Klotho
July 30, 2019HSP90
January 6, 2020- Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis
- Human SIR2 deacetylates p53 and antagonizes PML/p53‐induced cellular senescence
- Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
- Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
- PML regulates p53 acetylation and premature senescence induced by oncogenic Ras
- Regulation of cellular senescence by p53
- Reversal of human cellular senescence: roles of the p53 and p16 pathways
- Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor
- A role for both RB and p53 in the regulation of human cellular senescence
- Senescence and aging: the critical roles of p53
- A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy
- Paradoxical suppression of cellular senescence by p53
- Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence
- Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling
- Oncogenic ras and p53 cooperate to induce cellular senescence
- Escape from senescence in human diploid fibroblasts induced directly by mutant p53.
- Wild-type p53 triggers a rapid senescence program in human tumor cells lacking functional p53
- Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21CIP1, but not p16INK4a
- Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence
- JunD protects cells from p53-dependent senescence and apoptosis
- Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer
- p53, ROS and senescence in the control of aging
- Adriamycin-induced senescence in breast tumor cells involves functional p53 and telomere dysfunction
- Pathways connecting telomeres and p53 in senescence, apoptosis, and cancer
- Reversal of senescence in mouse fibroblasts through lentiviral suppression of p53
- p53-independent upregulation of miR-34a during oncogene-induced senescence represses MYC
- SIRT1 and p53, effect on cancer, senescence and beyond
- Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence
- Weak p53 permits senescence during cell cycle arrest
- The choice between p53-induced senescence and quiescence is determined in part by the mTOR pathway
- Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence
- Significant role for p16INK4a in p53-independent telomere-directed senescence
- Tumour suppression by p53: the importance of apoptosis and cellular senescence
- Evidence that transcriptional activation by p53 plays a direct role in the induction of cellular senescence.
- Telomere dysfunction suppresses spontaneous tumorigenesis in vivo by initiating p53‐dependent cellular senescence
- p53 isoforms Δ133p53 and p53β are endogenous regulators of replicative cellular senescence
- DNA damage signaling and p53-dependent senescence after prolonged β-interferon stimulation
- Suppression of p53-dependent senescence by the JNK signal transduction pathway
- A two-stage, p16INK4A-and p53-dependent keratinocyte senescence mechanism that limits replicative potential independent of telomere status
- Loss of miRNA biogenesis induces p19Arf-p53 signaling and senescence in primary cells
- Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform
- p53-independent regulation of p21Waf1/Cip1 expression and senescence by Chk2
- ARF functions as a melanoma tumor suppressor by inducing p53-independent senescence
- Role of p53 and p21waf1/cip1 in senescence-like terminal proliferation arrest induced in human tumor cells by chemotherapeutic drugs
- Hsp27 modulates p53 signaling and suppresses cellular senescence
- Posttranslational modifications of p53 in replicative senescence overlapping but distinct from those induced by DNA damage
- Escape from therapy-induced accelerated cellular senescence in p53-null lung cancer cells and in human lung cancers
- A senescence rescue screen identifies BCL6 as an inhibitor of anti-proliferative p19ARF–p53 signaling
- p53 Mediates the accelerated onset of senescence of endothelial progenitor cells in diabetes
- p53-mediated senescence impairs the apoptotic response to chemotherapy and clinical outcome in breast cancer
- PML interaction with p53 and its role in apoptosis and replicative senescence
- SOCS1 links cytokine signaling to p53 and senescence
- The p400 E1A-associated protein is a novel component of the p53→ p21 senescence pathway
- Uterine-specific p53 deficiency confers premature uterine senescence and promotes preterm birth in mice
- p53: guardian of cellular senescence
- From telomere loss to p53 induction and activation of a DNA-damage pathway at senescence: the telomere loss/DNA damage model of cell aging
- Ser46 phosphorylation regulates p53-dependent apoptosis and replicative senescence
- Senescence regulation by the p53 protein family
- The M‐type receptor PLA2R regulates senescence through the p53 pathway
- Nutlin-3a activates p53 to both down-regulate inhibitor of growth 2 and up-regulate mir-34a, mir-34b, and mir-34c expression, and induce senescence
- Manganese superoxide dismutase induces p53-dependent senescence in colorectal cancer cells
- Apoptosis or senescence-like growth arrest: influence of cell-cycle position, p53, p21 and bax in H2O2 response of normal human fibroblasts
- p21Waf1/Cip1/Sdi1 induces permanent growth arrest with markers of replicative senescence in human tumor cells lacking functional p53
- … damaging agents and p53 do not cause senescence in quiescent cells, while consecutive re-activation of mTOR is associated with conversion to senescence
- p53-Dependent accelerated senescence induced by ionizing radiation in breast tumour cells
- ING2 regulates the onset of replicative senescence by induction of p300-dependent p53 acetylation
- Cdk4 disruption renders primary mouse cells resistant to oncogenic transformation, leading to Arf/p53-independent senescence
- http://genesdev.cshlp.org/content/16/22/2923.short
- CPEB regulation of human cellular senescence, energy metabolism, and p53 mRNA translation
- Disturbed flow promotes endothelial senescence via a p53-dependent pathway
- p53-dependent translational control of senescence and transformation via 4E-BPs
- Deregulation of oncogene‐induced senescence and p53 translational control in X‐linked dyskeratosis congenita
- Cellular senescence: ex vivo p53-dependent asymmetric cell kinetics
- Induced p53 expression in lung cancer cell line promotes cell senescence and differentially modifies the cytotoxicity of anti-cancer drugs
- p53 is preferentially recruited to the promoters of growth arrest genes p21 and GADD45 during replicative senescence of normal human fibroblasts
- Mutant p53 rescues human diploid cells from senescence without inhibiting the induction of SDI1/WAF1
- H2O2 accelerates cellular senescence by accumulation of acetylated p53 via decrease in the function of SIRT1 by NAD+ depletion
- Expression of SUMO-2/3 induced senescence through p53-and pRB-mediated pathways
- Cooperative interactions between RB and p53 regulate cell proliferation, cell senescence, and apoptosis in human vascular smooth muscle cells from atherosclerotic …
- DEC1, a basic helix-loop-helix transcription factor and a novel target gene of the p53 family, mediates p53-dependent premature senescence
- Interferon-γ induces cellular senescence through p53-dependent DNA damage signaling in human endothelial cells
- 5‐Lipoxygenase regulates senescence‐like growth arrest by promoting ROS‐dependent p53 activation
- Induction of p53-dependent senescence by the MDM2 antagonist nutlin-3a in mouse cells of fibroblast origin
- Definition of pRB-and p53-dependent and-independent steps in HIRA/ASF1a-mediated formation of senescence-associated heterochromatin foci
- Polybromo-associated BRG1-associated factor components BRD7 and BAF180 are critical regulators of p53 required for induction of replicative senescence
- Transient activation of p53 in G2 phase is sufficient to induce senescence
- A dominant role for p53-dependent cellular senescence in radiosensitization of human prostate cancer cells
- Early growth response 1 protein, an upstream gatekeeper of the p53 tumor suppressor, controls replicative senescence
- Sodium Butyrate Induces NIH3T3 cells to senescence-like state and enhances promoter activity of p21WAF/CIP1in p53-Independent manner
- Chronic treatment with resveratrol induces redox stress-and ataxia telangiectasia-mutated (ATM)-dependent senescence in p53-positive cancer cells
- Human fibroblasts require the Rb family of tumor suppressors, but not p53, for PML-induced senescence
- Klotho RNAi induces premature senescence of human cells via a p53/p21 dependent pathway
- Caveolin-1 regulates the antagonistic pleiotropic properties of cellular senescence through a novel Mdm2/p53-mediated pathway
- AKT induces senescence in human cells via mTORC1 and p53 in the absence of DNA damage: implications for targeting mTOR during malignancy
- p53-Independent regulation of p21Waf1/Cip1 expression and senescence by PRMT6
- Activation of p53 by nutlin-3a induces apoptosis and cellular senescence in human glioblastoma multiforme
- p53 and its homologues, p63 and p73, induce a replicative senescence through inactivation of NF-Y transcription factor
- Dynamic regulation of p53 subnuclear localization and senescence by MORC3
- Splicing-factor oncoprotein SRSF1 stabilizes p53 via RPL5 and induces cellular senescence
- The relative contributions of the p53 and pRb pathways in oncogene-induced melanocyte senescence
- MOZ increases p53 acetylation and premature senescence through its complex formation with PML
- p53-dependent senescence delays Eμ-myc-induced B-cell lymphomagenesis
- Shifting senescence into quiescence by turning up p53
- Senescence and dysfunction of proximal tubular cells are associated with activated p53 expression by indoxyl sulfate
- Positive feedback between p53 and TRF2 during telomere-damage signalling and cellular senescence
- The atypical E2F family member E2F7 couples the p53 and RB pathways during cellular senescence
- Repression of the human papillomavirus E6 gene initiates p53-dependent, telomerase-independent senescence and apoptosis in HeLa cervical carcinoma cells
- … papillomavirus oncoprotein E7 targets the promyelocytic leukemia protein and circumvents cellular senescence via the Rb and p53 tumor suppressor pathways
- p53 mediates senescence-like arrest induced by chronic replicational stress
- Oxidative stress activates a specific p53 transcriptional response that regulates cellular senescence and aging
- Characterization of the p53 response to oncogene-induced senescence
- Downregulation of splicing factor SRSF3 induces p53β, an alternatively spliced isoform of p53 that promotes cellular senescence
- Bach1 inhibits oxidative stress–induced cellular senescence by impeding p53 function on chromatin
- Ionizing radiation‐induced long‐term expression of senescence markers in mice is independent of p53 and immune status
- Control of p53 and NF-κB signaling by WIP1 and MIF: role in cellular senescence and organismal aging
- WNT16B is a new marker of cellular senescence that regulates p53 activity and the phosphoinositide 3-kinase/AKT pathway
- UVB-induced senescence in human keratinocytes requires a functional insulin-like growth factor-1 receptor and p53
- SOCS1, a novel interaction partner of p53 controlling oncogene-induced senescence
- Senescence-associated alterations of cytoskeleton: extraordinary production of vimentin that anchors cytoplasmic p53 in senescent human fibroblasts
- Pharmacologic p53 activation blocks cell cycle progression but fails to induce senescence in epithelial cancer cells
- Mdm2–p53 signaling regulates epidermal stem cell senescence and premature aging phenotypes in mouse skin
- CENP-A reduction induces a p53-dependent cellular senescence response to protect cells from executing defective mitoses
- Insulin‐like growth factor‐1 regulates the SIRT 1‐p53 pathway in cellular senescence
- Limited role of murine ATM in oncogene-induced senescence and p53-dependent tumor suppression
- YPEL3, a p53-regulated gene that induces cellular senescence
- TGF-β signaling engages an ATM-CHK2-p53–independent RAS-induced senescence and prevents malignant transformation in human mammary epithelial cells
- p53 isoforms regulate aging-and tumor-associated replicative senescence in T lymphocytes
- The ARF-p53 senescence pathway in mouse and human cells
- Nek6 overexpression antagonizes p53-induced senescence in human cancer cells
- An accelerated senescence response to radiation in wild-type p53 glioblastoma multiforme cells
- Molecular chaperones regulate p53 and suppress senescence programs
- Contribution of p16INK4a and p21CIP1 pathways to induction of premature senescence of human endothelial cells: permissive role of p53
- Indoxyl sulfate promotes vascular smooth muscle cell senescence with upregulation of p53, p21, and prelamin A through oxidative stress
