NMDA RECEPTOR & FEAR
January 16, 2021
INSULIN & MTOR
February 8, 2021
insulin & aging
- The endocrine regulation of aging by insulin-like signals
- aging and insulin secretion
- Mechanisms of insulin resistance in aging
- Brain insulin and insulin receptors in aging and sporadic Alzheimer’s disease
- Characterization of the insulin resistance of aging.
- insulin resistance with aging
- Glucose intolerance and aging: evidence for tissue insensitivity to insulin
- insulin resistance of muscle protein metabolism in aging
- insulin resistance in aging is related to abdominal obesity
- The insulin paradox: aging, proteotoxicity and neurodegeneration
- insulin and aging
- Decreased cognitive function in aging non-insulin-dependent diabetic patients
- insulin, aging, and the brain: mechanisms and implications
- insulin regulation of heart function in aging fruit flies
- Effect of exercise on insulin action, glucose tolerance, and insulin secretion in aging
- Viral mediated expression of insulin-like growth factor I blocks the aging-related loss of skeletal muscle function
- Removal of visceral fat prevents insulin resistance and glucose intolerance of aging: an adipokine-mediated process?
- Cardiac stem cell and myocyte aging, heart failure, and insulin-like growth factor-1 overexpression
- Physical inactivity and obesity underlie the insulin resistance of aging
- Alcohol intake and insulin levels: the Normative aging Study
- Contribution of visceral fat mass to the insulin resistance of aging
- Caloric restriction reverses hepatic insulin resistance in aging rats by decreasing visceral fat.
- insulin/IGF-like signalling, the central nervous system and aging
- Minireview: role of the growth hormone/insulin-like growth factor system in mammalian aging
- Effects of aging on insulin secretion
- The role of insulin, insulin growth factor, and insulin-degrading enzyme in brain aging and Alzheimer’s disease
- The relationship between insulin-like growth factor-I, adiposity, and aging
- Lipocalin-2 deficiency attenuates insulin resistance associated with aging and obesity
- insulin-like growth factors I and II: aging and bone density in women
- Effect of physical training on the insulin resistance of aging
- Growth hormone, insulin-like growth factor-1 and the aging cardiovascular system
- insulin Resistance and β-Cell Dysfunction in aging: The Importance of Dietary Carbohydrate
- insulin-like growth factor-I, cognition and brain aging
- insulin/IGF-1 paradox of aging: regulation via AKT/IKK/NF-κB signaling
- Effect of aging on insulin receptor, insulin receptor substrate-1, and phosphatidylinositol 3-kinase in liver and muscle of rats
- Impact of reduced insulin‐like growth factor‐1/insulin signaling on aging in mammals: novel findings
- insulin-like growth factor 1 (IGF-1) and aging: controversies and new insights
- Decreased insulin production and increased insulin sensitivity in the klotho mutant mouse, a novel animal model for human aging
- Relationship of dietary saturated fatty acids and body habitus to serum insulin concentrations: the Normative aging Study
- The role of insulin and neurotrophic factor signaling in brain aging and Alzheimer’s Disease
- The aging brain. Changes in the neuronal insulin/insulin receptor signal transduction cascade trigger late-onset sporadic Alzheimer disease (SAD). A mini-review
- Growth hormone and insulin-like growth factor-1 (IGF-1) and their influence on cognitive aging
- Methionine‐deficient diet extends mouse lifespan, slows immune and lens aging, alters glucose, T4, IGF‐I and insulin levels, and increases hepatocyte MIF levels and …
- insulin and glucagon relationships during aging in man
- insulin-like signaling, metabolism, stress resistance and aging in Caenorhabditis elegans
- Effect of aging on response to exercise training in humans: skeletal muscle GLUT-4 and insulin sensitivity
- insulin-like growth factors and aging
- Effects of glucose/insulin perturbations on aging and chronic disorders of aging: the evidence.
