    464. An in vitro study on biological characteristics of bone marrow mesenchymal stem cells in microenvironment of premature senescence of nucleus pulposus cells
    465. Analysing the contribution of ATM/ATR pathway activation in establishing the premature senescence of E2F1/E2F2-/-bone-marrow-derived macrophages
    466. Analysis and gene mapping of rice premature senescence mutant zs.
    467. Analysis of mineral element content in premature senescence walnut leaves under drip irrigation and fertilization condition [J]
    468. Analysis on relationship among cotton premature senescence, red leaf disease and Alternaria leaf spot disease.
    469. Androgen receptor accelerates premature senescence of human dermal papilla cells in association with DNA damage
    470. Androgenic alopecia and stress-induced premature senescence by cumulative ultraviolet light exposure
    471. Angelica sinensis polysaccharides ameliorate stress-induced premature senescence of hematopoietic cell via protecting bone marrow stromal cells from oxidative …
    472. Ankyrin-B syndrome: enhanced cardiac function balanced by risk of cardiac death and premature senescence
    473. Anti-aging activity of kimchi during fermentation period against oxidative stress-induced premature senescence in cellular model
    474. Anti-aging effect of black rice against H2O2-induced premature senescence
    475. Anti-aging effects and mechanisms of kimchi during fermentation under stress-induced premature senescence cellular system
    476. Anti-aging effects of cyanidin under a stress-induced premature senescence cellular system
    477. Antioxidant-Dependent Prevention of H2O2-Induced Premature Senescence in Human Endometrial Stem Cells
    478. Anti-photoaging potential of Botulinum Toxin Type A in UVB-induced premature senescence of human dermal fibroblasts in vitro through decreasing senescence …
    479. Apoptosis changes and SA-beta galactosidase expression in stress-induced premature senescence (SIPS) model of human skin fibroblasts.
    480. Arsenic increases Pi-mediated vascular calcification and induces premature senescence in vascular smooth muscle cells
    481. Arsenite induces premature senescence via p53/p21 pathway as a result of DNA damage in human malignant glioblastoma cells
    482. Assessing the role of stress signalling via p38 MAP kinase in the premature senescence of Ataxia Telangiectasia and Werner syndrome fibroblasts
    483. Astragaloside exerts anti-photoaging effects in UVB-induced premature senescence of rat dermal fibroblasts through enhanced autophagy
    484. Attenuation of Replication Stress–Induced Premature Cellular Senescence to Assess Anti‐Aging Modalities
    485. Attenuation of TGF-β signaling suppresses premature senescence in a p21-dependent manner and promotes oncogenic Ras-mediated metastatic transformation in …
    486. Autophagic cell death and premature senescence: New mechanism of 5-fluorouracil and sulforaphane synergistic anticancer effect in MDA-MB-231 triple negative …
    487. Autophagy impairment induces premature senescence in primary human fibroblasts
    488. Autophagy inhibition switches low-dose camptothecin-induced premature senescence to apoptosis in human colorectal cancer cells
    489. Autophagy through 4EBP1 and AMPK regulates oxidative stress-induced premature senescence in auditory cells
    490. Autophagy: The missing link between non-enzymatically glycated proteins inducing apoptosis and premature senescence of endothelial cells?
    491. B56 INFLAMMATION AND VASCULAR PERMEABILITY: Cigarette Smoke (cs) Induces Premature Senescence In Highly Proliferative Endothelial Colony Forming …
    492. Bcl-2 activates a programme of premature senescence in human carcinoma cells
    493. Bcl-2 promotes premature senescence induced by oncogenic Ras
    494. Bcl-2 protects against oxidative stress while inducing premature senescence
    495. Beryllium induces premature senescence in human fibroblasts
    496. Bisdemethoxycurcumin increases Sirt1 to antagonize t-BHP-induced premature senescence in WI38 fibroblast cells
    497. Bisphosphonates induce premature senescence and impair proliferation and migration of normal human oral keratinocytes
    498. Bmal1-deficient mouse fibroblast cells do not provide premature cellular senescence in vitro
    499. BMP4-Smad signaling pathway mediates adriamycin-induced premature senescence in lung cancer cells
    500. B-myb rescues ras-induced premature senescence, which requires its transactivation domain
    501. Bone marrow-derived mesenchymal stem cells protected rat cardiomyocytes from premature senescence
    502. Branched-chain amino acids enhance premature senescence through mammalian target of rapamycin complex I-mediated upregulation of p21 protein
    503. BRE plays an essential role in preventing replicative and DNA damage-induced premature senescence
    504. Ca2+/Redox-Sensitive Tyrosine Kinase PYK2 Promotes Atherogenesis through OxLDL/ROS/p21-Dependent Premature Senescence and Cytokine Induction in …
    505. Ca2+/Redox-Sensitive Tyrosine Kinase PYK2 Promotes Atherogenesis Through OxLDL/ROS/p21-Dependent Premature Senescence in Endothelium
    506. Cancer Biology; Inhibition of NDRG1 expression induced premature senescence
    507. Cancer cell survival following DNA damage-mediated premature senescence is regulated by mammalian target of rapamycin (mTOR)-dependent Inhibition of sirtuin 1
    508. Cancer stem cells and escape from drug-induced premature senescence in human lung tumor cells: implications for drug resistance and in vitro drug screening …
    509. Carbon filter prevents ozone fleck and premature senescence of tobacco leaves
    510. Cardiolipin activates MAP kinases during premature senescence in normal human fibroblasts
    511. Cardiolipin induces premature senescence in normal human fibroblasts
    512. Cathepsin cleavage of sirtuin 1 in endothelial progenitor cells mediates stress-induced premature senescence
    513. Causes and Controlling Measures of Cotton Premature Senescence in Yangtze River Cotton Area [J]
    514. Caveolin‐1 deficiency induces premature senescence with mitochondrial dysfunction
    515. Caveolin-1 expression and stress-induced premature senescence in human intervertebral disc degeneration
    516. Caveolin-1 mediated p53 activation in stress induced premature senescence and its antagonistic pleiotropic implications in cancer
    517. CBX8 antagonizes the effect of Sirtinol on premature senescence through the AKT-RB-E2F1 pathway in K562 leukemia cells
    518. CBX8 suppresses Sirtinol-induced premature senescence in human breast cancer cells via cooperation with SIRT1
    519. CD34+ cells from patients with myelodysplastic syndrome present different p21 dependent premature senescence
    520. Cell cycle arrest by human cytomegalovirus 86-kDa IE2 protein resembles premature senescence
    521. Cell cycle regulation in H2O2-induced premature senescence of human diploid fibroblasts and regulatory control exerted by the papilloma virusE6 and E7 proteins
    522. Cell proliferation and amplifies long‐term temozolomide‐and radiation‐induced cytotoxicity in melanoma cells: A role for autophagy and premature senescence
    523. Cell-Free Culture Supernatant of Probiotic Lactobacillus fermentum Protects Against H2O2-Induced Premature Senescence by Suppressing ROS-Akt-mTOR Axis in …
    524. Cells deleted for Brca2 COOH terminus exhibit hypersensitivity to γ-radiation and premature senescence
    525. Cellular and molecular mechanisms of stress-induced premature senescence (SIPS) of human diploid fibroblasts and melanocytes
    526. Cellular Senescence and Premature Aging in Lung Diseases
    527. Cellular senescence in normal and premature lung aging
    528. Changes in levels of foliar carbohydrates and myo-inositol before premature leaf senescence of Populus nigra induced by a mixture of O3 and SO2
    529. Changes of the expression for genes related with senescence and the telomerase activity during cellular replicative and premature senescence in human embryonic …
