PANCREATIC LIPASE INHIBITOR
December 8, 2023ANTI OBESOGENIC
December 8, 2023
- Of mice and men: The physiological role of adipose triglyceride lipase (ATGL)
- Hints on ATGL implications in cancer: beyond bioenergetic clues
- Perilipin controls lipolysis by regulating the interactions of AB-hydrolase containing 5 (Abhd5) and adipose triglyceride lipase (Atgl)
- Recent advances on the role of ATGL in cancer
- Unique regulation of adipose triglyceride lipase (ATGL) by perilipin 5, a lipid droplet-associated protein
- ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1
- ATGL has a key role in lipid droplet/adiposome degradation in mammalian cells
- The adipose tissue triglyceride lipase ATGL/PNPLA2 is downregulated by insulin and TNF-α in 3T3-L1 adipocytes and is a target for transactivation by PPARγ
- ATGL promotes autophagy/lipophagy via SIRT1 to control hepatic lipid droplet catabolism
- FoxO1 controls insulin-dependent adipose triglyceride lipase (ATGL) expression and lipolysis in adipocytes
- Desnutrin/ATGL is regulated by AMPK and is required for a brown adipose phenotype
- Cold-induced thermogenesis depends on ATGL-mediated lipolysis in cardiac muscle, but not brown adipose tissue
- ATGL is a biosynthetic enzyme for fatty acid esters of hydroxy fatty acids
- Long non-coding RNA NEAT1-modulated abnormal lipolysis via ATGL drives hepatocellular carcinoma proliferation
- Anti-angiogenic pigment epithelium-derived factor regulates hepatocyte triglyceride content through adipose triglyceride lipase (ATGL)
- Differential control of ATGL-mediated lipid droplet degradation by CGI-58 and G0S2
- ATGL-catalyzed lipolysis regulates SIRT1 to control PGC-1α/PPAR-α signaling
- Dysregulation of lipolysis and lipid metabolism in visceral and subcutaneous adipocytes by high-fat diet: role of ATGL, HSL, and AMPK
- AMPK phosphorylates desnutrin/ATGL and hormone-sensitive lipase to regulate lipolysis and fatty acid oxidation within adipose tissue
- Insulin inhibits lipolysis in adipocytes via the evolutionarily conserved mTORC1-Egr1-ATGL-mediated pathway
- SIRT1 controls lipolysis in adipocytes via FOXO1-mediated expression of ATGL
- Spatial regulation of UBXD8 and p97/VCP controls ATGL-mediated lipid droplet turnover
- Prolonged AICAR-induced AMP-kinase activation promotes energy dissipation in white adipocytes: novel mechanisms integrating HSL and ATGL
- Skeletal muscle PLIN proteins, ATGL and CGI-58, interactions at rest and following stimulated contraction
- Myocardial ATGL overexpression decreases the reliance on fatty acid oxidation and protects against pressure overload-induced cardiac dysfunction
- Impact of reduced ATGL-mediated adipocyte lipolysis on obesity-associated insulin resistance and inflammation in male mice
- Fat-specific protein 27 (FSP27) interacts with adipose triglyceride lipase (ATGL) to regulate lipolysis and insulin sensitivity in human adipocytes
- The minimal domain of adipose triglyceride lipase (ATGL) ranges until leucine 254 and can be activated and inhibited by CGI-58 and G0S2, respectively
- LncRNA SRA promotes hepatic steatosis through repressing the expression of adipose triglyceride lipase (ATGL)
- Inhibition of adipose triglyceride lipase (ATGL) by the putative tumor suppressor G0S2 or a small molecule inhibitor attenuates the growth of cancer cells
- Adipose triglyceride lipase (ATGL) and hormone-sensitive lipase (HSL) deficiencies affect expression of lipolytic activities in mouse adipose tissues
- Adipose triglyceride lipase (ATGL) expression in human skeletal muscle is type I (oxidative) fiber specific
- Fasting, but not exercise, increases adipose triglyceride lipase (ATGL) protein and reduces G (0)/G (1) switch gene 2 (G0S2) protein and mRNA content in human …
