(Acacetin), Apigenin 7-O-Apioside (Apiin), 5, 7-Dihydroxyflavone (Chrysin) And Luteolin); Anti-Inflammatory 5-Lox Inhibitors (5, 6, 7-Trihydroxyflavone (Baicalein), 5, 6, 3 … (Aspalathus Linearis) Extract And Water-Soluble Nanomicelles Of Green Rooibos Extract Encapsulated With Ascorbic Acid For Enhanced Aspalathin Content In Ready-To … Acute Assessment Of An Aspalathin-Enriched Green Rooibos (Aspalathus Linearis) Extract With Hypoglycemic Potential Ameliorative Effect Of Aspalathin And Nothofagin From Rooibos (Aspalathus Linearis) On Hmgb1-Induced Septic Responses In Vitro And In Vivo Ameliorative Effect Of Aspalathin From Rooibos (Aspalathus Linearis) On Acute Oxidative Stress In Caenorhabditis Elegans An In Vitro And In Vivo Hepatotoxicity Study Of An Aspalathin-Rich Green Rooibos Extract An Investigation Into The Effects Of Aspalathin On Myocardial Glucose Transport Using Cardiomyocytes From Control And Obesity-Induced Insulin Resistant Rats, And … Anti-Inflammatory Effects Of Aspalathin And Nothofagin From Rooibos (Aspalathus Linearis) In Vitro And In Vivo Antioxidant Activity Of The Dihydrochalcones Aspalathin And Nothofagin And Their Corresponding Flavones In Relation To Other Rooibos (Aspalathus Linearis) Flavonoids … Antithrombotic Activities Of Aspalathin And Nothofagin Via Inhibiting Platelet Aggregation And Fiia/Fxa Aspalathin A Unique Phytochemical From The South African Rooibos Plant (Aspalathus Linearis): A Mini Review Aspalathin Ameliorates Doxorubicin-Induced Oxidative Stress In H9C2 Cardiomyoblasts Aspalathin And Nothofagin From Rooibos (Aspalathus Linearis) Inhibit Endothelial Protein C Receptor Shedding In Vitro And In Vivo Aspalathin And Nothofagin From Rooibos (Aspalathus Linearis) Inhibits High Glucose-Induced Inflammation In Vitro And In Vivo Aspalathin From Aspalathus Linearis (Rooibos) Reduces Osteoclast Activity And Increases Osteoblast Activity In Vitro Aspalathin From Rooibos (Aspalathus Linearis): A Bioactive C-Glucosyl Dihydrochalcone With Potential To Target The Metabolic Syndrome Aspalathin Improves Glucose And Lipid Metabolism In 3T3‐L1 Adipocytes Exposed To Palmitate Aspalathin Improves Hyperglycemia And Glucose Intolerance In Obese Diabetic Ob/Ob Mice Aspalathin Protects Insulin‐Producing Β Cells Against Glucotoxicity And Oxidative Stress‐Induced Cell Death Aspalathin Protects The Heart Against Hyperglycemia-Induced Oxidative Damage By Up-Regulating Nrf2 Expression Aspalathin Reverts Doxorubicin-Induced Cardiotoxicity Through Increased Autophagy And Decreased Expression Of P53/Mtor/P62 Signaling Aspalathin, A C-Glucosyl Dihydrochalcone From Rooibos Improves The Hypoglycemic Potential Of 1 Metformin In Type 2 Diabetic (Db/Db) Mice 2 Aspalathin, A C-Glucosyl Dihydrochalcone From Rooibos Improves The Hypoglycemic Potential Of Metformin In Type 2 Diabetic (Db/Db) Mice Aspalathin, A Dihydrochalcone C‐Glucoside, Protects H9C2 Cardiomyocytes Against High Glucose Induced Shifts In Substrate Preference And Apoptosis Aspalathin, A Flavonoid In Aspalathus Linearis (Rooibos), Is Absorbed By Pig Intestine As A C-Glycoside Aspalathin, A Natural Product With The Potential To Reverse Hepatic Insulin Resistance By Improving Energy Metabolism And Mitochondrial Respiration Aspalathin-Enriched Green Rooibos Extract Reduces Hepatic Insulin Resistance By Modulating Pi3K/Akt And Ampk Pathways Aspalathin-Rich Green Rooibos Extract Lowers Ldl-Cholesterol And Oxidative Status In High-Fat Diet-Induced Diabetic Vervet Monkeys C-Glycosylflavonoids. The Chemistry Of Aspalathin Comparison Of The Antioxidant Activity Of Aspalathin With That Of Other Plant Phenols Of Rooibos Tea (Aspalathus Linearis), Α-Tocopherol, Bht, And Bha Concise And Scalable Synthesis Of Aspalathin, A Powerful Plasma Sugar-Lowering Natural Product Concise Total Syntheses Of Aspalathin And Nothofagin Correction: Van Der Merwe, Jd, Et Al. Short-Term And Sub-Chronic Dietary Exposure To Aspalathin-Enriched Green Rooibos (Aspalathus