    530. Characterization and fine mapping of the rice premature senescence mutant ospse1
    531. Characterization and fine-mapping of a novel premature leaf senescence mutant yellow leaf and dwarf 1 in rice
    532. Characterization and Mapping of a Novel Premature Leaf Senescence Mutant in Common Tobacco (Nicotiana tabacum L.)
    533. Chromosome aberrations and cellular premature senescence as radiation-induced sub-lethal effects: Implications for laser-driven charged-particle radiotherapy
    534. Chronic low dose rate ionizing radiation exposure induces premature senescence in human fibroblasts that correlates with up regulation of proteins involved in …
    535. Chronic NF-κB activation delays RasV12-induced premature senescence of human fibroblasts by suppressing the DNA damage checkpoint response
    536. Chronic Nucleoside Reverse Transcriptase Inhibitors Disrupt Mitochondrial Homeostasis and Promote Premature Endothelial Senescence
    537. Cilostazol inhibits oxidative stress–induced premature senescence via upregulation of Sirt1 in human endothelial cells
    538. Circular RNA expression profile in human fibroblast premature senescence after repeated ultraviolet B irradiations revealed by microarray
    539. Cisplatin-induced premature senescence with concomitant reduction of gap junctions in human fibroblasts
    540. c-Jun-deficient cells undergo premature senescence as a result of spontaneous DNA damage accumulation
    541. Coenzyme Q10 Alleviates Chronic Nucleoside Reverse Transcriptase Inhibitor-Induced Premature Endothelial Senescence
    542. Cofilin mediates actin destabilization and shape change in replicative senescence and stress-induced premature senescence
    543. Colonization of durum wheat (Triticum turgidum L. var. durum) culms exhibiting premature senescence (dead heads) associated with Fusarium pseudograminearum …
    544. Comparison of global DNA methylation profiles in replicative versus premature senescence
    545. Comparison of replicative senescence and stress‐induced premature senescence combining differential display and low‐density DNA arrays
    546. Comparison of the effects of 40% oxygen and two atmospheric absolute air pressure conditions on stress-induced premature senescence of normal human diploid …
    547. Comprehensive Evaluation of Soil Fertility in Premature Senescence Cotton Fields in the Yellow River Region
    548. Compromising the constitutive p16INK4a expression sensitizes human neuroblastoma cells to Hsp90 inhibition and promotes premature senescence
    549. Conditioned medium derived from human amniotic stem cells delays H2O2‑induced premature senescence in human dermal fibroblasts
    550. Constitutive Activation of rac1 Results in Mitochondrial Oxidative Stress and Induces Premature Endothelial Cell Senescence
    551. Contribution of mitochondrial dysfunction and oxidative stress to cellular premature senescence induced by antiretroviral thymidine analogues
    552. Contribution of p16INK4a and p21CIP1 pathways to induction of premature senescence of human endothelial cells: permissive role of p53
    553. Control of premature senescence for the high and stable output of cotton.
    554. Cooperative role between p21cip1/waf1 and p27kip1 in premature senescence in glandular proliferative lesions in mice
    555. Copper ability to induce premature senescence in human fibroblasts
    556. Cordyceps militaris extract protects human dermal fibroblasts against oxidative stress-induced apoptosis and premature senescence
    557. Co-regulation of p16INK4A and migratory genes in culture conditions that lead to premature senescence in human keratinocytes
    558. Correction: Adiponectin Suppresses UVB-Induced Premature Senescence and hBD2 Overexpression in Human Keratinocytes
    559. Correlation between senescence and DNA repair in cells from young and old individuals and in premature aging syndromes
    560. Corrigendum to’Autophagic cell death and premature senescence: New mechanism of 5-fluorouracil and sulforaphane synergistic anticancer effect in MDA-MB-231 …
    561. Cr (VI) induces premature senescence through ROS-mediated p53 pathway in L-02 hepatocytes
    562. Cristacarpin promotes ER stress-mediated ROS generation leading to premature senescence by activation of p21waf-1
    563. Curcumin attenuates hydrogen peroxide-induced premature senescence via the activation of SIRT1 in human umbilical vein endothelial cells
    564. Cyclic mechanical tension reinforces DNA damage and activates the p53-p21-Rb pathway to induce premature senescence of nucleus pulposus cells
    565. Cyclophosphamide induces premature senescence in normal human fibroblasts by activating MAP kinases
    566. Cytokinesis defects, polyploidy and premature senescence in SSeCKS/Gravin/AKAP12-null mouse embryo fibroblasts
    567. Cytoplasmic Retention of CDC6 Induces Premature Senescence in Immortalized Cells and Suppresses Tumor Formation in Mice
    568. Damaged DNA binding protein 2 in reactive oxygen species (ROS) regulation and premature senescence
    569. Davallialactone from mushroom reduced premature senescence and inflammation on glucose oxidative stress in human diploid fibroblast cells
    570. DDB2, an essential mediator of premature senescence
    571. DEC1, a basic helix-loop-helix transcription factor and a novel target gene of the p53 family, mediates p53-dependent premature senescence
    572. Deconstructing PML‐induced premature senescence
    573. Deficient autophagy induces premature senescence in aging and osteoarthritis
    574. Depletion of CSN5 inhibits Ras-mediated tumorigenesis by inducing premature senescence in p53-null cells
    575. Deregulation of hsa-miR-20b expression in TNF-α-induced premature senescence of human pulmonary microvascular endothelial cells
    576. D-galactose induces premature senescence of lens epithelial cells by disturbing autophagy flux and mitochondrial functions
    577. Diagnosis of premature senescence of cotton using SPAD value
    578. Differences in protein changes between stress‐induced premature senescence and replicative senescence states
    579. Differential protein expression in senescent human skin fibroblasts and stress induced premature senescence (SIPS) fibroblasts
    580. Diperoxovanadate can substitute for H2O2 at much lower concentration in inducing features of premature cellular senescence in mouse fibroblasts (NIH3T3)
    581. Discussion on Premature Senescence of Maize and Its Prevention Technology [J]
    582. Disorazole C1: A potent antimitotic agent that induces premature senescence
    583. Disruption of a Upf1-like helicase-encoding gene OsPLS2 triggers light-dependent premature leaf senescence in rice
    584. Dissecting the Regulatory Network of Leaf Premature Senescence in Maize (Zea mays L.) Using Transcriptome Analysis of ZmELS5 Mutant
    585. DNA deletion and impairment of mitochondrial biogenesis are mediated by reactive oxygen species in ionizing radiation-induced premature senescence
    586. Dominant Gene cplsr1 Corresponding to Premature Leaf Senescence Resistance in Cotton (Gossypium hirsutum L.)F
    587. Down regulation of CD147 boosts the premature senescence in human skin fibroblasts by destroying the redox balance and inhibiting klotho
    588. Down-regulation and decreased activity of cyclin-dependent kinase 2 in H2O2-induced premature senescence
    589. Down-regulation of Asymmetric Arginine Methylation During Replicative and H2O2-induced Premature Senescence in WI-38 Human Diploid Fibroblasts
    590. DP 4.08 P16 triggers premature senescence of congenital DM1 myoblasts
    591. Drug-induced premature senescence model in human dental follicle stem cells
    592. Dysfunction during Aging and Senescence: Effect of lipopolysaccharides on adipogenic potential and premature senescence of adipocyte progenitors
    593. Early loss of proliferative potential of human peritoneal mesothelial cells in culture: the role of p16INK4a-mediated premature senescence
    594. Effect of bisphenol A on stress-induced premature senescence
    595. Effect of lipopolysaccharides on adipogenic potential and premature senescence of adipocyte progenitors
    596. EFFECT OF MAGNETIC FIELD AND NANO-PARTICLES OFTITANIUM OXIDE (TIO2) ON SEED GERMINATION AND EARLYGROWTH CHARACTERISTICS OF AJOWAN (AMMI COPTICUM L.) IN PREMATURE SENESCENCE
    597. Effect of Maize Straw Return to Soil on Premature Senescence [J]
    598. Effect of rapamycin on high glucose-induced autophagy impairment, oxidative stress and premature senescence in rat mesangial cells in vitro
