Repair of iron-induced DNA oxidation by the flavonoid myricetin in primary rat hepatocyte cultures Dietary flavonoids protect human colonocyte DNA from oxidative attack in vitro Protective effect of rutin, a flavonol glycoside, on the carcinogen-induced DNA damage and repair enzymes in rats The effect of dietary flavonoids on DNA damage (strand breaks and oxidised pyrimdines) and growth in human cells Quercetin and myricetin protect against hydrogen peroxide-induced DNA damage (strand breaks and oxidised pyrimidines) in human lymphocytes Protection from UV-B-induced DNA damage by flavonoids Basic mechanisms of antioxidant activity Hibiscus protocatechuic acid protects against oxidative damage induced by tert-butylhydroperoxide in rat primary hepatocytes Differential visualization of transparent testa mutants in Arabidopsis thaliana Cancer‐Protective Factors in Fruits and Vegetables: Biochemical and Biological Background. The biochemistry of green tea polyphenols and their potential application in human skin cancer Severe sensitivity to ultraviolet radiation in an Arabidopsis mutant deficient in flavonoid accumulation Bioactive phytochemicals with emphasis on dietary practices Higher plants and UV-B radiation: balancing damage, repair and acclimation Kaempferol-induced nuclear DNA damage and lipid peroxidation Oxygen and nitrogen are pro-carcinogens. Damage to DNA by reactive oxygen, chlorine and nitrogen species: measurement, mechanism and the effects of nutrition Quercetin prevents DNA single strand breakage and cytotoxicity caused by tert-butylhydroperoxide: free radical scavenging versus iron chelating mechanism Antioxidant and pro-oxidant actions of flavonoids : effects on DNA damage induced by nitric oxide, peroxynitrite and nitroxyl anion Effect of emodin on cooked-food mutagen activation DNA repair in higher plants Genotoxic effects of crude juices from Brassica vegetables and juices and extracts from phytopharmaceutical preparations and spices of cruciferous plants origin in … Biological effects of myricetin Arabidopsis mutants lacking phenolic sunscreens exhibit enhanced ultraviolet-B injury and oxidative damage flavonoids modulate comet assay responses to food mutagens in human lymphocytes and sperm Stimulation of bioactive flavonoid production in suspension and bioreactor-based cell cultures A review of the genetic effects of naturally occurring flavonoids , anthraquinones and related compounds Antioxidant defence mechanisms: from the beginning to the end (of the beginning) Protection by the flavonoids myricetin, quercetin, and rutin against hydrogen peroxide-induced DNA damage in Caco-2 and Hep G2 cells Mechanistic considerations in chemopreventive drug development Mechanisms of inhibitors of mutagenesis and carcinogenesis Commentary oxidative stress, nutrition and health. Experimental strategies for optimization of nutritional antioxidant intake in humans Modulating effects of flavonoids on food mutagens in human blood and sperm samples in the comet assay Plant‐derived products as antimutagens Inhibition of the induction of cancer by antioxidants Antimutagenesis and antioxidation by phenolic compounds Generation of hydrogen peroxide by “antioxidant” beverages and the effect of milk addition. Is cocoa the best beverage? Dietary modifiers of carcinogenesis. Can oxidative DNA damage be used as a biomarker of cancer risk in humans? Problems, resolutions and preliminary results from nutritional supplementation studies Natural-product inhibitors of human DNA ligase I Inhibition of 7, 12-dimethylbenz (a) anthracene-and N-nitrosomethylurea-induced rat mammary cancer by dietary flavonol quercetin Protective effects of dried flower extracts of Hibiscus sabdariffa L. against oxidative stress in rat primary hepatocytes
Studies on the effect of nicotinic acid on catecholamine stimulated lipolysis in adipose tissue in vitro. Hormone-stimulated lipolysis in isolated fat cells from “young” and “old” rats Impairment of cold-stimulated lipolysis by acute hypoxia Bimodal effect of insulin on hormone-stimulated lipolysis: relation to intracellular 3′, 5′-cyclic adenylic acid and free fatty acid levels lipolysis in chicken adipose tissue in vitro Effects of electrolytes on epinephrine stimulated lipolysis in adipose tissue in vitro Effect of vitamin D2 on hormone-stimulated lipolysis in vitro Metabolic inhibitors and catecholamine-stimulated lipolysis Role of Ca2+ in adrenocorticotropic hormone-stimulated lipolysis in the perifused fat cell system The inhibition of norepinephrine-stimulated lipolysis by acute hypoxia Digitoxin and prostaglandin ei as inhibitors of catecholamine-stimulated lipolysis and their interaction with Ca2+ in the process Endotoxin-induced alterations in isolated fat cells: Effect on norepinephrine-stimulated lipolysis and cyclic 3′, 