(Acacetin), Apigenin 7-O-Apioside (Apiin), 5, 7-Dihydroxyflavone (Chrysin) And Luteolin); Anti-Inflammatory 5-Lox Inhibitors (5, 6, 7-Trihydroxyflavone (Baicalein), 5, 6, 3 … , Modification Of Artocarpin Compound From Pudau Plant (Artocarpus Kemando Miq.) And Bioactivity Antibacterial Assay Of Artocarpin … Antihepatoma Activity Of Artocarpus Communis Is Higher In Fractions With High Artocarpin Content Antipneumococcal Activity Of Neuraminidase Inhibiting Artocarpin Artin M: A Rational Substitution For The Names Artocarpin And Km+ Artocarpin Attenuates Ultraviolet B-Induced Skin Damage In Hairless Mice By Antioxidant And Anti-Inflammatory Effect Artocarpin Attenuates Ultraviolet B-Induced Skin Damage In Hairless Mice By Antioxidant And Anti-Inflammatory Effects Artocarpin Dichloromethane Hemisolvate Artocarpin Induces Apoptosis In Human Cutaneous Squamous Cell Carcinoma Hsc-1 Cells And Its Cytotoxic Activity Is Dependent On Protein-Nutrient Concentration Artocarpin Induces Cell Apoptosis In Human Osteosarcoma Cells Through Endoplasmic Reticulum Stress And Reactive Oxygen Species Artocarpin Is A Polyspecific Jacalin-Related Lectin With A Monosaccharide Preference For Mannose Artocarpin Isolated From Artocarpus Heterophyllus Heartwoods Alters Membrane Permeability Of Streptococcus Mutans Artocarpin, A Promising Compound As Whitening Agent And Anti-Skin Cancer Artocarpin, An Isoprenyl Flavonoid, Induces P53-Dependent Or Independent Apoptosis Via Ros-Mediated Mapks And Akt Activation In Non-Small Cell Lung … Artocarpin‐Enriched (Artocarpus Altilis) Heartwood Extract Provides Protection Against Uvb‐Induced Mechanical Damage In Dermal Fibroblasts Artocarpin-Enriched Extract Reverses Collagen Metabolism In Uv-Exposed Fibroblasts Artocarpin-Galactomannan Interaction: Characterization Of Combining Site Of Artocarpin Binding Mechanism Of Methyl-Α-N-Acetyl-D-Galactopyranosyl Amine To Artocarpus Lakoocha Lectin, Artocarpin: A Proton Nuclear Magnetic Resonance Study Characterization Of Carbohydrate Specificity And Primary Structure Of The B-Cell Mitogen, Artocarpin, From Artocarpus Integrifolia Seeds Chemical Modification Studies Of Artocarpus Lakoocha Lectin Artocarpin Chemistry And Pharmacology Of Artocarpin: An Isoprenyl Flavone From Artocarpus Species Chemoprevention Of Colorectal Cancer By Artocarpin, A Dietary Phytochemical From Artocarpus Heterophyllus Correction: Artocarpin, An Isoprenyl Flavonoid, Induces P53-Dependent Or Independent Apoptosis Via Ros-Mediated Mapks And Akt Activation In Non-Small Cell Lung … Crystal Structures Of Artocarpin, A Moraceae Lectin With Mannose Specificity, And Its Complex With Methyl-Α-D-Mannose: Implications To The Generation Of Carbohydrate … Cytotoxic Effect Of Artocarpin On T47D Cells Effects Of CycloArtocarpin A And Artocarpin Extracted From Fructus Artocarpin Heterophylli On Apoptosis Of Smmc-7721 And Sgc-7901 Cells Enhanced Autophagic Activity Of Artocarpin In Human Hepatocellular Carcinoma Cells Through Improving Its Solubility By A Nanoparticle System Further Characterization Of Artocarpus Lakoocha Lectin (Artocarpin) Purified Using Rivanol Homology Between Jacalin And Artocarpin From Jackfruit (Artocarpus Integrifolia) Seeds. Partial Sequence And Preliminary Crystallographic Studies Of Artocarpin Identification Of Cytochrome P450 Isoforms Involved In The Metabolism Of Artocarpin And Assessment Of Its Drug–Drug Interaction Immunogenicity And Modulatory Effect Of The Lectins From Al-Tocal-Pus Hetel-Ophyllus (Jackfruit) Seeds, Artocarpin And Jacalin Interspecies Metabolic Diversity Of Artocarpin In Vitro Mammalian Liver Microsomes Isothermal Titration Calorimetric Studies On The Binding Of Deoxytrimannoside Derivatives With Artocarpin: Implications For A Deep-Seated Combining Site In Lectins Structural Basis For The Carbohydrate Specificities Of Artocarpin: Variation In The Length Of A Loop As A Strategy For Generating Ligand Specificity Synergistic Activity Of Lawsone Methyl Ether In Combination With Some Antibiotics And Artocarpin Against Methicillin-Resistant Staphylococcus Aureus, Candida Albicans …
A Bim-Targeting Strategy Overcomes Adaptive Bortezomib Resistance In Myeloma Through A Novel Link Between Autophagy And Apoptosis A Bioinformatic And Mechanistic Study Elicits The Antifibrotic Effect Of Ursolic Acid Through The Attenuation Of Oxidative Stress With The Involvement Of Erk, Pi3K … A Biomolecular Network-Based Strategy Deciphers The Underlying Molecular Mechanisms Of Bupleuri Radix/Curcumae Radix Medicine Pair In The Treatment Of Hepatitis … A Circadian Clock Is Essential For Homeostasis Of Group 3 Innate Lymphoid Cells In The Gut A Common Bim Deletion Polymorphism Mediates Intrinsic Resistance And Inferior Responses To Tyrosine Kinase Inhibitors In Cancer A Complex Oscillating Network Of Signaling Genes Underlies The Mouse Segmentation Clock A Complex Scenario And Underestimated Challenge: The Tumor Microenvironment, Er Stress, And Cancer Treatment A Comprehensive Molecular Interaction Map For Rheumatoid Arthritis A Constitutive BCL2 Down-Regulation Aggravates The Phenotype Of Pkd1-Mutant-Induced Polycystic Kidney Disease A Cooperative