THERMO

INTERSTELLAR BLEND “THERMO”

The Ultimate Fat Burning Formula & Glucose Disposal Agent

300 1/8 teaspoon servings per bag

​DOSAGE:

A little more frequent is more effective than a lot all at once.

Start with 1/8 teaspoon in 2-4 oz of hot water

every 4-6 hours and adjust accordingly.

For OPTIMUM RESULTS to preserve muscle and burn fat take 1/8 to 1/4 teaspoon PREWORKOUT in FASTED STATE 

• BENEFITS INCLUDE:
• ​GLUCONEOGENESIS INHIBITION. (STOPS MUSCLES FROM BEING ROBBED OF THEIR AMINO ACIDS TO PRODUCE GLUCOSE)
• INCREASED INSULIN SENSITIVITY THROUGH INSULIN MIMETICS AND INSULIN SENSITIZERS.
• ENHANCED SHUTTLING OF GLUCOSE INTO MUSCLES.
• LOWERED AND REGULATED BLOOD SUGAR.
• TARGETED REMOVAL OF STUBBORN SUBCUTANEOUS AND VISCERAL FAT.
• EFFICIENTLY DETERRING INSULIN RESISTANT INDUCED NEW FAT STORAGE.
• ENHANCED MENTAL FOCUS, ENERGY AND CLARITY.
• AMPK ACTIVATION.
• MTOR INHIBITION.
• DIABETIC AND PREDIABETIC PROTECTION WHEN COMBINED WITH LOW GLYCEMIC LOAD DIET. ​

​​Click on links below to in depth learn about each of the ingredients in this amazing one of a kind blend!  Test your blood sugar before and after and see for yourself!

Coriolus Versicolor (Turkey Tail Mushroom)

1. Macrophage-Stimulating Activity of Polysaccharides Extracted from Fruiting Bodies of Coriolus versicolor (Turkey Tail Mushroom)
2. Beta‐glucans in higher fungi and their health effects
3. A review of research on the protein-bound polysaccharide (polysaccharopeptide, PSP) from the mushroom Coriolus versicolor (Basidiomycetes: Polyporaceae)
4. Coriolus versicolor polysaccharide peptide slows progression of advanced non-small cell lung cancer
5. Polysaccharopeptides of Coriolus versicolor: physiological activity, uses, and production
6. Antitumor effects of a refined polysaccharide peptide fraction isolated from Coriolus versicolor: in vitro and in vivo studies
7. Separation, purification, and α-glucosidase inhibition of polysaccharides from Coriolus versicolor LH1 mycelia
8. Hypoglycemic effects of exo-biopolymers produced by five different medicinal mushrooms in STZ-induced diabetic rats
9. In vitro chemopreventive effects of plant polysaccharides (Aloe barbadensis Miller, Lentinus edodes, Ganoderma lucidum and Coriolus versicolor)
10. Anti-tumor effect of Coriolus versicolor methanol extract against mouse B16 melanoma cells: in vitro and in vivo study

Mirabilis Jalapa (Ursolic Acid)

1. Hypoglycemic and hypolipidemic effects of ethanolic extract of Mirabilis jalapa L. root on normal and diabetic mice
2. Experimental diabetes treated with trigonelline: effect on β cell and pancreatic oxidative parameters
3. Study on Hypoglycemic Effect of Mirabilis jalapa on Adrenergic Model Mice [J]
4. Antiviral and Antiviroid Activity of MAP-Containing Extracts from Mirabilis jalapa Roots
5. Antinociceptive activity of Mirabilis jalapa in mice
6. In-vitro antioxidant potential of methanolic extracts of Mirabilis jalapa Linn
7. Biochemical analysis of Cassia fistula aqueous extract and phytochemically synthesized gold nanoparticles as hypoglycemic treatment for diabetes mellitus
8. GC/MS and LC/MS analysis, and antioxidant and antimicrobial activities of various solvent extracts from Mirabilis jalapa tubers
9. Antinociceptive effect of Mirabilis jalapa on acute and chronic pain models in mice
10. Pharmacological study of antispasmodic activity of Mirabilis jalapa Linn flowers

Ocimum Sanctum (Holy Basil)

1. Evaluation of antioxidant and wound healing effects of alcoholic and aqueous extract of Ocimum sanctum Linn in rats
2. Antioxidant activity and lipid-lowering effect of essential oils extracted from Ocimum sanctum L. leaves in rats fed with a high cholesterol diet
3. Antidiabetic effects of the different fractions of ethanolic extracts of Ocimum sanctum in normal and alloxan induced diabetic rats
4. Hypoglycemic effect of Ocimum sanctum leaf extract in normal and streptozotocin diabetic rats.
5. Ethanolic extract of Ocimum sanctum leaves partially attenuates streptozotocin-induced alterations in glycogen content and carbohydrate metabolism in rats
6. Effect of Ocimum sanctum leaf powder on blood lipoproteins, glycated proteins and total amino acids in patients with non-insulin-dependent diabetes mellitus
7. Ocimum sanctum leaf extracts stimulate insulin secretion from perfused pancreas, isolated islets and clonal pancreatic β-cells
8. Antidiabetic, antihypercholesterolaemic and antioxidant effect of Ocimum sanctum (Linn) seed oil
9. Randomized placebo-controlled, single blind trial of holy basil leaves in patients with noninsulin-dependent diabetes mellitus.
10. Evaluation of hypoglycemic and antioxidant effect ofOcimum sanctum