5′-adenosine monophosphate accumulation Effect of cell size on lipolysis and antilipolytic action of insulin in human fat cells Effect of antimycin A on hormone-stimulated lipolysis in vitro Dependence of hormone-stimulated lipolysis on energy metabolism INFLUENCE OF THE HYPOTHYROID STATE ON lipolysis IN HUMAN ADIPOSE TISSUE IN VITRO: Hypothyroid State and lipolysis Effect of Nicotinic Acid on ACTH and Noradrenaline stimulated lipolysis in the Rabbit. II. In Vitro Studies Including Comparison with Prostaglandin E1 Hormonal regulation of lipolysis and phosphorylase activity in human fat cells The effect of local anaesthetic agents on lipolysis by human adipose tissue lipolysis of human adipose tissue cells: influence of donor factors The effect of dihydroergotamine on ACTH-stimulated lipolysis in rat adipocytes An abnormality of adrenaline, phentolamine stimulated lipolysis in adipose tissue from obese, maturity-onset diabetics The action of local anaesthetics on lipolysis and on adenosine 3′: 5′-cyclic monophosphate content in isolated rat fat-cells Ethanol inhibition of serum stimulated lipolysis in isolated fat cells of the rat lipolysis of genetically obese and/or hyperglycemic mice with reference to insulin response of adipose tissue Growth and lipolysis of rat adipose tissue: effect of age, body weight, and food intake Studies on lipolysis in human adipose cells The effect of human placental lactogen on adipose tissue lipolysis Diethyl chelidonate, a specific inhibitor of hormone-stimulated lipolysis lipolysis by human adipose tissue: The role of cyclic 3′, 5′-adenosine monophosphate and adrenergic receptor sites Effect of weight and cell size on hormone-induced lipolysis in New Zealand obese mice and American obese hyperglycemic micce lipolysis in vitro in adipose tissue from embryonic and growing chicks Effect of nicotinic acid on ACTH and noradrenaline stimulated lipolysis in the rabbit. 1. In vivo studies. Transport-inducing antibiotics (Gramicidin and Valinomycin) as inhibitors of catecholamine-stimulated lipolysis in vitro Stimulation of lipolysis and calcium accumulation by parathyroid hormone in rat adipose tissue in vitro after adrenalectomy and administration of high doses of … Inhibition of lipolysis in bovine adipose tissue by butyrate and β-hydroxybutyrate The effect of local anaesthetics on lipolysis in fat-cells An in vitro effect of triiodothyronine on lipolysis, cyclic AMP-C14 accumulation and oxygen consumption in isolated fat cells lipolysis and lipogenesis from glucose in human fat cells of
Metabolic reprogramming: the emerging concept and associated therapeutic strategies HIF1α and Metabolic reprogramming in inflammation Lipid Metabolic reprogramming in cancer cells Metabolic reprogramming: a cancer hallmark even warburg did not anticipate Metabolic reprogramming of the tumor miRNAs link Metabolic reprogramming to oncogenesis Metabolic reprogramming of immune cells in cancer progression The biology of cancer: Metabolic reprogramming fuels cell growth and proliferation Metabolic reprogramming and Metabolic dependency in T cells Metabolic reprogramming in glioma Oxygen availability and Metabolic reprogramming in cancer Lipid Metabolic reprogramming in hepatocellular carcinoma Metabolic reprogramming during neuronal differentiation Metabolic reprogramming of stem cell epigenetics The transcription factor Myc controls Metabolic reprogramming upon T lymphocyte activation Anti-inflammatory effect of IL-10 mediated by Metabolic reprogramming of macrophages Metabolic reprogramming, caloric restriction and aging Linking Metabolic reprogramming to therapy resistance in cancer Oncogenic regulation of tumor Metabolic reprogramming Metabolic reprogramming and epithelial‐to‐mesenchymal transition in cancer Regulation of immune cell functions by Metabolic reprogramming Oxidative stress, tumor microenvironment, and Metabolic reprogramming: a diabolic liaison Metabolic reprogramming in macrophages and dendritic cells in innate immunity Metabolic reprogramming of the tumour microenvironment Cancer metabolism: key players in Metabolic reprogramming Contribution of Metabolic reprogramming to macrophage plasticity and function Reciprocal Metabolic reprogramming through lactate shuttle coordinately influences tumor-stroma interplay Metabolic reprogramming by class I and II histone deacetylases Metabolic reprogramming in cancer: unraveling the role of glutamine in tumorigenesis Dysregulated Metabolic enzymes and Metabolic reprogramming in cancer cells Control of nutrient stress-induced Metabolic reprogramming by PKCζ in tumorigenesis Metabolic reprogramming by viruses in the sunlit and dark ocean Energy Metabolic reprogramming in the hypertrophied and early stage failing heart: a multisystems approach Viral Metabolic reprogramming in marine ecosystems