The percentage of both objective tumor regressions and disease control was significantly higher in patients concomitantly treated with Aloe than with chemotherapy alone, as well as the percent of 3-year survival patients.
This study seems to suggest that Aloe may be successfully associated with chemotherapy to increase its efficacy in terms of both tumor regression rate and survival time.
The goal of this study is to investigate the effects and molecular mechanisms of emodin and aloe-emodin on breast cancer cell proliferation. Our results indicate that both emodin and aloe-emodin are capable of inhibiting breast cancer cell proliferation by downregulating ERα protein levels, thereby suppressing ERα transcriptional activation.
In this study they provided evidence showing that the anticancer mechanisms of the anthraquinone derivatives emodin and aloe-emodin are mediated via an ERα-dependent pathway in breast cancer cells.
Acid Reflux Healing Plant - Herbal medicines offer many potential ways to help people with gastroesophageal reflux disease (GERD), including by treating the underlying transient lower esophageal sphincter relaxations (TLESR), helping relieve symptoms, and reducing inflammation.
Aloe leaf gel can reduce acute symptoms and heal acid-damaged tissues.
The antigastric effects of Aloe arborescens Miller var. natalensis Berger extract with high molecular weight components ((A) MW over 5000 and (B) MW over 50 000)) were examined by changes of ulcer index with three different experimental models in rats. The suppressive effects were evaluated under (1) stress (immobilization in water) and (2) ligation of pylorus, and the healing effects were likewise examined with the (3) acetic acid test.
These results suggest the existence of both suppressive and healing substances on gastric ulcer in the Aloe extract within the range of MW 5000–50 000. These effects were confirmed by micro‐ and macroscopic findings.
The results suggest the potential of aloe juice for use as an antidiabetic agent.
Anti-Inflammatory - Clinical evaluations have revealed that the pharmacological active ingredients are concentrated in both the gel and rind of the aloe leaves. Bioactive compounds from aloe are very effective in various treatments, such as burns, allergic reactions, rheumatoid arthritis, rheumatic fever, acid indigestion, ulcers, diabetes, skin diseases, dysentery, diarrhea, piles and inflammatory conditions of the digestive system and other internal organs, including the stomach, small intestine, liver, kidney, and pancreas.
The active ingredients have been shown to have analgesic, anti-inflammatory, antioxidant and anticancer activity. The present review is therefore, an effort to give a detailed survey of the literature on its traditional, phytochemical and pharmacological properties.
Wound Healing - Two types of the whole-leaf juice prepared from either Aloe ferox Miller or Aloe arborescens Miller were used in this study. Incision wound healing was investigated using both the rat and rabbit model. The wound closure rate with and without the topical administration of the whole-leaf juice were monitored.
Results indicated that the two types of whole-leaf juice preparations exhibit the therapeutic properties, including facilitation of the healing process, selective inhibition of the microbial growth and zero side-effect on the skin, during the observation period. It is concluded that both of Aloe whole-leaf juice preparations have the positive potential for skin medicinal application.
Alzheimer Medicine - Besides, it is well known to have beneficial phytotherapeutic, anticancer, and radio-protective properties. In this study, we first provided evidence that A. arborescens extract protects IMR32, a neuroblastoma human cellular line, from toxicity induced by beta amyloid, the peptide responsible for Alzheimer's disease.
Based on these preliminary observations we suggest that use ofA. arborescens extract could be developed as agents for the management of AD.