- β-catenin expression results in p53-independent DNA damage and oncogene-induced senescence in prelymphomagenic thymocytes in vivo
- Hyperoxia-induced premature senescence requires p53 and pRb, but not mitochondrial matrix ROS
- p53_inducing_drug_dosage_may_determine_quiescence_or_senescence/links/54ccad9b0cf298d6565aaada.pdf”>The p53 inducing drug dosage may determine quiescence or senescence
- Reduction of total E2F/DP activity induces senescence-like cell cycle arrest in cancer cells lacking functional pRB and p53
- Negative regulation of transcription factor FoxM1 by p53 enhances oxaliplatin-induced senescence in hepatocellular carcinoma
- Knockin mice expressing a chimeric p53 protein reveal mechanistic differences in how p53 triggers apoptosis and senescence
- Indoxyl sulfate induces endothelial cell senescence by increasing reactive oxygen species production and p53 activity
- Repression of the SUMO‐specific protease Senp1 induces p53‐dependent premature senescence in normal human fibroblasts
- Cooperation between p53 and p130 (Rb2) in induction of cellular senescence
- Resistance to UV‐induced apoptosis in human keratinocytes during accelerated senescence is associated with functional inactivation of p53
- Vitamin C inhibits p53-induced replicative senescence through suppression of ROS production and p38 MAPK activity
- Inactivation of p53 function in cultured human mammary epithelial cells turns the telomere-length dependent senescence barrier from agonescence into crisis
- The ATM/p53/p21 pathway influences cell fate decision between apoptosis and senescence in reoxygenated hematopoietic progenitor cells
- hAda3 regulates p14ARF-induced p53 acetylation and senescence
- Perturbation of ribosome biogenesis drives cells into senescence through 5S RNP-mediated p53 activation
- p53 and p16INK4A independent induction of senescence by chromatin-dependent alteration of S-phase progression
- Aurora A overexpression induces cellular senescence in mammary gland hyperplastic tumors developed in p53-deficient mice
- Activation of p53 by Nutlin-3a, an antagonist of MDM2, induces apoptosis and cellular senescence in adult T-cell leukemia cells
- Activation of PPARγ/p53 signaling is required for curcumin to induce hepatic stellate cell senescence
- MageA2 restrains cellular senescence by targeting the function of PMLIV/p53 axis at the PML-NBs
- Expression profiles of p53 and p66shc during oxidative stress-induced senescence in fetal bovine fibroblasts
- Oxidative stress-induced inhibition of Sirt1 by caveolin-1 promotes p53-dependent premature senescence and stimulates the secretion of interleukin 6 (IL-6)
- Telomeres, p53 and cellular senescence
- Ha-RasG12V induces senescence in primary and immortalized human esophageal keratinocytes with p53 dysfunction
- Low concentration of metformin induces a p53-dependent senescence in hepatoma cells via activation of the AMPK pathway
- Bcl-2 can promote p53-dependent senescence versus apoptosis without affecting the G1/S transition
- Inhibitor of apoptosis-stimulating protein of p53 (iASPP) prevents senescence and is required for epithelial stratification
- Redox control and interplay between p53 isoforms: roles in the regulation of basal p53 levels, cell fate, and senescence
- Bcl-xL and E1B-19K proteins inhibit p53-induced irreversible growth arrest and senescence by preventing reactive oxygen species-dependent p38 activation
- Regulation of p53 and Rb links the alternative NF-κB pathway to EZH2 expression and cell senescence
- Expression of an IFN-inducible cellular senescence gene, IFI16, is up-regulated by p53
- Tumor suppression by p53 without apoptosis and senescence: conundrum or rapalog-like gerosuppression?
- Altered senescence, apoptosis, and DNA damage response in a mutant p53 model of accelerated aging
- Sunitinib induces cellular senescence via p53/D ec1 activation in renal cell carcinoma cells
- Irradiation of adult human dental pulp stem cells provokes activation of p53, cell cycle arrest, and senescence but not apoptosis
- SCFFbxo22-KDM4A targets methylated p53 for degradation and regulates senescence
- Influence of p53 and caspase 3 activity on cell death and senescence in response to methotrexate in the breast tumor cell
- Rb2/p130 is the dominating pocket protein in the p53–p21 DNA damage response pathway leading to senescence
- CLCA2 as a p53-inducible senescence mediator
- Culturing on Wharton’s jelly extract delays mesenchymal stem cell senescence through p53 and p16INK4a/pRb pathways
- Reduced mitochondrial membrane potential and altered responsiveness of a mitochondrial membrane megachannel in p53-induced senescence
- 20 (S)-ginsenoside Rg3 promotes senescence and apoptosis in gallbladder cancer cells via the p53 pathway
- Possible involvement of p21 but not of p16 or p53 in keratinocyte senescence
- Expression of hepaCAM is downregulated in cancers and induces senescence-like growth arrest via a p53/p21-dependent pathway in human breast cancer cells
- p53 is required for metformin-induced growth inhibition, senescence and apoptosis in breast cancer cells
- Insights into 4E-BP1 and p53 mediated regulation of accelerated cell senescence
- Ninjurin1, a target of p53, regulates p53 expression and p53-dependent cell survival, senescence, and radiation-induced mortality
- Interstitial chromatin alteration causes persistent p53 activation involved in the radiation-induced senescence-like growth arrest
- Role of in Replicative Senescence and DNA Damage-Induced Premature Senescence in p53-Deficient Human Cells
- NORE1A is a Ras senescence effector that controls the apoptotic/senescent balance of p53 via HIPK2
- Autophagic degradation of the inhibitory p53 isoform Δ133p53α as a regulatory mechanism for p53-mediated senescence
- Induction of Cellular Senescence by Secretory Phospholipase A2 in Human Dermal Fibroblasts through an ROS-Mediated p53 Pathway
- p63 and p73 coordinate p53 function to determine the balance between survival, cell death, and senescence in adult neural precursor cells
- IGFBP-rP1 induces p21 expression through a p53-independent pathway, leading to cellular senescence of MCF-7 breast cancer cells
- Absence of p53-dependent apoptosis leads to UV radiation hypersensitivity, enhanced immunosuppression and cellular senescence
- Nutlin-3, the small-molecule inhibitor of MDM2, promotes senescence and radiosensitises laryngeal carcinoma cells harbouring wild-type p53
- Activation of p53 with Nutlin-3a radiosensitizes lung cancer cells via enhancing radiation-induced premature senescence
- … peroxide induced premature senescence: senescence-associated β-galactosidase and DNA synthesis index in human diploid fibroblasts with down-regulated p53 or …
- Glucocorticoids induce senescence in primary human tenocytes by inhibition of sirtuin 1 and activation of the p53/p21 pathway: in vivo and in vitro evidence
- MDM2 inhibitor nutlin-3a induces apoptosis and senescence in cutaneous T-cell lymphoma: role of p53
- Replicative senescence in sheep fibroblasts is a p53 dependent process
- IGF-I enhances cellular senescence via the reactive oxygen species–p53 pathway
- The p53-p21Cip1/WAF1 pathway is necessary for cellular senescence induced by the inhibition of protein kinase CKII in human colon cancer cells
- Metformin and resveratrol inhibited high glucose-induced metabolic memory of endothelial senescence through SIRT1/p300/p53/p21 pathway
- p53-dependent induction of prostate cancer cell senescence by the PIM1 protein kinase
- Wnt/β-catenin signaling mediates the senescence of bone marrow-mesenchymal stem cells from systemic lupus erythematosus patients through the p53/p21 pathway
- Reactive oxygen species and p21Waf1/Cip1 are both essential for p53-mediated senescence of head and neck cancer cells
- Loss of p53-mediated cell-cycle arrest, senescence and apoptosis promotes genomic instability and premature aging
- p53-Rb signaling pathway is involved in tubular cell senescence in renal ischemia/reperfusion injury
- Down‐regulation of Aurora B kinase induces cellular senescence in human fibroblasts and endothelial cells through a p53‐dependent pathway
- Interferon-β induces cellular senescence in cutaneous human papilloma virus-transformed human keratinocytes by affecting p53 transactivating activity
- Physiological ageing: role of p53 and PARP-1 tumor suppressors in the regulation of terminal senescence
- POZ/BTB and AT-hook-containing zinc finger protein 1 (PATZ1) inhibits endothelial cell senescence through a p53 dependent pathway
- Dehydroepiandrosterone inhibits the progression phase of mammary carcinogenesis by inducing cellular senescence via a p16-dependent but p53 …
- PML IV/ARF interaction enhances p53 SUMO-1 conjugation, activation, and senescence
- p53-induced autophagy and senescence
- Cell contact accelerates replicative senescence of human mesenchymal stem cells independent of telomere shortening and p53 activation: roles of Ras and oxidative …
- ARF triggers senescence in Brca2-deficient cells by altering the spectrum of p53 transcriptional targets
- Methylseleninic acid superactivates p53-senescence cancer progression barrier in prostate lesions of pten-knockout mouse
- The BRG1 ATPase of chromatin remodeling complexes is involved in modulation of mesenchymal stem cell senescence through RB–p53 pathways
- p53 isoform Δ113p53/Δ133p53 promotes DNA double-strand break repair to protect cell from death and senescence in response to DNA damage
- Dexamethasone reduces sensitivity to cisplatin by blunting p53-dependent cellular senescence in non-small cell lung cancer
- Carcinogen-specific mutational and epigenetic alterations in INK4A, INK4B and p53 tumour-suppressor genes drive induced senescence bypass in normal …
- BCL6-mediated attenuation of DNA damage sensing triggers growth arrest and senescence through a p53-dependent pathway in a cell context-dependent manner
- 2, 3, 5, 4′-tetrahydroxystilbene-2-O-β-d-glucoside ameliorates vascular senescence and improves blood flow involving a mechanism of p53 deacetylation
- Busulfan selectively induces cellular senescence but not apoptosis in WI38 fibroblasts via a p53-independent but extracellular signal-regulated kinase-p38 mitogen …
- Loss of the osteogenic differentiation potential during senescence is limited to bone progenitor cells and is dependent on p53
- Novel ARF/p53-independent senescence pathways in cancer repression
- FL118 induces p53-dependent senescence in colorectal cancer cells by promoting degradation of MdmX
- p53 deacetylation by SIRT1 decreases during protein kinase CKII downregulation-mediated cellular senescence
- Induction of senescence-like phenotype and loss of paclitaxel sensitivity after wild-type p53 gene transfection of p53-null human non-small cell lung cancer H358 cells …
- Nucleophosmin 1, upregulated in adenomas and cancers of the colon, inhibits p53‐mediated cellular senescence
- Phosphatidylcholine‐specific phospholipase C, p53 and ROS in the association of apoptosis and senescence in vascular endothelial cells
- Suppression of the p53-dependent replicative senescence response by lysophosphatidic acid signaling
- Chemokine receptor CXCR 2 is transactivated by p53 and induces p38‐mediated cellular senescence in response to DNA damage
- Another”” Janus paradox”” of p53: induction of cell senescence versus quiescence
- A new p53 target gene, RKIP, is essential for DNA damage-induced cellular senescence and suppression of ERK activation
- … a senescence-like change via the down-regulation of SIRT1 and up-regulation of p53 protein in human esophageal squamous cancer cells with a wild-type p53 gene …
- A single-codon mutation converts HPV16 E6 oncoprotein into a potential tumor suppressor, which induces p53-dependent senescence of HPV-positive HeLa …
- Multiple facets of p53 in senescence induction and maintenance
- Regulation of p53 during senescence in normal human keratinocytes
- mTOR favors senescence over quiescence in p53-arrested cells
- Wild-type and Hupki (Human p53 Knock-in) Murine Embryonic Fibroblasts p53/ARF PATHWAY DISRUPTION IN SPONTANEOUS ESCAPE FROM SENESCENCE
- Cellular senescence induced by p53‐ras cooperation is independent of p21waf1 in murine embryo fibroblasts
- Role for p53 in selenium-induced senescence
- IGF-I induces senescence of hepatic stellate cells and limits fibrosis in a p53-dependent manner
- The p53/p21WAF/CIP Pathway Mediates Oxidative Stress and Senescence in Dyskeratosis Congenita Cells with Telomerase Insufficiency
- Arginase‐II Induces Vascular Smooth Muscle Cell Senescence and Apoptosis Through p66Shc and p53 Independently of Its l‐Arginine Ureahydrolase Activity …
- Be quiet and you’ll keep young: does mTOR underlie p53 action in protecting against senescence by favoring quiescence?