Naringenin

1. Naringenin prevents obesity, hepatic steatosis, and glucose intolerance in male mice independent of fibroblast growth factor 21
2. Naringenin prevents dyslipidemia, apolipoprotein B overproduction, and hyperinsulinemia in LDL receptor–null mice with diet-induced insulin resistance
3. Naringenin suppresses macrophage infiltration into adipose tissue in an early phase of high-fat diet-induced obesity
4. DNA-protective effects of quercetin or naringenin in alloxan-induced diabetic mice
5. Anti-inflammatory and antifibrotic effects of naringenin in diabetic mice
6. Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes
7. Antihyperglycemic and antioxidant effects of a flavanone, naringenin, in streptozotocin–nicotinamide-induced experimental diabetic rats
8. Participation of antioxidant and cholinergic system in protective effect of naringenin against type-2 diabetes-induced memory dysfunction in rats
9. Effect of citrus flavonoids on lipid metabolism and glucose-regulating enzyme mRNA levels in type-2 diabetic mice
10. Inhibition of microsomal triglyceride transfer protein expression and apolipoprotein B100 secretion by the citrus flavonoid naringenin and by insulin involves activation

Oroxylum Indicum (Indian trumpet flower)

1. Oroxylin A, a constituent of Oroxylum indicum inhibits adipogenesis and induces apoptosis in 3T3-L1 cells
2. Modulation of liver function, antioxidant responses, insulin resistance and glucose transport by Oroxylum indicum stem bark in STZ induced diabetic rats
3. Screening of six Ayurvedic medicinal plants for anti-obesity potential: An investigation on bioactive constituents from Oroxylum indicum (L.) Kurz bark
4. Oroxylum indicum (L.) Kurz, an important Asian traditional medicine: from traditional uses to scientific data for its commercial exploitation
5. Investigation of the anti-inflammatory and analgesic activities of ethanol extract of stem bark of Sonapatha Oroxylum indicum in vivo
6. Oroxin A from Oroxylum indicum prevents the progression from prediabetes to diabetes in streptozotocin and high-fat diet induced mice
7. Evaluation of antidiabetic and nephroprotective activity of Oroxylum indicum L Kurz and Quercus infectoria G Olivier
8. Protective effect of aqueous extract of Oroxylum indicum Linn.(root bark) against DNBS-induced colitis in rats
9. Antimicrobial and antiinflammatory activities of extracts and constituents of Oroxylum indicum (L.) Vent
10. In vitro antioxidant activity from leaves of Oroxylum indicum (L.) Vent.-A North Indian highly threatened and vulnerable medicinal plant

Rauwolfia Serpentina(Indian Snakeroot)

1. On the use of Rauwolfia serpentina in high blood pressure
2. Methanolic root extract of Rauwolfia serpentina benth improves the glycemic, antiatherogenic, and cardioprotective indices in alloxan-induced diabetic mice
3. Hypertension Treated with Rauwolfia canescens A Comparison with Rauwolfia serpentina
4. Hypoglycaemic and hypolipidemic activities of Rauwolfia serpentina in alloxan-induced diabetic rats.
5. A clinical trial of Rauwolfia serpentina in essential hypertension
6. Phytochemical based strategies for pathogen control and antioxidant capacities of Rauwolfia serpentina extracts
7. Methanolic root extract of Rauwolfia serpentina improves the glucose tolerance in wister mice
8. Rauwolfia serpentina in the treatment of high blood pressure: a review of the literature
9. Prospecting for novel plant-derived molecules of Rauvolfia serpentina as inhibitors of Aldose Reductase, a potent drug target for diabetes
10. Rauwolfia serpentina in essential hypertension

Capsaicin

1. Obesity and thermogenesis related to the consumption of caffeine, ephedrine, capsaicin, and green tea
2. Effects of capsaicin-containing yellow curry sauce on sympathetic nervous system activity and diet-induced thermogenesis in lean and obese young women
3. Dietary capsaicin reduces obesity‐induced insulin resistance and hepatic steatosis in obese mice fed a high‐fat diet
4. Effect of treatment with capsaicin on daily activities of patients with painful diabetic neuropathy
5. Treatment of painful diabetic neuropathy with topical capsaicin. A multicenter, double-blind, vehicle-controlled study
6. Topical capsaicin in painful diabetic neuropathy: effect on sensory function
7. Topical capsaicin in painful diabetic neuropathy: controlled study with long-term follow-up
8. The effect of cannabinoids on capsaicin-evoked calcitonin gene-related peptide (CGRP) release from the isolated paw skin of diabetic and non-diabetic rats
9. A double-blind comparison of topical capsaicin and oral amitriptyline in painful diabetic neuropathy.
10. Influence of dietary capsaicin and onion on the metabolic abnormalities associated with streptozotocin induced diabetes mellitus

Gynostemma  (The Herb of Immortality)

1. Anti-hyperlipidemic and hypoglycemic effects of Gynostemma pentaphyllum in the Zucker fatty rat
2. Antiobesity effect of Gynostemma pentaphyllum extract (actiponin): A randomized, double‐blind, placebo‐controlled trial
3. Potential Hypoglycemic Effect of an Ethanol Extract of Gynostemma pentaphyllum in C57BL/KsJ-db/db Mice
4. Antidiabetic effect of Gynostemma pentaphyllum tea in randomly assigned type 2 diabetic patients
5. Antidiabetic effects of add-on Gynostemma pentaphyllum extract therapy with sulfonylureas in type 2 diabetic patients
6. Gynostemma pentaphyllum Tea Improves Insulin Sensitivity in Type 2 Diabetic Patients
7. A novel insulin-releasing substance, phanoside, from the plant Gynostemma pentaphyllum
8. Hypoglycemic effect of Gynostemma pentaphyllum saponins by enhancing the Nrf2 signaling pathway in STZ-inducing diabetic rats
9. Heat-processed Gynostemma pentaphyllum extract improves obesity in ob/ob mice by activating AMP-activated protein kinase
10. Effects of obesity on functional capacity

