The data presently available suggest that OLE could provide a protective and therapeutic effect against a number of pathologies, including AD as well as obesity, type 2 diabetes, non-alcoholic hepatitis, and other natural or experimentally-induced pathological conditions.
In particular, the recent data on the cellular and molecular correlates of OLE neuroprotection suggest it could also play a therapeutic role against AD.
Oxidative Stress - This study aimed to evaluate the significance of supplementation of oleuropein in reducing oxidative stress and hyperglycemia in alloxan-induced diabetic rabbits.
After induction of diabetes, a significant rise in plasma and erythrocyte malondialdehyde (MDA) and blood glucose as well as alteration in enzymatic and non-enzymatic antioxidants was observed in all diabetic animals.
These results demonstrate that oleuropein may be of advantage in inhibiting hyperglycemia and oxidative stress induced by diabetes and suggest that administration of oleuropein may be helpful in the prevention of diabetic complications associated with oxidative stress.
Antioxidant - The main reaction products obtainable by the hydrolysis of commercially available oleuropein by hyperthermophilic β-glycosidase were purified and structurally characterized by UV and 1H and 13C NMR analyses.
Their antioxidant activity, in particular their capacity to inhibit the fatty acid peroxidation rate, was studied. This molecule, under the reaction conditions (pH 7.0, 60 °C) required for β-glycosidase activity, rapidly gives rise to phenylethanol.
Antimicrobial - Oleuropein, t