    599. Effect of removal of basal fruiting branches on some premature senescence characters of different cotton genotypes.
    600. Effect of removal of early squares on verticillium wilt and premature senescence in Bt transgenic cotton
    601. Effect of Saikokeishito, a Kampo medicine, on hydrogen peroxide-induced premature senescence of normal human dermal fibroblasts
    602. Effect of sulfated galactan from Porphyra haitanensis on H2O2-induced premature senescence in WI-38 cells
    603. Effect of water stress and nutrition stress on premature senescence-related enzyme activity in harvested broccoli
    604. Effects of Early Fruiting Branch Removal on Physiological Traits of Leaves Related to Premature Senescence, Yield, and Fiber Quality of Transgenic Bt Cotton
    605. Effects of estrogen on stress-induced premature senescence of vascular smooth muscle cells: a novel mechanism for the “time window theory” of menopausal …
    606. Effects of ginsenoside and Lycium barbarum polysaccharide on UVB irradiation-induced premature senescence of skin fibroblasts.
    607. Effects of Potassium Oligosaccharide Acids Effervescent Tablet on Premature Senescence and Yield of Wheat [J]
    608. Effects of removal of early fruiting branches on yield, fiber quality and premature senescence in Bt transgenic cotton
    609. Effects of sirolimus on ultraviolet B irradiation-induced premature senescence of skin fibroblasts
    610. Effects of the estrogen receptor on stress-induced premature senescence of vascular smooth muscle cells in vitro
    611. eIF2α phosphorylation bypasses premature senescence caused by oxidative stress and pro-oxidant antitumor therapies
    612. Elimination of protein aggregates prevents premature senescence in human trisomy 21 fibroblasts
    613. Endogenous transmembrane TNF-alpha protects against premature senescence in endothelial colony forming cells
    614. Enhanced elimination of oxidized guanine nucleotides inhibits oncogenic RAS-induced DNA damage and premature senescence
    615. Epigallocatechin gallate suppresses premature senescence of preadipocytes by inhibition of PI3K/Akt/mTOR pathway and induces senescent cell death by regulation …
    616. Epigenetic enhancement of p66Shc during cellular replicative or premature senescence
    617. Erratum. Adiponectin Prevents Diabetic Premature Senescence of Endothelial Progenitor Cells and Promotes Endothelial Repair by Suppressing the p38 MAP Kinase …
    618. Escape from premature senescence is not sufficient for oncogenic transformation by Ras
    619. Escherichia coli producing colibactin triggers premature and transmissible senescence in mammalian cells
    620. Essential role for premature senescence of myofibroblasts in myocardial fibrosis
    621. Establishment of H2O2‐Induced Premature Senescence in Human Fibroblasts Concomitant with Increased Cellular Production of H2O2
    622. Ethylene production and premature senescence of needles from fir trees (Abies alba)
    623. Evaluation of premature senescence and senescence biomarkers in carcinoma cells and xenograft mice exposed to single or fractionated irradiation
    624. Evidence that premature senescence affects photosynthetic decline of wheat flag leaves during growth in elevated carbon dioxide
    625. Exploiting “oncogene addiction” and “premature senescence” to design novel therapeutic strategies for the treatment of cancer
    626. Exposure to polycyclic aromatic hydrocarbons derived from vehicle exhaust gas induces premature senescence in mouse lung fibroblast cells
    627. Expression of catalytically active telomerase does not prevent premature senescence caused by overexpression of oncogenic Ha-Ras in normal human fibroblasts
    628. Expression of Clusterin suppresses Cr (VI)-induced premature senescence through activation of PI3K/AKT pathway
    629. Expression of senescence-associated miR-34c and SIRT1 in premature senescence of human skin fibroblasts induced by ultraviolet B
    630. Expression of β-catenin in oxidative stress-induced premature senescence of human skin fibroblasts
    631. Extension of Life Span and Delay of Stress–Induced Premature Senescence of Trabecular Meshwork (TM) Cells Incubated at Low Oxygen Tension
    632. FGFR3 signaling induces a reversible senescence phenotype in chondrocytes similar to oncogene-induced premature senescence
    633. Fibroblast growth factor 21 delayed endothelial replicative senescence and protected cells from H2O2-induced premature senescence through SIRT1
    634. Fibroblast Stimulation of Blood Vessel Development and Cancer Cell Invasion in a Subrenal Capsule Xenograft Model: Stress-Induced Premature Senescence Does Not Increase Effect1
    635. FP258 VNN1 mediates renal maladaptive repair after AKI by inducing premature senescence of renal tubular cells
    636. From the Hayflick mosaic to the mosaics of ageing.: Role of stress-induced premature senescence in human ageing
    637. Fullerene derivatives induce premature senescence: A new toxicity paradigm or novel biomedical applications
    638. Fullerenol Protects Human Retinal Pigment Epithelial Cells from Oxidative-Stress-Induced Premature Senescence Model in vitro
    639. Fullerenol protects retinal pigment epithelial cells from oxidative stress–induced premature senescence via activating SIRT1
    640. Fullerenol Protects RPE cells from Oxidative-stress Induced Premature Senescence via Activation of SIRT1
    641. Gadd45b deficiency impairs G2/M cell cycle progression leading to premature senescence
    642. Gadd45b deficiency promotes premature senescence and skin aging
    643. Gardenia jasminoides extract-capped gold nanoparticles reverse hydrogen peroxide-induced premature senescence
    644. Gefitinib induces premature senescence in non-small cell lung cancer cells with or without EGFR gene mutation
    645. Gene expression and regulation in H2O2-induced premature senescence of human foreskin fibroblasts expressing or not telomerase