Rosa Canina (Trans-Tiliroside)

1. Potent anti-obese principle from Rosa canina: structural requirements and mode of action of trans-tiliroside
2. Effects of rose hip intake on risk markers of type 2 diabetes and cardiovascular disease: a randomized, double-blind, cross-over investigation in obese
3. Rosehip extract inhibits lipid accumulation in white adipose tissue by suppressing the expression of peroxisome proliferator-activated receptor gamma
4. Antidiabetic effect and antioxidant potential of Rosa canina fruits
5. In vivo anti-inflammatory and antinociceptive activity of the crude extract and fractions from Rosa canina L. fruits
6. Rosa canina extracts have antiproliferative and antioxidant effects on caco-2 human colon cancer
7. Effects of Rosa canina L. fruit on glycemia and lipid profile in type 2 diabetic patients: a randomized, double-blind, placebo-controlled clinical trial
8. Rose hip exerts antidiabetic effects via a mechanism involving downregulation of the hepatic lipogenic program
9. Anti‐prediabetic effect of rose hip (Rosa canina) extract in spontaneously diabetic Torii rats
10. Rosehip: an evidence based herbal medicine for inflammation and arthritis

Galega Officinalis (botanical version of Metformin)

1. Novel weight‐reducing activity of Galega officinalis in mice
2. A systematic review of the efficacy and safety of herbal medicines used in the treatment of obesity
3. Administration of Galega officinalis in experimental and clinical investigations; a narrative review
4. Alleviation of salt stress of symbiotic Galega officinalis L. (goat’s rue) by co-inoculation of Rhizobium with root-colonizing Pseudomonas
5. Natural products in anti-obesity therapy
6. Effect of Fabaceae (Galega Officinalis L.) consumption on levels of blood glucose, lipids and lipoproteins in streptozotocin-induced diabetic rats
7. Anti-diabetic potential and Indian medicinal plants
8. Antiplatelet Aggregation Activity of a Fraction Isolated from Galega officinalis L.
9. The alkaloid-free fraction from Galega Officinalis extract prevents oxidative stress under experimental diabetes mellitus
10. Cytotoxic, anti-inflammatory and antioxidant activities of four different extracts of Galega officinalis L (Goat’s rue)

EGCG (green tea extract)

1. Recent findings of green tea extract AR25 (Exolise) and its activity for the treatment of obesity
2. Effect of green tea extract on obese women: a randomized, double-blind, placebo-controlled clinical trial
3. Efficacy of a green tea extract rich in catechin polyphenols and caffeine in increasing 24-h energy expenditure and fat oxidation in humans
4. Effects of green tea and EGCG on cardiovascular and metabolic health
5. Assessment of DNA damage and lipid peroxidation in diabetic mice: effects of propolis and epigallocatechin gallate (EGCG)
6. Epigallocatechin gallate (EGCG) attenuates high glucose‐induced insulin signaling blockade in human hepG2 hepatoma cells
7. Effect of green tea on blood glucose levels and serum proteomic patterns in diabetic (db/db) mice and on glucose metabolism in healthy humans
8. Epigallocatechin-3-O-gallate (EGCG) protects the insulin sensitivity in rat L6 muscle cells exposed to dexamethasone condition
9. Protective effects of epigallocatechin gallate (EGCG) on streptozotocin-induced diabetic nephropathy in mice
10. Effects of oral consumption of the green tea polyphenol EGCG in a murine model for human Sjogren’s syndrome, an autoimmune disease

Resveratrol (Giant Knot Weed)

1. Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans
2. Resveratrol exerts anti-obesity effects via mechanisms involving down-regulation of adipogenic and inflammatory processes in mice
3. Long-term resveratrol administration reduces metabolic disturbances and lowers blood pressure in obese Zucker rats
4. Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients
5. Resveratrol, a red wine antioxidant, possesses an insulin-like effect in streptozotocin-induced diabetic rats
6. AMP-activated protein kinase–deficient mice are resistant to the metabolic effects of resveratrol
7. Effect of insulin and its combination with resveratrol or curcumin in attenuation of diabetic neuropathic pain: participation of nitric oxide and TNF‐alpha
8. Resveratrol alleviates cardiac dysfunction in streptozotocin-induced diabetes: Role of nitric oxide, thioredoxin, and heme oxygenase
9. Anti‐diabetic effects of resveratrol
10. Effects of resveratrol on nerve functions, oxidative stress and DNA fragmentation in experimental diabetic neuropathy

Ashwaghanda

1. Effects of Withania somnifera (Ashwagandha) and Terminalia arjuna (Arjuna) on physical performance and cardiorespiratory endurance in healthy young
2. Effect of Ashwagandha (Withania somnifera) Root Powder Supplementation in Treatment of Hypertension
3. Body weight management in adults under chronic stress through treatment with Ashwagandha root extract: a double-blind, randomized, placebo-controlled trial
4. Hypoglycaemic and hypolipidaemic effects of Withania somnifera root and leaf extracts on alloxan-induced diabetic rats
5. Effect of dietary intake ashwagandha roots powder on the levels of sex hormones in the diabetic and non-diabetic male rats
6. Effect of Withania somnifera on Insulin Sensitivity in Non‐Insulin‐Dependent Diabetes Mellitus Rats
7. Effect of withania somnifera on levels of sex hormones in the diabetic male rats
8. The effect of chronic oral administration of Withania somnifera root on learning and memory in diabetic rats using passive avoidance test
9. Reverse Ayurvedic pharmacology of Ashwagandha as an adaptogenic anti-diabetic plant: a pilot study
10. The effect of oral administration of Withania somnifera root on formalin-induced pain in diabetic rats