- TRIB3 promotes APL progression through stabilization of the oncoprotein PML-RARα and inhibition of p53-mediated senescence
- ATP‐citrate lyase regulates cellular senescence via an AMPK‐and p53‐dependent pathway
- Loss of BRG1 induces CRC cell senescence by regulating p53/p21 pathway
- … p53 codon 72 Pro/Pro genotype identifies poor-prognosis neuroblastoma patients: correlation with reduced apoptosis and enhanced senescence by the p53 …
- Inhibition enhancer of zeste homologue 2 promotes senescence and apoptosis induced by doxorubicin in p53 mutant gastric cancer cells
- CHIP-dependent p53 regulation occurs specifically during cellular senescence
- ATM kinase enables the functional axis of YAP, PML and p53 to ameliorate loss of Werner protein-mediated oncogenic senescence
- Contribution of estrogen receptor α to oncogenic K-Ras-mediated NIH3T3 cell transformation and its implication for escape from senescence by modulating the p53 …
- Molecular insights into SIRT1 protection against UVB-induced skin fibroblast senescence by suppression of oxidative stress and p53 acetylation
- MAD2 depletion triggers premature cellular senescence in human primary fibroblasts by activating a p53 pathway preventing aneuploid cells propagation
- 58-kDa microspherule protein (MSP58) is novel Brahma-related gene 1 (BRG1)-associated protein that modulates p53/p21 senescence pathway
- Retinoblastoma‐independent regulation of cell proliferation and senescence by the p53–p21 axis in lamin A/C‐depleted cells
- The regulation of cellular functions by the p53 protein: cellular senescence
- p53/p21 Pathway involved in mediating cellular senescence of bone marrow-derived mesenchymal stem cells from systemic lupus erythematosus patients
- Elevated p53 expression in benign meningiomas protects against recurrence and may be indicative of senescence
- p53: The pivot between cell cycle arrest and senescence
- RRM2B suppresses activation of the oxidative stress pathway and is up-regulated by p53 during senescence
- Partial proteasome inhibition in human fibroblasts triggers accelerated M1 senescence or M2 crisis depending on p53 and Rb status
- … suppression of HMGB1 induces cell cycle arrest and senescence in association with p21 (Waf1/Cip1) up-regulation via a p53-independent, Sp1-dependent …
- SIRT1 alleviates senescence of degenerative human intervertebral disc cartilage endo-plate cells via the p53/p21 pathway
- CARF: an emerging regulator of p53 tumor suppressor and senescence pathway
- VentX trans-activates p53 and p16ink4a to regulate cellular senescence
- Caveolin-1/PTRF upregulation constitutes a mechanism for mediating p53-induced cellular senescence: implications for evidence-based therapy of delayed wound …
- Cooperation between p21 and Akt is required for p53‐dependent cellular senescence
- Aberrant autolysosomal regulation is linked to the induction of embryonic senescence: differential roles of Beclin 1 and p53 in vertebrate Spns1 deficiency
- Numb is required to prevent p53-dependent senescence following skeletal muscle injury
- RNA-binding protein FXR1 regulates p21 and TERC RNA to bypass p53-mediated cellular senescence in OSCC
- Overexpression of the pituitary tumor transforming gene induces p53-dependent senescence through activating DNA damage response pathway in normal human …
- Increased expression of SIRT2 is a novel marker of cellular senescence and is dependent on wild type p53 status
- Arsenite induces premature senescence via p53/p21 pathway as a result of DNA damage in human malignant glioblastoma cells
- Serpine 1 induces alveolar type II cell senescence through activating p53‐p21‐Rb pathway in fibrotic lung disease
- Senescence of bone marrow mesenchymal stromal cells is accompanied by activation of p53/p21 pathway in myelodysplastic syndromes
- Implication of p53-dependent cellular senescence related gene, TARSH in tumor suppression
- … inhibitors combined with retinoic acid can enhance differentiation of neuroblastoma cells and trigger ERK-and AKT-dependent, p53-independent senescence
- The effects of fucodian on senescence are controlled by the p16INK4a-pRb and p14Arf-p53 pathways in hepatocellular carcinoma and hepatic cell lines
- BS69 is involved in cellular senescence through the p53–p21Cip1 pathway
- Cellular and organismal ageing: Role of the p53 tumor suppressor protein in the induction of transient and terminal senescence
- Simvastatin rises reactive oxygen species levels and induces senescence in human melanoma cells by activation of p53/p21 pathway
- The p53-reactivating small molecule RITA induces senescence in head and neck cancer cells
- An indirect role for ASPP1 in limiting p53‐dependent p21 expression and cellular senescence
- Depletion of securin induces senescence after irradiation and enhances radiosensitivity in human cancer cells regardless of functional p53 expression
- … S6 kinase (RSK) inhibitor BI-D1870 prevents gamma irradiation-induced apoptosis and mediates senescence via RSK-and p53-independent accumulation of …
- Inhibitory effect of Lycium barbarum polysaccharides on cell apoptosis and senescence is potentially mediated by the p53 signaling pathway
- … anti-tumor mechanisms include Hsp60 post-translational modifications leading to the Hsp60/p53 complex dissociation and instauration of replicative senescence
- … secreted PDZ domain-containing protein 2 (sPDZD2) induces senescence or quiescence of prostate, breast and liver cancer cells via transcriptional activation of p53
- Silencing of protein kinase D2 induces glioma cell senescence via p53-dependent and-independent pathways
- Identification of p53-dependent genes potentially involved in UVB-mediated premature senescence of human skin fibroblasts using siRNA technology
- Suppression of the DHX9 helicase induces premature senescence in human diploid fibroblasts in a p53-dependent manner
- … -glycoside-A fraction of Gonolobus condurango induces DNA damage associated senescence and apoptosis via ROS-dependent p53 signalling pathway in HeLa …
- Engaging the p53 metabolic brake drives senescence
- NQO1 stabilizes p53 in response to oncogene-induced senescence
- Shikonin induces apoptosis, necrosis, and premature senescence of human A549 lung cancer cells through upregulation of p53 expression
- Preventive Effects of Epigallocatechin-3-O-Gallate against Replicative Senescence Associated with p53 Acetylation in Human Dermal Fibroblasts
- mTOR inactivation by ROS-JNK-p53 pathway plays an essential role in psedolaric acid B induced autophagy-dependent senescence in murine fibrosarcoma L929 …
- The matricellular protein CCN1 suppresses lung cancer cell growth by inducing senescence via the p53/p21 pathway
- Integrated stochastic model of DNA damage repair by non-homologous end joining and p53/p21-mediated early senescence signalling
- Diosmin-induced senescence, apoptosis and autophagy in breast cancer cells of different p53 status and ERK activity
- Cell-penetrating superoxide dismutase attenuates oxidative stress-induced senescence by regulating the p53-p21Cip1 pathway and restores osteoblastic …
- HJURP regulates cellular senescence in human fibroblasts and endothelial cells via a p53-dependent pathway
- pRB, p53, p16 INK4a, senescence and malignant transformation
- Centrosome aberrations associated with cellular senescence and p53 localization at supernumerary centrosomes
- TSH overcomes BrafV600E-induced senescence to promote tumor progression via downregulation of p53 expression in papillary thyroid cancer
- Truncated HBx‐dependent silencing of GAS2 promotes hepatocarcinogenesis through deregulation of cell cycle, senescence and p53‐mediated apoptosis
- Phospholipase D2 downregulation induces cellular senescence through a reactive oxygen species–p53–p21Cip1/WAF1 pathway
- miR-29c-3p promotes senescence of human mesenchymal stem cells by targeting CNOT6 through p53–p21 and p16–pRB pathways
- Mutant lamin A links prophase to a p53 independent senescence program
- CUL4B impedes stress-induced cellular senescence by dampening a p53-reactive oxygen species positive feedback loop
- CDK2 transcriptional repression is an essential effector in p53-dependent cellular senescence—implications for therapeutic intervention
- Soluble egg antigens of Schistosoma japonicum induce senescence in activated hepatic stellate cells by activation of the STAT3/p53/p21 pathway
- HBP1-mediated regulation of p21 protein through the Mdm2/p53 and TCF4/EZH2 pathways and its impact on cell senescence and tumorigenesis
- Δ133p53 represses p53-inducible senescence genes and enhances the generation of human induced pluripotent stem cells
- Estrogens decrease γ-ray–induced senescence and maintain cell cycle progression in breast cancer cells independently of p53
- Knockdown of MBP-1 in human foreskin fibroblasts induces p53-p21 dependent senescence
- Downregulation of Polo-like kinase 1 induces cellular senescence in human primary cells through a p53-dependent pathway
- Secreted protein acidic and rich in cysteine-induced cellular senescence in colorectal cancers in response to irinotecan is mediated by p53
- Activation of adenosine receptor A2A increases HSC proliferation and inhibits death and senescence by down-regulation of p53 and Rb
- p53 and senescence: a little goes a long way
- Wild-type p53-induced phosphatase 1 (Wip1) forestalls cellular premature senescence at physiological oxygen levels by regulating DNA damage response signaling …
- Foxp3 is a key downstream regulator of p53-mediated cellular senescence
- TWEAK increases SIRT1 expression and promotes p53 deacetylation affecting human hepatic stellate cell senescence
- Radiosensitization of prostate cancer by priming the wild-type p53-dependent cellular senescence pathway
- SOCS1 regulates senescence and ferroptosis by modulating the expression of p53 target genes
- p53 suppresses stress-induced cellular senescence via regulation of autophagy under the deprivation of serum
- The homeobox transcription factor Prox1 inhibits proliferation of hepatocellular carcinoma cells by inducing p53-dependent senescence-like phenotype
- ZEB1-induced tumourigenesis requires senescence inhibition via activation of DKK1/mutant p53/Mdm2/CtBP and repression of macroH2A1
- Activation of p53 contributes to pseudolaric acid B-induced senescence in human lung cancer cells in vitro
- CARF Regulates p19ARF‐p53‐p21WAF1 Senescence Pathway by Multiple Checkpoints
- Mithramycin depletes specificity protein 1 and activates p53 to mediate senescence and apoptosis of malignant pleural mesothelioma cells
- Egg antigen p40 of Schistosoma japonicum promotes senescence in activated hepatic stellate cells by activation of the STAT3/p53/p21 pathway
- Knockdown of CDK2AP1 in primary human fibroblasts induces p53 dependent senescence
- Cr (VI) induces premature senescence through ROS-mediated p53 pathway in L-02 hepatocytes
