There is a compound called proanthocyanldins which is a type of polyphenol and it contains many antioxidant properties. This compound is the reason the free radical scavenging properties exist in the grape seeds.
Gallic acid decreased cell viability in a dose-dependent manner in both DU145 and 22Rv1 cells largely via apoptosis induction.
Taken together, our findings show the anti-PCa efficacy of gallic acid and provide a rationale for additional studies with this naturally-occurring agent for its efficacy against PCa.
We investigated the in vivo efficacy of grape seed extract (GSE, patented as Traconol) against prostate cancer (PCA) and associated molecular events.
Collectively, present findings provide in vivo evidence for antiproliferative, apoptotic and antiangiogenic effects of GSE, and their correlation with inhibition of advanced human prostate tumor xenograft growth in athymic nude mice.
Anti-Cancer - In this study they investigated the anti-cancer effects of grape seed extract (GSE) and doxorubicin (Dox), either alone or in combination, in estrogen receptor-positive MCF-7 and receptor-negative MDA-MB468 human breast carcinoma cells.
In quantitative apoptosis studies, GSE and Dox alone and in combination showed comparable apoptotic death of MCF-7 cells, however, a combination of the two was inhibitory to Dox induced apoptosis in MDA-MB468 cells.
Together, these results suggest a strong possibility of synergistic efficacy of GSE and Dox combination for breast cancer treatment, independent of estrogen receptor status of the cancer cell.
In this next study they investigated the in vitro and in vivo anticancer effects and associated mechanisms of grape seed extract (GSE), a rich source of proanthocyanidins, against colorectal cancer.
GSE may be an effective chemopreventive agent against colorectal cancer, and that growth inhibitory and apoptotic effects of G