Turmeric (curcumin)

1. Effects of ingested turmeric oleoresin on glucose and lipid metabolisms in obese diabetic mice: a DNA microarray study
2. Effects of fermented turmeric extracts on the obesity in rats fed a high-fat diet
3. Curcumin inhibits adipogenesis in 3T3-L1 adipocytes and angiogenesis and obesity in C57/BL mice
4. Modulatory effects of garlic, ginger, turmeric and their mixture on hyperglycaemia, dyslipidaemia and oxidative stress in streptozotocin–nicotinamide diabetic rats
5. Curcumin, the active principle of turmeric (Curcuma longa), ameliorates diabetic nephropathy in rats
6. Curcuminoids and Sesquiterpenoids in Turmeric (Curcuma longa L.) Suppress an Increase in Blood Glucose Level in Type 2 Diabetic KK-Ay Mice
7. Hypolipidemic action of curcumin, the active principle of turmeric (Curcuma longa) in streptozotocin induced diabetic rats
8. Efficacy of turmeric on blood sugar and polyol pathway in diabetic albino rats
9. Effect of turmeric and curcumin on oxidative stress and antioxidant enzymes in streptozotocin-induced diabetic rat
10. Curcumin and turmeric delay streptozotocin-induced diabetic cataract in rats

Bioperine

1. Effect of piperine in the regulation of obesity-induced dyslipidemia in high-fat diet rats
2. Piperine, an active principle from Piper nigrum, modulates hormonal and apolipoprotein profiles in hyperlipidemic rats
3. LIPID‐LOWERING EFFICACY OF PIPERINE FROM PIPER NIGRUM L. IN HIGH‐FAT DIET AND ANTITHYROID DRUG‐INDUCED HYPERCHOLESTEROLEMIC
4. Effects of piperine on antioxidant pathways in tissues from normal and streptozotocin‐induced diabetic rats
5. Evaluation of the effect of piperine per se on blood glucose level in alloxan-induced diabetic mice
6. Antioxidant and anti-inflammatory effects of curcuminoid-piperine combination in subjects with metabolic syndrome
7. Piperine, a natural bioenhancer, nullifies the antidiabetic and antioxidant activities of curcumin in streptozotocin-diabetic rats
8. Protective effect of piperine on benzo (a) pyrene-induced lung carcinogenesis in Swiss albino mice
9. Piperine reverses high fat diet-induced hepatic steatosis and insulin resistance in mice
10. Effects of curcuminoids-piperine combination on systemic oxidative stress, clinical symptoms

Berberine

1. Effects and action mechanisms of berberine and Rhizoma coptidis on gut microbes and obesity in high-fat diet-fed C57BL/6J mice
2. Structural changes of gut microbiota during berberine-mediated prevention of obesity and insulin resistance in high-fat diet-fed rats
3. Berberine improves lipid dysregulation in obesity by controlling central and peripheral AMPK activity
4. Lipid-lowering effect of berberine in human subjects and rats
5. Berberine inhibits adipogenesis in high-fat diet-induced obesity mice
6. Berberine suppresses proinflammatory responses through AMPK activation in macrophages
7. Modulating gut microbiota as an anti-diabetic mechanism of berberine
8. Berberine improves glucose metabolism through induction of glycolysis
9. Insulin sensitizing and insulinotropic action of berberine from Cortidis rhizoma
10. Anti-diabetic effects of cinnamaldehyde and berberine and their impacts on retinol-binding protein 4 expression in rats with type 2 diabetes mellitus

Pausinystalia Johimbe (stubborn fat alpha blocker)

1. Plasma catecholamine levels and lipid mobilization induced by yohimbine in obese and non-obese women.
2. Cardiovascular effects of ephedrine, caffeine and yohimbine measured by thoracic electrical bioimpedance in obese women
3. Yohimbine: the effects on body composition and exercise performance in soccer players
4. Yohimbe Alkaloids–General Discussion
5. The histological effects of mixed diet containing Pausinystalia yohimbe ground stem bark on the kidney of adult Wistar rats (Rattus norvegicus)
6. Noradrenergic function in generalized anxiety disorder: effects of yohimbine in healthy subjects and patients with generalized anxiety disorder
7. Yohimbine for erectile dysfunction: a systematic review and meta-analysis of randomized clinical trials
8. Cameroonian medicinal plants: pharmacology and derived natural products
9. Effects of methanolic extract of Pausinystalia yohimbe bark on blood glucose level in normal fasting rats
10. Effects of methanolic extract of yohimbe bark (Pausinystalia yohimbe) on isolated rabbit aortic strip and rat uterus

Green Coffee Bean Extract (Chlorogenic Acid)