Microrna-Tumor Suppressor Gene Network In Acute T-Cell Lymphoblastic Leukemia (T-All) A Curative Cancer Treatment A Cyclin-D1 Interaction With Bax Underlies Its Oncogenic Role And Potential As A Therapeutic Target In Mantle Cell Lymphoma A Delicate Balance–The BCL-2 Family And Its Role In Apoptosis, Oncogenesis, And Cancer Therapeutics A Drug Library Screen Identifies Carbenoxolone As Novel Foxo Inhibitor That Overcomes Foxo3-Mediated Chemoprotection In High-Stage Neuroblastoma A Fate Worse Than Death: Apoptosis As An Oncogenic Process A Functional Role For Transfer Rna-Derived Micrornas In Human B Cells A Genome Scale Rnai Screen Identifies Gli1 As A Novel Gene Regulating Vorinostat Sensitivity A Genome-Wide Association Study Identifies Six Susceptibility Loci For Chronic Lymphocytic Leukemia A Genome-Wide Search For Tumor Suppressor Micrornas In Ovarian Cancer A Global Network Of Transcription Factors, Involving E2A, Ebf1 And Foxo1, That Orchestrates B Cell Fate A Homeostatic Shift Facilitates Endoplasmic Reticulum Proteostasis Through Transcriptional Integration Of Proteostatic Stress Response Pathways A Landscape Of Therapeutic Cooperativity In Kras Mutant Cancers Reveals Principles For Controlling Tumor Evolution A License To Kill: Understanding Natural Killer Cell Licensing To Fight Cancer A Male Infertility Mutation Reverts Nanos1 Activity From Anti-Apoptotic To Pro-Apoptotic By Disrupting Repression Of Gadd45A, Gadd45B, Gadd45G And Rhob Genes A Microtubule Inhibitor, Abt-751, Induces Autophagy And Delays Apoptosis In Huh-7 Cells A Mini Review Of Bisphenol A (Bpa) Effects On Cancer-Related Cellular Signaling Pathways A Miraculous New Therapy In Myeloma? A Multicenter Clinical Study Evaluating The Confirmed Complete Molecular Response Rate In Imatinib-Treated Patients With Chronic Phase Chronic Myeloid Leukemia By … A Mutation In The Viral Sensor 2'-5'-Oligoadenylate Synthetase 2 Causes Failure Of Lactation A Myc-Dependent Division Timer Complements A Cell-Death Timer To Regulate T Cell And B Cell Responses A Myriad Of Roles Of Mir-25 In Health And Disease A Neuroprotective Agent That Inactivates Prodegenerative Trka And Preserves Mitochondria A New Era Of Cardiac Cell Therapy: Opportunities And Challenges A New Stat3-Binding Partner, Arl3, Enhances The Phosphorylation And Nuclear Accumulation Of Stat3 A New Therapeutic Paradigm For Breast Cancer Exploiting Low Dose Estrogen-Induced Apoptosis A Non-Invasive Test For Assessing Embryo Potential By Gene Expression Profiles Of Human Cumulus Cells: A Proof Of Concept
Epigenetic Modifiers Exacerbate Oxidative Stress In Renal Proximal Tubule Cells Epigenetic Modifiers As Anticancer Drugs: Effectiveness Of Valproic Acid In Neural Crest-Derived Tumor Cells Epigenetic Modifiers Exert Renal Toxicity Through Induction Of P66Shc Combining Oncolytic Viruses With Epigenetic Modifiers To Treat Acute Lymphocytic Leukemias The Role Of Epigenetic Modifiers In Hematopoiesis A Screen For Modifiers Of Epigenetic Reprogramming Essay: The Role Of Epigenetic Modifiers In Non-Hodgkin B Cell Lymphoma Combination Of 5-Fluorouracil With Epigenetic Modifiers Induces Radiosensitization, Somatostatin Receptor 2 Expression, And Radioligand Binding In … Key Actors In Cancer Therapy: Epigenetic Modifiers Epigenetic Modifiers Enhance Vesicular Stomatitis Virus-Mediated Oncolysis In The Refractory Pc3 Cell Line. Sub-Acute Exposure Effect Of Selected Polycyclic Aromatic Hydrocarbons On Protein Levels Of Epigenetic Modifiers In Non-Cancerous Hepatic Model Adipogenic Differentiation Potential Of Stem Cells Under The Influence Of The Epigenetic Modifiers 5-Aza-2´-Deoxycytidine And Suberoylanilide Hydroxamic Acid Somatic Variants In Epigenetic Modifiers Can Predict Failure Of Response To Imatinib But Not To Second-Generation Tyrosine Kinase Inhibitors Spliceosome Mutations Exhibit Specific Associations With Epigenetic Modifiers And Proto-Oncogenes Mutated In Myelodysplastic Syndrome The Epigenetic Modifiers 5-Aza-2'-Deoxycytidine And Trichostatin A Influence Adipocyte Differentiation In Human Mesenchymal Stem Cells Candidate Epigenetic Modifiers Of Tau Pathological Burden In Primary Age-Related Tauopathy Epigenetic Modifiers As New Immunomodulatory Therapies In Solid Tumours 5-Hydroxymethylation-Associated Epigenetic Modifiers Of Alzheimer'S Disease Modulate Tau-Induced Neurotoxicity Effects Of Acute Ethanol Exposure On Anxiety Measures And Epigenetic Modifiers In The Extended Amygdala Of Adolescent Rats Targeted Transcriptional Activation Of Silent Oct4 Pluripotency Gene