Antiproliferative effects of pyrogallol were therefore determined on human tumor cell lines thus identifying pyrogallol as an active component of Emblica officinalis extracts.
Aqueous extract of Emblica officinalis (E.O) was found to be cytotoxic to L 929 cells in culture in a dose dependent manner.
Concentration needed for 50% inhibition of cdc 25 phosphatase was found to be 5 μg/ml and that needed for inhibition of cdc2 kinase was found to be >100 μg/ml. The results suggest that antitumour activity of E.O extract may partially be due to its interaction with cell cycle regulation.
Phyllanthus emblica Linn. (PE) is a medicinal fruit used in many Asian traditional medicine systems for the treatment of various diseases including cancer.
These results suggest P. emblica exhibits anticancer activity against selected cancer cells, and warrants further study as a possible chemopreventive and antiinvasive agent.
Anti-Cancer - Emblica officinalis Gaertn. or Phyllanthus emblica Linn, commonly known as Indian gooseberry or amla, is arguably the most important medicinal plant in the Indian traditional system of medicine, the Ayurveda. Various parts of the plant are used to treat a range of diseases, but the most important is the fruit.
This review for the first time summarizes the results related to these properties and also emphasizes the aspects that warrant future research to establish its activity and utility as a cancer preventive and therapeutic drug in humans.