1. The effect of chlorogenic acid enriched coffee on glucose absorption in healthy volunteers and its effect on body mass when used long-term in overweight and obese
2. Chlorogenic acid exhibits anti-obesity property and improves lipid metabolism in high-fat diet-induced-obese mice
3. Chlorogenic acid modifies plasma and liver concentrations of: cholesterol, triacylglycerol, and minerals in (fa/fa) Zucker rats
4. Coffee acutely modifies gastrointestinal hormone secretion and glucose tolerance in humans: glycemic effects of chlorogenic acid and caffeine
5. Acute effects of decaffeinated coffee and the major coffee components chlorogenic acid and trigonelline on glucose tolerance
6. A chlorogenic acid-induced increase in GLP-1 production may mediate the impact of heavy coffee consumption on diabetes risk
7. Chlorogenic acid stimulates glucose transport in skeletal muscle via AMPK activation: a contributor to the beneficial effects of coffee on diabetes
8. Anti-diabetic and anti-lipidemic effects of chlorogenic acid are mediated by ampk activation
9. Coffee consumption and risk of type 2 diabetes mellitus
10. Chlorogenic acid and rutin play a major role in the in vivo anti-diabetic activity of Morus alba leaf extract on type II diabetic rats

Forskolin (Coleus forskohlii)

1. Body composition and hormonal adaptations associated with forskolin consumption in overweight and obese men
2. The antihypertensive and positive inotropic diterpene forskolin: effects of structural modifications on its activity
3. Antagonism of forskolin effects by adenosine in isolated hearts and ventricular myocytes
4. Effect of chronic administration of forskolin on glycemia and oxidative stress in rats with and without experimental diabetes
5. Insulin and glucagon releasing activity of coleonol (forskolin) and its effect on blood glucose level in normal and alloxan diabetic rats
6. Insulin biosynthesis in HIT cells: effects of glucose, forskolin, IBMX, and dexamethasone
7. Direct anesthetic-like effects of forskolin on the nicotinic acetylcholine receptors of PC12 cells.
8. The ionic, electrical, and secretory effects of endogenous cyclic adenosine monophosphate in mouse pancreatic B cells: studies with forskolin
9. The effects of forskolin and rolipram on cAMP, cGMP and free fatty acid levels in diet induced obesity
10. Forskolin effects on the voltage-gated K+ conductance of human T cells

NADH

1. Pharmacological stimulation of NADH oxidation ameliorates obesity and related phenotypes in mice
2. Regulation of leaf senescence by cytokinin, sugars, and light: effects on NADH-dependent hydroxypyruvate reductase
3. Therapeutic effects of oral NADH on the symptoms of patients with chronic fatigue syndrome
4. Effects of cytosolic NADH/NAD+ levels on sarcoplasmic reticulum Ca2+ release in permeabilized rat ventricular myocytes
5. Effects of glucose and PaO2 modulation on cortical intracellular acidosis, NADH redox state, and infarction in the ischemic penumbra
6. Low-potential stable NADH detection at carbon-nanotube-modified glassy carbon electrodes
7. Effects of NADH and NADPH on superoxide levels and cerebral vascular tone
8. Kinetic experiments on the synergistic effect of NADH on microsomal drug oxidation
9. Effects of base on oxidation of an NADH model compound by iron (III) complexes and tetracyanoethylene
10. Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain

Nigella Sativa  (Black Cumin)

1. Efficacy of Nigella sativa on serum free testosterone and metabolic disturbances in central obese male.
2. Multiple molecular targets underlie the antidiabetic effect of Nigella sativa seed extract in skeletal muscle, adipocyte and liver cells
3. Antihypertensive effect of Nigella sativa seed extract in patients with mild hypertension
4. Effect of Nigella sativa on glucose concentration, lipid peroxidation, anti‐oxidant defence system and liver damage in experimentally‐induced diabetic rabbits
5. Hypoglycemic effects of the volatile oil of Nigella sativa seeds
6. Effects of Nigella sativa on oxidative stress and β‐cell damage in streptozotocin‐induced diabetic rats
7. Biochemical effects of Nigella sativa L seeds in diabetic rats
8. Mechanisms of the hypoglycaemic and immunopotentiating effects of Nigella sativa L. oil in streptozotocin-induced diabetic hamsters
9. Isulinotropic properties of Nigella sativa oil in Streptozotocin plus Nicotinamide diabetic hamster
10. Partial regeneration/proliferation of the β-cells in the Islets of Langerhans by Nigella sativa L. in streptozotocin-induced diabetic rats

Hoodia Gordonii (Queen of the Namib)

1. Effects of 15-d repeated consumption of Hoodia gordonii purified extract on safety, ad libitum energy intake, and body weight in healthy, overweight women
2. Hoodia gordonii in the treatment of obesity: A review
3. Metabolic effect of short term administration of Hoodia gordonii, an herbal appetite suppressant
4. Hoodia gordonii: a natural appetite suppressant
5. Indigenous use of Hoodia gordonii and appetite suppression
6. Complementary and alternative medicine for the treatment of obesity: a critical review
7. Sympathomimetic activity of a Hoodia gordonii product: a possible mechanism of cardiovascular side effects
8. Hoodia gordonii extract targets both adipose and muscle tissue to achieve weight loss in rats
9. Metabolic response of short term calorie restriction and supplementation with Hoodia gordonii
10. In vitro transport of the steroidal glycoside P57 from Hoodia gordonii across excised porcine intestinal and buccal tissue

Fucoxanthin

1. Fucoxanthin from edible seaweed, Undaria pinnatifida, shows antiobesity effect through UCP1 expression in white adipose tissues
2. Anti-obesity and anti-diabetic effects of fucoxanthin on diet-induced obesity conditions in a murine model
3. Effect of medium-chain triacylglycerols on anti-obesity effect of fucoxanthin
4. Fucoxanthin and its metabolite, fucoxanthinol, suppress adipocyte differentiation in 3T3-L1 cells
5. Dietary Combination of Fucoxanthin and Fish Oil Attenuates the Weight Gain of White Adipose Tissue and Decreases Blood Glucose in Obese/Diabetic KK-Ay Mice
6. Anti‐obese property of fucoxanthin is partly mediated by altering lipid‐regulating enzymes and uncoupling proteins of visceral adipose tissue in mice
7. Fucoxanthin regulates adipocytokine mRNA expression in white adipose tissue of diabetic/obese KK-Ay mice
8. Fucoxanthin and fucoxanthinol enhance the amount of docosahexaenoic acid in the liver of KKAy obese/diabetic mice
9. Effects of dietary fucoxanthin on cholesterol metabolism in diabetic/obese KK-A y mice
10. The carotenoid fucoxanthin from brown seaweed affects obesity