- Effect of endurance training intensity (low, moderate and high) on the expression of skeletal muscle ATGL protein and serum levels of insulin and glucose in …
- … mutations affecting the carboxyl terminus of perilipin increase lipolysis by failing to sequester the adipose triglyceride lipase (ATGL) coactivator AB-hydrolase …
- Lipid Droplet Protein LID-1 Mediates ATGL-1-Dependent Lipolysis during Fasting in Caenorhabditis elegans
- The ATGL Gene Is Associated With Free Fatty Acids, Triglycerides, and Type 2 Diabetes
- Desnutrin/ATGL activates PPARδ to promote mitochondrial function for insulin secretion in islet β cells
- Elevated ATGL in colon cancer cells and cancer stem cells promotes metabolic and tumorigenic reprogramming reinforced by obesity
- Interaction between the triglyceride lipase ATGL and the Arf1 activator GBF1
- PGC-1/spargel counteracts high-fat-diet-induced obesity and cardiac lipotoxicity downstream of TOR and brummer ATGL lipase
- Distinct mechanisms regulate ATGL-mediated adipocyte lipolysis by lipid droplet coat proteins
- Hypophagia and metabolic adaptations in mice with defective ATGL-mediated lipolysis cause resistance to HFD-induced obesity
- A beta cell ATGL-lipolysis/adipose tissue axis controls energy homeostasis and body weight via insulin secretion in mice
- Forcing ATGL expression in hepatocarcinoma cells imposes glycolytic rewiring through PPAR-α/p300-mediated acetylation of p53
- 17β‐estradiol supplementation attenuates ovariectomy‐induced increases in ATGL signaling and reduced perilipin expression in visceral adipose tissue
- Fenofibrate lowers lipid accumulation in myotubes by modulating the PPARα/AMPK/FoxO1/ATGL pathway
- Developmental, hormonal, and nutritional regulation of porcine adipose triglyceride lipase (ATGL)
- The ATGL lipase cooperates with ABHD5 to mobilize lipids for hepatitis C virus assembly
- ATGL-mediated triglyceride turnover and the regulation of mitochondrial capacity in skeletal muscle
- Hepatic ATGL knockdown uncouples glucose intolerance from liver TAG accumulation
- Contribution of novel ATGL missense mutations to the clinical phenotype of NLSD-M: a strikingly low amount of lipase activity may preserve cardiac function
- The novel non‐steroidal MR antagonist finerenone improves metabolic parameters in high‐fat diet‐fed mice and activates brown adipose tissue via AMPK‐ATGL …
- Regulation of hepatic triacylglycerol metabolism by CGI-58 does not require ATGL co-activation
- Regulation of ATGL expression mediated by leptin in vitro in porcine adipocyte lipolysis
- Inhibition of ATGL in adipose tissue ameliorates isoproterenol-induced cardiac remodeling by reducing adipose tissue inflammation
- Coordinated transcriptional control of adipocyte triglyceride lipase (Atgl) by transcription factors Sp1 and peroxisome proliferator–activated receptor γ (PPARγ) …
- Higher levels of ATGL are associated with exercise-induced enhancement of lipolysis in rat epididymal adipocytes
- Hepatic ATGL mediates PPAR-α signaling and fatty acid channeling through an L-FABP independent mechanism
- Adipose triglyceride lipase (ATGL) expression is associated with adiposity and tumor stromal proliferation in patients with pancreatic ductal adenocarcinoma
- ATGL/CGI-58-dependent hydrolysis of a lipid storage pool in murine enterocytes
- PPARa‐ATGL pathway improves muscle mitochondrial metabolism: implication in aging
- Ubiquitin ligase COP1 controls hepatic fat metabolism by targeting ATGL for degradation
- Chronic TNFα and cAMP pre-treatment of human adipocytes alter HSL, ATGL and perilipin to regulate basal and stimulated lipolysis
- ATGL and DGAT1 are involved in the turnover of newly synthesized triacylglycerols in hepatic stellate cells [S]
- Adipose‐specific ATGL ablation reduces burn injury‐induced metabolic derangements in mice