- COH-203, a novel microtubule inhibitor, exhibits potent anti-tumor activity via p53-dependent senescence in hepatocellular carcinoma
- Jekyll and Hyde, the p53 protein, pleiotropics antagonisms and the thrifty aged hypothesis of senescence
- Senescence evasion in melanoma progression: uncoupling of DNA‐damage signaling from p53 activation and p21 expression
- Cellular senescence regulated by SWI/SNF complex subunits through p53/p21 and p16/pRB pathway
- Resveratrol sequentially induces replication and oxidative stresses to drive p53-CXCR2 mediated cellular senescence in cancer cells
- mTOR kinase leads to PTEN-loss-induced cellular senescence by phosphorylating p53
- Regulation of the p19Arf/p53 pathway by histone acetylation underlies neural stem cell behavior in senescence‐prone SAMP8 mice
- p53 and ATF-2 partly mediate the overexpression of COX-2 in H2O2-induced premature senescence of human fibroblasts
- Cyclopentenyl cytosine induces senescence in breast cancer cells through the nucleolar stress response and activation of p53
- Inhibition of p53 prevents diabetic cardiomyopathy by preventing early-stage apoptosis and cell senescence, reduced glycolysis, and impaired angiogenesis
- Agmatine ameliorates high glucose-induced neuronal cell senescence by regulating the p21 and p53 signaling
- Bisphenol A induces DSB-ATM-p53 signaling leading to cell cycle arrest, senescence, autophagy, stress response, and estrogen release in human fetal lung …
- A novel cell-penetrating peptide derived from WT1 enhances p53 activity, induces cell senescence and displays antimelanoma activity in xeno-and syngeneic …
- An RNA interference screen for identifying downstream effectors of the p53 and pRB tumour suppressor pathways involved in senescence
- Identification of a DNA Damage–Induced Alternative Splicing Pathway That Regulates p53 and Cellular Senescence Markers
- Mitotic centromere-associated kinase (MCAK/Kif2C) regulates cellular senescence in human primary cells through a p53-dependent pathway
- Depletion of CSN5 inhibits Ras-mediated tumorigenesis by inducing premature senescence in p53-null cells
- A gain-of-function senescence bypass screen identifies the homeobox transcription factor DLX2 as a regulator of ATM–p53 signaling
- The introduction of dominant-negative p53 mutants suppresses temperature shift-induced senescence in immortal human fibroblasts expressing a thermolabile SV40 …
- Loss of MECP2 leads to activation of p53 and neuronal senescence
- Cholesterol retards senescence in bone marrow mesenchymal stem cells by modulating autophagy and ROS/p53/p21Cip1/Waf1 pathway
- Identification and characterization of a potent activator of p53-independent cellular senescence via a small-molecule screen for modifiers of the integrated stress …
- … tumor cells and glioblastoma cell lines to N, N-bis-(8-hydroxyquinoline-5-yl methyl)-benzyl substituted amines: cell death versus p53-independent senescence
- NORE1A is a double barreled Ras senescence effector that activates p53 and Rb
- p53-dependent downregulation of hTERT protein expression and telomerase activity induces senescence in lung cancer cells as a result of pterostilbene …
- … mTOR pathway inhibition and autophagy induction attenuates adriamycin-induced vascular smooth muscle cell senescence through decreased expressions of p53 …
- Cancer-associated S100P protein binds and inactivates p53, permits therapy-induced senescence and supports chemoresistance
- UBTD1 induces cellular senescence through an UBTD1–Mdm2/p53 positive feedback loop
- The suppressed proliferation and premature senescence by ganciclovir in p53-mutated human non-small-lung cancer cells acquiring herpes simplex virus-thymidine …
- Shifting p53-induced senescence to cell death by TIS21/BTG2/Pc3 gene through posttranslational modification of p53 protein
- p53 restoration in induction and maintenance of senescence: differential effects in premalignant and malignant tumor cells
- … mediated by increased DNA binding activity and increased interaction between p53 and Sp1 via phosphorylation during replicative senescence of human embryonic …
- The CEACAM1 tumor suppressor is an ATM and p53-regulated gene required for the induction of cellular senescence by DNA damage
- p53 in bronchial club cells facilitates chronic lung inflammation by promoting senescence
- A p53/ARF-dependent anticancer barrier activates senescence and blocks tumorigenesis without impacting apoptosis
- Regulation of cellular senescence via the FOXO4‐p53 axis
- Resistance of primary cultured mouse hepatic tumor cells to cellular senescence despite expression of p16Ink4a, p19Arf, p53, and p21Waf1/Cip1
- Suppression of senescence in normal human fibroblasts by introduction of dominant-negative p53 mutants or human papilloma virus type 16 E6 protein
- p53-dependent senescence in mesenchymal stem cells under chronic normoxia is potentiated by low-dose γ-irradiation
- Glutaredoxin-1 silencing induces cell senescence via p53/p21/p16 signaling axis
- Combined therapies that induce senescence and stabilize p53 block melanoma growth and prompt antitumor immune responses
- Aberrant anaplastic lymphoma kinase activity induces a p53 and RB-dependent senescence-like arrest in the absence of detectable p53 stabilization
- Genetic interrogation of replicative senescence uncovers a dual role for USP28 in coordinating the p53 and GATA4 branches of the senescence program
- p53 shares an antigenic determinant with proteins of 92 and 150 kilodaltons that may be involved in senescence of human cells.
- Mechanisms of cellular senescence by tumor suppressor p53
- Research advances on the relationship between cell senescence and oxidative stress, p16, p53/p 21
- Actin-binding doliculide causes premature senescence in p53 wild type cells
- MicroRNA-16 feedback loop with p53 and Wip1 can regulate cell fate determination between apoptosis and senescence in DNA damage response
- Inhibition of Twist1-mediated invasion by Chk2 promotes premature senescence in p53-defective cancer cells
- LncRNA‑mediated SIRT1/FoxO3a and SIRT1/p53 signaling pathways regulate type II alveolar epithelial cell senescence in patients with chronic obstructive …
- Downregulation of B‐myb promotes senescence via the ROS‐mediated p53/p21 pathway, in vascular endothelial cells
- SIRT1 reverses senescence via enhancing autophagy and attenuates oxidative stress-induced apoptosis through promoting p53 degradation
- Ectopic AP4 expression induces cellular senescence via activation of p53 in long-term confluent retinal pigment epithelial cells
- … Not Affect the Overexpression of p21WAF‐1 after Exposure of IMR‐90 hTERT Fibroblasts to a Sublethal Concentration of H2O2 Leading to Premature Senescence
- Cellular senescence in mouse hippocampus after irradiation and the role of p53 and p21
- The PPARγ‐SETD8 axis constitutes an epigenetic, p53‐independent checkpoint on p21‐mediated cellular senescence
- A simple stochastic model for the feedback circuit between p16INK4a and p53 mediated by p38MAPK: implications for senescence and apoptosis
- Senescence process in primary Wilms’ tumor cell culture induced by p53 independent p21 expression
- Hydroxylated-graphene quantum dots induce cells senescence in both p53-dependent and-independent manner
- Accumulation of smooth muscle 22α protein accelerates senescence of vascular smooth muscle cells via stabilization of p53 in vitro and in vivo
- Cytoplasmic E3 ubiquitin ligase CUL9 controls cell proliferation, senescence, apoptosis and genome integrity through p53
- Effect of lycium bararum polysaccharides on angiotensin II-induced senescence of human umbilical vein endothelial cells and expressions of p53 and P16
- Gallotannin is a DNA damaging compound that induces senescence independently of p53 and p21 in human colon cancer cells
- Tris (2-chloroethyl) phosphate induces senescence-like phenotype of hepatocytes via the p21Waf1/Cip1-Rb pathway in a p53-independent manner
- Activation of p53/p21waf1 pathway is associated with senescence during v-Ha-ras transformation of immortal C2C12 myoblasts.
- Cyclic mechanical tension reinforces DNA damage and activates the p53-p21-Rb pathway to induce premature senescence of nucleus pulposus cells
- p53 levels govern the choice between senescence and quiescence
- Acute loss of DP1, but not DP2, induces p53 mRNA and augments p21Waf1/Cip1 and senescence
- p53_growth_suppression.pdf#page=214″>Non-apoptotic responses to anticancer agents: Mitotic catastrophe, senescence and the role of p53 and p21
- Acute HSF1 depletion induces cellular senescence through the MDM2-p53-p21 pathway in human diploid fibroblasts
- Linking Nek6 to p53-induced senescence
- p41-Arc, a regulatory subunit of Arp2/3 complex, can induce premature senescence in the absence of p53 and Rb
- Effect of CCNB1 silencing on cell cycle, senescence, and apoptosis through the p53 signaling pathway in pancreatic cancer
- p53 shares an antigenic determinant with proteins of 92 and 150 kilodaltons that may be involved in senescence of human cells.
- Nore1a drives Ras to flick the p53 senescence switch
- Caveolin‑1 regulates oxidative stress‑induced senescence in nucleus pulposus cells primarily via the p53/p21 signaling pathway in vitro
- Hydrogen alleviates cellular senescence via regulation of ROS/p53/p21 pathway in bone marrow-derived mesenchymal stem cells in vivo
- Par-4-dependent p53 up-regulation plays a critical role in thymoquinone-induced cellular senescence in human malignant glioma cells
- Effect of silencing p53 and p21 on delaying senescence of nucleus pulposus cells
- Gadd45a gene silencing by RNAi promotes cell proliferation and inhibits apoptosis and senescence in skin squamous cell carcinoma through the p53 signaling …
- The imidazoacridinone C-1311 induces p53-dependent senescence or p53-independent apoptosis and sensitizes cancer cells to radiation
- LRP6 targeting suppresses gastric tumorigenesis via P14ARF–Mdm2–p53-dependent cellular senescence
- Immortalized mouse embryo fibroblasts are resistant to miR-290-induced senescence regardless of p53 status
- Correction: RNA-binding protein FXR1 regulates p21 and TERC RNA to bypass p53-mediated cellular senescence in OSCC
- Repeated stimulation by LPS promotes the senescence of DPSCs via TLR4/MyD88-NF-κB-p53/p21 signaling
- N-acetylcysteine ameliorates cisplatin-induced renal senescence and renal interstitial fibrosis through sirtuin1 activation and p53 deacetylation
- Role of p53-senescence induction in suppression of LNCaP prostate cancer growth by cardiotonic compound bufalin
- CSL-p53: From senescence to CAF activation
- Farnesyltransferase inhibitor induces p53-dependent cellular senescence in colon cancer cells
- PGE2 mediates senescence-induced inflammation in COPD lung fibroblasts via an EP2/p53 pathway
- Abstract B1: p53 isoforms, Δ133p53 and p53β, regulate aging-associated T lymphocyte senescence.