Metabolic reprogramming in brain tumors Clinical significance of T cell Metabolic reprogramming in cancer Metabolic reprogramming of cancer-associated fibroblasts by IDH3α downregulation Metabolic reprogramming of natural killer cells in obesity limits antitumor responses mTORC2 in the center of cancer Metabolic reprogramming Metabolic reprogramming of periwinkle plant culture Metabolic reprogramming in clear cell renal cell carcinoma Influence of the tumor microenvironment on cancer cells Metabolic reprogramming Cancer Metabolic reprogramming: importance, main features, and potentials for precise targeted anti-cancer therapies The autophagy conundrum in cancer: influence of tumorigenic Metabolic reprogramming Analysis of hypoxia-induced Metabolic reprogramming Molecular drivers of cellular Metabolic reprogramming in melanoma The role of YAP/TAZ activity in cancer Metabolic reprogramming Global Metabolic reprogramming of colorectal cancer occurs at adenoma stage and is induced by MYC Metabolic reprogramming: a hallmark of viral oncogenesis Metabolic reprogramming and tolerance during sepsis-induced AKI Metabolic reprogramming by the PI3K-Akt-mTOR pathway in cancer PDK1-dependent Metabolic reprogramming dictates metastatic potential in breast cancer Metabolic reprogramming during TGFβ1-induced epithelial-to-mesenchymal transition Nrf2 redirects glucose and glutamine into anabolic pathways in Metabolic reprogramming Metabolic reprogramming supports IFN-γ production by CD56bright NK cells Genetically-defined Metabolic reprogramming in cancer Cell-autonomous Metabolic reprogramming in hypoxia A role for the Krebs cycle intermediate citrate in Metabolic reprogramming in innate immunity and inflammation Targeting Metabolic reprogramming in KRAS-driven cancers Targeting Metabolic reprogramming by influenza infection for therapeutic intervention ADHFE1 is a
Understanding Adipocyte differentiation Adipocyte differentiation from the inside out Control of Adipocyte differentiation Adipocyte differentiation and gene expression Molecular regulation of Adipocyte differentiation E2Fs regulate Adipocyte differentiation The roles of PPARs in Adipocyte differentiation Failure of Adipocyte differentiation causes type II diabetes mellitus? The role of MAPKs in Adipocyte differentiation and obesity Transcriptional regulation of gene expression during Adipocyte differentiation Role of intracellular calcium in human Adipocyte differentiation The role of C/EBP genes in Adipocyte differentiation Adipocyte differentiation: from fibroblast to endocrine cell Molecular mechanisms of Adipocyte differentiation Adipocyte differentiation and leptin expression Regulation of Adipocyte differentiation Hormonal signaling and transcriptional control of Adipocyte differentiation Adipocyte differentiation of multipotent cells established from human adipose tissue Analysis of cell cycle arrest in Adipocyte differentiation Obesity associated with a mutation in a genetic regulator of Adipocyte differentiation Enhancement of Adipocyte differentiation by an insulin-sensitizing agent. Insights into the transcriptional control of Adipocyte differentiation MicroRNA and 3T3-L1 pre-Adipocyte differentiation Role of preAdipocyte factor I in Adipocyte differentiation Adipocyte differentiation: a transcriptional regulatory cascade Reversing Adipocyte differentiation: implications for treatment of obesity Regulation of Adipocyte differentiation and function by polyunsaturated fatty acids Thyroid hormone and Adipocyte differentiation PPARγ in the control of brown Adipocyte differentiation PPARγ in Adipocyte differentiation and metabolism–novel insights from genome-wide studies Changes in integrin expression during Adipocyte differentiation The peroxisome proliferator activated receptors (PPARS) and their effects on lipid metabolism and Adipocyte differentiation Regulatory circuits controlling white versus brown Adipocyte differentiation Role of the CCAAT enhancer binding proteins (C/EBPs) in Adipocyte differentiation Bifunctional role of Rev-erbα in Adipocyte differentiation Evidence of Adipocyte differentiation in human orbital fibroblasts in primary culture ADD1/SREBP1 promotes Adipocyte differentiation and gene expression linked to fatty acid metabolism. Nucleoprotein complexes that regulate gene expression in Adipocyte differentiation: direct participation of c-fos Opposing roles of pRB and p107 in Adipocyte differentiation Paracrine regulation of angiogenesis and Adipocyte differentiation during in vivo adipogenesis Down-regulation of histone deacetylases stimulates Adipocyte differentiation Alteration of chromosome positioning during Adipocyte differentiation Posttranscriptional control of Adipocyte differentiation through activation of phosphoinositide 3-kinase Regulation of Adipocyte differentiation