By Combining Designer Tales And Inhibition Of Epigenetic Modifiers An Efficient Method For Generation Of Bi-Allelic Null Mutant Mouse Embryonic Stem Cells And Its Application For Investigating Epigenetic Modifiers Identification Of Cryptosporidium Kinases And Epigenetic Modifiers As Potential Drug Targets Using A Chemical Genetics Approach Changes In Immunogenicity Of Chronic Lymphocytic Leukemia Cells Mediated By Epigenetic Modifiers Restoring The Functional Immunogenicity Of Chronic Lymphocytic Leukemia Using Epigenetic Modifiers. Ex Vivo Expansion Of Human Mobilized Peripheral Blood Stem Cells Using Epigenetic Modifiers Association Between Micro-Rna And Epigenetic Modifiers Dna Methyltransferases (Dnmts), Histone Deacetylases (Hdacs) In Multiple Myeloma (Mm) And … Mutations In Epigenetic Modifiers In The Pathogenesis And Therapy Of Acute Myeloid Leukemia Transient Activation Of Inflammatory Molecules By Epigenetic Modifiers Likely Plays A Role In Expansion Of Transplantable Human Cord Blood Stem/Progenitor Cells Leukemic Pattern Of Hox Gene Expression Is Driven By Genetic Aberrations Through Epigenetic Modifiers Integrated Genome Sequencing Reveals Frequent Loss Of Function Alterations Of Arid1A And Other Epigenetic Modifiers In Sezary Syndrome Epigenetic Modifying Drugs Inhibit Mds/Aml Cell Growth Through Selective Disruption Of The Interactions Between Lineage-Determining Transcription Factors And … Somatic Mutations In Epigenetic Modifiers Identified Using Next Generation Sequencing (Ngs) In Diagnostic Samples Of Cml-Cp Can Predict Poor Outcome On Imatinib … North American Adult T Cell Leukemia Lymphoma (Atll) Is Characterized By Distinct, Therapeutically Targetable Mutations In Epigenetic Modifiers Impact Of Mutations In Epigenetic Modifiers In Acute Myeloid Leukemia: A Systematic Review And Meta-Analysis Gene Alterations In Epigenetic Modifiers And Jak-Stat Signaling Are Frequent In Breast Implant–Associated Alcl Epigenetic
Evading apoptosis in cancer Carcinogenesis is a mechanistically complex and variable process with a plethora of underlying genetic causes. Cancer development consists of a multitude of steps that occur progressively starting with initial driver mutation(s), to tumorigenesis, and ultimately metastasis. During these transitions, cancer cells accumulate a series of genetic alterations that confer upon the cells an unwarranted survival and proliferative advantage. During the course of development, however, cancer cells also encounter a physiologically ubiquitous cellular program that aims to eliminate damaged or abnormal cells: Apoptosis. Thus, it is essential that cancer cells acquire instruments to circumvent programmed cell death. Here we discuss emerging evidence indicating how cancer cells adopt various strategies to override apoptosis including amplifying the anti-apoptotic machinery, downregulating the pro-apoptotic program, or both. Roles of Apoptosis and Cellular Senescence in Cancer and Aging. Cancer and aging are two similar processes representing the final outcome of timedependent accumulation of various irreversible dysfunctions, mainly caused by stress-induced DNA and cellular damages. Apoptosis and senescence are two types of cellular response to damages that are altered in both cancer and aging, albeit through different mechanisms. Carcinogenesis is associated with a progressive reduction in the ability of the cells to trigger apoptosis and senescence. In contrast, in aging tissues, there is an increased accumulation of senescent cells, and the nature of apoptosis deregulation varies depending on the tissue. Thus, the prevailing model suggests that apoptosis and cellular senescence function as two essential tumor-suppressor mechanisms, ensuring the health of the individual during early and reproductive stages of life, but become detrimental and promote aging later in life. The recent discovery that various anticancer agents, including canonical inducers of apoptosis, act also as inducers of cellular senescence indicates that pro-senescence strategies may have applications in cancer prevention therapy. Therefore, dissection of the mechanisms mediating the delicate balance between apoptosis and cellular senescence will be beneficial in the therapeutic exploitation of both processes in the development of future anticancer and anti-aging strategies, including minimizing the side effects of such strategies. Here, we provide an overview of the roles of apoptosis and cellular senescence in cancer and aging. Cellular senescence (CS) is initially defined as