- Fetuin-null mice are protected against obesity and insulin resistance associated with aging
- Baseline ventilatory function predicts the development of higher levels of fasting insulin and fasting insulin resistance index: the Normative aging Study
- Uric acid and coronary heart disease risk: evidence for a role of uric acid in the obesity-insulin resistance syndrome: the Normative aging Study
- Human growth hormone and cortisol response to insulin stimulation in aging
- TGF-β and insulin signaling regulate reproductive aging via oocyte and germline quality maintenance
- aging and the growth hormone/insulin like growth factor-I axis
- aging, synaptic dysfunction, and insulin-like growth factor (IGF)-1
- Leucine metabolism in aging humans: effect of insulin and substrate availability
- Influence of insulin, sympathetic nervous system activity, and obesity on blood pressure: the Normative aging Study.
- The key role of growth hormone–insulin–IGF-1 signaling in aging and cancer
- aging impairs insulin-stimulated glucose uptake in rat skeletal muscle via suppressing AMPKα
- Pleiotropic effects of growth hormone and insulin-like growth factor (IGF)-1 on biological aging: inferences from moderate caloric-restricted animals
- Long-lived Klotho mice: new insights into the roles of IGF-1 and insulin in aging
- Decrease in glucose-stimulated insulin secretion with aging is independent of insulin action
- Methionine restriction decreases visceral fat mass and preserves insulin action in aging male Fischer 344 rats independent of energy restriction
- The metabolic clearance of insulin and the feedback inhibition of insulin secretion are altered with aging
- Mitochondrial function, energy expenditure, aging and insulin resistance
- Functional implications of Drosophila insulin-like peptides in metabolism, aging, and dietary restriction
- Change of insulin action with aging in conscious rats determined by euglycemic clamp
- The role of insulin/IGF-like signaling in C. elegans longevity and aging
- Handgrip strength and insulin levels: cross-sectional and prospective associations in the Normative aging Study
- The demography of slow aging in male and female Drosophila mutant for the insulin‐receptor substrate homologue chico
- Activin signaling targeted by insulin/dFOXO regulates aging and muscle proteostasis in Drosophila
- The enteric enhancement of glucose-stimulated insulin release: the role of GIP in aging, obesity, and non-insulin-dependent diabetes mellitus
- Reduced pancreatic B cell compensation to the insulin resistance of aging: impact on proinsulin and insulin levels
- Role of serum insulin-like growth factor I in mammalian brain aging
- Exercise in aging: its important role in mortality, obesity and insulin resistance
- Impairments in availability of insulin to liver in vivo and in binding of insulin to purified hepatic plasma membrane during aging
- Glucocorticoid effects on insulin-and IGF-I-regulated muscle protein metabolism during aging
- Estradiol, insulin-like growth factor-I and brain aging
- Circulating levels of insulin-like growth factor (IGF) binding protein-1 and-3 in aging men: relationships to insulin, glucose, IGF, and dehydroepiandrosterone sulfate …
- Adipocyte insulin resistance: effects of aging, obesity, exercise, and food restriction
- Association of prostate cancer risk with insulin, glucose, and anthropometry in the Baltimore longitudinal study of aging
- insulin binding to cultured human fibroblasts increases with normal and precocious aging
- Low doses of insulin-like growth factor-I induce mitochondrial protection in aging rats
- Growth hormone, insulin-like growth factor-1 and the aging brain
- aging-dependent and-independent modulation of associative learning behavior by insulin/insulin-like growth factor-1 signal in Caenorhabditis elegans
- … serum correlates of aging in the healthy human male: progressive decreases in bioavailable testosterone, dehydroepiandrosterone sulfate, and the ratio of insulin-like …
- The DAF‐2 insulin‐like signaling pathway independently regulates aging and immunity in C. elegans
- Reduction in the chondrocyte response to insulin‐like growth factor 1 in aging and osteoarthritis: studies in a non‐human primate model of naturally occurring disease
- insulin-like growth factor isoforms in skeletal muscle aging, regeneration, and disease
- Relationship between changes in body composition and insulin responsiveness in models of the aging rat
- Effects of aging and sex on plasma insulin-like growth factor I (IGF-I) levels in normal adults
- … of nitrotyrosine in aging and osteoarthritic cartilage: correlation of oxidative damage with the presence of interleukin‐1β and with chondrocyte resistance to insulin …
- aging is associated with decreased suppression of insulin-like growth factor binding protein-1 by insulin
- insulin sensitivity of rat skeletal muscle: effects of starvation and aging.