and insulin action with rapamycin miR-27a is a negative regulator of Adipocyte differentiation via suppressing PPARγ expression The role of growth hormone/insulin-like growth factors in Adipocyte differentiation S6K1 plays a critical role in early Adipocyte differentiation Adipocyte differentiation of bone marrow-derived mesenchymal stem cells: cross talk with the osteoblastogenic program The forkhead transcription factor Foxo1 regulates Adipocyte differentiation MiRNA expression profile of human subcutaneous adipose and during Adipocyte differentiation Characterization of Adipocyte differentiation from human mesenchymal stem cells in bone marrow Adipocyte differentiation induces dynamic changes in NF-κB expression and activity Reactive oxygen species facilitate Adipocyte differentiation by accelerating mitotic clonal expansion The Expression and Regulation of STATs during 3T3-L1 Adipocyte differentiation (∗) A cysteine-rich adipose tissue-specific secretory factor inhibits Adipocyte differentiation Retinoblastoma protein positively regulates terminal Adipocyte differentiation through direct interaction with C/EBPs. Cascade regulation of terminal Adipocyte differentiation by three members of the C/EBP family of leucine zipper proteins. Metabolic phenotyping of a model of
SGLT inhibitors in management of diabetes Structural selectivity of human SGLT inhibitors A novel approach to control hyperglycemia in type 2 diabetes: Sodium glucose co-transport (SGLT) inhibitors. Systematic review and meta-analysis of randomized … SGLT inhibitors as antidiabetic agents: a comprehensive review International consensus on risk management of diabetic ketoacidosis in patients with type 1 diabetes treated with sodium–glucose cotransporter (SGLT) inhibitors SGLT inhibitors in type 1 diabetes: weighing efficacy and side effects SGLT inhibitors for type 1 diabetes: proceed with extreme caution SGLT inhibitors attenuate NO-dependent vascular relaxation in the pulmonary artery but not in the coronary artery Strategy for mitigating DKA risk in patients with type 1 diabetes on adjunctive treatment with SGLT inhibitors: a STICH protocol SGLT inhibitors for type 1 diabetes: an obvious choice or too good to be true? The anti-inflammatory effects of SGLT inhibitors Na+-Glucose Cotransporter (SGLT) inhibitors as Antidiabetic Agents. 4. Synthesis and Pharmacological Properties of 4'-Dehydroxyphlorizin Derivatives Substituted … SGLT inhibitors as new therapeutic tools in the treatment of diabetes natural products as lead compounds for sodium glucose cotransporter (SGLT) inhibitors SGLT inhibitors for people with type 1 diabetes SGLT inhibitors: a novel target for diabetes Impact of SGLT inhibitors on Multiple Organ Defects in Diabetes. Effects of sodium‐glucose cotransporter (SGLT) inhibitors in addition to insulin therapy on glucose control and safety outcomes in adults with type 1 diabetes: a meta … Pyrazole-O-glucosides as novel Na+-glucose cotransporter (SGLT) inhibitors Synthesis of isotopically labelled SGLT inhibitors and their metabolites Cyclic diarylheptanoids as Na+-glucose cotransporter (SGLT) inhibitors from Acer nikoense A quantitative systems pharmacology kidney model of diabetes associated renal hyperfiltration and the effects of SGLT inhibitors QSAR studies on triazole derivatives as SGLT inhibitors via CoMFA and CoMSIA Diabetic proximal tubulopathy: Can we mimic the disease for in vitro screening of SGLT inhibitors? The bark giving diabetes therapy some bite: the SGLT inhibitors Effect of SGLT inhibitors on weight and lipid metabolism at 24 weeks of treatment in patients with diabetes mellitus: A systematic review and network meta … Synthesis of L-rhamnose derived chiral bicyclic triazoles as novel sodium-glucose transporter (SGLT) inhibitors SGLT inhibitors and euglycaemic diabetic ketoacidosis: earlier observations rediscovered Commentary: SGLT inhibitors in type 1 diabetes: Place in therapy and a risk mitigation strategy for preventing diabetic ketoacidosis‐the STOP DKA protocol Synthesis of novel l-rhamnose derived acyclic C-nucleosides with substituted 1, 2, 3-triazole core as potent sodium-glucose co-transporter (SGLT) inhibitors SGLT inhibitors for type 1 diabetes Factors that predict glycaemic response to sodium‐glucose linked transporter (SGLT) inhibitors The bark giving diabetes therapy some bite: the SGLT inhibitors SGLT inhibitors attenuate NO‐dependent vascular relaxation in mouse pulmonary artery (677.3) SGLT inhibitors for type 1 diabetes: a finely balanced matter? Empagliflozin, a novel selective sodium glucose cotransporter‐2 (SGLT‐2) inhibitor: characterisation and comparison with other SGLT‐2 inhibitors Novel SGLT inhibitors (SGL5083 and SGL5085), Acting on Both Suppressing Intestinal Glucose Absorption and Increasing Urinary Glucose Excretion, Improve … SGLT-2 inhibitors: pharmacokinetics characteristics and effects on lipids SGLT inhibitors Enhance Endogenous Glucose Productions (EGP) in a