Bitter Melon(momordica charantia)

1. Effects of Momordica charantia on insulin resistance and visceral obesity in mice on high-fat diet
2. Antihyperglycemic effects of three extracts from Momordica charantia
3. The effect of Momordica charantia and Mucuna pruriens in experimental diabetes and their effect on key metabolic enzymes involved in carbohydrate metabolism
4. Bitter melon (Momordica charantia L.) inhibits adipocyte hypertrophy and down regulates lipogenic gene expression in adipose tissue of diet-induced obese rats
5. Effects of Momordica charantia powder on serum glucose levels and various lipid parameters in rats fed with cholesterol-free and cholesterol-enriched diets
6. Anti-diabetic and hypoglycaemic effects of Momordica charantia (bitter melon): a mini review
7. Inhibition of increases in blood glucose and serum neutral fat by Momordica charantia saponin fraction
8. An experimental evaluation of the antidiabetic and antilipidemic properties of a standardized Momordica charantia fruit extract
9. The insulin-releasing activity of the tropical plant momordica charantia.
10. Antidiabetic Potentials of Momordica charantia: Multiple Mechanisms Behind the Effects

Banaba Leaf  (Lagerstroemia speciosa)

1. Antiobesity activity of extracts from Lagerstroemia speciosa L. leaves on female KK-Ay mice
2. Antidiabetes and anti-obesity activity of Lagerstroemia speciosa
3. Hypoglycemic activity of Lagerstroemia speciosa L. extract on streptozotocin-induced diabetic rat: Underlying mechanism of action
4. An extract of Lagerstroemia speciosa L. has insulin-like glucose uptake–stimulatory and adipocyte differentiation–inhibitory activities in 3T3-L1 cells
5. Antidiabetic activity of a standardized extract (Glucosol™) from Lagerstroemia speciosa leaves in type II diabetics: A dose-dependence study
6. Active Compounds from Lagerstroemia speciosa, Insulin-like Glucose Uptake-Stimulatory/Inhibitory and Adipocyte Differentiation-Inhibitory Activities in 3T3-L1 Cells
7. Hypoglycemic effect of Lagerstroemia speciosa (L.) Pers. on alloxan-induced diabetic mice
8. The hypoglycemic effect of water extract from leaves of Lagerstroemia speciosa L. in streptozotocin-induced diabetic rats.
9. Lagerstroemia speciosa extract inhibit TNF-induced activation of nuclear factor-κB in rat cardiomyocyte H9c2 cells
10. Hypoglycemic effect of extracts from Lagerstroemia speciosa L. leaves in genetically diabetic KK-AY mice

Gymnema Sylvestre (Miracle Fruit)

1. Antihyperglycemic Effects of Gymnemic Acid IV, a Compound Derived from Gymnema sylvestre Leaves in Streptozotocin-Diabetic Mice
2. Comparative effects of chromium, vanadium and Gymnema sylvestre on sugar-induced blood pressure elevations in SHR
3. Evaluation of antiobesity and cardioprotective effect of Gymnema sylvestre extract in murine model
4. Antidiabetic effect of a leaf extract from Gymnema sylvestre in non-insulin-dependent diabetes mellitus patients
5. Possible regeneration of the islets of Langerhans in streptozotocin-diabetic rats given Gymnema sylvestre leaf extracts
6. Use of Gymnema sylvestre leaf extract in the control of blood glucose in insulin-dependent diabetes mellitus
7. Gymnema sylvestre stimulates insulin release in vitro by increased membrane permeability
8. Enzyme changes and glucose utilisation in diabetic rabbits: the effect of Gymnema sylvestre, R. Br.
9. Antidiabetic and hypolipidemic activity of Gymnema sylvestre in alloxan induced diabetic rats
10. In vitro callus and in vivo leaf extract of Gymnema sylvestre stimulate β-cells regeneration and anti-diabetic activity in Wistar rats

R-ALA (r-Alpha-Lipoic acid)

1. Effects of exercise training and antioxidant R-ALA on glucose transport in insulin-sensitive rat skeletal muscle
2. Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential
3. α-Lipoic acid: a multifunctional antioxidant that improves insulin sensitivity in patients with type 2 diabetes
4. Alpha-lipoic acid as a biological antioxidant
5. Antioxidant alpha-lipoic acid: a 7-month multicenter randomized controlled trial (ALADIN III Study). ALADIN III Study Group. Alpha-Lipoic Acid in Diabetic
6. Effects of DL-alpha-lipoic acid on peripheral nerve conduction, blood flow, energy metabolism, and oxidative stress in experimental diabetic neuropathy
7. alpha-Lipoic acid treatment decreases serum lactate and pyruvate concentrations and improves glucose effectiveness in lean and obese patients with type 2 diabetes.
8. Alpha-lipoic acid: antioxidant potency against lipid peroxidation of neural tissues in vitro and implications for diabetic neuropathy
9. Effects of alpha-lipoic acid on microcirculation in patients with peripheral diabetic neuropathy
10. Alpha-lipoic acid: effect on glucose uptake, sorbitol pathway, and energy metabolism in experimental diabetic neuropathy.