- … decreases in insulin-like growth factor-I and transforming growth factor-beta in femoral cortical bone from both men and women: implications for bone loss with aging
- Influence of aging on insulin receptor binding and metabolic effects of insulin on human adipose tissue
- SIRT1, neuronal cell survival and the insulin/IGF-1 aging paradox
- … , blood pressure, and insulin resistance through cocoa flavanol consumption in elderly subjects with mild cognitive impairment: the Cocoa, Cognition, and aging …
- Epigenetic oxidative redox shift (EORS) theory of aging unifies the free radical and insulin signaling theories
- insulin/IGF-1 and ROS signaling pathway cross-talk in aging and longevity determination
- Impaired β-cell function in human aging: response to nicotinic acid-induced insulin resistance
- Body size, insulin/IGF signaling and aging in the nematode Caenorhabditis elegans
- insulin/IGF-1 signaling pathway driving aging and cancer as a target for pharmacological intervention
- Effect of diet restriction on glucose metabolism and insulin responsiveness in aging rats
- The nature of insulin secretory defect in aging rats
- insulin regulates aging and oxidative stress in Anopheles stephensi
- Low doses of insulin-like growth factor I improve insulin resistance, lipid metabolism, and oxidative damage in aging rats
- Glucose intolerance, insulin resistance, and pathological features of Alzheimer disease in the Baltimore Longitudinal Study of aging
- aging is associated with resistance to effects of leptin on fat distribution and insulin action
- Differential effects of aging and insulin-like growth factor-1 on synapses in CA1 of rat hippocampus
- Temporal relations between obesity and insulin: longitudinal data from the Normative aging Study
- Growth hormone, insulin and aging: the benefits of endocrine defects
- insulin-like growth factor 1 treatment extends longevity in a mouse model of human premature aging by restoring somatotroph axis function
- Ablation of ghrelin receptor reduces adiposity and improves insulin sensitivity during aging by regulating fat metabolism in white and brown adipose tissues
- Human aging is associated with parallel reductions in insulin and amylin release
- insulin resistance is associated with cognition among HIV-1-infected patients: the Hawaii aging With HIV cohort
- Role of CBP and SATB-1 in aging, dietary restriction, and insulin-like signaling
- insulin exposure and aging theory
- The insulin-like growth factor I generation test: resistance to growth hormone with aging and estrogen replacement therapy
- Dehydroepiandrosterone (DHEA) replacement decreases insulin resistance and lowers inflammatory cytokines in aging humans
- In Vivo insulin-Dependent Glucose Uptake of Specific Tissues Is Decreased during aging of Mature Wistar Rats
- Does aging intensify the insulin resistance of human obesity?
- aging and insulin secretion
- Effects of aging and dietary restriction on tissue protein synthesis: relationship to plasma insulin-like growth factor-1
- insulin-like growth factor-1 in CNS and cerebrovascular aging
- aging-associated insulin resistance predisposes to hypertension and its reversal by exercise: the role of vascular vasorelaxation to insulin
- Oxidative stress contributes to aging by enhancing pancreatic angiogenesis and insulin signaling
- insulin-like growth factors (IGFs): implications for aging
- Alterations in the ultradian oscillations of insulin secretion and plasma glucose in aging
- Increased Susceptibility to insulin Resistance Associated with Abdominal Obesity in aging Rats**
- Glucose and amino acid metabolism in aging man: differential effects of insulin
- Reduced brain insulin-like growth factor I function during aging
- The immune-endocrine loop during aging: role of growth hormone and insulin-like growth factor-I
- … on food intake and plasma CCK, leptin, and insulin concentrations in older and young adults: evidence for increased CCK activity as a cause of the anorexia of aging
- Essential role of protein tyrosine phosphatase 1B in obesity‐induced inflammation and peripheral insulin resistance during aging
- aging and cancer-related loss of insulin-like growth factor 2 imprinting in the mouse and human prostate
- Cardiac-specific overexpression of insulin-like growth factor 1 attenuates aging-associated cardiac diastolic contractile dysfunction and protein damage
- Ability of insulin to modulate hepatic glucose production in aging rats is impaired by fat accumulation