The perils of portliness: causes and consequences of Visceral Adiposity. The clinical importance of Visceral Adiposity: a critical review of methods for Visceral adipose tissue analysis Visceral Adiposity Index: a reliable indicator of Visceral fat function associated with cardiometabolic risk Visceral Adiposity syndrome Relationship of obesity and Visceral Adiposity with serum concentrations of CRP, TNF-α and IL-6 Is Visceral Adiposity the “enemy within”? Point: Visceral Adiposity is causally related to insulin resistance Measures of abdominal obesity assessed for Visceral Adiposity and relation to coronary risk Visceral Adiposity and the risk of metabolic syndrome across body mass index: the MESA Study Sex differences in inflammatory markers: what is the contribution of Visceral Adiposity? Visceral Adiposity, insulin resistance and cancer risk Predictive performance of the Visceral Adiposity index for a Visceral Adiposity-related risk: type 2 diabetes Visceral Adiposity index: an indicator of adipose tissue dysfunction Visceral Adiposity and risk of type 2 diabetes: a prospective study among Japanese Americans. Visceral Adiposity as a target for the management of the metabolic syndrome Visceral Adiposity and the risk of impaired glucose tolerance: a prospective study among Japanese Americans Clinical significance of Visceral Adiposity assessed by computed tomography: a Japanese perspective Leptin selectively decreases Visceral Adiposity and enhances insulin action. Molecular evidence supporting the portal theory: a causative link between Visceral Adiposity and hepatic insulin resistance Visceral Adiposity is an independent predictor of incident hypertension in Japanese Americans Sleep apnoea and Visceral Adiposity in middle-aged male and female subjects Visceral Adiposity and the prevalence of hypertension in Japanese Americans Intestinal permeability is associated with Visceral Adiposity in healthy women The relationship between Visceral Adiposity and cognitive performance in older adults Cut-off points of the Visceral Adiposity index (VAI) identifying a Visceral adipose dysfunction associated with cardiometabolic risk in a Caucasian Sicilian … Adipocytokines attenuate the association between Visceral Adiposity and diabetes in older adults Maternal Visceral Adiposity by consistency of lactation Aortic stiffness is associated with Visceral Adiposity in older adults enrolled in the study of health, aging, and body composition Effect of growth hormone on body composition and Visceral Adiposity in middle-aged men with Visceral obesity Pathogenic potential of adipose tissue and metabolic consequences of adipocyte hypertrophy and increased Visceral Adiposity … between abdominal subcutaneous and Visceral Adiposity, liver fat, and cardiometabolic risk profile: the International Study of Prediction of Intra-Abdominal Adiposity … Effects of exercise intensity on cardiovascular fitness, total body composition, and Visceral Adiposity of obese adolescents Adipokines, inflammation, and Visceral Adiposity across the menopausal transition: a prospective study Effect of aerobic exercise training dose on liver fat and Visceral Adiposity Counterpoint: Visceral Adiposity is not causally related to insulin resistance Adiponectin in youth: relationship to Visceral Adiposity, insulin sensitivity, and β-cell function Relationship between Visceral Adiposity and bone mineral density in Korean adults Visceral Adiposity and its anatomical distribution as predictors of the metabolic syndrome and cardiometabolic risk factor levels Visceral Adiposity is associated with serum retinol binding protein‐4 levels in healthy women The Visceral Adiposity syndrome in Japanese‐American men Asian
Methionine restriction extends lifespan through various mechanisms, including alterations in translation rate or accuracy, modulation of DNA methylation patterns and gene expression, changes in glutathione levels or distribution, changes in endocrine levels, hormesis, lowering of insulin and IGF-1 levels, activation of stress response pathways, reduction of oxidative stress, and alteration of gene expression. These mechanisms contribute to the beneficial effects of methionine restriction on lifespan. Natural ways to restrict methionine in the diet include consuming a plant-based diet, emphasizing low-methionine foods, limiting high-methionine animal products, including methionine-restricted foods, and practicing intermittent fasting. A review of METHIONINE dependency and the role of METHIONINE Restriction in cancer growth control and life-span extension Life-span extension in mice by preweaning food Restriction and by METHIONINE Restriction in middle