    646. Gene mapping of starch accumulation and premature leaf senescence in the ossac3 mutant of rice
    647. Genetic analysis and fine mapping of a premature leaf senescence mutant in rice (Orzya sativa L.).
    648. Genetic analysis and high-resolution mapping of a premature senescence gene Pse(t) in rice (Oryza sativa L.)
    649. Genetic analysis of biochemical traits in short season upland cotton with no premature senescence
    650. Genetic and physio-biochemical characterization of a novel premature senescence leaf mutant in rice (Oryza sativa L.)
    651. Genetic diseases of premature aging as models of senescence
    652. Genetic effects and diagnosis of premature senescence of leaf in upland cotton.
    653. Ginsenoside Rg1 attenuates Busulfan-induced premature senescence
    654. Ginsenoside Rg1 delays tert-butyl hydroperoxide-induced premature senescence in human WI-38 diploid fibroblast cells
    655. Ginsenoside Rg1 protects human fibroblasts against psoralen-and UVA-induced premature senescence through a telomeric mechanism
    656. Glucosamine attenuates hydrogen peroxide-induced premature senescence in human retinal pigment epithelial cells in vitro
    657. Glucose utilization via glycogen phosphorylase sustains proliferation and prevents premature senescence in cancer cells
    658. Glutathione depletion induces ferroptosis, autophagy, and premature cell senescence in retinal pigment epithelial cells
    659. Glycated collagen I induces premature senescence-like phenotypic changes in endothelial cells
    660. Glyoxal‐induced premature senescence in human fibroblasts
    661. GP 9 04 Premature senescence of myoblasts in oculopharyngeal muscular dystrophy
    662. Growth kinetics rather than stress accelerate telomere shortening in cultures of human diploid fibroblasts in oxidative stress‐induced premature senescence
    663. Guiqi polysaccharide protects the normal human fetal lung fibroblast WI-38 cells from H2O2-induced premature senescence
    664. GW24-e0410 Stress-induced premature senescence in primary human umbilical vein endothelial cells
    665. GW25-e2369 Lipoic acid inhibits oxidative stress-induced premature senescence via upregulation of Sirt1 in human umbilical vascular endothelial cells
    666. GW25-e4428 Exogenous Hydrogen Sulfide Delays Nicotinamide-Induced Premature Senescence via SIRT1 pathway in Human Umbilical Vein Endothelial Cells
    667. Haploinsufficiency for BRCA1 leads to cell-type-specific genomic instability and premature senescence
    668. Heat shock induces apoptosis in human embryonic stem cells but a premature senescence phenotype in their differentiated progeny
    669. Helicobacter pylori-induced premature senescence of extragastric cells may contribute to chronic skin diseases
    670. Heme oxygenase-1 and interleukin-11 are overexpressed in stress-induced premature senescence of human WI-38 fibroblasts induced by tert-butylhydroperoxide …
    671. Hepatitis B virus X protein overcomes stress-induced premature senescence by repressing p16INK4a expression via DNA methylation
    672. Hepatitis C virus Core protein overcomes stress-induced premature senescence by down-regulating p16 expression via DNA methylation
    673. HEREDITARY PREMATURE SENESCENCE OF THE RABBIT I. CHROmC FOR~; G~ m~ RAL FEATURES
    674. Hereditary premature senescence of the rabbit: I. Chronic form; general features
    675. HEREDITARY PREMATURE SENESCENCE OF THE RABBIT: II. ACUTE FORM; GENERAL FEATURES
    676. Heterogeneity in premature senescence by oxidative stress correlates with differential DNA damage during the cell cycle
    677. HIF1α delays premature senescence through the activation of MIF
    678. High doses of synthetic antioxidants induce premature senescence in cultivated mesenchymal stem cells
    679. High intensity ras signaling induces premature senescence by activating p38 pathway in primary human fibroblasts
    680. High-magnitude compression accelerates the premature senescence of nucleus pulposus cells via the p38 MAPK-ROS pathway
    681. Histological evidence of oxidative stress and premature senescence in preterm premature rupture of the human fetal membranes recapitulated in vitro
    682. Histone H4 lysine 16 hypoacetylation is associated with defective DNA repair and premature senescence in Zmpste24-deficient mice
    683. Histone modifications contribute to cellular replicative and hydrogen peroxide-induced premature senescence in human embryonic lung fibroblasts
    684. HIV antiretroviral therapy drugs induce premature senescence and altered physiology in HUVECs
    685. Human electronegative LDL induces mitochondrial dysfunction and premature senescence of vascular cells in vivo
    686. Human fibroblast cells are resistant to low levels of DNA double-strand break induced apoptosis and subsequently undergo drug-induced premature senescence
    687. Human lipodystrophies linked to mutations in A-type lamins and to HIV protease inhibitor therapy are both associated with prelamin A accumulation, oxidative …
    688. Human umbilical cord-derived mesenchymal stromal cells protect against premature renal senescence resulting from oxidative stress in rats with acute kidney …
    689. Hydrogen sulfide delays nicotinamide-induced premature senescence via upregulation of SIRT1 in human umbilical vein endothelial cells
    690. Hyperoxia-induced premature senescence requires p53 and pRb, but not mitochondrial matrix ROS
    691. Hypoxia reoxygenation induces premature senescence in neonatal SD rat cardiomyocytes1
    692. Identification and characterization of secretory proteins during ionizing radiation-induced premature senescence
    693. Identification and comparative analysis of premature senescence leaf mutants in rice (Oryza sativa L.)
    694. Identification of 30 protein species involved in replicative senescence and stress‐induced premature senescence
    695. Identification of a novel E3 ubiquitin ligase that is required for suppression of premature senescence in Arabidopsis
    696. Identification of p38MAPK-dependent genes with changed transcript abundance in H2O2-induced premature senescence of IMR-90 hTERT human fibroblasts
    697. Identification of p53-dependent genes potentially involved in UVB-mediated premature senescence of human skin fibroblasts using siRNA technology
    698. Identification of Premature Senescence Cells in the Brain of the HIV-1 Transgenic Rat (HIV-TG Rat)
    699. IGF-1 rescues human intervertebral annulus cells from in vitro stress-induced premature senescence
    700. IGF-1 Rescues Human Intervertebral Annulus Cells in a Novel Model of in Vitro Stress-Induced Premature Senescence: Paper# 19.