- insulin action in aging man: Evidence for tissue-specific differences at low physiologic insulin levels
- Influence of adiposity in the blunted whole-body protein anabolic response to insulin with aging
- Deficiency of insulin-like growth factor 1 reduces sensitivity to aging-associated cardiomyocyte dysfunction
- Gender differences in hypertrophy, insulin resistance and ischemic injury in the aging type 2 diabetic rat heart
- Myosteatosis and myofibrosis: relationship with aging, inflammation and insulin resistance
- Role of impaired intracellular glucose metabolism in the insulin resistance of aging
- Mitochondrial function and insulin resistance during aging–a mini-review
- Metabolic triad in brain aging: mitochondria, insulin/IGF-1 signalling and JNK signalling
- Metabolic consequences of incorrect insulin administration techniques in aging subjects with diabetes
- Growth hormone/insulin-like growth factor-I axis in aging: a summary of a National Institutes of aging-Sponsored Symposium
- Oxidative aging and insulin receptor signaling
- Articular chondrocytes from aging rats respond poorly to insulin-like growth factor-1: an altered signaling pathway
- Chronic 17β-estradiol treatment improves skeletal muscle insulin signaling pathway components in insulin resistance associated with aging
- Diverse roles of growth hormone and insulin-like growth factor-1 in mammalian aging: progress and controversies
- Growth hormone induces somatostatin and insulin-like growth factor I gene expression in the cerebral hemispheres of aging rats
- insulin Growth Factor‐I Inhibits Apoptosis in Hematopoietic: Progenitor Cells Implications in Thymic aginga
- A possible role for insulin in the altered capability for hepatic enzyme adaptation during aging
- The paradox of neuronal insulin action and resistance in the development of aging-associated diseases
- insulin is differentially related to cognitive decline and atrophy in Alzheimer’s disease and aging
- Impaired ventilatory function and elevated insulin levels in nondiabetic males: the Normative aging Study
- MCH−/− mice are resistant to aging-associated increases in body weight and insulin resistance
- LET‐60 RAS modulates effects of insulin/IGF‐1 signaling on development and aging in Caenorhabditis elegans
- Effect of aging on the sensitivity of growth hormone secretion to insulin-like growth factor-I negative feedback
- insulin resistance and aging: a cause or a protective response?
- Which anthropometric indices of regional adiposity are related to the insulin resistance of aging?
- Altered regulation of insulin secretion in isolated islets of different sizes in aging rats
- Aberrant insulin receptor signaling and amino acid homeostasis as a major cause of oxidative stress in aging
- Regulation of excitation contraction coupling by insulin-like growth factor-1 in aging skeletal muscle.
- Hostility and urine norepinephrine interact to predict insulin resistance: the VA Normative aging Study
- Relationship of serum fibroblast growth factor 21 with abnormal glucose metabolism and insulin resistance: the Baltimore Longitudinal Study of aging
- insulin resistance and fat patterning with aging: relationship to metabolic risk factors for cardiovascular disease
- Appendicular skeletal muscle mass and insulin resistance in an elderly Korean population: the Korean social life, health and aging project-health examination …
- insulin receptor kinase activity in rat adipocytes is decreased during aging
- Diet, not aging, causes skeletal muscle insulin resistance
- Accelerated fat cell aging links oxidative stress and insulin resistance in adipocytes
- Interaction of multiplication stimulating activity/rat insulin-like growth factor II with skeletal muscle satellite cells during aging
- … gene expression of insulin receptor isoforms A and B and insulin receptor substrates 1, 2 and 3 in rat tissues: modulation by aging and differentiation in rat …
- insulin receptors in the brain cortex of aging mice
- aging enhances the insulin resistance in obesity through both receptor and postreceptor alterations
- Training-induced enhancement of insulin action in human skeletal muscle: the influence of aging
- Targeted disruption of inducible nitric oxide synthase protects against aging, S-nitrosation, and insulin resistance in muscle of male mice
- Intranasal insulin improves age-related cognitive deficits and reverses electrophysiological correlates of brain aging
- Changes in insulin receptor kinase with aging in rat skeletal muscle and liver
- Changes in protein, carbohydrate, and fat metabolism with aging: possible role of insulin