- ATGL-1 mediates the effect of dietary restriction and the insulin/IGF-1 signaling pathway on longevity in C. elegans
- The hepatitis C virus core protein inhibits adipose triglyceride lipase (ATGL)-mediated lipid mobilization and enhances the ATGL interaction with comparative …
- Long non-coding RNA NEAT1 facilitates the growth, migration, and invasion of ovarian cancer cells via the let-7 g/MEST/ATGL axis
- Atgl deficiency induces podocyte apoptosis and leads to glomerular filtration barrier damage
- Adipose tissue ATGL modifies the cardiac lipidome in pressure-overload-induced left ventricular failure
- PEDF and PEDF-derived peptide 44mer stimulate cardiac triglyceride degradation via ATGL
- Fat-reducing effects of dehydroepiandrosterone involve upregulation of ATGL and HSL expression, and stimulation of lipolysis in adipose tissue
- ATGL-dependent white adipose tissue lipolysis controls hepatocyte PPARα activity
- Restoration of lipid homeostasis between TG and PE by the LXRα-ATGL/EPT1 axis ameliorates hepatosteatosis
- Coordination among lipid droplets, peroxisomes, and mitochondria regulates energy expenditure through the CIDE-ATGL-PPARα pathway in adipocytes
- Targeting ATGL to rescue BSCL2 lipodystrophy and its associated cardiomyopathy
- Cytokine-mediated STAT3 transcription supports ATGL/CGI-58-dependent adipocyte lipolysis in cancer cachexia
- ATGL and CGI-58 are lipid droplet proteins of the hepatic stellate cell line HSC-T6
- The vesicular transporter STX11 governs ATGL-mediated hepatic lipolysis and lipophagy
- Burkholderia pseudomallei interferes with host lipid metabolism via NR1D2-mediated PNPLA2/ATGL suppression to block autophagy-dependent inhibition of …
- Molecular cloning, expression profiling of adipose triglyceride lipase (ATGL) and forkhead box O1 (FoxO1), and effects of dietary carbohydrate level on their …
- Triptolide enhances lipolysis of adipocytes by enhancing ATGL transcription via upregulation of p53
- ATGL activity regulates GLUT1-mediated glucose uptake and lactate production via TXNIP stability in adipocytes
- PNPLA3 (I148M) inhibits lipolysis by perilipin-5-dependent competition with ATGL
- Localized increases in CEPT1 and ATGL elevate plasmalogen phosphatidylcholines in HDLs contributing to atheroprotective lipid profiles in hyperglycemic …
- ERα regulates lipid metabolism in bone through ATGL and perilipin
- Distinct roles for α-β hydrolase domain 5 (ABHD5/CGI-58) and adipose triglyceride lipase (ATGL/PNPLA2) in lipid metabolism and signaling
- ATGL deficiency aggravates pressure overload-triggered myocardial hypertrophic remodeling associated with the proteasome-PTEN-mTOR-autophagy …
- … salt promote the muscle triglyceride hydrolysis during dry-salting by inducing the phosphorylation of adipose tissue triglyceride lipase (ATGL) and hormone-sensitive …
- Resting skeletal muscle PNPLA2 (ATGL) and CPT1B are associated with peak fat oxidation rates in men and women but do not explain observed sex differences
- Comparative proteomics reveals abnormal binding of ATGL and dysferlin on lipid droplets from pressure overload-induced dysfunctional rat hearts
- Palmitate induces fat accumulation via repressing FoxO1-mediated ATGL-dependent lipolysis in HepG2 hepatocytes
- Inhibition of age-related cytokines production by ATGL: a mechanism linked to the anti-inflammatory effect of resveratrol
- Enterocyte-specific ATGL overexpression affects intestinal and systemic cholesterol homeostasis
- Increases in skeletal muscle ATGL and its inhibitor G0S2 following 8 weeks of endurance training in metabolically different rat skeletal muscles
- Long noncoding RNA LTCONS_00091578 associated with adipose triglyceride lipase (ATGL) regulates hepatic lipolysis in rainbow trout