age Exploiting METHIONINE Restriction for cancer treatment The low-METHIONINE content of vegan diets may make METHIONINE Restriction feasible as a life extension strategy METHIONINE Restriction and lifespan control METHIONINE Restriction and cancer biology Mechanisms of increased in vivo insulin sensitivity by dietary METHIONINE Restriction in mice Pleiotropic responses to METHIONINE Restriction The impact of dietary METHIONINE Restriction on biomarkers of metabolic health METHIONINE Restriction inhibits colon carcinogenesis METHIONINE Restriction increases blood glutathione and longevity in F344 rats METHIONINE Restriction on lipid metabolism and its possible mechanisms Regulation of longevity and oxidative stress by nutritional interventions: role of METHIONINE Restriction Role of β-adrenergic receptors in the hyperphagic and hypermetabolic responses to dietary METHIONINE Restriction METHIONINE Restriction prevents onset of type 2 diabetes in NZO mice Metabolic regulation of METHIONINE Restriction in diabetes METHIONINE Restriction restores a younger metabolic phenotype in adult mice with alterations in fibroblast growth factor 21 Concentration‐dependent linkage of dietary METHIONINE Restriction to the components of its metabolic phenotype Dietary METHIONINE Restriction increases fat oxidation in obese adults with metabolic syndrome Forty percent and eighty percent METHIONINE Restriction decrease mitochondrial ROS generation and oxidative stress in rat liver METHIONINE Restriction decreases mitochondrial oxygen radical generation and leak as well as oxidative damage to mitochondrial DNA and proteins From yeast to human: exploring the comparative biology of METHIONINE Restriction in extending eukaryotic life span Physiological and molecular mechanisms of METHIONINE Restriction Metabolic adaptations to METHIONINE Restriction that benefit health and lifespan in rodents METHIONINE Restriction extends lifespan of Drosophila melanogaster under conditions of low amino-acid status Remodeling the integration of lipid metabolism between liver and adipose tissue by dietary METHIONINE Restriction in rats Dietary METHIONINE Restriction enhances metabolic flexibility and increases uncoupled respiration in both fed and fasted states Calorie Restriction and METHIONINE Restriction in control of endogenous hydrogen sulfide production by the transsulfuration pathway Nutrient intake and nutritional indexes in adults with metastatic cancer on a phase I clinical trial of dietary METHIONINE Restriction UCP1 is an essential mediator of the effects of METHIONINE Restriction on energy balance but not insulin sensitivity The components of age‐dependent effects of dietary METHIONINE Restriction on energy balance in rats Histone methylation status of H3K4me3 and H3K9me3 under METHIONINE Restriction is unstable in METHIONINE-addicted cancer cells, but
Spectrophotometric analysis of flavonoid–DNA binding interactions at physiological conditions Flavonoid–DNA binding studies and thermodynamic parameters Spectrophotometric analysis of flavonoid-DNA interactions and DNA damaging/protecting and cytotoxic potential of flavonoids in human peripheral blood lymphocytes Flavonoid effects on DNA oxidation at low concentrations relevant to physiological levels Absorption and DNA protective effects of flavonoid glycosides from an onion meal Luteolin, an emerging anti-cancer flavonoid, poisons eukaryotic DNA topoisomerase I The citrus flavonoid naringenin stimulates DNA repair in prostate cancer cells Quercetin, a natural flavonoid interacts with DNA , arrests cell cycle and causes tumor regression by activating mitochondrial pathway of apoptosis Flavonoid-DNA interaction studied with flow linear dichroism technique repair of iron-induced DNA oxidation by the flavonoid myricetin in primary rat hepatocyte cultures Evidence of covalent binding of the dietary flavonoid quercetin to DNA and protein in human intestinal and hepatic cells Interaction of antioxidant flavonoids with tRNA: intercalation or external binding and comparison with flavonoid-DNA adducts UVB-induced DNA damage, generation of reactive oxygen species, and inflammation are effectively attenuated by the flavonoid luteolin in vitro and in vivo Expression of DNA repair and metabolic genes in response to a flavonoid-rich diet Oxidative DNA cleavage induced by an iron (III) flavonoid complex: Synthesis, crystal structure and characterization of chlorobis (flavonolato)(methanol) iron (III) … Melatonin may increase disease resistance and flavonoid biosynthesis through effects on DNA methylation and gene expression in grape berries Estrogen-and stress-induced DNA damage in breast cancer and chemoprevention with dietary flavonoid Analysis of T-DNA alleles of flavonoid biosynthesis genes in Arabidopsis ecotype Columbia Apigenin, a dietary