an irreversible growth arrest of normal somatic cells, and has been proposed to contribute to tissue and organismal aging itself, and to be an intrinsic safeguard against tumor progression (1). SCs have been shown to have diverse phenotypes, including cellular flattening and hypertrophy, senescence-associated β-galactosidase activity (SAβG), senescence-associated secretory phenotype (SASP), resistance to apoptotic cell death, alterations in nuclear structure and senescence-associated heterochromatic foci (SAHF), mitochondrial expansion, and signaling events, including upregulation of cell cycle inhibitors and -pro-survival effectors (2). SCs accumulated in various tissues in mice with age, and comprised 5–40% of the total cells, depending on the tissue types (3). Although their number are relatively small in tissues, SCs can cause extensive dysfunction of the microenvironment and damage to surrounding cells and tissues, due to their pro-inflammatory senescence-associated secretory phenotype (SASP). Accumulating evidence suggests that CS plays an
The release of cytokines is central to almost every stage of the immune response to allergens... how do you turn down the cytokines and stop the body from having an allergic reaction? Flavonoids and Polyphenols! … -[Beta] c Receptor Antibody Targets Multiple Effector Cell Populations In Human Nasal Polyps Transplanted Into Immunodeficient Transgenic Human Interleukin-3 (il-3 … … , M; Rolla, G; Ricciardolo, Flm. Nasal IL-17F is related to bronchial IL-17F/neutrophilia and exacerbations in stable atopic severe asthma.. allergy . 70 (2) pp … … , Park JM, Oh CK:(S, S)-formoterol increases the production of IL-4 in mast cells and the airways of a murine asthma model. Int Arch allergy Immunol 133: 380 … … allergy AND AIRWAY INFLAMMATION: Increased Vascularity Of The Bronchial Mucosa In Patients With Severe Asthma And The Role Of Il-17a In Angiogenesis … … and CD19low B Cells in Non-IgEMediated Food allergy of Late Eczematous Reactions in Atopic Dermatitis: Presence of IL-17-and IL-32-Producing Regulatory B … … are Associated with Increased IL-4 but not GATA-3 Expression from Antigen-Stimulated Leukocytes in Atopic Infants (COFAR Observational Study of Food allergy ) … blood cell sulfidoleukotriene generation in the presence of interleukin-3 and whole blood histamine release in honey bee and yellow jacket venom allergy . … immunotherapy on the clinical condition and plasma levels of cytokines IL-4, IL-5, IL-12 and IFNγ and total IgE in patients with seasonal allergy during the Pollen … … Interactions During an Allergic Patch Test Reaction. Increased Activity of ETAF/IL-1, epidermal derived lymphocyte reactivity in persons with type IV allergy … M, Varricchi G, Passalacqua G, Canonica GW. A Critical Evaluation of Anti-IL-13 and Anti-IL-4 Strategies in Severe Asthma. Int Arch allergy Immunol. 2016; 170 … … of Epstein–Barr virus (EBV)-infected natural killer (NK) cell proliferation in patients with severe mosquito allergy ; establishment of an IL-2-dependent NK-like … … of IL-6, and IL-12, and the Chemotactic Cytokine RANTES in Patients with Chronic Sinusitis and Polypoid Disease Clinical Relevance and Relation to allergy … on From Molecular Science to the Treatment of allergy , Corfu, Greece, September 12-16 1998: Mechanisms and pharmacologic control of basophil-derived IL-4 and IL … … Smoke and IL-4 Polymorphism (C-589T) Gene: Environment Interaction Increases Risk of Wheezing in African-American Infants: The Cincinnati Childhood allergy … … To Staphylococcus Aureus Particles Promotes Development Of Antigen-Specific Th2-Type Immunity To Inhaled Antigens Through Production Of Interleukin-1 [alpha](il … 105A/C IL-18 GENE SINGLE NUCLEOTIDE POLYMORPHISM AND HOUSE DUST MITE allergy IN A FILIPINO POPULATION 197 Impaired IL-4-Associated Generation of CCR4-Expressing T Cells in Neonates at Hereditary allergy Risk 23 IL-4 AND IFN-γ PRODUCTION BY LONG TERM T CELL CULTURES IN IgE-MEDIATED COW'S MILK allergy (CMA) A Mouse Model of Mosquito allergy for Study of Antigen–Specific IgE and IgG Subclass Responses, Lymphocyte Proliferation, and IL–4 and IFN–Á Production A novel approach to specific allergy treatment: the recombinant allergen-S-layer fusion protein rSbsC-Bet v 1 matures dendritic cells that prime Th0/Th1 and IL-10 … A possible role of elevated breast milk lactoferrin and the cytokine
Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized Targeting BCL-2 with the BH3 mimetic ABT-199 in estrogen receptor-positive breast cancer Bim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic Gossypol, a BH3 mimetic, induces apoptosis in chronic lymphocytic leukemia cells Sensitization of BCL-2–expressing breast tumors to chemotherapy by the BH3 mimetic ABT-737 The BH3-mimetic GX15-070 synergizes with bortezomib in mantle cell lymphoma by enhancing Noxa-mediated activation of Bak The Bcl-2 specific BH3 mimetic ABT-199: a promising targeted therapy for t (11; 14) multiple myeloma Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa A BH3 mimetic for killing cancer cells ABT-199, a new Bcl-2–specific BH3 mimetic, has in vivo efficacy against aggressive Myc-driven mouse lymphomas without provoking thrombocytopenia Initial testing (stage 1) of the BH3 mimetic ABT‐263 by the pediatric preclinical testing program Treatment of B-RAF mutant human tumor cells with a MEK inhibitor requires Bim and is enhanced by a BH3 mimetic A natural BH3 mimetic induces autophagy in apoptosis-resistant prostate cancer via modulating Bcl-2–Beclin1 interaction at endoplasmic reticulum BH3 mimetic obatoclax enhances TRAIL-mediated apoptosis in human pancreatic cancer cells BH3 mimetic ABT-737 potentiates TRAIL-mediated apoptotic signaling by unsequestering Bim and Bak in human pancreatic cancer cells In vitro effects of the BH3 mimetic,(−)-gossypol, on head and neck squamous cell carcinoma cells Acquired mutations in BCL2 family proteins conferring resistance to the BH3 mimetic ABT-199 in lymphoma A novel BH3 mimetic reveals a mitogen-activated protein kinase–dependent mechanism of melanoma cell death controlled by p53 and reactive oxygen species The BH3 mimetic compound, ABT-737, synergizes with a range of cytotoxic chemotherapy agents in chronic lymphocytic leukemia Reversal of cisplatin resistance with a BH3 mimetic,(−)-gossypol, in head and neck cancer cells: role of wild-type p53 and Bcl-xL Activity of vincristine, L-ASP, and dexamethasone against acute lymphoblastic leukemia is enhanced by the BH3-mimetic ABT-737 in vitro and in vivo BH3 mimetic ABT-737 neutralizes resistance to FLT3 inhibitor treatment mediated by FLT3-independent expression of BCL2 in primary AML blasts Modulation of NOXA and MCL-1 as a strategy for sensitizing melanoma cells to the BH3-mimetic ABT-737 MET-independent lung cancer cells evading EGFR kinase inhibitors are therapeutically susceptible to BH3 mimetic agents BH3 mimetic ABT-737 and a proteasome inhibitor synergistically kill melanomas through Noxa-dependent apoptosis Targeting Bcl-2 family members with the BH3 mimetic AT-101 markedly enhances the therapeutic effects of chemotherapeutic agents in in vitro and in vivo models of B … BCL-2 phosphorylation modulates sensitivity to the BH3 mimetic GX15-070 (Obatoclax) and reduces its synergistic interaction with bortezomib in chronic … A novel BH3 mimetic S1 potently induces Bax/Bak‐dependent apoptosis by targeting both Bcl‐2 and Mcl‐1 A phase 2 study of the BH3 mimetic BCL2 inhibitor navitoclax (ABT-263) with or without rituximab, in previously untreated B-cell chronic
“Photoaging is the term used to describe the clinical, histologic, and functional changes in chronically sun-exposed skin of middle-aged and elderly adults. The importance of photoaging lies in its cosmetic and hence psychosocial impact on a large percentage of older adults, its intimate but incompletely understood relationship to skin cancer, as well as various functional losses in skin, and the model it provides for studies of adverse environmental effects on human health. Photoaging is widely presumed to have an adverse effect on essentialy all skin functions, although very few controlled data exist to support this belief. Nuclear atypia and often some degree of disordered keratinocyte maturation are present in moderate to severe photoaging. The depth and severity of the changes are dependent on skin type and the degree of photoaging. The different characteristics of mild, moderate, and severe photoaging in lightly pigmented vs. darkly pigmented skin may also reflect the characteristic response pattern of many cells to increasing injury.” “Chronic sun exposure causes photoaging of human skin, a process that is characterized by clinical, histological and biochemical changes which differ from alterations in chronologically aged but sun‐protected skin. Within recent years, substantial progress has been made in unraveling the underlying mechanisms of photoaging. Induction of matrix metalloproteinases as a consequence of activator protein (AP)‐1 and nuclear factor (NF)‐κB activation as well as mutations of mitochondrial DNA have been