- Reduced ATGL-mediated lipolysis attenuates β-adrenergic-induced AMPK signaling, but not the induction of PKA-targeted genes, in adipocytes and adipose tissue
- Oroxylin A regulates the turnover of lipid droplet via downregulating adipose triglyceride lipase (ATGL) in hepatic stellate cells
- Depletion of Rab32 decreases intracellular lipid accumulation and induces lipolysis through enhancing ATGL expression in hepatocytes
- BETi enhance ATGL expression and its lipase activity to exert their antitumoral effects in triple-negative breast cancer (TNBC) cells
- Residues of the minimal sequence of G0S2 collectively contribute to ATGL inhibition while C-and N-terminal extensions promote binding to ATGL
- Piromelatine decreases triglyceride accumulation in insulin resistant 3T3-L1 adipocytes: role of ATGL and HSL
- Baicalin ameliorates alcohol-induced hepatic steatosis by suppressing SREBP1c elicited PNPLA3 competitive binding to ATGL
- Adipose triglyceride lipase (ATGL) clone, expression pattern, and regulation by different lipid sources and lipid levels in large yellow croaker (Pseudosciaena crocea …
- OSBPL2 Is Required for the Binding of COPB1 to ATGL and the Regulation of Lipid Droplet Lipolysis
- 4E-BPs control fat storage by regulating the expression of Egr1 and ATGL
- … of salt on intramuscular neutral lipid hydrolysis during dry-salting process of porcine (biceps femoris) muscles by inducing phosphorylation of ATGL, HSL and their …
- Atgl gene deletion predisposes to proximal tubule damage by impairing the fatty acid metabolism
- Regulation of G0/G1 switch gene 2 (G0S2) protein ubiquitination and stability by triglyceride accumulation and ATGL interaction
- Mild mitochondrial uncoupling induces HSL/ATGL‐independent lipolysis relying on a form of autophagy in 3T3‐L1 adipocytes
- ATGL promotes the proliferation of hepatocellular carcinoma cells via the p‐AKT signaling pathway
- Lipid droplet-associated hydrolase promotes lipid droplet fusion and enhances ATGL degradation and triglyceride accumulation
- Loss of ephrin B2 receptor (EPHB2) sets lipid rheostat by regulating proteins DGAT1 and ATGL inducing lipid droplet storage in prostate cancer cells
- Metformin regulates hepatic lipid metabolism through activating AMP-activated protein kinase and inducing ATGL in laying hens
- Hedgehog signaling promotes lipolysis in adipose tissue through directly regulating Bmm/ATGL lipase
- ATGL and HSL are not coordinately regulated in response to fuel partitioning in fasted rats
- … of a sensitive collection heuristic for very large protein families: evolutionary relationship between adipose triglyceride lipase (ATGL) and classic mammalian …
- Changes of hormone-sensitive lipase (HSL), adipose tissue triglyceride lipase (ATGL) and free fatty acids in subcutaneous adipose tissues throughout the ripening …
- Structure–activity studies in the development of a hydrazone based inhibitor of adipose-triglyceride lipase (ATGL)
- Adipose triglyceride lipase (Atgl) mediates the antibiotic jinggangmycin-stimulated reproduction in the brown planthopper, Nilaparvata lugens Stål
- PEDF promotes nuclear degradation of ATGL through COP1
- Aerobic exercise promotes the expression of ATGL and attenuates inflammation to improve hepatic steatosis via lncRNA SRA
- Circular RNA cMras Suppresses the Progression of Lung Adenocarcinoma Through ABHD5/ATGL Axis Using NF-κB Signaling Pathway
- The hsa-miR-214-3p/ATGL axis regulates aberrant lipolysis to promote acute myeloid leukemia progression via PPARα in vitro
- PKA/ATGL signaling pathway is involved in ER stress-mediated lipolysis in adipocytes of grass carp (Ctenopharyngodon idella)
- Maternal Prenatal Folic Acid Supplementation Programs Offspring Lipid Metabolism by Aberrant DNA Methylation in Hepatic ATGL and Adipose LPL in Rats