- The Influence of Overexpression of Wild Type p53 and UVB Radiation on Senescence of Human Skin Fibroblasts [J]
- Abstract A06: NORE1A is a double-barreled Ras senescence effector linking Ras to p53 and Rb
- Effect of microRNA-34a/SIRT1/p53 signal pathway on notoginsenoside R₁delaying vascular endothelial cell senescence
- Excess centrosomes induce p53-dependent senescence without DNA damage in endothelial cells
- Pharmacological DNA-PK inhibition induces ATM/p53 dependent premature senescence with immunomodulatory phenotype in irradiated cancer cells
- ASF1a inhibition induces p53-dependent growth arrest and senescence of cancer cells
- The p53/miRNAs/Ccna2 pathway serves as a novel regulator of cellular senescence: Complement of the canonical p53/p21 pathway
- … of human melanocytes to UVB twice and subsequent incubation leads to cellular senescence and senescence-associated pigmentation through the prolonged p53 …
- Differential radiation sensitivity in p53 wild-type and p53-deficient tumor cells associated with senescence but not apoptosis or (nonprotective) autophagy
- ALDH2 mediates the dose-response protection of chronic ethanol against endothelial senescence through SIRT1/p53 pathway
- Interleukin‑10 promotes primary rat hepatic stellate cell senescence by upregulating the expression levels of p53 and p21
- WITHDRAWN: Hexavalent chromium induces premature senescence through reactive oxygen species-mediated p53 pathway in L-02 hepatocytes
- Combined treatment with CCI779 and SB203580 induces cellular senescence in renal cell carcinoma cell line via p53 pathway
- Conjugated Physiological Resveratrol Metabolites Induce Senescence in Breast Cancer Cells: Role of p53/p21 and p16/Rb Pathways, and ABC Transporters
- Upregulation of MiR-126 Delays the Senescence of Human Glomerular Mesangial Cells Induced by High Glucose via Telomere-p53-p21-Rb Signaling Pathway
- Transcription of the tumor suppressor genes p53 and RB in lymphocytes from patients with chronic kidney disease: evidence of molecular senescence?
- … species induced by the compound bisphenol-a-diglycidylether cause senescence and apoptosis in colorectal cancer cell lines regardless of MDR1 or p53 …
- p53 restoration leads to tumor senescence and regression: implications for cancer therapy
- 23 SV40 oncoproteins and p53 deficiency impair stress-induced mesothelial cell senescence
- Senescence. Telomere, mitochondria and p53
- Methylseleninic acid super-activates p53 senescence axis as a preventive barrier to prostate tumorigenesis driven by Pten deficiency in vivo.
- p53 isoform delta133p53 in tumor senescence
- Comparative induction of p53-regulated gene expression by replicative senescence, pharmacological senescence, and DNA damage
- Inflammation, senescence and cancer: interweaving microRNA, inflammatory cytokines and p53 networks
- The role of Mip130/LIN-9, a cell cycle regulator, in the p19ARF/MDM2/p53 senescence pathway
- Role of mitochondria elongation in p53-induced cellular senescence
- Overexpression of MnSOD induces mitochondrial depolarization and p53-dependent senescence
- Critical roles of p53 and p16 in selenium-induced senescence
- Abstract A20: Excess centrosomes induce p53-dependent senescence in endothelial cells
- Cigarette Smoke Induces Cellular Senescence Via p53-Mediated Werner’s Syndrome Protein
- Abstract B30: Identification of new regulator in p53-mediated cellular senescence
- 1, 25‐Dihydroxyvitamin D exerts an antiaging role by activation of Nrf2‐antioxidant signaling and inactivation of p16/p53‐senescence signaling
- p53 gene expression is epigenetically regulated during replicative senescence in keratinocytes
- Inflammation, senescence and cancer: interweaving microRNA, inflammatory cytokines and p53 networks
- p53 isoforms Δ133p53 and p53β are endogenous regulators of replicative cellular senescence
- Vitamin C inhibits p53-induced senescence by preventing ROS generation and p38 MAPKinase activation
- The role of p53 induced cellular senescence in age related disorders.
- Hyperoxic Exposure Increases Senescence in Type II-Like Mouse Lung Epithelial Cells: Role of p53 Signaling
- Rapid senescence induced by overexpression of p53 in NIH3T3 cells
- Abstract# SY15-4: Functions of p53 in cell senescence and survival
- CS-33DISCOVERY OF A p53-INDEPENDENT SUPPRESSOR OF SENESCENCE OF GLIOBLASTOMA MULTIFORME
- Transient p53-Mediated Regenerative Senescence in the Injured Heart
- Influence of RNA interference-induced repression of p53 expression on senescence in human skin fibroblasts
- SENP3 Postpones Cellular Senescence of p53-mediated Pathway under Mild Oxidative Stress
- p53-dependent, replicative cell senescence suppresses chronic hypoxia-Induced pulmonary hypertension in mice
- p53 action in apoptosis and senescence
- Activation of p53 by radiation and induction of senescence-like growth arrest
- The role of the p53 target Wig-1 in senescence and cancer
- p53-is-a-barrier-to-environmentalcarcinogenesis-37237.html”>Cellular Senescence Controlled by p53 is a Barrier to Environmental Carcinogenesis
- Abstract SY14-02: p53-mediated senescence impairs the apoptotic response to chemotherapy in breast cancer
- Molecular Mechanisms of p53-and ROS-induced senescence
- Abstract# 1702: Molecular basis for the accelerated senescence response to doxorubicin in p53 wild-type and p53 null/mutant breast tumor cells.
- Sirt1 antagonizes Stra13 Mediated p53 Acetylation and Senescence
- Role of p53 in Mammary Epithelial Cell Senescence
- Loss of Adipocyte MDM2 Causes Lipodystrophy by Inducing p53-Dependent Apoptosis and Senescence
- Supplemental Data Significant Role for p16INK4a in p53-Independent Telomere-Directed Senescence
- The p53-MDM2-Rb network in controlling cell growth, apoptosis and senescence
- TAp63 induces cellular senescence and blocks Ras-driven tumor formation through p53-depdendent and-indepdendent mechanisms
- The role of DEC1 in p53-dependent cellular senescence
- P19 ARF-p53 Tumor Suppressor Pathway During Oncogene-Induced Apoptosis and Senescence
- Differential efficacy of p53 restoration in induction and maintenance of senescence in premalignant and malignant cells
- p53 induces senescence in the unstable progeny of aneuploid cells
- Bisphenol A exposure under metabolic stress induces accelerated cellular senescence in vivo in a p53 independent manner
- Identification of novel p53-target genes and their physiological roles in tumor suppression and cellular senescence.
- A novel DNA damage-induced alternative splicing pathway that regulates p53 and cellular senescence markers
- Cellular Senescence Controlled by p53 is a Barrier to Environmental Carcinogenesis
- p53 restoration in liver carcinomas induces cellular senescence and tumor clearance through an innate immune response
- Modulating Effects and Mechanisms of p53-miR-34a-SIRT1 Feedback Loop on Reproductive Senescence of Vascular Endothelial Progenitor Cells
- Cellular senescence as a tumor suppressor mechanism is mediated by sequential activation of the p53 and RB pathways
- p53-dependent stromal senescence-induced tumor dormancy in the pre-metastatic reservoir thymus
- Genome–Epigenome–Senescence: Is TET1 a Caretaker of p53-Injured Lung Cancer Cells?
- … DECISIONS: SENESCENCE, REPAIR, AND REGENERATION: Plasminogen Activator Inhibitor-1 Induces Alveolar Type 2 Cell Senescence Through Activating p53 …
- Abstract A33: A whole genome RNAi screen identifies BRD7 and BAF180 as p53 regulators required for senescence
- Abstract PR08: Autophagic degradation of Δ133p53 during replicative cellular senescence: An isoform-specific protein degradation mechanism for p53
- Id4 acts as a tumor suppressor by inducing apoptosis and senescence in p53-dependent manner
- Overexpression of the 58-kDa microspherule protein (MSP58) triggers cellular senescence via the p53-p21 signaling axis
- ITGB 4 deficiency induces senescence of airway epithelial cells through p53 activation
- p53 induces senescence through Lamin A/C stabilization-mediated nuclear deformation
- Correction: NLRP6 targeting suppresses gastric tumorigenesis via P14ARF–Mdm2–p53-dependent cellular senescence
- The Mdm2-a splice variant alters development, lifespan, cellular growth and senescence in a p53-dependent manner
- Targeting NEK2 Induces Cellular Senescence in B-Cell Malignancies through p53-Independent Signaling Pathways
- Olaparib induced senescence under P16 or p53 dependent manner in ovarian cancer
- Synaptotagmin-7, a binding protein of p53, inhibits the senescence and promotes the tumorigenicity of lung cancer cells
- Plasminogen Activator Inhibitor-1 Induces Alveolar Type 2 Cell Senescence Through Activating p53-P21-Rb Pathways In Vitro And In Vivo
- Dissecting the function of p53 in cellular senescence by identification and characterization of p53 target genes
- CARF Regulates Cellular Senescence and Apoptosis through p53-Dependent and-Independent Pathways
- Loss of MECP2 leads to induction of p53 and cell senescence
- Susceptibility to Radiation Induced Apoptosis and Senescence in p53 Wild Type and p53 Mutant Breast Tumor Cells
- Coagulation Factor Xa Promotes Endothelial Cell Senescence Via p53 Up-regulation
- Abstract SY02-02: Tumor suppression in the absence of p53-mediated cell cycle arrest, apoptosis, and senescence.
- Notch Signaling Regulates Vascular Endothelial Cell Senescence via a p53-Dependent Pathway
- Chromatin interacting proteins RBL2/p130, MRG15 and p53 in cellular senescence
- p53 Isoforms in Cellular Senescence-and Ageing-Associated Biological and Physiological Functions
- Oncogene-induced senescence and the role of p53 in BRAFV600E melanoma
- Ionizing radiation-induced senescence of breast tumor cells is dependent on p53 and associated with telomere dysfunction.