flavonoid, induces apoptosis, DNA damage, and oxidative stress in human breast cancer MCF-7 and MDA MB-231 cells Effects of flavonoid extract Enzogenol® with vitamin C on protein oxidation and DNA damage in older human subjects Troxerutin, a natural flavonoid binds to DNA minor groove and enhances cancer cell killing in response to radiation Structure-activity studies of the binding of the flavonoid scaffold to DNA Ultraviolet light inhibition of phytochrome-induced flavonoid biosynthesis and DNA photolyase formation in mustard cotyledons (Sinapis alba L.) DNA binding interaction studies of flavonoid complexes of Cu (II) and Fe (II) and determination of their chemotherapeutic potential Impact of xanthohumol (a prenylated flavonoid from hops) on DNA stability and other health‐related biochemical parameters: Results of human intervention trials Flavonoid-enriched apple fraction AF4 induces cell cycle arrest, DNA topoisomerase II inhibition, and apoptosis in human liver cancer HepG2 cells Apigenin, a bioactive flavonoid from Lycopodium clavatum, stimulates nucleotide excision repair genes to protect skin keratinocytes from ultraviolet B-induced … Wogonin, a natural flavonoid, intercalates with genomic DNA and exhibits protective effects in IL-1β stimulated osteoarthritis chondrocytes Diversity of genetic lesions characterizes new Arabidopsis flavonoid pigment mutant alleles from T-DNA collections Xanthohumol, a Prenylated flavonoid from hops, induces DNA damages in colorectal Cancer cells and sensitizes SW480 cells to the SN38 chemotherapeutic agent Membrane and genomic DNA dual-targeting of citrus flavonoid naringenin against Staphylococcus aureus Flavonoid glycoside: A new inhibitor of eukaryotic DNA polymerase α and a new carrier for inhibitor-affinity chromatography
Calorie Restriction—the SIR2 connection How does Calorie Restriction work? Calorie Restriction and aging: review of the literature and implications for studies in humans Aging, adiposity, and Calorie Restriction Calorie Restriction and SIR2 genes—towards a mechanism Requirement of NAD and SIR2 for life-span extension by Calorie Restriction in Saccharomyces cerevisiae Sir2-independent life span extension by Calorie Restriction in yeast Sir2 mediates longevity in the fly through a pathway related to Calorie Restriction Calorie Restriction and aging: A life‐history analysis Increase in activity during Calorie Restriction requires Sirt1 Relative effects of Calorie Restriction and weight loss in noninsulin-dependent diabetes mellitus Calorie Restriction in rhesus monkeys The inflammation hypothesis of aging: molecular modulation by Calorie Restriction Calorie Restriction and cancer prevention: metabolic and molecular mechanisms Calorie Restriction mimetics: an emerging research field Development of Calorie Restriction mimetics as a prolongevity strategy Molecular mechanisms linking Calorie Restriction and longevity Long-term Calorie Restriction is highly effective in reducing the risk for atherosclerosis in humans Tissue-specific regulation of SIRT1 by Calorie Restriction Calorie Restriction and prevention of age-associated chronic disease Calorie Restriction, SIRT1 and metabolism: understanding longevity Calorie Restriction in primates: will it work and how will we know? Calorie Restriction, aging, and cancer prevention: mechanisms of action and applicability to humans HST2 mediates SIR2-independent life-span extension by Calorie Restriction SIR2: a potential target for Calorie Restriction mimetics Mammalian sirtuins—emerging roles in physiology, aging, and Calorie Restriction Nicotinamide and PNC1 govern lifespan extension by Calorie Restriction in Saccharomyces cerevisiae Calorie Restriction and the exercise of chromatin Molecular inflammation hypothesis of aging based on the anti‐aging mechanism of Calorie Restriction Calorie Restriction: what recent results suggest for the future of ageing research Calorie Restriction promotes mitochondrial biogenesis by inducing the expression of eNOS Calorie Restriction extends Saccharomyces cerevisiae lifespan by increasing respiration Effect of Calorie Restriction with or without exercise on body composition and fat distribution Oxidative stress and mitochondrial function with aging–the effects of Calorie Restriction Calorie Restriction alters mitochondrial protein acetylation Sir2 and Calorie Restriction in yeast: a skeptical perspective Calorie Restriction and stroke Intermittent versus daily Calorie Restriction: which diet regimen is more effective for weight loss? SIRT1 transgenic mice show phenotypes resembling Calorie Restriction Calorie Restriction increases muscle mitochondrial biogenesis in healthy humans Calorie Restriction or exercise: effects on coronary heart disease risk factors. A randomized, controlled trial Short-term Calorie Restriction