identified recently. This has increased our understanding of photoaging significantly and has led to new prophylactic and therapeutic strategies aimed at the prevention and repair of the detrimental effects of chronic sun‐exposure on the skin.” … epidermal barrier function, are 3-hydroxy-3-methylglutaryl-coenzyme A reductase activators, useful to eg fight against signs of cutaneous aging and photoaging 009 skin aging and photoaging effects can be quantified in vivo by fluoresence excitation spectroscopy A dermatologist's ammunition in the war against smoking: a photoaging app A full‐UV spectrum absorbing daily use cream protects human skin against biological changes occurring in photoaging A mixture of extracts of Kochia scoparia and Rosa multiflora with PPAR α/γ dual agonistic effects prevents photoaging in hairless mice A novel anti-photoaging ingredient with the effect of iron sequestering A novel in vivo model for evaluating agents that protect against ultraviolet A-induced photoaging A nuclear factor kappa B-derived inhibitor tripeptide inhibits UVB-induced photoaging process A Peptide YGDEY from Tilapia Gelatin Hydrolysates Inhibits UVB‐mediated skin photoaging by Regulating MMP‐1 and MMP‐9 Expression in HaCaT Cells Adaptive and maladaptive responses in skin: mild heat exposure protects against UVB-induced photoaging in mice Adaptive antioxidant response and photoaging ADSCs inhibit photoaging‐and photocarcinogenesis‐related inflammatory responses and extracellular matrix degradation Advance in Botanical Extract in the Prevention of photoaging [J] Aging-and photoaging-dependent changes of enzymic and nonenzymic antioxidants in the epidermis and dermis of human skin in vivo Alpha-pinene attenuates UVA-induced photoaging through inhibition of matrix metalloproteinases expression in mouse skin An Endogenous Dermal Fluorescence Band that may Serve as a Quantitative Marker of Aging and Photoaging An extract of Polypodium leucotomos inhibits ultraviolet B photoaging in the
A 4-Week Repeated Oral Dose Toxicity Study Of Fucoidan From The Sporophyll Of Undaria Pinnatifida In Sprague–Dawley Rats A Case Of Symptomatic Inflammatory Tongue Treated With Fucoidan A Comparative Study Of Antithrombotic Activities Of Fucoidan With Different Molecular Weight And Its Mechanism A Comparison Of Fucoidan Conjugated To Paclitaxel And Curcumin For The Dual Delivery Of Cancer Therapeutic Agents A Comparison Of The Effect Of Fucoidan From Alga Fucus Vesiculosus And Its Fractions Obtained By Anion-Exchange Chromatography On Hela G-63, Hep G2, And Chang … A Fluorometric Assay For Quantification Of Fucoidan, A Sulfated Polysaccharide From Brown Algae A Fucoidan Fraction From Ascophyllum Nodosum A Fucoidan Fraction Purified From Chnoospora Minima; A Potential Inhibitor Of Lps-Induced Inflammatory Responses A Fucoidan From Nemacystus Decipiens Disrupts Angiogenesis Through Targeting Bone Morphogenetic Protein 4 A Fucoidan From Sea Cucumber Pearsonothuria Graeffei With Well-Repeated Structure Alleviates Gut Microbiota Dysbiosis And Metabolic Syndromes In Hfd-Fed Mice A Fucoidan-Quaternary Chitosan Nanoparticle Adjuvant For Anthrax Vaccine As An Alternative To Cpg Oligodeoxynucleotides A Highly Regular Fraction Of A Fucoidan From The Brown Seaweed Fucus Distichus L. A Low Molecular Weight Fucoidan Fraction From The Brown Seaweed Pelvetia Canaliculata A Marine Strain Of Flavobacteriaceae Utilizes Brown Seaweed Fucoidan A Marine-Sourced Fucoidan Solution Inhibits Toll-Like-Receptor-3-Induced Cytokine Release By Human Bronchial Epithelial Cells A Method For Coating Fucoidan Onto Bare Metal Stent And In Vivo Evaluation A New Extraction Method Of Fucoidan From The Soaked Water Of Brown Seaweed (Laminaria Japonica) A New Route Of Fucoidan Immobilization On Low Density Polyethylene And Its Blood Compatibility And Anticoagulation Activity A Novel Rutin-Fucoidan Complex Based Phytotherapy For Cervical Cancer Through Achieving Enhanced Bioavailability And Cancer Cell Apoptosis A Promising Oral Fucoidan-Based Antithrombotic Nanosystem: Development, Activity And Safety A Quantitative Method To Detect Fucoidan In Human Plasma Using A Novel Antibody. A Randomized Placebo-Controlled Trial Of An Oral Preparation Of High Molecular Weight Fucoidan In Patients With Type 2 Diabetes With Evaluation Of Taste Sensitivity A Review About The Development Of Fucoidan In Antitumor Activity: Progress And Challenges A Review Of The Usability Of Fucoidan Extracted From Brown Seaweed As A Functional Ingredient Of Cosmetics A Revised Structure For