    701. IL-6-STAT3 signaling and premature senescence
    702. Impact of ER stress-regulated ATF4/p16 signaling on the premature senescence of renal tubular epithelial cells in diabetic nephropathy
    703. Impact of ozone on the activity and quantity of ribulose bisphosphate carboxylase/oxygenase in potato foliage and its relation to premature senescence.
    704. Impact of premature senescence on radiosensitivity measured by high throughput cell-based assays
    705. In memoriam Olivier Toussaint–Stress-induced premature senescence and the role of DNA damage
    706. Increased abundance of cytoplasmic and nuclear caveolin 1 in human diploid fibroblasts in H2O2-induced premature senescence and interplay with …
    707. Increased chemo-sensitivity by knockdown coilin expression involved acceleration of premature cellular senescence in HeLa cells
    708. Increasing the complexity of respiratory syncytial virus infection: Reactive oxygen species, DNA damage, and premature senescence
    709. Induction of EMT by twist proteins as a collateral effect of tumor-promoting inactivation of premature senescence
    710. Induction of premature senescence by hsp90 inhibition in small cell lung cancer
    711. Induction of premature senescence by single and fractionated irradiation in human cancer cell line and xenografted mice model
    712. Induction of premature senescence in cardiomyocytes by doxorubicin as a novel mechanism of myocardial damage
    713. Induction of premature senescence in cardiomyocytes by oxidative stress as a novel mechanism of myocardial dysfunction
    714. Induction of premature senescence in human fibroblasts through endoplasmic reticulum stress: protection by phenolic diterpenes
    715. Induction of premature senescence in human lung cancer by fungal immunomodulatory protein from Ganoderma tsugae
    716. Induction of premature senescence program by an inhibitor of histone deacetylase sodium butyrate in normal and transformed rat fibroblasts
    717. Induction of stress induced premature senescence by sirtuin-7 inhibition: a novel mechanism for multi drug resistance
    718. Inflammatory cytokine TNF-α promotes premature senescence of rat nucleus pulposus cells through PI3K/Akt signaling pathway
    719. Influence of RNA interference in p53 gene on the expressions of genes involved in ultraviolet B-induced premature senescence and photocarcinogenesis in human …
    720. Inhibition of nuclear factor-erythroid 2–related factor (Nrf2) by caveolin-1 promotes stress-induced premature senescence
    721. Inhibition of stress induced premature senescence in presenilin-1 2 mutated cells with water soluble Coenzyme Q10 Q2
    722. Inhibition of stress induced premature senescence in presenilin-1 mutated cells with water soluble Coenzyme Q10
    723. Inhibition of the K+ Channel KCa3. 1 Reduces TGF-b1-Induced Premature Senescence
    724. Inhibition of the K+ Channel KCa3. 1 Reduces TGF-β1-Induced Premature Senescence, Myofibroblast Phenotype Transition and Proliferation of Mesangial Cells
    725. Inhibition of thioredoxin reductase 1 by caveolin 1 promotes stress‐induced premature senescence
    726. Inhibition of Twist1-mediated invasion by Chk2 promotes premature senescence in p53-defective cancer cells
    727. Inhibition of vascular smooth muscle cells premature senescence with rutin attenuates and stabilizes diabetic atherosclerosis
    728. Initiation of premature senescence by Bcl-2 in hypoxic condition
    729. Inonotus obliquus protects against oxidative stress-induced apoptosis and premature senescence
    730. Ins and outs of tumour control: when a potentially dangerous cell can’t be repaired, it must be either stopped or killed. Premature senescence of cancerous cells is one …
    731. Insulin-like growth factor binding proteins 4 and 7 released by senescent cells promote premature senescence in mesenchymal stem cells
    732. Insulin-like growth factor-1 attenuates oxidative stress-induced hepatocyte premature senescence in liver fibrogenesis via regulating nuclear p53–progerin …
    733. Interaction of nematodes with Fusarium moniliforme, incitant of premature senescence of maize
    734. Interleukin-1β induced premature senescence of articular chondrocytes
    735. Interleukin-6 Induces Premature Senescence Involving Signal Transducer and Activator of Transcription 3 and Insulin-Like Growth Factor-Binding Protein 5
    736. Intestinal stem cells acquire premature senescence and senescence associated secretory phenotype concurrent with persistent DNA damage after heavy ion …
    737. Investigation of premature senescence and red leaf occurrence in different cotton varieties.
    738. Involvement of abscisic acid in PSII photodamage and D1 protein turnover for light-induced premature senescence of rice flag leaves
    739. Involvement of MAP-kinase cascades in regulation of sodium-butyrate-induced premature senescence
    740. Involvement of MAP-kinase cascades into the regulation of sodium butyrate induced premature cell senescence
    741. Ionizing irradiation inhibits keloid fibroblast cell proliferation and induces premature cellular senescence
    742. Ionizing radiation and busulfan induce premature senescence in murine bone marrow hematopoietic cells
    743. Ionizing radiation-mediated premature senescence and paracrine interactions with cancer cells enhance the expression of syndecan 1 in human breast …
    744. Is post-traumatic stress disorder associated with premature senescence? A review of the literature
    745. Isolation and physiological characteristics of a premature senescence mutant in rice (Oryza sativa L.)
    746. JNK inhibition sensitizes tumor cells to radiation-induced premature senescence via Bcl-2/ROS/DDR signaling pathway
    747. Klotho RNAi induces premature senescence of human cells via a p53/p21 dependent pathway
    748. Knockdown of IL-8 Provoked Premature Senescence of Placenta-Derived Mesenchymal Stem Cells
    749. Knocking out the gene RLS1 induces hypersensitivity to oxidative stress and premature leaf senescence in rice
    750. Lack of vitamin D receptor causes stress-induced premature senescence in vascular smooth muscle cells through enhanced local angiotensin-II signals
    751. Large CTG repeats trigger p16-dependent premature senescence in myotonic dystrophy type 1 muscle precursor cells
    752. Lipid mediators of autophagy in stress-induced premature senescence of endothelial cells
    753. Long noncoding RNA H19 mediates melatonin inhibition of premature senescence of c‐kit+ cardiac progenitor cells by promoting miR‐675
    754. Long-term arsenite exposure induces premature senescence in B cell lymphoma A20 cells
    755. Long-term exposure to TNF-α leads human skin fibroblasts to a p38 MAPK-and ROS-mediated premature senescence
    756. Losartan inhibits STAT1 activation and protects human glomerular mesangial cells from angiotensin II induced premature senescence
    757. Loss of Cdh1 Triggers Premature Senescence in Part via Activation of Both the RB/E2F1 and the CLASPIN/CHK1/P53 Tumor Suppressor Pathways
    758. LPS-induced premature osteocyte senescence: Implications in inflammatory alveolar bone loss and periodontal disease pathogenesis
    759. Lutein suppresses hyperglycemia‐induced premature senescence of retinal pigment epithelial cells by upregulating SIRT1
    760. MAD2 depletion triggers premature cellular senescence in human primary fibroblasts by activating a p53 pathway preventing aneuploid cells propagation
    761. Malvidin protects WI-38 human fibroblast cells against stress-induced premature senescence
    762. Management practices to control premature senescence in Bt cotton
    763. Mapping mechanisms and charting the time course of premature cell senescence and apoptosis: lysosomal dysfunction and ganglioside accumulation in endothelial …
    764. Mapping of post-flowering drought resistance traits in grain sorghum: association between QTLs influencing premature senescence and maturity
    765. Mapping QTL for drought stress-induced premature senescence and maturity in cowpea [Vigna unguiculata (L.) Walp.]
    766. Maternal Characteristics versus Egg Size and Energy Density: Do Stocked Lake Trout in Lake Ontario Experience Premature Reproductive Senescence?
