A chemical or other factor that disturbs a body’s normal processes, causing it to tend toward obesity.
Obesogens are foreign chemical compounds that disrupt normal development and balance of lipid metabolism and lead to obesity.
MECHANISMS OF OBESOGEN ACTION
•Increase of adipocyte number and size
•Altering basal metabolic rate and energy homeostasis
•Changing hypothalamic regulation of appetite and satiety
•Reduced expression of brown adipocyte marker gene
•Impaired glucose uptake and insulin signaling
•Alteration of insulin sensitivity at the organ level
•Alteration of endocrine regulation of adipose tissue development