Cissus Quadrangularis (Asthisamharaka)

1. The effect of Cissus quadrangularis (CQR-300) and a Cissus formulation (CORE) on obesity and obesity-induced oxidative stress
2. The use of a Cissus quadrangularis/Irvingia gabonensis combination in the management of weight loss: a double-blind placebo-controlled study
3. The use of a Cissus quadrangularis formulation in the management of weight loss and metabolic syndrome
4. Antioxidant and Antimicrobial Activity of Cissus quadrangularis L.
5. Pharmacological actions of Cassia auriculata L. and Cissus quadrangularis Wall: A short review
6. Hypoglycemic and anti-lipemic effects of the aqueous extract from Cissus sicyoides
7. Cissus quadrangularis stem alleviates insulin resistance, oxidative injury and fatty liver disease in rats fed high fat plus fructose diet
8. Beneficial effect of Cissus quadrangularis Linn. on osteopenia associated with streptozotocin-induced type 1 diabetes mellitus in male Wistar rats
9. Evaluation of the antidiabetic and antibacterial activity of Cissus sicyoides
10. Cissus quadrangularis extract attenuates hyperglycaemia-mediated oxidative stress in streptozotocin-induced diabetic rats

Sesamin

1. Effect of sesamin supplementation on cardiovascular risk factors in women with rheumatoid arthritis
2. The sesame lignan sesamin attenuates vascular dysfunction in streptozotocin diabetic rats: involvement of nitric oxide and oxidative stress
3. Sesame oil exhibits synergistic effect with anti-diabetic medication in patients with type 2 diabetes mellitus
4. Antihypertensive effect of sesamin. IV. Inhibition of vascular superoxide production by sesamin
5. Quercetin and sesamin protect neuronal PC12 cells from high-glucose-induced oxidation, nitrosative stress, and apoptosis
6. Effects of vitamin E and sesamin on hypertension and cerebral thrombogenesis in stroke-prone spontaneously hypertensive rats
7. Hypoglycaemic and hypolipidaemic activities of sesamin from sesame meal and its ability to ameliorate insulin resistance in KK‐Ay mice
8. Effects of sesamin on streptozotocin (STZ)-induced NIT-1 pancreatic β-cell damage
9. EFFECTS OF VITAMIN E AND SESAMIN ON HYPERTENSION AND CEREBRAL THROMBOGENESIS IN STROKE‐PRONE SPONTANEOUSLY HYPERTENSIVE
10. Preventive effect of sesame seed cake on hyperglycemia and obesity against high fructose-diet induced Type 2 diabetes in rats

Callophyllis Japonica

1. Callophyllis japonica extract improves high-fat diet-induced obesity and inhibits adipogenesis in 3T3-L1 cells
2. Anti-inflammatory effect of polyphenol-rich extract from the red alga Callophyllis japonica in lipopolysaccharide-induced RAW 264.7 macrophages
3. Anti-obesity effect of Solidago virgaaurea extract in high-fat diet-fed SD rat
4. Antioxidant activity of ethanol extract of Callophyllis japonica
5. Investigation of the antiasthmatic properties of ethanol extract of Callophyllis japonica in mice
6. Antioxidants from macroalgae: potential applications in human health and nutrition
7. The radioprotective effects of the hexane and ethyl acetate extracts of Callophyllis japonica in mice that undergo whole body irradiation
8. Effects of Callophyllis japonica powder on carbon tetrachloride-induced liver injury in rats
9. A comparative study of radioprotection with Callophyllis japonica extract and amifostine against lethal whole body gamma irradiation in mice
10. Immunomodulatory Effects of Callophyllis japonica Ethanol Extract on Dendritic Cells

Tangeritin(Citrus reticulata)

1. Citrus bioactive phenolics: Role in the obesity treatment
2. Citrus aurantium flavonoids inhibit adipogenesis through the Akt signaling pathway in 3T3-L1 cells
3. Tangeretin stimulates glucose uptake via regulation of AMPK signaling pathways in C2C12 myotubes and improves glucose tolerance in high-fat diet-induced obese
4. Effect of tangeretin, a polymethoxylated flavone on glucose metabolism in streptozotocin-induced diabetic rats
5. Regulation of adipocytokine secretion and adipocyte hypertrophy by polymethoxyflavonoids, nobiletin and tangeretin
6. Modulation of HepG2 cell net apolipoprotein B secretion by the citrus polymethoxyflavone, tangeretin
7. Phenolic compositions and antioxidant capacities of Chinese wild mandarin (Citrus reticulata Blanco) fruits
8. Studies on preparation of ready to serve mandarin (Citrus reticulata) diet drink
9. Polymethoxylated, C-and O-glycosyl flavonoids in tangelo (Citrus reticulata× Citrus paradisi) juice and their influence on antioxidant properties
10. Polymethoxyflavonoids tangeretin and nobiletin increase glucose uptake in murine adipocytes

Arctigenin(Burdock Seed)