    767. Measurements of hydrogen peroxide induced premature senescence: senescence-associated β-galactosidase and DNA synthesis index in human diploid fibroblasts …
    768. Mechanism of premature senescence of cotton plants grown under drip irrigation and mulch film: plant growth response and nutrient status.
    769. Mechanism of radiation induced premature senescence of bone marrow stromal cells: experiment with murine bone marrow stromal cells
    770. Mechanisms of premature cell senescence
    771. Meiotic drive by the Y-linked D gene in Aedes aegypti (L.)(Diptera: Culicidae) is associated with disruption of spermiogenesis, leading to premature senescence of …
    772. Melatonin reverses H2O2‐induced premature senescence in mesenchymal stem cells via the SIRT1‐dependent pathway
    773. Melatonin suppresses doxorubicin‐induced premature senescence of A549 lung cancer cells by ameliorating mitochondrial dysfunction
    774. Mesenchymal stem cells from rats with chronic kidney disease exhibit premature senescence and loss of regenerative potential
    775. Meteorological Conditions and Countermeasures for Premature Senescence of Insect-Resistant Cotton [J]
    776. Microparticles released by senescent endothelial cells promote premature endothelial senescence associated with an impaired NO formation and oxidative …
    777. MicroRNA regulation of ionizing radiation-induced premature senescence
    778. MicroRNA-34a (miR-34a) Mediates Retinal Endothelial Cell Premature Senescence through Mitochondrial Dysfunction and Loss of Antioxidant Activities
    779. Microtubule binding and disruption and induction of premature senescence by disorazole C1
    780. Mild mitochondrial uncoupling prevents premature senescence in human dermal fibroblasts
    781. MiR-23a-depressed autophagy is a participant in PUVA-and UVB-induced premature senescence
    782. Mitochondrial DNA deletion and impairment of mitochondrial biogenesis by reactive oxygen species in ionizing radiation-induced premature senescence
    783. Mitoxantrone ability to induce premature senescence in human dental pulp stem cells and human dermal fibroblasts
    784. MMP-9 inhibition provokes premature senescence resulting in inhibition of medulloblastoma tumor growth via p16 INK4A and mitogen-activated protein kinase …
    785. Modelling human ageing: Role of telomeres in stress-induced premature senescence and design of anti-ageing strategies
    786. Modulation of PPARγ provides new insights in a stress induced premature senescence model
    787. Molecular basis for premature senescence induced by surfactants in normal human cells
    788. Molecular biomarkers indicate precocious in vitro senescence in fibroblasts from SAMP6 mice: evidence supporting a murine model of premature senescence …
    789. Molecular mechanisms of premature senescence in cotton
    790. Molecular models of aging: comparative analysis of gene signatures in replicative senescence and stress induced premature senescence
    791. Monoamine oxidase‐A is a novel driver of stress‐induced premature senescence through inhibition of parkin‐mediated mitophagy
    792. MOZ increases p53 acetylation and premature senescence through its complex formation with PML
    793. Mussel oligopeptides protect human fibroblasts from hydrogen peroxide (H2O2)-induced premature senescence
    794. NaDC3 induces premature cellular senescence by promoting transport of krebs cycle intermediates, increasing NADH, and exacerbating oxidative damage
    795. NADPH oxidase NOX1 is involved in activation of protein kinase C and premature senescence in early stage diabetic kidney
    796. NCOA4 depletion leads to replication stress and premature senescence
    797. Nek6 suppresses the premature senescence of human cancer cells induced by camptothecin and doxorubicin treatment
    798. Nevirapine induces growth arrest and premature senescence in human cervical carcinoma cells
    799. Nijmegen breakage syndrome fibroblasts expressing the C-terminal truncated NBNp70 protein undergo p38/MK2-dependent premature senescence
    800. Not Affect the Overexpression of p21WAF‐1 after Exposure of IMR‐90 hTERT Fibroblasts to a Sublethal Concentration of H2O2 Leading to Premature Senescence
    801. Novel contributors and mechanisms of cellular senescence in hypertension-associated premature vascular aging
    802. Novel mechanisms of sublethal oxidant toxicity: induction of premature senescence in human fibroblasts confers tumor promoter activity
    803. Nuclear swelling occurs during premature senescence mediated by MAP kinases in normal human fibroblasts
    804. Obesity and type-2 diabetes as inducers of premature cellular senescence and ageing
    805. Occludin‐mediated premature senescence is a fail‐safe mechanism against tumorigenesis in breast carcinoma cells
    806. Ochratoxin A induced premature senescence in human renal proximal tubular cells
    807. Oct4 suppresses IR‑induced premature senescence in breast cancer cells through STAT3-and NF‑κB-mediated IL‑24 production
    808. Oncogenic ras induces premature senescence in endothelial cells: role of p21Cip1/Waf1
    809. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
    810. Osthole Delays Tert-Butyl Hydroperoxide-Induced Premature Senescence in Neural Stem Cells
    811. Overactive Arginase Causes Mitochondrial Dysfunction and Premature Endothelial Cell Senescence during Diabetic Retinopathy
    812. Overexpression of apolipoprotein J in human fibroblasts protects against cytotoxicity and premature senescence induced by ethanol and tert …
    813. Overexpression of CHMP7 from rapeseed and Arabidopsis causes dwarfism and premature senescence in Arabidopsis
    814. Overexpression of SIRT6 in porcine fetal fibroblasts attenuates cytotoxicity and premature senescence caused by D-galactose and tert-butylhydroperoxide
    815. Oxidative DNA damage causes premature senescence in mouse embryonic fibroblasts deficient for Krüppel‐like factor 4
    816. Oxidative stress and premature senescence in corneal endothelium following penetrating keratoplasty in an animal model
    817. Oxidative stress induces premature senescence by stimulating caveolin-1 gene transcription through p38 mitogen-activated protein kinase/Sp1–mediated activation of …