- Sharp-1 Mediates p53-dependent cellular senescence through antagonism of Sirt1
- Hsp90β interacts with MDM2 to suppress p53‐dependent senescence during skeletal muscle regeneration
- p53 regulates mitochondrial dynamics by inhibiting Drp1 translocation into mitochondria during cellular senescence
- … RECEPTOR BLOCKER, FIMASARTAN REDUCES VASCULAR SMOOTH MUSCLE CELL SENESCENCE BY INHIBITING CYR61 AND ERK/P38MAPK/p53 …
- Abstract# 3478: Diminution of p53 during cellular senescence and organismal aging in normal human keratinocytes occurs at the post-transcriptional level
- MDM2-mediated degradation of WRN promotes cellular senescence in a p53-independent manner
- P4500 Cellular senescence of endothelial cells impairs angiogenesis by altering energy metabolism through p53-tigar axis
- Induction of p53 Dependent Cellular Senescence Through HdmX Inhibition or YPEL3 Expression
- TIS21/BTG2/PC3 triggers cancer cell death, instead of cellular senescence, by enhancing proapoptotic gene expression at the downstream of p53
- A retroviral tamoxifen-inducible human Tp53ER protein activates a conserved p53 response but fails to promote senescence in mouse fibroblasts
- Human colorectal cancer derived-MSCs promote tumor cells escape from senescence via p53/P21 pathway
- Depletion of GAPDH promotes p53 signaling, cell senescence and altered response to chemotherapeutic agents in human carcinoma cells
- In Cellular Senescence, the Third Circle of the Cell Life’s Network, p53 Acts Vital Role
- Induction of p53-mediated senescence is essential for the eventual anticancer therapeutic effect of RH1
- Abstract# 3473: Down regulation of HDAC2 in senescent fibroblasts involves cellular senescence through induction of p53 independent p21cip1/sdi1 transactivation
- TIS21 shifts p53-induced response of EJ bladder carcinoma cells from senescence to apoptosis
- Depletion of TRRAP induces p53‐independent senescence in liver cancer by downregulating mitotic genes
- 17β-estradiol inhibits human umbilical vascular endothelial cell senescence by regulating autophagy via p53
- The Kindlin2-p53-SerpinB2 signaling axis is required for cellular senescence in breast cancer
- Corrigendum: Genetic interrogation of replicative senescence uncovers a dual role for USP28 in coordinating the p53 and GATA4 branches of the senescence …
- Abstract LB-082: The Kindlin2-p53-SerpinB2 signaling axis is required for the regulation of cellular senescence in breast cancer
- l-Carnitine inhibits the senescence-associated secretory phenotype of aging adipose tissue by JNK/p53 pathway
- ID: 1051 Telomerase activity, telomere length and p53 mutation detection on cellular senescence of Human Amnion Mesenchymal Stem Cells (HAMCs)
- Time-dependent p53 inhibition determines senescence attenuation and long-term outcome after renal ischemia-reperfusion
- The TGF-β1/p53/PAI-1 Signaling Axis in Vascular Senescence: Role of Caveolin-1
- Influence of RNA interference in p53 gene on the expressions of genes involved in ultraviolet B-induced premature senescence and photocarcinogenesis in human …
- Involvement of p53 in senescence arrest and caspase 3 activity in the cell death response to methotrexate in the breast tumor cell
- Inhibition of DYRK1A-EGFR axis by p53-MDM2 cascade mediates the induction of cellular senescence
- … II-INDUCED CELLULAR SENESCENCE IN HUMAN CORONARY ARTERY SMOOTH MUSCLE CELLS BY INHIBITING CYR61 AND ERK/P38MAPK/p53 SIGNALING …
- … MECHANISMS THAT LINK AGING WITH LUNG DISEASE: THE CUTTING EDGE: Acrolein Induces p53-Mediated Cellular Senescence Accompanied By Enhanced …
- CALB1 enhances the interaction between p53 and MDM2, and inhibits the senescence of ovarian cancer cells
- Induction of a p21 mediated senescence program by p53 impairs the apoptotic response to chemotherapy and clinical outcome in breast cancer
- Atrial Fibrillation Progression Is Associated with Cell Senescence Burden as Determined by p53 and p16 Expression
- Retraction: Interferon-β Induces Cellular Senescence in Cutaneous Human Papilloma Virus-Transformed Human Keratinocytes by Affecting p53 Transactivating …
- Possible role of cellular senescence in the pathogenesis of psoriasis–expression of 53BP1, γH2AX, p16, p21 and p53 in lesional psoriatic skin
- Methotrexate-induced senescence of human colon cancer cells depends on p53 acetylation, but not genomic aberrations
- BMI1 and dominant negative p53 cooperate to suppress AKT-mediated oncogene-induced senescence and promote transformation in human neural stem cells.
- PM 10 from Mexico City (MC) induce senescence-like phenotype and ATM, γH2A. X and p53 activation linked to oxidative stress
- Vascular Senescence Promotes the Development of Insulin Resistance: Role of Endothelial p53 in Glucose Metabolism
- Interleukin-10 induces senescence of activated hepatic stellate cells via STAT3-p53 pathway to attenuate liver fibrosis
- Decline of p300 contributes to cell senescence and growth inhibition of hUC-MSCs through p53/p21 signaling pathway
- P4239Bradykinin inhibits High Glucose-Induced Senescence of c-kit Positive Cardiac Stem Cells via B2R/PI3K/AKT/mTOR/p53 signal pathway
- Small molecule inhibitor of MDM2 induces p53-dependent HMGB1 secretion followed by apoptosis in cancer cells and incomplete senescence in normal fibroblasts
- Sirtuin 2 expression suppresses oxidative stress and senescence of nucleus pulposus cells through inhibition of the p53/p21 pathway
- circ LARP 4 induces cellular senescence through regulating miR‐761/RUNX 3/p53/p21 signaling in hepatocellular carcinoma
- 20 (S)-Ginsenoside Rg3 Promotes Senescence And Apoptosis In Gallbladder Cancer Cells Via The p53 Pathway [Corrigendum]
- Abstract A060: Inhibition of Aurora B kinase activity triggers senescence that can be bypassed by blocking p53 and RB function, promoting replication stress
- Wild-type p53-induced phosphatase 1 (Wip1) prevents cellular senescence at physiological oxygen levels by regulating DNA damage signaling during DNA …
- MicroRNA‐145 induces the senescence of activated hepatic stellate cells through the activation of p53 pathway by ZEB2
- Negative regulation of p53-induced senescence by N-WASP is crucial for DMBA/TPA-induced skin tumor formation
- Avenanthramide A Induces Cellular Senescence via miR-129-3p/Pirh2/p53 Signaling Pathway To Suppress Colon Cancer Growth
- Abstract P1-04-03: A Role for Cyclin D1 in Neoplastic Transformation in MCF-7 Breast Cancer Cells Post p14ARF-p53 Induced Senescence
- Mitotic catastrophe and p53-dependent senescence induction in T-cell malignancies exposed to nonlethal dosage of GL-V9
- Upregulation of the p53-p21 pathway by G2019S LRRK2 contributes to the cellular senescence and accumulation of α-synuclein
- p53 loss does not permit escape from BrafV600E-induced senescence in a mouse model of lung cancer
- Jun dimerization protein 2 controls hypoxia‐induced replicative senescence via both the p16Ink4a‐pRb and Arf‐p53 pathways
- Caveolin-1 mediated p53 activation in stress induced premature senescence and its antagonistic pleiotropic implications in cancer
- 0359: Cyclosporine A prevents the induction of replicative senescence in cultured coronary artery endothelial cells: role of eNOS-derived NO and the p53/p21 and p16 …
- The p53-p21 pathway is necessary for cellular senescence induced by the inhibition of protein kinase CKII in human colon cancer cells.
- TDF-ß signaling engages an ATM-CHK2-p53-independent RAS-induced senescence and prevents malignant transformation in human mammary epithelial …
- Dephosphorylation of p53 Ser 392 Enhances Trimethylation of Histone H3 Lys 9 via SUV39h1 Stabilization in CK2 Downregulation-Mediated Senescence
- Supplemental Data Telomere Shortening Triggers Senescence of Human Cells through a Pathway Involving ATM, p53, and p21CIP1, but Not p16INK4a
- Role of tea polyphenols in delaying hyperglycemia-induced senescence in human glomerular mesangial cells via miR-126/Akt–p53–p21 pathways
- The synergistic action of phosphate and interleukin-6 enhances senescence-associated calcification in vascular smooth muscle cells depending on p53
- Insulin-like growth factor-1 attenuates oxidative stress-induced hepatocyte premature senescence in liver fibrogenesis via regulating nuclear p53–progerin …
- Abstract C34: Senescence as a mechanism of resistance to the Aurora kinase and angiokinase inhibitor, ENMD-2076, in p53 mutated triple-negative breast cancer …
- C2-Ceramide-Induced Rb-Dominant Senescence-Like Phenotype Leads to Human Breast Cancer MCF-7 Escape from p53-Dependent Cell Death
- Loss of Cdh1 Triggers Premature Senescence in Part via Activation of Both the RB/E2F1 and the CLASPIN/CHK1/p53 Tumor Suppressor Pathways
- … anti-TOPO-1-containing sera from systemic sclerosis-related diseases with Raynaud’s phenomenon induce vascular endothelial cell senescence not via classical p53 …
- TZAP plays an inhibitory role in the self-renewal of porcine mesenchymal stromal cells and is implicated the regulation of premature senescence via the p53 …
- Roberson RS, Kussick SJ, Vallieres E, Chen SY, Wu DYEscape from therapy-induced accelerated cellular senescence in p53-null lung cancer cells and in …
- Epigenetic regulation and molecular mechanisms of cellular senescence by tumor suppressor p53
- Editorial comment on ‘A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy’by Schmitt et al.
- However, cells that use Myc or loss of RB/p53 to circumvent senescence will eventually experience rampant genome instability due to the loss of their …
- Hyperglycemia-induced endothelial senescence mediated by the p53 deacetylase SIRT1 contributes to diabetic vasculopathy
- … EGFR and Mutant p53 Facilitates Epithelial-Mesenchymal Transition By Negating Oncogene-Activated Cellular Senescence in Transformed Human …
- OC-0050: Radiation-induced endothelial senescence is under the control of p53 and mitochondrial dysfunction
- Replicative Senescence of Human Oral Keratinocytes, Telomerase, Telomere, p53 and p21WAF¹/CIP¹
- P180 HEME OXYGENASE-1 PREVENTS VASCULAR SENESCENCE THROUGH MECHANISMS INVOLVING ROS/SIRT1/p53 PATHWAY IN AGED …
- Mo1744–Nlrp6 Targeting Suppresses Colonic Tumorigenesis Via p53-Dependent and Independent Cellular Senescence
- Sa1790 p53-Dependent Senescence Suppresses the Proliferation of Esophageal Epithelial Cells With Acetaldehyde-Derived DNA Damage
- Sa1715 Regulation of Cellular Senescence by the microRNA-34a/p53 Axis During Alcoholic Liver Injury
- Acrolein Induces p53-Mediated Cellular Senescence Accompanied By Enhanced Werner’s Syndrome Protein Degradation And Telomere Shortening
- H2O2 accelerates cellular senescence by accumulation of acetylated p53 via decrease in the function of SIRT1 by NAD [+] depletion
- Induction of Premature Senescence in Cardiomyocytes by Oxidative Stress Via PML-acetylated p53 Pathway in Cardiomyocytes
- p53 restoration in liver carcinomas induces cellular senescence and tumor clearance through an innate immune response
- CHIP ligase plays a central role in p53 regulation during senescence
- Altered expression of p53 ubiquitin ligases in human senescence
- 217 Localization of Phosphorylated H2AX and Phosphorylated p53 in Cells Inducing X-ray-induced Senescence-like Growth Arrest (Physics, chemistry …
- Telomere function and p16/RB and p53-mediated senescence pathways in human cancer
- Partial proteasome inhibition triggers p53-dependent premature senescence
- CARF is a novel regulator of p53 pathway that controls senescence and apoptosis
- RB and p53 Regulate Cell Proliferation, Cell Senescence and Apoptosis in Human Vascular Smooth Muscle Cells from Atherosclerotic Plaques
- ARF, p53 AND THE CONTROL OF CELLULAR SENESCENCE IN MOUSE MELANOCYTES.