- The impact of genetic stress by ATGL deficiency on the lipidome of lipid droplets from murine hepatocytes
- cDNA cloning, characterization, and variation analysis of chicken adipose triglyceride lipase (ATGL) gene
- HSL and ATGL: The movers and shakers of muscle lipolysis
- N-end Rule–Mediated Proteasomal Degradation of ATGL Promotes Lipid Storage
- Associations of ATGL gene polymorphisms with chicken growth and fat traits
- Molecular cloning of adipose triglyceride lipase (ATGL) gene from blunt snout bream and its expression after LPS-induced TNF-α factor
- Genetic control of ATGL-mediated lipolysis modulates adipose triglyceride stores in leptin-deficient mice
- The reduction of lipid-sourced energy production caused by ATGL inhibition cannot be compensated by activation of HSL, autophagy, and utilization of other nutrients …
- ATGL-mediated lipophagy balances cholesterol-induced inflammation in pathogen infected Apostichopus japonicus coelomocytes
- Camptothecin activates SIRT1 to promote lipid catabolism through AMPK/FoxO1/ATGL pathway in C2C12 myogenic cells
- Identification and characterization of adipose triglyceride lipase (ATGL) gene in birds
- Nicotinamide mononucleotide induces lipolysis by regulating ATGL expression via the SIRT1-AMPK axis in adipocytes
- … (G0S2) expression in male Sprague-Dawley rat skeletal muscle compared to relative content of adipose triglyceride lipase (ATGL) and comparitive gene …
- Overexpression of ATGL impairs lipid droplet accumulation by accelerating lipolysis in goat mammary epithelial cells
- Effect of global ATGL knockout on murine fasting glucose kinetics
- Structure-activity relationship studies for the development of inhibitors of murine adipose triglyceride lipase (ATGL)
- Effects of dietary corn peptide and exercise on hepatic ATGL and TNF-α in obese rats
- The crucial role of ATGL for energy supply of muscles 1
- cDNA cloning, expression and regulation analysis of goose adipose triglyceride lipase (ATGL) gene
- Rare ATGL haplotypes are associated with increased plasma triglyceride concentrations in the Greenland Inuit
- Elevated ATGL in colon cancer cells and cancer stem cells promotes metabolic and tumorigenic reprogramming reinforced by obesity
- Lipase tug of war: PNPLA3 sequesters ABHD5 from ATGL
- Cloning and tissue expression analysis of adipose triglyceride lipase gene (ATGL) of Xinong Saanen dairy goats.
- ATGL gene expression and the influence of n-3 HUFAs in grass carp (Ctenopharyngodon idellus).
- Lutein prevents the excessive fat deposition in liver and abdominal tissues by activating SIRT1 and up-regulating ATGL and HSL in high fat diet rats (FS06-01-19)
- Unmasking Crucial Residues in Adipose Triglyceride Lipase (ATGL) for Co-Activation with Comparative Gene Identification-58 (CGI-58)
- ATGL deficiency-induced triglyceride deposit cardiomyovasculopathy requiring heart transplant: a 5-year follow-up
- Neonatal exposure of bisphenol A led to increased lipolysis of visceral adipose tissue in adult rats with DNA hypomethylation of Atgl being one of the possible …
- The critical role of BTRC in hepatic steatosis as an ATGL E3 ligase
- The effect of interval and continuous training on the content of perilipin 1, ATGL and CGI-58 in visceral adipose tissue of obese male rats
- ATGL is differentially required for adipocyte FABP4 secretion in vivo and ex vivo
- 1336-P: FoxO1-ATGL-Sirt1-FoxO1 Feed Forward Signaling Mediates Effects on Hepatic Gene Expression and Glucose Homeostasis in LIRKO Mice
- Role of Elevated Adipose Triglyceride Lipase (ATGL) in Lipid Droplet (LDs) Utilization to Promote Colon Cancer Growth Reinforced by Obesity
- Effects of Complanatus flavonoids on triglyceride, DGAT2 and ATGL of hepatic in hyperlipidemia rats.
