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    Ginkgo Biloba
    September 13, 2018
    Grape Seed Extract
    September 13, 2018

    Glycyrrhiza Glabra

    Glycyrrhiza Glabra or Licorice root has long been a component as a sweetener in some of our candies and sodas.



    This herb is a type of adaptogen and can be found in many parts of Asia, Europe, Russia and the Mediterranean. It has been used for a variety of conditions such as digestive track issues, heart burn, inflammation.

    The chemicals found within licorice are thought to be an anti inflammatory which decreases the swelling, and increases the chemicals in our body which heal ulcers.

    Benefits of Glycyrrhiza Glabra

    Proliferative Effects - In a screen for naturally occurring angiogenic inhibitors, we have identified an extract from the roots of Glycyrrhiza glabra, which has potent antiangiogenic and antitumor activity.

    Reduction in the levels of the cytokine VEGF and microvessel density count in the peritoneum of mice treated with G. glabra indicated that the plant extract decreased VEGF production and the cytokine induced neovascularization. Our results suggest that the extract from the roots of G. glabra may be a potential supplemental source for cancer therapy.

    (Article)

    Anti-Tumor - Licochalcone (LA) is a novel estrogenic flavonoid isolated from PC-SPES composition herb licorice root that was reported to show significant antitumor activity in various malignant human cell lines.

    These findings provide mechanistic explanation for LA activity and suggest that it may be considered as a chemopreventive agent and its anticancer properties should be further explored.

    (Article)

    Anti-Cancer - The mechanism of growth activation of breast cancer MCF-7 cells, including the activation of Erk1/2 and Akt, and the transcriptional regulation of estrogen-responsive genes, was examined by means of sulforhodamine B, luciferase reporter gene, real-time RT-PCR and Western blotting assays after the induction of the cells with the extract of G. glabra root.

    The results indicate that rapid signaling pathways, including Erk1/2 and Akt, and the subsequent transcriptional regulation are involved in the proliferation of MCF-7 cells induced by the extract of G. glabra root.

    The extract had estrogenic activity and a distinguishable profile of gene expression, suggesting the presence of potentially useful components other than glycyrrhizin in G. glabra root for hormone and anti-cancer therapies.

    (Article)

    A number of pharmaceutical effects of licorice are known or suspected (anti-inflammatory, antivirus, antiulcer, anticarcinogenesis, and others). Licorice and its derivatives may protect against carcinogen-induced DNA dam