- Tissue‐specific insulin signaling in the regulation of metabolism and aging
- Effect of age and caloric restriction on insulin receptor binding and glucose transporter levels in aging rats
- Adipose tissue-derived tumor necrosis factor activity correlates with fat cell size but not insulin action in aging rats
- insulin resistance and depressive symptoms in middle-aged and elderly Chinese: findings from the Nutrition and Health of aging Population in China Study
- The role of the glucose transport system in the postreceptor defect in insulin action associated with human aging
- Metallothionein antagonizes aging‐induced cardiac contractile dysfunction: role of PTP1B, insulin receptor tyrosine phosphorylation and Akt
- Modulation of SIRT1-Foxo1 signaling axis by resveratrol: implications in skeletal muscle aging and insulin resistance
- Caloric restriction and insulin-like growth factors in aging and cancer
- insulin exposure controls the rate of mammalian aging
- aging and insulin resistance in a group of nonobese male volunteers
- The endothelium abridges insulin resistance to premature aging
- Metabolic effects of resveratrol in mammals-a link between improved insulin action and aging
- Effect of gender on insulin resistance associated with aging
- Genetic inactivation of GIP signaling reverses aging-associated insulin resistance through body composition changes
- Impaired mitochondrial fatty acid oxidation and insulin resistance in aging: novel protective role of glutathione
- aging and oxidative stress reduce the response of human articular chondrocytes to insulin‐like growth factor 1 and osteogenic protein 1
- Influence of cardiac‐specific overexpression of insulin‐like growth factor 1 on lifespan and aging‐associated changes in cardiac intracellular Ca2+ homeostasis …
- Effects of aging on dehydroepiandrosterone sulfate in relation to fasting insulin levels and body composition assessed by bioimpedance analysis
- insulin regulation in AhR-null mice: embryonic cardiac enlargement, neonatal macrosomia, and altered insulin regulation and response in pregnant and aging AhR …
- β cell aging markers have heterogeneous distribution and are induced by insulin resistance
- Melatonin can improve insulin resistance and aging-induced pancreas alterations in senescence-accelerated prone male mice (SAMP8)
- Dissociation between metabolic and vascular insulin resistance in aging
- aging and Restriction of Dietary Calories Increases insulin Receptor mRNA, and aging Increases Glucocorticoid Receptor MRNA in the Liver of Female C3B10RF1 …
- Method of treating reduced insulin-like growth factor and bone loss associated with aging
- Regulation of insulin receptor mRNA splicing in rat tissues: effect of fasting, aging, and diabetes
- The ubiquitin ligase CHIP integrates proteostasis and aging by regulation of insulin receptor turnover
- Secretion of insulin during aging
- aging is associated with elevated muscle triglyceride content and increased insulin-stimulated fatty acid uptake
- insulin in aging and cancer: antidiabetic drug Diabenol as geroprotector and anticarcinogen
- Regulation of insulin secretion by glucose during aging
- Effect of aging on insulin secretory function and expression of beta cell function-related genes of islets
- insulin Release in aging: Dynamic Response of Isolated Islets of Langerhans of the Rat to D-Glucose and D-Glycer aldehyde
- Serum insulin‐like growth factor‐1 binding proteins 1 and 2 and mortality in older adults: the Health, aging, and Body Composition Study
- Relationships between insulin-like growth hormone factor-I and estradiol in reproductive aging
- Loss of postprandial insulin sensitization during aging
- aging is associated with increased HbA1c levels, independently of glucose levels and insulin resistance, and also with decreased HbA1c diagnostic specificity
- Longevity pathways (mTOR, SIRT, insulin/IGF-1) as key modulatory targets on aging and neurodegeneration
- Interaction between insulin-like growth factor-1 and atherosclerosis and vascular aging
- The effect of aging on insulin signalling pathway is tissue dependent: central role of adipose tissue in the insulin resistance of aging
- aging does not affect the activation of the myocyte insulin-like growth factor-1 autocrine system after infarction and ventricular failure in Fischer 344 rats
- Effects of epinephrine on insulin secretion and action in humans: interaction with aging