Fucoidan May Explain Some Of Its Biological Activities. A Study Of Fucoidan From The Brown Seaweed Chorda Filum A Study On The Anticoagulant And Fibrinolytic Activities Of A Crude Fucoidan From The Edible Brown Seaweed Laminaria Religiosa, With Special Reference To Its Inhibitory … A Sulfated Polysaccharide, Fucoidan, Enhances The Immunomodulatory Effects Of Lactic Acid Bacteria A001 Affinity Of Low Molecular Weight Fucoidan For P-Selectin Triggers Its Binding To Activated Human Platelets Ability Of Fucoidan To Prevent Muscle Necrosis Induced By Snake Venom Myotoxins: Comparison Of High-And Low-Molecular Weight Fractions Abstract A47: Fucoidan From Laminaria Cichorioides Inhibits Ap‐1 Transactivation And Cell Transformation In Mouse Epidermal Jb6 Cells Accumulation Of Fibronectin In Articular Cartilage Explants Cultured With Tgfβ1 And Fucoidan Acid-Promoted Synthesis Of Per-O-Sulfated Fucooligosaccharides Related To Fucoidan Fragments Activation Of Caspase-8 Contributes To Fucoidan-Induced Apoptosis In Ht-29 Human Colon Cancer Cells Activation Of Nk
A Role For Somatostatin In The Impaired insulin Secretory Response To glucose By Islets From Aging Rats A Study Of The Effect Of Aging On insulin And Glueagon Release During Intravenous glucose Tolerance Test Ability Of insulin To Modulate Hepatic glucose Production In Aging Rats Is Impaired By Fat Accumulation Accumulation Of Advanced glycation Endproducts In Aging Male Fischer 344 Rats During Long-Term Feeding Of Various Dietary carbohydrate s Adrenergic And Cholinergic Mediated glucose Oxidation By Rat Parotid Gland Acinar Cells During Aging Ageloc Vitality Improves Endurance Exercise, Exercise glucose Metabolism And Antioxidant Capacity In An Aging Model Aging Alters glucose Uptake In The Naïve And Injured Rodent Spinal Cord Aging Alters The Circadian Rhythm Of glucose Utilization In The Suprachiasmatic Nucleus Aging And cancer : Is glucose A Mediator Between Them? Aging And glucose Homeostasis In C57Bl/6J Male Mice. Aging And glucose Transporter Plasticity In Response To Hypobaric Hypoxia Aging And High Concentrations Of glucose Potentiate Injury To Mitochondrial Dna Aging And Ovariectomy Cause A Decrease In Brain glucose Consumption In Vivo In Wistar Rats Aging And Presbycusis: Effects On 2-Deoxy-D-Glucose Uptake In The Mouse Auditory Brain Stem In Quiet Aging And The Disposition Of glucose Aging Changes Tissue-Specific glucose Metabolism In Rats Aging Does Not Aggravate The Pregnancy-Induced Adaptations In glucose Tolerance In Rats Aging Exaggerates glucose Intolerance Following Injury. Aging Impairs Insulin-Stimulated glucose Uptake In Rat Skeletal Muscle Via Suppressing Ampkα Aging In Vitro And D‐Glucose Uptake Kinetics Of Diploid Human Fibroblasts Aging Increases Susceptibility To Western Diet-Induced glucose Intolerance And insulin Resistance In Mice Aging Is Associated With Increased Hba1C Levels, Independently Of glucose Levels And insulin Resistance, And Also With Decreased Hba1C Diagnostic Specificity Aging Is Associated With Increased Susceptibility To Western Diet-Induced glucose Intolerance And Endothelial Dysfunction In Mice Aging Of Membrane Transport Mechanisms In The Central Nervous System—2-Deoxy-D-Glucose Transport In Cortical Synaptosomes From The Long-Evans Rat Aging Of Proteins And Nucleic Acids: What Is The Role Of glucose ? Aging Of Proteins: Immunological Detection Of A glucose -Derived Pyrrole Formed During Maillard Reaction In Vivo. Aging Of Proteins: Isolation And Identification Of A Fluorescent Chromophore From The Reaction Of Polypeptides With glucose Aging Per Se Does Not Influence glucose Homeostasis: In Vivo And In Vitro Evidence Aging Per Se Does Not Influence Postprandial glucose Levels In Type 2 diabetes Aging , Acute Oxidative Injury And Hepatocellular glucose Transport In The Rat Aging , glucose Metabolism, And diabetes : Current Concepts. Aging , Vascular Risk, And Cognition: Blood glucose , Pulse Pressure, And cognitive Performance In Healthy Adults. Aging : Drugs To Eliminate Methylglyoxal, A Reactive glucose Metabolite, And Advanced glycation Endproducts Aging -Related Changes Of Inorganic Compound Leaching And carbohydrate s In Pyracantha Angustifolia Seeds Aging -Related Correlation Of Insulin-Degrading Enzyme With Γ-Secretase-Generated Products Involving insulin And glucose Levels In Transgenic Mice Alterations In The Ultradian Oscillations Of insulin Secretion And Plasma glucose In Aging Alterations Of Band 3 Transport Protein By Cellular Aging And Disease: Erythrocyte Band 3 And glucose Transporter