    818. Oxidative stress-induced inhibition of Sirt1 by caveolin-1 promotes p53-dependent premature senescence and stimulates the secretion of interleukin 6 (IL-6)
    819. Oxidative stress-induced premature senescence dysregulates VEGF and CFH expression in retinal pigment epithelial cells: implications for age-related …
    820. Oxidative stress-induced premature senescence in Wharton’s jelly-derived mesenchymal stem cells
    821. OXIDIZED LDL INDUCES STRESS-INDUCED PREMATURE SENESCENCE IN CULTURED BOVINE ARTICULAR CHONDROCYTES
    822. Oxygen-sensing Nox4 generates genotoxic ROS to induce premature senescence of nucleus pulposus cells through MAPK and NF-κB pathways
    823. P. 106 Thrombospondin 1 mediates transforming growth factor beta induced premature senescence in primary glioblastoma cells
    824. P16 INK4a Deletion Ameliorated Renal Tubulointerstitial Injury in a Stress-induced Premature Senescence Model of Bmi-1 Deficiency
    825. P161: Adiponectin suppresses UVB-induced premature senescence and hBD2 overexpression by blocking p38, JNK/SAPK MAPK signaling in human normal …
    826. P196: Adiponectin ameliorate cellular premature senescence and restitute abnormal increase of antimicrobial peptide level in senescent keratinocyte
    827. P2-03-05: Attenuation of TGF-beta Signaling Suppresses Premature Senescence in a p21-Dependent Manner and Promotes Oncogenic ras-Mediated Metastatic …
    828. p21 WAF1 and hypoxia/reoxygenation-induced premature senescence of H9c2 cardiomyocytes
    829. p41-Arc, a regulatory subunit of Arp2/3 complex, can induce premature senescence in the absence of p53 and Rb
    830. p53 and ATF-2 partly mediate the overexpression of COX-2 in H2O2-induced premature senescence of human fibroblasts
    831. Paeonol protects against premature senescence in endothelial cells by modulating Sirtuin 1 pathway
    832. Pak4 induces premature senescence via a pathway requiring p16INK4/p19ARF and mitogen-activated protein kinase signaling
    833. Partial uncoupling of oxidative phosphorylation induces premature senescence in human fibroblasts and yeast mother cells
    834. Pathways of aging: comparative analysis of gene signatures in replicative senescence and stress induced premature senescence
    835. Pegylated IFN-α sensitizes melanoma cells to chemotherapy and causes premature senescence in endothelial cells by IRF-1-mediated signaling
    836. Performance and Mechanisms of Premature Senescence in Cotton
    837. Persistent DNA damage-induced premature senescence alters the functional features of human bone marrow mesenchymal stem cells
    838. Persistent DNA damage‐induced premature senescence alters the functional features of human bone marrow mesenchymal stem cells
    839. PFG acted as an inducer of premature senescence in TIG-1 normal diploid fibroblast and an inhibitor of mitosis in the HeLa cells
    840. Pharmacological DNA-PK inhibition induces ATM/p53 dependent premature senescence with immunomodulatory phenotype in irradiated cancer cells
    841. Phenotypic characterization and fine mapping of mps1, a premature leaf senescence mutant in rice (Oryza sativa L.)
    842. Photosynthesis and chloroplast ultra-structure characteristics of flag leaves for a premature senescence rice mutant.
    843. PHYSIOLOGICAL PARAMETERS IN RELATION TO PREMATURE SENESCENCE IN WINTER WHEAT (TRITICUM AESTIVUM)[J]
    844. Placental telomere shortening in stillbirth: a sign of premature senescence?
    845. PML is induced by oncogenic ras and promotes premature senescence
    846. PML regulates p53 acetylation and premature senescence induced by oncogenic Ras
    847. Polymerase I and transcript release factor (PTRF)/cavin-1 is a novel regulator of stress-induced premature senescence
    848. PPM1B depletion induces premature senescence in human IMR-90 fibroblasts
    849. Prelamin A accumulation in endothelial cells induces premature senescence and functional impairment
    850. Prelamin a accumulation induced by hiv protease inhibitors or lamin a mutations triggers premature senescence and calcification of vascular smooth muscle cells
    851. Prelamin accumulation in primary endothelial cells induces premature senescence and activation
    852. Preliminary Study on Identification Indexes of the Anti-premature Senescence at Wheat Seed Germination Stage
    853. Premature aging/senescence in cancer cells facing therapy: good or bad?
    854. Premature B-cell senescence as a consequence of chronic immune activation: Implications for vaccination of immune compromised individuals
    855. Premature cardiac senescence in DahlS. Z-Leprfa/Leprfa rats as a new animal model of metabolic syndrome
    856. Premature cell senescence in human skin: dual face in chronic acquired pigmentary disorders
    857. Premature cellular senescence induced by pyocyanin, a redox-active Pseudomonas aeruginosa toxin
    858. Premature immune senescence in children with MS: Too young to go steady
    859. Premature leaf senescence 3, encoding a methyltransferase, is required for melatonin biosynthesis in rice
    860. Premature leaf senescence modulated by the Arabidopsis PHYTOALEXIN DEFICIENT4 gene is associated with defense against the phloem-feeding green peach …
    861. Premature lung aging and cellular senescence in the pathogenesis of idiopathic pulmonary fibrosis and COPD/emphysema
    862. Premature mitochondrial senescence and related ultrastructural changes during lung carcinogenesis modulation by curcumin and resveratrol
    863. Premature senescence activation in DLD‑1 colorectal cancer cells through adjuvant therapy to induce a miRNA profile modulating cellular death
    864. Premature senescence and cellular phenotype transformation of mesangial cells induced by TGF-B1
    865. Premature senescence and increased TGFβ signaling in the absence of Tgif1
    866. Premature Senescence in Cells From Patients With Autosomal Recessive Hypercholesterolemia (ARH) Evidence for a Role for ARH in Mitosis
    867. Premature senescence in cultured skin fibroblasts from subjects with cystic fibrosis
    868. Premature senescence in human breast cancer and colon cancer cells by tamoxifen-mediated reactive oxygen species generation
    869. Premature senescence in human diploid fibroblasts induced by oxidative stress and by stimulations with the pro-inflammatory cytokines. A review.