- Restorative effect of intracerebroventricular insulin-like growth factor-I gene therapy on motor performance in aging rats
- Effects of aging on insulin synthesis and secretion. Differential effects on preproinsulin messenger RNA levels, proinsulin biosynthesis, and secretion of newly made …
- Increased expression of type 1 insulin-like growth factor receptor messenger RNA in rat hippocampal formation is associated with aging and behavioral impairment
- insulin/IGF-I and related signaling pathways regulate aging in nondividing cells: from yeast to the mammalian brain
- aging and insulin resistance: just say iNOS
- … and normal prostate aging: differences in types I and II 5 alpha-reductase and steroid hormone receptor messenger ribonucleic acid (mRNA) levels, but not in insulin …
- aging per se increases the susceptibility to free fatty acid–induced insulin resistance
- aging and insulin sensitivity: role of blood pressure and sympathetic nervous system activity
- Stress contributes to the development of central insulin resistance during aging: implications for Alzheimer’s disease
- L-type Ca2+ channel-insulin-like growth factor-1 receptor signaling impairment in aging rat skeletal muscle
- Rats with low brain angiotensinogen do not exhibit insulin resistance during early aging
- insulin-like growth factor-1 stimulation of protein synthesis is attenuated in cerebral cortex of aging rats
- insulin-like growth factor-I receptor densities in human frontal cortex and white matter during aging, in Alzheimer’s disease, and in Huntington’s disease
- Serum levels of insulin‐like growth factor 1 in subjects with osteoarthritis of the knee. Data from the baltimore longitudinal study of aging
- Parental imprinting regulates insulin-like growth factor signaling: a Rosetta Stone for understanding the biology of pluripotent stem cells, aging and …
- From lipodystrophy and insulin resistance to metabolic syndrome: HIV infection, treatment and aging
- aging does not contribute to the decline in insulin action on storage of muscle glycogen in rats
- Glucose intolerance and insulin resistance with aging—studies on insulin receptors and post-receptor events
- aging is associated with myocardial insulin resistance and mitochondrial dysfunction
- … disruption of spermidine/spermine N1‐acetyltransferase gene maintain nearly normal tissue polyamine homeostasis but show signs of insulin resistance upon aging
- Synthesis-secretion coupling of insulin: effect of aging.
- … metabolic alterations in the hippocampus caused by insulin signalling dysfunction and its association with cognitive impairment during aging and Alzheimer’s disease …
- Effect of aging on the expression of peroxisome proliferator-activated receptor γ and the possible relation to insulin resistance
- Heat shock factor-1 intertwines insulin/IGF-1, TGF-β and cGMP signaling to control development and aging
- insulin exposure and unifying aging
- Diminished anabolic signaling response to insulin induced by intramuscular lipid accumulation is associated with inflammation in aging but not obesity
- Dexamethasone-induced insulin resistance and pancreatic adaptive response in aging rats are not modified by oral vanadyl sulfate treatment
- insulin release in aging: studies on adenylate cyclase, phosphodiesterase, and protein kinase in isolated islets of Langerhans of the rat
- Effect of aging on the kinetic characteristics of the insulin receptor autophosphorylation in rat adipocytes
- Short-term estradiol administration in aging ovariectomized rats provides lasting benefits for memory and the hippocampus: a role for insulin-like growth factor-I
- DAF-2/insulin-like signaling in C. elegans modifies effects of dietary restriction and nutrient stress on aging, stress and growth
- insulin‐like growth factor‐I gene therapy increases hippocampal neurogenesis, astrocyte branching and improves spatial memory in female aging rats
- Meal-related increases in vascular reactivity are impaired in older and diabetic adults: insights into roles of aging and insulin in vascular flow
- Dietary (−)-Epigallocatechin-3-gallate supplementation counteracts aging-associated skeletal muscle insulin resistance and fatty liver in senescence-accelerated …
- Serum insulin-like growth factor binding protein (IGFBP)-4 and IGFBP-5 levels in aging and age-associated diseases
- Post-developmental microRNA expression is required for normal physiology, and regulates aging in parallel to insulin/IGF-1 signaling in C. elegans
- Development of insulin resistance during aging: involvement of central processes and role of adipokines