1. Arctigenin Inhibits Adipogenesis by Inducing AMPK Activation and Reduces Weight Gain in High‐Fat Diet‐Induced Obese Mice
2. Arctigenin protects cultured cortical neurons from glutamate‐induced neurodegeneration by binding to kainate receptor
3. Tumor specific cytotoxicity of arctigenin isolated from herbal plant Arctium lappa L.
4. Arctigenin efficiently enhanced sedentary mice treadmill endurance
5. Comparative pharmacokinetics of arctigenin in normal and type 2 diabetic rats after oral and intravenous administration
6. In vitro anti-inflammatory effects of arctigenin, a lignan from Arctium lappa L., through inhibition on iNOS pathway
7. Immunomodulatory Effect of Arctigenin, a Lignan Compound, on Tumour Necrosis Factor‐α and Nitric Oxide Production, and Lymphocyte Proliferation
8. Therapeutic effect of arctiin and arctigenin in immunocompetent and immunocompromised mice infected with influenza A virus
9. Antiproliferative effect of arctigenin and arctiin
10. Arctigenin, a phenylpropanoid dibenzylbutyrolactone lignan, inhibits MAP kinases and AP-1 activation via potent MKK inhibition: the role in TNF-α inhibition

Citrus Aurantium (Bitter Orange)

1. Metabolic and physiological effects of ingesting extracts of bitter orange, green tea and guarana at rest and during treadmill walking in overweight males
2. Citrus aurantium and synephrine alkaloids in the treatment of overweight and obesity: an update
3. A review of the human clinical studies involving Citrus aurantium (bitter orange) extract and its primary protoalkaloid p-synephrine
4. Increase in the thermic effect of food in women by adrenergic amines extracted from citrus aurantium
5. Citrus aurantium as a thermogenic, weight-reduction replacement for ephedra: an overview.
6. Tissue lipid lowering-effect of a traditional Nigerian anti-diabetic infusion of Rauwolfia vomitoria foilage and Citrus aurantium fruit
7. Effects of Citrus aurantium extract, caffeine, and St. John’s wort on body fat loss, lipid levels, and mood states in overweight healthy adults
8. Thermic effect of Citrus aurantium in obese subjects
9. Anxiolytic and sedative effects of extracts and essential oil from Citrus aurantium L.
10. Antiobesity and cardiovascular toxic effects of Citrus aurantium extracts in the rat: a preliminary report

Pyrroloquinoline Quinone(PQQ) (Natto)

1. Altering pyrroloquinoline quinone nutritional status modulates mitochondrial, lipid, and energy metabolism in rats
2. Pyrroloquinoline quinone (PQQ) producing Escherichia coli Nissle 1917 (EcN) alleviates age associated oxidative stress and hyperlipidemia
3. Pyrroloquinoline quinone stimulates epithelial cell proliferation by activating epidermal growth factor receptor through redox cycling
4. Potential physiological importance of pyrroloquinoline quinone
5. Pyrroloquinoline quinone, a novel protein tyrosine phosphatase 1B inhibitor, activates insulin signaling in C2C12 myotubes and improves impaired glucose
6. Effects of dietary pyrroloquinoline quinone disodium on growth, carcass characteristics, redox status, and mitochondria metabolism in broilers
7. Early PQQ supplementation has persistent long-term protective effects on developmental programming of hepatic lipotoxicity and inflammation in obese mice
8. Pyrroloquinoline quinone ameliorates oxidative stress and lipid peroxidation in the brain of streptozotocin-induced diabetic mice
9. Pyrroloquinoline quinone stimulates mitochondrial biogenesis through CREB phosphorylation and increased PGC-1α expression
10. Pyrroloquinoline quinone prevents developmental programming of microbial dysbiosis and macrophage polarization to attenuate liver fibrosis in offspring of obese

Hesperidin (Citrus Cinsinensis osbeck)

1. The hypoglycemic effects of hesperidin and naringin are partly mediated by hepatic glucose-regulating enzymes in C57BL/KsJ-db/db mice
2. Effects of hesperidin on the progression of hypercholesterolemia and fatty liver induced by high-cholesterol diet in rats
3. Oral intake of a combination of glucosyl hesperidin and caffeine elicits an anti-obesity effect in healthy, moderately obese subjects: a randomized double-blind
4. Chemopreventive effects of diosmin and hesperidin on N‐butyl‐N‐(4‐hydroxybutyl)nitrosamine‐induced urinary‐bladder carcinogenesis in male ICR mice
5. Citrus polyphenol hesperidin stimulates production of nitric oxide in endothelial cells while improving endothelial function and reducing inflammatory markers
6. Dietary hesperidin exerts hypoglycemic and hypolipidemic effects in streptozotocin-induced marginal type 1 diabetic rats
7. Hypoglycemic and hypolipidemic effects of hesperidin and cyclodextrin-clathrated hesperetin in Goto-Kakizaki rats with type 2 diabetes
8. Hesperidin prevents retinal and plasma abnormalities in streptozotocin-induced diabetic rats
9. Antidiabetic effects of hesperidin and naringin in type 2 diabetic rats.
10. Molecular mechanisms behind the biological effects of hesperidin and hesperetin for the prevention of cancer and cardiovascular diseases

Sunifiram

1. DM235 (sunifiram): a novel nootropic with potential as a cognitive enhancer
2. AMPA-receptor activation is involved in the antiamnesic effect of DM 232 (unifiram) and DM 235 (sunifiram)
3. Structure–activity relationship studies on unifiram (DM232) and sunifiram (DM235), two novel and potent cognition enhancing drugs
4. Novel nootropic drug sunifiram improves cognitive deficits via CaM kinase II and protein kinase C activation in olfactory bulbectomized mice
5. Novel nootropic drug sunifiram enhances hippocampal synaptic efficacy via glycine‐binding site of N‐methyl‐D‐aspartate receptor
6. Design, synthesis and preliminary pharmacological evaluation of new analogues of DM232 (unifiram) and DM235 (sunifiram) as cognition modulators
7. Design, synthesis and nootropic activity of new analogues of sunifiram and sapunifiram, two potent cognition-enhancers