- PJ-149 Hyperglycemia-induced Senescence of Endothelial Cells through the p53 Deacetylase SIRT1 (Diabetes/Obesity/Metabolic syndrome-10 (H) PJ25 …
- Protein Kinase CKII Inhibition-Induced Senescence is p53-Dependent
- … A Induces DNA Double Strand Break and Activates the ATM-p53-GDF15 Signaling Pathway Leading to Cell Cycle Arrest and Senescence in Human Fetal …
- FRS-071 Premature Senescence can be Induced by Oxidative Stress via PML-p53 Acetylation Pathway in Cardiomyocytes (Heart Failure Research (M) …
- mTOR directly phosphorylates p53 in PTEN-loss-induced cellular senescence
- ISDN2014_0058: p63 and p73 coordinate p53 function to determine the balance between survival, cell death and senescence in adult neural precursor …
- The relative contributions of the p53 and pRb pathways in oncogene-induced melanocyte senescence
- GW29-e0204 Bradykinin Inhibits High-Glucose-Induced Senescence of Cardiac Progenitor Cells through the B2R/PI3K/AKT/mTOR/p53 Signal Pathways
- Senescence-related expression of p53 ligases
- Study on the mechanism of p53 family-mediated senescence= p53 단백질군에 의한세포노화의 기작에 관한 연구
- TIS21 shifts H-RasV12 oncogene-induced senescence to apoptosis in EJ bladder cancer cells in a p53 dependent manner
- p53 expression in the senescence induced with H2O2 in gastric epithelial cell
- Localization of Phosphorylated H2AX and Phosphorylated p53 in Cells Inducing X-ray-induced Senescence-like Growth Arrest
- Imidazoacridinone derivative C-1311 (SymadexTM) induces apoptosis, mitotic catastrophe or senescence in human colon carcinoma HCT116 cells depending on p53 …
- SCF (Fbxo22)-KDM4A targets methylated p53 for degradation and regulates senescence (細胞老化過程における p53 標的遺伝子 Fbxo22 の機能解析)< 内容の…
- 4-methyl-1-nitroacridine derivative C-1748 induces apoptosis, mitotic catastrophe or senescence in human colon carcinoma HCT116 cells depending on p53 status
- Transcriptional coactivator Sp110 associates with p53 and regulates p53-dependent cellular senescence
- Aging & Cellular Senescence: A Molecular Mechanism of p53-induced Senescence
- … and Cancer: RHI, a bioreductive agent exerts its anti-cancer effect through both apoptosis and senescence accompanied with marked induction of p53
- Akt Induces Endothelial Cell Senescence via a p53/p21-Dependent Pathway
- p53 codon 72 polymorphism and longevity: additional data on centenarians from continental Italy and Sardinia
- Why do centenarians escape or postpone cancer? The role of IGF-1, inflammation and p53
- p53 variants predisposing to cancer are present in healthy centenarians.
- Metabolic gene polymorphisms and p53 mutations in healthy centenarians and younger controls
- Akt negatively regulates the in vitro lifespan of human endothelial cells via a p53/p21‐dependent pathway
- New nanoformulation of rapamycin Rapatar extends lifespan in homozygous p53−/− mice by delaying carcinogenesis
- New tricks of an old molecule: lifespan regulation by p53
- p53/CEP‐1 increases or decreases lifespan, depending on level of mitochondrial bioenergetic stress
- Telomere-based proliferative lifespan barriers in Werner-syndrome fibroblasts involve both p53-dependent and p53-independent mechanisms
- Loss of p53 function accelerates acquisition of telomerase activity in indefinite lifespan human mammary epithelial cell lines
- Sequential extension of proliferative lifespan in human fibroblasts induced by over-expression of CDK4 or 6 and loss of p53 function
- Cockayne syndrome B protein (CSB): linking p53, HIF-1 and p300 to robustness, lifespan, cancer and cell fate decisions
- Systemic Akt1 deletion after tumor onset in p53−/− mice increases lifespan and regresses thymic lymphoma emulating p53 restoration
- Impaired p53/CEP‐1 is associated with lifespan extension through an age‐related imbalance in the energy metabolism of C. elegans
- The late effects of radiation on lifespan, lymphocyte proliferation and p53 haplodeficiency in mice
- Polμ deficiency induces moderate shortening of p53−/− mouse lifespan and modifies tumor spectrum
- The Mdm2-a splice variant alters development, lifespan, cellular growth and senescence in a p53-dependent manner
- Results-II. Haploinsufficiency of p53 Rescues Lifespan and Premature Aging-Associated Abnormalities in Sirt6-Deficient Mice
- AKT NEGATIVELY REGULATES HUMAN ENDOTHELIAL CELL LIFESPAN VIA THE p53/P21 DEPENDENT PATHWAY
- Akt negatively regulates the in vitro lifespan of human endothelial Cells via a p53/p21-dependent pathway
- The effects of p53 on whole organism longevity are mediated by autophagy
- p53: guardian AND suppressor of longevity?
- Tumor suppressor p53 Arg72Pro polymorphism and longevity, cancer survival, and risk of cancer in the general population
- The common germline Arg72Pro polymorphism of p53 and increased longevity in humans
- p53: Pro-aging or pro-longevity?
- The pro-longevity gene FoxO3 is a direct target of the p53 tumor suppressor
- Reduced Expression of the Caenorhabditis elegans p53 Ortholog cep-1 Results in Increased Longevity
- The regulation of aging and longevity: a new and complex role of p53
- p53 codon 72 polymorphism and longevity: additional data on centenarians from continental Italy and Sardinia
- The p53–Mdm2 feedback loop protects against DNA damage by inhibiting p53 activity but is dispensable for p53 stability, development, and longevity
- Using mice to examine p53 functions in cancer, aging, and longevity
- Altered longevity‐assurance activity of p53: p44 in the mouse causes memory loss, neurodegeneration and premature death
- Lower antioxidant capacity and elevated p53 and p21 may be a link between gender disparity in renal telomere shortening, albuminuria, and longevity
- Rapamycin as longevity enhancer and cancer preventative agent in the context of p53 deficiency
- A role for p53 in mitochondrial stress response control of longevity in C. elegans
- Longevity regulation in flies: a role for p53
- CEP-1, the Caenorhabditis elegans p53 homolog, mediates opposing longevity outcomes in mitochondrial electron transport chain mutants
- Sir2 and longevity: the p53 connection
- P44, the ‘longevity‐assurance’isoform of p53, regulates tau phosphorylation and is activated in an age‐dependent fashion
- p53, longevity assurance and longevity suppression
- Transcription factors CEP‐1/p53 and CEH‐23 collaborate with AAK‐2/AMPK to modulate longevity in Caenorhabditis elegans.
- Germline genetics of the p53 pathway affect longevity in a gender specific manner
- Are the conspicuous interdependences of fecundity, longevity and cognitive abilities in humans caused in part by p53?
- A polymorphism in the tumor suppressor p53 affects aging and longevity in mouse models
- p53: Pro-aging or pro-longevity?
- The impact of p53 codon 72 SNP upon aging and longevity in mouse models
- Role of p53 in Extending Longevity in Untransformed Fibroblasts
- p53_Codon_72_Polymorphism_and_Longevity_20161220-25567-4p981f.pdf”>p53 Codon 72 Polymorphism and Longevity: Additional Data on Centenarians from Continental Italy and…
- On the discovery and elucidation of the mechanism via which repression of the Caenorhabditis elegans p53 ortholog cep-1 results in longevity.
- Sirtuin1, a longevity gene, is over-expressed and enhances proliferation and survival of endometrial carcinoma cells via deacetylation of p53.
- On the discovery and elucidation of the mechanism via whichrepression of the Caenorhabditis elegans p53 ortholog cep-1 results in longevity
- Elephants, longevity, cancer and p53
- Glutathione depletion induces antioxidant response via the p53-mediated transcription of PGC-1a: a novel longevity pathway?
- allintitle: p53 Aging: 195 results; 37 citations w/ no links provided: 158 Links
- Two faces of p53: aging and tumor suppression
- Senescence and aging: the critical roles of p53
- The p53 network: cellular and systemic DNA damage responses in aging and cancer
- Does p53 affect organismal aging?
- p53, ROS and senescence in the control of aging
- p53, oxidative stress, and aging
- Increased p53 protein associated with aging in human diploid fibroblasts
- Tumor suppression and normal aging in mice with constitutively high p53 activity
- The impact of altered p53 dosage on hematopoietic stem cell dynamics during aging
- The Arf/p53 pathway in cancer and aging
- The tumor suppressor p53: cancer and aging
- Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform
- ATM‐dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post‐translational activation of p53 protein involving poly (ADP‐ribose) …
- Aging and chronic DNA damage response activate a regulatory pathway involving miR‐29 and p53
- Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program
- Declining p53 function in the aging process: a possible mechanism for the increased tumor incidence in older populations
- From telomere loss to p53 induction and activation of a DNA-damage pathway at senescence: the telomere loss/DNA damage model of cell aging
- p53 deletion impairs clearance of chromosomal-instable stem cells in aging telomere-dysfunctional mice
- p53: Pro-aging or pro-longevity?
- p53 as an intervention target for cancer and aging
- The regulation of aging and longevity: a new and complex role of p53
- DNA repair and aging: the impact of the p53 family
- Wnt/β-catenin signaling induces the aging of mesenchymal stem cells through the DNA damage response and the p53/p21 pathway
- Mdm2–p53 signaling regulates epidermal stem cell senescence and premature aging phenotypes in mouse skin
- Oxidative stress activates a specific p53 transcriptional response that regulates cellular senescence and aging
- p53 and aging: A fresh look at an old paradigm
- Accelerated development and aging of the immune system in p53-deficient mice
- Insights into aging obtained from p53 mutant mouse models
- Control of p53 and NF-κB signaling by WIP1 and MIF: role in cellular senescence and organismal aging
- Using mice to examine p53 functions in cancer, aging, and longevity
- p53 isoforms regulate aging-and tumor-associated replicative senescence in T lymphocytes
- Fragile fugue: p53 in aging, cancer and IGF signaling
- Complicating the role of p53 in aging
- Sun-exposure-and aging-dependent p53 protein accumulation results in growth advantage for tumour cells in carcinogenesis of nonmelanocytic skin cancer
- Altered senescence, apoptosis, and DNA damage response in a mutant p53 model of accelerated aging
- Cancer and aging: yin, yang, and p53.
- Glycolysis links p53 function with NF‐κB signaling: Impact on cancer and aging process
- DNA sequence variants of p53: cancer and aging
- Aging-associated truncated form of p53 interacts with wild-type p53 and alters p53 stability, localization, and activity
- Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 3. Inhibitory effect of SkQ1 on tumor development from p53 …
- p53 induces skin aging by depleting Blimp1+ sebaceous gland cells
- Oxidative damage to DNA, p53 gene expression and p53 protein level in the process of aging in rat brain
- Aging splenocyte and thymocyte apoptosis is associated with enhanced expression of p53, bax, and caspase-3
- cep-1/p53-dependent dysplastic pathology of the aging C. elegans gonad
- p53 pro-oxidant activity in the central nervous system: implication in aging and neurodegenerative diseases
- Loss of p53-mediated cell-cycle arrest, senescence and apoptosis promotes genomic instability and premature aging
- p53 mutations associated with aging-related rise in cancer incidence rates
- Pharmacogenetics and pharmagenomics, trends in normal and pathological aging studies: focus on p53
- Interaction between the Cockayne syndrome B and p53 proteins: implications for aging
- Recent discoveries in the cycling, growing and aging of the p53 field
- Mice deficient in Rbm38, a target of the p53 family, are susceptible to accelerated aging and spontaneous tumors
- It’s all about balance: p53 and aging
- Apurinic/apyrimidinic endonuclease 1, p53, and thioredoxin are linked in control of aging in C. elegans
- Anxiety and the aging brain: Stressed out over p53?