enhances skeletal muscle stem cell function Calorie Restriction induces mitochondrial biogenesis and bioenergetic efficiency Effect of Calorie Restriction on the metabolic history of chronologically aging yeast Calorie Restriction: is AMPK a key sensor and effector? Tor1/Sch9-regulated carbon source substitution is as effective as Calorie Restriction in life span extension NRF2, cancer and Calorie Restriction Calorie Restriction increases life span: a molecular mechanism Chronic Calorie Restriction attenuates experimental autoimmune encephalomyelitis Calorie Restriction and resveratrol in cardiovascular health and disease Calorie Restriction extends yeast life span by lowering the level of NADH Calorie Restriction and aging in nonhuman primates Mitochondria—a nexus for aging, Calorie Restriction, and sirtuins? Calorie Restriction: decelerating mTOR-driven aging from cells
Natural products as anti-glycation agents : possible therapeutic potential for diabetic complications Antioxidative and Anti-glycation Activity of Garcinol from Garcinia indica Fruit Rind Effects of OPB‐9195, anti‐glycation agent, on experimental diabetic neuropathy Antioxidant and Anti-glycation properties of Thai herbal teas in comparison with conventional teas Comparison of Anti-glycation capacities of several herbal infusions with that of green tea Antioxidative activity, polyphenolic content and Anti-glycation effect of some Thai medicinal plants traditionally used in diabetic patients Antioxidant, Anti-glycation and anti-inflammatory activities of phenolic constituents from Cordia sinensis Reconstructed skin modified by glycation of the dermal equivalent as a model for skin aging and its potential use to evaluate Anti-glycation molecules Free radical scavenging, Anti-glycation and tyrosinase inhibition properties of a polysaccharide fraction isolated from the rind from Punica granatum Anti-glycation activity of gold nanoparticles Anti-glycation effect of gold nanoparticles on collagen Inhibitory effect of mung bean extract and its constituents vitexin and isovitexin on the formation of advanced glycation endproducts Inhibition of advanced glycation endproduct formation by foodstuffs The enzymatic defence against glycation in health, disease and therapeutics: a symposium to examine the concept Plant-derived agents with Anti-glycation activity Innovative cosmeceuticals: sirtuin activators and Anti-glycation compounds Advanced glycation endproducts—role in pathology of diabetic complications Anti-glycation effect of mixed herbal extract in individuals with pre-diabetes mellitus a double-blind, placebo-controlled, parallel group study Cyclopeptide alkaloids of Ziziphus oxyphylla Edgw as novel inhibitors of α-glucosidase enzyme and protein glycation Stability and Anti-glycation properties of intermediate moisture apple products fortified with green tea Effects of thermal denaturation on protein glycation Anti-glycation and anti-albuminuric effects of GLY-230 in human diabetes Use of aminoguanidine (Pimagedine) to prevent the formation of advanced glycation endproducts Substituted benzenediol Schiff bases as promising new anti-glycation agents glycation stress and photo-aging in skin Advanced glycation endproducts in ageing and Alzheimer's disease Investigation of antioxidant and Anti-glycation properties of essential oils from fruits and branchlets of Juniperus oblonga Anti-glycation effect of spices and chilies uses in traditional mexican cuisine Advanced glycation in health and disease: role of the modern environment Xanthones inhibitors of α-glucosidase and glycation from Garcinia nobilis Role of advanced glycation end products in diabetic neuropathy Advanced glycation endproducts (AGEs): pharmacological inhibition in diabetes Advanced glycation end products: key players in skin aging? Novel Anti-glycation therapeutic agents : glyoxalase I mimetics Water extracts of cinnamon and clove exhibits potent inhibition of protein glycation and anti-atherosclerotic activity in vitro and in vivo hypolipidemic activity in … Glyoxalase I–structure, function and a critical role in the enzymatic defence against glycation Anti-AGEing defences against Alzheimer's disease Natural inhibitors of advanced glycation end‐products The road to advanced glycation end products: a mechanistic perspective Carnosine and anserine in chicken: Distribution, age-dependency and their Anti-glycation activity Inhibitory effect of naturally occurring flavonoids on the formation of advanced glycation endproducts Flavonol glycosides from the leaves of Eucommia ulmoides O. with glycation inhibitory activity Renal clearance of glycation adducts: Anti-glycation defence in uraemia and dialysis Structural characterization of water-soluble polysaccharides from Opuntia monacantha cladodes in relation to their anti-glycated