- The Role of ATGL-1 in CeTOR Regulated Longevity in C. Elegans
- Silencing ATGL gene expression inhibits the proliferation, migration and invasion of hepatocellular carcinoma cells
- Adipose Triglyceride Lipase (ATGL) Has a Role in Muscle Lipid Oxidation and Is Upregulated by Pioglitazone in Adipose Tissue of Humans.
- Association of dietary and plasma fatty acids with adipose triglyceride lipase (ATGL) and hormone-sensitive lipase (HSL) gene expression in human adipose tissues
- Hepatic ATGL manipulation regulates lipid metabolism through altered autophagy
- Proteomic analysis of proteins regulate ATGL lipolytic activity in skeletal muscle
- Mechanism of ATGL mediated changes in hepatic energy metabolism: role of LFABP
- Hepatic Adipose Triglyceride Lipase (ATGL) regulates glucose tolerance but not hepatic insulin signaling
- The Correlation Analysis of CHGA and ATGL in Patients of Type 2 Diabetes Mellitus with Nonalcoholic Fatty Liver Disease
- Relationship between serum ATGL and inflammatory factors in patients with coronary heart disease
- ATGL‐catalyzed lipolysis regulates SIRT1 to control PGC‐1a/PPAR‐a signaling
- Cyclin D1 regulates adipose triglyceride lipase (ATGL) to influence hepatic lipid droplet metabolism and cell proliferation
- Development of small-molecule inhibitors targeting adipose triglyceride lipase (ATGL)
- ATGL Is Not Required for Oleate Protection from Lipotoxicity in NIH3T3 Cells
- 289 Cardiomyocyte-specific ATGL over-expression prevents doxorubicin-induced cardiac dysfunction in mice
- Regulation of ATGL-mediated lipolysis by FSP2/CIDEC in human adipocytes
- ATGL-1 and longevity in C. elegans
- Adipose triglyceride lipase (ATGL) deletion from adipocytes, but not skeletal myocytes, impairs acute exercise performance in mice 2
- Datset for” Resting skeletal muscle ATGL and CPT1B are associated with peak fat oxidation rates in men and women but do not explain observed sex differences”
- Hepatic ATGL Mediates Fatty Acid Oxidation and PPAR-α Signaling Through an LFABP-Independent Mechanism
- Adipocyte-specific Pharmacological Inhibition of Adipose Triglyceride Lipase (ATGL) Ameliorates Cardiac Fibrosis in Heart Failure
- Construction and identification of porcine adipose triglyceride lipase (ATGL) siRNA expression vector.
- Two novel missense mutations in bovine ATGL gene and their association with economic traits in Qinchuan cattle
- Quantification of Glucose Turnover and Cori Cycling in ATGL-knockout Mice by [U- 13C6]Glucose Infusion and LC-MS/MS Analysis of Glucose 13C-Isotopomers
- GW26-e1079 Comparative Proteomics Reveals Abnormal Binding of ATGL and Dysferlin on Dysfunctional Cardiac Lipid Droplets
- The role of Desnutrin/ATGL in promoting a brown‐adipose‐phenotype and regulation via AMPK
- Effect of endurance training intensity [low, moderate and high] on the expression of skeletal muscle ATGL protein and serum levels of insulin and glucose in male …
- The phosphorylation of serine 492 of perilipin A facilitates ATGL-mediated lipolysis by CGI-58 independent mechanisms
- The impact of ATGL deficiency on DHA biosynthesis
- … in Nutrition. The abstract “Lutein Prevents the Excessive Fat Deposition in Liver and Abdominal Tissues by Activating SIRT1 and Up-regulating ATGL and HSL in High …
- Adipose TriGlyceride Lipase (ATGL) and Hormone-Sensitive Lipase (HSL) protein expression is decreased in the obese insulin resistant state
- G0S2 impairs ATGL activity and cell cycle progression in murine liver
- AMPK Regulates Lipolysis by Phosphorylation of Desnutrin/ATGL at Serine406