- Tumor suppression by p53 without accelerated aging: just enough of a good thing?
- Transient mitochondrial DNA double strand breaks in mice cause accelerated aging phenotypes in a ROS-dependent but p53/p21-independent manner
- SnoN activates p53 directly to regulate aging and tumorigenesis
- Dysfunction of the MDM2/p53 axis is linked to premature aging
- Relationship of telomeres and p53 in aging bovine corneal endothelial cell cultures
- Role of Sirtuin1-p53 regulatory axis in aging, cancer and cellular reprogramming
- Increased Arf/p53 activity in stem cells, aging and cancer
- Loss of androgen receptor in aging and oxidative stress through Myb protooncoprotein-regulated reciprocal chromatin dynamics of p53 and poly (ADP-ribose) …
- FGF21 represses cerebrovascular aging via improving mitochondrial biogenesis and inhibiting p53 signaling pathway in an AMPK-dependent manner
- Amelioration of premature aging in mtDNA mutator mouse by exercise: the interplay of oxidative stress, PGC-1α, p53, and DNA damage. A hypothesis
- Relevance of the p53–MDM2 axis to aging
- Multinucleated variant endothelial cells (MVECs) of human aorta: expression of tumor suppressor gene p53 and relationship to atherosclerosis and aging
- p53andaging-%20roleofp66Shc-%20impactaging.com%202013.pdf”>p53 and aging: role of p66Shc
- Control of cellular aging, tissue function, and cancer by p53 downstream of telomeres
- p53 and mouse aging models
- Modelling the p53/p66Shc aging pathway in the shortest living vertebrate Nothobranchius furzeri
- p53 isoforms regulate premature aging in human cells
- Altered S-nitrosylation of p53 is responsible for impaired antioxidant response in skeletal muscle during aging
- … expression of the p16 (INK4a)-Rb and p19 (Arf)-p53-p21 (Cip/Waf1) signaling pathways in the regulation of hematopoietic stem cell aging by ginsenoside Rg1
- p53 synthesis and phosphorylation in the aging diet-restricted rat following retinoic acid administration
- Delaying vascular aging with Chinese medicine: Implications from an overview of the p53 and miR-34s family
- Aging or tumor: The crosstalk between telomerase and p53
- The genetic architecture of aging: Sexual antagonistic plieotropy of p53 and foxo
- Transcription factor p53 and skin aging
- SirT3 and p53 deacetylation in aging and cancer
- Proliferative activity and expression of cyclin-dependent kinase inhibitor p21WAF1 and p53 protein in endothelial cells of human aorta during replicative aging in vitro
- p53-pathway.pdf”>USP22 down-regulation facilitates human retinoblastoma cell aging and apoptosis via inhibiting TERT/p53 pathway
- p53, sex, and aging: lessons from the fruit fly
- Apoptosis is induced in aging SV40 T antigen-transformed human fibroblasts through p53-and p21CIP1/WAF1-independent pathways
- Do p53 stress responses impact organismal aging?
- Yifuning postpones ovarian aging through antioxidant mechanisms and suppression of the Rb/p53 signal transduction pathway
- Dual signaling mechanisms of estrogen: Phosphorylation of p53 at Ser15 in aging HMEC in the absence of estrogen receptor
- Effect of Angelica sinensis polysaccharide on expression of telomere, telomerase and p53 in mice aging hematopoietic stem cells
- Commitment of protein p53 and amyloid-beta peptide (Aβ) in aging of human cerebellum
- A polymorphism in the tumor suppressor p53 affects aging and longevity in mouse models
- Therapeutic applications of p53 isoforms in regenerative medicine, aging and cancer
- Elevated levels of oxidative DNA damage activate p53 and caspases in brain of ayu with aging
- Influence of Electro-acupuncture of Yongquan-point on the Expression of p53 and bcl-2 in the Aging Model Rat Induced by D-dalactose
- The Dysfunctional MDM2–p53 Axis in Adipocytes Contributes to Aging-Related Metabolic Complications by Induction of Lipodystrophy
- DNA methylation and specific sequience motifs: association with genetics instability in p53 in cancer, and other loci in degenerative disorders and aging
- Between Scylla and Charybdis: p53 links tumor suppression and aging
- The p53 Pathway, Cancer and Aging
- Nervous System Aging, Degeneration, and the p53 Family
- DNA damage, p53 gene expression and p53 protein level in the rat brain aging
- Aging and p53: getting it straight A commentary on a recent paper by Gentry and Venkatachalam
- Therapeutic applications of p53 isoforms in regenerative medicine, aging and cancer
- EXPRESSIONS OF p53/Rb CELLULAR TRANSDUCTION PATHWAY RELATED GENES AND PROTEINS IN AGING RATS TESTES [J]
- p53-suppressed oncogene TET1 prevents cellular aging in lung cancer
- Abstract B1: p53 isoforms, Δ133p53 and p53β, regulate aging-associated T lymphocyte senescence.
- Therapeutic applications of p53 isoforms in regenerative medicine, aging and cancer
- Involvement of p53 and Bcl-2 in sensory cell degeneration in aging rat cochleae
- Effect of Heshouwuyin on Rb/p53 Signal Transduction Pathway in Brain Tissue Cells of Aging Rat [J]
- Moxibustion on Carbonyl Stress and Expression of p19ARF and p53 mRNA in Livers of D-galactose-Induced Aging Rats
- Polysaccharides from Athyrium multidentatum (Doll.) Ching an Attenuated d-Galactose-Induced Mouse Aging via SIRT1-p53-p21 Pathway
- It’s all about balance: p53 and aging
- Effect of Heshouwuyin on Rb/p53 signal transduction pathway in aging rat testis tissue cells
- Insights into stem cells and aging provided by a p53 mutant mouse
- p53: Pro-aging or pro-longevity?
- Unraveling the link between the Mdm2-p53 axis and aging
- p53 mediated transcription of Omi/HtrA2 in aging myocardium
- The role of p53 signaling pathway in aging and cancer
- An investigation of p53 in skeletal muscle aging
- Gene dosage and aging in lung tumorigenesis in p53 (273H) transgenic mice
- Cyclin D1 and p53 and their expression in human Leydig cells during aging
- The impact of p53 codon 72 SNP upon aging and longevity in mouse models
- The Effects of Ultraviolet Radiation on Aging and p53 Expression in Human Skin
- Silent information regulator 1 gene induces aging of hepatocellular carcinoma cells via p53/p21 pathway
- Role of telomere dysfunction, DNA damage response and p53 mutations in tumorigenesis and aging
- New Targets of p53 Regulation: From Aging to Immune Response
- Inhibition of Cytosolic p53 Preserves Mitochondrial Integrity and Prevents Cardiac Aging
- Estrogen-induced phosphorylation of p53 at Ser15 in aging HMEC in the absence of estrogen receptor
- Interleukin 6 Knockout Inhibits Aging-Related Accumulation of p53 in the Mouse Myocardium
- p53 Promotes Cardiac Aging Through The Inhibition Of Parkin Mediated Mitochondrial Quality Control
- Abstract# 596: p53 deletion impairs clearance of chromosomal instable stem cells and accelerates epithelial aging in telomere dysfunctional mice
- l-Carnitine inhibits the senescence-associated secretory phenotype of aging adipose tissue by JNK/p53 pathway
- Aging and DNA-damage response activate a regulatory pathway involving miR-29 and p53
- Results-II. Haploinsufficiency of p53 Rescues Lifespan and Premature Aging-Associated Abnormalities in Sirt6-Deficient Mice
- Aging and chronic DNA damage response activate a regulatory pathway involving miR-29 and p53
- Abstract# 3478: Diminution of p53 during cellular senescence and organismal aging in normal human keratinocytes occurs at the post-transcriptional level
- P1842 Repetitive postprandial glucose/triglyceride spikes activate p53 in bone marrow progenitor cells and induce premature aging of bone marrow
- p53 in metabolism, aging and cancer.
- THE ROLE OF THE p53/P66SHC PATHWAY IN DEVELOPMENT AND AGING: DANIO RERIO (ZEBRAFISH) AND NOTHOBRANCHIUS AS MODEL ORGANISMS
- Expression of Aβ42, τ-Protein, p16, p53 in Buccal Epithelium: Prospects for Use in the Diagnostics of Alzheimer’s Disease and Rate of Aging
- Influence of aging on the interaction of the PI3K survival pathway and the p53-mediated apoptosis pathway in a rat model of myocardial ischemia-reperfusion
- C21 MECHANISMS THAT LINK AGING WITH LUNG DISEASE: THE CUTTING EDGE: Acrolein Induces p53-Mediated Cellular Senescence Accompanied By …
- … plays a pivotal role in collateral development under ischemia by suppressing aging-induced production of oxidative stress, expression of p53 and pro-apoptotic …
- Cytotoxicity effects of tert-butyl hydroperoxide-induced p53-mediated cell-cycle arrest, apoptosis and aging in rat aortic endotheial cells and aorta: inhibition by …
- … Plays a Pivotal Role in Collateral Development Under Ischemia by Suppressing Aging-Induced Production of Oxidative Stress, Expression of p53 and Pro-Apoptotic …
- Effects of electroacupuncture of yongquan acupoint on the expression of p53 and bcl-2 in aging model rats
- Is p53 a key to understanding the distinction of aging process between normal human and rodent cells?
- Aging, p53 and the ’24 gene mutant’: getting it right A reply to Vijg and Hasty
- Mitochondrial DNA damage contributes to premature aging through p53-dependent response mechanisms
- TheHarlequinMouse Model of Premature Aging Displays Increased p53 Signalling, Evidence of Vascular Dysfunction and Inflammation in the Retina and …
- REGc DEFICIENCY PROMOTES PREMATURE AGING VIA A CK1D-MDM2-p53 PATHWAY
- The p53 family in neurodegeneration, aging, and neural stem cell function
- Mechanism of p53-mediated aging and metabolism
- < SYMPOSIUM: Biology of Aging and Age-associated Skin Disorders> TELOMERASE ACTIVITY, p53 VS BCL-2 EXPRESSION AND APOPTOSIS IN HUMAN SKIN …
- … act as a negative regulator of aging in human gingival fibroblast via p53 and Sp1 transcription factors= 히스톤 탈아세틸화 효소인 HDAC1 과 HSIR2 는 p53 과 Sp1 전사 …
- Aging and Cancer: RHI, a bioreductive agent exerts its anti-cancer effect through both apoptosis and senescence accompanied with marked induction of …
- Aging and Cancer: p53 mediated apoptosis
- Aging & Cellular Senescence: A Molecular Mechanism of p53-induced Senescence
- Aging and Cancer: Statin induces p53-dependent ER stress and apoptosis
- Aging and Cancer: Simvastatin induces ER stress-mediated apoptosis through enhancing p53 and Bax translocation to mitochondria
- Aging and Cancer: Activation of p53 by an antitumor antibiotic, ascochlorin, distinct from DNA damaging agents