    870. Premature senescence in plants along a motorway
    871. Premature senescence in primary muscle cultures of myotonic dystrophy type 2 is not associated with p16 induction
    872. Premature Senescence in Primary Muscle Cultures of Myotonic Dystrophy Type 2 Is Not Associated With p16 Induction (P2. 047)
    873. Premature senescence induced by DNA demethylating agent (Decitabine) as therapeutic option for malignant pleural mesothelioma
    874. Premature Senescence Induced by Ionizing Radiation Requires AKT Activity and Reactive Oxygen Species in Glioma
    875. Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling
    876. Premature senescence is a major response to DNA cross-linking agents in BRCA1-defective cells: implication for tailored treatments of BRCA1 mutation carriers
    877. Premature senescence is a primary fail-safe mechanism of ERBB2-driven tumorigenesis in breast carcinoma cells
    878. Premature senescence of balding dermal papilla cells in vitro is associated with p16INK4a expression
    879. Premature senescence of cardiac fibroblasts and atrial fibrosis in patients with atrial fibrillation
    880. Premature senescence of circulating T cells in HCV-chronically infected patients (105.41)
    881. Premature senescence of cotton (Gossypium hirsutum L.)–Predominantly a potassium disorder caused by an imbalance of source and sink
    882. Premature senescence of cotton: current developments
    883. Premature Senescence of Cotton—The Future of Crop Nutrition Problems?
    884. Premature senescence of endothelial cells upon chronic exposure to TNFα can be prevented by N-acetyl cysteine and plumericin
    885. Premature senescence of endothelial cells: Methusaleh’s dilemma
    886. Premature senescence of highly proliferative endothelial progenitor cells is induced by tumor necrosis factor-α via the p38 mitogen-activated protein kinase pathway
    887. Premature senescence of human endothelial cells induced by inhibition of glutaminase
    888. Premature senescence of mesothelial cells is associated with non-telomeric DNA damage
    889. Premature Senescence of Naïve CD4+ T-Cells in Systemic Lupus Erythematosus
    890. Premature senescence of skin fibroblasts from insulin-dependent diabetic patients with kidney disease
    891. Premature senescence of T cells in long-term survivors of renal transplantation
    892. Premature senescence of T lymphocytes from patients with β-thalassemia major
    893. Premature senescence of T-cell subsets in axial spondyloarthritis
    894. Premature senescence of the immune system in rheumatoid arthritis and multiple sclerosis patients.
    895. Premature senescence of vascular cells is induced by HIV protease inhibitors: implication of prelamin A and reversion by statin
    896. Premature senescence, endothelial turnover and accelerated atherosclerosis in SLE: the relationship between circulating endothelial cells, telomere length and …
    897. Premature T cell senescence in Ovx mice is inhibited by repletion of estrogen and medicarpin: a possible mechanism for alleviating bone loss
    898. Premature T cell senescence in pediatric CKD
    899. Premature vascular senescence in metabolic syndrome: Could it be prevented and reversed by a selenorganic antioxidant and peroxynitrite scavenger ebselen?
    900. Prevention and reversal of premature endothelial cell senescence and vasculopathy in obesity-induced diabetes by ebselen
    901. Prevention of premature senescence requires JNK regulation of Bcl-2 and reactive oxygen species
    902. Probucol inhibits JAK2−STAT pathway activation and protects human glomerular mesangial cells from tert-butyl hydroperoxide induced premature senescence
    903. Profile gene expression of H_ (2) O_ (2)-induced premature senescence of human fibroblasts
    904. Profile of P66SHC expression and histone modifications in replicative cell senescence and oxidative-stress induced premature senescence
    905. Progerin-induced replication stress facilitates premature senescence in Hutchinson-Gilford progeria syndrome
    906. Program of premature senescence is not induced by sodium butyrate in transformants with JNK1, 2 knockout
    907. Progress in molecular mechanism underlying plant premature senescence
    908. Promising markers for the detection of premature senescence tumor cells induced by ionizing radiation: Cathepsin D and eukaryotic translation elongation factor 1
    909. Propagation Of Stress-Induced Premature Senescence In Culture Of Human Endometrial Stem Cells: Paracrine Effect Of Igf-Binding Protein 3
    910. Protective potential of mistletoe (Viscum album coloratum) against oxidative stress and cellular premature senescence
    911. Proteome oxidative carbonylation during oxidative stress-induced premature senescence of WI-38 human fibroblasts
    912. Pseudomonas pyocyanin inhibits wound repair by inducing premature cellular senescence: role for p38 mitogen-activated protein kinase
    913. Psoralen plus UVA (PUVA) induced premature senescence as a model for stress-induced premature senescence
    914. PTEN status switches cell fate between premature senescence and apoptosis in glioma exposed to ionizing radiation
    915. Purple sweet potato color inhibits endothelial premature senescence by blocking the NLRP3 inflammasome
    916. QTL mapping for premature senescence and related physiological traits in Wheat
    917. Quantitative proteomic analysis reveals induction of premature senescence in human umbilical vein endothelial cells exposed to chronic low‐dose rate gamma …
    918. Radiation-induced premature cellular senescence involved in glomerular diseases in rats
    919. Radiation-induced premature senescence is associated with specific cytogenetic changes
    920. RAP2.6L overexpression delays waterlogging induced premature senescence by increasing stomatal closure more than antioxidant enzyme activity
    921. Rapamycin increases radiosensitivity of cancer cells by induction of premature senescence.
    922. Rat notochordal cells undergo premature stress-induced senescence by high glucose
    923. RB maintains quiescence and prevents premature senescence through upregulation of DNMT1 in mesenchymal stromal cells
    924. Real space flight travel is associated with ultrastructural changes, cytoskeletal disruption and premature senescence of HUVEC
    925. Reasons of cotton premature senescence in Xinjiang and related prevention and control techniques.
    926. Receptor for advanced glycation end-products promotes premature senescence of proximal tubular epithelial cells via activation of endoplasmic reticulum stress …
    927. REDD1 protects osteoblast cells from gamma radiation-induced premature senescence
    928. Reducing mammary cancer risk through premature stem cell senescence
    929. Reductions in the number of mid-sized antral follicles are associated with markers of premature ovarian senescence in dairy cows
    930. Regiospecific Synthesis of Ring A Fused Withaferin A Isoxazoline Analogues: Induction of Premature Senescence by W-2b in Proliferating Cancer Cells
    931. Regrowth of Human Dermal Fibroblasts after 8-MOP plus UVA Treatment Implications for Stress-Induced Premature Senescence and Replicative Cellular …
    932. Regulation and role of miRNA and target genes in cell cycle during oxidative stress-induced premature senescence in mesenchymal stem cells
    933. Regulation of arginine methylation in endothelial cells: role in premature senescence and apoptosis
    934. Regulation of Respiration and the Oxygen Diffusion Barrier in Soybean Protect Symbiotic Nitrogen Fixation from Chilling-Induced Inhibition and Shoots from Premature Senescence
    935. Regulation of Subsoiling on Premature Senescence of Corn [J]
    936. Regulation of the Promyelocytic Leukemia Protein and Its Role in Premature Senescence
    937. Release and suppression of caspases by gamma-tocotrienol prevent apoptosis and delay aging in stress-induced premature senescence of skin fibroblasts
    938. Repeated exposure of human skin fibroblasts to UVB at subcytotoxic level triggers premature senescence through the TGF-β1 signaling pathway
    939. Repeated exposure of mouse dermal fibroblasts at a sub-cytotoxic dose of UVB leads to premature senescence: a robust model of cellular photoaging
    940. Replicative senescence and oxidant‐induced premature senescence: beyond the control of cell cycle checkpoints
    941. Repression of the SUMO‐specific protease Senp1 induces p53‐dependent premature sen